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Conserved domains on  [gi|568979225|ref|XP_006515724|]
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WD repeat-containing protein 25 isoform X2 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
228-358 7.56e-24

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 102.68  E-value: 7.56e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979225 228 KVLFHLRGHRGPVNSIQWCPvfcKSHMLLSASMDKTFKVWNaVDSGHCLQTYSVHSEAVRAARWSPCGRRILSGGFDFAL 307
Cdd:COG2319  195 KLLRTLTGHTGAVRSVAFSP---DGKLLASGSADGTVRLWD-LATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTV 270

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 568979225 308 HLTDLETGTQV--FSGQSDfRVTTLKFHPkDHNVFLCGGFSSEIKAWDMRTGK 358
Cdd:COG2319  271 RLWDLATGELLrtLTGHSG-GVNSVAFSP-DGKLLASGSDDGTVRLWDLATGK 321
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
228-358 7.56e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 102.68  E-value: 7.56e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979225 228 KVLFHLRGHRGPVNSIQWCPvfcKSHMLLSASMDKTFKVWNaVDSGHCLQTYSVHSEAVRAARWSPCGRRILSGGFDFAL 307
Cdd:COG2319  195 KLLRTLTGHTGAVRSVAFSP---DGKLLASGSADGTVRLWD-LATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTV 270

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 568979225 308 HLTDLETGTQV--FSGQSDfRVTTLKFHPkDHNVFLCGGFSSEIKAWDMRTGK 358
Cdd:COG2319  271 RLWDLATGELLrtLTGHSG-GVNSVAFSP-DGKLLASGSDDGTVRLWDLATGK 321
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 230-358 1.98e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 96.64  E-value: 1.98e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979225 230 LFHLRGHRGPVNSIQWCPVfckSHMLLSASMDKTFKVWNaVDSGHCLQTYSVHSEAVRAARWSPCGRRILSGGFDFALHL 309
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSPD---GKLLATGSGDGTIKVWD-LETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRL 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 568979225 310 TDLETG--TQVFSGQSDfRVTTLKFHPKDHnVFLCGGFSSEIKAWDMRTGK 358
Cdd:cd00200   78 WDLETGecVRTLTGHTS-YVSSVAFSPDGR-ILSSSSRDKTIKVWDVETGK 126
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 226-268 3.51e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.54  E-value: 3.51e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 568979225   226 PKKVLFHLRGHRGPVNSIQWCPvfcKSHMLLSASMDKTFKVWN 268
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP---DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
227-268 7.31e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 7.31e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 568979225  227 KKVLFHLRGHRGPVNSIQWCPvfcKSHMLLSASMDKTFKVWN 268
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSP---DGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 216-335 2.33e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 43.40  E-value: 2.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979225 216 LNSQYRETTVPKkvlfhLRGHRGPVNSIQWCPvfCKSHMLLSASMDKTFKVW---------NAVDSGHCLqtYSVHSEAV 286
Cdd:PTZ00420  58 LENQMRKPPVIK-----LKGHTSSILDLQFNP--CFSEILASGSEDLTIRVWeiphndesvKEIKDPQCI--LKGHKKKI 128

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 568979225 287 RAARWSPCGRRIL-SGGFDFALHLTDLETGTQVFSGQSDFRVTTLKFHPK 335
Cdd:PTZ00420 129 SIIDWNPMNYYIMcSSGFDSFVNIWDIENEKRAFQINMPKKLSSLKWNIK 178
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
228-358 7.56e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 102.68  E-value: 7.56e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979225 228 KVLFHLRGHRGPVNSIQWCPvfcKSHMLLSASMDKTFKVWNaVDSGHCLQTYSVHSEAVRAARWSPCGRRILSGGFDFAL 307
Cdd:COG2319  195 KLLRTLTGHTGAVRSVAFSP---DGKLLASGSADGTVRLWD-LATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTV 270

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 568979225 308 HLTDLETGTQV--FSGQSDfRVTTLKFHPkDHNVFLCGGFSSEIKAWDMRTGK 358
Cdd:COG2319  271 RLWDLATGELLrtLTGHSG-GVNSVAFSP-DGKLLASGSDDGTVRLWDLATGK 321
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 230-358 1.98e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 96.64  E-value: 1.98e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979225 230 LFHLRGHRGPVNSIQWCPVfckSHMLLSASMDKTFKVWNaVDSGHCLQTYSVHSEAVRAARWSPCGRRILSGGFDFALHL 309
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSPD---GKLLATGSGDGTIKVWD-LETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRL 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 568979225 310 TDLETG--TQVFSGQSDfRVTTLKFHPKDHnVFLCGGFSSEIKAWDMRTGK 358
Cdd:cd00200   78 WDLETGecVRTLTGHTS-YVSSVAFSPDGR-ILSSSSRDKTIKVWDVETGK 126
WD40 COG2319
WD40 repeat [General function prediction only];
228-358 2.63e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 98.44  E-value: 2.63e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979225 228 KVLFHLRGHRGPVNSIQWCPvfcKSHMLLSASMDKTFKVWNaVDSGHCLQTYSVHSEAVRAARWSPCGRRILSGGFDFAL 307
Cdd:COG2319  153 KLLRTLTGHSGAVTSVAFSP---DGKLLASGSDDGTVRLWD-LATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTV 228

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 568979225 308 HLTDLETGTQV--FSGQSDfRVTTLKFHPkDHNVFLCGGFSSEIKAWDMRTGK 358
Cdd:COG2319  229 RLWDLATGKLLrtLTGHSG-SVRSVAFSP-DGRLLASGSADGTVRLWDLATGE 279
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 228-358 7.77e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 95.09  E-value: 7.77e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979225 228 KVLFHLRGHRGPVNSIQWCPvfcKSHMLLSASMDKTFKVWNaVDSGHCLQTYSVHSEAVRAARWSPCGRRILSGGFDFAL 307
Cdd:cd00200   84 ECVRTLTGHTSYVSSVAFSP---DGRILSSSSRDKTIKVWD-VETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTI 159

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 568979225 308 HLTDLETGT--QVFSGQSDFrVTTLKFHPKDHNVFLCGGfSSEIKAWDMRTGK 358
Cdd:cd00200  160 KLWDLRTGKcvATLTGHTGE-VNSVAFSPDGEKLLSSSS-DGTIKLWDLSTGK 210
WD40 COG2319
WD40 repeat [General function prediction only];
228-358 1.00e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 93.82  E-value: 1.00e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979225 228 KVLFHLRGHRGPVNSIQWCPvfcKSHMLLSASMDKTFKVWNaVDSGHCLQTYSVHSEAVRAARWSPCGRRILSGGFDFAL 307
Cdd:COG2319  237 KLLRTLTGHSGSVRSVAFSP---DGRLLASGSADGTVRLWD-LATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTV 312

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 568979225 308 HLTDLETGTQV--FSGQSDfRVTTLKFHPkDHNVFLCGGFSSEIKAWDMRTGK 358
Cdd:COG2319  313 RLWDLATGKLLrtLTGHTG-AVRSVAFSP-DGKTLASGSDDGTVRLWDLATGE 363
WD40 COG2319
WD40 repeat [General function prediction only];
227-356 1.13e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 93.44  E-value: 1.13e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979225 227 KKVLFHLRGHRGPVNSIQWCPvfcKSHMLLSASMDKTFKVWNaVDSGHCLQTYSVHSEAVRAARWSPCGRRILSGGFDFA 306
Cdd:COG2319  278 GELLRTLTGHSGGVNSVAFSP---DGKLLASGSDDGTVRLWD-LATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGT 353

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 568979225 307 LHLTDLETGTQV--FSGQSDfRVTTLKFHPkDHNVFLCGGFSSEIKAWDMRT 356
Cdd:COG2319  354 VRLWDLATGELLrtLTGHTG-AVTSVAFSP-DGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 229-358 1.78e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 91.24  E-value: 1.78e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979225 229 VLFHLRGHRGPVNSIQWCpvfCKSHMLLSASMDKTFKVWNaVDSGHCLQTYSVHSEAVRAARWSPCGRRILSGGFDFALH 308
Cdd:cd00200   43 LLRTLKGHTGPVRDVAAS---ADGTYLASGSSDKTIRLWD-LETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIK 118

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 568979225 309 LTDLETGT--QVFSGQSDFrVTTLKFHPkDHNVFLCGGFSSEIKAWDMRTGK 358
Cdd:cd00200  119 VWDVETGKclTTLRGHTDW-VNSVAFSP-DGTFVASSSQDGTIKLWDLRTGK 168
WD40 COG2319
WD40 repeat [General function prediction only];
228-358 5.97e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 91.51  E-value: 5.97e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979225 228 KVLFHLRGHRGPVNSIQWCPvfcKSHMLLSASMDKTFKVWNaVDSGHCLQTYSVHSEAVRAARWSPCGRRILSGGFDFAL 307
Cdd:COG2319  111 LLLRTLTGHTGAVRSVAFSP---DGKTLASGSADGTVRLWD-LATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTV 186

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 568979225 308 HLTDLETGT--QVFSGQSDfRVTTLKFHPkDHNVFLCGGFSSEIKAWDMRTGK 358
Cdd:COG2319  187 RLWDLATGKllRTLTGHTG-AVRSVAFSP-DGKLLASGSADGTVRLWDLATGK 237
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 233-358 7.75e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 89.32  E-value: 7.75e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979225 233 LRGHRGPVNSIQWCPVfckSHMLLSASMDKTFKVWNaVDSGHCLQTYSVHSEAVRAARWSPCGRRILSGGFDFALHLTDL 312
Cdd:cd00200  131 LRGHTDWVNSVAFSPD---GTFVASSSQDGTIKLWD-LRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDL 206

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 568979225 313 ETGTQV--FSGQSDFrVTTLKFHPkDHNVFLCGGFSSEIKAWDMRTGK 358
Cdd:cd00200  207 STGKCLgtLRGHENG-VNSVAFSP-DGYLLASGSEDGTIRVWDLRTGE 252
WD40 COG2319
WD40 repeat [General function prediction only];
233-358 1.25e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 84.58  E-value: 1.25e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979225 233 LRGHRGPVNSIQWCPVfckSHMLLSASMDKTFKVWNaVDSGHCLQTYSVHSEAVRAARWSPCGRRILSGGFDFALHLTDL 312
Cdd:COG2319   74 LLGHTAAVLSVAFSPD---GRLLASASADGTVRLWD-LATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL 149

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 568979225 313 ETGT--QVFSGQSDfRVTTLKFHPkDHNVFLCGGFSSEIKAWDMRTGK 358
Cdd:COG2319  150 ATGKllRTLTGHSG-AVTSVAFSP-DGKLLASGSDDGTVRLWDLATGK 195
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 233-353 2.36e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 82.00  E-value: 2.36e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979225 233 LRGHRGPVNSIQWCPvfcKSHMLLSASMDKTFKVWNaVDSGHCLQTYSVHSEAVRAARWSPCGRRILSGGFDFALHLTDL 312
Cdd:cd00200  173 LTGHTGEVNSVAFSP---DGEKLLSSSSDGTIKLWD-LSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDL 248

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 568979225 313 ETGT--QVFSGQSDfRVTTLKFHPkDHNVFLCGGFSSEIKAWD 353
Cdd:cd00200  249 RTGEcvQTLSGHTN-SVTSLAWSP-DGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
229-358 1.89e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 56.07  E-value: 1.89e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979225 229 VLFHLRGHRGPVNSIQWCPVfckSHMLLSASMDKTFKVWNAvDSGHCLQTYSVHSEAVRAARWSPCGRRILSGGFDFALH 308
Cdd:COG2319   28 LLLLLLGLAAAVASLAASPD---GARLAAGAGDLTLLLLDA-AAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVR 103

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 568979225 309 LTDLETGT--QVFSGQSDfRVTTLKFHPkDHNVFLCGGFSSEIKAWDMRTGK 358
Cdd:COG2319  104 LWDLATGLllRTLTGHTG-AVRSVAFSP-DGKTLASGSADGTVRLWDLATGK 153
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 226-268 3.51e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.54  E-value: 3.51e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 568979225   226 PKKVLFHLRGHRGPVNSIQWCPvfcKSHMLLSASMDKTFKVWN 268
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP---DGKYLASGSDDGTIKLWD 40
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 275-358 2.03e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 49.26  E-value: 2.03e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979225 275 CLQTYSVHSEAVRAARWSPCGRRILSGGFDFALHLTDLETGTQV--FSGQSDFrVTTLKFHPkDHNVFLCGGFSSEIKAW 352
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLrtLKGHTGP-VRDVAASA-DGTYLASGSSDKTIRLW 78


                 ....*.
gi 568979225 353 DMRTGK 358
Cdd:cd00200   79 DLETGE 84
WD40 pfam00400
WD domain, G-beta repeat;
227-268 7.31e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 7.31e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 568979225  227 KKVLFHLRGHRGPVNSIQWCPvfcKSHMLLSASMDKTFKVWN 268
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSP---DGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 272-311 3.60e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 3.60e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 568979225   272 SGHCLQTYSVHSEAVRAARWSPCGRRILSGGFDFALHLTD 311
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00420 PTZ00420
coronin; Provisional
 216-335 2.33e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 43.40  E-value: 2.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979225 216 LNSQYRETTVPKkvlfhLRGHRGPVNSIQWCPvfCKSHMLLSASMDKTFKVW---------NAVDSGHCLqtYSVHSEAV 286
Cdd:PTZ00420  58 LENQMRKPPVIK-----LKGHTSSILDLQFNP--CFSEILASGSEDLTIRVWeiphndesvKEIKDPQCI--LKGHKKKI 128

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 568979225 287 RAARWSPCGRRIL-SGGFDFALHLTDLETGTQVFSGQSDFRVTTLKFHPK 335
Cdd:PTZ00420 129 SIIDWNPMNYYIMcSSGFDSFVNIWDIENEKRAFQINMPKKLSSLKWNIK 178
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 227-268 6.66e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 41.55  E-value: 6.66e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 568979225 227 KKVLFHLRGHRGPVNSIQWCPvfcKSHMLLSASMDKTFKVWN 268
Cdd:cd00200  251 GECVQTLSGHTNSVTSLAWSP---DGKRLASGSADGTIRIWD 289
WD40 pfam00400
WD domain, G-beta repeat;
273-311 9.67e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.55  E-value: 9.67e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 568979225  273 GHCLQTYSVHSEAVRAARWSPCGRRILSGGFDFALHLTD 311
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 230-355 1.36e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 41.03  E-value: 1.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979225 230 LFHLRGHRGPVNSIQWCPvfCKSHMLLSASMDKTFKVWNaVDSGHCLQTYSVHSEAVRAARWSPCGRRILSGGFDFALHL 309
Cdd:PTZ00421 118 IVHLQGHTKKVGIVSFHP--SAMNVLASAGADMVVNVWD-VERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNI 194

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 568979225 310 TDLETGTQVFSGQSDFRVTTLK-FHPKDHNVFLCGGFSS----EIKAWDMR 355
Cdd:PTZ00421 195 IDPRDGTIVSSVEAHASAKSQRcLWAKRKDLIITLGCSKsqqrQIMLWDTR 245
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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