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Conserved domains on  [gi|569006146|ref|XP_006526617|]
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WD repeat-containing protein 74 isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
 1-194 5.93e-96

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


:

Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 283.73  E-value: 5.93e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006146   1 MRQDPtHTHVVATCGKENALKVWDLQGSEEPVFRAKNVRNDWLDLRVPIWDQDTQFLPGSQ--KLVTCTGYHQVRVYDPv 78
Cdd:cd22857  132 MRVDP-NENYFAFGGKEVELNVWDLEEKPGKIWRAKNVPNDSLGLRVPVWVTDLTFLSKDDhrKIVTGTGYHQVRLYDT- 209

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006146  79 SPQRRPVLEATYGEYPLTAMTLTPEGNSVIVGNTHGQLAEIDFRQGRLLGCLKGLAG-SVRGLQCHPSKPLLASCGLDRV 157
Cdd:cd22857  210 RAQRRPVVSVDFGETPIKAVAEDPDGHTVYVGDTSGDLASIDLRTGKLLGCFKGKCGgSIRSIARHPELPLIASCGLDRY 289

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 569006146 158 LRIHRIRNPRgLEHKVYLKSQLNCLLLSGRDNWEDEP 194
Cdd:cd22857  290 LRIWDTETRQ-LLSKVYLKQRLTAVVFDSSFSPEEEA 325
 
Name Accession Description Interval E-value
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
 1-194 5.93e-96

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 283.73  E-value: 5.93e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006146   1 MRQDPtHTHVVATCGKENALKVWDLQGSEEPVFRAKNVRNDWLDLRVPIWDQDTQFLPGSQ--KLVTCTGYHQVRVYDPv 78
Cdd:cd22857  132 MRVDP-NENYFAFGGKEVELNVWDLEEKPGKIWRAKNVPNDSLGLRVPVWVTDLTFLSKDDhrKIVTGTGYHQVRLYDT- 209

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006146  79 SPQRRPVLEATYGEYPLTAMTLTPEGNSVIVGNTHGQLAEIDFRQGRLLGCLKGLAG-SVRGLQCHPSKPLLASCGLDRV 157
Cdd:cd22857  210 RAQRRPVVSVDFGETPIKAVAEDPDGHTVYVGDTSGDLASIDLRTGKLLGCFKGKCGgSIRSIARHPELPLIASCGLDRY 289

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 569006146 158 LRIHRIRNPRgLEHKVYLKSQLNCLLLSGRDNWEDEP 194
Cdd:cd22857  290 LRIWDTETRQ-LLSKVYLKQRLTAVVFDSSFSPEEEA 325
WD40 COG2319
WD40 repeat [General function prediction only];
9-169 7.41e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 64.16  E-value: 7.41e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006146   9 HVVATCGKENALKVWDLQGSEEPvfRAKNVRNDWldlrvpIWDQDtqFLPGSQKLVTCTGYHQVRVYDPVSPQRRPVLEA 88
Cdd:COG2319  217 KLLASGSADGTVRLWDLATGKLL--RTLTGHSGS------VRSVA--FSPDGRLLASGSADGTVRLWDLATGELLRTLTG 286

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006146  89 TYGeyPLTAMTLTPEGNSVIVGNTHGQLAEIDFRQGRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIHRIRNPRG 168
Cdd:COG2319  287 HSG--GVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGEL 364


                 .
gi 569006146 169 L 169
Cdd:COG2319  365 L 365
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 123-161 1.00e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.14  E-value: 1.00e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 569006146   123 QGRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIH 161
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
124-160 7.06e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 33.47  E-value: 7.06e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 569006146  124 GRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRI 160
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKV 37
 
Name Accession Description Interval E-value
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
 1-194 5.93e-96

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 283.73  E-value: 5.93e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006146   1 MRQDPtHTHVVATCGKENALKVWDLQGSEEPVFRAKNVRNDWLDLRVPIWDQDTQFLPGSQ--KLVTCTGYHQVRVYDPv 78
Cdd:cd22857  132 MRVDP-NENYFAFGGKEVELNVWDLEEKPGKIWRAKNVPNDSLGLRVPVWVTDLTFLSKDDhrKIVTGTGYHQVRLYDT- 209

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006146  79 SPQRRPVLEATYGEYPLTAMTLTPEGNSVIVGNTHGQLAEIDFRQGRLLGCLKGLAG-SVRGLQCHPSKPLLASCGLDRV 157
Cdd:cd22857  210 RAQRRPVVSVDFGETPIKAVAEDPDGHTVYVGDTSGDLASIDLRTGKLLGCFKGKCGgSIRSIARHPELPLIASCGLDRY 289

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 569006146 158 LRIHRIRNPRgLEHKVYLKSQLNCLLLSGRDNWEDEP 194
Cdd:cd22857  290 LRIWDTETRQ-LLSKVYLKQRLTAVVFDSSFSPEEEA 325
Nsa1_WDR74-like cd22850
Ribosome biogenesis protein Nsa1 and similar proteins; Ribosome biogenesis protein Nsa1 ...
 1-188 3.50e-73

Ribosome biogenesis protein Nsa1 and similar proteins; Ribosome biogenesis protein Nsa1 (Nop7-associated 1) from fungi and WDR74 (WD repeat-containing protein 74) from mammals and plants, are homologous essential factors for ribosome assembly. In cooperation with the assembly factor Rix7/NVL2, Nsa1/WDR74 participates in an early cleavage of the pre-rRNA processing pathway. Rix7/NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of Nsa1/WDR74 from nucleolar pre-60S particles. Nsa1/WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase Rix7/NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439302 [Multi-domain]  Cd Length: 333  Bit Score: 225.97  E-value: 3.50e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006146   1 MRQDPTHTHVVATCGKENALKVWDL---QGSEEPVFRAKNVRNDWLDLRVPIWDQDTQFLPGS----QKLVTCTGYHQVR 73
Cdd:cd22850  139 FRVNPTDEGVFAYGGKENDLKLWDLekdFLKLKQIWKAKNVKNDRLDLRVPVWITAITFLPPDdhrkFKFVTGTRYGQVR 218

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006146  74 VYDPVSpQRRPVleatYGEYPLTAMTLTPEGNSVIVGNTHGQLAEIDFRQGRLLGCLKGLAG-SVRGLQCHPS--KPLLA 150
Cdd:cd22850  219 LYDTSA-GRRPV----FSEKPIKKPEEDLDGHTVYVGDTSGDLALIDIRTGKLLGRLLGKYGgSITGAVRHPElfDPYLA 293

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 569006146 151 SCGLDRVLRIHRIRNPRgLEHKVYLKSQ-LNCLLLSGRD 188
Cdd:cd22850  294 SGGLDRYLRVFDIETRE-LLAKVYLGKQiLTVVVLDDEE 331
Nsa1 cd22858
Ribosome Biogenesis Protein Nsa1; Ribosome biogenesis protein Nsa1 (Nop7-associated 1) from ...
 4-224 2.92e-38

Ribosome Biogenesis Protein Nsa1; Ribosome biogenesis protein Nsa1 (Nop7-associated 1) from fungi is an essential factor for ribosome assembly. In cooperation with the assembly factor Rix7, Nsa1 participates in an early cleavage of the pre-rRNA processing pathway. Rix7 is a type II double ring, AAA-ATPase, that may mediate the release of Nsa1 from nucleolar pre-60S particles. The release of Nsa1 from a discrete preribosomal particle may trigger the progression of 60S ribosome biogenesis. Nsa1 is essential for cell viability in yeast. It contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase Rix7, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439304  Cd Length: 399  Bit Score: 137.35  E-value: 2.92e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006146   4 DPTHTHVVATCGKENALKVWDLQGSEEP------VFRAKNVRNDWLDLRVPIWDQDTQFLPGSQ------KLVTCTGYHQ 71
Cdd:cd22858  155 NPTDPGVFAYGGKENDLKIVELFSDKKKffklkqIWEAKNVKNDRLDLRVPIWITGILFLKPSPskgfdyKFITVTRYGH 234

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006146  72 VRVYDpVSPQRRPVLEATYGEYPLTAMTLTpegnSVIVGNTHGQLAE-----IDFR--------QGRLLGCLKG--LAGS 136
Cdd:cd22858  235 LRKYD-TTHGRKPIKSYKLLPKPELTEPLT----ELIISDTHSLIAKlslitTDSKksvsagdgKGRLLGKYGGgdITGA 309

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006146 137 VRGLQCHPSKpLLASCGLDRVLRIHRIRNpRGLEHKVYLKSQLN-CLLLSGRDnwEDEPQEPQEPNQ---VPSEDTETD- 211
Cdd:cd22858  310 VSAVDVFEDK-YLATGGLDRYLRVFDLET-RELLAKVYVGSKISsVLLLDDED--IELPESEKKKKKkkkRKEEEEEEDd 385

                        250
                 ....*....|....
gi 569006146 212 -ELWASLEAAAKRK 224
Cdd:cd22858  386 eELWNELEEKKKKR 399
WD40 COG2319
WD40 repeat [General function prediction only];
9-169 7.41e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 64.16  E-value: 7.41e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006146   9 HVVATCGKENALKVWDLQGSEEPvfRAKNVRNDWldlrvpIWDQDtqFLPGSQKLVTCTGYHQVRVYDPVSPQRRPVLEA 88
Cdd:COG2319  217 KLLASGSADGTVRLWDLATGKLL--RTLTGHSGS------VRSVA--FSPDGRLLASGSADGTVRLWDLATGELLRTLTG 286

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006146  89 TYGeyPLTAMTLTPEGNSVIVGNTHGQLAEIDFRQGRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIHRIRNPRG 168
Cdd:COG2319  287 HSG--GVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGEL 364


                 .
gi 569006146 169 L 169
Cdd:COG2319  365 L 365
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 7-167 2.89e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 61.97  E-value: 2.89e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006146   7 HTHVVATCGKENALKVWDL-QGSEEPVFRAKNvrnDW-LDLRvpiWDQDTQFLpgsqklVTCTGYHQVRVYDPVSPQRRP 84
Cdd:cd00200  104 DGRILSSSSRDKTIKVWDVeTGKCLTTLRGHT---DWvNSVA---FSPDGTFV------ASSSQDGTIKLWDLRTGKCVA 171

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006146  85 VLEATYGeyPLTAMTLTPEGNSVIVGNTHGQLAEIDFRQGRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIHRIR 164
Cdd:cd00200  172 TLTGHTG--EVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLR 249


                 ...
gi 569006146 165 NPR 167
Cdd:cd00200  250 TGE 252
WD40 COG2319
WD40 repeat [General function prediction only];
11-165 4.59e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 59.15  E-value: 4.59e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006146  11 VATCGKENALKVWDLQGSEEPVFRAKNVRndwldlrvPIWDqdTQFLPGSQKLVTCTGYHQVRVYDPVSPQRRPVLEAty 90
Cdd:COG2319  261 LASGSADGTVRLWDLATGELLRTLTGHSG--------GVNS--VAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTG-- 328

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 569006146  91 GEYPLTAMTLTPEGNSVIVGNTHGQLAEIDFRQGRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIHRIRN 165
Cdd:COG2319  329 HTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
9-167 2.01e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 57.23  E-value: 2.01e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006146   9 HVVATCGKENALKVWDLQGSEEPVFRAKNVRndwldlrvPIWDqdTQFLPGSQKLVTCTGYHQVRVYDPVSPQRRPVLEA 88
Cdd:COG2319   91 RLLASASADGTVRLWDLATGLLLRTLTGHTG--------AVRS--VAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG 160

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 569006146  89 tyGEYPLTAMTLTPEGNSVIVGNTHGQLAEIDFRQGRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIHRIRNPR 167
Cdd:COG2319  161 --HSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGK 237
WD40 COG2319
WD40 repeat [General function prediction only];
11-167 5.31e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 55.69  E-value: 5.31e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006146  11 VATCGKENALKVWDLQ-GSEEPVFRAknvRNDWLDlrvpiwdqDTQFLPGSQKLVTCTGYHQVRVYDPVSPQRRPVLEAt 89
Cdd:COG2319  135 LASGSADGTVRLWDLAtGKLLRTLTG---HSGAVT--------SVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTG- 202

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 569006146  90 yGEYPLTAMTLTPEGNSVIVGNTHGQLAEIDFRQGRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIHRIRNPR 167
Cdd:COG2319  203 -HTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGE 279
WD40 COG2319
WD40 repeat [General function prediction only];
56-167 1.78e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 51.45  E-value: 1.78e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006146  56 FLPGSQKLVTCTGYHQVRVYDPVSPQRRPVLEATYGeyPLTAMTLTPEGNSVIVGNTHGQLAEIDFRQGRLLGCLKGLAG 135
Cdd:COG2319   86 FSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTG--AVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSG 163

                         90       100       110
                 ....*....|....*....|....*....|..
gi 569006146 136 SVRGLQCHPSKPLLASCGLDRVLRIHRIRNPR 167
Cdd:COG2319  164 AVTSVAFSPDGKLLASGSDDGTVRLWDLATGK 195
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 7-189 2.09e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 50.80  E-value: 2.09e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006146   7 HTHVVATCGKENALKVWDLQGSEEPvfraknvrndwLDLRVPI-WDQDTQFLPGSQKLVTCTGYHQVRVYDPVSPQRRpv 85
Cdd:cd00200   20 DGKLLATGSGDGTIKVWDLETGELL-----------RTLKGHTgPVRDVAASADGTYLASGSSDKTIRLWDLETGECV-- 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006146  86 leATYG--EYPLTAMTLTPEGNSVIVGNTHGQLAEIDFRQGRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIHRI 163
Cdd:cd00200   87 --RTLTghTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDL 164

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 569006146 164 RNPRGLE----HKVYLKS-----QLNCLLLSGRDN 189
Cdd:cd00200  165 RTGKCVAtltgHTGEVNSvafspDGEKLLSSSSDG 199
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 7-190 1.61e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 48.10  E-value: 1.61e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006146   7 HTHVVATCGKENALKVWDLQgSEEPVFRAKNVRNDWLDLRvpiwdqdtqFLPGSQKLVTCTGYHQVRVYDPVSPQRRPVL 86
Cdd:cd00200   62 DGTYLASGSSDKTIRLWDLE-TGECVRTLTGHTSYVSSVA---------FSPDGRILSSSSRDKTIKVWDVETGKCLTTL 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006146  87 EATygEYPLTAMTLTPEGNSVIVGNTHGQLAEIDFRQGRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIHRIRNP 166
Cdd:cd00200  132 RGH--TDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTG 209

                        170       180
                 ....*....|....*....|....*.
gi 569006146 167 RglEHKVYL--KSQLNCLLLSGRDNW 190
Cdd:cd00200  210 K--CLGTLRghENGVNSVAFSPDGYL 233
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 94-167 5.29e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 46.56  E-value: 5.29e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 569006146  94 PLTAMTLTPEGNSVIVGNTHGQLAEIDFRQGRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIHRIRNPR 167
Cdd:cd00200   11 GVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGE 84
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 55-167 2.52e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 41.55  E-value: 2.52e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569006146  55 QFLPGSQKLVTCTGYHQVRVYDPVSPQRRPVLEATYGeyPLTAMTLTPEGNSVIVGNTHGQLAEIDFRQGRLLGCLKGLA 134
Cdd:cd00200   16 AFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTG--PVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHT 93

                         90       100       110
                 ....*....|....*....|....*....|...
gi 569006146 135 GSVRGLQCHPSKPLLASCGLDRVLRIHRIRNPR 167
Cdd:cd00200   94 SYVSSVAFSPDGRILSSSSRDKTIKVWDVETGK 126
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 123-161 1.00e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.14  E-value: 1.00e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 569006146   123 QGRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIH 161
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
124-160 7.06e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 33.47  E-value: 7.06e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 569006146  124 GRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRI 160
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKV 37
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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