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Conserved domains on  [gi|568980650|ref|XP_006516416|]
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condensin-2 complex subunit G2 isoform X1 [Mus musculus]

Protein Classification

condensin-2 complex subunit G2 family protein( domain architecture ID 10575316)

condensin-2 complex subunit G2 (NCAPG2) family protein similar to NCAPG2, a regulatory subunit of the condensin-2 complex, which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Condensin2nSMC pfam12422
Condensin II non structural maintenance of chromosomes subunit; This domain family is found in ...
 213-361 4.63e-76

Condensin II non structural maintenance of chromosomes subunit; This domain family is found in eukaryotes, and is approximately 150 amino acids in length. This family is part of a non-SMC subunit of condensin II which is involved in maintenance of the structural integrity of chromosomes. Condensin II is made up of SMC (structural maintenance of chromosomes) and non-SMC subunits. The non-SMC subunits bind to the catalytic ends of the SMC subunit dimer. The condensin holocomplex is able to introduce superhelical tension into DNA in an ATP hydrolysis- dependent manner, resulting in the formation of positive supercoils in the presence of topoisomerase I and of positive knots in the presence of topoisomerase II.


:

Pssm-ID: 463573  Cd Length: 149  Bit Score: 247.09  E-value: 4.63e-76
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980650   213 CFINVNYIKKEEGRRFLSFLFSWNVDFIKMIHETIKNQLAGLQKSLMVHIAEIYFRAWKKASGKMLETIEYDCIQDFMFH 292
Cdd:pfam12422    2 CFISPAFLKTEEGRRFLAFLFSLSVQLVKEIHATIKNQLPFLTKSLLEAYGEIYFRAWKNASGDLLEEIEEDCIQDLMQH 81

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568980650   293 GIHlLRRSPVHSKVREVLSYFHQQKVRQGVEEMLYRLYKPILWRGLKARNSEVRSNAALLFVEAFPIRD 361
Cdd:pfam12422   82 AIH-ASRPPLASKVRRVLSYFHSQKKDKGVDEMLTRLYEPILWRSLKVANSEVRANATLLFFDAFPLED 149
 
Name Accession Description Interval E-value
Condensin2nSMC pfam12422
Condensin II non structural maintenance of chromosomes subunit; This domain family is found in ...
 213-361 4.63e-76

Condensin II non structural maintenance of chromosomes subunit; This domain family is found in eukaryotes, and is approximately 150 amino acids in length. This family is part of a non-SMC subunit of condensin II which is involved in maintenance of the structural integrity of chromosomes. Condensin II is made up of SMC (structural maintenance of chromosomes) and non-SMC subunits. The non-SMC subunits bind to the catalytic ends of the SMC subunit dimer. The condensin holocomplex is able to introduce superhelical tension into DNA in an ATP hydrolysis- dependent manner, resulting in the formation of positive supercoils in the presence of topoisomerase I and of positive knots in the presence of topoisomerase II.


Pssm-ID: 463573  Cd Length: 149  Bit Score: 247.09  E-value: 4.63e-76
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980650   213 CFINVNYIKKEEGRRFLSFLFSWNVDFIKMIHETIKNQLAGLQKSLMVHIAEIYFRAWKKASGKMLETIEYDCIQDFMFH 292
Cdd:pfam12422    2 CFISPAFLKTEEGRRFLAFLFSLSVQLVKEIHATIKNQLPFLTKSLLEAYGEIYFRAWKNASGDLLEEIEEDCIQDLMQH 81

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568980650   293 GIHlLRRSPVHSKVREVLSYFHQQKVRQGVEEMLYRLYKPILWRGLKARNSEVRSNAALLFVEAFPIRD 361
Cdd:pfam12422   82 AIH-ASRPPLASKVRRVLSYFHSQKKDKGVDEMLTRLYEPILWRSLKVANSEVRANATLLFFDAFPLED 149
 
Name Accession Description Interval E-value
Condensin2nSMC pfam12422
Condensin II non structural maintenance of chromosomes subunit; This domain family is found in ...
 213-361 4.63e-76

Condensin II non structural maintenance of chromosomes subunit; This domain family is found in eukaryotes, and is approximately 150 amino acids in length. This family is part of a non-SMC subunit of condensin II which is involved in maintenance of the structural integrity of chromosomes. Condensin II is made up of SMC (structural maintenance of chromosomes) and non-SMC subunits. The non-SMC subunits bind to the catalytic ends of the SMC subunit dimer. The condensin holocomplex is able to introduce superhelical tension into DNA in an ATP hydrolysis- dependent manner, resulting in the formation of positive supercoils in the presence of topoisomerase I and of positive knots in the presence of topoisomerase II.


Pssm-ID: 463573  Cd Length: 149  Bit Score: 247.09  E-value: 4.63e-76
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568980650   213 CFINVNYIKKEEGRRFLSFLFSWNVDFIKMIHETIKNQLAGLQKSLMVHIAEIYFRAWKKASGKMLETIEYDCIQDFMFH 292
Cdd:pfam12422    2 CFISPAFLKTEEGRRFLAFLFSLSVQLVKEIHATIKNQLPFLTKSLLEAYGEIYFRAWKNASGDLLEEIEEDCIQDLMQH 81

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568980650   293 GIHlLRRSPVHSKVREVLSYFHQQKVRQGVEEMLYRLYKPILWRGLKARNSEVRSNAALLFVEAFPIRD 361
Cdd:pfam12422   82 AIH-ASRPPLASKVRRVLSYFHSQKKDKGVDEMLTRLYEPILWRSLKVANSEVRANATLLFFDAFPLED 149
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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