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Conserved domains on  [gi|569003445|ref|XP_006525795|]
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solute carrier family 12 member 2 isoform X1 [Mus musculus]

Protein Classification

solute carrier family 12 protein( domain architecture ID 11489985)

solute carrier family 12 protein similar to Arabidopsis thaliana cation-chloride cotransporter 1, which mediates both potassium-chloride and sodium-chloride cotransports and is involved in plant development and Cl(-) homeostasis, or human kidney-specific Na-K-Cl symporter that mediates the transepithelial NaCl reabsorption in the thick ascending limb and plays an essential role in the urinary concentration and volume regulation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
2a30 TIGR00930
K-Cl cotransporter; [Transport and binding proteins, Other]
 210-1190 0e+00

K-Cl cotransporter; [Transport and binding proteins, Other]


:

Pssm-ID: 273347 [Multi-domain]  Cd Length: 953  Bit Score: 1614.01  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003445   210 NTMDAVPRIDHYRHTAAQLGEKLLRPSLAELHDELEKE-----PFEDGFANGEESTP---TRDAVVAYTAESKGVVKFGW 281
Cdd:TIGR00930    1 NTVDAVPRIEHYRNSEGQGGPKRNRPSLEELHDLLDKVvsllgPLADYTNNGQGMKEheeAEDAEGTKEKPPAGAVKFGW 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003445   282 IKGVLVRCMLNIWGVMLFIRLSWIVGQAGIGLSVVVIAMATVVTTITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGA 361
Cdd:TIGR00930   81 VMGVLVPCLLNIWGVILFLRLSWIVGQAGIGLSLLIILLCCCVTTITGLSMSAIATNGVVKGGGAYYLISRSLGPEFGGS 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003445   362 IGLIFAFANAVAVAMYVVGFAETVVELLKEHSI-LMIDEINDIRIIGAITVVILLGISVAGMEWEAKAQIVLLVILLLAI 440
Cdd:TIGR00930  161 IGLIFAFANAVAVAMYVVGFAETVLDLLRENGSkIMVDPINDIRIYGTVTVVVLLGISFAGMEWENKAQVLFLVIVLLSI 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003445   441 ADFVIGTFISLESKKPKGFFGYKSEIFNENFGPDFREEET-FFSVFAIFFPAATGILAGANISGDLADPQSAIPKGTLLA 519
Cdd:TIGR00930  241 LNIFVGTIIPAFDKPAKGFFGLGNEIFSENFIPGIPGPEGgFFSLFGIFFPSVTGILAGANISGDLKDPQKAIPKGTLLA 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003445   520 ILITTVVYIGIAVSVGSCVVRDATGNVNDTITTeltNCTSAACklnfdFSYCESNTCSYGLMNNFQVMSMVSGFAPLISA 599
Cdd:TIGR00930  321 ILTTTVVYLGSVVLFGACVVRDATGDKNDTLVT---NCTSAAC-----FSECAHNTCSYGLMNNLQVMSLVSPFPPLITA 392

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003445   600 GIFSATLSSALASLVSAPKIFQALCKDNIYPAFQMFAKGYGKNNEPLRGYILTFLIALGFILIAELNVIAPIISNFFLAS 679
Cdd:TIGR00930  393 GIFSATLSSALASLVSAPRLFQALCKDNIYPFLQFFGKGYGKNGEPLRAYLLTAFIAEGFILIAELNTIAPIISNFFLAS 472

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003445   680 YALINFSVFHASLAKSPGWRPAFKYYNMWISLIGAILCCIVMFVINWWAALLTYVIVLGLYIYVTYKKPDVNWGSSTQAL 759
Cdd:TIGR00930  473 YALINFSCFHASLLRSPGWRPRFKYYHWWLSLLGASLCCAIMFLISWWAALVAMVIALFLYKYVTYKKPDVNWGSSTQAL 552

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003445   760 TYLSALQHSIRLSGVEDHVKNFRPQCLVMTGSPNSRPALLHLVHDFTKNVGLMICGHVHMGPRRQAMKEMSIDQARYQRW 839
Cdd:TIGR00930  553 SYSLALYSLLRLEEVEDHVKNWRPQCLVLTGPPVCRPALLDFASQFTKGKGLMICGSVIQGPRLECVKEAQAAEAKIQTW 632

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003445   840 LIKNKMKAFYAPVHADDLREGAQYLMQAAGLGRMKPNTLVLGFKKDWLQADMRDVDMYINLFHDAFDIQFGVVVIRLKEG 919
Cdd:TIGR00930  633 LEKNKVKAFYAVVVADDLREGVRHLIQASGLGRMKPNTLVMGYKKDWRQAEPRAWETYIGIIHDAFDAHLAVVVVRNSEG 712

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003445   920 LDISHLQGQEELLssqekspgtkdvvvnVDYSKKSDQDTCKssgeksitqKESKGPIvplnvadqKLLEASTQFQKKQGK 999
Cdd:TIGR00930  713 LPISVLQVQEELE---------------NDCSEDSIELNDG---------KISTQPD--------MHLEASTQFQKKQGK 760

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003445  1000 NTIDVWWLFDDGGLTLLIPYLLTTKKKWKDCKIRVFIGG-KINRIDHDRRAMATLLSKFRIDFSDIMVLGDINTKPKKEN 1078
Cdd:TIGR00930  761 GTIDVWWLVDDGGLTLLLPYLLTTKKVWKKCKIRIFVGAqKDDRSEQEKKDMATLLYKFRIDAEVIVVLMDINAKPQTES 840

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003445  1079 IIAFDDMIEPYRLHEDDKEQDIAD-KMKEDEPWRITDNELELYKTKTYRQIRLNELLKEHSSTANIIVMSLPVARKGAVS 1157
Cdd:TIGR00930  841 MEAFEEMIRPFRLHKTEKDREAKDpKMTWTKPWKITDAELQSNVRKSYRQVRLNELLLEYSRDAALVVLSLPVPRKGSIP 920

                          970       980       990
                   ....*....|....*....|....*....|...
gi 569003445  1158 SALYMAWLEALSKDLPPVLLVRGNHQSVLTFYS 1190
Cdd:TIGR00930  921 DELYMAWLEVLSEDLPPVLLVRGNHRNVLTFYS 953
PRK07764 super family cl35613
DNA polymerase III subunits gamma and tau; Validated
 3-74 7.54e-03

DNA polymerase III subunits gamma and tau; Validated


The actual alignment was detected with superfamily member PRK07764:

Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 40.35  E-value: 7.54e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 569003445    3 PGPAAPSSGAPRPARDGDAPLAAAAGV-DLPGTAVPSGQEDATTAGRQAGggvRGEGTPAAGDGLGRPLGPTP 74
Cdd:PRK07764  676 AAPAAPPPAPAPAAPAAPAGAAPAQPApAPAATPPAGQADDPAAQPPQAA---QGASAPSPAADDPVPLPPEP 745
 
Name Accession Description Interval E-value
2a30 TIGR00930
K-Cl cotransporter; [Transport and binding proteins, Other]
 210-1190 0e+00

K-Cl cotransporter; [Transport and binding proteins, Other]


Pssm-ID: 273347 [Multi-domain]  Cd Length: 953  Bit Score: 1614.01  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003445   210 NTMDAVPRIDHYRHTAAQLGEKLLRPSLAELHDELEKE-----PFEDGFANGEESTP---TRDAVVAYTAESKGVVKFGW 281
Cdd:TIGR00930    1 NTVDAVPRIEHYRNSEGQGGPKRNRPSLEELHDLLDKVvsllgPLADYTNNGQGMKEheeAEDAEGTKEKPPAGAVKFGW 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003445   282 IKGVLVRCMLNIWGVMLFIRLSWIVGQAGIGLSVVVIAMATVVTTITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGA 361
Cdd:TIGR00930   81 VMGVLVPCLLNIWGVILFLRLSWIVGQAGIGLSLLIILLCCCVTTITGLSMSAIATNGVVKGGGAYYLISRSLGPEFGGS 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003445   362 IGLIFAFANAVAVAMYVVGFAETVVELLKEHSI-LMIDEINDIRIIGAITVVILLGISVAGMEWEAKAQIVLLVILLLAI 440
Cdd:TIGR00930  161 IGLIFAFANAVAVAMYVVGFAETVLDLLRENGSkIMVDPINDIRIYGTVTVVVLLGISFAGMEWENKAQVLFLVIVLLSI 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003445   441 ADFVIGTFISLESKKPKGFFGYKSEIFNENFGPDFREEET-FFSVFAIFFPAATGILAGANISGDLADPQSAIPKGTLLA 519
Cdd:TIGR00930  241 LNIFVGTIIPAFDKPAKGFFGLGNEIFSENFIPGIPGPEGgFFSLFGIFFPSVTGILAGANISGDLKDPQKAIPKGTLLA 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003445   520 ILITTVVYIGIAVSVGSCVVRDATGNVNDTITTeltNCTSAACklnfdFSYCESNTCSYGLMNNFQVMSMVSGFAPLISA 599
Cdd:TIGR00930  321 ILTTTVVYLGSVVLFGACVVRDATGDKNDTLVT---NCTSAAC-----FSECAHNTCSYGLMNNLQVMSLVSPFPPLITA 392

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003445   600 GIFSATLSSALASLVSAPKIFQALCKDNIYPAFQMFAKGYGKNNEPLRGYILTFLIALGFILIAELNVIAPIISNFFLAS 679
Cdd:TIGR00930  393 GIFSATLSSALASLVSAPRLFQALCKDNIYPFLQFFGKGYGKNGEPLRAYLLTAFIAEGFILIAELNTIAPIISNFFLAS 472

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003445   680 YALINFSVFHASLAKSPGWRPAFKYYNMWISLIGAILCCIVMFVINWWAALLTYVIVLGLYIYVTYKKPDVNWGSSTQAL 759
Cdd:TIGR00930  473 YALINFSCFHASLLRSPGWRPRFKYYHWWLSLLGASLCCAIMFLISWWAALVAMVIALFLYKYVTYKKPDVNWGSSTQAL 552

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003445   760 TYLSALQHSIRLSGVEDHVKNFRPQCLVMTGSPNSRPALLHLVHDFTKNVGLMICGHVHMGPRRQAMKEMSIDQARYQRW 839
Cdd:TIGR00930  553 SYSLALYSLLRLEEVEDHVKNWRPQCLVLTGPPVCRPALLDFASQFTKGKGLMICGSVIQGPRLECVKEAQAAEAKIQTW 632

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003445   840 LIKNKMKAFYAPVHADDLREGAQYLMQAAGLGRMKPNTLVLGFKKDWLQADMRDVDMYINLFHDAFDIQFGVVVIRLKEG 919
Cdd:TIGR00930  633 LEKNKVKAFYAVVVADDLREGVRHLIQASGLGRMKPNTLVMGYKKDWRQAEPRAWETYIGIIHDAFDAHLAVVVVRNSEG 712

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003445   920 LDISHLQGQEELLssqekspgtkdvvvnVDYSKKSDQDTCKssgeksitqKESKGPIvplnvadqKLLEASTQFQKKQGK 999
Cdd:TIGR00930  713 LPISVLQVQEELE---------------NDCSEDSIELNDG---------KISTQPD--------MHLEASTQFQKKQGK 760

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003445  1000 NTIDVWWLFDDGGLTLLIPYLLTTKKKWKDCKIRVFIGG-KINRIDHDRRAMATLLSKFRIDFSDIMVLGDINTKPKKEN 1078
Cdd:TIGR00930  761 GTIDVWWLVDDGGLTLLLPYLLTTKKVWKKCKIRIFVGAqKDDRSEQEKKDMATLLYKFRIDAEVIVVLMDINAKPQTES 840

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003445  1079 IIAFDDMIEPYRLHEDDKEQDIAD-KMKEDEPWRITDNELELYKTKTYRQIRLNELLKEHSSTANIIVMSLPVARKGAVS 1157
Cdd:TIGR00930  841 MEAFEEMIRPFRLHKTEKDREAKDpKMTWTKPWKITDAELQSNVRKSYRQVRLNELLLEYSRDAALVVLSLPVPRKGSIP 920

                          970       980       990
                   ....*....|....*....|....*....|...
gi 569003445  1158 SALYMAWLEALSKDLPPVLLVRGNHQSVLTFYS 1190
Cdd:TIGR00930  921 DELYMAWLEVLSEDLPPVLLVRGNHRNVLTFYS 953
SLC12 pfam03522
Solute carrier family 12;
795-1190 0e+00

Solute carrier family 12;


Pssm-ID: 460955  Cd Length: 414  Bit Score: 649.68  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003445   795 RPALLHLVHDFTKNVGLMICGHVHMGPRRQAMKEMSidQARYQRWLIKNKMKAFYAPVHADDLREGAQYLMQAAGLGRMK 874
Cdd:pfam03522    1 RPALVDFAHLITKNVSLMICGHVVKGRLSQKLRSEL--QKKAYRWLRKRKIKAFYALVDGDNLREGAQALLQASGLGKLK 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003445   875 PNTLVLGFKKDWLQADMRDVDMYINLFHDAFDIQFGVVVIRLKEGLDISHLQGQE---ELLSSQEKSPGTKDVVVNVDYS 951
Cdd:pfam03522   79 PNILLMGYKSDWRTCDKEELEEYFNVIHDAFDLQYAVAILRLPEGLDVSHLLQDQdteELGLGDETNSSYAEQSSEEQST 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003445   952 KKSDQDTCKSSGEKS------ITQKESKGPIVPLNVADQKL------------------LEASTQFQKKQGKNTIDVWWL 1007
Cdd:pfam03522  159 SNSKQDDDKSKLSKKdsnlslSPDKSTKNPSGKDSSKSDKLkkkspsiilrtasnekeiLNNITQFQKKQKKGTIDVWWL 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003445  1008 FDDGGLTLLIPYLLTTKKKWKDCKIRVFIGG-KINRIDHDRRAMATLLSKFRIDFSDIMVLGDINTKPKKENIIAFDDMI 1086
Cdd:pfam03522  239 YDDGGLTLLLPYILSTRSKWSDCKLRVFALGnRKDELEEEQRNMASLLSKFRIDYSDLTVIPDITKKPKKETKKFFDELI 318

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003445  1087 EPYRLHEDDKEQDIAdkmkedepWRITDNELELYKTKTYRQIRLNELLKEHSSTANIIVMSLPVARKGAVSSALYMAWLE 1166
Cdd:pfam03522  319 EPFRLHEDDKEEESA--------EKITDSELEALKEKTNRQLRLRELLLEHSSDANLIVMTLPMPRKGTVSAPLYMAWLE 390

                          410       420
                   ....*....|....*....|....
gi 569003445  1167 ALSKDLPPVLLVRGNHQSVLTFYS 1190
Cdd:pfam03522  391 TLTKDLPPFLLVRGNQTSVLTFYS 414
PotE COG0531
Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];
292-747 1.83e-43

Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];


Pssm-ID: 440297 [Multi-domain]  Cd Length: 438  Bit Score: 164.69  E-value: 1.83e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003445  292 NIWGVMLFIRLSWIVGQAGiGLSVVVIAMATVVTTITGLSTSAIATNgFVRGGGAYYLISRSLGPEFGGAIGLIFAFANA 371
Cdd:COG0531    25 AIIGAGIFVLPGLAAGLAG-PAAILAWLIAGLLALLVALSYAELASA-FPRAGGAYTYARRALGPLLGFLAGWALLLSYV 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003445  372 VAVAMYVVGFAETVVELLKEHSILmideindirIIGAITVVILLGISVAGMEWEAKAQIVLLVILLlaiadFVIGTFISL 451
Cdd:COG0531   103 LAVAAVAVAFGGYLSSLFPAGGSV---------LIALVLILLLTLLNLRGVKESAKVNNILTVLKL-----LVLLLFIVV 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003445  452 eskkpkGFFGYKSEIFNeNFGPDFREEETFFSVFAIFFPAATGILAGANISGDLADPQSAIPKGTLLAILITTVVYIGIA 531
Cdd:COG0531   169 ------GLFAFDPANFT-PFLPAGGGLSGVLAALALAFFAFTGFEAIANLAEEAKNPKRNIPRAIILSLLIVGVLYILVS 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003445  532 VSVGSCVVRDATGNVNDTItteltnctsaacklnfdfsycesntcsyglmnnFQVMSMVSG--FAPLISAGIFSATLSSA 609
Cdd:COG0531   242 LALTGVVPYDELAASGAPL---------------------------------ADAAEAVFGpwGAILIALGALLSLLGAL 288

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003445  610 LASLVSAPKIFQALCKDNIYPAFqmFAKGYGKNNEPLRGYILTFLIALGFILI--AELNVIAPIISNFFLASYALINFSV 687
Cdd:COG0531   289 NASILGASRLLYAMARDGLLPKV--FAKVHPRFGTPVNAILLTGVIALLLLLLgaASFTALASLASVGVLLAYLLVALAV 366

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 569003445  688 FhASLAKSPGWRPAFKYYNMWISLIGAILCCIVMFVINWWAALLTYV-IVLGLYIYVTYKK 747
Cdd:COG0531   367 I-VLRRRRPDLPRPFRVPLPLIPILGILLCLFLLYLLGPGALLIGLVlLAIGLLLYLLYRR 426
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 3-74 7.54e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 40.35  E-value: 7.54e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 569003445    3 PGPAAPSSGAPRPARDGDAPLAAAAGV-DLPGTAVPSGQEDATTAGRQAGggvRGEGTPAAGDGLGRPLGPTP 74
Cdd:PRK07764  676 AAPAAPPPAPAPAAPAAPAGAAPAQPApAPAATPPAGQADDPAAQPPQAA---QGASAPSPAADDPVPLPPEP 745
 
Name Accession Description Interval E-value
2a30 TIGR00930
K-Cl cotransporter; [Transport and binding proteins, Other]
 210-1190 0e+00

K-Cl cotransporter; [Transport and binding proteins, Other]


Pssm-ID: 273347 [Multi-domain]  Cd Length: 953  Bit Score: 1614.01  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003445   210 NTMDAVPRIDHYRHTAAQLGEKLLRPSLAELHDELEKE-----PFEDGFANGEESTP---TRDAVVAYTAESKGVVKFGW 281
Cdd:TIGR00930    1 NTVDAVPRIEHYRNSEGQGGPKRNRPSLEELHDLLDKVvsllgPLADYTNNGQGMKEheeAEDAEGTKEKPPAGAVKFGW 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003445   282 IKGVLVRCMLNIWGVMLFIRLSWIVGQAGIGLSVVVIAMATVVTTITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGA 361
Cdd:TIGR00930   81 VMGVLVPCLLNIWGVILFLRLSWIVGQAGIGLSLLIILLCCCVTTITGLSMSAIATNGVVKGGGAYYLISRSLGPEFGGS 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003445   362 IGLIFAFANAVAVAMYVVGFAETVVELLKEHSI-LMIDEINDIRIIGAITVVILLGISVAGMEWEAKAQIVLLVILLLAI 440
Cdd:TIGR00930  161 IGLIFAFANAVAVAMYVVGFAETVLDLLRENGSkIMVDPINDIRIYGTVTVVVLLGISFAGMEWENKAQVLFLVIVLLSI 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003445   441 ADFVIGTFISLESKKPKGFFGYKSEIFNENFGPDFREEET-FFSVFAIFFPAATGILAGANISGDLADPQSAIPKGTLLA 519
Cdd:TIGR00930  241 LNIFVGTIIPAFDKPAKGFFGLGNEIFSENFIPGIPGPEGgFFSLFGIFFPSVTGILAGANISGDLKDPQKAIPKGTLLA 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003445   520 ILITTVVYIGIAVSVGSCVVRDATGNVNDTITTeltNCTSAACklnfdFSYCESNTCSYGLMNNFQVMSMVSGFAPLISA 599
Cdd:TIGR00930  321 ILTTTVVYLGSVVLFGACVVRDATGDKNDTLVT---NCTSAAC-----FSECAHNTCSYGLMNNLQVMSLVSPFPPLITA 392

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003445   600 GIFSATLSSALASLVSAPKIFQALCKDNIYPAFQMFAKGYGKNNEPLRGYILTFLIALGFILIAELNVIAPIISNFFLAS 679
Cdd:TIGR00930  393 GIFSATLSSALASLVSAPRLFQALCKDNIYPFLQFFGKGYGKNGEPLRAYLLTAFIAEGFILIAELNTIAPIISNFFLAS 472

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003445   680 YALINFSVFHASLAKSPGWRPAFKYYNMWISLIGAILCCIVMFVINWWAALLTYVIVLGLYIYVTYKKPDVNWGSSTQAL 759
Cdd:TIGR00930  473 YALINFSCFHASLLRSPGWRPRFKYYHWWLSLLGASLCCAIMFLISWWAALVAMVIALFLYKYVTYKKPDVNWGSSTQAL 552

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003445   760 TYLSALQHSIRLSGVEDHVKNFRPQCLVMTGSPNSRPALLHLVHDFTKNVGLMICGHVHMGPRRQAMKEMSIDQARYQRW 839
Cdd:TIGR00930  553 SYSLALYSLLRLEEVEDHVKNWRPQCLVLTGPPVCRPALLDFASQFTKGKGLMICGSVIQGPRLECVKEAQAAEAKIQTW 632

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003445   840 LIKNKMKAFYAPVHADDLREGAQYLMQAAGLGRMKPNTLVLGFKKDWLQADMRDVDMYINLFHDAFDIQFGVVVIRLKEG 919
Cdd:TIGR00930  633 LEKNKVKAFYAVVVADDLREGVRHLIQASGLGRMKPNTLVMGYKKDWRQAEPRAWETYIGIIHDAFDAHLAVVVVRNSEG 712

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003445   920 LDISHLQGQEELLssqekspgtkdvvvnVDYSKKSDQDTCKssgeksitqKESKGPIvplnvadqKLLEASTQFQKKQGK 999
Cdd:TIGR00930  713 LPISVLQVQEELE---------------NDCSEDSIELNDG---------KISTQPD--------MHLEASTQFQKKQGK 760

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003445  1000 NTIDVWWLFDDGGLTLLIPYLLTTKKKWKDCKIRVFIGG-KINRIDHDRRAMATLLSKFRIDFSDIMVLGDINTKPKKEN 1078
Cdd:TIGR00930  761 GTIDVWWLVDDGGLTLLLPYLLTTKKVWKKCKIRIFVGAqKDDRSEQEKKDMATLLYKFRIDAEVIVVLMDINAKPQTES 840

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003445  1079 IIAFDDMIEPYRLHEDDKEQDIAD-KMKEDEPWRITDNELELYKTKTYRQIRLNELLKEHSSTANIIVMSLPVARKGAVS 1157
Cdd:TIGR00930  841 MEAFEEMIRPFRLHKTEKDREAKDpKMTWTKPWKITDAELQSNVRKSYRQVRLNELLLEYSRDAALVVLSLPVPRKGSIP 920

                          970       980       990
                   ....*....|....*....|....*....|...
gi 569003445  1158 SALYMAWLEALSKDLPPVLLVRGNHQSVLTFYS 1190
Cdd:TIGR00930  921 DELYMAWLEVLSEDLPPVLLVRGNHRNVLTFYS 953
SLC12 pfam03522
Solute carrier family 12;
795-1190 0e+00

Solute carrier family 12;


Pssm-ID: 460955  Cd Length: 414  Bit Score: 649.68  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003445   795 RPALLHLVHDFTKNVGLMICGHVHMGPRRQAMKEMSidQARYQRWLIKNKMKAFYAPVHADDLREGAQYLMQAAGLGRMK 874
Cdd:pfam03522    1 RPALVDFAHLITKNVSLMICGHVVKGRLSQKLRSEL--QKKAYRWLRKRKIKAFYALVDGDNLREGAQALLQASGLGKLK 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003445   875 PNTLVLGFKKDWLQADMRDVDMYINLFHDAFDIQFGVVVIRLKEGLDISHLQGQE---ELLSSQEKSPGTKDVVVNVDYS 951
Cdd:pfam03522   79 PNILLMGYKSDWRTCDKEELEEYFNVIHDAFDLQYAVAILRLPEGLDVSHLLQDQdteELGLGDETNSSYAEQSSEEQST 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003445   952 KKSDQDTCKSSGEKS------ITQKESKGPIVPLNVADQKL------------------LEASTQFQKKQGKNTIDVWWL 1007
Cdd:pfam03522  159 SNSKQDDDKSKLSKKdsnlslSPDKSTKNPSGKDSSKSDKLkkkspsiilrtasnekeiLNNITQFQKKQKKGTIDVWWL 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003445  1008 FDDGGLTLLIPYLLTTKKKWKDCKIRVFIGG-KINRIDHDRRAMATLLSKFRIDFSDIMVLGDINTKPKKENIIAFDDMI 1086
Cdd:pfam03522  239 YDDGGLTLLLPYILSTRSKWSDCKLRVFALGnRKDELEEEQRNMASLLSKFRIDYSDLTVIPDITKKPKKETKKFFDELI 318

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003445  1087 EPYRLHEDDKEQDIAdkmkedepWRITDNELELYKTKTYRQIRLNELLKEHSSTANIIVMSLPVARKGAVSSALYMAWLE 1166
Cdd:pfam03522  319 EPFRLHEDDKEEESA--------EKITDSELEALKEKTNRQLRLRELLLEHSSDANLIVMTLPMPRKGTVSAPLYMAWLE 390

                          410       420
                   ....*....|....*....|....
gi 569003445  1167 ALSKDLPPVLLVRGNHQSVLTFYS 1190
Cdd:pfam03522  391 TLTKDLPPFLLVRGNQTSVLTFYS 414
AA_permease pfam00324
Amino acid permease;
284-786 3.18e-131

Amino acid permease;


Pssm-ID: 366028 [Multi-domain]  Cd Length: 467  Bit Score: 409.02  E-value: 3.18e-131
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003445   284 GVLVRCMLNIWGVMLFIRLSWIVGQAGIGLSVVVIAMATVVTTITGLSTSAIATNGFVrGGGAYYLISRSLGPEFGGAIG 363
Cdd:pfam00324    1 HVQMIALGGVIGTGLFVGSGSVLGQAGPAGALLGYLISGVVIFLVMLSLGEISTNGPV-SGGFYTYASRFLGPSLGFATG 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003445   364 LIFAFanavavaMYVVGFA-ETVVELLKEHSILMIDEINDIRIIGAITVVILLGISVAGMEWEAKAQIVLLVILLLAIAD 442
Cdd:pfam00324   80 WNYWL-------SWITVLAlELTAASILIQFWELVPDIPYLWVWGAVFLVLLTIINLVGVKWYGEAEFWFALIKIIAIIG 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003445   443 FVIGTFISLESKKPK---GFFGYKSEIFNENFGPDFreEETFFSVFAIFFPAATGILAGANISGDLADPQSAIPKGTLLA 519
Cdd:pfam00324  153 FIIVGIILLSGGNPNdgaIFRYLGDNGGKNNFPPGF--GKGFISVFVIAFFAFTGIELVGIAAGEVKNPEKSIPKAILQV 230

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003445   520 ILITTVVYIGIAVSVGSCVVRDATGNVNDTITTeltnctsaacklnfdfsycesntcsYGLMNNFQVMSMVSGFAPLISA 599
Cdd:pfam00324  231 IWRITIFYILSLLAIGLLVPWNDPGLLNDSASA-------------------------ASPFVIFFKFLGISGLAPLINA 285

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003445   600 GIFSATLSSALASLVSAPKIFQALCKDNIYPafqMFAKGYGKNNEPLRGYILTFLIALGFILIAELNviAPIISNFFLAS 679
Cdd:pfam00324  286 VILTAALSAANSSLYSGSRMLYSLARDGLAP---KFLKKVDKRGVPLRAILVSMVISLLALLLASLN--PAIVFNFLLAI 360

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003445   680 YALINFSVFHASLAKSPGWRPAFKYYNMWISLIGAILCCIVMFVINWWAALLTYVIVLGLYIYVTYKKPDVNWGSSTQAL 759
Cdd:pfam00324  361 SGLSGLIVWGLISLSHLRFRKAFKYQGRSIDELPFKAPLGPLGVILGLAAIIIILIIQFLYAFLPVPGGPKNWGAGSFAA 440

                          490       500
                   ....*....|....*....|....*..
gi 569003445   760 TYLSALQHSIRLSGVEDHVKNFRPQCL 786
Cdd:pfam00324  441 AYLIVLLFLIILIGVKLHVKNWKPQLL 467
PotE COG0531
Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];
292-747 1.83e-43

Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];


Pssm-ID: 440297 [Multi-domain]  Cd Length: 438  Bit Score: 164.69  E-value: 1.83e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003445  292 NIWGVMLFIRLSWIVGQAGiGLSVVVIAMATVVTTITGLSTSAIATNgFVRGGGAYYLISRSLGPEFGGAIGLIFAFANA 371
Cdd:COG0531    25 AIIGAGIFVLPGLAAGLAG-PAAILAWLIAGLLALLVALSYAELASA-FPRAGGAYTYARRALGPLLGFLAGWALLLSYV 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003445  372 VAVAMYVVGFAETVVELLKEHSILmideindirIIGAITVVILLGISVAGMEWEAKAQIVLLVILLlaiadFVIGTFISL 451
Cdd:COG0531   103 LAVAAVAVAFGGYLSSLFPAGGSV---------LIALVLILLLTLLNLRGVKESAKVNNILTVLKL-----LVLLLFIVV 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003445  452 eskkpkGFFGYKSEIFNeNFGPDFREEETFFSVFAIFFPAATGILAGANISGDLADPQSAIPKGTLLAILITTVVYIGIA 531
Cdd:COG0531   169 ------GLFAFDPANFT-PFLPAGGGLSGVLAALALAFFAFTGFEAIANLAEEAKNPKRNIPRAIILSLLIVGVLYILVS 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003445  532 VSVGSCVVRDATGNVNDTItteltnctsaacklnfdfsycesntcsyglmnnFQVMSMVSG--FAPLISAGIFSATLSSA 609
Cdd:COG0531   242 LALTGVVPYDELAASGAPL---------------------------------ADAAEAVFGpwGAILIALGALLSLLGAL 288

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003445  610 LASLVSAPKIFQALCKDNIYPAFqmFAKGYGKNNEPLRGYILTFLIALGFILI--AELNVIAPIISNFFLASYALINFSV 687
Cdd:COG0531   289 NASILGASRLLYAMARDGLLPKV--FAKVHPRFGTPVNAILLTGVIALLLLLLgaASFTALASLASVGVLLAYLLVALAV 366

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 569003445  688 FhASLAKSPGWRPAFKYYNMWISLIGAILCCIVMFVINWWAALLTYV-IVLGLYIYVTYKK 747
Cdd:COG0531   367 I-VLRRRRPDLPRPFRVPLPLIPILGILLCLFLLYLLGPGALLIGLVlLAIGLLLYLLYRR 426
AA_permease_N pfam08403
Amino acid permease N-terminal; This domain is found to the N-terminus of the amino acid ...
 196-258 1.08e-32

Amino acid permease N-terminal; This domain is found to the N-terminus of the amino acid permease domain (pfam00324) in metazoan Na-K-Cl cotransporters.


Pssm-ID: 429977  Cd Length: 70  Bit Score: 121.01  E-value: 1.08e-32
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003445   196 DTHTNTYYLRTFGHNTMDAVPRIDHYRHTAAQLGEKLLRPSLAELHDELEK-------EPFEDGFANGEE 258
Cdd:pfam08403    1 DTHGSTYYLQTFGHNTLDAVPRIDFYRNTGSVSGVKKSRPSLAELHSQLKKnsalavaEGSVDGVENGDG 70
AA_permease_2 pfam13520
Amino acid permease;
309-729 2.82e-15

Amino acid permease;


Pssm-ID: 404414 [Multi-domain]  Cd Length: 427  Bit Score: 79.66  E-value: 2.82e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003445   309 AGIGLSVVVIAMATVVTTITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGAIGLIFAFANAVAVAMYVVGFAETVVEL 388
Cdd:pfam13520   27 SGGPALIVWGWIAAIIFSLAVGLVYAELSSALPRSGGIYVYLENAFGKFVAFLAGWSNWFAYVLGLASSASVAASYLLSA 106

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003445   389 LKEhsiLMIDEINDIRIIGAITVVILLGISVAGMEWEAKAQIVLLVILLLAIADFVIGTFIsleskkPKGFFGYKSEIFN 468
Cdd:pfam13520  107 LGP---DLVPTTWLTYGIAIAILIIFAIINIRGVRESAKIQNILGILKLLLPLILIIILGL------VTADGGGFNLLSG 177

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003445   469 E--NFGPDFreEETFFSVFAIFFPAATGILAGANISGDlaDPQSAIPKGTLLAILITTVVYIGIAVSVGSCVVRDATGNV 546
Cdd:pfam13520  178 EwhTFFPDG--WPGVFAGFLGVLWSFTGFESAANVSEE--VKKRNVPKAIFIGVIIVGVLYILVNIAFFGVVPDDEIALS 253

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003445   547 NDTITTeltnctsaacklnfdfsycesntcsYGLMnnFQvMSMVSGFAPLISAGIFSATLSSALASLVSAPKIFQALCKD 626
Cdd:pfam13520  254 SGLGQV-------------------------AALL--FQ-AVGGKWGAIIVVILLALSLLGAVNTAIVGASRLLYALARD 305

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569003445   627 NIYPAFQMFAKgYGKNNEPLRGYILTFLIALGFILIAelnVIAPIISNFFLASYALINFSVFHASLA-------KSPGWR 699
Cdd:pfam13520  306 GVLPFSRFFAK-VNKFGSPIRAIILTAILSLILLLLF---LLSPAAYNALLSLSAYGYLLSYLLPIIgllilrkKRPDLG 381

                          410       420       430
                   ....*....|....*....|....*....|
gi 569003445   700 pafKYYNMWISLIGAILCCIVMFVINWWAA 729
Cdd:pfam13520  382 ---RIPGRWPVAIFGILFSLFLIVALFFPP 408
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 3-74 7.54e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 40.35  E-value: 7.54e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 569003445    3 PGPAAPSSGAPRPARDGDAPLAAAAGV-DLPGTAVPSGQEDATTAGRQAGggvRGEGTPAAGDGLGRPLGPTP 74
Cdd:PRK07764  676 AAPAAPPPAPAPAAPAAPAGAAPAQPApAPAATPPAGQADDPAAQPPQAA---QGASAPSPAADDPVPLPPEP 745
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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