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Conserved domains on  [gi|569001197|ref|XP_006524779|]
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tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 isoform X1 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 60-272 1.46e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 73.91  E-value: 1.46e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001197  60 RGGSRFLAFST------TGSDDDCVFTYDCSTAEKKATPEDKgedgqpadtgSDSILASTFSKSGRYFALTDDSKRLILF 133
Cdd:cd00200    9 TGGVTCVAFSPdgkllaTGSGDGTIKVWDLETGELLRTLKGH----------TGPVRDVAASADGTYLASGSSDKTIRLW 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001197 134 RTKPWQCLSV-RMVVRRCTALTFTASeDRVLVA---DKSGDVYSFsvlEPDGCGRLELGHLSMLLDVAVSPDDQFVLTAD 209
Cdd:cd00200   79 DLETGECVRTlTGHTSYVSSVAFSPD-GRILSSssrDKTIKVWDV---ETGKCLTTLRGHTDWVNSVAFSPDGTFVASSS 154

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 569001197 210 RDEKIRVsWAAAPHSIESFCLGHTEFVSRILVVPShPELLLSSSGDGTLRLWEYRSGRQLQCC 272
Cdd:cd00200  155 QDGTIKL-WDLRTGKCVATLTGHTGEVNSVAFSPD-GEKLLSSSSDGTIKLWDLSTGKCLGTL 215
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 60-272 1.46e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 73.91  E-value: 1.46e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001197  60 RGGSRFLAFST------TGSDDDCVFTYDCSTAEKKATPEDKgedgqpadtgSDSILASTFSKSGRYFALTDDSKRLILF 133
Cdd:cd00200    9 TGGVTCVAFSPdgkllaTGSGDGTIKVWDLETGELLRTLKGH----------TGPVRDVAASADGTYLASGSSDKTIRLW 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001197 134 RTKPWQCLSV-RMVVRRCTALTFTASeDRVLVA---DKSGDVYSFsvlEPDGCGRLELGHLSMLLDVAVSPDDQFVLTAD 209
Cdd:cd00200   79 DLETGECVRTlTGHTSYVSSVAFSPD-GRILSSssrDKTIKVWDV---ETGKCLTTLRGHTDWVNSVAFSPDGTFVASSS 154

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 569001197 210 RDEKIRVsWAAAPHSIESFCLGHTEFVSRILVVPShPELLLSSSGDGTLRLWEYRSGRQLQCC 272
Cdd:cd00200  155 QDGTIKL-WDLRTGKCVATLTGHTGEVNSVAFSPD-GEKLLSSSSDGTIKLWDLSTGKCLGTL 215
WD40 COG2319
WD40 repeat [General function prediction only];
63-261 5.12e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 73.41  E-value: 5.12e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001197  63 SRFLAfstTGSDDDCVFTYDCSTAEKKATPEDkgedgqpadtGSDSILASTFSKSGRYFALTDDSKRLILFRTKPWQCL- 141
Cdd:COG2319  216 GKLLA---SGSADGTVRLWDLATGKLLRTLTG----------HSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLr 282

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001197 142 SVRMVVRRCTALTFTASEDRVLVADKSGDVYSFSVLEPDGCGRLElGHLSMLLDVAVSPDDQFVLTADRDEKIRVsWAAA 221
Cdd:COG2319  283 TLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT-GHTGAVRSVAFSPDGKTLASGSDDGTVRL-WDLA 360

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 569001197 222 PHSIESFCLGHTEFVSRILVVPSHpELLLSSSGDGTLRLW 261
Cdd:COG2319  361 TGELLRTLTGHTGAVTSVAFSPDG-RTLASGSADGTVRLW 399
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 231-262 8.03e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.21  E-value: 8.03e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 569001197   231 GHTEFVSRILVVPSHPeLLLSSSGDGTLRLWE 262
Cdd:smart00320  10 GHTGPVTSVAFSPDGK-YLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 60-272 1.46e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 73.91  E-value: 1.46e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001197  60 RGGSRFLAFST------TGSDDDCVFTYDCSTAEKKATPEDKgedgqpadtgSDSILASTFSKSGRYFALTDDSKRLILF 133
Cdd:cd00200    9 TGGVTCVAFSPdgkllaTGSGDGTIKVWDLETGELLRTLKGH----------TGPVRDVAASADGTYLASGSSDKTIRLW 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001197 134 RTKPWQCLSV-RMVVRRCTALTFTASeDRVLVA---DKSGDVYSFsvlEPDGCGRLELGHLSMLLDVAVSPDDQFVLTAD 209
Cdd:cd00200   79 DLETGECVRTlTGHTSYVSSVAFSPD-GRILSSssrDKTIKVWDV---ETGKCLTTLRGHTDWVNSVAFSPDGTFVASSS 154

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 569001197 210 RDEKIRVsWAAAPHSIESFCLGHTEFVSRILVVPShPELLLSSSGDGTLRLWEYRSGRQLQCC 272
Cdd:cd00200  155 QDGTIKL-WDLRTGKCVATLTGHTGEVNSVAFSPD-GEKLLSSSSDGTIKLWDLSTGKCLGTL 215
WD40 COG2319
WD40 repeat [General function prediction only];
63-261 5.12e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 73.41  E-value: 5.12e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001197  63 SRFLAfstTGSDDDCVFTYDCSTAEKKATPEDkgedgqpadtGSDSILASTFSKSGRYFALTDDSKRLILFRTKPWQCL- 141
Cdd:COG2319  216 GKLLA---SGSADGTVRLWDLATGKLLRTLTG----------HSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLr 282

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001197 142 SVRMVVRRCTALTFTASEDRVLVADKSGDVYSFSVLEPDGCGRLElGHLSMLLDVAVSPDDQFVLTADRDEKIRVsWAAA 221
Cdd:COG2319  283 TLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT-GHTGAVRSVAFSPDGKTLASGSDDGTVRL-WDLA 360

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 569001197 222 PHSIESFCLGHTEFVSRILVVPSHpELLLSSSGDGTLRLW 261
Cdd:COG2319  361 TGELLRTLTGHTGAVTSVAFSPDG-RTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
66-304 1.82e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 68.78  E-value: 1.82e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001197  66 LAFS------TTGSDDDCVFTYDCSTAEKKATPEDkgedgqpadtGSDSILASTFSKSGRYFALTDDSKRLILFRTKPWQ 139
Cdd:COG2319  168 VAFSpdgkllASGSDDGTVRLWDLATGKLLRTLTG----------HTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGK 237

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001197 140 CLSVRMV-VRRCTALTFTASEDRVLVADKSGDVYSFSVlEPDGCGRLELGHLSMLLDVAVSPDDQFVLTADRDEKIRVsW 218
Cdd:COG2319  238 LLRTLTGhSGSVRSVAFSPDGRLLASGSADGTVRLWDL-ATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRL-W 315

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001197 219 AAAPHSIESFCLGHTEFVSRILVVPShPELLLSSSGDGTLRLWeyrsgrqlqccDLAGLQEPGEQPGHKGlAASRIAFWG 298
Cdd:COG2319  316 DLATGKLLRTLTGHTGAVRSVAFSPD-GKTLASGSDDGTVRLW-----------DLATGELLRTLTGHTG-AVTSVAFSP 382


                 ....*.
gi 569001197 299 QESYVV 304
Cdd:COG2319  383 DGRTLA 388
WD40 COG2319
WD40 repeat [General function prediction only];
94-270 6.09e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 67.24  E-value: 6.09e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001197  94 DKGEDGQPADTGSDSILASTFSKSGRYFALTDDSKRLILFRTKPWQCL-SVRMVVRRCTALTFTASEDRVLVADKSGDVY 172
Cdd:COG2319  150 ATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLrTLTGHTGAVRSVAFSPDGKLLASGSADGTVR 229

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001197 173 SFSVlEPDGCGRLELGHLSMLLDVAVSPDDQFVLTADRDEKIRVsWAAAPHSIESFCLGHTEFVSRILVVPShPELLLSS 252
Cdd:COG2319  230 LWDL-ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRL-WDLATGELLRTLTGHSGGVNSVAFSPD-GKLLASG 306

                        170
                 ....*....|....*...
gi 569001197 253 SGDGTLRLWEYRSGRQLQ 270
Cdd:COG2319  307 SDDGTVRLWDLATGKLLR 324
WD40 COG2319
WD40 repeat [General function prediction only];
71-270 2.15e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 65.32  E-value: 2.15e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001197  71 TGSDDDCVFTYDCSTAEKKATPEDkgedgqpadtGSDSILASTFSKSGRYFALTDDSKRLILFRTKPWQCL-SVRMVVRR 149
Cdd:COG2319   95 SASADGTVRLWDLATGLLLRTLTG----------HTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLrTLTGHSGA 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001197 150 CTALTFTASEDRVLVADKSGDVYSFSVLEPDGCGRLElGHLSMLLDVAVSPDDQFVLTADRDEKIRVsWAAAPHSIESFC 229
Cdd:COG2319  165 VTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT-GHTGAVRSVAFSPDGKLLASGSADGTVRL-WDLATGKLLRTL 242

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 569001197 230 LGHTEFVSRILVVPSHpELLLSSSGDGTLRLWEYRSGRQLQ 270
Cdd:COG2319  243 TGHSGSVRSVAFSPDG-RLLASGSADGTVRLWDLATGELLR 282
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 188-270 1.51e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 61.97  E-value: 1.51e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001197 188 GHLSMLLDVAVSPDDQFVLTADRDEKIRVsWAAAPHSIESFCLGHTEFVSRILVVPSHpELLLSSSGDGTLRLWEYRSGR 267
Cdd:cd00200    7 GHTGGVTCVAFSPDGKLLATGSGDGTIKV-WDLETGELLRTLKGHTGPVRDVAASADG-TYLASGSSDKTIRLWDLETGE 84


                 ...
gi 569001197 268 QLQ 270
Cdd:cd00200   85 CVR 87
WD40 COG2319
WD40 repeat [General function prediction only];
114-270 6.75e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 60.70  E-value: 6.75e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001197 114 FSKSGRYFALTDDSKRLILFRTKPWQCLSVRMVVRRCTALTFTASEDRVLVADKSGDVYSFSVLEPDGCGRLELGHLSML 193
Cdd:COG2319    2 LSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAV 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 569001197 194 LDVAVSPDDQFVLTADRDEKIRVsWAAAPHSIESFCLGHTEFVSRILVVPSHpELLLSSSGDGTLRLWEYRSGRQLQ 270
Cdd:COG2319   82 LSVAFSPDGRLLASASADGTVRL-WDLATGLLLRTLTGHTGAVRSVAFSPDG-KTLASGSADGTVRLWDLATGKLLR 156
WD40 COG2319
WD40 repeat [General function prediction only];
105-270 6.61e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 57.61  E-value: 6.61e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001197 105 GSDSILASTFSKSGRYFALTDDSKRLILFRTKPWQCLSVRMVVR-RCTALTFTASEDRVLVADKSGDVYSFSVlEPDGCG 183
Cdd:COG2319   35 LAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTaAVLSVAFSPDGRLLASASADGTVRLWDL-ATGLLL 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001197 184 RLELGHLSMLLDVAVSPDDQFVLTADRDEKIRVsW-AAAPHSIESFcLGHTEFVSRILVVPSHpELLLSSSGDGTLRLWE 262
Cdd:COG2319  114 RTLTGHTGAVRSVAFSPDGKTLASGSADGTVRL-WdLATGKLLRTL-TGHSGAVTSVAFSPDG-KLLASGSDDGTVRLWD 190


                 ....*...
gi 569001197 263 YRSGRQLQ 270
Cdd:COG2319  191 LATGKLLR 198
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 151-262 8.68e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 47.33  E-value: 8.68e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001197 151 TALTFTASEDRVLVADKSGDVYSFSVLEPDGCGRLElGHLSMLLDVAVSPDDQFVLTADRDEKIRVsWAAAPHSIESFCL 230
Cdd:cd00200  181 NSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLR-GHENGVNSVAFSPDGYLLASGSEDGTIRV-WDLRTGECVQTLS 258

                         90       100       110
                 ....*....|....*....|....*....|..
gi 569001197 231 GHTEFVSRILVVPSHPeLLLSSSGDGTLRLWE 262
Cdd:cd00200  259 GHTNSVTSLAWSPDGK-RLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 56-219 1.35e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 43.48  E-value: 1.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001197  56 TLVVRGGSRFLAfstTGSDDDCVFTYDCSTAEKKATPEdkGEDGqpadtgsdSILASTFSKSGRYFALTDDSKRLILFRT 135
Cdd:cd00200  140 SVAFSPDGTFVA---SSSQDGTIKLWDLRTGKCVATLT--GHTG--------EVNSVAFSPDGEKLLSSSSDGTIKLWDL 206

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001197 136 KPWQCLSVRMVVR-RCTALTFTASEDRVLVADKSGDVYSFSVLEPDGCGRLElGHLSMLLDVAVSPDDQFVLTADRDEKI 214
Cdd:cd00200  207 STGKCLGTLRGHEnGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLS-GHTNSVTSLAWSPDGKRLASGSADGTI 285


                 ....*
gi 569001197 215 RVsWA 219
Cdd:cd00200  286 RI-WD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 231-262 8.03e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.21  E-value: 8.03e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 569001197   231 GHTEFVSRILVVPSHPeLLLSSSGDGTLRLWE 262
Cdd:smart00320  10 GHTGPVTSVAFSPDGK-YLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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