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Conserved domains on  [gi|568979227|ref|XP_006515725|]
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WD repeat-containing protein 25 isoform X3 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 228-441 4.68e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 81.23  E-value: 4.68e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979227 228 KVLFHLRGHRGPVNSIQWCPvfcKSHMLLSASMDKTFKVVKGYKATIQQTL--------DILFLQEGSeFLSSTdastrd 299
Cdd:cd00200   84 ECVRTLTGHTSYVSSVAFSP---DGRILSSSSRDKTIKVWDVETGKCLTTLrghtdwvnSVAFSPDGT-FVASS------ 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979227 300 SADRTIIAWDFRTAAKISNQIFHERYtCPSLALHPREPVFLAQTNGNylalFSSVWPYRMSR-RRRYEGHkvEGYAVGCE 378
Cdd:cd00200  154 SQDGTIKLWDLRTGKCVATLTGHTGE-VNSVAFSPDGEKLLSSSSDG----TIKLWDLSTGKcLGTLRGH--ENGVNSVA 226

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568979227 379 CSPCGDLLVTGSADGRVLMFSFRTASRACTLQGHTQACLGTTYHPvLPSVLGTCSWGGDIKIW 441
Cdd:cd00200  227 FSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSP-DGKRLASGSADGTIRIW 288
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 228-441 4.68e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 81.23  E-value: 4.68e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979227 228 KVLFHLRGHRGPVNSIQWCPvfcKSHMLLSASMDKTFKVVKGYKATIQQTL--------DILFLQEGSeFLSSTdastrd 299
Cdd:cd00200   84 ECVRTLTGHTSYVSSVAFSP---DGRILSSSSRDKTIKVWDVETGKCLTTLrghtdwvnSVAFSPDGT-FVASS------ 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979227 300 SADRTIIAWDFRTAAKISNQIFHERYtCPSLALHPREPVFLAQTNGNylalFSSVWPYRMSR-RRRYEGHkvEGYAVGCE 378
Cdd:cd00200  154 SQDGTIKLWDLRTGKCVATLTGHTGE-VNSVAFSPDGEKLLSSSSDG----TIKLWDLSTGKcLGTLRGH--ENGVNSVA 226

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568979227 379 CSPCGDLLVTGSADGRVLMFSFRTASRACTLQGHTQACLGTTYHPvLPSVLGTCSWGGDIKIW 441
Cdd:cd00200  227 FSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSP-DGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
228-441 2.76e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 74.18  E-value: 2.76e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979227 228 KVLFHLRGHRGPVNSIQWCPvfcKSHMLLSASMDKTFKVVKGYKATIQQTL--------DILFLQEGSEFLSStdastrd 299
Cdd:COG2319  195 KLLRTLTGHTGAVRSVAFSP---DGKLLASGSADGTVRLWDLATGKLLRTLtghsgsvrSVAFSPDGRLLASG------- 264

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979227 300 SADRTIIAWDFRTAAKISNQIFHERYTCpSLALHPrepvflaqtNGNYLALFSS-----VWPYRMSRRRR-YEGHKVEGY 373
Cdd:COG2319  265 SADGTVRLWDLATGELLRTLTGHSGGVN-SVAFSP---------DGKLLASGSDdgtvrLWDLATGKLLRtLTGHTGAVR 334

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568979227 374 AVgcECSPCGDLLVTGSADGRVLMFSFRTASRACTLQGHTQACLGTTYHPVlPSVLGTCSWGGDIKIW 441
Cdd:COG2319  335 SV--AFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPD-GRTLASGSADGTVRLW 399
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 226-266 3.31e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 3.31e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 568979227   226 PKKVLFHLRGHRGPVNSIQWCPvfcKSHMLLSASMDKTFKV 266
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP---DGKYLASGSDDGTIKL 38
WD40 pfam00400
WD domain, G-beta repeat;
227-266 7.00e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 7.00e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 568979227  227 KKVLFHLRGHRGPVNSIQWCPvfcKSHMLLSASMDKTFKV 266
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSP---DGKLLASGSDDGTVKV 37
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 228-441 4.68e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 81.23  E-value: 4.68e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979227 228 KVLFHLRGHRGPVNSIQWCPvfcKSHMLLSASMDKTFKVVKGYKATIQQTL--------DILFLQEGSeFLSSTdastrd 299
Cdd:cd00200   84 ECVRTLTGHTSYVSSVAFSP---DGRILSSSSRDKTIKVWDVETGKCLTTLrghtdwvnSVAFSPDGT-FVASS------ 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979227 300 SADRTIIAWDFRTAAKISNQIFHERYtCPSLALHPREPVFLAQTNGNylalFSSVWPYRMSR-RRRYEGHkvEGYAVGCE 378
Cdd:cd00200  154 SQDGTIKLWDLRTGKCVATLTGHTGE-VNSVAFSPDGEKLLSSSSDG----TIKLWDLSTGKcLGTLRGH--ENGVNSVA 226

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568979227 379 CSPCGDLLVTGSADGRVLMFSFRTASRACTLQGHTQACLGTTYHPvLPSVLGTCSWGGDIKIW 441
Cdd:cd00200  227 FSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSP-DGKRLASGSADGTIRIW 288
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 230-441 7.03e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 77.76  E-value: 7.03e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979227 230 LFHLRGHRGPVNSIQWCPVfckSHMLLSASMDKTFKVVKGYKATIQQTL--------DILFLQEGSEFLSStdastrdSA 301
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSPD---GKLLATGSGDGTIKVWDLETGELLRTLkghtgpvrDVAASADGTYLASG-------SS 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979227 302 DRTIIAWDFRTAAKISNQIFHERYTCpSLALHPREPVFLAqtngnylalfSS------VWPYRMSR-RRRYEGHkvEGYA 374
Cdd:cd00200   72 DKTIRLWDLETGECVRTLTGHTSYVS-SVAFSPDGRILSS----------SSrdktikVWDVETGKcLTTLRGH--TDWV 138

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568979227 375 VGCECSPCGDLLVTGSADGRVLMFSFRTASRACTLQGHTQACLGTTYHPVLPSVLgTCSWGGDIKIW 441
Cdd:cd00200  139 NSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLL-SSSSDGTIKLW 204
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 229-441 8.57e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 77.38  E-value: 8.57e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979227 229 VLFHLRGHRGPVNSIQWCpvfCKSHMLLSASMDKTFKV-----------VKGYKATIqqtLDILFLQEGSEFLSStdast 297
Cdd:cd00200   43 LLRTLKGHTGPVRDVAAS---ADGTYLASGSSDKTIRLwdletgecvrtLTGHTSYV---SSVAFSPDGRILSSS----- 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979227 298 rdSADRTIIAWDFRTAAKISNQIFHERYTCpSLALHPrepvflaqtNGNYLALFSS-----VWPYR-MSRRRRYEGHKVE 371
Cdd:cd00200  112 --SRDKTIKVWDVETGKCLTTLRGHTDWVN-SVAFSP---------DGTFVASSSQdgtikLWDLRtGKCVATLTGHTGE 179

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979227 372 GYAVgcECSPCGDLLVTGSADGRVLMFSFRTASRACTLQGHTQACLGTTYHPVlPSVLGTCSWGGDIKIW 441
Cdd:cd00200  180 VNSV--AFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPD-GYLLASGSEDGTIRVW 246
WD40 COG2319
WD40 repeat [General function prediction only];
228-441 2.76e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 74.18  E-value: 2.76e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979227 228 KVLFHLRGHRGPVNSIQWCPvfcKSHMLLSASMDKTFKVVKGYKATIQQTL--------DILFLQEGSEFLSStdastrd 299
Cdd:COG2319  195 KLLRTLTGHTGAVRSVAFSP---DGKLLASGSADGTVRLWDLATGKLLRTLtghsgsvrSVAFSPDGRLLASG------- 264

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979227 300 SADRTIIAWDFRTAAKISNQIFHERYTCpSLALHPrepvflaqtNGNYLALFSS-----VWPYRMSRRRR-YEGHKVEGY 373
Cdd:COG2319  265 SADGTVRLWDLATGELLRTLTGHSGGVN-SVAFSP---------DGKLLASGSDdgtvrLWDLATGKLLRtLTGHTGAVR 334

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568979227 374 AVgcECSPCGDLLVTGSADGRVLMFSFRTASRACTLQGHTQACLGTTYHPVlPSVLGTCSWGGDIKIW 441
Cdd:COG2319  335 SV--AFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPD-GRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
228-442 1.92e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 68.40  E-value: 1.92e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979227 228 KVLFHLRGHRGPVNSIQWCPvfcKSHMLLSASMDKTFKVVKGYKATIQQTL--------DILFLQEGSEFLSStdastrd 299
Cdd:COG2319  153 KLLRTLTGHSGAVTSVAFSP---DGKLLASGSDDGTVRLWDLATGKLLRTLtghtgavrSVAFSPDGKLLASG------- 222

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979227 300 SADRTIIAWDFRTAAKISNQIFHERYTCpSLALHPrepvflaqtNGNYLALFSS-----VW-PYRMSRRRRYEGHKVEGY 373
Cdd:COG2319  223 SADGTVRLWDLATGKLLRTLTGHSGSVR-SVAFSP---------DGRLLASGSAdgtvrLWdLATGELLRTLTGHSGGVN 292

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568979227 374 AVgcECSPCGDLLVTGSADGRVLMFSFRTASRACTLQGHTQACLGTTYHPVlPSVLGTCSWGGDIKIWH 442
Cdd:COG2319  293 SV--AFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD-GKTLASGSDDGTVRLWD 358
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 233-399 5.92e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 63.12  E-value: 5.92e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979227 233 LRGHRGPVNSIQWCPVfckSHMLLSASMDKTFKVVKGYKATIQQTLD--------ILFLQEGSEFLSStdastrdSADRT 304
Cdd:cd00200  131 LRGHTDWVNSVAFSPD---GTFVASSSQDGTIKLWDLRTGKCVATLTghtgevnsVAFSPDGEKLLSS-------SSDGT 200

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979227 305 IIAWDFRTAAKISNQIFHERYtCPSLALHPrepvflaqtnGNYLALFSS------VWPYRM-SRRRRYEGHKVEGYAVGC 377
Cdd:cd00200  201 IKLWDLSTGKCLGTLRGHENG-VNSVAFSP----------DGYLLASGSedgtirVWDLRTgECVQTLSGHTNSVTSLAW 269

                        170       180
                 ....*....|....*....|..
gi 568979227 378 ecSPCGDLLVTGSADGRVLMFS 399
Cdd:cd00200  270 --SPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
228-441 3.17e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 61.47  E-value: 3.17e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979227 228 KVLFHLRGHRGPVNSIQWCPvfcKSHMLLSASMDKTFKVVKGYKATIQQTL--------DILFLQEGSEFLSStdastrd 299
Cdd:COG2319  111 LLLRTLTGHTGAVRSVAFSP---DGKTLASGSADGTVRLWDLATGKLLRTLtghsgavtSVAFSPDGKLLASG------- 180

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979227 300 SADRTIIAWDFRTAAKISNQIFHERYTCpSLALHPrepvflaqtNGNYLALFSS-----VW-PYRMSRRRRYEGHKVEGY 373
Cdd:COG2319  181 SDDGTVRLWDLATGKLLRTLTGHTGAVR-SVAFSP---------DGKLLASGSAdgtvrLWdLATGKLLRTLTGHSGSVR 250

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568979227 374 AVgcECSPCGDLLVTGSADGRVLMFSFRTASRACTLQGHTQACLGTTYHPVlPSVLGTCSWGGDIKIW 441
Cdd:COG2319  251 SV--AFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPD-GKLLASGSDDGTVRLW 315
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 354-442 8.71e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 50.41  E-value: 8.71e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979227 354 VWPY-RMSRRRRYEGHKVEgyAVGCECSPCGDLLVTGSADGRVLMFSFRTASRACTLQGHTQACLGTTYHPvLPSVLGTC 432
Cdd:cd00200   35 VWDLeTGELLRTLKGHTGP--VRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSP-DGRILSSS 111

                         90
                 ....*....|
gi 568979227 433 SWGGDIKIWH 442
Cdd:cd00200  112 SRDKTIKVWD 121
WD40 COG2319
WD40 repeat [General function prediction only];
289-441 3.32e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 49.14  E-value: 3.32e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979227 289 FLSSTDASTRDSADRTIIAWDFRTAAKISNQIFHERYTcPSLALHPrepvflaqtNGNYLALFSS-----VW-PYRMSRR 362
Cdd:COG2319   86 FSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAV-RSVAFSP---------DGKTLASGSAdgtvrLWdLATGKLL 155

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568979227 363 RRYEGHKVEGYAVgcECSPCGDLLVTGSADGRVLMFSFRTASRACTLQGHTQACLGTTYHPVlPSVLGTCSWGGDIKIW 441
Cdd:COG2319  156 RTLTGHSGAVTSV--AFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD-GKLLASGSADGTVRLW 231
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 226-266 3.31e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 3.31e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 568979227   226 PKKVLFHLRGHRGPVNSIQWCPvfcKSHMLLSASMDKTFKV 266
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP---DGKYLASGSDDGTIKL 38
WD40 COG2319
WD40 repeat [General function prediction only];
289-442 1.54e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 43.75  E-value: 1.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979227 289 FLSSTDASTRDSADRTIIAWDFRTAAKISNQIFHERYTcPSLALHPREPVFLAQTNGNYLALFSSVwpyRMSRRRRYEGH 368
Cdd:COG2319   44 ASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAV-LSVAFSPDGRLLASASADGTVRLWDLA---TGLLLRTLTGH 119

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568979227 369 KVEGYAVGCecSPCGDLLVTGSADGRVLMFSFRTASRACTLQGHTQACLGTTYHPVlPSVLGTCSWGGDIKIWH 442
Cdd:COG2319  120 TGAVRSVAF--SPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPD-GKLLASGSDDGTVRLWD 190
WD40 pfam00400
WD domain, G-beta repeat;
227-266 7.00e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 7.00e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 568979227  227 KKVLFHLRGHRGPVNSIQWCPvfcKSHMLLSASMDKTFKV 266
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSP---DGKLLASGSDDGTVKV 37
WD40 COG2319
WD40 repeat [General function prediction only];
228-312 5.35e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 38.74  E-value: 5.35e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979227 228 KVLFHLRGHRGPVNSIQWCPvfcKSHMLLSASMDKTFKVVKGYKATIQQTL--------DILFLQEGSEFLSStdastrd 299
Cdd:COG2319  321 KLLRTLTGHTGAVRSVAFSP---DGKTLASGSDDGTVRLWDLATGELLRTLtghtgavtSVAFSPDGRTLASG------- 390

                         90
                 ....*....|...
gi 568979227 300 SADRTIIAWDFRT 312
Cdd:COG2319  391 SADGTVRLWDLAT 403
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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