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Conserved domains on  [gi|569003631|ref|XP_006525886|]
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kelch-like protein 14 isoform X1 [Mus musculus]

Protein Classification

kelch-like protein 14( domain architecture ID 13033046)

kelch-like protein 14 (KLHL14) is a novel torsinA-interacting protein implicated in dystonia pathogenesis

Gene Symbol:  KLHL14
Gene Ontology:  GO:0005515
PubMed:  23676014|15544948|17120193

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BTB_POZ_KLHL14_printor cd18243
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1-190 1.03e-70

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14); KLHL14 is also called protein interactor of Torsin-1A (TOR1A), protein interactor of torsinA, or Printor. It is a novel torsinA-interacting protein that preferentially interacts with ATP-free form of TOR1A and is implicated in dystonia pathogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


:

Pssm-ID: 349552 [Multi-domain]  Cd Length: 130  Bit Score: 224.53  E-value: 1.03e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631   1 MSRSGDRTSTFDPSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSshpplgggvggqdglga 80
Cdd:cd18243    1 MSRSGDRTSTFDPSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFS----------------- 63

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  81 pkdqqqqqqpqqqppqqqqpppqeepgtpssspddklltspraINNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVL 160
Cdd:cd18243   64 -------------------------------------------INNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVL 100

                        170       180       190
                 ....*....|....*....|....*....|
gi 569003631 161 SVSKILHIPQVTKLCVQFLNDQISVQNYKQ 190
Cdd:cd18243  101 SVSKILHIPQVTKLCVQFLNDQISVQNYKQ 130
BACK_KLHL14 cd18453
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 14 (KLHL14); KLHL14, also ...
 183-284 5.63e-69

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 14 (KLHL14); KLHL14, also termed protein interactor of Torsin-1A, or Printor, or protein interactor of torsinA, is a novel ATP-free form of torsinA-interacting protein implicated in dystonia pathogenesis.


:

Pssm-ID: 350528  Cd Length: 102  Bit Score: 219.12  E-value: 5.63e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 183 ISVQNYKQVCKIAALHGLEETKKLANKYLVEDVLLLNFEEMRALLDSLPPPVESELALFQMSVLWLEHDRETRMQYAPDL 262
Cdd:cd18453    1 ISVQNYKQVCKIAALHGLEETKKLANKYLVEDVLLLNFEEMRAMLDSLPPPVESELALFQMSVLWLEHDRETRMQYAPDL 80

                         90       100
                 ....*....|....*....|..
gi 569003631 263 MKRLRFALIPAPELVERVQSVD 284
Cdd:cd18453   81 MKRLRFALIPAPELVERVQSVD 102
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
326-579 1.42e-47

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 168.41  E-value: 1.42e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 326 LLLVGGLPPGpdrLPSNLVQYYDDEKKTWKILTIMPYNSAHH-CVVEVENFLFVLGGEDQWNPNGKHSTNfVSRYDPRFN 404
Cdd:COG3055   25 VYVAGGLSGG---SASNSFEVYDPATNTWSELAPLPGPPRHHaAAVAQDGKLYVFGGFTGANPSSTPLND-VYVYDPATN 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 405 SWIQLPPMQERRASFYACRLDKHLYVIGGRNETGYLSSVECYNLDTNEWRYVSSLPQPLAAHAGAVH-NGKIYISGGVHN 483
Cdd:COG3055  101 TWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDHLAAAVLpDGKILVIGGRNG 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 484 GEYVpwlycydpvmDVWARKQDMNTKRAIHTLAVMNDRLYAIGGNHlkGFSHLdvmlVECYDPKGDQWNILqTPILEGRS 563
Cdd:COG3055  181 SGFS----------NTWTTLAPLPTARAGHAAAVLGGKILVFGGES--GFSDE----VEAYDPATNTWTAL-GELPTPRH 243

                        250
                 ....*....|....*.
gi 569003631 564 GPGCAVLDDSIYLVGG 579
Cdd:COG3055  244 GHAAVLTDGKVYVIGG 259
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 562-604 1.80e-05

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


:

Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 42.21  E-value: 1.80e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 569003631  562 RSGPGCAVLDDSIYLVGGysWSMGAYKSSTICYCPEKGTWTEL 604
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGG--FDGNQSLNSVEVYDPETNTWSKL 42
 
Name Accession Description Interval E-value
BTB_POZ_KLHL14_printor cd18243
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1-190 1.03e-70

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14); KLHL14 is also called protein interactor of Torsin-1A (TOR1A), protein interactor of torsinA, or Printor. It is a novel torsinA-interacting protein that preferentially interacts with ATP-free form of TOR1A and is implicated in dystonia pathogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349552 [Multi-domain]  Cd Length: 130  Bit Score: 224.53  E-value: 1.03e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631   1 MSRSGDRTSTFDPSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSshpplgggvggqdglga 80
Cdd:cd18243    1 MSRSGDRTSTFDPSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFS----------------- 63

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  81 pkdqqqqqqpqqqppqqqqpppqeepgtpssspddklltspraINNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVL 160
Cdd:cd18243   64 -------------------------------------------INNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVL 100

                        170       180       190
                 ....*....|....*....|....*....|
gi 569003631 161 SVSKILHIPQVTKLCVQFLNDQISVQNYKQ 190
Cdd:cd18243  101 SVSKILHIPQVTKLCVQFLNDQISVQNYKQ 130
BACK_KLHL14 cd18453
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 14 (KLHL14); KLHL14, also ...
 183-284 5.63e-69

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 14 (KLHL14); KLHL14, also termed protein interactor of Torsin-1A, or Printor, or protein interactor of torsinA, is a novel ATP-free form of torsinA-interacting protein implicated in dystonia pathogenesis.


Pssm-ID: 350528  Cd Length: 102  Bit Score: 219.12  E-value: 5.63e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 183 ISVQNYKQVCKIAALHGLEETKKLANKYLVEDVLLLNFEEMRALLDSLPPPVESELALFQMSVLWLEHDRETRMQYAPDL 262
Cdd:cd18453    1 ISVQNYKQVCKIAALHGLEETKKLANKYLVEDVLLLNFEEMRAMLDSLPPPVESELALFQMSVLWLEHDRETRMQYAPDL 80

                         90       100
                 ....*....|....*....|..
gi 569003631 263 MKRLRFALIPAPELVERVQSVD 284
Cdd:cd18453   81 MKRLRFALIPAPELVERVQSVD 102
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
326-579 1.42e-47

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 168.41  E-value: 1.42e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 326 LLLVGGLPPGpdrLPSNLVQYYDDEKKTWKILTIMPYNSAHH-CVVEVENFLFVLGGEDQWNPNGKHSTNfVSRYDPRFN 404
Cdd:COG3055   25 VYVAGGLSGG---SASNSFEVYDPATNTWSELAPLPGPPRHHaAAVAQDGKLYVFGGFTGANPSSTPLND-VYVYDPATN 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 405 SWIQLPPMQERRASFYACRLDKHLYVIGGRNETGYLSSVECYNLDTNEWRYVSSLPQPLAAHAGAVH-NGKIYISGGVHN 483
Cdd:COG3055  101 TWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDHLAAAVLpDGKILVIGGRNG 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 484 GEYVpwlycydpvmDVWARKQDMNTKRAIHTLAVMNDRLYAIGGNHlkGFSHLdvmlVECYDPKGDQWNILqTPILEGRS 563
Cdd:COG3055  181 SGFS----------NTWTTLAPLPTARAGHAAAVLGGKILVFGGES--GFSDE----VEAYDPATNTWTAL-GELPTPRH 243

                        250
                 ....*....|....*.
gi 569003631 564 GPGCAVLDDSIYLVGG 579
Cdd:COG3055  244 GHAAVLTDGKVYVIGG 259
PHA03098 PHA03098
kelch-like protein; Provisional
 140-602 3.32e-44

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 165.71  E-value: 3.32e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 140 VLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQNYKQVCKIAALHGLeetKKLANK---------- 209
Cdd:PHA03098  62 VIKYIYTGKINITSNNVKDILSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGC---KKLYSAaynyirnnie 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 210 --YLVEDVLLLNFEEMRALLDSLPPPVESELALFQMSVLWLEHDRETRMQYAPDLMKRLRFALIpAPELVERVqsvdfmr 287
Cdd:PHA03098 139 liYNDPDFIYLSKNELIKILSDDKLNVSSEDVVLEIIIKWLTSKKNNKYKDICLILKVLRITFL-SEEGIKKL------- 210

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 288 tdpvcqKLLLDAMNYHLMPFRQHCRQSLASRIRSNKKMLLLVGGLP------PGPDRLPSNLVQYYDDEKKTWKILTImP 361
Cdd:PHA03098 211 ------KRWKLRIKKKKIVFNKRCIKIIYSKKYNLNKILPRSSTFGsiiyihITMSIFTYNYITNYSPLSEINTIIDI-H 283

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 362 YNSAHHCVVEvENFLFVLGGEDQWNpngkHSTNFVSRYDPRFNSWIQLPPMQERRASFYACRLDKHLYVIGGRNETGYLS 441
Cdd:PHA03098 284 YVYCFGSVVL-NNVIYFIGGMNKNN----LSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISLN 358

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 442 SVECYNLDTNEWRYVSSLPQPLAAHAGAVHNGKIYISGGVH-NGEYVPWLYCYDPVMDVWARKQDMNTKRAIHTLAVMND 520
Cdd:PHA03098 359 TVESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGGISkNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDG 438

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 521 RLYAIGgnhlkGFSHLDVML----VECYDPKGDQWNILqTPILEGRSGPGCAVLDDSIYLVGGYswsMGAYKSSTI-CYC 595
Cdd:PHA03098 439 KIYVIG-----GISYIDNIKvyniVESYNPVTNKWTEL-SSLNFPRINASLCIFNNKIYVVGGD---KYEYYINEIeVYD 509


                 ....*..
gi 569003631 596 PEKGTWT 602
Cdd:PHA03098 510 DKTNTWT 516
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 23-183 1.82e-20

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 86.93  E-value: 1.82e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631   23 LNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHPplgggvggqdglgapkdqqqqqqpqqqppqqqqppp 102
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQE------------------------------------ 44

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  103 qeepgtpssspddklltSPRAINNLVLQGCSSIGLRLVLEYLYTANvTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQ 182
Cdd:pfam00651  45 -----------------SESSVSEITLDDVSPEDFEALLEFMYTGK-LISEENVDDLLAAADKLQIPSLVDKCEEFLIKS 106


                  .
gi 569003631  183 I 183
Cdd:pfam00651 107 L 107
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 191-279 5.75e-14

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 68.14  E-value: 5.75e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631   191 VCKIAALHGLEETKKLANKYLV---------EDVLLLNFEEMRALL--DSLPppVESELALFQMSVLWLEHDRETRMQYA 259
Cdd:smart00875   4 IRRFADAHGLEELAEKALRFILqnfsevsssEEFLELPLEQLLELLssDDLN--VSSEEEVFEAVLRWVKHDPEKRREHL 81

                           90       100
                   ....*....|....*....|
gi 569003631   260 PDLMKRLRFALIPAPELVER 279
Cdd:smart00875  82 PELLEHVRLPLLSPDYLLEV 101
Kelch smart00612
Kelch domain;
427-473 2.82e-13

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 64.12  E-value: 2.82e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 569003631   427 HLYVIGGRNETGYLSSVECYNLDTNEWRYVSSLPQPLAAHAGAVHNG 473
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 34-183 4.13e-13

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 65.40  E-value: 4.13e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631    34 DVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHPplgggvggqdglgapkdqqqqqqpqqqppqqqqpppqeepgtpssSP 113
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDF---------------------------------------------KE 35

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631   114 DDKlltspraiNNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQI 183
Cdd:smart00225  36 SDK--------SEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYLQIPGLVELCEEFLLKLL 97
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 194-281 5.05e-13

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 65.26  E-value: 5.05e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  194 IAALHGLEETKKLANKYLV---------EDVLLLNFEEMRALLDSLPPPVESELALFQMSVLWLEHDRETRMQYAPDLMK 264
Cdd:pfam07707   7 FADAYGCTELAEAALRFILqnflevaksEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKHLPELLS 86

                          90
                  ....*....|....*..
gi 569003631  265 RLRFALIPAPELVERVQ 281
Cdd:pfam07707  87 AVRLPLLSPQYLLNLVE 103
PHA02713 PHA02713
hypothetical protein; Provisional
 12-480 8.43e-13

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 71.19  E-value: 8.43e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  12 DPSHSDNLLHGLNLLWRKQLFCDVTLT-AQGQQFHCHKAVLASCSQYFRSLFsshpplgggvggqdglgapkdqqqqqqp 90
Cdd:PHA02713   5 DIKHNRRVVSNISNLLDDDILCDVIITiGDGEEIKAHKTILAAGSKYFRTLF---------------------------- 56

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  91 qqqppqqqqpppqeepgtpssspddkllTSPRAINNLV----LQGCSSIGLRLVLEYLYtaNVTLSLDTVEEVLSVSKIL 166
Cdd:PHA02713  57 ----------------------------TTPMIIRDLVtrvnLQMFDKDAVKNIVQYLY--NRHISSMNVIDVLKCADYL 106

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 167 HIPQVTKLCVQFLNDQISvqnyKQVCkIAALHGLEETKKLANKYLVEDVLLLNFEEM-----------RALLDSLPPPVE 235
Cdd:PHA02713 107 LIDDLVTDCESYIKDYTN----HDTC-IYMYHRLYEMSHIPIVKYIKRMLMSNIPTLittdafkktvfEILFDIISTNDN 181

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 236 SELAL--FQMSVL--WLEHDRETRMQY--------APDLMKRLRFALIpapelvervqSVDFMRTDPVCQKLLLD-AMNY 302
Cdd:PHA02713 182 VYLYRegYKVTILlkWLEYNYITEEQLlcilscidIQNLDKKSRLLLY----------SNKTINMYPSCIQFLLDnKQNR 251

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 303 HLMPfRQHCRQSLASRIRSNKKMLLLvgglppgpdrlpsnlvqyYDDEKKTWKILTIMPYNSAHHCVVEVENFLFVLGGE 382
Cdd:PHA02713 252 NIIP-RQLCLVCHDTKYNVCNPCILV------------------YNINTMEYSVISTIPNHIINYASAIVDNEIIIAGGY 312

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 383 DQWNPngkhSTNFVSRYDPRFNSWIQLPPMQERRASFYACRLDKHLYVIGGRNETGYLSSVECYNLDTNEWRYVSSLPQP 462
Cdd:PHA02713 313 NFNNP----SLNKVYKINIENKIHVELPPMIKNRCRFSLAVIDDTIYAIGGQNGTNVERTIECYTMGDDKWKMLPDMPIA 388

                        490
                 ....*....|....*...
gi 569003631 463 LAAHAGAVHNGKIYISGG 480
Cdd:PHA02713 389 LSSYGMCVLDQYIYIIGG 406
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 415-460 2.64e-11

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 58.78  E-value: 2.64e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 569003631  415 RRASFYACRLDKHLYVIGGRNETGYLSSVECYNLDTNEWRYVSSLP 460
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 562-604 1.80e-05

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 42.21  E-value: 1.80e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 569003631  562 RSGPGCAVLDDSIYLVGGysWSMGAYKSSTICYCPEKGTWTEL 604
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGG--FDGNQSLNSVEVYDPETNTWSKL 42
muta_rot_YjhT TIGR03547
mutatrotase, YjhT family; Members of this protein family contain multiple copies of the ...
 459-580 3.88e-04

mutatrotase, YjhT family; Members of this protein family contain multiple copies of the beta-propeller-forming Kelch repeat. All are full-length homologs to YjhT of Escherichia coli, which has been identified as a mutarotase for sialic acid. This protein improves bacterial ability to obtain host sialic acid, and thus serves as a virulence factor. Some bacteria carry what appears to be a cyclically permuted homolog of this protein.


Pssm-ID: 274641 [Multi-domain]  Cd Length: 346  Bit Score: 43.08  E-value: 3.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  459 LPQPLAAHAGAVHNGKIYI---SGGVHngeyvpWLYCYDPVMDV-WARKQDMNT-KRAIHTLAVMNDRLYAIGG---NHL 530
Cdd:TIGR03547   4 LPVGFKNGTGAIIGDKVYVglgSAGTS------WYKLDLKKPSKgWQKIADFPGgPRNQAVAAAIDGKLYVFGGigkANS 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 569003631  531 KGFSHLdVMLVECYDPKGDQWNILQTPILEGRSGPGCAVLDDS-IYLVGGY 580
Cdd:TIGR03547  78 EGSPQV-FDDVYRYDPKKNSWQKLDTRSPVGLLGASGFSLHNGqAYFTGGV 127
 
Name Accession Description Interval E-value
BTB_POZ_KLHL14_printor cd18243
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1-190 1.03e-70

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14); KLHL14 is also called protein interactor of Torsin-1A (TOR1A), protein interactor of torsinA, or Printor. It is a novel torsinA-interacting protein that preferentially interacts with ATP-free form of TOR1A and is implicated in dystonia pathogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349552 [Multi-domain]  Cd Length: 130  Bit Score: 224.53  E-value: 1.03e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631   1 MSRSGDRTSTFDPSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSshpplgggvggqdglga 80
Cdd:cd18243    1 MSRSGDRTSTFDPSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFS----------------- 63

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  81 pkdqqqqqqpqqqppqqqqpppqeepgtpssspddklltspraINNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVL 160
Cdd:cd18243   64 -------------------------------------------INNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVL 100

                        170       180       190
                 ....*....|....*....|....*....|
gi 569003631 161 SVSKILHIPQVTKLCVQFLNDQISVQNYKQ 190
Cdd:cd18243  101 SVSKILHIPQVTKLCVQFLNDQISVQNYKQ 130
BACK_KLHL14 cd18453
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 14 (KLHL14); KLHL14, also ...
 183-284 5.63e-69

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 14 (KLHL14); KLHL14, also termed protein interactor of Torsin-1A, or Printor, or protein interactor of torsinA, is a novel ATP-free form of torsinA-interacting protein implicated in dystonia pathogenesis.


Pssm-ID: 350528  Cd Length: 102  Bit Score: 219.12  E-value: 5.63e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 183 ISVQNYKQVCKIAALHGLEETKKLANKYLVEDVLLLNFEEMRALLDSLPPPVESELALFQMSVLWLEHDRETRMQYAPDL 262
Cdd:cd18453    1 ISVQNYKQVCKIAALHGLEETKKLANKYLVEDVLLLNFEEMRAMLDSLPPPVESELALFQMSVLWLEHDRETRMQYAPDL 80

                         90       100
                 ....*....|....*....|..
gi 569003631 263 MKRLRFALIPAPELVERVQSVD 284
Cdd:cd18453   81 MKRLRFALIPAPELVERVQSVD 102
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
326-579 1.42e-47

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 168.41  E-value: 1.42e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 326 LLLVGGLPPGpdrLPSNLVQYYDDEKKTWKILTIMPYNSAHH-CVVEVENFLFVLGGEDQWNPNGKHSTNfVSRYDPRFN 404
Cdd:COG3055   25 VYVAGGLSGG---SASNSFEVYDPATNTWSELAPLPGPPRHHaAAVAQDGKLYVFGGFTGANPSSTPLND-VYVYDPATN 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 405 SWIQLPPMQERRASFYACRLDKHLYVIGGRNETGYLSSVECYNLDTNEWRYVSSLPQPLAAHAGAVH-NGKIYISGGVHN 483
Cdd:COG3055  101 TWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDHLAAAVLpDGKILVIGGRNG 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 484 GEYVpwlycydpvmDVWARKQDMNTKRAIHTLAVMNDRLYAIGGNHlkGFSHLdvmlVECYDPKGDQWNILqTPILEGRS 563
Cdd:COG3055  181 SGFS----------NTWTTLAPLPTARAGHAAAVLGGKILVFGGES--GFSDE----VEAYDPATNTWTAL-GELPTPRH 243

                        250
                 ....*....|....*.
gi 569003631 564 GPGCAVLDDSIYLVGG 579
Cdd:COG3055  244 GHAAVLTDGKVYVIGG 259
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
353-620 2.11e-46

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 165.33  E-value: 2.11e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 353 TWKILTIMPYNSAHHCVVEVENFLFVLGGEDQWNPngkhsTNFVSRYDPRFNSWIQLPPMQERRASFYACRL-DKHLYVI 431
Cdd:COG3055    2 TWSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSA-----SNSFEVYDPATNTWSELAPLPGPPRHHAAAVAqDGKLYVF 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 432 GGRNE----TGYLSSVECYNLDTNEWRYVSSLPQPLAAHAGAVHNGKIYISGGVHNGEYVPWLYCYDPVMDVWARKQDMN 507
Cdd:COG3055   77 GGFTGanpsSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLP 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 508 TKRAIHTLAVM-NDRLYAIGGNHLKGFShldvmlvecydpkgDQWNILQtPILEGRSGPGCAVLDDSIYLVGGYS-WSMG 585
Cdd:COG3055  157 TPRDHLAAAVLpDGKILVIGGRNGSGFS--------------NTWTTLA-PLPTARAGHAAAVLGGKILVFGGESgFSDE 221

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 569003631 586 AYksstiCYCPEKGTWTELeGDVAEPLAGPACATV 620
Cdd:COG3055  222 VE-----AYDPATNTWTAL-GELPTPRHGHAAVLT 250
PHA03098 PHA03098
kelch-like protein; Provisional
 140-602 3.32e-44

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 165.71  E-value: 3.32e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 140 VLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQNYKQVCKIAALHGLeetKKLANK---------- 209
Cdd:PHA03098  62 VIKYIYTGKINITSNNVKDILSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGC---KKLYSAaynyirnnie 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 210 --YLVEDVLLLNFEEMRALLDSLPPPVESELALFQMSVLWLEHDRETRMQYAPDLMKRLRFALIpAPELVERVqsvdfmr 287
Cdd:PHA03098 139 liYNDPDFIYLSKNELIKILSDDKLNVSSEDVVLEIIIKWLTSKKNNKYKDICLILKVLRITFL-SEEGIKKL------- 210

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 288 tdpvcqKLLLDAMNYHLMPFRQHCRQSLASRIRSNKKMLLLVGGLP------PGPDRLPSNLVQYYDDEKKTWKILTImP 361
Cdd:PHA03098 211 ------KRWKLRIKKKKIVFNKRCIKIIYSKKYNLNKILPRSSTFGsiiyihITMSIFTYNYITNYSPLSEINTIIDI-H 283

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 362 YNSAHHCVVEvENFLFVLGGEDQWNpngkHSTNFVSRYDPRFNSWIQLPPMQERRASFYACRLDKHLYVIGGRNETGYLS 441
Cdd:PHA03098 284 YVYCFGSVVL-NNVIYFIGGMNKNN----LSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISLN 358

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 442 SVECYNLDTNEWRYVSSLPQPLAAHAGAVHNGKIYISGGVH-NGEYVPWLYCYDPVMDVWARKQDMNTKRAIHTLAVMND 520
Cdd:PHA03098 359 TVESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGGISkNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDG 438

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 521 RLYAIGgnhlkGFSHLDVML----VECYDPKGDQWNILqTPILEGRSGPGCAVLDDSIYLVGGYswsMGAYKSSTI-CYC 595
Cdd:PHA03098 439 KIYVIG-----GISYIDNIKvyniVESYNPVTNKWTEL-SSLNFPRINASLCIFNNKIYVVGGD---KYEYYINEIeVYD 509


                 ....*..
gi 569003631 596 PEKGTWT 602
Cdd:PHA03098 510 DKTNTWT 516
BTB_POZ_KLHL26 cd18255
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-187 7.04e-27

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349564 [Multi-domain]  Cd Length: 121  Bit Score: 105.55  E-value: 7.04e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSShpplgggvggqdglgapkdqqqqqqpqqqp 94
Cdd:cd18255    1 HSVTLLQGLNALRAKGQLLDVTLIADGQRFQAHKVVLASCSDYFRAMFTG------------------------------ 50

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  95 pqqqqpppqeepGTPSSSPDDklltsprainnLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKL 174
Cdd:cd18255   51 ------------GMRESSQDE-----------IELKGVSAKGLKHILDFAYTSELTLDLDCIQDVLGAAVHLQMLPVVEL 107

                        170
                 ....*....|...
gi 569003631 175 CVQFLNDQISVQN 187
Cdd:cd18255  108 CEEFLKSAMSVEN 120
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 23-183 1.82e-20

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 86.93  E-value: 1.82e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631   23 LNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHPplgggvggqdglgapkdqqqqqqpqqqppqqqqppp 102
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQE------------------------------------ 44

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  103 qeepgtpssspddklltSPRAINNLVLQGCSSIGLRLVLEYLYTANvTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQ 182
Cdd:pfam00651  45 -----------------SESSVSEITLDDVSPEDFEALLEFMYTGK-LISEENVDDLLAAADKLQIPSLVDKCEEFLIKS 106


                  .
gi 569003631  183 I 183
Cdd:pfam00651 107 L 107
BTB_POZ_KLHL21 cd18250
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 12-187 3.30e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349559 [Multi-domain]  Cd Length: 124  Bit Score: 86.75  E-value: 3.30e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  12 DPSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSshpplgggvggqdglgapkdqqqqqqpq 91
Cdd:cd18250    1 DPAHALHLLRGLSELRAERKFFDVTLCAGGREFPCHRTVLAAASSYFRAMFA---------------------------- 52

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  92 qqppqqqqpppqeepGTPSSSPDDKlltsprainnLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQV 171
Cdd:cd18250   53 ---------------GELRESRADR----------VVLHGVSAEILGLLLDFSYTGRVTVTQDNVEALLRAADLFQFPSV 107

                        170
                 ....*....|....*.
gi 569003631 172 TKLCVQFLNDQISVQN 187
Cdd:cd18250  108 KEACCAYLQQRLDVSN 123
BTB_POZ_KLHL35 cd18265
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-187 1.81e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349574 [Multi-domain]  Cd Length: 128  Bit Score: 84.82  E-value: 1.81e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  13 PSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHpplgggvggqdglgapkdqqqqqqpqq 92
Cdd:cd18265    4 PCHAERILQVLNAYRRSGTFTDVVLLVDGKDFPCHRATLSANSAYFRAMFGGH--------------------------- 56

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  93 qppqqqqpppqeepgTPSSSPDdklltsprAINnlvLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVT 172
Cdd:cd18265   57 ---------------LKESRQA--------VVE---IQKVSAAAMEVLLDYMYGGGLRIQEDNVESVLEASDLLQVSKLR 110

                        170
                 ....*....|....*
gi 569003631 173 KLCVQFLNDQISVQN 187
Cdd:cd18265  111 EACVRFLEGQLHPCN 125
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 32-166 3.67e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 82.22  E-value: 3.67e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  32 FCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHpplgggvggqdglgapkdqqqqqqpqqqppqqqqpppqeepgtpss 111
Cdd:cd18186    1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSG---------------------------------------------- 34

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 569003631 112 spddkllTSPRAINNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKIL 166
Cdd:cd18186   35 -------MKESSSSEIELDDVSPEAFEALLDYIYTGELELSEENVEELLAAADKL 82
BTB_POZ_KLHL32 cd18261
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-188 8.08e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349570 [Multi-domain]  Cd Length: 133  Bit Score: 80.01  E-value: 8.08e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  14 SHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSshpplgggvggqdglgapkdqqqqqqpqqq 93
Cdd:cd18261   10 SHKDAVLAALNQQRNDGILCDITLVAEEQKFHAHKAVLAACSDYFRAMFS------------------------------ 59

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  94 ppqqqqpppqeepgtpssspddkLLTSPRAINNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTK 173
Cdd:cd18261   60 -----------------------LCMVESEADEVNLHGVTSLGLKQALDFAYTGQILLEPGVIQDVLAAGSHLQLLELLS 116

                        170
                 ....*....|....*
gi 569003631 174 LCVQFLNDQISVQNY 188
Cdd:cd18261  117 LCSHYLIQELNSFNY 131
BTB_POZ_KLHL31_KBTBD1 cd18260
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-187 3.67e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349569 [Multi-domain]  Cd Length: 120  Bit Score: 77.93  E-value: 3.67e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHPplgggvggqdglgapkdqqqqqqpqqqp 94
Cdd:cd18260    1 YGANLLEGLNRMRQERFLCDLTIATKTKSFDVHKVVMASCSEYFRNILKKDP---------------------------- 52

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  95 pqqqqpppqeepgtpssspddklltsprAINNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKL 174
Cdd:cd18260   53 ----------------------------SLQRVELNDISPLGLATVITYAYTGKLTLSLYTIGSTISAASYLQIHALVKM 104

                        170
                 ....*....|...
gi 569003631 175 CVQFLNDQISVQN 187
Cdd:cd18260  105 CCDFLMQEMNVEN 117
BTB_POZ_KLHL28_BTBD5 cd18257
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-183 8.71e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349566 [Multi-domain]  Cd Length: 118  Bit Score: 76.81  E-value: 8.71e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHpplgggvggqdglgapkdqqqqqqpqqqp 94
Cdd:cd18257    1 HSEQLLQGLNLLRQHHELCDVVLRVGDVKIHAHKVVLASCSPYFKAMFTGN----------------------------- 51

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  95 pqqqqpppqeepgtpssspddkllTSPRAINNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKL 174
Cdd:cd18257   52 ------------------------LSEKENSEVEFQCIDETALQAIVEYAYTGTVFISQATVESLLPAANLLQIKLVLKE 107


                 ....*....
gi 569003631 175 CVQFLNDQI 183
Cdd:cd18257  108 CCDFLESQL 116
BTB_POZ_KLHL34 cd18264
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-187 7.53e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349573 [Multi-domain]  Cd Length: 136  Bit Score: 74.45  E-value: 7.53e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  14 SHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHpplgggvggqdglgapkdqqqqqqpqqq 93
Cdd:cd18264   10 SHGEAVLSQYQSLRAEGFLCDVVLEAEGNEFPAHRSLLACSSDYFRALFKDY---------------------------- 61

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  94 ppqqqqpppqeepgtpssspddkllTSPRAINNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTK 173
Cdd:cd18264   62 -------------------------TQESKARVIHLPVVSAAGLQRVLDFIYTSWLSLSLDTLEDTLEAASYLQVTEAIG 116

                        170
                 ....*....|....
gi 569003631 174 LCVQFLNDQISVQN 187
Cdd:cd18264  117 LCSQYLINNLAPEN 130
BTB_POZ_ZBTB7A cd18326
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-180 8.21e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349635 [Multi-domain]  Cd Length: 120  Bit Score: 73.82  E-value: 8.21e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  13 PSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSShpplgggvggqdglgapkdqqqqqqpqq 92
Cdd:cd18326    6 PDHSSDILSSLNEQRTQGLLCDVVILVEGREFPTHRSVLAACSQYFKKLFTS---------------------------- 57

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  93 qppqqqqpppqeepgtpSSSPDDKlltspraiNNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVT 172
Cdd:cd18326   58 -----------------GAVVDQQ--------NVYEIDFVSAEALTALLDFAYTATLTVSTSNVGDILSAARLLEIPAVS 112


                 ....*...
gi 569003631 173 KLCVQFLN 180
Cdd:cd18326  113 HVCADLLD 120
BACK_KLHL3 cd18513
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as ...
 195-303 2.57e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as a substrate adapter in Cullin3 (Cul3) E3 ubiquitin ligase complexes. It is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation.


Pssm-ID: 350588 [Multi-domain]  Cd Length: 130  Bit Score: 72.79  E-value: 2.57e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 195 AALHGLEETKKLANKY---------LVEDVLLLNFEEMRALLDSLPPPVESELALFQMSVLWLEHDRETRMQYAPDLMKR 265
Cdd:cd18513   13 ADVHTCTELLQQANAYaeqhfpevmLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISWIKYDKEARLEHMAKLMEH 92

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 569003631 266 LRFALIPAPELVERVQSVDFMRTDPVCQKLLLDAMNYH 303
Cdd:cd18513   93 VRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKYH 130
BTB_POZ_ZBTB44 cd18228
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-183 2.89e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349537 [Multi-domain]  Cd Length: 126  Bit Score: 72.59  E-value: 2.89e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  14 SHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHPplgggvggqdglgapkdqqqqqqpqqq 93
Cdd:cd18228    1 SHSQELLGKLNSLRNEGHFCDVTIRVQDKIFRAHKVVLAACSDFFRSKLVGQA--------------------------- 53

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  94 ppqqqqpppqeEPGTPSSSPDDKLLTSpraINNLVLQGCSSIglrlvLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTK 173
Cdd:cd18228   54 -----------SPRLVLVSPAGKCVLD---LHHVTVTGFAPL-----LEYAYTSTLSINTENIIDVLAAASYMQMFNVAN 114

                        170
                 ....*....|
gi 569003631 174 LCVQFLNDQI 183
Cdd:cd18228  115 TCSEFMKSSI 124
BTB_POZ_ZBTB7B_ZBTB15 cd18327
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-179 3.24e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349636 [Multi-domain]  Cd Length: 127  Bit Score: 72.57  E-value: 3.24e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  13 PSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHPplgggvggqdglgapkdqqqqqqpqq 92
Cdd:cd18327    6 PEHSSELLSCLNEQRRAGLLCDLTIKTRGLEYRTHRAVLAACSLYFRKLFTGGG-------------------------- 59

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  93 qppqqQQPPPQEEPGTPSSSPDDklLTSPRAINNLvlqgcssiglrlvLEYLYTANVTLSLDTVEEVLSVSKILHIPQVT 172
Cdd:cd18327   60 -----GGSGDLGAGGGQDVCELD--FVGPEALGAL-------------LEFAYTATLTISSSNMREVLRAARLLEIPCVA 119


                 ....*..
gi 569003631 173 KLCVQFL 179
Cdd:cd18327  120 DACADIL 126
BTB_POZ_KLHL2-like cd18235
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-183 4.76e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349544 [Multi-domain]  Cd Length: 121  Bit Score: 71.69  E-value: 4.76e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  13 PSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHpplgggvggqdglgapkdqqqqqqpqq 92
Cdd:cd18235    2 PQHTQKAFDVMNELRKQNLLCDVILVADGVEIPAHRVVLASCSPYFHAMFTGD--------------------------- 54

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  93 qppqqqqpppqeepgtpssspddklLTSPRAiNNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVT 172
Cdd:cd18235   55 -------------------------LSESRA-NRVTLQDVDGKALLLLIDYVYTAEIQVTEENVQVLLPAANLLQLTDVR 108

                        170
                 ....*....|.
gi 569003631 173 KLCVQFLNDQI 183
Cdd:cd18235  109 DACCDFLQSQL 119
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-187 5.53e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 71.67  E-value: 5.53e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSshpplgggvggqdglgapkdqqqqqqpqqqp 94
Cdd:cd18256    3 HASLILAQLNKLRGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALFA------------------------------- 51

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  95 pqqqqpppqeePGTPSSSPDDklltsprainnLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKL 174
Cdd:cd18256   52 -----------GGMSESSKDV-----------VQIHGVEPDIFHILLDFIYTGVVEVTVSNVQELLVAADMLQLTEVVEI 109

                        170
                 ....*....|...
gi 569003631 175 CVQFLNDQISVQN 187
Cdd:cd18256  110 CCEFLKGQLHPSN 122
BTB_POZ_KLHL10 cd18240
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 16-187 1.31e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349549 [Multi-domain]  Cd Length: 120  Bit Score: 70.43  E-value: 1.31e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  16 SDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHpplgggvggqdglgapkdqqqqqqpqqqpp 95
Cdd:cd18240    1 SAMACNVFNELRLEGKLCDVVIRVNGVEFPAHRNILCACSPYFRALFTNG------------------------------ 50

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  96 qqqqpppqeepgtpSSSPDDKLLTSPrainnlvlqGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLC 175
Cdd:cd18240   51 --------------WNETEKKVYKIP---------GVSPEMMELIIEYAYTRTVPITAENVEELLPAADQFNIMGIVKAC 107

                        170
                 ....*....|..
gi 569003631 176 VQFLNDQISVQN 187
Cdd:cd18240  108 CDFLEDQLCPEN 119
BTB_POZ_NS1BP cd18306
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-187 1.62e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349615 [Multi-domain]  Cd Length: 124  Bit Score: 70.37  E-value: 1.62e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSShpplgggvggqdglgapkdqqqqqqpqqqp 94
Cdd:cd18306    1 HPESVLAKLNALRKNRQFCDVILQVGGHEIPAHRAVLACASPYLFELFSS------------------------------ 50

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  95 pqqqqpppqEEPGTPssspddklltspraINNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKL 174
Cdd:cd18306   51 ---------DSDGES--------------ILTVKLDGLDPDAVEVLVNYAYTSRLEVPADLVKSVYSAAKKLKMDRVKKA 107

                        170
                 ....*....|...
gi 569003631 175 CVQFLNDQISVQN 187
Cdd:cd18306  108 CGDFLLEKLTPQN 120
BTB_POZ_ZBTB7 cd18198
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-179 2.84e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349507 [Multi-domain]  Cd Length: 120  Bit Score: 69.51  E-value: 2.84e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  13 PSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSShpplgggvggqdglgapkdqqqqqqpqq 92
Cdd:cd18198    6 PDHSSEILSGLNEQRTQGLLCDVVILVQGREYRTHRSVLAACSQYFKKLFTS---------------------------- 57

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  93 qppqqqqpppqeepGTPSSSPD--DKLLTSPRAINNLvlqgcssiglrlvLEYLYTANVTLSLDTVEEVLSVSKILHIPQ 170
Cdd:cd18198   58 --------------GAVVDQQNvyEIDFVSPEALTAL-------------LEFAYTATLTVSTANVGDILSAARLLEIPC 110


                 ....*....
gi 569003631 171 VTKLCVQFL 179
Cdd:cd18198  111 VSHVCAEIL 119
BACK_KLHL2_Mayven cd18512
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also ...
 195-303 3.90e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation.


Pssm-ID: 350587 [Multi-domain]  Cd Length: 130  Bit Score: 69.67  E-value: 3.90e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 195 AALHGLEETKKLANKY---------LVEDVLLLNFEEMRALLDSLPPPVESELALFQMSVLWLEHDRETRMQYAPDLMKR 265
Cdd:cd18512   13 ADMHACTELLNQANTYaeqhfsdvvLSEEFLNLGIEQVCSLIASDKLTISSEEKVFEAVIAWVNHDKEVRQEHMAHLMEH 92

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 569003631 266 LRFALIPAPELVERVQSVDFMRTDPVCQKLLLDAMNYH 303
Cdd:cd18512   93 VRLPLLSREYLVQRVEEETLVKNSSACKDYLIEAMKYH 130
BTB_POZ_KLHL16_gigaxonin cd18245
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-179 4.23e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349554 [Multi-domain]  Cd Length: 111  Bit Score: 68.91  E-value: 4.23e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  19 LLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHPPlgggvggqdglgapkdqqqqqqpqqqppqqq 98
Cdd:cd18245    1 LLRALNSFREEPHLCDATLVVGGEEIPVQKNVLAAASPYFRAKLNYNPP------------------------------- 49

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  99 qpppqEEPGTPSSspddklltsprainnLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQF 178
Cdd:cd18245   50 -----KDDGSTYK---------------IELEGISVEVMEEILDYIYTGQIKLSEDNIQDIVQAADLLLMTDLKDLCCEF 109


                 .
gi 569003631 179 L 179
Cdd:cd18245  110 L 110
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 191-279 5.75e-14

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 68.14  E-value: 5.75e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631   191 VCKIAALHGLEETKKLANKYLV---------EDVLLLNFEEMRALL--DSLPppVESELALFQMSVLWLEHDRETRMQYA 259
Cdd:smart00875   4 IRRFADAHGLEELAEKALRFILqnfsevsssEEFLELPLEQLLELLssDDLN--VSSEEEVFEAVLRWVKHDPEKRREHL 81

                           90       100
                   ....*....|....*....|
gi 569003631   260 PDLMKRLRFALIPAPELVER 279
Cdd:smart00875  82 PELLEHVRLPLLSPDYLLEV 101
BTB_POZ_KLHL36 cd18266
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-188 8.62e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349575 [Multi-domain]  Cd Length: 135  Bit Score: 68.76  E-value: 8.62e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSshpplgggvggqdglgapkdqqqqqqpqqqp 94
Cdd:cd18266    8 HSNLVLQGLNEQRQRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFT------------------------------- 56

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  95 pqqqqpppqeepgtpssspddklLTSPRAINNLV-LQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTK 173
Cdd:cd18266   57 -----------------------IGMREAHQKEVeLVGASYIGLKAVIDFLYSSELPLDGGNIDYVLETAHLLQIWKVVD 113

                        170
                 ....*....|....*
gi 569003631 174 LCVQFLNDQISVQNY 188
Cdd:cd18266  114 FCCEYLENEVSEENY 128
BTB_POZ_ZBTB17_MIZ1 cd18206
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-178 1.08e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349515 [Multi-domain]  Cd Length: 112  Bit Score: 67.65  E-value: 1.08e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  13 PSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHpplgggvggqdglgapKDQQQqqqpqq 92
Cdd:cd18206    3 PQHSQHVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFRMLFVDQ----------------KDVVH------ 60

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  93 qppqqqqpppqeepgtpssspddklltsprainnlvLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVT 172
Cdd:cd18206   61 ------------------------------------LDISNAAGLGQVLEFMYTAKLSLSPENVDDVLAVATFLQMQDIV 104


                 ....*.
gi 569003631 173 KLCVQF 178
Cdd:cd18206  105 TACHAL 110
PHA03098 PHA03098
kelch-like protein; Provisional
 342-460 1.31e-13

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 73.65  E-value: 1.31e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 342 NLVQYYDDEKKTWKILTIMPYNSAHHCVVEVENFLFVLGGEDqwNPNGKHSTNFVSRYDPRFNSWIQLPPMQERRASFYA 421
Cdd:PHA03098 406 KTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGIS--YIDNIKVYNIVESYNPVTNKWTELSSLNFPRINASL 483

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 569003631 422 CRLDKHLYVIGGRNETGYLSSVECYNLDTNEWRYVSSLP 460
Cdd:PHA03098 484 CIFNNKIYVVGGDKYEYYINEIEVYDDKTNTWTLFCKFP 522
BTB_POZ_KBTBD2_BKLHD1 cd18270
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-187 1.38e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349579 [Multi-domain]  Cd Length: 133  Bit Score: 68.10  E-value: 1.38e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  18 NLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSShpplgggvggqdglgapkdqqqqqqpqqqppqq 97
Cdd:cd18270   12 SLLEQLKFFYEQQLLTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMS--------------------------------- 58

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  98 qqpppqeepGTPSSSPddklltspraiNNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQ 177
Cdd:cd18270   59 ---------GLSESKQ-----------THVHLRNVDAATLQIIITYAYTGNLAINDSTVEQLYETACFLQVEDVLQRCRE 118

                        170
                 ....*....|
gi 569003631 178 FLNDQISVQN 187
Cdd:cd18270  119 YLIKKINAEN 128
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-187 1.87e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 67.31  E-value: 1.87e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  23 LNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSShpplgggvggqdglgapkdqqqqqqpqqqppqqqqppp 102
Cdd:cd18238    6 LHQFYENGELCDVTLKVGEKSIHCHRLVLACVSPYFRAMFTS-------------------------------------- 47

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 103 qeePGTPSSSpddklltspraiNNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQ 182
Cdd:cd18238   48 ---EMAESKQ------------DSITIKDIDEEAVELLVDFAYTGKLTLTVDNVQSLLYAASLLQVEEVAKACCEFMKDH 112


                 ....*
gi 569003631 183 ISVQN 187
Cdd:cd18238  113 LHPSN 117
Kelch smart00612
Kelch domain;
427-473 2.82e-13

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 64.12  E-value: 2.82e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 569003631   427 HLYVIGGRNETGYLSSVECYNLDTNEWRYVSSLPQPLAAHAGAVHNG 473
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 34-183 4.13e-13

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 65.40  E-value: 4.13e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631    34 DVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHPplgggvggqdglgapkdqqqqqqpqqqppqqqqpppqeepgtpssSP 113
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDF---------------------------------------------KE 35

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631   114 DDKlltspraiNNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQI 183
Cdd:smart00225  36 SDK--------SEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYLQIPGLVELCEEFLLKLL 97
BTB_POZ_ZBTB7C_ZBTB36 cd18328
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-180 4.68e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349637 [Multi-domain]  Cd Length: 120  Bit Score: 66.06  E-value: 4.68e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  13 PSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSShpplgggvggqdglgapkdqqqqqqpqq 92
Cdd:cd18328    6 PNHSSEVLCSLNEQRHDGLLCDVVLIVQDQEYRTHRSVLAACSKYFKKLFTA---------------------------- 57

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  93 qppqqqqpppqeepGTPSSSPD--DKLLTSPRAinnlvlqgcssigLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQ 170
Cdd:cd18328   58 --------------GTLADQPYvyEIDFVTPEA-------------LSAILEFAYTSTLTITTSNVKHILNAAQMLEIQC 110

                        170
                 ....*....|
gi 569003631 171 VTKLCVQFLN 180
Cdd:cd18328  111 IINVCLEIMD 120
PLN02193 PLN02193
nitrile-specifier protein
 347-527 4.72e-13

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 71.53  E-value: 4.72e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 347 YDDEKKTWKILTI---MPYNSAHH-CVVEVENFLFVLGGED---QWNpngkhstNFVSrYDPRFNSWIQLPPMQERRA-- 417
Cdd:PLN02193 198 FDLETRTWSISPAtgdVPHLSCLGvRMVSIGSTLYVFGGRDasrQYN-------GFYS-FDTTTNEWKLLTPVEEGPTpr 269

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 418 SFYACRLDK-HLYVIGGRNETGYLSSVECYNLDTNEWRYVSSLPQPLAAHAGA---VHNGKIYISGGVhNGEYVPWLYCY 493
Cdd:PLN02193 270 SFHSMAADEeNVYVFGGVSATARLKTLDSYNIVDKKWFHCSTPGDSFSIRGGAgleVVQGKVWVVYGF-NGCEVDDVHYY 348

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 569003631 494 DPVMDVWARKQDMNTK---RAIHTLAVMNDRLYAIGG 527
Cdd:PLN02193 349 DPVQDKWTQVETFGVRpseRSVFASAAVGKHIVIFGG 385
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 194-281 5.05e-13

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 65.26  E-value: 5.05e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  194 IAALHGLEETKKLANKYLV---------EDVLLLNFEEMRALLDSLPPPVESELALFQMSVLWLEHDRETRMQYAPDLMK 264
Cdd:pfam07707   7 FADAYGCTELAEAALRFILqnflevaksEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKHLPELLS 86

                          90
                  ....*....|....*..
gi 569003631  265 RLRFALIPAPELVERVQ 281
Cdd:pfam07707  87 AVRLPLLSPQYLLNLVE 103
BTB_POZ_KLHL30 cd18259
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-187 6.60e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349568 [Multi-domain]  Cd Length: 137  Bit Score: 66.01  E-value: 6.60e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  13 PSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSShpplgggvggqdglgapkdqqqqqqpqq 92
Cdd:cd18259   13 PSHPQSILDGLQTLRSNPKLSDVTLLVGGREFPCHRSVLALCSHYFNAMFTG---------------------------- 64

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  93 qppqqqqpppqeepgtpssspddKLLTSPRAinNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVT 172
Cdd:cd18259   65 -----------------------DFVESISA--RVEIKDVDPAVMESLIDFAYTGKLTINQGNVEALIRTSNRLQFPTVR 119

                        170
                 ....*....|....*
gi 569003631 173 KLCVQFLNDQISVQN 187
Cdd:cd18259  120 KVCSRYLQQQIDATN 134
PHA02713 PHA02713
hypothetical protein; Provisional
 12-480 8.43e-13

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 71.19  E-value: 8.43e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  12 DPSHSDNLLHGLNLLWRKQLFCDVTLT-AQGQQFHCHKAVLASCSQYFRSLFsshpplgggvggqdglgapkdqqqqqqp 90
Cdd:PHA02713   5 DIKHNRRVVSNISNLLDDDILCDVIITiGDGEEIKAHKTILAAGSKYFRTLF---------------------------- 56

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  91 qqqppqqqqpppqeepgtpssspddkllTSPRAINNLV----LQGCSSIGLRLVLEYLYtaNVTLSLDTVEEVLSVSKIL 166
Cdd:PHA02713  57 ----------------------------TTPMIIRDLVtrvnLQMFDKDAVKNIVQYLY--NRHISSMNVIDVLKCADYL 106

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 167 HIPQVTKLCVQFLNDQISvqnyKQVCkIAALHGLEETKKLANKYLVEDVLLLNFEEM-----------RALLDSLPPPVE 235
Cdd:PHA02713 107 LIDDLVTDCESYIKDYTN----HDTC-IYMYHRLYEMSHIPIVKYIKRMLMSNIPTLittdafkktvfEILFDIISTNDN 181

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 236 SELAL--FQMSVL--WLEHDRETRMQY--------APDLMKRLRFALIpapelvervqSVDFMRTDPVCQKLLLD-AMNY 302
Cdd:PHA02713 182 VYLYRegYKVTILlkWLEYNYITEEQLlcilscidIQNLDKKSRLLLY----------SNKTINMYPSCIQFLLDnKQNR 251

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 303 HLMPfRQHCRQSLASRIRSNKKMLLLvgglppgpdrlpsnlvqyYDDEKKTWKILTIMPYNSAHHCVVEVENFLFVLGGE 382
Cdd:PHA02713 252 NIIP-RQLCLVCHDTKYNVCNPCILV------------------YNINTMEYSVISTIPNHIINYASAIVDNEIIIAGGY 312

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 383 DQWNPngkhSTNFVSRYDPRFNSWIQLPPMQERRASFYACRLDKHLYVIGGRNETGYLSSVECYNLDTNEWRYVSSLPQP 462
Cdd:PHA02713 313 NFNNP----SLNKVYKINIENKIHVELPPMIKNRCRFSLAVIDDTIYAIGGQNGTNVERTIECYTMGDDKWKMLPDMPIA 388

                        490
                 ....*....|....*...
gi 569003631 463 LAAHAGAVHNGKIYISGG 480
Cdd:PHA02713 389 LSSYGMCVLDQYIYIIGG 406
BTB_POZ_KLHL37_ENC1 cd18267
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-63 9.75e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349576 [Multi-domain]  Cd Length: 147  Bit Score: 66.17  E-value: 9.75e-13
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 569003631  13 PSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFS 63
Cdd:cd18267   21 SSYADSVLTHLNLLRQQRLFTDVLLHAGNRSFPCHRAVLAACSRYFEAMFS 71
BTB_POZ_KLHL12_C3IP1_DKIR cd18242
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-187 1.59e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349551 [Multi-domain]  Cd Length: 124  Bit Score: 64.77  E-value: 1.59e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  14 SHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHpplgggvggqdglgapkdqqqqqqpqqq 93
Cdd:cd18242    3 SHAKSILNTMNSLRKSNTLCDVTLRVEGKEFPAHRIVLAACSDYFCAMFTSE---------------------------- 54

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  94 ppqqqqpppqeepgtpssspddkllTSPRAINNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTK 173
Cdd:cd18242   55 -------------------------MSEKGKSEVELQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQ 109

                        170
                 ....*....|....
gi 569003631 174 LCVQFLNDQISVQN 187
Cdd:cd18242  110 ACCEFLESQLDPSN 123
BTB_POZ_KLHL25 cd18254
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-63 1.86e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349563 [Multi-domain]  Cd Length: 128  Bit Score: 64.65  E-value: 1.86e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 569003631  13 PSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFS 63
Cdd:cd18254    3 PSHPDCVLTHLNTLRKQCMFTDVTLWAGNRSFPCHRAVLAACSRYFEAMFS 53
BTB_POZ_KBTBD6_7 cd18273
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 12-187 2.10e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349582 [Multi-domain]  Cd Length: 142  Bit Score: 64.85  E-value: 2.10e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  12 DPSHSDNLLHGLNLLWRKQLFCDVTL--------TAQGQQFHCHKAVLASCSQYFRSLFSshpplgggvggqdglgapkd 83
Cdd:cd18273    6 DAAHARALLAQLKSFYDARLLTDVTIevngpgsgPGSGRLFPCNRNVLAAASPYFKSMFT-------------------- 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  84 qqqqqqpqqqppqqqqpppqeepGTPSSSPDDKlltsprainnLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVS 163
Cdd:cd18273   66 -----------------------GGLYESKQET----------VTIHDVDSESMALIIDYCYTGRVTLSEANVQRLYAAA 112

                        170       180
                 ....*....|....*....|....
gi 569003631 164 KILHIPQVTKLCVQFLNDQISVQN 187
Cdd:cd18273  113 NMLQLEYVREACASFLARRLDLSN 136
BACK_KLHL31_KBTBD1 cd18470
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also ...
 183-271 2.36e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also termed BTB and kelch domain-containing protein 6, or Kelch repeat and BTB domain-containing protein 1, or Kelch-like protein KLHL, is a transcriptional repressor in MAPK/JNK signaling pathway that regulates cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE).


Pssm-ID: 350545  Cd Length: 98  Bit Score: 63.36  E-value: 2.36e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 183 ISVQNYKQVCKIAALHGLEETKKLANKYL---------VEDVLLLNFEEMRALL--DSLPPPveSELALFQMSVLWLEHD 251
Cdd:cd18470    1 INVENCMYVVNIAETYGLKNTKEAAQKFIrdnfiefseTDQFLKLTFEQINEFLidDDLQLP--SEITAFQIAMKWLDFD 78

                         90       100
                 ....*....|....*....|
gi 569003631 252 rETRMQYAPDLMKRLRFALI 271
Cdd:cd18470   79 -QKRVKYAADLLSNIRFGTI 97
BTB_POZ_KLHL9_13 cd18239
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-187 2.39e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13; KLHL9 and KLHL13 (also called BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes, thereby coordinating faithful mitotic progression and completion of cytokinesis. They contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349548 [Multi-domain]  Cd Length: 128  Bit Score: 64.44  E-value: 2.39e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  15 HSDNLLHGLNLLWRKQLFCDVTLTA--QGQQFHCHKAVLASCSQYFRSLFSShpplgggvggqdglgapkdqqqqqqpqq 92
Cdd:cd18239    6 HSSVVLQGFDQLRGEGLLCDVTLVPgdGDETFPVHRAMMASASDYFKAMFTG---------------------------- 57

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  93 qppqqqqpppqeepgtpsSSPDDKLltspRAINnlvLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVT 172
Cdd:cd18239   58 ------------------GMKEQEL----MCIK---LHGVSKIGLKNIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVL 112

                        170
                 ....*....|....*
gi 569003631 173 KLCVQFLNDQISVQN 187
Cdd:cd18239  113 DFCKVLLISGVTLEN 127
BTB_POZ_KLHL23 cd18252
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 12-187 4.90e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349561 [Multi-domain]  Cd Length: 127  Bit Score: 63.31  E-value: 4.90e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  12 DPSHSDNLLHGLNLLWRKQLFCDVTL-TAQGQQFHCHKAVLASCSQYFRSLFSShpplgggvggqdglgapkdqqqqqqp 90
Cdd:cd18252    1 DSSHPADFLDAFRTFYLDGLFTDITLqCASGQIFHCHKAALAACSSYFKVMFTA-------------------------- 54

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  91 qqqppqqqqpppqeepgtpssspDDKlltsPRAINNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQ 170
Cdd:cd18252   55 -----------------------DMK----EKSNNVIKLSGIDHDILEALVNYVYTSQICITERNVQSLLEAADLLQFIS 107

                        170
                 ....*....|....*..
gi 569003631 171 VTKLCVQFLNDQISVQN 187
Cdd:cd18252  108 VKKACEQFLVRHLDIDN 124
BACK_KLHL34 cd18473
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 34 (KLHL34); KLHL34 belongs ...
 194-276 8.75e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 34 (KLHL34); KLHL34 belongs to the KLHL family. Its function remains unclear. The methylation status of KLHL34 cg14232291 may be a predictive candidate of sensitivity to preoperative chemoradiation therapy.


Pssm-ID: 350548  Cd Length: 106  Bit Score: 62.06  E-value: 8.75e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 194 IAALHGLEETKKLANKYLVED-------------VLLLNFEEMRALLDSLPPPVESELALFQMSVLWLEHDrETRMQYAP 260
Cdd:cd18473   12 IAARFGLPDALKAAEKYIISNlwrllasdaddagLLELNLESLQAVLEADDIPRVKESRLLTLVLEWLNQD-ESRLAYAN 90

                         90
                 ....*....|....*.
gi 569003631 261 DLMKRLRFALIPAPEL 276
Cdd:cd18473   91 ALLSRIRYGLVPVEEL 106
BTB_POZ_KLHL7 cd18237
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-187 1.05e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349546 [Multi-domain]  Cd Length: 126  Bit Score: 62.51  E-value: 1.05e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSShpplgggvggqdglgapkdqqqqqqpqqqp 94
Cdd:cd18237    4 LLADFMGVMNNMRKQKTLCDVILIVEGREIKAHRVVLAAASHFFHLMFTS------------------------------ 53

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  95 pqqqqpppqeepgtpssspddKLLTSPRAinNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKL 174
Cdd:cd18237   54 ---------------------NMTESKSS--EVELKDAEPDIIELLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKM 110

                        170
                 ....*....|...
gi 569003631 175 CVQFLNDQISVQN 187
Cdd:cd18237  111 CVDFLKEQLDASN 123
BTB_POZ_KLHL24_KRIP6 cd18253
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-62 1.73e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349562 [Multi-domain]  Cd Length: 121  Bit Score: 61.77  E-value: 1.73e-11
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 569003631  15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLF 62
Cdd:cd18253    1 HSESILQVFNEFRDSRLFTDVIICVEGREFPCHRAILSACSSYFRAMF 48
BTB_POZ_KBTBD8 cd18274
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 12-187 1.89e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349583 [Multi-domain]  Cd Length: 129  Bit Score: 61.93  E-value: 1.89e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  12 DPSHSDNLLHGLNLLWRKQLFCDVTLTA-QGQQFHCHKAVLASCSQYFRSLFSSHPplgggvggqdglgapkdqqqqqqp 90
Cdd:cd18274    2 DPLHACSILQQLKAMYDEGQLTDIVVEVdHGKTFSCHRNVLAAISPYFRSMFTSGL------------------------ 57

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  91 qqqppqqqqpppqeepgTPSSSPDDKLLtsprainnlvlqGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQ 170
Cdd:cd18274   58 -----------------TESTQKEVRIV------------GVEAESMHLVLDYAYTSRVTLTEANVQALFTAASIFQIPS 108

                        170
                 ....*....|....*..
gi 569003631 171 VTKLCVQFLNDQISVQN 187
Cdd:cd18274  109 LQDQCAQFMISRLDPQN 125
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 415-460 2.64e-11

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 58.78  E-value: 2.64e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 569003631  415 RRASFYACRLDKHLYVIGGRNETGYLSSVECYNLDTNEWRYVSSLP 460
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
BTB_POZ_KLHL15 cd18244
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 4-191 3.06e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349553 [Multi-domain]  Cd Length: 137  Bit Score: 61.51  E-value: 3.06e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631   4 SGDRTSTFDPSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHpplgggvggqdglgapkd 83
Cdd:cd18244    2 AGDVEVYNSSIHDTSVSAGFRALYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTAD------------------ 63

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  84 qqqqqqpqqqppqqqqpppqeepgtpssspddkllTSPRAINNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVS 163
Cdd:cd18244   64 -----------------------------------MRERDQDKIHLKGLTATGFSHVLQFMYYGTIELSMLTVHEILQAA 108

                        170       180
                 ....*....|....*....|....*...
gi 569003631 164 KILHIPQVTKLCVQFLNDQISVQNYKQV 191
Cdd:cd18244  109 MYVQLTEVVKFCCSFLLAKICLDNCAEI 136
BTB_POZ_BTBD19 cd18294
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-179 4.27e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349603 [Multi-domain]  Cd Length: 111  Bit Score: 60.34  E-value: 4.27e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  30 QLFCDVT--LTAQGQQFHCHKAVLASCSQYFRSLFSSHPPlgggvggqdglgapkdqqqqqqpqqqppqqqqpppqeepG 107
Cdd:cd18294   12 PEFSDVKflVGPERQEIFAHKCILAARCEVFRAMFLTGPQ---------------------------------------K 52

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 569003631 108 TPSSSPddklltsprainnLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFL 179
Cdd:cd18294   53 ESTQSP-------------LVLSDIEPEVFRAVLEFIYTNCVTLSNHTVIEVLAAAVEYGLDELRKLCERFI 111
BTB_POZ_BACH2 cd18278
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-179 4.40e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349587 [Multi-domain]  Cd Length: 124  Bit Score: 60.73  E-value: 4.40e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHpplgggvggqdglgapkdqqqqqqpqqqp 94
Cdd:cd18278   14 HCTNILLCLNDQRKQDILCDVTLIVEGKEFRAHRAVLAACSEYFLQALVGQ----------------------------- 64

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  95 pqqqqpppqeepgtpssSPDDKLLTSPRAInnlvlqgcSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKL 174
Cdd:cd18278   65 -----------------TENDLVVSLPEEV--------TARGFGPLLQFAYTAKLLLSRENIQEVIRCAEFLRMHNLEDS 119


                 ....*
gi 569003631 175 CVQFL 179
Cdd:cd18278  120 CFRFL 124
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
305-447 8.91e-11

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 62.87  E-value: 8.91e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 305 MPFRqhcRQSLASRIRSNKKmLLLVGGlppgpdrlpsnlvQYYDDEKKTWKILTIMPYNSAHHCVVEVENFLFVLGGEDQ 384
Cdd:COG3055  155 LPTP---RDHLAAAVLPDGK-ILVIGG-------------RNGSGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGGESG 217

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 569003631 385 WNPNgkhstnfVSRYDPRFNSWIQLPPMQERRASFYACRLDKHLYVIGGRNETG----YLSSVECYN 447
Cdd:COG3055  218 FSDE-------VEAYDPATNTWTALGELPTPRHGHAAVLTDGKVYVIGGETKPGvrtpLVTSAEVYD 277
BTB_POZ_BACH1 cd18277
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-179 1.03e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349586 [Multi-domain]  Cd Length: 120  Bit Score: 59.31  E-value: 1.03e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHpplgggvggqdglgapkdqqqqqqpqqqp 94
Cdd:cd18277   10 HSTNVLLSLNDQRKKDVLCDVTILVEGQRFRAHRSVLAACSSYFHSRIVGQ----------------------------- 60

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  95 pqqqqpppqeepgtpssSPDDKLLTSPRAInnlvlqgcSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKL 174
Cdd:cd18277   61 -----------------ADAELNITLPEEV--------TVKGFEPLIQFAYTAKLILSKDNVDEVCKCVEFLSVHNIEES 115


                 ....*
gi 569003631 175 CVQFL 179
Cdd:cd18277  116 CFQFL 120
BTB_POZ_ZBTB24_ZNF450 cd18212
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-63 1.78e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349521 [Multi-domain]  Cd Length: 118  Bit Score: 58.65  E-value: 1.78e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 569003631  14 SHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFS 63
Cdd:cd18212    5 THKDTVLTNFEEQRKKDFLCDITLIVENVQFRAHKALLAASSEYFSMMFA 54
BTB_POZ_ZBTB11 cd18202
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-65 1.83e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349511 [Multi-domain]  Cd Length: 118  Bit Score: 58.71  E-value: 1.83e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 569003631  15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLF------SSH 65
Cdd:cd18202    2 HGQTVLDQLNQQRLNNQFCDVTLLIEGEEYKAHKSVLAANSEYFRELFiekgavSSH 58
BTB_POZ_ZBTB38_CIBZ cd18223
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-65 2.43e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349532 [Multi-domain]  Cd Length: 114  Bit Score: 58.26  E-value: 2.43e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 569003631  15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSH 65
Cdd:cd18223    1 HSDTVLSCLNEQRIQGILCDVTIVVEDTKFKAHKNVLAASSLYFKNAFSSQ 51
BACK_KLHL12 cd18452
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also ...
 195-306 2.66e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also termed CUL3-interacting protein 1 (C3IP1), or DKIR, is a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport.


Pssm-ID: 350527 [Multi-domain]  Cd Length: 136  Bit Score: 58.56  E-value: 2.66e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 195 AALHGLEETKKLANKYLV---------EDVLLLNFEEMRALLDSLPPPVESELALFQMSVLWLEHDRETRMQYAPDLMKR 265
Cdd:cd18452   13 AETHNCVDLMQAAEVFSQkhfpevvqhEEFMLLSQEEVEKLIKSDEIQVDSEEPVFEAVLNWVKHDKEEREDYLPELLQY 92

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 569003631 266 LRFALIPAPELVERVQSVDFMRTDPVCQKLLLDAMNYHLMP 306
Cdd:cd18452   93 VRLPLLSPRYITDVVDAEPLIRCSLECRDLVDEAKKFHLRP 133
BTB_POZ_ZBTB4 cd18195
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-81 3.68e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4); ZBTB4, also called KAISO-like zinc finger protein 1 (KAISO-L1), is a transcriptional repressor with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. ZBTB4 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349504 [Multi-domain]  Cd Length: 124  Bit Score: 57.98  E-value: 3.68e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 569003631  15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHPPLGGGVGGQDGLGAP 81
Cdd:cd18195    1 HAGALLLQLNEQRLRGLFCDVTLIAGDTKFRAHRSVLAASSPYFRELLSSPLPLGAAAVAAAPGATQ 67
BTB_POZ_KLHL40-like cd18269
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-187 5.89e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349578 [Multi-domain]  Cd Length: 133  Bit Score: 57.42  E-value: 5.89e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  19 LLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSShpplgggvggqdglgapkdqqqqqqpqqqppqqq 98
Cdd:cd18269   14 LQDGLKDLLDENKFVDCVLKIGDKEFPCHRLVLAACSPYFRAMFLS---------------------------------- 59

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  99 qpppqeepgtpSSSPDDKlltspraiNNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQF 178
Cdd:cd18269   60 -----------DLEESKK--------KEVVLEDVDPDVMGMILKYLYTSEIDLNDQNVQDIFALASRFQIPSIFTVCVSY 120


                 ....*....
gi 569003631 179 LNDQISVQN 187
Cdd:cd18269  121 LQKRLSLSN 129
BTB_POZ_BTBD14B_NAC1 cd18290
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-67 5.98e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349599 [Multi-domain]  Cd Length: 123  Bit Score: 57.35  E-value: 5.98e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 569003631  13 PSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHPP 67
Cdd:cd18290    8 PNFGNSILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNSSRS 62
PLN02153 PLN02153
epithiospecifier protein
 361-613 7.77e-10

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 60.77  E-value: 7.77e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 361 PYNSAHHCVVEVENFLFVLGGEdqWNPNgKHSTNFVSRYDPRFNSWIQLPPMQER-RASFYACRL---DKHLYVIGGRNE 436
Cdd:PLN02153  20 PGPRCSHGIAVVGDKLYSFGGE--LKPN-EHIDKDLYVFDFNTHTWSIAPANGDVpRISCLGVRMvavGTKLYIFGGRDE 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 437 TGYLSSVECYNLDTNEWRYVSSL-----PQPLAAHAGAVHNGKIYISGGVHNGEYvpwlycydpvmdvwarkqdMNTKRA 511
Cdd:PLN02153  97 KREFSDFYSYDTVKNEWTFLTKLdeeggPEARTFHSMASDENHVYVFGGVSKGGL-------------------MKTPER 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 512 IHTlavmndrlyaiggnhlkgfshldvmlVECYDPKGDQWNILQTP--ILEGRSGPGCAVLDDSIYLVGGYSWSM----- 584
Cdd:PLN02153 158 FRT--------------------------IEAYNIADGKWVQLPDPgeNFEKRGGAGFAVVQGKIWVVYGFATSIlpggk 211

                        250       260       270
                 ....*....|....*....|....*....|
gi 569003631 585 GAYKSSTICYC-PEKGTWTELEGDVAEPLA 613
Cdd:PLN02153 212 SDYESNAVQFFdPASGKWTEVETTGAKPSA 241
BTB_POZ_KLHL2_Mayven cd18338
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 12-183 8.05e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349647 [Multi-domain]  Cd Length: 121  Bit Score: 57.00  E-value: 8.05e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  12 DPSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHpplgggvggqdglgapkdqqqqqqpq 91
Cdd:cd18338    1 NPRHMKKAFKVMNELRSQNLLCDVTIVAEDVEIAAHRVVLAACSPYFHAMFTGE-------------------------- 54

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  92 qqppqqqqpppqeepgtpssspddklLTSPRAiNNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQV 171
Cdd:cd18338   55 --------------------------MSESRA-KRVRIKEVDGWTLKMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDV 107

                        170
                 ....*....|..
gi 569003631 172 TKLCVQFLNDQI 183
Cdd:cd18338  108 KKTCCEFLESQL 119
BTB_POZ_KLHL41_KBTBD10 cd18341
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-187 9.97e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349650 [Multi-domain]  Cd Length: 133  Bit Score: 56.78  E-value: 9.97e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  19 LLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHpplgggvggqdglgapkdqqqqqqpqqqppqqq 98
Cdd:cd18341   14 LQDGLKELLDENKFVDCTLKAGDKSLPCHRLILAACSPYFREYFLSE--------------------------------- 60

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  99 qppPQEEPGtpssspddklltspraiNNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQF 178
Cdd:cd18341   61 ---ESEEKK-----------------KEVVLDNVDPNIMDMILKYLYSAEIDLNDGNVQDIFALASRFQIPSVFTVCVTY 120


                 ....*....
gi 569003631 179 LNDQISVQN 187
Cdd:cd18341  121 LQKRLSPAN 129
BTB2_POZ_KLHL33 cd18263
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 20-64 1.03e-09

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349572 [Multi-domain]  Cd Length: 118  Bit Score: 56.36  E-value: 1.03e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 569003631  20 LHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSS 64
Cdd:cd18263    1 LQSIEGLWEKGVGCDVQLEADGSIFRVHRVILAAGSDYFRAMFTS 45
BTB_POZ_ZBTB28_BCL6B cd18332
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-179 1.10e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349641 [Multi-domain]  Cd Length: 114  Bit Score: 56.40  E-value: 1.10e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSshpplgggvggqdglgapkdqqqqqqpqqqp 94
Cdd:cd18332    2 HSSDVLLNLNELRKRDILTDVTLLVGGTPLRAHKAVLIACSGFFYSIFS------------------------------- 50

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  95 pqqqqpppqEEPGTPSSSpddklLTSPrainnlvlQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKL 174
Cdd:cd18332   51 ---------GRVGEGVSV-----LTLP--------SGLEARGFQLLLDFMYTSRLPLTPRTVPAVLAAATYLQMEHVVET 108


                 ....*
gi 569003631 175 CVQFL 179
Cdd:cd18332  109 CRRFI 113
BTB_POZ_BAB-like cd18315
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 32-168 1.34e-09

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349624 [Multi-domain]  Cd Length: 85  Bit Score: 55.25  E-value: 1.34e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  32 FCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHPplgggvggqdglgapkdqqqqqqpqqqppqqqqpppqeepgtPSS 111
Cdd:cd18315    1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKETP------------------------------------------PDE 38

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 569003631 112 SPDdklltsprainnLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHI 168
Cdd:cd18315   39 HPV------------IILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAELLQI 83
BACK_KLHL2_like cd18445
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This ...
 195-281 1.43e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This subfamily includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. Both KLHL2 and KLHL3 function as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins.


Pssm-ID: 350520 [Multi-domain]  Cd Length: 114  Bit Score: 56.09  E-value: 1.43e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 195 AALHGLEETKKLANKYLV---------EDVLLLNFEEMRALLDSLPPPVESELALFQMSVLWLEHDRETRMQYAPDLMKR 265
Cdd:cd18445   13 ADLHSCTDLLKYAQTYTEqhfsevvkgEEFLLLSKEQVCELISSDDLTVPSEEKVFEAVMSWVNHDPENRKEHLAELLEH 92

                         90
                 ....*....|....*.
gi 569003631 266 LRFALIPAPELVERVQ 281
Cdd:cd18445   93 VRLPLLSPEYLVQRVE 108
BTB_POZ_KLHL38 cd18268
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-187 1.45e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349577 [Multi-domain]  Cd Length: 129  Bit Score: 56.33  E-value: 1.45e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  11 FDPSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSShpplgggvggqdglgapkdqqqqqqp 90
Cdd:cd18268    2 KDQDLSSELLRQLNSLRQERILTDVILCTGDKEIPCHRNVLASSSPYFRAMFCN-------------------------- 55

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  91 qqqppqqqqpppqeepgtpssspDDKLLTSPRainnLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQ 170
Cdd:cd18268   56 -----------------------NFRESSQAK----VDLKGIDSDVLDQIVDYVYTGEILITRDNVLPLMEAASMLQYPK 108

                        170
                 ....*....|....*..
gi 569003631 171 VTKLCVQFLNDQISVQN 187
Cdd:cd18268  109 LFEACSLYLQDQLTPEN 125
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-62 1.88e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 55.71  E-value: 1.88e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 569003631  15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLF 62
Cdd:cd18287    5 HVHFLSEDIGALFLNEEYSDVTFVVEEKRFPAHRVILAARSEYFRALL 52
BTB_POZ_ZBTB19_PATZ1 cd18207
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-186 3.88e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349516 [Multi-domain]  Cd Length: 128  Bit Score: 54.97  E-value: 3.88e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  15 HSDNLLHGLNLlWRKQ--LFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHpplgggvggqdglgapkdqqqqqqpqq 92
Cdd:cd18207    9 HSADMLHNLNQ-QRKSggRFCDVLLRVGEESFPAHRAVLAACSEYFESVFSAQ--------------------------- 60

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  93 qppqqqqpppQEEPGTPssspddklltspraiNNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVT 172
Cdd:cd18207   61 ----------EGDGGTP---------------RELEMHTISSKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVI 115

                        170
                 ....*....|....
gi 569003631 173 KLCVQFLNdQISVQ 186
Cdd:cd18207  116 DICQEVIK-QSNVQ 128
BTB_POZ_ZBTB48_TZAP_KR3 cd18232
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-178 5.66e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349541 [Multi-domain]  Cd Length: 108  Bit Score: 53.99  E-value: 5.66e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFsshpplgggvggqdglgapkdqqqqqqpqqqp 94
Cdd:cd18232    1 HSVKVLQALNKQREEGQYCDATLDVGGRVFKAHWSVLACCSHFFQSLY-------------------------------- 48

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  95 pqqqqpppqeepGTPSSSpddklltsprainNLVL-QGCSSIgLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTK 173
Cdd:cd18232   49 ------------GDGTSG-------------SVVLpESFAEV-FGLLLDFFYTGELALTRENRDRVLLAAKELRVPEAVE 102


                 ....*
gi 569003631 174 LCVQF 178
Cdd:cd18232  103 LCQRF 107
BTB_POZ_KLHL40_KBTBD5 cd18340
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-187 6.69e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349649 [Multi-domain]  Cd Length: 134  Bit Score: 54.46  E-value: 6.69e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  19 LLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHpplgggvggqdglgapkdqqqqqqpqqqppqqq 98
Cdd:cd18340   14 LQDGLKDLLDHNKFVDCVLKIKEKEFPCHRLVLAACSPYFRAMFLSD--------------------------------- 60

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  99 qpppqeepgtpssspddkllTSPRAINNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQF 178
Cdd:cd18340   61 --------------------LEESKKREIVLEDVDPDVMGKILHYIYTSEIEITEQNVQDIFAAANMFQIPSIFTVCVSF 120


                 ....*....
gi 569003631 179 LNDQISVQN 187
Cdd:cd18340  121 LQKRLCLSN 129
BTB_POZ_ZBTB10 cd18201
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-184 6.97e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349510 [Multi-domain]  Cd Length: 122  Bit Score: 54.19  E-value: 6.97e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  14 SHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSShpplgggvggqdglgapkdqqqqqqpqqq 93
Cdd:cd18201    3 SYCYQLLQELNEQRKKGILCDVNIVVSGKVFRAHKNILVAGSRFFKTLYCF----------------------------- 53

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  94 ppqqqqpppqeepgTPSSSPDDKLLTSpraINNLVLQGCSSIglrlvLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTK 173
Cdd:cd18201   54 --------------TNKESCDQTTVTH---LDVVAVQGFSVI-----LDFMYSGNLVLTSQNAIEVMSVASYLQMTEVVQ 111

                        170
                 ....*....|.
gi 569003631 174 LCVQFLNDQIS 184
Cdd:cd18201  112 SCRNFIKDALN 122
BTB_POZ_BACH cd18955
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 33-179 7.71e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349736 [Multi-domain]  Cd Length: 94  Bit Score: 53.24  E-value: 7.71e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  33 CDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHpplgggvggqdglgapkdqqqqqqpqqqppqqqqpppqeepgtpssS 112
Cdd:cd18955    2 CDVTIVVEDQRFRAHRAVLAACSDYFLSRVVGQ----------------------------------------------T 35

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 569003631 113 PDDKLLTSPRAInnlvlqgcSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFL 179
Cdd:cd18955   36 DGDLVITLPEEV--------TVKGFEPLLQFAYTAKLLLSKENVLEVCRCAEFLGVHNIEKACFDFL 94
BTB_POZ_KLHL3 cd18339
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 12-183 8.28e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349648 [Multi-domain]  Cd Length: 121  Bit Score: 53.96  E-value: 8.28e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  12 DPSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSshpplgggvggqdglgapkdqqqqqqpq 91
Cdd:cd18339    1 NPAHMKKAFKVMNELRSKQLLCDVTIVAEDVEIEAHRVVLAACSPYFCAMFT---------------------------- 52

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  92 qqppqqqqpppqeepGTPSSSPDDKLltsprAINNLVLQgcssiGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQV 171
Cdd:cd18339   53 ---------------GDMSESKAKKI-----EIKDVDGQ-----TLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDV 107

                        170
                 ....*....|..
gi 569003631 172 TKLCVQFLNDQI 183
Cdd:cd18339  108 RQNCCDFLQSQL 119
BTB_POZ_KLHL19_KEAP1 cd18248
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-183 9.78e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349557 [Multi-domain]  Cd Length: 124  Bit Score: 53.92  E-value: 9.78e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  14 SHSDNLLHGLNLLWRKQLFCDVTLTAQGQ----QFHCHKAVLASCSQYFRSLFSShpplgggvggqdglgapkdqqqqqq 89
Cdd:cd18248    3 DHTKEAFQIMNELRLSQQLCDVTLKVKYQdpkeEFMAHKVVLASSSPYFKAMFTS------------------------- 57

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  90 pqqqppqqqqppPQEEpgtpssspddklltspRAINNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIP 169
Cdd:cd18248   58 ------------GLRE----------------CGMEVVPIEGVHPCVMSRLIEFAYTASISVGEKCVLHVLPGAVMYQMD 109

                        170
                 ....*....|....
gi 569003631 170 QVTKLCVQFLNDQI 183
Cdd:cd18248  110 SVVKACCDFLEQQL 123
PLN02193 PLN02193
nitrile-specifier protein
 367-579 1.16e-08

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 57.66  E-value: 1.16e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 367 HCVVEVENFLFVLGGEDQWN-PNGKHSTNFvsryDPRFNSWIQLPPMQE-RRASFYACRL---DKHLYVIGGRNETGYLS 441
Cdd:PLN02193 169 HGIAQVGNKIYSFGGEFTPNqPIDKHLYVF----DLETRTWSISPATGDvPHLSCLGVRMvsiGSTLYVFGGRDASRQYN 244

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 442 SVECYNLDTNEWRYVSSL---PQPLAAHAGAVHNGKIYISGGVHNGEYVPWLYCYDPVMDVW---ARKQDMNTKRAIHTL 515
Cdd:PLN02193 245 GFYSFDTTTNEWKLLTPVeegPTPRSFHSMAADEENVYVFGGVSATARLKTLDSYNIVDKKWfhcSTPGDSFSIRGGAGL 324

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 569003631 516 AVMNDRLYAIggnhlKGFSHLDVMLVECYDPKGDQWNILQT----PilEGRSGPGCAVLDDSIYLVGG 579
Cdd:PLN02193 325 EVVQGKVWVV-----YGFNGCEVDDVHYYDPVQDKWTQVETfgvrP--SERSVFASAAVGKHIVIFGG 385
PHA02713 PHA02713
hypothetical protein; Provisional
 435-579 1.47e-08

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 57.71  E-value: 1.47e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 435 NETGYLSSVEC---YNLDTNEWRYVSSLPQPLAAHAGAVHNGKIYISGGVH-NGEYVPWLYCYDPVMDVWARKQDMNTKR 510
Cdd:PHA02713 263 HDTKYNVCNPCilvYNINTMEYSVISTIPNHIINYASAIVDNEIIIAGGYNfNNPSLNKVYKINIENKIHVELPPMIKNR 342

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 511 AIHTLAVMNDRLYAIGGNHLKGFSHldvmLVECYDPKGDQWNIL-QTPIleGRSGPGCAVLDDSIYLVGG 579
Cdd:PHA02713 343 CRFSLAVIDDTIYAIGGQNGTNVER----TIECYTMGDDKWKMLpDMPI--ALSSYGMCVLDQYIYIIGG 406
BTB_POZ_BTBD18 cd18293
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 26-177 1.50e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349602 [Multi-domain]  Cd Length: 120  Bit Score: 53.26  E-value: 1.50e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  26 LWRKQ---LFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHPPlgggvggqdglgapkdqqqqqqpqqqppqqqqppp 102
Cdd:cd18293    6 LHRQQnsgVFCDVLLQAEGESVPAHCCVLSACSPYLTERLSSEPP----------------------------------- 50

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 569003631 103 qeepgtPSSSpddKLLtsprainnLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQ 177
Cdd:cd18293   51 ------PAGQ---KVV--------LELQGLKAHTLLKLVDFLYTSELEVSSEEAQDVLAAARRLQISELESLCLE 108
BTB_POZ_BTBD14A_NAC2 cd18289
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-63 1.55e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349598 [Multi-domain]  Cd Length: 131  Bit Score: 53.50  E-value: 1.55e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 569003631  13 PSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFS 63
Cdd:cd18289   10 PNFGNTVLGCLNEQRLMGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFS 60
BTB_POZ_ZBTB33_KAISO cd18219
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 12-63 1.65e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kaiso; Kaiso, also called zinc finger and BTB domain-containing protein 33 (ZBTB33), is a DNA methylation-dependent transcriptional repressor that binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3'. It also binds to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349528 [Multi-domain]  Cd Length: 106  Bit Score: 52.53  E-value: 1.65e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 569003631  12 DPSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFS 63
Cdd:cd18219    1 DTQYSGSLLKSLNEQRGHGLFCDVTVIVEDRKFRAHKNILSASSTYFHQLFS 52
BACK_KLHL9_13 cd18449
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 ...
 183-269 1.89e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 and KLHL13 (also termed BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.


Pssm-ID: 350524 [Multi-domain]  Cd Length: 95  Bit Score: 52.04  E-value: 1.89e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 183 ISVQNYKQVCKIAALHGLEETKKLANKYL---------VEDVLLLNFEEMRALLDSLPPPVESELALFQMSVLWLEHDrE 253
Cdd:cd18449    1 VSLENCVEIGRIANTYHLTEVDKYVNDFIlknfpallsTGDFVKLPFERLAFVLSSNSLKGCTELELFKAACRWLRHE-D 79

                         90
                 ....*....|....*.
gi 569003631 254 TRMQYAPDLMKRLRFA 269
Cdd:cd18449   80 DRMQFAAKLMENIRFP 95
BTB_POZ_ZBTB6 cd18197
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-62 3.98e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 6 (ZBTB6); ZBTB6, also called zinc finger protein 482 (ZNF482) or zinc finger protein with interaction domain, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349506 [Multi-domain]  Cd Length: 116  Bit Score: 51.79  E-value: 3.98e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 569003631  14 SHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLF 62
Cdd:cd18197    7 QQGDAVLQKMNLLRQQNLFCDVSIYINDTEFHGHKVILAACSTFMRDQF 55
BTB_POZ_ZBTB12 cd18203
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-66 4.46e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 12 (ZBTB12); ZBTB12, also called protein G10, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349512 [Multi-domain]  Cd Length: 122  Bit Score: 51.80  E-value: 4.46e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 569003631  13 PSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHP 66
Cdd:cd18203    6 PGHEAATLRNMNQLRSEERFCDVTIVADSLKFRGHKVVLAACSPFLRDQFLLNP 59
BTB2_POZ_ABTB1_BPOZ1 cd18296
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 30-175 4.56e-08

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349605 [Multi-domain]  Cd Length: 121  Bit Score: 51.91  E-value: 4.56e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  30 QLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHpplgggvggqdglgapkdqqqqqqpqqqppqqqqppPQEEPGTP 109
Cdd:cd18296   15 LSFPDVCFQVEGHRFPCHKAFFCGRSDYFKALLRDH------------------------------------FAESEENN 58

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 569003631 110 SSSPddklltsprainNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLC 175
Cdd:cd18296   59 GSIP------------VVTLHDVSPEVFAIVLYYIYTDDTDLPPENAYDVLYVADMYLLPGLKRLC 112
BTB_POZ_ZBTB49 cd18233
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-179 5.31e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49); ZBTB49, also called zinc finger protein 509 (ZNF509), is a transcription factor that inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. There are four ZNF509 isoforms generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). ZBTB49 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349542 [Multi-domain]  Cd Length: 112  Bit Score: 51.43  E-value: 5.31e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSShpplgggvggqdglgapkdqqqqqqpqqqp 94
Cdd:cd18233    1 HSCHLLQQLHEQRIQGLLCDCMLVVKGVCFKAHKNVLAAFSQYFRSLFQN------------------------------ 50

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  95 pqqqqpppqeepgTPSSSPDdklltspraINNLVLQGCSSIGlrLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKL 174
Cdd:cd18233   51 -------------SSSQKND---------VFHLDIKNVGGIG--QILDFMYTSHLDLNQDNVQVMLDIAQCLQVQNVLNM 106


                 ....*
gi 569003631 175 CVQFL 179
Cdd:cd18233  107 CYTFL 111
BTB_POZ_KBTBD12 cd18276
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-63 7.08e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349585 [Multi-domain]  Cd Length: 127  Bit Score: 51.34  E-value: 7.08e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 569003631  15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFS 63
Cdd:cd18276    4 HSLTLLDQLNRMKELAELTDVVLVAEGEKFPCHRLVLAAFSPYFKAMFT 52
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 462-507 1.91e-07

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 47.61  E-value: 1.91e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 569003631  462 PLAAHAGAVHNGKIYISGGVHNGEYVPWLYCYDPVMDVWARKQDMN 507
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
BTB_POZ_ZBTB21_ZNF295 cd18209
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-64 2.00e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21); ZBTB21, also called zinc finger protein 295 (ZNF295), is a transcription repressor that acts in a selective manner on different promoters. It may be involved in the bi-directional control of gene expression in concert with another transcription factor ZFP161. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349518 [Multi-domain]  Cd Length: 112  Bit Score: 49.87  E-value: 2.00e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 569003631  15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSS 64
Cdd:cd18209    1 HAISLLSALNEERLKGQLCDVLLIVGDQKFRAHKNVLAASSEYFQSLFTE 50
BTB_POZ_ZBTB1 cd18192
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-65 2.07e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 1 (ZBTB1); ZBTB1 acts as a transcriptional repressor that represses cAMP-responsive element (CRE)-mediated transcriptional activation. It also has a role in translesion DNA synthesis, and is essential for lymphocyte development. ZBTB1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349501 [Multi-domain]  Cd Length: 114  Bit Score: 49.82  E-value: 2.07e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 569003631  13 PSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSH 65
Cdd:cd18192    2 PSHSSYVLQQLNNQREWGFLCDCCIAIDDIYFQAHKAVLAACSSYFRMMFINH 54
BTB_POZ_KLHL6 cd18236
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-187 2.31e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349545 [Multi-domain]  Cd Length: 129  Bit Score: 50.23  E-value: 2.31e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  19 LLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHpplgggvggqdglgapkdqqqqqqpqqqppqqq 98
Cdd:cd18236   11 LQNGLENLRLENSLTDVILCVDSQEFSCHRVVLAAASNYFRAMFCND--------------------------------- 57

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  99 QPPPQEEpgtpssspddklltsprainNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQF 178
Cdd:cd18236   58 LKEKYEE--------------------KIIIKGVDAETMQILLDYTYTSKVLITKQNVQRVLEAASLFQFLRMVDACASF 117


                 ....*....
gi 569003631 179 LNDQISVQN 187
Cdd:cd18236  118 LTEALHPEN 126
BTB_POZ_ZBTB3 cd18323
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-175 2.87e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3); ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB3 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349632 [Multi-domain]  Cd Length: 128  Bit Score: 49.83  E-value: 2.87e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  13 PSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHPPlgggvggqdglgaPKDQQQQqqpqq 92
Cdd:cd18323    4 PDHSRHLLQSLREQRHQGFLCDCTVLVGSTQFLAHRAVLASCSPFFHMFYKEQLD-------------KRDLVCI----- 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  93 qppqqqqpppqeepgtpssspDDKLLTSPrainnlvlqgcssiGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVT 172
Cdd:cd18323   66 ---------------------NNEIVTAP--------------AFSLLLEFMYEGRLSFNDTPVEDVLAAASYLHMNDIV 110


                 ...
gi 569003631 173 KLC 175
Cdd:cd18323  111 KVC 113
BTB_POZ_ZBTB18_2-like cd18325
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-182 3.13e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18.2 and similar proteins; This subfamily is composed of Xenopus laevis zinc finger and BTB domain-containing protein 18.2, encoded by the znf238.2.L gene, and similar proteins. Many proteins in this group are annotated as zinc finger and BTB domain-containing protein 42 (ZBTB42). However, characterized mammalian ZBTB42 does not belong to this subfamily. ZBTB18.2, like ZBTB18, functions as a transcriptional repressor that plays a role in various developmental processes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349634 [Multi-domain]  Cd Length: 128  Bit Score: 49.65  E-value: 3.13e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  13 PSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSshpplgggvggqdglgapkdqqqqqqpqq 92
Cdd:cd18325    4 PDHSRQLLQCLSQQRHQGFLCDCTVLVGEAQFRAHRAVLASCSMYFHLFYR----------------------------- 54

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  93 qppqqqqpppqeepgtpssspdDKLltSPRAINNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVT 172
Cdd:cd18325   55 ----------------------DQL--DKRDIVHLNSDIVTAPAFSLLLEFMYEGKLEFSSLPVEDVLAAASYLHMYDIV 110

                        170
                 ....*....|
gi 569003631 173 KLCVQFLNDQ 182
Cdd:cd18325  111 KVCKGKLKDK 120
BTB_POZ_ZBTB39 cd18224
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-64 3.23e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 39 (ZBTB39); ZBTB39 may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349533 [Multi-domain]  Cd Length: 123  Bit Score: 49.45  E-value: 3.23e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 569003631  15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSS 64
Cdd:cd18224    9 HPNNLLKELNKCRLSETMCDVTIVVGNRSFAAHKAVLACAAGYFQKLFLS 58
BTB_POZ_ZBTB35_ZNF131 cd18221
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-62 3.35e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349530 [Multi-domain]  Cd Length: 113  Bit Score: 49.23  E-value: 3.35e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 569003631  15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLF 62
Cdd:cd18221    1 HYKVMLDRLNEQRELDQFTDITLIVDGHQFKAHKAVLAACSQFFYKFF 48
PHA02790 PHA02790
Kelch-like protein; Provisional
 366-606 3.75e-07

Kelch-like protein; Provisional


Pssm-ID: 165153 [Multi-domain]  Cd Length: 480  Bit Score: 53.12  E-value: 3.75e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 366 HHCV-VEVENFLFVLGGedqWNPNGKHstNFVSRYDPRFNSWIQLPPMQERRASFYACRLDKHLYVIGGRNETgylSSVE 444
Cdd:PHA02790 263 HMCTsTHVGEVVYLIGG---WMNNEIH--NNAIAVNYISNNWIPIPPMNSPRLYASGVPANNKLYVVGGLPNP---TSVE 334

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 445 CYNLDTNEWRYVSSLPQPLAAHAGAVHNGKIYISGGvHNGEYVPWLYCYdPVMDVWARKQDMNTKRAIHTLAVMNDRLYA 524
Cdd:PHA02790 335 RWFHGDAAWVNMPSLLKPRCNPAVASINNVIYVIGG-HSETDTTTEYLL-PNHDQWQFGPSTYYPHYKSCALVFGRRLFL 412

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 525 IGGNhlkgfshldvmlVECYDPKGDQWNILQTPILEgRSGPGCAVLDDSIYLVGGYswSMGAYKSSTICYCPEKGTWTEL 604
Cdd:PHA02790 413 VGRN------------AEFYCESSNTWTLIDDPIYP-RDNPELIIVDNKLLLIGGF--YRGSYIDTIEVYNNRTYSWNIW 477


                 ..
gi 569003631 605 EG 606
Cdd:PHA02790 478 DG 479
Kelch_4 pfam13418
Galactose oxidase, central domain;
415-461 4.24e-07

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 46.84  E-value: 4.24e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 569003631  415 RRASFYACRLDKH-LYVIGGRNETG-YLSSVECYNLDTNEWRYVSSLPQ 461
Cdd:pfam13418   1 PRAYHTSTSIPDDtIYLFGGEGEDGtLLSDLWVFDLSTNEWTRLGSLPS 49
BTB_POZ_ZBTB37 cd18222
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-63 4.27e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37); ZBTB37 may be involved in transcriptional regulation. It is differentially expressed in aryl hydrocarbon receptor (AhR)-KO mice compared with WT mice, and may potentially contribute to the aging phenotype of AhR-KO mice. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349531 [Multi-domain]  Cd Length: 123  Bit Score: 49.27  E-value: 4.27e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 569003631  13 PSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFS 63
Cdd:cd18222    6 PDFSNSVLSHLNQLRMQGRLCDIVVNVQGQSFRAHKVVLAASSPYFRDHMS 56
BTB_POZ_ZBTB27-like cd18215
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-62 4.80e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349524 [Multi-domain]  Cd Length: 113  Bit Score: 48.72  E-value: 4.80e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 569003631  15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLF 62
Cdd:cd18215    2 HASDVLLNLNRLRSRDILTDVVLVVGREQFRAHKTVLMACSGLFYSIF 49
BTB_POZ_ZBTB8A_BOZF1 cd18329
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-63 5.01e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349638 [Multi-domain]  Cd Length: 116  Bit Score: 48.67  E-value: 5.01e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 569003631  14 SHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFS 63
Cdd:cd18329    3 SHQSRLLQQLDEQRKQELFCDCSILVEGQVFKAHRNVLFASSGYFKMLLS 52
PRK14131 PRK14131
N-acetylneuraminate epimerase;
424-579 5.56e-07

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 52.32  E-value: 5.56e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 424 LDKHLYVIGG---RNETG---YLSSVECYNLDTNEWRYVSSL-PQPLAAHAGAV-HNGKIYISGGVH----NGEYVpwly 491
Cdd:PRK14131  83 IDGKLYVFGGigkTNSEGspqVFDDVYKYDPKTNSWQKLDTRsPVGLAGHVAVSlHNGKAYITGGVNknifDGYFE---- 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 492 cydpvmDVWARKQDMNTKRAIhTLAVMNDRLYAIggnhlkgFSHLDVMLvecYDPKGDQW-NILQTPILeGRSGPGCAVL 570
Cdd:PRK14131 159 ------DLAAAGKDKTPKDKI-NDAYFDKKPEDY-------FFNKEVLS---YDPSTNQWkNAGESPFL-GTAGSAVVIK 220


                 ....*....
gi 569003631 571 DDSIYLVGG 579
Cdd:PRK14131 221 GNKLWLING 229
BTB_POZ_KBTBD3_BKLHD3 cd18271
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-191 5.80e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349580 [Multi-domain]  Cd Length: 130  Bit Score: 49.06  E-value: 5.80e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  14 SHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHpplgggvggqdglgapkdqqqqqqpqqq 93
Cdd:cd18271    6 CHGQQILSVLQNFREQNAFFDFNIIVKDETIPCHRCVLAACSDFFRAMFEVN---------------------------- 57

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  94 ppqqqqpppqeepgtpSSSPDDKLLTspraINNLvlqgcSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTK 173
Cdd:cd18271   58 ----------------MKERDDGSVT----ISNL-----SPKAVKAFLDYAYTGKAEITDDNVEMFFQMSSFLQVSLLSK 112

                        170
                 ....*....|....*...
gi 569003631 174 LCVQFLNDQISVQNYKQV 191
Cdd:cd18271  113 ACSDFLIKSIDLTNCLQL 130
BACK_KLHL18 cd18457
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as ...
 207-280 9.40e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A.


Pssm-ID: 350532 [Multi-domain]  Cd Length: 107  Bit Score: 47.69  E-value: 9.40e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 207 ANKYL---------VEDVLLLNFEEMRALL--DSLPppVESELALFQMSVLWLEHDRETRMQYAPDLMKRLRFALIPAPE 275
Cdd:cd18457   25 ANKYIqqhfievskSEEFLALSKEEVLEILsrDELN--VKSEEQVFEAALAWVKYDRENREEYLPELLSKVRLPLLRPQF 102


                 ....*
gi 569003631 276 LVERV 280
Cdd:cd18457  103 LTDRV 107
BTB_POZ_KBTBD4 cd18272
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-191 1.08e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349581 [Multi-domain]  Cd Length: 140  Bit Score: 48.35  E-value: 1.08e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631   8 TSTF-DPSHSDNLLHG-LNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHpplgggvggqdglgapkdqq 85
Cdd:cd18272    6 SYTFtDRSHSSRVAQSiMDLCLEDGLFADVTISVEGKEFQLHRLVLSAQSCFFRSMFTSN-------------------- 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  86 qqqqpqqqppqqqqpppqeepgtpssspddklLTSPRAiNNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKI 165
Cdd:cd18272   66 --------------------------------LKEARN-RVIELKDVSESVFQLLVDYIYHGTVKLRVEELQETYEVADM 112

                        170       180
                 ....*....|....*....|....*.
gi 569003631 166 LHIPQVTKLCVQFLNDQISVQNYKQV 191
Cdd:cd18272  113 YQLTALFEECSRFLARTVQVRNCLQV 138
BTB_POZ_KLHL29_KBTBD9 cd18258
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-187 1.19e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349567 [Multi-domain]  Cd Length: 125  Bit Score: 48.05  E-value: 1.19e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  19 LLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSShpplgggvggqdglgAPKDqqqqqqpqqqppqqq 98
Cdd:cd18258    4 MLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKR---------------SSRD--------------- 53

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  99 qpppqeepgtpsSSPDDKLltsprainNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQF 178
Cdd:cd18258   54 ------------SGGGEKL--------ELTMSNINADVLELLLEFVYTGSLIIDSANAKTLLEAANKFQFHTFCKVCVSF 113


                 ....*....
gi 569003631 179 LNDQISVQN 187
Cdd:cd18258  114 LEKQLTASN 122
BTB_POZ_ZBTB18_RP58 cd18324
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-186 1.27e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349633 [Multi-domain]  Cd Length: 147  Bit Score: 48.50  E-value: 1.27e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  13 PSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFsshpplgggvggqdglgapKDQQqqqqpqq 92
Cdd:cd18324    4 PDHSRHLLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMYFHLFY-------------------KDQL------- 57

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  93 qppqqqqpppqeepgtpssspdDKlltspRAINNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVT 172
Cdd:cd18324   58 ----------------------DK-----RDIVHLNSDIVTAPAFALLLEFMYEGKLQFKDLPIEDVLAAASYLHMYDIV 110

                        170
                 ....*....|....
gi 569003631 173 KLCVQFLNDQISVQ 186
Cdd:cd18324  111 KVCKKKLKEKATTE 124
BTB_POZ_ZBTB29-like cd18216
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-61 1.66e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349525 [Multi-domain]  Cd Length: 118  Bit Score: 47.14  E-value: 1.66e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 569003631  13 PSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSL 61
Cdd:cd18216    1 PSHATQLLLQLNNQRTKGFLCDVIIVVENSLFRAHKNVLAASSGYFKSL 49
Kelch smart00612
Kelch domain;
474-520 1.79e-06

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 44.86  E-value: 1.79e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 569003631   474 KIYISGGVHNGEYVPWLYCYDPVMDVWARKQDMNTKRAIHTLAVMND 520
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BACK_KLHL1_like cd18444
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; ...
 195-277 1.84e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This subfamily contains Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. Members of this subfamily contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels.


Pssm-ID: 350519 [Multi-domain]  Cd Length: 106  Bit Score: 46.94  E-value: 1.84e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 195 AALHGLEETKKLANKYLVE---------DVLLLNFEEMRALLDSLPPPVESELALFQMSVLWLEHDRETRMQYAPDLMKR 265
Cdd:cd18444   14 ADAQGCTDLLKVAHNYTMEhfmeviqnqEFLLLPAEEVAKLLASDDLNVPSEETIFHALLLWVKHDLPERKKHLAKLLAL 93

                         90
                 ....*....|..
gi 569003631 266 LRFALIPaPELV 277
Cdd:cd18444   94 IRLPLLT-PQFL 104
BTB_POZ_ZBTB41 cd18226
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-66 1.95e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41); ZBTB41, also called FRBZ1, may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349535 [Multi-domain]  Cd Length: 114  Bit Score: 47.10  E-value: 1.95e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 569003631  15 HSDNLLHGLNLLWRKQL-FCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHP 66
Cdd:cd18226    4 YNKNLLKYLNDDRQKQSsFCDLVITVEGKEFSAHKVVVAVGSSYFHACLSKNP 56
BTB2_POZ_IBtk cd18302
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 32-187 1.99e-06

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349611 [Multi-domain]  Cd Length: 113  Bit Score: 46.97  E-value: 1.99e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  32 FCDVTLTAQ-GQQFHCHKAVLASCSQYFRSLFSSHpplgggvggqdglgapkdqqqqqqpqqqppqqqqpppqeepGTPS 110
Cdd:cd18302    5 LYDVTIVSEdGKEFPCHKCVLVARLEYFHSMLSSS-----------------------------------------WIEA 43

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 111 SSpdDKLLTSPraINNLVLQgcssiglrLVLEYLYT---ANVTLSLDT--VEEVLSVSKILHIPQVTKLCVQFLNDQISV 185
Cdd:cd18302   44 SS--CSALTMP--IPSDILE--------IILDYLYTdeaSAVKESQNVefLCNVLVIADQLLITRLKEICEVALVELLSL 111


                 ..
gi 569003631 186 QN 187
Cdd:cd18302  112 KN 113
BTB_POZ_KLHL20_KLEIP cd18249
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-63 2.11e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349558 [Multi-domain]  Cd Length: 128  Bit Score: 47.45  E-value: 2.11e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 569003631  15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFS 63
Cdd:cd18249    6 HPRQTLEAINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFT 54
BTB_POZ_roadkill-like cd18345
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-62 2.25e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349654 [Multi-domain]  Cd Length: 121  Bit Score: 47.15  E-value: 2.25e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 569003631  23 LNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLF 62
Cdd:cd18345    9 LGLLFERSAFSDVTLCVGGREFQAHKAILAARSPVFNAMF 48
BTB_POZ_KLHL22 cd18251
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-179 2.38e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349560 [Multi-domain]  Cd Length: 125  Bit Score: 47.12  E-value: 2.38e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  14 SHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSShpplgggvggqdglgapkdqqqqqqpqqq 93
Cdd:cd18251    5 AHSQALLDGLVALRDSGILFDVVLVVEGKPIEAHRILLAASCDYFRGMFAG----------------------------- 55

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  94 ppqQQQPPPQEEpgtpssspddklltsprainnLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTK 173
Cdd:cd18251   56 ---GLREMQQTE---------------------VLIHGVSYNAMCKILDFIYTSELELSLDNVQETLTAACQLQIPEVIG 111


                 ....*.
gi 569003631 174 LCVQFL 179
Cdd:cd18251  112 FCCDFL 117
BTB_POZ_ZBTB3-like cd18194
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-66 2.58e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349503 [Multi-domain]  Cd Length: 128  Bit Score: 47.12  E-value: 2.58e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 569003631  13 PSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHP 66
Cdd:cd18194    4 PEHSRQLLQCLREQRSQGFLCDCTVLVGSAQFPAHRAVLASCSMYFHLFYRDRL 57
BTB_POZ_KLHL18 cd18247
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-64 2.98e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349556 [Multi-domain]  Cd Length: 116  Bit Score: 46.50  E-value: 2.98e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 569003631  23 LNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSS 64
Cdd:cd18247   10 MEEIRRQGKLCDVTLKVGDQKFSAHRIVLAATIPYFHAMFTH 51
Kelch smart00612
Kelch domain;
521-572 3.36e-06

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 44.09  E-value: 3.36e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 569003631   521 RLYAIGGNHlkGFSHLDVmlVECYDPKGDQWNILqTPILEGRSGPGCAVLDD 572
Cdd:smart00612   1 KIYVVGGFD--GGQRLKS--VEVYDPETNKWTPL-PSMPTPRSGHGVAVING 47
BTB2_POZ_LZTR1 cd18309
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 32-67 4.12e-06

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349618 [Multi-domain]  Cd Length: 126  Bit Score: 46.23  E-value: 4.12e-06
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 569003631  32 FCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHPP 67
Cdd:cd18309   20 FCDITLLLDGHPIPAHKAILAARCSYFEAMFRSFMP 55
BTB_POZ_ZBTB34 cd18220
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-59 4.69e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34); ZBTB34 acts as a transcriptional regulator. It downregulates specificity protein (Sp) transcription factors Sp1, Sp3, and Sp4 in pancreatic cancer cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349529 [Multi-domain]  Cd Length: 120  Bit Score: 46.17  E-value: 4.69e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 569003631  11 FD-PSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFR 59
Cdd:cd18220    3 FDvPEYSNTVLSQLNELRLQGKLCDIIVHIQGQPFRAHKAVLAASSPYFR 52
BTB_POZ_ZBTB30_HIC2 cd18334
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-61 4.70e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349643 [Multi-domain]  Cd Length: 120  Bit Score: 46.11  E-value: 4.70e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 569003631  13 PSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSL 61
Cdd:cd18334    2 PNHAKQLLLQLNQQRAKGFLCDVIIVVENALFRAHKNILAASSMYFKSL 50
BTB_POZ_KLHL1-like cd18234
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 33-187 4.77e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349543 [Multi-domain]  Cd Length: 105  Bit Score: 45.43  E-value: 4.77e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  33 CDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHpplgggvggqdglgapkdqqqqqqpqqqppqqQQPPPQEEpgtpsss 112
Cdd:cd18234    2 CDVILIAGDRRIPAHRLVLSAVSDYFAAMFTND--------------------------------VREATEEE------- 42

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 569003631 113 pddklltsprainnLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQN 187
Cdd:cd18234   43 --------------IKLKDVDPDALWTLVQYCYTGRLELKEDNVESLLATACLLQLSEVVEACCGFLMKQLHPSN 103
Kelch_3 pfam13415
Galactose oxidase, central domain;
425-471 5.10e-06

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 43.82  E-value: 5.10e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 569003631  425 DKHLYVIGGRNETG--YLSSVECYNLDTNEWRYVSSLPQPLAAHAGAVH 471
Cdd:pfam13415   1 GDKLYIFGGLGFDGqtRLNDLYVYDLDTNTWTQIGDLPPPRSGHSATYI 49
BTB_POZ_ZBTB29_HIC1 cd18333
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-61 5.26e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1); Hic-1, also called zinc finger and BTB domain-containing protein 29 (ZBTB29), is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. It may act as a tumor suppressor, and is involved in regulatory loops modulating P53-dependent and E2F1-dependent cell survival, growth control, and stress responses. It also regulates intestinal immunity and homeostasis. Hic-1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349642 [Multi-domain]  Cd Length: 121  Bit Score: 46.05  E-value: 5.26e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 569003631  13 PSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSL 61
Cdd:cd18333    2 PSHSRQLLLQLNTQRTKGFLCDVIIVVQNALFRAHKNILAASSVYLKSL 50
BTB_POZ_BTBD17 cd18292
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 16-64 5.77e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349601 [Multi-domain]  Cd Length: 114  Bit Score: 45.74  E-value: 5.77e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 569003631  16 SDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSS 64
Cdd:cd18292    1 SREFLQDIAQLYNNEELSDIVLRVGGKVFHAHRLILAKSSDVFRVMLSN 49
BTB_POZ_ZBTB23_GZF1 cd18211
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-177 6.12e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1); GZF1 is also called GDNF-inducible zinc finger protein 1, zinc finger and BTB domain-containing protein 23 (ZBTB23), or zinc finger protein 336 (ZNF336). It is a sequence-specific transcriptional repressor that binds the GZF1 responsive element (GRE), with the consensus sequence of 5'-TGCGCN[TG][CA]TATA-3'. It may play a role in renal branching morphogenesis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349520 [Multi-domain]  Cd Length: 128  Bit Score: 46.00  E-value: 6.12e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  18 NLLHGLNLLWRKQLFCDVTLTAQGQ----QFHCHKAVLASCSQYFRSLFSShpplgggvggqdglgapkdqqqqqqpqqq 93
Cdd:cd18211   11 NLLNEMHKLRLLGHLCDVTVQVEHQgskeEFSAHKAVLAASSKYFKEVFLN----------------------------- 61

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  94 ppqqqqpppqeepgtpssspdDKLLTSPRAinNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTK 173
Cdd:cd18211   62 ---------------------EKISDGKNT--NVMLNEIYTADFASFLEFVYTAKVEVEEDRVQRMLEIAEKLKCLDLSE 118


                 ....
gi 569003631 174 LCVQ 177
Cdd:cd18211  119 TCFQ 122
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 32-175 6.97e-06

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 45.03  E-value: 6.97e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  32 FCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSshpplgggvggqdglgapkdqqqqqqpqqqppqqqqpppqeePGTPSS 111
Cdd:cd18314    6 FSDVVLCVGDRKFFAHRIVLCARSPVFRSMLT------------------------------------------GSMIES 43

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 569003631 112 SpddklltspraINNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLC 175
Cdd:cd18314   44 N-----------LKEVTLEDVEPEIFETVLKYMYTGQVTLSEENVLDLLMLASKYQVPDLEKLC 96
BTB_POZ_SPOP-like cd18279
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 26-62 7.07e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349588 [Multi-domain]  Cd Length: 120  Bit Score: 45.60  E-value: 7.07e-06
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 569003631  26 LWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLF 62
Cdd:cd18279   12 LWENSRFTDCCLCVGGQEFQAHKAILAARSPVFSAMF 48
BTB_POZ_TDPOZ cd18344
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 12-62 8.80e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349653 [Multi-domain]  Cd Length: 128  Bit Score: 45.33  E-value: 8.80e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 569003631  12 DPSHSdnLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLF 62
Cdd:cd18344    5 DPRHM--LTDDLGELWENSLFTDCCLLVAGHEFRAHKAILAARSPVFRAMF 53
BTB_POZ_ZBTB43 cd18227
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-58 9.35e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349536 [Multi-domain]  Cd Length: 121  Bit Score: 45.32  E-value: 9.35e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 569003631  13 PSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYF 58
Cdd:cd18227    6 PDFSSTILQKLNQQRQQGQLCDISVVVQGHLFRAHKAVLAASSPYF 51
Kelch smart00612
Kelch domain;
376-426 9.69e-06

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 42.93  E-value: 9.69e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 569003631   376 LFVLGGedqWNpnGKHSTNFVSRYDPRFNSWIQLPPMQERRASFYACRLDK 426
Cdd:smart00612   2 IYVVGG---FD--GGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BTB_POZ_ZBTB46 cd18230
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-185 1.07e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349539 [Multi-domain]  Cd Length: 125  Bit Score: 45.05  E-value: 1.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  13 PSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSShpplgggvggqdglgapkdqqqqqqpqq 92
Cdd:cd18230    2 TSHYRHLLRELNEQRQHGILCDVCIIVEGKIFKAHKNVLLGSSRYFKTLYCQ---------------------------- 53

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  93 qppqqqqPPPQEEPGTPSSspddklltsprainnlvLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVT 172
Cdd:cd18230   54 -------VQKTSDQATVTH-----------------LDIVTAQGFKAIIDFMYSAHLALTSKNVIEVMSAASYLQMTDIV 109

                        170
                 ....*....|...
gi 569003631 173 KLCVQFLNDQISV 185
Cdd:cd18230  110 QACHNFIKAALDI 122
BTB_POZ_KLHL17_actinfilin cd18246
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1-64 1.18e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349555 [Multi-domain]  Cd Length: 139  Bit Score: 45.41  E-value: 1.18e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 569003631   1 MSRSGDRTSTFDPSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSS 64
Cdd:cd18246    8 LNRDGHSISHNSKRHYHDAFVSMNRMRQRGLLCDIVLHVGTKEIKAHKVVLASCSPYFHAMFTN 71
BTB_POZ_ZBTB27_BCL6 cd18331
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-63 1.37e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349640 [Multi-domain]  Cd Length: 118  Bit Score: 44.85  E-value: 1.37e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 569003631  15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFS 63
Cdd:cd18331    7 HASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSIFT 55
BTB1_POZ_RhoBTB cd18299
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 21-180 1.48e-05

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349608 [Multi-domain]  Cd Length: 103  Bit Score: 44.12  E-value: 1.48e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  21 HGLNLLWRKQLFCDVTLTAQGQQ-FHCHKAVLASCSQYFRSLFSSHPPLGggvggqdglgapkdqqqqqqpqqqppqqqq 99
Cdd:cd18299    1 EDLRNLLHSPSCADVVFILQGGVrIFAHRIVLAAASSVFADLFLMMTVVT------------------------------ 50

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 100 pppqeepgtpssspddklltspraINNLVLQGCssigLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFL 179
Cdd:cd18299   51 ------------------------LDSDITPEA----FRRVLEFLYTGVLDENEDDLKELKDAAELLELFDLVMMCTNVL 102


                 .
gi 569003631 180 N 180
Cdd:cd18299  103 N 103
BTB_POZ_KLHL4 cd18336
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 24-187 1.69e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349645 [Multi-domain]  Cd Length: 126  Bit Score: 44.65  E-value: 1.69e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  24 NLLWRKQLfCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHpplgggvggqdglgapkdqqqqqqpqqqppqqQQPPPQ 103
Cdd:cd18336   12 NYLQHKQL-CDVLLIAGNLKIPAHRLVLSAVSDYFAAMFTND--------------------------------VREAKQ 58

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 104 EEpgtpssspddklltsprainnLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQI 183
Cdd:cd18336   59 EE---------------------IKMEGVDPDALKALVHYAYTGVLELKEDTIESLLAAACLLQLSQVIDVCCNFLMKQL 117


                 ....
gi 569003631 184 SVQN 187
Cdd:cd18336  118 HPSN 121
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 562-604 1.80e-05

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 42.21  E-value: 1.80e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 569003631  562 RSGPGCAVLDDSIYLVGGysWSMGAYKSSTICYCPEKGTWTEL 604
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGG--FDGNQSLNSVEVYDPETNTWSKL 42
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 365-413 2.46e-05

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 41.83  E-value: 2.46e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 569003631  365 AHHCVVEVENFLFVLGGEDqwnpnGKHSTNFVSRYDPRFNSWIQLPPMQ 413
Cdd:pfam01344   3 SGAGVVVVGGKIYVIGGFD-----GNQSLNSVEVYDPETNTWSKLPSMP 46
BACK_KLHL8 cd18448
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a ...
 191-269 2.65e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN.


Pssm-ID: 350523 [Multi-domain]  Cd Length: 97  Bit Score: 43.06  E-value: 2.65e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 191 VCKIAALHGLEETKKLANKY---------LVEDVLLLNFEEMRALLDSLPPPVESELALFQMSVLWLEHDRETRMQYAPD 261
Cdd:cd18448   10 VRTFAEQHNRVDLMKMADKYacdhfnevvECEEFVSISAQHLEKLISSSDLNVESESQVYEAVMKWVKHDPQHRKRHLDD 89


                 ....*...
gi 569003631 262 LMKRLRFA 269
Cdd:cd18448   90 LLSQVRLP 97
BTB_POZ_ZBTB9 cd18200
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-58 2.88e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 9 (ZBTB9); ZBTB9 may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349509 [Multi-domain]  Cd Length: 111  Bit Score: 43.69  E-value: 2.88e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 569003631  15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYF 58
Cdd:cd18200    1 YSSALLETLNKHRLEGKFCDLSVHVQGRVFRAHKAVLAASSPYF 44
BTB_POZ_ZBTB40 cd18225
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-64 2.97e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 40 (ZBTB40); ZBTB40 may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB40 are associated with bone mineral density in European and East-Asian populations. ZBTB40 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349534 [Multi-domain]  Cd Length: 116  Bit Score: 43.66  E-value: 2.97e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 569003631  13 PSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSS 64
Cdd:cd18225    4 PNYSRQLLQQLHTLRKEQQFCDCTIFIGTFHFRAHKLVLAASSLLFKSLLDS 55
BTB_POZ_KBTBD11 cd18275
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 127-191 3.06e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11 is also called chronic myelogenous leukemia-associated protein (CMLAP) or Kelch domain-containing protein 7B, or KLHDC7C. It is a BTB-Kelch family protein whose function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349584 [Multi-domain]  Cd Length: 104  Bit Score: 43.24  E-value: 3.06e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 569003631 127 LVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQNYKQV 191
Cdd:cd18275   39 LKVKGLSYATLRLLVDYVYSGRMAVSKDNVVEVVAGARFLQMPCAAQCAVDAVRAQLCLGNCYEV 103
PRK14131 PRK14131
N-acetylneuraminate epimerase;
347-480 3.18e-05

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 46.55  E-value: 3.18e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 347 YDDEKKTWKILTIMPY-NSAHHCVVEVENFLFVLGGEDQwnPNGKHSTNFVSRYDPRFNSWIQLPPM--------QERRA 417
Cdd:PRK14131 194 YDPSTNQWKNAGESPFlGTAGSAVVIKGNKLWLINGEIK--PGLRTDAVKQGKFTGNNLKWQKLPDLppapggssQEGVA 271

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 418 SFYACRLDKHLYVIGGRNETGYLS-----------------SVECYNLDTNEWRYVSSLPQPLAAHAGAVHNGKIYISGG 480
Cdd:PRK14131 272 GAFAGYSNGVLLVAGGANFPGAREnyqngklyaheglkkswSDEIYALVNGKWQKVGELPQGLAYGVSVSWNNGVLLIGG 351
BACK_KLHL40_KBTBD5 cd18516
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also ...
 213-272 3.79e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5, or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy.


Pssm-ID: 350591 [Multi-domain]  Cd Length: 99  Bit Score: 42.82  E-value: 3.79e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 213 EDVLLLNFEEMRALLDSLPPPVESELALFQMSVLWLEHDRETRMQYAPDLMKRLRFALIP 272
Cdd:cd18516   40 EDFLQLSPDELIAIISSDSLNVEKEEDVFEAVMKWVGKDQEERTKALPVLLESIRFRLMP 99
BTB_POZ_ZBTB8 cd18199
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-63 4.29e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349508 [Multi-domain]  Cd Length: 113  Bit Score: 43.18  E-value: 4.29e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 569003631  15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFS 63
Cdd:cd18199    1 HQSRLLGQLNEQRKQDFFCDCSIIVEGRIFKAHRNVLFASSGYFRMLLS 49
Kelch_6 pfam13964
Kelch motif;
416-462 5.14e-05

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 41.17  E-value: 5.14e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 569003631  416 RASFYACRLDKHLYVIGGR-NETGYLSSVECYNLDTNEWRYVSSLPQP 462
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGYtNASPALNKLEVYNPLTKSWEELPPLPTP 49
BACK_KLHL1 cd18509
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a ...
 195-278 5.84e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton in brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350584 [Multi-domain]  Cd Length: 106  Bit Score: 42.70  E-value: 5.84e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 195 AALHGLEETKKLANKYLVEDV---------LLLNFEEMRALLDSLPPPVESELALFQMSVLWLEHDRETRMQYAPDLMKR 265
Cdd:cd18509   14 ADAQGCIELMKVAHSYTMENImevirnqefLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQRRCSDLSMLLAY 93

                         90
                 ....*....|...
gi 569003631 266 LRFALIPAPELVE 278
Cdd:cd18509   94 IRLPLLPPQLLAD 106
BTB_POZ_ZBTB22_BING1 cd18210
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-58 5.91e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 22 (ZBTB22); ZBTB22, also called protein BING1 or zinc finger protein 297, may be involved in transcriptional regulation. Its gene, together with BING 3-5, TAPASIN, DAXX, RGL2, and HKE2, form a dense cluster at the centromeric end of the major histocompatibility complex class I region. ZBTB22 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349519 [Multi-domain]  Cd Length: 112  Bit Score: 42.52  E-value: 5.91e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 569003631  13 PSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYF 58
Cdd:cd18210    2 PEITSSLLESLNQQRMEGKLCDISIHVQGRVFRAHRAVLAASSPYF 47
BTB_POZ_ZBTB14 cd18204
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-65 6.04e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14); ZBTB14 is also called zinc finger protein 161 (Zfp-161), zinc finger protein 478, zinc finger protein 5 (ZF5), or Zfp-5. It is a novel transcriptional activator of the dopamine transporter, binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. It also binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. ZBTB14 acts as a transcriptional repressor of MYC and thymidine kinase promoters. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349513 [Multi-domain]  Cd Length: 114  Bit Score: 42.72  E-value: 6.04e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 569003631  15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSH 65
Cdd:cd18204    1 HKTVFLKTLNEQRLEGEFCDIAIVVEDVKFRAHRCVLAACSTYFKKLFKKL 51
BTB_POZ_KLHL11 cd18241
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-187 7.11e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349550 [Multi-domain]  Cd Length: 135  Bit Score: 42.92  E-value: 7.11e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  21 HGLNLLWRKQ------LFCDVTLT---AQGQQFHCHKAVLASCSQYFRSLFSSHpplgggvggqdglgapkdqqqqqQPQ 91
Cdd:cd18241    6 HCSELSWRQNeqrkqgLFCDITLAfggAGGREFRAHRSVLAAATEYFTPLLSGQ-----------------------FSE 62

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  92 QQPPQQQQPPPQEEPGtpsssPDDKLLTSprainnlvlqgcssiglrlVLEYLYTANVTLSLDTVEEVLSVSKILHIPQV 171
Cdd:cd18241   63 SRSGRVEMRKWSSEPG-----PDPDTVEA-------------------VIQYMYTGRIRVSTGNVHEVLELADRFLLIRL 118

                        170
                 ....*....|....*.
gi 569003631 172 TKLCVQFLNDQISVQN 187
Cdd:cd18241  119 KEFCGEFLKKKLNLSN 134
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 513-557 7.77e-05

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 40.29  E-value: 7.77e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 569003631  513 HTLAVMNDRLYAIGGnhLKGFSHLDVmlVECYDPKGDQWNILQTP 557
Cdd:pfam01344   5 AGVVVVGGKIYVIGG--FDGNQSLNS--VEVYDPETNTWSKLPSM 45
Kelch_6 pfam13964
Kelch motif;
365-416 8.92e-05

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 40.40  E-value: 8.92e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 569003631  365 AHHCVVEVENFLFVLGGEDQWNPngkhSTNFVSRYDPRFNSWIQLPPMQERR 416
Cdd:pfam13964   3 TFHSVVSVGGYIYVFGGYTNASP----ALNKLEVYNPLTKSWEELPPLPTPR 50
BACK_KLHL32_BKLHD5 cd18471
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also ...
 187-271 9.49e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also termed BTB and kelch domain-containing protein 5 (BKLHD5), belongs to the KLHL family. Its function remains unclear. KLHL32 SNPs may be associated with body mass index in individuals of African ancestry.


Pssm-ID: 350546 [Multi-domain]  Cd Length: 98  Bit Score: 41.81  E-value: 9.49e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 187 NYKQVCKIAALHGLEETKKLANKYLV-----------EDVLLLNFEEMRALLDSLPPPVESELALFQMSVLWLEHDreTR 255
Cdd:cd18471    5 NYLDLYKLADLFNLTLLEEAVVDFLVkhlsellkshpEEVLALPYRLLREVLKSDRLTSLSEEQIWQLAVRWLEHN--CR 82

                         90
                 ....*....|....*.
gi 569003631 256 MQYAPDLMKRLRFALI 271
Cdd:cd18471   83 YQYMDELLQYVRFGLM 98
BTB_POZ_ZBTB47_ZNF651 cd18231
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 34-182 9.75e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349540 [Multi-domain]  Cd Length: 115  Bit Score: 42.22  E-value: 9.75e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  34 DVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHPPLGGGvggqdglgapkdqqqqqqpqqqppqqqqpppqeepgtpsssp 113
Cdd:cd18231   18 DIVLVRQRSTFPAHKGVLAAYSQFFHSLFTQNKQLQRV------------------------------------------ 55

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 569003631 114 ddklltsprainNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQ 182
Cdd:cd18231   56 ------------ELSLEALTSQGLQQILNFIYTSKLLVNSCNVQDVLNAAAVLQMNDIAASCQELIDSR 112
BTB_POZ_BPM_plant cd18280
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 33-62 1.05e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349589 [Multi-domain]  Cd Length: 121  Bit Score: 42.32  E-value: 1.05e-04
                         10        20        30
                 ....*....|....*....|....*....|
gi 569003631  33 CDVTLTAQGQQFHCHKAVLASCSQYFRSLF 62
Cdd:cd18280   15 ADVTFNVDGEKFRAHKLVLAARSPVFRSML 44
BTB2_POZ_BTBD8 cd18286
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 34-65 1.08e-04

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349595 [Multi-domain]  Cd Length: 121  Bit Score: 42.25  E-value: 1.08e-04
                         10        20        30
                 ....*....|....*....|....*....|..
gi 569003631  34 DVTLTAQGQQFHCHKAVLASCSQYFRSLFSSH 65
Cdd:cd18286   19 DITIKVDGKTFKAHRCILCARSSYFAAMLSGS 50
BTB_POZ_ZBTB5 cd18196
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-63 1.11e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 5 (ZBTB5); ZBTB5 is a POZ domain Kruppel-like zinc finger (POK) family transcription repressor of cell cycle arrest gene p21 and a potential proto-oncogene stimulating cell proliferation. ZBTB5 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349505 [Multi-domain]  Cd Length: 126  Bit Score: 42.34  E-value: 1.11e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 569003631  13 PSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFS 63
Cdd:cd18196    2 PGHFEQIFQQLNYQRLHGQLCDCVIVVGNRHFKAHRSVLAACSTHFRALFT 52
BACK_KBTBD12 cd18485
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 199-271 1.39e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also termed Kelch domain-containing protein 6 (KLHDC6), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350560 [Multi-domain]  Cd Length: 100  Bit Score: 41.25  E-value: 1.39e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 199 GLEETKKLANKYLV---------EDVLLLNFEEMRALLDSLPPPVESELALFQMSVLWLEHDRETRMQYAPDLMKRLRFA 269
Cdd:cd18485   17 GAEDLSDRARKYLYqhftevclhEEVLEIEAHQLLTLIKSDDLNVSREESILDLVLRWVNHNRKSRVQHLVELLKQVRLE 96


                 ..
gi 569003631 270 LI 271
Cdd:cd18485   97 LV 98
BTB_POZ_ZBTB31_myoneurin cd18217
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-175 2.36e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349526 [Multi-domain]  Cd Length: 111  Bit Score: 40.89  E-value: 2.36e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFsshpplgggvggqdglgapkdqqqqqqpqqqp 94
Cdd:cd18217    1 HCEQLLERLNKQREAGFLCDCTIVIGQFQFKAHRNVLAAFSEYFGAQY-------------------------------- 48

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  95 pqqqqpppqeepgtpSSSPDDKLLTSPRAInnlvlqgcSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKL 174
Cdd:cd18217   49 ---------------KDTEDNIVFLDQSQV--------SADGFQKLLEFIYTGNLNLDSWNVAEIHQAASYLGMEEVVAK 105


                 .
gi 569003631 175 C 175
Cdd:cd18217  106 C 106
BACK_KBTBD2 cd18479
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 175-267 3.13e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulating the insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation.


Pssm-ID: 350554 [Multi-domain]  Cd Length: 96  Bit Score: 40.42  E-value: 3.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 175 CVQFLN--DQISVQNYKQVCKIAALHgleetkKLANKYLVEDVLLLNFEEMRALLDSLPPPVESELALFQMSVLWLEHDR 252
Cdd:cd18479    6 CVRLLSfaDLFSCEELKQSAKRMVEH------KFTAVYHQEAFMQLSHDLLIDILSSDNLNVEKEETVREAAMLWLEYNT 79

                         90
                 ....*....|....*
gi 569003631 253 ETRMQYAPDLMKRLR 267
Cdd:cd18479   80 ESRSQYLSSVLSQIR 94
BTB1_POZ_BTBD7 cd18283
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 32-66 3.56e-04

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349592 [Multi-domain]  Cd Length: 92  Bit Score: 40.01  E-value: 3.56e-04
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 569003631  32 FC-DVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHP 66
Cdd:cd18283    1 YCtDVDLVFQGTCFPVHRAILSARCPFFRDLLSSSP 36
muta_rot_YjhT TIGR03547
mutatrotase, YjhT family; Members of this protein family contain multiple copies of the ...
 459-580 3.88e-04

mutatrotase, YjhT family; Members of this protein family contain multiple copies of the beta-propeller-forming Kelch repeat. All are full-length homologs to YjhT of Escherichia coli, which has been identified as a mutarotase for sialic acid. This protein improves bacterial ability to obtain host sialic acid, and thus serves as a virulence factor. Some bacteria carry what appears to be a cyclically permuted homolog of this protein.


Pssm-ID: 274641 [Multi-domain]  Cd Length: 346  Bit Score: 43.08  E-value: 3.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  459 LPQPLAAHAGAVHNGKIYI---SGGVHngeyvpWLYCYDPVMDV-WARKQDMNT-KRAIHTLAVMNDRLYAIGG---NHL 530
Cdd:TIGR03547   4 LPVGFKNGTGAIIGDKVYVglgSAGTS------WYKLDLKKPSKgWQKIADFPGgPRNQAVAAAIDGKLYVFGGigkANS 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 569003631  531 KGFSHLdVMLVECYDPKGDQWNILQTPILEGRSGPGCAVLDDS-IYLVGGY 580
Cdd:TIGR03547  78 EGSPQV-FDDVYRYDPKKNSWQKLDTRSPVGLLGASGFSLHNGqAYFTGGV 127
Kelch_6 pfam13964
Kelch motif;
464-510 4.90e-04

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 38.09  E-value: 4.90e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 569003631  464 AAHAGAVHNGKIYISGG-VHNGEYVPWLYCYDPVMDVWARKQDMNTKR 510
Cdd:pfam13964   3 TFHSVVSVGGYIYVFGGyTNASPALNKLEVYNPLTKSWEELPPLPTPR 50
PHA02713 PHA02713
hypothetical protein; Provisional
 342-447 5.07e-04

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 43.07  E-value: 5.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 342 NLVQYYDDEKKTWKILTIMPYNSAHHCVVEVENFLFVLGGEdqwnpNGKHSTNFVSRYDPRFNSWIQLPPMQERRASFYA 421
Cdd:PHA02713 320 NKVYKINIENKIHVELPPMIKNRCRFSLAVIDDTIYAIGGQ-----NGTNVERTIECYTMGDDKWKMLPDMPIALSSYGM 394

                         90       100
                 ....*....|....*....|....*.
gi 569003631 422 CRLDKHLYVIGGRNETGYLSSVECYN 447
Cdd:PHA02713 395 CVLDQYIYIIGGRTEHIDYTSVHHMN 420
BTB1_POZ_IBtk cd18301
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 34-65 5.72e-04

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349610 [Multi-domain]  Cd Length: 99  Bit Score: 39.58  E-value: 5.72e-04
                         10        20        30
                 ....*....|....*....|....*....|..
gi 569003631  34 DVTLTAQGQQFHCHKAVLASCSQYFRSLFSSH 65
Cdd:cd18301   20 DVVFQVGGKTFPAHKFILASRSDYFRKLFLSS 51
BTB_POZ_ZBTB26_Bioref cd18214
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-62 7.10e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 26 (ZBTB26); ZBTB26, also called zinc finger protein 481 (ZNF481) or zinc finger protein Bioref, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349523 [Multi-domain]  Cd Length: 122  Bit Score: 39.81  E-value: 7.10e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 569003631  14 SHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLF 62
Cdd:cd18214    7 NYGDSMLQKMNKLREQNKFCDVTVHIDDLEVPGHKVVFAAGSPFLRDQF 55
BACK_KLHL25_like cd18464
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The ...
 207-272 7.72e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The family includes KLHL25 and KLHL37. KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350539 [Multi-domain]  Cd Length: 98  Bit Score: 39.02  E-value: 7.72e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 569003631 207 ANKYLVEDVLLLNFEEMRALLDSLPPPVESELALFQMSVLWLEHDRETRMQYAPDLMKRLRFALIP 272
Cdd:cd18464   33 TTLRKTEDFLSLPKDKLLELVSSEELEVEDERLVYEAVIGWIRYDLPRRHEVLPELLRSVRLALLP 98
Kelch_2 pfam07646
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 561-607 8.63e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 462220 [Multi-domain]  Cd Length: 47  Bit Score: 37.32  E-value: 8.63e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 569003631  561 GRSGPGCAVLDDSIYLVGGYSWSMGAYKSSTICYCPEKGTWTELEGD 607
Cdd:pfam07646   1 PRYPHASSVPGGKLYVVGGSDGLGDLSSSDVLVYDPETNVWTEVPRL 47
BTB_POZ_ABTB2-like cd18297
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 34-64 1.02e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349606 [Multi-domain]  Cd Length: 117  Bit Score: 39.18  E-value: 1.02e-03
                         10        20        30
                 ....*....|....*....|....*....|.
gi 569003631  34 DVTLTAQGQQFHCHKAVLASCSQYFRSLFSS 64
Cdd:cd18297   14 DVTFLVEGRPFYAHKIVLVTASDRFKSMLSS 44
BTB_POZ_SPOPL cd18343
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-66 1.43e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349652 [Multi-domain]  Cd Length: 123  Bit Score: 39.22  E-value: 1.43e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 569003631  23 LNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFsSHP 66
Cdd:cd18343   12 LGNLWENSRFTDCSLFVGGQEFKAHKSILAARSPVFNAMF-EHE 54
BTB_POZ_ZBTB16_PLZF cd18205
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-62 1.49e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 16 (ZBTB16); ZBTB16 is also called promyelocytic leukemia zinc finger protein, zinc finger protein 145, or zinc finger protein PLZF. It is a DNA-binding transcription factor essential for undifferentiated cell maintenance. ZBTB16 also acts as a downstream transcriptional regulator of Osterix and can be useful as a late marker of osteoblastic differentiation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349514 [Multi-domain]  Cd Length: 107  Bit Score: 38.48  E-value: 1.49e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 569003631  15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLF 62
Cdd:cd18205    1 HPTGLLHKANQMRLAGTLCDVVIMVDSQEFHAHRTVLACTSKMFEILF 48
Kelch_4 pfam13418
Galactose oxidase, central domain;
567-604 1.58e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 36.82  E-value: 1.58e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 569003631  567 CAVLDDSIYLVGGYSWSMGAYkSSTICYCPEKGTWTEL 604
Cdd:pfam13418   8 TSIPDDTIYLFGGEGEDGTLL-SDLWVFDLSTNEWTRL 44
BTB_POZ_ZBTB8B cd18330
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-179 1.59e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349639 [Multi-domain]  Cd Length: 113  Bit Score: 38.75  E-value: 1.59e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  19 LLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHpplgggvggqdglgapkdqqqqqqpqqqppqqq 98
Cdd:cd18330    5 LLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALLIHY--------------------------------- 51

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  99 qpppQEEPGTPSSSPDDKLltsprainnlvlqgcSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQF 178
Cdd:cd18330   52 ----IQDSGRHSTASLDIV---------------TSEAFSIILDFLYSGKLDLCSENVIEVMSAASYLQMTDVVNFCKGY 112


                 .
gi 569003631 179 L 179
Cdd:cd18330  113 I 113
BTB_POZ cd01165
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 35-64 1.60e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


Pssm-ID: 349496 [Multi-domain]  Cd Length: 79  Bit Score: 37.65  E-value: 1.60e-03
                         10        20        30
                 ....*....|....*....|....*....|
gi 569003631  35 VTLTAQGQQFHCHKAVLASCSQYFRSLFSS 64
Cdd:cd01165    1 VVLVVEGEKFHVNKELLAQSSEYFRALFRG 30
BACK_KLHL40_like cd18477
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The ...
 213-272 1.74e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells.


Pssm-ID: 350552 [Multi-domain]  Cd Length: 99  Bit Score: 38.28  E-value: 1.74e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 213 EDVLLLNFEEMRALLDSLPPPVESELALFQMSVLWLEHDRETRMQYAPDLMKRLRFALIP 272
Cdd:cd18477   40 EDFLGLSADELIAIISSDGLNVEKEEAVFEAVMKWVREAKENRQKALPTVFESIRFRLLP 99
BTB_POZ_calicin cd18307
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 32-178 1.76e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa. It contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349616 [Multi-domain]  Cd Length: 97  Bit Score: 38.25  E-value: 1.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  32 FCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHpplgggvggqdglgapkdqqqqqqpqqqppqqqqpppqeepgtpSS 111
Cdd:cd18307    1 FCDVVISVDNHSFAAHRNVLAAVSPFVKSLISSN--------------------------------------------DM 36

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 569003631 112 SPDDKLLTSprainnLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQF 178
Cdd:cd18307   37 KATDELSIT------IDCDYLSPETVEQLLDYFYTGKIVISEKNVEDLLKGAKYFNIPRLKDHCVDF 97
Kelch_3 pfam13415
Galactose oxidase, central domain;
571-621 1.94e-03

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 36.50  E-value: 1.94e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 569003631  571 DDSIYLVGGYSWSMGAYKSSTICYCPEKGTWTELeGDVAEPLAGpACATVI 621
Cdd:pfam13415   1 GDKLYIFGGLGFDGQTRLNDLYVYDLDTNTWTQI-GDLPPPRSG-HSATYI 49
BACK_KLHL4 cd18510
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares ...
 198-277 1.97e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350585 [Multi-domain]  Cd Length: 106  Bit Score: 38.36  E-value: 1.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 198 HGLEETKKLANKYLVE---------DVLLLNFEEMRALLDSLPPPVESELALFQMSVLWLEHDRETRMQYAPDLMKRLRF 268
Cdd:cd18510   17 QGCTELLKVAHSYTMEhfleviknqEFLLLPASEIVKLLASDDINVPDEETIFQALMMWVRHDLQNRQKDLGMLLSYIRL 96


                 ....*....
gi 569003631 269 ALIPaPELV 277
Cdd:cd18510   97 PLLP-PQLL 104
BTB_POZ_BTBD3_6 cd18282
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 138-179 2.29e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This family includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349591 [Multi-domain]  Cd Length: 108  Bit Score: 38.15  E-value: 2.29e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 569003631 138 RLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFL 179
Cdd:cd18282   63 LNLLRYLYCDEIDLEPDTVLATLYAAKKYLVPHLARACVQFL 104
BACK_KLHL25_ENC2 cd18514
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also ...
 213-272 2.40e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1).


Pssm-ID: 350589 [Multi-domain]  Cd Length: 99  Bit Score: 37.90  E-value: 2.40e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 213 EDVLLLNFEEMRALLDSLPPPVESELALFQMSVLWLEHDRETRMQYAPDLMKRLRFALIP 272
Cdd:cd18514   40 EDFYSLSKDKLLDLISSDELEIEDEQVVFNAVLQWVKYDLEKRKDYLPELLRNVRLALLP 99
BTB_POZ_CP190-like cd18311
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 19-66 2.59e-03

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster centrosomal protein 190kD (CP190) and similar proteins; CP190 is a large, multi-domain protein, first identified as a centrosome protein with oscillatory localization over the course of the cell cycle. It has an essential function in the nucleus as a chromatin insulator. It is known to associate with the nuclear matrix, components of the RNAi machinery, active promoters and borders of the repressive chromatin domains. CP190 contains an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349620 [Multi-domain]  Cd Length: 110  Bit Score: 37.95  E-value: 2.59e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 569003631  19 LLHGLNLLWRKQLFCDVTLTAQ-GQQFHCHKAVLASCSQYFRSLFSSHP 66
Cdd:cd18311    1 FLQRLQNLFNKTEYCDLTLQFRdNEQLKVHRLVLSACTDYFNVLEQTCE 49
BTB_POZ_ZBTB25_ZNF46_KUP cd18213
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-62 2.71e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25); ZBTB25, also called zinc finger protein 46 (ZNF46) or zinc finger protein KUP, is a transcription repressor that facilitates viral RNA transcription and replication. It interacts with viral RNA-dependent RNA polymerase (RdRp) proteins and modulates their transcription activity. It also functions as a viral RNA-binding protein, binding preferentially to the U-rich sequence within 5' UTR of vRNA. ZBTB25 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349522 [Multi-domain]  Cd Length: 128  Bit Score: 38.34  E-value: 2.71e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 569003631  14 SHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLF 62
Cdd:cd18213    3 SHSLVLLQQLNMQREFGFLCDCTVAIGDVYFKAHRAVLAAFSNYFKMIF 51
BTB_POZ_ZBTB32_FAZF_TZFP cd18218
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-67 2.74e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 32 (ZBTB32); ZBTB32 is also called FANCC-interacting protein, fanconi anemia zinc finger protein (FAZF), testis zinc finger protein (TZFP), or zinc finger protein 538 (ZNF538). It is a DNA-binding transcription factor that binds to the 5'-TGTACAGTGT-3' core sequence. It acts as a transcription suppressor that controls T cell-mediated autoimmunity. ZBTB32 is essential for down-regulation of GATA3 via ZPO2; this promotes aggressive breast cancer development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349527 [Multi-domain]  Cd Length: 110  Bit Score: 38.00  E-value: 2.74e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 569003631  15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHPP 67
Cdd:cd18218    1 HSDRLLHLAARLRPAGALCDTLITVGSQEFPAHSLVLAGASQQLGRQLTNPNP 53
BTB_POZ_ZBTB42 cd18956
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-66 3.37e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 42 (ZBTB42); ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. It is enriched in skeletal muscles, especially at the neuromuscular junction. A ZBTB42 mutation has been identified to define a novel lethal congenital contracture syndrome (LCCS6), a lethal autosomal recessive form of arthrogryposis multiplex congenita (AMC). ZBTB42 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349737 [Multi-domain]  Cd Length: 129  Bit Score: 38.26  E-value: 3.37e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 569003631  13 PSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHP 66
Cdd:cd18956    4 PEHGGRLLGRLRQQRELGFLCDCTVLVGDARFPAHRAVLAACSVYFHLFYRDRP 57
BTB_POZ_BTBD11 cd18351
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 7-67 3.84e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 11 (BTBD11); BTBD11, also called ankyrin repeat and BTB/POZ domain-containing protein BTBD11, is a BTB-domain-containing protein. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349660 [Multi-domain]  Cd Length: 131  Bit Score: 38.04  E-value: 3.84e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 569003631   7 RTSTFDPshsdnllHGLNllwRKQLfCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHPP 67
Cdd:cd18351   10 QTSRLDP-------HFLN---NKEM-SDVTFLVEGRPFYAHKVLLFTASPRFKALLSNKPS 59
BTB_POZ_SPOP cd18342
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 26-62 4.62e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349651 [Multi-domain]  Cd Length: 125  Bit Score: 37.77  E-value: 4.62e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 569003631  26 LWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLF 62
Cdd:cd18342   16 LWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMF 52
Kelch_2 pfam07646
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 415-459 5.78e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 462220 [Multi-domain]  Cd Length: 47  Bit Score: 35.00  E-value: 5.78e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 569003631  415 RRASFYACRLDKHLYVIGGRNETG--YLSSVECYNLDTNEWRYVSSL 459
Cdd:pfam07646   1 PRYPHASSVPGGKLYVVGGSDGLGdlSSSDVLVYDPETNVWTEVPRL 47
BACK_KLHL37_ENC1 cd18515
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also ...
 213-272 7.18e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350590 [Multi-domain]  Cd Length: 98  Bit Score: 36.49  E-value: 7.18e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631 213 EDVLLLNFEEMRALLDSLPPPVESELALFQMSVLWLEHDRETRMQYAPDLMKRLRFALIP 272
Cdd:cd18515   39 EDFLQLPKDMVVQLLSSEELETEDERLVYEAAINWVNYDLKKRHCYLSELLQTVRLALLP 98
BTB_POZ_KLHL1 cd18335
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-179 8.22e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton the brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349644 [Multi-domain]  Cd Length: 126  Bit Score: 36.95  E-value: 8.22e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHpplgggvggqdglgapkdqqqqqqpqqqp 94
Cdd:cd18335    2 HAEQTFRKMESYLKQQQLCDVILIAGNRKIPAHRLVLSAVSDYFAAMFTSD----------------------------- 52

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003631  95 pqqQQPPPQEEpgtpssspddklltsprainnLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKL 174
Cdd:cd18335   53 ---VCEAKQEE---------------------IKMEGIDPNALWDLVQFAYTGCLELKEDTIENLLAAACLLQLSQVVEV 108


                 ....*
gi 569003631 175 CVQFL 179
Cdd:cd18335  109 CCHFL 113
Kelch_3 pfam13415
Galactose oxidase, central domain;
472-517 8.42e-03

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 34.57  E-value: 8.42e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 569003631  472 NGKIYISGG--VHNGEYVPWLYCYDPVMDVWARKQDMNTKRAIHTLAV 517
Cdd:pfam13415   1 GDKLYIFGGlgFDGQTRLNDLYVYDLDTNTWTQIGDLPPPRSGHSATY 48
BACK_KLHL16_gigaxonin cd18455
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, ...
 213-269 8.88e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, also termed Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy.


Pssm-ID: 350530 [Multi-domain]  Cd Length: 97  Bit Score: 36.14  E-value: 8.88e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 569003631 213 EDVLLLNFEEMRALL--DSLPppVESELALFQMSVLWLEHDRETRMQYAPDLMKRLRFA 269
Cdd:cd18455   39 EEFLELSPEKLKELLsrDKLN--VGNEEYIFEAVLRWVRHDPEERKVHLKDLMSSCWRS 95
Kelch_6 pfam13964
Kelch motif;
562-604 9.51e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 34.62  E-value: 9.51e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 569003631  562 RSGPGCAVLDDSIYLVGGYSwSMGAYKSSTICYCPEKGTWTEL 604
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGYT-NASPALNKLEVYNPLTKSWEEL 43
BTB_POZ_NPR_plant cd18310
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 16-64 9.79e-03

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349619 [Multi-domain]  Cd Length: 145  Bit Score: 36.90  E-value: 9.79e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 569003631  16 SDNLLhglNLLWRKQLFC-DVTLT-AQGQQFHCHKAVLASCSQYFRSLFSS 64
Cdd:cd18310    4 SSDLE---NLLDSPDLFYsDAEIIvEGGRPVPVHRCILAARSPFFRDIFAS 51
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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