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Conserved domains on  [gi|568999895|ref|XP_006524146|]
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FLYWCH-type zinc finger-containing protein 1 isoform X1 [Mus musculus]

Protein Classification

FLYWCH_N and FLYWCH domain-containing protein( domain architecture ID 11011312)

protein containing domains FLYWCH_N, FLYWCH_u, and FLYWCH

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FLYWCH pfam04500
FLYWCH zinc finger domain; Mutations in the mod(mdg4) gene have effects on variegation (PEV), ...
 402-460 3.72e-16

FLYWCH zinc finger domain; Mutations in the mod(mdg4) gene have effects on variegation (PEV), the properties of insulator sequences, correct path-finding of growing nerve cells, meiotic pairing of chromosomes, and apoptosis. The occurrence of FLYWCH motifs in mod(mdg4) gene product and other proteins is discussed in.


:

Pssm-ID: 461332  Cd Length: 62  Bit Score: 73.15  E-value: 3.72e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568999895  402 FLKTPLGGNFLVYESFLYRREKVAGEKVYWTCRDQARMGCRSRAITQ--GRQVTVMR-SHCH 460
Cdd:pfam04500   1 FVRSRRGRPKLVINGYLYTRNKKSGGKIYWRCSQYRKIKCKARVVTDrgGTRVKVTRgEHNH 62
FLYWCH pfam04500
FLYWCH zinc finger domain; Mutations in the mod(mdg4) gene have effects on variegation (PEV), ...
 581-639 5.77e-16

FLYWCH zinc finger domain; Mutations in the mod(mdg4) gene have effects on variegation (PEV), the properties of insulator sequences, correct path-finding of growing nerve cells, meiotic pairing of chromosomes, and apoptosis. The occurrence of FLYWCH motifs in mod(mdg4) gene product and other proteins is discussed in.


:

Pssm-ID: 461332  Cd Length: 62  Bit Score: 72.38  E-value: 5.77e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568999895  581 FLRTSLGGRFLVYESFLYRKEKAAGEKVYWMCRDQARLGCRSRAITQ--GRRVMVMR-SHCH 639
Cdd:pfam04500   1 FVRSRRGRPKLVINGYLYTRNKKSGGKIYWRCSQYRKIKCKARVVTDrgGTRVKVTRgEHNH 62
FLYWCH pfam04500
FLYWCH zinc finger domain; Mutations in the mod(mdg4) gene have effects on variegation (PEV), ...
 235-293 8.20e-16

FLYWCH zinc finger domain; Mutations in the mod(mdg4) gene have effects on variegation (PEV), the properties of insulator sequences, correct path-finding of growing nerve cells, meiotic pairing of chromosomes, and apoptosis. The occurrence of FLYWCH motifs in mod(mdg4) gene product and other proteins is discussed in.


:

Pssm-ID: 461332  Cd Length: 62  Bit Score: 71.99  E-value: 8.20e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568999895  235 FLKTCYGGTFLVHQSFLYKREKTVGGKVYWTCREHAVHGCRSRAITQ--GQRVTVMR-SHCH 293
Cdd:pfam04500   1 FVRSRRGRPKLVINGYLYTRNKKSGGKIYWRCSQYRKIKCKARVVTDrgGTRVKVTRgEHNH 62
FLYWCH pfam04500
FLYWCH zinc finger domain; Mutations in the mod(mdg4) gene have effects on variegation (PEV), ...
 490-548 1.44e-15

FLYWCH zinc finger domain; Mutations in the mod(mdg4) gene have effects on variegation (PEV), the properties of insulator sequences, correct path-finding of growing nerve cells, meiotic pairing of chromosomes, and apoptosis. The occurrence of FLYWCH motifs in mod(mdg4) gene product and other proteins is discussed in.


:

Pssm-ID: 461332  Cd Length: 62  Bit Score: 71.22  E-value: 1.44e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568999895  490 FLKTPLGGSFLVYESFLYRREKATGDKVYWTCRDQARMGCRSRAITQ--GQRVMVMRR-HCH 548
Cdd:pfam04500   1 FVRSRRGRPKLVINGYLYTRNKKSGGKIYWRCSQYRKIKCKARVVTDrgGTRVKVTRGeHNH 62
FLYWCH_N super family cl21248
FLYWCH-type zinc finger-containing protein; This family is the N-terminus of some ...
 1-83 1.91e-14

FLYWCH-type zinc finger-containing protein; This family is the N-terminus of some FLYWCH-zinc-finger proteins, found in eukaryotes. The family is found in association with pfam04500. There are two conserved sequence motifs: EQE and QEPS.


The actual alignment was detected with superfamily member pfam15423:

Pssm-ID: 405997  Cd Length: 107  Bit Score: 69.87  E-value: 1.91e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568999895    1 MPLPEPSEQDCESLRAGQEPS---------VGARKPQESSNLV------PARDKERPKPTD---VASQETSSTATLPnNT 62
Cdd:pfam15423   1 MPLPEPSEQEGESVKAGQEPSpepgtdvvpAAPRKPREFSKLVlltasdQSGDGVDSKPKEvhcVMSLEMSGPATLA-ST 79

                          90       100
                  ....*....|....*....|....*...
gi 568999895   63 LQVAPVKKQGRIIHR-------KRSRVD 83
Cdd:pfam15423  80 LQILPAEEQGGAVQPapqapeqKRSKLD 107
FLYWCH_u super family cl25025
FLYWCH-type zinc finger-containing protein 1; FLYWCH_u is a region of natively unstructured ...
 294-351 1.84e-13

FLYWCH-type zinc finger-containing protein 1; FLYWCH_u is a region of natively unstructured but conserved sequence that lies between the FLYWCH zinc-finger domains on FLYWCH-type zinc finger-containing protein 1 proteins in higher eukaryotes. The function is not known but the N- and C-termini are likely to be part of the zinc-finger domains specific, to the eukaryotes.


The actual alignment was detected with superfamily member pfam16662:

Pssm-ID: 406949  Cd Length: 62  Bit Score: 65.23  E-value: 1.84e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 568999895  294 SPDIEGLQARRQQEKTIKKIQARRIGAGDLedcddiEDSLLQGVDSLFYRRGQGTLTL 351
Cdd:pfam16662   1 PPDMEGLEARRQQEKAMETLQARPGGPGGQ------ADKLLQGVDSLLYRRGPGTLTL 52
FLYWCH pfam04500
FLYWCH zinc finger domain; Mutations in the mod(mdg4) gene have effects on variegation (PEV), ...
 92-150 1.63e-12

FLYWCH zinc finger domain; Mutations in the mod(mdg4) gene have effects on variegation (PEV), the properties of insulator sequences, correct path-finding of growing nerve cells, meiotic pairing of chromosomes, and apoptosis. The occurrence of FLYWCH motifs in mod(mdg4) gene product and other proteins is discussed in.


:

Pssm-ID: 461332  Cd Length: 62  Bit Score: 62.75  E-value: 1.63e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568999895   92 FLKTPFGGRLLVHKSFLYKQEKAVGDKVYWKCRQHSELSCRGRAITR--GFRVTEMRD-HCH 150
Cdd:pfam04500   1 FVRSRRGRPKLVINGYLYTRNKKSGGKIYWRCSQYRKIKCKARVVTDrgGTRVKVTRGeHNH 62
 
Name Accession Description Interval E-value
FLYWCH pfam04500
FLYWCH zinc finger domain; Mutations in the mod(mdg4) gene have effects on variegation (PEV), ...
 402-460 3.72e-16

FLYWCH zinc finger domain; Mutations in the mod(mdg4) gene have effects on variegation (PEV), the properties of insulator sequences, correct path-finding of growing nerve cells, meiotic pairing of chromosomes, and apoptosis. The occurrence of FLYWCH motifs in mod(mdg4) gene product and other proteins is discussed in.


Pssm-ID: 461332  Cd Length: 62  Bit Score: 73.15  E-value: 3.72e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568999895  402 FLKTPLGGNFLVYESFLYRREKVAGEKVYWTCRDQARMGCRSRAITQ--GRQVTVMR-SHCH 460
Cdd:pfam04500   1 FVRSRRGRPKLVINGYLYTRNKKSGGKIYWRCSQYRKIKCKARVVTDrgGTRVKVTRgEHNH 62
FLYWCH pfam04500
FLYWCH zinc finger domain; Mutations in the mod(mdg4) gene have effects on variegation (PEV), ...
 581-639 5.77e-16

FLYWCH zinc finger domain; Mutations in the mod(mdg4) gene have effects on variegation (PEV), the properties of insulator sequences, correct path-finding of growing nerve cells, meiotic pairing of chromosomes, and apoptosis. The occurrence of FLYWCH motifs in mod(mdg4) gene product and other proteins is discussed in.


Pssm-ID: 461332  Cd Length: 62  Bit Score: 72.38  E-value: 5.77e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568999895  581 FLRTSLGGRFLVYESFLYRKEKAAGEKVYWMCRDQARLGCRSRAITQ--GRRVMVMR-SHCH 639
Cdd:pfam04500   1 FVRSRRGRPKLVINGYLYTRNKKSGGKIYWRCSQYRKIKCKARVVTDrgGTRVKVTRgEHNH 62
FLYWCH pfam04500
FLYWCH zinc finger domain; Mutations in the mod(mdg4) gene have effects on variegation (PEV), ...
 235-293 8.20e-16

FLYWCH zinc finger domain; Mutations in the mod(mdg4) gene have effects on variegation (PEV), the properties of insulator sequences, correct path-finding of growing nerve cells, meiotic pairing of chromosomes, and apoptosis. The occurrence of FLYWCH motifs in mod(mdg4) gene product and other proteins is discussed in.


Pssm-ID: 461332  Cd Length: 62  Bit Score: 71.99  E-value: 8.20e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568999895  235 FLKTCYGGTFLVHQSFLYKREKTVGGKVYWTCREHAVHGCRSRAITQ--GQRVTVMR-SHCH 293
Cdd:pfam04500   1 FVRSRRGRPKLVINGYLYTRNKKSGGKIYWRCSQYRKIKCKARVVTDrgGTRVKVTRgEHNH 62
FLYWCH pfam04500
FLYWCH zinc finger domain; Mutations in the mod(mdg4) gene have effects on variegation (PEV), ...
 490-548 1.44e-15

FLYWCH zinc finger domain; Mutations in the mod(mdg4) gene have effects on variegation (PEV), the properties of insulator sequences, correct path-finding of growing nerve cells, meiotic pairing of chromosomes, and apoptosis. The occurrence of FLYWCH motifs in mod(mdg4) gene product and other proteins is discussed in.


Pssm-ID: 461332  Cd Length: 62  Bit Score: 71.22  E-value: 1.44e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568999895  490 FLKTPLGGSFLVYESFLYRREKATGDKVYWTCRDQARMGCRSRAITQ--GQRVMVMRR-HCH 548
Cdd:pfam04500   1 FVRSRRGRPKLVINGYLYTRNKKSGGKIYWRCSQYRKIKCKARVVTDrgGTRVKVTRGeHNH 62
FLYWCH_N pfam15423
FLYWCH-type zinc finger-containing protein; This family is the N-terminus of some ...
 1-83 1.91e-14

FLYWCH-type zinc finger-containing protein; This family is the N-terminus of some FLYWCH-zinc-finger proteins, found in eukaryotes. The family is found in association with pfam04500. There are two conserved sequence motifs: EQE and QEPS.


Pssm-ID: 405997  Cd Length: 107  Bit Score: 69.87  E-value: 1.91e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568999895    1 MPLPEPSEQDCESLRAGQEPS---------VGARKPQESSNLV------PARDKERPKPTD---VASQETSSTATLPnNT 62
Cdd:pfam15423   1 MPLPEPSEQEGESVKAGQEPSpepgtdvvpAAPRKPREFSKLVlltasdQSGDGVDSKPKEvhcVMSLEMSGPATLA-ST 79

                          90       100
                  ....*....|....*....|....*...
gi 568999895   63 LQVAPVKKQGRIIHR-------KRSRVD 83
Cdd:pfam15423  80 LQILPAEEQGGAVQPapqapeqKRSKLD 107
FLYWCH_u pfam16662
FLYWCH-type zinc finger-containing protein 1; FLYWCH_u is a region of natively unstructured ...
 294-351 1.84e-13

FLYWCH-type zinc finger-containing protein 1; FLYWCH_u is a region of natively unstructured but conserved sequence that lies between the FLYWCH zinc-finger domains on FLYWCH-type zinc finger-containing protein 1 proteins in higher eukaryotes. The function is not known but the N- and C-termini are likely to be part of the zinc-finger domains specific, to the eukaryotes.


Pssm-ID: 406949  Cd Length: 62  Bit Score: 65.23  E-value: 1.84e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 568999895  294 SPDIEGLQARRQQEKTIKKIQARRIGAGDLedcddiEDSLLQGVDSLFYRRGQGTLTL 351
Cdd:pfam16662   1 PPDMEGLEARRQQEKAMETLQARPGGPGGQ------ADKLLQGVDSLLYRRGPGTLTL 52
FLYWCH pfam04500
FLYWCH zinc finger domain; Mutations in the mod(mdg4) gene have effects on variegation (PEV), ...
 92-150 1.63e-12

FLYWCH zinc finger domain; Mutations in the mod(mdg4) gene have effects on variegation (PEV), the properties of insulator sequences, correct path-finding of growing nerve cells, meiotic pairing of chromosomes, and apoptosis. The occurrence of FLYWCH motifs in mod(mdg4) gene product and other proteins is discussed in.


Pssm-ID: 461332  Cd Length: 62  Bit Score: 62.75  E-value: 1.63e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568999895   92 FLKTPFGGRLLVHKSFLYKQEKAVGDKVYWKCRQHSELSCRGRAITR--GFRVTEMRD-HCH 150
Cdd:pfam04500   1 FVRSRRGRPKLVINGYLYTRNKKSGGKIYWRCSQYRKIKCKARVVTDrgGTRVKVTRGeHNH 62
 
Name Accession Description Interval E-value
FLYWCH pfam04500
FLYWCH zinc finger domain; Mutations in the mod(mdg4) gene have effects on variegation (PEV), ...
 402-460 3.72e-16

FLYWCH zinc finger domain; Mutations in the mod(mdg4) gene have effects on variegation (PEV), the properties of insulator sequences, correct path-finding of growing nerve cells, meiotic pairing of chromosomes, and apoptosis. The occurrence of FLYWCH motifs in mod(mdg4) gene product and other proteins is discussed in.


Pssm-ID: 461332  Cd Length: 62  Bit Score: 73.15  E-value: 3.72e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568999895  402 FLKTPLGGNFLVYESFLYRREKVAGEKVYWTCRDQARMGCRSRAITQ--GRQVTVMR-SHCH 460
Cdd:pfam04500   1 FVRSRRGRPKLVINGYLYTRNKKSGGKIYWRCSQYRKIKCKARVVTDrgGTRVKVTRgEHNH 62
FLYWCH pfam04500
FLYWCH zinc finger domain; Mutations in the mod(mdg4) gene have effects on variegation (PEV), ...
 581-639 5.77e-16

FLYWCH zinc finger domain; Mutations in the mod(mdg4) gene have effects on variegation (PEV), the properties of insulator sequences, correct path-finding of growing nerve cells, meiotic pairing of chromosomes, and apoptosis. The occurrence of FLYWCH motifs in mod(mdg4) gene product and other proteins is discussed in.


Pssm-ID: 461332  Cd Length: 62  Bit Score: 72.38  E-value: 5.77e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568999895  581 FLRTSLGGRFLVYESFLYRKEKAAGEKVYWMCRDQARLGCRSRAITQ--GRRVMVMR-SHCH 639
Cdd:pfam04500   1 FVRSRRGRPKLVINGYLYTRNKKSGGKIYWRCSQYRKIKCKARVVTDrgGTRVKVTRgEHNH 62
FLYWCH pfam04500
FLYWCH zinc finger domain; Mutations in the mod(mdg4) gene have effects on variegation (PEV), ...
 235-293 8.20e-16

FLYWCH zinc finger domain; Mutations in the mod(mdg4) gene have effects on variegation (PEV), the properties of insulator sequences, correct path-finding of growing nerve cells, meiotic pairing of chromosomes, and apoptosis. The occurrence of FLYWCH motifs in mod(mdg4) gene product and other proteins is discussed in.


Pssm-ID: 461332  Cd Length: 62  Bit Score: 71.99  E-value: 8.20e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568999895  235 FLKTCYGGTFLVHQSFLYKREKTVGGKVYWTCREHAVHGCRSRAITQ--GQRVTVMR-SHCH 293
Cdd:pfam04500   1 FVRSRRGRPKLVINGYLYTRNKKSGGKIYWRCSQYRKIKCKARVVTDrgGTRVKVTRgEHNH 62
FLYWCH pfam04500
FLYWCH zinc finger domain; Mutations in the mod(mdg4) gene have effects on variegation (PEV), ...
 490-548 1.44e-15

FLYWCH zinc finger domain; Mutations in the mod(mdg4) gene have effects on variegation (PEV), the properties of insulator sequences, correct path-finding of growing nerve cells, meiotic pairing of chromosomes, and apoptosis. The occurrence of FLYWCH motifs in mod(mdg4) gene product and other proteins is discussed in.


Pssm-ID: 461332  Cd Length: 62  Bit Score: 71.22  E-value: 1.44e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568999895  490 FLKTPLGGSFLVYESFLYRREKATGDKVYWTCRDQARMGCRSRAITQ--GQRVMVMRR-HCH 548
Cdd:pfam04500   1 FVRSRRGRPKLVINGYLYTRNKKSGGKIYWRCSQYRKIKCKARVVTDrgGTRVKVTRGeHNH 62
FLYWCH_N pfam15423
FLYWCH-type zinc finger-containing protein; This family is the N-terminus of some ...
 1-83 1.91e-14

FLYWCH-type zinc finger-containing protein; This family is the N-terminus of some FLYWCH-zinc-finger proteins, found in eukaryotes. The family is found in association with pfam04500. There are two conserved sequence motifs: EQE and QEPS.


Pssm-ID: 405997  Cd Length: 107  Bit Score: 69.87  E-value: 1.91e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568999895    1 MPLPEPSEQDCESLRAGQEPS---------VGARKPQESSNLV------PARDKERPKPTD---VASQETSSTATLPnNT 62
Cdd:pfam15423   1 MPLPEPSEQEGESVKAGQEPSpepgtdvvpAAPRKPREFSKLVlltasdQSGDGVDSKPKEvhcVMSLEMSGPATLA-ST 79

                          90       100
                  ....*....|....*....|....*...
gi 568999895   63 LQVAPVKKQGRIIHR-------KRSRVD 83
Cdd:pfam15423  80 LQILPAEEQGGAVQPapqapeqKRSKLD 107
FLYWCH_u pfam16662
FLYWCH-type zinc finger-containing protein 1; FLYWCH_u is a region of natively unstructured ...
 294-351 1.84e-13

FLYWCH-type zinc finger-containing protein 1; FLYWCH_u is a region of natively unstructured but conserved sequence that lies between the FLYWCH zinc-finger domains on FLYWCH-type zinc finger-containing protein 1 proteins in higher eukaryotes. The function is not known but the N- and C-termini are likely to be part of the zinc-finger domains specific, to the eukaryotes.


Pssm-ID: 406949  Cd Length: 62  Bit Score: 65.23  E-value: 1.84e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 568999895  294 SPDIEGLQARRQQEKTIKKIQARRIGAGDLedcddiEDSLLQGVDSLFYRRGQGTLTL 351
Cdd:pfam16662   1 PPDMEGLEARRQQEKAMETLQARPGGPGGQ------ADKLLQGVDSLLYRRGPGTLTL 52
FLYWCH pfam04500
FLYWCH zinc finger domain; Mutations in the mod(mdg4) gene have effects on variegation (PEV), ...
 92-150 1.63e-12

FLYWCH zinc finger domain; Mutations in the mod(mdg4) gene have effects on variegation (PEV), the properties of insulator sequences, correct path-finding of growing nerve cells, meiotic pairing of chromosomes, and apoptosis. The occurrence of FLYWCH motifs in mod(mdg4) gene product and other proteins is discussed in.


Pssm-ID: 461332  Cd Length: 62  Bit Score: 62.75  E-value: 1.63e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568999895   92 FLKTPFGGRLLVHKSFLYKQEKAVGDKVYWKCRQHSELSCRGRAITR--GFRVTEMRD-HCH 150
Cdd:pfam04500   1 FVRSRRGRPKLVINGYLYTRNKKSGGKIYWRCSQYRKIKCKARVVTDrgGTRVKVTRGeHNH 62
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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