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Conserved domains on  [gi|569006219|ref|XP_006526653|]
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KN motif and ankyrin repeat domain-containing protein 1 isoform X6 [Mus musculus]

Protein Classification

KN_motif domain-containing protein( domain architecture ID 10572546)

KN_motif domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KN_motif pfam12075
KN motif; This small motif is found at the N-terminus of Kank proteins and has been called the ...
 58-96 5.60e-18

KN motif; This small motif is found at the N-terminus of Kank proteins and has been called the KN (for Kank N-terminal) motif. This protein is found in eukaryotes. Proteins in this family are typically between 413 to 1202 amino acids in length. This protein is found associated with pfam00023. This protein has two conserved sequence motifs: TPYG and LDLDF. Kank1 was obtained by positional cloning of a tumor suppressor gene in renal cell carcinoma, while the other members were found by homology search. The family is involved in the regulation of actin polymerization and cell motility through signaling pathways containing PI3K/Akt and/or unidentified modulators/effectors.


:

Pssm-ID: 432311  Cd Length: 39  Bit Score: 78.16  E-value: 5.60e-18
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 569006219    58 PYFVETPYGFQLDLDFVKYVDDIQKGNTIKKLNIQKRRK 96
Cdd:pfam12075    1 PYSVETPYGFHLDLDFLKYVEDIESGQTIRRARVQRRPR 39
YhaN super family cl34808
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
297-528 2.51e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


The actual alignment was detected with superfamily member COG4717:

Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 41.68  E-value: 2.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006219  297 IALKRLKELEEQVRTIPVLQVKISVLQEEKRQLASQLKSQRASSQNEACGVRKRSYSAGNASQLELLARARRgggELyid 376
Cdd:COG4717    68 LNLKELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQLLPLYQELEALEA---EL--- 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006219  377 yeEEEMESVEQSTQRIQEFRQLTADMQALERKIQDSSCEVASELRENGQcpsrecksvavgsdenmndvvVYHRDLRPCK 456
Cdd:COG4717   142 --AELPERLEELEERLEELRELEEELEELEAELAELQEELEELLEQLSL---------------------ATEEELQDLA 198

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 569006219  457 DTavgtvtetrnvgisvteamlgvITEADKEIELQQQTIEALKEKIYRLEVQLKETTHDREMTKLKQELQAA 528
Cdd:COG4717   199 EE----------------------LEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERLKEA 248
 
Name Accession Description Interval E-value
KN_motif pfam12075
KN motif; This small motif is found at the N-terminus of Kank proteins and has been called the ...
 58-96 5.60e-18

KN motif; This small motif is found at the N-terminus of Kank proteins and has been called the KN (for Kank N-terminal) motif. This protein is found in eukaryotes. Proteins in this family are typically between 413 to 1202 amino acids in length. This protein is found associated with pfam00023. This protein has two conserved sequence motifs: TPYG and LDLDF. Kank1 was obtained by positional cloning of a tumor suppressor gene in renal cell carcinoma, while the other members were found by homology search. The family is involved in the regulation of actin polymerization and cell motility through signaling pathways containing PI3K/Akt and/or unidentified modulators/effectors.


Pssm-ID: 432311  Cd Length: 39  Bit Score: 78.16  E-value: 5.60e-18
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 569006219    58 PYFVETPYGFQLDLDFVKYVDDIQKGNTIKKLNIQKRRK 96
Cdd:pfam12075    1 PYSVETPYGFHLDLDFLKYVEDIESGQTIRRARVQRRPR 39
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
297-528 2.51e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 41.68  E-value: 2.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006219  297 IALKRLKELEEQVRTIPVLQVKISVLQEEKRQLASQLKSQRASSQNEACGVRKRSYSAGNASQLELLARARRgggELyid 376
Cdd:COG4717    68 LNLKELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQLLPLYQELEALEA---EL--- 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006219  377 yeEEEMESVEQSTQRIQEFRQLTADMQALERKIQDSSCEVASELRENGQcpsrecksvavgsdenmndvvVYHRDLRPCK 456
Cdd:COG4717   142 --AELPERLEELEERLEELRELEEELEELEAELAELQEELEELLEQLSL---------------------ATEEELQDLA 198

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 569006219  457 DTavgtvtetrnvgisvteamlgvITEADKEIELQQQTIEALKEKIYRLEVQLKETTHDREMTKLKQELQAA 528
Cdd:COG4717   199 EE----------------------LEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERLKEA 248
 
Name Accession Description Interval E-value
KN_motif pfam12075
KN motif; This small motif is found at the N-terminus of Kank proteins and has been called the ...
 58-96 5.60e-18

KN motif; This small motif is found at the N-terminus of Kank proteins and has been called the KN (for Kank N-terminal) motif. This protein is found in eukaryotes. Proteins in this family are typically between 413 to 1202 amino acids in length. This protein is found associated with pfam00023. This protein has two conserved sequence motifs: TPYG and LDLDF. Kank1 was obtained by positional cloning of a tumor suppressor gene in renal cell carcinoma, while the other members were found by homology search. The family is involved in the regulation of actin polymerization and cell motility through signaling pathways containing PI3K/Akt and/or unidentified modulators/effectors.


Pssm-ID: 432311  Cd Length: 39  Bit Score: 78.16  E-value: 5.60e-18
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 569006219    58 PYFVETPYGFQLDLDFVKYVDDIQKGNTIKKLNIQKRRK 96
Cdd:pfam12075    1 PYSVETPYGFHLDLDFLKYVEDIESGQTIRRARVQRRPR 39
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
297-528 2.51e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 41.68  E-value: 2.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006219  297 IALKRLKELEEQVRTIPVLQVKISVLQEEKRQLASQLKSQRASSQNEACGVRKRSYSAGNASQLELLARARRgggELyid 376
Cdd:COG4717    68 LNLKELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQLLPLYQELEALEA---EL--- 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006219  377 yeEEEMESVEQSTQRIQEFRQLTADMQALERKIQDSSCEVASELRENGQcpsrecksvavgsdenmndvvVYHRDLRPCK 456
Cdd:COG4717   142 --AELPERLEELEERLEELRELEEELEELEAELAELQEELEELLEQLSL---------------------ATEEELQDLA 198

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 569006219  457 DTavgtvtetrnvgisvteamlgvITEADKEIELQQQTIEALKEKIYRLEVQLKETTHDREMTKLKQELQAA 528
Cdd:COG4717   199 EE----------------------LEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERLKEA 248
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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