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Conserved domains on  [gi|568983621|ref|XP_006517437|]
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nucleotide sugar transporter SLC35D2 isoform X4 [Mus musculus]

Protein Classification

triose-phosphate transporter family protein( domain architecture ID 706146)

triose-phosphate transporter family protein belongs to the RhaT/DMT (drug/metabolite transporter) superfamily

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TPT super family cl26744
Triose-phosphate Transporter family; This family includes transporters with a specificity for ...
 12-195 4.72e-08

Triose-phosphate Transporter family; This family includes transporters with a specificity for triose phosphate.


The actual alignment was detected with superfamily member pfam03151:

Pssm-ID: 474852 [Multi-domain]  Cd Length: 290  Bit Score: 52.29  E-value: 4.72e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568983621   12 FTLLLEAIILGTQYSLNIILSVLAIVLGAFIAAGSDLTFNLEGYIFVFLNDIFTAANGVYTKQKMDPKE----LGKYGVL 87
Cdd:pfam03151 104 FTVILSRLFLGEYPPLLVYLSLLPIVGGVALASVTELSFNWIGFISAMISNLGFSLRNIFSKKLMKGKDnldnLNLFAII 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568983621   88 FYNACFMLIPTVIISVSTGDFQQ--ATEFRHWKNVLFIIqFLLSCLLGFLLMYSTALCSYYnSALTTAVVGAIKNVSVAY 165
Cdd:pfam03151 184 TILSLLLLLPVWLLVEGFKKFPSllQSGKVGLKDVYMLL-LLSGVCFHLYNQVAYMILERV-SPVTHSVANTVKRVVVIV 261

                         170       180       190
                  ....*....|....*....|....*....|
gi 568983621  166 IGMLVGGDYIfSLLNFIGLNICMAGGLRYS 195
Cdd:pfam03151 262 SSILVFGNPV-SPLNAIGTAIAIAGVFLYS 290
 
Name Accession Description Interval E-value
TPT pfam03151
Triose-phosphate Transporter family; This family includes transporters with a specificity for ...
 12-195 4.72e-08

Triose-phosphate Transporter family; This family includes transporters with a specificity for triose phosphate.


Pssm-ID: 308657 [Multi-domain]  Cd Length: 290  Bit Score: 52.29  E-value: 4.72e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568983621   12 FTLLLEAIILGTQYSLNIILSVLAIVLGAFIAAGSDLTFNLEGYIFVFLNDIFTAANGVYTKQKMDPKE----LGKYGVL 87
Cdd:pfam03151 104 FTVILSRLFLGEYPPLLVYLSLLPIVGGVALASVTELSFNWIGFISAMISNLGFSLRNIFSKKLMKGKDnldnLNLFAII 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568983621   88 FYNACFMLIPTVIISVSTGDFQQ--ATEFRHWKNVLFIIqFLLSCLLGFLLMYSTALCSYYnSALTTAVVGAIKNVSVAY 165
Cdd:pfam03151 184 TILSLLLLLPVWLLVEGFKKFPSllQSGKVGLKDVYMLL-LLSGVCFHLYNQVAYMILERV-SPVTHSVANTVKRVVVIV 261

                         170       180       190
                  ....*....|....*....|....*....|
gi 568983621  166 IGMLVGGDYIfSLLNFIGLNICMAGGLRYS 195
Cdd:pfam03151 262 SSILVFGNPV-SPLNAIGTAIAIAGVFLYS 290
tpt TIGR00817
Tpt phosphate/phosphoenolpyruvate translocator; The 6-8 TMS Triose-phosphate Transporter (TPT) ...
 12-200 6.32e-05

Tpt phosphate/phosphoenolpyruvate translocator; The 6-8 TMS Triose-phosphate Transporter (TPT) Family (TC 2.A.7.9)Functionally characterized members of the TPT family are derived from the inner envelope membranes of chloroplasts and nongreen plastids of plants. However,homologues are also present in yeast. Saccharomyces cerevisiae has three functionally uncharacterized TPT paralogues encoded within its genome. Under normal physiologicalconditions, chloroplast TPTs mediate a strict antiport of substrates, frequently exchanging an organic three carbon compound phosphate ester for inorganic phosphate (Pi).Normally, a triose-phosphate, 3-phosphoglycerate, or another phosphorylated C3 compound made in the chloroplast during photosynthesis, exits the organelle into thecytoplasm of the plant cell in exchange for Pi. However, experiments with reconstituted translocator in artificial membranes indicate that transport can also occur by achannel-like uniport mechanism with up to 10-fold higher transport rates. Channel opening may be induced by a membrane potential of large magnitude and/or by high substrateconcentrations. Nongreen plastid and chloroplast carriers, such as those from maize endosperm and root membranes, mediate transport of C3 compounds phosphorylated atcarbon atom 2, particularly phosphenolpyruvate, in exchange for Pi. These are the phosphoenolpyruvate:Pi antiporters (PPT). Glucose-6-P has also been shown to be asubstrate of some plastid translocators (GPT). The three types of proteins (TPT, PPT and GPT) are divergent in sequence as well as substrate specificity, but their substratespecificities overlap. [Hypothetical proteins, Conserved]


Pssm-ID: 129898 [Multi-domain]  Cd Length: 302  Bit Score: 42.79  E-value: 6.32e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568983621   12 FTLLLEAIILGTQYSLNIILSVLAIVLGAFIAAGSDLTFNLEGYIFVFLNDIFTAANGVYTKQKMDPKELGKYG------ 85
Cdd:TIGR00817 104 FSVVLSAFFLGQEFPSTLWLSLLPIVGGVALASDTELSFNWAGFLSAMISNITFVSRNIFSKKAMTIKSLDKTNlyayis 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568983621   86 --VLFYNACFMLIpTVIISVSTGDFQQATEFRHWKNVLFIIQFLLSCLLGFLLMYSTALCSYYnSALTTAVVGAIKNVSV 163
Cdd:TIGR00817 184 imSLFLLSPPAFI-TEGPPFLPHGFMQAISGVNVTKIYTVSLVAAMGFFHFYQQVAFMLLGRV-SPLTHSVGNCMKRVVV 261

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 568983621  164 AYIGMLVGGDYIfSLLNFIGLNICMAGGLRYSFLTLS 200
Cdd:TIGR00817 262 IVVSILFFGTKI-SPQQVFGTGIAIAGVFLYSRVKAQ 297
TPT_S35C2 cd21092
solute carrier family 35 member C2, member of the triose-phosphate transporter family; Solute ...
 1-190 7.66e-04

solute carrier family 35 member C2, member of the triose-phosphate transporter family; Solute carrier family 35 member C2 (S35C2 or Slc35c2), also called ovarian cancer-overexpressed gene 1 protein (OVCOV1), is a member of the triose-phosphate transporter (TPT) family, which is part of the drug/metabolite transporter (DMT) superfamily. It may function either as a GDP-fucose transporter that competes with Slc35c1 (S35C1) for GDP-fucose, or a factor that otherwise enhances the fucosylation of Notch and is required for optimal Notch signaling in mammalian cells.


Pssm-ID: 411044  Cd Length: 248  Bit Score: 39.56  E-value: 7.66e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568983621   1 MFTVLRKFTIPFTLLLEAIILGTQYSLNIILSVLAIVLGAFIAAGSDLTFNLEGYIFVFLNDIFTAANGVYTKQKMDPKE 80
Cdd:cd21092   33 LYTMTKSSAIIFILFFSLVFKLEKPRWSLVLVVLLIAGGLFMFTYKSTQFNLEGFILVLSASFLGGLRWTLAQLLMQKAE 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568983621  81 LGKYGVLfyNACFMLIPTVIIS----------VSTGDFQQATEFRHWKNVLFIIQFLLSCLLGFLLM-YSTALCSYYNSA 149
Cdd:cd21092  113 LGLQNPI--DMMYHLQPWMILGllplaigfegLHLATSEKLFRFHDSSVLLRTLGYLLLGAVLAFGLeFSEFLLVSKTSS 190

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 568983621 150 LTTAVVGAIKNVSVAYIGMLVGGDYIfSLLNFIGLNICMAG 190
Cdd:cd21092  191 LTLSIAGIFKEICTLLLAVHINGDHL-SLLNWLGLVICLCG 230
PTZ00343 PTZ00343
triose or hexose phosphate/phosphate translocator; Provisional
 12-195 2.13e-03

triose or hexose phosphate/phosphate translocator; Provisional


Pssm-ID: 240371 [Multi-domain]  Cd Length: 350  Bit Score: 38.56  E-value: 2.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568983621  12 FTLLLEAIILGTQYSLNIILSVLAIVLGAFIAAGSDLTFNLEGYIFVFLNDIFTAANGVYTKQKM-DPKELGKYgvLFYN 90
Cdd:PTZ00343 153 FTALLSILFLKQFLNLYAYLSLIPIVGGVALASVKELHFTWLAFWCAMLSNLGSSLRSIFAKKTMkNKSEIGEN--LTAS 230

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568983621  91 ACFMLIpTVIISVSTGDFQQATEFRHWKNVL------------FIIQFLLSCLLGFLLMY--STALCSYYNSALTTAVVG 156
Cdd:PTZ00343 231 NIYMLL-TLIASLISLPLVLFFEGKKWVPVWtnytanmtnytkGIIIFKIFFSGVWYYLYneVAFYCLGKVNQVTHAVAN 309

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 568983621 157 AIKNVSVAYIGMLVGGDYIfSLLNFIGLNICMAGGLRYS 195
Cdd:PTZ00343 310 TLKRVVIIVSSIIIFQTQV-TLLGYLGMAVAILGALLYS 347
 
Name Accession Description Interval E-value
TPT pfam03151
Triose-phosphate Transporter family; This family includes transporters with a specificity for ...
 12-195 4.72e-08

Triose-phosphate Transporter family; This family includes transporters with a specificity for triose phosphate.


Pssm-ID: 308657 [Multi-domain]  Cd Length: 290  Bit Score: 52.29  E-value: 4.72e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568983621   12 FTLLLEAIILGTQYSLNIILSVLAIVLGAFIAAGSDLTFNLEGYIFVFLNDIFTAANGVYTKQKMDPKE----LGKYGVL 87
Cdd:pfam03151 104 FTVILSRLFLGEYPPLLVYLSLLPIVGGVALASVTELSFNWIGFISAMISNLGFSLRNIFSKKLMKGKDnldnLNLFAII 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568983621   88 FYNACFMLIPTVIISVSTGDFQQ--ATEFRHWKNVLFIIqFLLSCLLGFLLMYSTALCSYYnSALTTAVVGAIKNVSVAY 165
Cdd:pfam03151 184 TILSLLLLLPVWLLVEGFKKFPSllQSGKVGLKDVYMLL-LLSGVCFHLYNQVAYMILERV-SPVTHSVANTVKRVVVIV 261

                         170       180       190
                  ....*....|....*....|....*....|
gi 568983621  166 IGMLVGGDYIfSLLNFIGLNICMAGGLRYS 195
Cdd:pfam03151 262 SSILVFGNPV-SPLNAIGTAIAIAGVFLYS 290
tpt TIGR00817
Tpt phosphate/phosphoenolpyruvate translocator; The 6-8 TMS Triose-phosphate Transporter (TPT) ...
 12-200 6.32e-05

Tpt phosphate/phosphoenolpyruvate translocator; The 6-8 TMS Triose-phosphate Transporter (TPT) Family (TC 2.A.7.9)Functionally characterized members of the TPT family are derived from the inner envelope membranes of chloroplasts and nongreen plastids of plants. However,homologues are also present in yeast. Saccharomyces cerevisiae has three functionally uncharacterized TPT paralogues encoded within its genome. Under normal physiologicalconditions, chloroplast TPTs mediate a strict antiport of substrates, frequently exchanging an organic three carbon compound phosphate ester for inorganic phosphate (Pi).Normally, a triose-phosphate, 3-phosphoglycerate, or another phosphorylated C3 compound made in the chloroplast during photosynthesis, exits the organelle into thecytoplasm of the plant cell in exchange for Pi. However, experiments with reconstituted translocator in artificial membranes indicate that transport can also occur by achannel-like uniport mechanism with up to 10-fold higher transport rates. Channel opening may be induced by a membrane potential of large magnitude and/or by high substrateconcentrations. Nongreen plastid and chloroplast carriers, such as those from maize endosperm and root membranes, mediate transport of C3 compounds phosphorylated atcarbon atom 2, particularly phosphenolpyruvate, in exchange for Pi. These are the phosphoenolpyruvate:Pi antiporters (PPT). Glucose-6-P has also been shown to be asubstrate of some plastid translocators (GPT). The three types of proteins (TPT, PPT and GPT) are divergent in sequence as well as substrate specificity, but their substratespecificities overlap. [Hypothetical proteins, Conserved]


Pssm-ID: 129898 [Multi-domain]  Cd Length: 302  Bit Score: 42.79  E-value: 6.32e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568983621   12 FTLLLEAIILGTQYSLNIILSVLAIVLGAFIAAGSDLTFNLEGYIFVFLNDIFTAANGVYTKQKMDPKELGKYG------ 85
Cdd:TIGR00817 104 FSVVLSAFFLGQEFPSTLWLSLLPIVGGVALASDTELSFNWAGFLSAMISNITFVSRNIFSKKAMTIKSLDKTNlyayis 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568983621   86 --VLFYNACFMLIpTVIISVSTGDFQQATEFRHWKNVLFIIQFLLSCLLGFLLMYSTALCSYYnSALTTAVVGAIKNVSV 163
Cdd:TIGR00817 184 imSLFLLSPPAFI-TEGPPFLPHGFMQAISGVNVTKIYTVSLVAAMGFFHFYQQVAFMLLGRV-SPLTHSVGNCMKRVVV 261

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 568983621  164 AYIGMLVGGDYIfSLLNFIGLNICMAGGLRYSFLTLS 200
Cdd:TIGR00817 262 IVVSILFFGTKI-SPQQVFGTGIAIAGVFLYSRVKAQ 297
TPT_S35C2 cd21092
solute carrier family 35 member C2, member of the triose-phosphate transporter family; Solute ...
 1-190 7.66e-04

solute carrier family 35 member C2, member of the triose-phosphate transporter family; Solute carrier family 35 member C2 (S35C2 or Slc35c2), also called ovarian cancer-overexpressed gene 1 protein (OVCOV1), is a member of the triose-phosphate transporter (TPT) family, which is part of the drug/metabolite transporter (DMT) superfamily. It may function either as a GDP-fucose transporter that competes with Slc35c1 (S35C1) for GDP-fucose, or a factor that otherwise enhances the fucosylation of Notch and is required for optimal Notch signaling in mammalian cells.


Pssm-ID: 411044  Cd Length: 248  Bit Score: 39.56  E-value: 7.66e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568983621   1 MFTVLRKFTIPFTLLLEAIILGTQYSLNIILSVLAIVLGAFIAAGSDLTFNLEGYIFVFLNDIFTAANGVYTKQKMDPKE 80
Cdd:cd21092   33 LYTMTKSSAIIFILFFSLVFKLEKPRWSLVLVVLLIAGGLFMFTYKSTQFNLEGFILVLSASFLGGLRWTLAQLLMQKAE 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568983621  81 LGKYGVLfyNACFMLIPTVIIS----------VSTGDFQQATEFRHWKNVLFIIQFLLSCLLGFLLM-YSTALCSYYNSA 149
Cdd:cd21092  113 LGLQNPI--DMMYHLQPWMILGllplaigfegLHLATSEKLFRFHDSSVLLRTLGYLLLGAVLAFGLeFSEFLLVSKTSS 190

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 568983621 150 LTTAVVGAIKNVSVAYIGMLVGGDYIfSLLNFIGLNICMAG 190
Cdd:cd21092  191 LTLSIAGIFKEICTLLLAVHINGDHL-SLLNWLGLVICLCG 230
PTZ00343 PTZ00343
triose or hexose phosphate/phosphate translocator; Provisional
 12-195 2.13e-03

triose or hexose phosphate/phosphate translocator; Provisional


Pssm-ID: 240371 [Multi-domain]  Cd Length: 350  Bit Score: 38.56  E-value: 2.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568983621  12 FTLLLEAIILGTQYSLNIILSVLAIVLGAFIAAGSDLTFNLEGYIFVFLNDIFTAANGVYTKQKM-DPKELGKYgvLFYN 90
Cdd:PTZ00343 153 FTALLSILFLKQFLNLYAYLSLIPIVGGVALASVKELHFTWLAFWCAMLSNLGSSLRSIFAKKTMkNKSEIGEN--LTAS 230

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568983621  91 ACFMLIpTVIISVSTGDFQQATEFRHWKNVL------------FIIQFLLSCLLGFLLMY--STALCSYYNSALTTAVVG 156
Cdd:PTZ00343 231 NIYMLL-TLIASLISLPLVLFFEGKKWVPVWtnytanmtnytkGIIIFKIFFSGVWYYLYneVAFYCLGKVNQVTHAVAN 309

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 568983621 157 AIKNVSVAYIGMLVGGDYIfSLLNFIGLNICMAGGLRYS 195
Cdd:PTZ00343 310 TLKRVVIIVSSIIIFQTQV-TLLGYLGMAVAILGALLYS 347
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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