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Conserved domains on  [gi|568995222|ref|XP_006522139|]
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transforming growth factor beta activator LRRC33 isoform X1 [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
276-595 4.00e-17

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.21  E-value: 4.00e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 276 TLLLQDNNMGFYRELYNTSSPQEMVAQFLLVDGNVTNITTVNLWEEFSSSDLSALRFLDMSQNQFRHLPDGFLKKTPSLS 355
Cdd:COG4886   13 LLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 356 HLNLNQNCLKMLHIREHEPPGALTELDLSHNQLAELhlaPGLTGSLRNLRVFNLSSNQLLGVPTGLFdNASSITTIDMSH 435
Cdd:COG4886   93 GDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDL---PEELANLTNLKELDLSNNQLTDLPEPLG-NLTNLKSLDLSN 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 436 NQISLCPQmvpvdwegppscvDFRNMGSLRSLSLDGCGLKALQDCPFQGTSLTHLDLSSNwgvlngSISPLwavaptlqv 515
Cdd:COG4886  169 NQLTDLPE-------------ELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGN------QLTDL--------- 220

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 516 lslrdvglgsgaaEMDFSAFGNLRALDLSGNSLTSFPKFKGSLALRTLDLRRNSLTALPqrvvSEQPLRGLQTIYLSQNP 595
Cdd:COG4886  221 -------------PEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLP----PLANLTNLKTLDLSNNQ 283
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
106-414 4.41e-15

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.05  E-value: 4.41e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 106 HLRNLVLADNRLSEnykeSAAALHTLLGLRRLDLSGNSLTEDMAALmlQNLSSLEVVSLARNTLMRLDDSIfEGLEHLVE 185
Cdd:COG4886  114 NLESLDLSGNQLTD----LPEELANLTNLKELDLSNNQLTDLPEPL--GNLTNLKSLDLSNNQLTDLPEEL-GNLTNLKE 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 186 LDLQRNYIFEIeGGAFDGLTELRRLNLAYNN---LPCIVDfSLTQLRFLNVSYNILEWF--LAAREEvafeLEILDLSHN 260
Cdd:COG4886  187 LDLSNNQITDL-PEPLGNLTNLEELDLSGNQltdLPEPLA-NLTNLETLDLSNNQLTDLpeLGNLTN----LEELDLSNN 260

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 261 QLLFFPLLPQCGKLHTLLLQDNNMGFYRELYNTSSPQEMVAQFLLVDGNVTNITTVNLWEEFSSSDLSALRFLDMSQNQF 340
Cdd:COG4886  261 QLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTL 340

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568995222 341 RHLPDGFLKKTPSLSHLNLNQNCLKMLHIREHEPPGALTELDLSHNQLAELHLAPGLTGSLRNLRVFNLSSNQL 414
Cdd:COG4886  341 ALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVNTE 414
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
276-595 4.00e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.21  E-value: 4.00e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 276 TLLLQDNNMGFYRELYNTSSPQEMVAQFLLVDGNVTNITTVNLWEEFSSSDLSALRFLDMSQNQFRHLPDGFLKKTPSLS 355
Cdd:COG4886   13 LLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 356 HLNLNQNCLKMLHIREHEPPGALTELDLSHNQLAELhlaPGLTGSLRNLRVFNLSSNQLLGVPTGLFdNASSITTIDMSH 435
Cdd:COG4886   93 GDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDL---PEELANLTNLKELDLSNNQLTDLPEPLG-NLTNLKSLDLSN 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 436 NQISLCPQmvpvdwegppscvDFRNMGSLRSLSLDGCGLKALQDCPFQGTSLTHLDLSSNwgvlngSISPLwavaptlqv 515
Cdd:COG4886  169 NQLTDLPE-------------ELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGN------QLTDL--------- 220

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 516 lslrdvglgsgaaEMDFSAFGNLRALDLSGNSLTSFPKFKGSLALRTLDLRRNSLTALPqrvvSEQPLRGLQTIYLSQNP 595
Cdd:COG4886  221 -------------PEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLP----PLANLTNLKTLDLSNNQ 283
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
106-414 4.41e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.05  E-value: 4.41e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 106 HLRNLVLADNRLSEnykeSAAALHTLLGLRRLDLSGNSLTEDMAALmlQNLSSLEVVSLARNTLMRLDDSIfEGLEHLVE 185
Cdd:COG4886  114 NLESLDLSGNQLTD----LPEELANLTNLKELDLSNNQLTDLPEPL--GNLTNLKSLDLSNNQLTDLPEEL-GNLTNLKE 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 186 LDLQRNYIFEIeGGAFDGLTELRRLNLAYNN---LPCIVDfSLTQLRFLNVSYNILEWF--LAAREEvafeLEILDLSHN 260
Cdd:COG4886  187 LDLSNNQITDL-PEPLGNLTNLEELDLSGNQltdLPEPLA-NLTNLETLDLSNNQLTDLpeLGNLTN----LEELDLSNN 260

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 261 QLLFFPLLPQCGKLHTLLLQDNNMGFYRELYNTSSPQEMVAQFLLVDGNVTNITTVNLWEEFSSSDLSALRFLDMSQNQF 340
Cdd:COG4886  261 QLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTL 340

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568995222 341 RHLPDGFLKKTPSLSHLNLNQNCLKMLHIREHEPPGALTELDLSHNQLAELHLAPGLTGSLRNLRVFNLSSNQL 414
Cdd:COG4886  341 ALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVNTE 414
LRR_8 pfam13855
Leucine rich repeat;
157-217 2.63e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 56.38  E-value: 2.63e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568995222  157 SSLEVVSLARNTLMRLDDSIFEGLEHLVELDLQRNYIFEIEGGAFDGLTELRRLNLAYNNL 217
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 60-439 3.59e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 63.33  E-value: 3.59e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222  60 RMLILDANPLKDLWNHSLQAYPRLENLSLHSchlDRISHYAFREQGHLRNL---VLADNRLSenyKESAAALHTLLGLRR 136
Cdd:PLN00113 167 KVLDLGGNVLVGKIPNSLTNLTSLEFLTLAS---NQLVGQIPRELGQMKSLkwiYLGYNNLS---GEIPYEIGGLTSLNH 240

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 137 LDLSGNSLTEDMAAlMLQNLSSLEVVSLARNTLM-RLDDSIFeGLEHLVELDLQRNYIFEIEGGAFDGLTELRRLNLAYN 215
Cdd:PLN00113 241 LDLVYNNLTGPIPS-SLGNLKNLQYLFLYQNKLSgPIPPSIF-SLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSN 318

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 216 NL----PCIVDfSLTQLRFLNVSYNILEWFLAAREEVAFELEILDLSHN-----------------QLLFF--------- 265
Cdd:PLN00113 319 NFtgkiPVALT-SLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNnltgeipeglcssgnlfKLILFsnslegeip 397

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 266 PLLPQCGKLHTLLLQDNNmgFYRELYNTSSPQEMVAQFLLVDGNVTNITTVNLWeefsssDLSALRFLDMSQNQFR-HLP 344
Cdd:PLN00113 398 KSLGACRSLRRVRLQDNS--FSGELPSEFTKLPLVYFLDISNNNLQGRINSRKW------DMPSLQMLSLARNKFFgGLP 469

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 345 DGFlkKTPSLSHLNLNQNCLKMLHIREHEPPGALTELDLSHNQLAelHLAPGLTGSLRNLRVFNLSSNQLLGVPTGLFDN 424
Cdd:PLN00113 470 DSF--GSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLS--GEIPDELSSCKKLVSLDLSHNQLSGQIPASFSE 545

                        410
                 ....*....|....*
gi 568995222 425 ASSITTIDMSHNQIS 439
Cdd:PLN00113 546 MPVLSQLDLSQNQLS 560
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 137-371 9.65e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 59.03  E-value: 9.65e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 137 LDLSGNSLTEdmaalmLQNLS---SLEVVSLARNTLMRLDDsiFEGLEHLVELDLQRNYIFEIEGgaFDGLTELRRLNLA 213
Cdd:cd21340    7 LYLNDKNITK------IDNLSlckNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLG 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 214 YNNLPCIVDF-SLTQLRFLNVSYNIlewfLAAREEVAFELEILD-LSHNqllffpllpqcgkLHTLLLQDNNMGFYRELY 291
Cdd:cd21340   77 GNRISVVEGLeNLTNLEELHIENQR----LPPGEKLTFDPRSLAaLSNS-------------LRVLNISGNNIDSLEPLA 139

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 292 NtsspqemvaqfllvdgnvtnittvnlweefsssdLSALRFLDMSQNQFRHLPD--GFLKKTPSLSHLNLNQNCL-KMLH 368
Cdd:cd21340  140 P----------------------------------LRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVcKKPK 185


                 ...
gi 568995222 369 IRE 371
Cdd:cd21340  186 YRD 188
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 309-638 2.32e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 60.63  E-value: 2.32e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 309 NVTNITTVNLWEEFSSSDLSALRF-------LDMSQNQFR-HLPDGFLKKTPSLSHLNLNQNCLKMLHIREHEPpgALTE 380
Cdd:PLN00113  67 NSSRVVSIDLSGKNISGKISSAIFrlpyiqtINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFTGSIPRGSIP--NLET 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 381 LDLSHNQLA-ELhlaPGLTGSLRNLRVFNLSSNQLLGVPTGLFDNASSITTIDMSHNQISlcpQMVPvdwegppscvdfR 459
Cdd:PLN00113 145 LDLSNNMLSgEI---PNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLV---GQIP------------R 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 460 NMGSLRSLSLDGCGLKALQ-DCPFQ---GTSLTHLDLSSNwgVLNGSISPLWAVAPTLQVLSLRDVGLgSGAAEMDFSAF 535
Cdd:PLN00113 207 ELGQMKSLKWIYLGYNNLSgEIPYEiggLTSLNHLDLVYN--NLTGPIPSSLGNLKNLQYLFLYQNKL-SGPIPPSIFSL 283

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 536 GNLRALDLSGNSLT-SFPKFKGSL-ALRTLDLRRNSLTALPQRVVSEQPLrgLQTIYLSQNPYDCCGVEGWGalQQHFKT 613
Cdd:PLN00113 284 QKLISLDLSDNSLSgEIPELVIQLqNLEILHLFSNNFTGKIPVALTSLPR--LQVLQLWSNKFSGEIPKNLG--KHNNLT 359

                        330       340
                 ....*....|....*....|....*
gi 568995222 614 VADLSmvTCNLSSKIvrvvelPEGL 638
Cdd:PLN00113 360 VLDLS--TNNLTGEI------PEGL 376
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 333-564 8.35e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.55  E-value: 8.35e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 333 LDMSQNQFRHLPDgfLKKTPSLSHLNLNQNCLKmlHIREHEPPGALTELDLSHNQLAELhlaPGLtGSLRNLRVFNLSSN 412
Cdd:cd21340    7 LYLNDKNITKIDN--LSLCKNLKVLYLYDNKIT--KIENLEFLTNLTHLYLQNNQIEKI---ENL-ENLVNLKKLYLGGN 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 413 QLlGVPTGLfDNASSITTIDMSHNQISlcpqmvpvdwEGPPSCVDFRNM----GSLRSLSLDGCGLKALQdcPFQG-TSL 487
Cdd:cd21340   79 RI-SVVEGL-ENLTNLEELHIENQRLP----------PGEKLTFDPRSLaalsNSLRVLNISGNNIDSLE--PLAPlRNL 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 488 THLDLSSNwgvlngsisplwavaptlQVLSLRDVglgsgaaEMDFSAFGNLRALDLSGNSLTSFPKFK-----GSLALRT 562
Cdd:cd21340  145 EQLDASNN------------------QISDLEEL-------LDLLSSWPSLRELDLTGNPVCKKPKYRdkiilASKSLEV 199


                 ..
gi 568995222 563 LD 564
Cdd:cd21340  200 LD 201
LRR_8 pfam13855
Leucine rich repeat;
378-438 2.28e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.21  E-value: 2.28e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568995222  378 LTELDLSHNQLaeLHLAPGLTGSLRNLRVFNLSSNQLLGVPTGLFDNASSITTIDMSHNQI 438
Cdd:pfam13855   3 LRSLDLSNNRL--TSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
276-595 4.00e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.21  E-value: 4.00e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 276 TLLLQDNNMGFYRELYNTSSPQEMVAQFLLVDGNVTNITTVNLWEEFSSSDLSALRFLDMSQNQFRHLPDGFLKKTPSLS 355
Cdd:COG4886   13 LLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 356 HLNLNQNCLKMLHIREHEPPGALTELDLSHNQLAELhlaPGLTGSLRNLRVFNLSSNQLLGVPTGLFdNASSITTIDMSH 435
Cdd:COG4886   93 GDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDL---PEELANLTNLKELDLSNNQLTDLPEPLG-NLTNLKSLDLSN 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 436 NQISLCPQmvpvdwegppscvDFRNMGSLRSLSLDGCGLKALQDCPFQGTSLTHLDLSSNwgvlngSISPLwavaptlqv 515
Cdd:COG4886  169 NQLTDLPE-------------ELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGN------QLTDL--------- 220

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 516 lslrdvglgsgaaEMDFSAFGNLRALDLSGNSLTSFPKFKGSLALRTLDLRRNSLTALPqrvvSEQPLRGLQTIYLSQNP 595
Cdd:COG4886  221 -------------PEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLP----PLANLTNLKTLDLSNNQ 283
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
107-449 1.40e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 82.67  E-value: 1.40e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 107 LRNLVLADNRLSENYKESAAALHTLLGLRRLDLSGNSLtedmaalmLQNLSSLEVVSLARNTLMRLDDSIfEGLEHLVEL 186
Cdd:COG4886   71 LLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEE--------LSNLTNLESLDLSGNQLTDLPEEL-ANLTNLKEL 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 187 DLQRNYIFEIeGGAFDGLTELRRLNLAYNNLPCIVDF--SLTQLRFLNVSYN---ILEWFLAAREEvafeLEILDLSHNQ 261
Cdd:COG4886  142 DLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPEElgNLTNLKELDLSNNqitDLPEPLGNLTN----LEELDLSGNQ 216

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 262 LLFFPL-LPQCGKLHTLLLQDNNmgfyrelyntsspqemvaqfllvdgnVTNITTVnlweefssSDLSALRFLDMSQNQF 340
Cdd:COG4886  217 LTDLPEpLANLTNLETLDLSNNQ--------------------------LTDLPEL--------GNLTNLEELDLSNNQL 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 341 RHLPDgfLKKTPSLSHLNLNQNCLKMLHIREHEPPGALTELDLSHNQLAELHLAPGLTGSLRNLRVFNLSSNQLLGVPTG 420
Cdd:COG4886  263 TDLPP--LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTL 340

                        330       340
                 ....*....|....*....|....*....
gi 568995222 421 LFDNASSITTIDMSHNQISLCPQMVPVDW 449
Cdd:COG4886  341 ALSLSLLALLTLLLLLNLLSLLLTLLLTL 369
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
210-594 5.88e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 80.75  E-value: 5.88e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 210 LNLAYNNLPCIVDFSLTQLRFLNVSYNILEWFLAAREEVAFELEILDLSHNQLLFFPLLPQCGKLHTLLLQDNNMGFYRE 289
Cdd:COG4886    3 LLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 290 LYNTSSPQEMvaqfllvdGNVTNITTVNLWEEFSSSDLSALRFLDMSQNQFRHLPDgflkktpSLSHLNlnqnclkmlhi 369
Cdd:COG4886   83 SLLLLGLTDL--------GDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPE-------ELANLT----------- 136

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 370 reheppgALTELDLSHNQLAELhlaPGLTGSLRNLRVFNLSSNQLLGVPTGLfDNASSITTIDMSHNQISlcpqmvpvdw 449
Cdd:COG4886  137 -------NLKELDLSNNQLTDL---PEPLGNLTNLKSLDLSNNQLTDLPEEL-GNLTNLKELDLSNNQIT---------- 195

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 450 EGPPScvdFRNMGSLRSLSLDGCGLKALQDCPFQGTSLTHLDLSSNwgvlngSISPLwavaPTLQVLSlrdvglgsgaae 529
Cdd:COG4886  196 DLPEP---LGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNN------QLTDL----PELGNLT------------ 250

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568995222 530 mdfsafgNLRALDLSGNSLTSFPKFKGSLALRTLDLRRNSLTALPQRVVSEQPLRGLQTIYLSQN 594
Cdd:COG4886  251 -------NLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLL 308
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
106-414 4.41e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.05  E-value: 4.41e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 106 HLRNLVLADNRLSEnykeSAAALHTLLGLRRLDLSGNSLTEDMAALmlQNLSSLEVVSLARNTLMRLDDSIfEGLEHLVE 185
Cdd:COG4886  114 NLESLDLSGNQLTD----LPEELANLTNLKELDLSNNQLTDLPEPL--GNLTNLKSLDLSNNQLTDLPEEL-GNLTNLKE 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 186 LDLQRNYIFEIeGGAFDGLTELRRLNLAYNN---LPCIVDfSLTQLRFLNVSYNILEWF--LAAREEvafeLEILDLSHN 260
Cdd:COG4886  187 LDLSNNQITDL-PEPLGNLTNLEELDLSGNQltdLPEPLA-NLTNLETLDLSNNQLTDLpeLGNLTN----LEELDLSNN 260

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 261 QLLFFPLLPQCGKLHTLLLQDNNMGFYRELYNTSSPQEMVAQFLLVDGNVTNITTVNLWEEFSSSDLSALRFLDMSQNQF 340
Cdd:COG4886  261 QLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTL 340

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568995222 341 RHLPDGFLKKTPSLSHLNLNQNCLKMLHIREHEPPGALTELDLSHNQLAELHLAPGLTGSLRNLRVFNLSSNQL 414
Cdd:COG4886  341 ALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVNTE 414
LRR_8 pfam13855
Leucine rich repeat;
157-217 2.63e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 56.38  E-value: 2.63e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568995222  157 SSLEVVSLARNTLMRLDDSIFEGLEHLVELDLQRNYIFEIEGGAFDGLTELRRLNLAYNNL 217
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 60-439 3.59e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 63.33  E-value: 3.59e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222  60 RMLILDANPLKDLWNHSLQAYPRLENLSLHSchlDRISHYAFREQGHLRNL---VLADNRLSenyKESAAALHTLLGLRR 136
Cdd:PLN00113 167 KVLDLGGNVLVGKIPNSLTNLTSLEFLTLAS---NQLVGQIPRELGQMKSLkwiYLGYNNLS---GEIPYEIGGLTSLNH 240

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 137 LDLSGNSLTEDMAAlMLQNLSSLEVVSLARNTLM-RLDDSIFeGLEHLVELDLQRNYIFEIEGGAFDGLTELRRLNLAYN 215
Cdd:PLN00113 241 LDLVYNNLTGPIPS-SLGNLKNLQYLFLYQNKLSgPIPPSIF-SLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSN 318

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 216 NL----PCIVDfSLTQLRFLNVSYNILEWFLAAREEVAFELEILDLSHN-----------------QLLFF--------- 265
Cdd:PLN00113 319 NFtgkiPVALT-SLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNnltgeipeglcssgnlfKLILFsnslegeip 397

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 266 PLLPQCGKLHTLLLQDNNmgFYRELYNTSSPQEMVAQFLLVDGNVTNITTVNLWeefsssDLSALRFLDMSQNQFR-HLP 344
Cdd:PLN00113 398 KSLGACRSLRRVRLQDNS--FSGELPSEFTKLPLVYFLDISNNNLQGRINSRKW------DMPSLQMLSLARNKFFgGLP 469

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 345 DGFlkKTPSLSHLNLNQNCLKMLHIREHEPPGALTELDLSHNQLAelHLAPGLTGSLRNLRVFNLSSNQLLGVPTGLFDN 424
Cdd:PLN00113 470 DSF--GSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLS--GEIPDELSSCKKLVSLDLSHNQLSGQIPASFSE 545

                        410
                 ....*....|....*
gi 568995222 425 ASSITTIDMSHNQIS 439
Cdd:PLN00113 546 MPVLSQLDLSQNQLS 560
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 137-371 9.65e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 59.03  E-value: 9.65e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 137 LDLSGNSLTEdmaalmLQNLS---SLEVVSLARNTLMRLDDsiFEGLEHLVELDLQRNYIFEIEGgaFDGLTELRRLNLA 213
Cdd:cd21340    7 LYLNDKNITK------IDNLSlckNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLG 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 214 YNNLPCIVDF-SLTQLRFLNVSYNIlewfLAAREEVAFELEILD-LSHNqllffpllpqcgkLHTLLLQDNNMGFYRELY 291
Cdd:cd21340   77 GNRISVVEGLeNLTNLEELHIENQR----LPPGEKLTFDPRSLAaLSNS-------------LRVLNISGNNIDSLEPLA 139

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 292 NtsspqemvaqfllvdgnvtnittvnlweefsssdLSALRFLDMSQNQFRHLPD--GFLKKTPSLSHLNLNQNCL-KMLH 368
Cdd:cd21340  140 P----------------------------------LRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVcKKPK 185


                 ...
gi 568995222 369 IRE 371
Cdd:cd21340  186 YRD 188
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 309-638 2.32e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 60.63  E-value: 2.32e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 309 NVTNITTVNLWEEFSSSDLSALRF-------LDMSQNQFR-HLPDGFLKKTPSLSHLNLNQNCLKMLHIREHEPpgALTE 380
Cdd:PLN00113  67 NSSRVVSIDLSGKNISGKISSAIFrlpyiqtINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFTGSIPRGSIP--NLET 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 381 LDLSHNQLA-ELhlaPGLTGSLRNLRVFNLSSNQLLGVPTGLFDNASSITTIDMSHNQISlcpQMVPvdwegppscvdfR 459
Cdd:PLN00113 145 LDLSNNMLSgEI---PNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLV---GQIP------------R 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 460 NMGSLRSLSLDGCGLKALQ-DCPFQ---GTSLTHLDLSSNwgVLNGSISPLWAVAPTLQVLSLRDVGLgSGAAEMDFSAF 535
Cdd:PLN00113 207 ELGQMKSLKWIYLGYNNLSgEIPYEiggLTSLNHLDLVYN--NLTGPIPSSLGNLKNLQYLFLYQNKL-SGPIPPSIFSL 283

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 536 GNLRALDLSGNSLT-SFPKFKGSL-ALRTLDLRRNSLTALPQRVVSEQPLrgLQTIYLSQNPYDCCGVEGWGalQQHFKT 613
Cdd:PLN00113 284 QKLISLDLSDNSLSgEIPELVIQLqNLEILHLFSNNFTGKIPVALTSLPR--LQVLQLWSNKFSGEIPKNLG--KHNNLT 359

                        330       340
                 ....*....|....*....|....*
gi 568995222 614 VADLSmvTCNLSSKIvrvvelPEGL 638
Cdd:PLN00113 360 VLDLS--TNNLTGEI------PEGL 376
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 155-594 2.61e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 60.63  E-value: 2.61e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 155 NLSSLEVVSLA-RNTLMRLDDSIFeGLEHLVELDLQRNYI-FEIEGGAFDGLTELRRLNLAYNNLP-CIVDFSLTQLRFL 231
Cdd:PLN00113  67 NSSRVVSIDLSgKNISGKISSAIF-RLPYIQTINLSNNQLsGPIPDDIFTTSSSLRYLNLSNNNFTgSIPRGSIPNLETL 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 232 NVSYNILEWFLAAREEVAFELEILDLSHNQLL--FFPLLPQCGKLHTLLLQDNNM--GFYREL------------YNTSS 295
Cdd:PLN00113 146 DLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVgkIPNSLTNLTSLEFLTLASNQLvgQIPRELgqmkslkwiylgYNNLS 225

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 296 ---PQEMVAqflLVDGNVTNITTVNLWEEFSSS--DLSALRFLDMSQNQFR-HLPDGFLKKTPSLShLNLNQNCLKmlhi 369
Cdd:PLN00113 226 geiPYEIGG---LTSLNHLDLVYNNLTGPIPSSlgNLKNLQYLFLYQNKLSgPIPPSIFSLQKLIS-LDLSDNSLS---- 297

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 370 reheppGALTELDLSHNQLAELHL--------APGLTGSLRNLRVFNLSSNQLLG-VPTGLfDNASSITTIDMSHNQIS- 439
Cdd:PLN00113 298 ------GEIPELVIQLQNLEILHLfsnnftgkIPVALTSLPRLQVLQLWSNKFSGeIPKNL-GKHNNLTVLDLSTNNLTg 370

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 440 -----LCPQ---------MVPVDWEGPPSCVDFRnmgSLRSLSLDGCGLKALQDCPFQGTSLTH-LDLSSNwgVLNGSIS 504
Cdd:PLN00113 371 eipegLCSSgnlfklilfSNSLEGEIPKSLGACR---SLRRVRLQDNSFSGELPSEFTKLPLVYfLDISNN--NLQGRIN 445

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 505 PLWAVAPTLQVLSL-RDVGLG---------------------SGAAEMDFSAFGNLRALDLSGNSLTS-FPKFKGSLA-L 560
Cdd:PLN00113 446 SRKWDMPSLQMLSLaRNKFFGglpdsfgskrlenldlsrnqfSGAVPRKLGSLSELMQLKLSENKLSGeIPDELSSCKkL 525

                        490       500       510
                 ....*....|....*....|....*....|....
gi 568995222 561 RTLDLRRNSLTALPQRVVSEQPLrgLQTIYLSQN 594
Cdd:PLN00113 526 VSLDLSHNQLSGQIPASFSEMPV--LSQLDLSQN 557
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
42-321 2.77e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 59.95  E-value: 2.77e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222  42 DCRGLNLASVPSSLP--PHSRMLILDANPLKDLwNHSLQAYPRLENLSLHSCHLDRISHyAFREQGHLRNLVLADNRLSE 119
Cdd:COG4886  142 DLSNNQLTDLPEPLGnlTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTD 219

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 120 NykesAAALHTLLGLRRLDLSGNSLTEdmaALMLQNLSSLEVVSLARNTLMRLDDSifEGLEHLVELDLQRNYIFEIEGG 199
Cdd:COG4886  220 L----PEPLANLTNLETLDLSNNQLTD---LPELGNLTNLEELDLSNNQLTDLPPL--ANLTNLKTLDLSNNQLTDLKLK 290

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 200 AFDGLTELRRLNLAYNNLPCIVDFSLTQLrFLNVSYNILEWFLAAREEVAFELEILDLSHNQLLFFPLLPQCGKLHTLLL 279
Cdd:COG4886  291 ELELLLGLNSLLLLLLLLNLLELLILLLL-LTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTL 369

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 568995222 280 QDNNMGFYRELYNTSSPQEMVAQFLLVDGNVTNITTVNLWEE 321
Cdd:COG4886  370 GLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAV 411
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
358-575 1.00e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 58.55  E-value: 1.00e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 358 NLNQNCLKMLHIRE--HEPPGALTELDLSHNQLaeLHLAPGLTGSLRNLRVfnlSSNQLLGVPTGLFDN----------- 424
Cdd:PRK15370 179 NKTELRLKILGLTTipACIPEQITTLILDNNEL--KSLPENLQGNIKTLYA---NSNQLTSIPATLPDTiqemelsinri 253

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 425 -------ASSITTIDMSHNQISLCPQMVPvdwEGppscvdfrnmgsLRSLSLDGCGLKAL-QDCPfqgTSLTHLDLSSNw 496
Cdd:PRK15370 254 telperlPSALQSLDLFHNKISCLPENLP---EE------------LRYLSVYDNSIRTLpAHLP---SGITHLNVQSN- 314

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 497 gvlngSISPLWAVAP-TLQVLSLRDVGLGSGAAEMDfsafGNLRALDLSGNSLTSFPKfkgSL--ALRTLDLRRNSLTAL 573
Cdd:PRK15370 315 -----SLTALPETLPpGLKTLEAGENALTSLPASLP----PELQVLDVSKNQITVLPE---TLppTITTLDVSRNALTNL 382


                 ..
gi 568995222 574 PQ 575
Cdd:PRK15370 383 PE 384
LRR_8 pfam13855
Leucine rich repeat;
182-236 1.35e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.67  E-value: 1.35e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 568995222  182 HLVELDLQRNYIFEIEGGAFDGLTELRRLNLAYNNLPCIVD---FSLTQLRFLNVSYN 236
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPgafSGLPSLRYLDLSGN 59
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
251-446 2.94e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 53.93  E-value: 2.94e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 251 ELEILDLSHNQLLFFPLLPQcGKLHTLLLQDNNMgfyrelynTSSPQEMVAQFLLVDGNVTNITtvnlweEFSSSDLSAL 330
Cdd:PRK15370 200 QITTLILDNNELKSLPENLQ-GNIKTLYANSNQL--------TSIPATLPDTIQEMELSINRIT------ELPERLPSAL 264

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 331 RFLDMSQNQFRHLPDGFlkkTPSLSHLNLNQNCLKMLhiREHEPPGaLTELDLSHNQLAEL--HLAPGLT---------- 398
Cdd:PRK15370 265 QSLDLFHNKISCLPENL---PEELRYLSVYDNSIRTL--PAHLPSG-ITHLNVQSNSLTALpeTLPPGLKtleagenalt 338

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 568995222 399 ---GSLR-NLRVFNLSSNQLLGVPTGLfdnASSITTIDMSHNQISLCPQMVP 446
Cdd:PRK15370 339 slpASLPpELQVLDVSKNQITVLPETL---PPTITTLDVSRNALTNLPENLP 387
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 333-564 8.35e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.55  E-value: 8.35e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 333 LDMSQNQFRHLPDgfLKKTPSLSHLNLNQNCLKmlHIREHEPPGALTELDLSHNQLAELhlaPGLtGSLRNLRVFNLSSN 412
Cdd:cd21340    7 LYLNDKNITKIDN--LSLCKNLKVLYLYDNKIT--KIENLEFLTNLTHLYLQNNQIEKI---ENL-ENLVNLKKLYLGGN 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 413 QLlGVPTGLfDNASSITTIDMSHNQISlcpqmvpvdwEGPPSCVDFRNM----GSLRSLSLDGCGLKALQdcPFQG-TSL 487
Cdd:cd21340   79 RI-SVVEGL-ENLTNLEELHIENQRLP----------PGEKLTFDPRSLaalsNSLRVLNISGNNIDSLE--PLAPlRNL 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 488 THLDLSSNwgvlngsisplwavaptlQVLSLRDVglgsgaaEMDFSAFGNLRALDLSGNSLTSFPKFK-----GSLALRT 562
Cdd:cd21340  145 EQLDASNN------------------QISDLEEL-------LDLLSSWPSLRELDLTGNPVCKKPKYRdkiilASKSLEV 199


                 ..
gi 568995222 563 LD 564
Cdd:cd21340  200 LD 201
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
18-362 1.19e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 52.01  E-value: 1.19e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222  18 EW-RSGPGTATAASQggcKVVDGVADC----------RGLNLASVPSSLPPHSRMLILDANPLKDLwnhslqayPrlENL 86
Cdd:PRK15370 152 EWvKEAPAKEAANRE---EAVQRMRDClknnktelrlKILGLTTIPACIPEQITTLILDNNELKSL--------P--ENL 218

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222  87 slhschldrishyafreQGHLRNLVLADN---RLSENYKESaaalhtllgLRRLDLSGNSLTEdmaalMLQNL-SSLEVV 162
Cdd:PRK15370 219 -----------------QGNIKTLYANSNqltSIPATLPDT---------IQEMELSINRITE-----LPERLpSALQSL 267

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 163 SLARNTLMRLDDSIFEGLEHlveLDLQRNYIFEIEGGAFDGLTELRRLNLAYNNLPCIVDFSltqLRFLNVSYNILEwfl 242
Cdd:PRK15370 268 DLFHNKISCLPENLPEELRY---LSVYDNSIRTLPAHLPSGITHLNVQSNSLTALPETLPPG---LKTLEAGENALT--- 338

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 243 AAREEVAFELEILDLSHNQLLFFPllpqcgklhtlllqdnnmgfyrelyNTSSPqemVAQFLLVDGNVtnitTVNLWEEF 322
Cdd:PRK15370 339 SLPASLPPELQVLDVSKNQITVLP-------------------------ETLPP---TITTLDVSRNA----LTNLPENL 386

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 568995222 323 SssdlSALRFLDMSQNQFRHLPDG---FLKKTPSLSHLNLNQN 362
Cdd:PRK15370 387 P----AALQIMQASRNNLVRLPESlphFRGEGPQPTRIIVEYN 425
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 357-602 1.82e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 50.43  E-value: 1.82e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 357 LNLNQNCLKMLHIREHEPP-GALTELDLSHNQLAELHlAPGLTGSLR---NLRVFNLSSNQLLGVPTGL------FDNAS 426
Cdd:cd00116    3 LSLKGELLKTERATELLPKlLCLQVLRLEGNTLGEEA-AKALASALRpqpSLKELCLSLNETGRIPRGLqsllqgLTKGC 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 427 SITTIDMSHNqiSLCPqmvpvdwEGPPSCVDFRNMGSLRSLSLDGCGL---------KALQDCPfqgTSLTHLDLSSNwG 497
Cdd:cd00116   82 GLQELDLSDN--ALGP-------DGCGVLESLLRSSSLQELKLNNNGLgdrglrllaKGLKDLP---PALEKLVLGRN-R 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 498 VLNGSISPLWAVAP---TLQVLSLRDVGLGSGAAEM---DFSAFGNLRALDLSGNSLTSF------PKFKGSLALRTLDL 565
Cdd:cd00116  149 LEGASCEALAKALRanrDLKELNLANNGIGDAGIRAlaeGLKANCNLEVLDLNNNGLTDEgasalaETLASLKSLEVLNL 228

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 568995222 566 RRNSLTALPQRVVSEQ---PLRGLQTIYLSQNPYDCCGVE 602
Cdd:cd00116  229 GDNNLTDAGAAALASAllsPNISLLTLSLSCNDITDDGAK 268
LRR_8 pfam13855
Leucine rich repeat;
378-438 2.28e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.21  E-value: 2.28e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568995222  378 LTELDLSHNQLaeLHLAPGLTGSLRNLRVFNLSSNQLLGVPTGLFDNASSITTIDMSHNQI 438
Cdd:pfam13855   3 LRSLDLSNNRL--TSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
375-595 5.70e-06

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 49.78  E-value: 5.70e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 375 PGALTELDLSHNQLAELhlaPGLTGSLRNLRVFNLSSNQLLGVPTGLfdnassiTTIDMSHNQISLCPQMVPVDWEgppS 454
Cdd:PRK15387 241 PPELRTLEVSGNQLTSL---PVLPPGLLELSIFSNPLTHLPALPSGL-------CKLWIFGNQLTSLPVLPPGLQE---L 307

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 455 CVDFRNMGSLRSLSLDGCGLKA----LQDCPFQGTSLTHLDLSSN----WGVLNGSISPLWAVAPTLQVLSlrdvGLGSG 526
Cdd:PRK15387 308 SVSDNQLASLPALPSELCKLWAynnqLTSLPTLPSGLQELSVSDNqlasLPTLPSELYKLWAYNNRLTSLP----ALPSG 383

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 527 AAEMDFSafGN-----------LRALDLSGNSLTSFPKFKGSLAlrTLDLRRNSLTALPQRVVSeqpLRGLQTIYLSQNP 595
Cdd:PRK15387 384 LKELIVS--GNrltslpvlpseLKELMVSGNRLTSLPMLPSGLL--SLSVYRNQLTRLPESLIH---LSSETTVNLEGNP 456
LRR_8 pfam13855
Leucine rich repeat;
133-193 1.96e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.51  E-value: 1.96e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568995222  133 GLRRLDLSGNSLTeDMAALMLQNLSSLEVVSLARNTLMRLDDSIFEGLEHLVELDLQRNYI 193
Cdd:pfam13855   2 NLRSLDLSNNRLT-SLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
330-388 2.65e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.13  E-value: 2.65e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 568995222  330 LRFLDMSQNQFRHLPDGFLKKTPSLSHLNLNQNCLKMLHIREHEPPGALTELDLSHNQL 388
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
537-595 3.20e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.13  E-value: 3.20e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568995222  537 NLRALDLSGNSLTSFPK--FKGSLALRTLDLRRNSLTALPQRVVSeqPLRGLQTIYLSQNP 595
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLSPGAFS--GLPSLRYLDLSGNR 60
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 378-574 7.55e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 44.39  E-value: 7.55e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 378 LTELDLSHNQLAELhlapGLTGSLRNLRVFNLSSNQLLGVPTglFDNASSITTIDMSHNQISlcpqmvpvdwegppSCVD 457
Cdd:cd21340    4 ITHLYLNDKNITKI----DNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIE--------------KIEN 63

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 458 FRNMGSLRSLSLDG---CGLKALQDCpfqgTSLTHLDLSsnwgvlNGSISP----------LWAVAPTLQVLSLRDVGLG 524
Cdd:cd21340   64 LENLVNLKKLYLGGnriSVVEGLENL----TNLEELHIE------NQRLPPgekltfdprsLAALSNSLRVLNISGNNID 133

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 568995222 525 SGAaemDFSAFGNLRALDLSGNSLTSFPKFKGSLA----LRTLDLRRNSLTALP 574
Cdd:cd21340  134 SLE---PLAPLRNLEQLDASNNQISDLEELLDLLSswpsLRELDLTGNPVCKKP 184
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 369-627 9.37e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 45.55  E-value: 9.37e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 369 IREHEPPGALTELDLShNQLAELHLAPGLTGSLRNLRVFNLSSNQLLGVPTGLFDNasSITTIDMSHNQISLCpqmvpvd 448
Cdd:COG5238  126 TLEDSLILYLALPRRI-NLIQVLKDPLGGNAVHLLGLAARLGLLAAISMAKALQNN--SVETVYLGCNQIGDE------- 195

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 449 wegppscvdfrnmgslrslsldgcGLKALQDCPFQGTSLTHLDLSSNwgvlngSISPLWAVA--------PTLQVLSLRD 520
Cdd:COG5238  196 ------------------------GIEELAEALTQNTTVTTLWLKRN------PIGDEGAEIlaealkgnKSLTTLDLSN 245

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 521 VGLGSGAAEMDFSAFGN---LRALDLSGNSLTSfpkfKGSLALRTLdLRRNSltalpqrvvseqplrGLQTIYLSQNPyd 597
Cdd:COG5238  246 NQIGDEGVIALAEALKNnttVETLYLSGNQIGA----EGAIALAKA-LQGNT---------------TLTSLDLSVNR-- 303

                        250       260       270
                 ....*....|....*....|....*....|...
gi 568995222 598 cCGVEGWGALQQHF---KTVADLSMVTCNLSSK 627
Cdd:COG5238  304 -IGDEGAIALAEGLqgnKTLHTLNLAYNGIGAQ 335
LRR_8 pfam13855
Leucine rich repeat;
402-474 1.95e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.82  E-value: 1.95e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568995222  402 RNLRVFNLSSNQLLGVPTGLFDNASSITTIDMSHNQISLcpqmvpVDWEgppscvDFRNMGSLRSLSLDGCGL 474
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT------LSPG------AFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 81-549 2.11e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.84  E-value: 2.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222  81 PRLENLSLHSCHLD-RISHYAFREQGHLRNLVLADNRLSENY-KESAAALHTL------------------LGLRRLDLS 140
Cdd:PLN00113  93 PYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFTGSIpRGSIPNLETLdlsnnmlsgeipndigsfSSLKVLDLG 172

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 141 GNSLTEDMAAlMLQNLSSLEVVSLARNTL----------MRLDDSIFEGLEHLV-ELDLQrnyifeieggaFDGLTELRR 209
Cdd:PLN00113 173 GNVLVGKIPN-SLTNLTSLEFLTLASNQLvgqiprelgqMKSLKWIYLGYNNLSgEIPYE-----------IGGLTSLNH 240

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 210 LNLAYNNLPCIVDFS---LTQLRFLNVSYNILEWFLAAREEVAFELEILDLSHNQLL--FFPLLPQCGKLHTLLLQDNNM 284
Cdd:PLN00113 241 LDLVYNNLTGPIPSSlgnLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSgeIPELVIQLQNLEILHLFSNNF 320

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 285 GFYRELYNTSSPQEMVAQfllvdgnvtnittvnLWEEFSSSDLSA-------LRFLDMSQNQFR-HLPDGfLKKTPSLSH 356
Cdd:PLN00113 321 TGKIPVALTSLPRLQVLQ---------------LWSNKFSGEIPKnlgkhnnLTVLDLSTNNLTgEIPEG-LCSSGNLFK 384

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 357 LNLNQN------------CLKMLHIR------EHEPPGALTEL------DLSHNQLAelhlapGLTGSLR----NLRVFN 408
Cdd:PLN00113 385 LILFSNslegeipkslgaCRSLRRVRlqdnsfSGELPSEFTKLplvyflDISNNNLQ------GRINSRKwdmpSLQMLS 458

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 409 LSSNQLLGVPTGLFdNASSITTIDMSHNQISlcpQMVPVdwegppscvdfrnmgSLRSLSldgcglkalqdcpfqgtSLT 488
Cdd:PLN00113 459 LARNKFFGGLPDSF-GSKRLENLDLSRNQFS---GAVPR---------------KLGSLS-----------------ELM 502

                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568995222 489 HLDLSSNwgVLNGSISPLWAVAPTLQVLSLRDVGLgSGAAEMDFSAFGNLRALDLSGNSLT 549
Cdd:PLN00113 503 QLKLSEN--KLSGEIPDELSSCKKLVSLDLSHNQL-SGQIPASFSEMPVLSQLDLSQNQLS 560
LRR_8 pfam13855
Leucine rich repeat;
81-144 1.37e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.50  E-value: 1.37e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568995222   81 PRLENLSLHSCHLDRISHYAFREQGHLRNLVLADNRLSEnykESAAALHTLLGLRRLDLSGNSL 144
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT---LSPGAFSGLPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 252-549 2.01e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 41.31  E-value: 2.01e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 252 LEILDLSHNQL------LFFPLLPQCGKLHTLLLQDNNMGfyrelyntsspqemvaqfllvdgnvtnittvnlweefsss 325
Cdd:COG5238  182 VETVYLGCNQIgdegieELAEALTQNTTVTTLWLKRNPIG---------------------------------------- 221

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 326 DLSALRFLDMsqnqfrhlpdgfLKKTPSLSHLNLNQNCLK---MLHIREH-EPPGALTELDLSHNQLAELHLApgltgsl 401
Cdd:COG5238  222 DEGAEILAEA------------LKGNKSLTTLDLSNNQIGdegVIALAEAlKNNTTVETLYLSGNQIGAEGAI------- 282

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 402 rnlrvfnlssnqllGVPTGLFDNaSSITTIDMSHNQIslcpqmvpvdweGPPSCVDF----RNMGSLRSLSLDGCGL--- 474
Cdd:COG5238  283 --------------ALAKALQGN-TTLTSLDLSVNRI------------GDEGAIALaeglQGNKTLHTLNLAYNGIgaq 335

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 475 ------KALQdcpfQGTSLTHLDLSSNwgvlngSISPLWAVA--------PTLQVLSLRDVGLGS-GAAEM-DFSAFGNL 538
Cdd:COG5238  336 gaialaKALQ----ENTTLHSLDLSDN------QIGDEGAIAlakylegnTTLRELNLGKNNIGKqGAEALiDALQTNRL 405

                        330
                 ....*....|.
gi 568995222 539 RALDLSGNSLT 549
Cdd:COG5238  406 HTLILDGNLIG 416
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 377-573 3.29e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 40.54  E-value: 3.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 377 ALTELDLSHNQLAELH---LAPGLTGSLRnLRVFNLSSNQL--LGVpTGLFD---NASSITTIDMSHNQIslcpqmvpvD 448
Cdd:COG5238  209 TVTTLWLKRNPIGDEGaeiLAEALKGNKS-LTTLDLSNNQIgdEGV-IALAEalkNNTTVETLYLSGNQI---------G 277

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 449 WEGppscvdfrnmgsLRSLSldgcglKALQDcpfqGTSLTHLDLSSNWGVLNGSIsplwAVAPTLQVLS-LRDVGLGS-- 525
Cdd:COG5238  278 AEG------------AIALA------KALQG----NTTLTSLDLSVNRIGDEGAI----ALAEGLQGNKtLHTLNLAYng 331

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 526 -GAAEMDFSAFG-----NLRALDLSGNSLT-----SFPKF-KGSLALRTLDLRRNSLTAL 573
Cdd:COG5238  332 iGAQGAIALAKAlqentTLHSLDLSDNQIGdegaiALAKYlEGNTTLRELNLGKNNIGKQ 391
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 107-285 4.94e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 39.77  E-value: 4.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 107 LRNLVLADNRLSEnykESAAALHTLL----GLRRLDLSGNSLTEDMA---ALMLQNLSSLEVVSLARNtlmRLDDsifEG 179
Cdd:COG5238  238 LTTLDLSNNQIGD---EGVIALAEALknntTVETLYLSGNQIGAEGAialAKALQGNTTLTSLDLSVN---RIGD---EG 308

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995222 180 LEHLVELdLQRNyifeieggafdglTELRRLNLAYNNLP---CIvdfsltqlrflnvsynilewFLAAREEVAFELEILD 256
Cdd:COG5238  309 AIALAEG-LQGN-------------KTLHTLNLAYNGIGaqgAI--------------------ALAKALQENTTLHSLD 354

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 568995222 257 LSHNQL------LFFPLLPQCGKLHTLLLQDNNMG 285
Cdd:COG5238  355 LSDNQIgdegaiALAKYLEGNTTLRELNLGKNNIG 389
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
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