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Conserved domains on  [gi|568991387|ref|XP_006520517|]
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hematopoietic cell transcript 1 isoform X2 [Mus musculus]

Protein Classification

Ly-6/uPAR domain-containing protein( domain architecture ID 10061478)

LU (Ly-6 antigen/uPA receptor-like) domain-containing protein similar to GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TFP_LU_ECD_GML cd23555
extracellular domain (ECD) found in glycosyl-phosphatidylinositol-anchored molecule-like ...
 47-133 1.69e-48

extracellular domain (ECD) found in glycosyl-phosphatidylinositol-anchored molecule-like protein (GML) and similar proteins; GML may play a role in the apoptotic pathway or cell-cycle regulation induced by p53/TP53 after DNA damage. It contains an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


:

Pssm-ID: 467085  Cd Length: 87  Bit Score: 152.15  E-value: 1.69e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991387  47 LTCHKCYISNTFSCPKLSECPSNLRRCMTVSFRVNIRLLYVLKDCTKDCTFIYREHVPPELPRVLKDVKNFYFVMCCSSI 126
Cdd:cd23555    1 LRCHSCAVINTFNCPAHRTCPYDIRRCMTVAIRVNSRELLVYKNCTKNCTFVYAEEQPPEAPRKIPKTNSFYFVMCCSSM 80


                 ....*..
gi 568991387 127 TCNVGGP 133
Cdd:cd23555   81 FCNEGGP 87
 
Name Accession Description Interval E-value
TFP_LU_ECD_GML cd23555
extracellular domain (ECD) found in glycosyl-phosphatidylinositol-anchored molecule-like ...
 47-133 1.69e-48

extracellular domain (ECD) found in glycosyl-phosphatidylinositol-anchored molecule-like protein (GML) and similar proteins; GML may play a role in the apoptotic pathway or cell-cycle regulation induced by p53/TP53 after DNA damage. It contains an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467085  Cd Length: 87  Bit Score: 152.15  E-value: 1.69e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991387  47 LTCHKCYISNTFSCPKLSECPSNLRRCMTVSFRVNIRLLYVLKDCTKDCTFIYREHVPPELPRVLKDVKNFYFVMCCSSI 126
Cdd:cd23555    1 LRCHSCAVINTFNCPAHRTCPYDIRRCMTVAIRVNSRELLVYKNCTKNCTFVYAEEQPPEAPRKIPKTNSFYFVMCCSSM 80


                 ....*..
gi 568991387 127 TCNVGGP 133
Cdd:cd23555   81 FCNEGGP 87
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 47-134 3.52e-06

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 43.29  E-value: 3.52e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991387    47 LTCHKCYISNTFSCPKLSECPSNLRRCMTVSFRVNI--RLLYVLKDCTK--DCTFIYREHVppelprvlKDVKNFYFVMC 122
Cdd:smart00134   1 LQCYSCTGNPDSSCSSEEECRSPDDVCLTVVAEVISdsRGSVVYKGCATspICPGSHGYEI--------NLTIAFLKVSC 72

                           90
                   ....*....|..
gi 568991387   123 CSSITCNVGGPT 134
Cdd:smart00134  73 CQTDLCNAAGPG 84
 
Name Accession Description Interval E-value
TFP_LU_ECD_GML cd23555
extracellular domain (ECD) found in glycosyl-phosphatidylinositol-anchored molecule-like ...
 47-133 1.69e-48

extracellular domain (ECD) found in glycosyl-phosphatidylinositol-anchored molecule-like protein (GML) and similar proteins; GML may play a role in the apoptotic pathway or cell-cycle regulation induced by p53/TP53 after DNA damage. It contains an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467085  Cd Length: 87  Bit Score: 152.15  E-value: 1.69e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991387  47 LTCHKCYISNTFSCPKLSECPSNLRRCMTVSFRVNIRLLYVLKDCTKDCTFIYREHVPPELPRVLKDVKNFYFVMCCSSI 126
Cdd:cd23555    1 LRCHSCAVINTFNCPAHRTCPYDIRRCMTVAIRVNSRELLVYKNCTKNCTFVYAEEQPPEAPRKIPKTNSFYFVMCCSSM 80


                 ....*..
gi 568991387 127 TCNVGGP 133
Cdd:cd23555   81 FCNEGGP 87
TFP_LU_ECD_Ly6K cd23550
extracellular domain (ECD) found in lymphocyte antigen 6K (Ly-6K) and similar proteins; Ly-6K ...
 47-133 2.34e-13

extracellular domain (ECD) found in lymphocyte antigen 6K (Ly-6K) and similar proteins; Ly-6K is required for sperm migration into the oviduct and male fertility by controlling binding of sperm to zona pellucida. It may play a role in cell growth. Ly-6K contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467080  Cd Length: 86  Bit Score: 62.33  E-value: 2.34e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991387  47 LTCHKCYISNTFSCPKLSECPSNLRRCMTVSFRVNIRLLYVLKDCTKDCTFIYREHVPPElPRVLKDVKNFYFVMCCSSI 126
Cdd:cd23550    1 LTCHVCEVENSFNCTNPVTCTWEETYCVLAAVRIFPRFFLVSKQCSKYCPVVEVPPPPPK-SFVLEKPMPFLYIKCCREN 79


                 ....*..
gi 568991387 127 TCNVGGP 133
Cdd:cd23550   80 LCNEEGP 86
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 47-134 3.52e-06

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 43.29  E-value: 3.52e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991387    47 LTCHKCYISNTFSCPKLSECPSNLRRCMTVSFRVNI--RLLYVLKDCTK--DCTFIYREHVppelprvlKDVKNFYFVMC 122
Cdd:smart00134   1 LQCYSCTGNPDSSCSSEEECRSPDDVCLTVVAEVISdsRGSVVYKGCATspICPGSHGYEI--------NLTIAFLKVSC 72

                           90
                   ....*....|..
gi 568991387   123 CSSITCNVGGPT 134
Cdd:smart00134  73 CQTDLCNAAGPG 84
TFP cd00117
three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU ...
 47-129 3.01e-03

three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU (also known as Ly-6 antigen/uPA receptor)-like extracellular domain (ECD) occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. It is a structural domain involved in protein-protein interactions, tolerating an unusual degree of variation and binding with high specificity to a broad spectrum of targets. The snake toxin domain is present in short and long neurotoxins, cytotoxins, and short toxins, and in other miscellaneous venom peptides. The toxin acts by binding to the nicotinic acetylcholine receptors in the postsynaptic membrane of skeletal muscles and preventing the binding of acetylcholine, thereby blocking the excitation of muscles. Both the LU-like ECD and the snake toxin domain belong to three-fingered protein (TFP) fold, which is characterized by containing 70 to 100 amino acids including eight to ten cysteine residues spaced at conserved distances.


Pssm-ID: 467060  Cd Length: 81  Bit Score: 35.15  E-value: 3.01e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991387  47 LTCHKCYISNTFSC----PKLSECPSNLRRCMTVSFRVNIRLLYVLKDCTKDCTFIYREHVPpelprvLKDVKNFYFVMC 122
Cdd:cd00117    1 LKCYQCNSSNDPNCcnssPTLVTCSSPETFCRKIVGKVGGGETLVIRGCATECECGCTECCS------GTGTSGTTCTSC 74


                 ....*..
gi 568991387 123 CSSITCN 129
Cdd:cd00117   75 CDTDLCN 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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