TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 568978874   685 GTCTLPLVHRITKQICCCSRVGKAWGSTCEQCPLPGTEAFREIC 728
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTSVGRAWGSPCELCPPPGTDEFRELC 44

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 568978874  1558 DVCSQPLrGHHTTYTECCCQD-GEAWSQQCALCPPRSSEVYAQLC 1601
Cdd:pfam00683    1 GRCSNPL-PGNVTKSECCCTSvGRAWGSPCELCPPPGTDEFRELC 44

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|..
gi 568978874    938 DIDECEQPGVCS-GGRCSNTEGSYHCECDRGY 968
Cdd:smart00179    1 DIDECASGNPCQnGGTCVNTVGSYRCECPPGY 32

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|...
gi 568978874   1226 DVDECAATDPC-PGGHCVNTEGSFSCLCETGFQ 1257
Cdd:smart00179    1 DIDECASGNPCqNGGTCVNTVGSYRCECPPGYT 33

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568978874  895 DDNEC-MRNPCEGRGRCVNSVGSYSCLCYPGYTLVT 929
Cdd:cd00054     1 DIDECaSGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 568978874   1739 DVNECEDLNgpaaLCAHG-HCENTEGSYRCHCSPGY 1773
Cdd:smart00179    1 DIDECASGN----PCQNGgTCVNTVGSYRCECPPGY 32

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 568978874  978 DINECRHPGTC-PDGRCVNSPGSYTCLaCEEGYVGQS 1013
Cdd:cd00054     1 DIDECASGNPCqNGGTCVNTVGSYRCS-CPPGYTGRN 36

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 568978874   1059 DVDECASRASCPTG-LCLNTEGSFTCSaCQSGYwvnEDGTACE 1100
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCE-CPPGY---TDGRNCE 39

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 568978874   685 GTCTLPLVHRITKQICCCSRVGKAWGSTCEQCPLPGTEAFREIC 728
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTSVGRAWGSPCELCPPPGTDEFRELC 44

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 568978874  1558 DVCSQPLrGHHTTYTECCCQD-GEAWSQQCALCPPRSSEVYAQLC 1601
Cdd:pfam00683    1 GRCSNPL-PGNVTKSECCCTSvGRAWGSPCELCPPPGTDEFRELC 44

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                          10        20        30
                  ....*....|....*....|....*....|...
gi 568978874 1311 DIDECANDTVCGNHGFCDNTDGSFRCLCDQGFE 1343
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT 33

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|...
gi 568978874   1018 DVNECLTPGICTHG-RCINMEGSFRCSCEPGYE 1049
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT 33

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                          10        20        30
                  ....*....|....*....|....*....|...
gi 568978874  938 DIDECEQPGVCS-GGRCSNTEGSYHCECDRGYI 969
Cdd:cd00054     1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYT 33

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                          10        20        30
                  ....*....|....*....|....*....|...
gi 568978874 1226 DVDECAATDPC-PGGHCVNTEGSFSCLCETGFQ 1257
Cdd:cd00054     1 DIDECASGNPCqNGGTCVNTVGSYRCSCPPGYT 33

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 568978874  1226 DVDECA-ATDPCP-GGHCVNTEGSFSCLCETG 1255
Cdd:pfam07645    1 DVDECAtGTHNCPaNTVCVNTIGSFECRCPDG 32

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 568978874   1143 DVDECEGPQSSCRGGECKNTEGSYQCLCHQGFQlvNGTMCE 1183
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT--DGRNCE 39

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|...
gi 568978874    895 DDNEC-MRNPCEGRGRCVNSVGSYSCLCYPGYT 926
Cdd:smart00179    1 DIDECaSGNPCQNGGTCVNTVGSYRCECPPGYT 33

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 568978874 1184 DVNECVGEEHCAPHGECLNSLGSFFCLCAPGFAsaegGTRCQ 1225
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT----GRNCE 38

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 568978874  1311 DIDECANDT-VCGNHGFCDNTDGSFRCLCDQG 1341
Cdd:pfam07645    1 DVDECATGThNCPANTVCVNTIGSFECRCPDG 32

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568978874 1143 DVDECEGPQSSCRGGECKNTEGSYQCLCHQGFQLVN 1178
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                          10        20        30
                  ....*....|....*....|....*....|....*
gi 568978874  626 DINECLTLGLCK-DSECVNTRGSYLCTCRPGLMLD 659
Cdd:cd00054     1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYTGR 35

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568978874 1739 DVNECEDLNgpaaLCAHGH-CENTEGSYRCHCSPGY 1773
Cdd:cd00054     1 DIDECASGN----PCQNGGtCVNTVGSYRCSCPPGY 32

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|....*
gi 568978874  1739 DVNECEDlngPAALC-AHGHCENTEGSYRCHCSPG 1772
Cdd:pfam07645    1 DVDECAT---GTHNCpANTVCVNTIGSFECRCPDG 32

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|...
gi 568978874    978 DINECRHPGTC-PDGRCVNSPGSYTCLaCEEGY 1009
Cdd:smart00179    1 DIDECASGNPCqNGGTCVNTVGSYRCE-CPPGY 32

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 568978874   565 GQCANPL-GELTSQEDCCGSVGTFWGvTSCAPCPPR 599
Cdd:pfam00683    1 GRCSNPLpGNVTKSECCCTSVGRAWG-SPCELCPPP 35

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 568978874   685 GTCTLPLVHRITKQICCCSRVGKAWGSTCEQCPLPGTEAFREIC 728
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTSVGRAWGSPCELCPPPGTDEFRELC 44

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 568978874  1558 DVCSQPLrGHHTTYTECCCQD-GEAWSQQCALCPPRSSEVYAQLC 1601
Cdd:pfam00683    1 GRCSNPL-PGNVTKSECCCTSvGRAWGSPCELCPPPGTDEFRELC 44

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                          10        20        30
                  ....*....|....*....|....*....|...
gi 568978874 1311 DIDECANDTVCGNHGFCDNTDGSFRCLCDQGFE 1343
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT 33

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|...
gi 568978874   1018 DVNECLTPGICTHG-RCINMEGSFRCSCEPGYE 1049
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT 33

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                          10        20        30
                  ....*....|....*....|....*....|...
gi 568978874  938 DIDECEQPGVCS-GGRCSNTEGSYHCECDRGYI 969
Cdd:cd00054     1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYT 33

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                          10        20        30
                  ....*....|....*....|....*....|...
gi 568978874 1226 DVDECAATDPC-PGGHCVNTEGSFSCLCETGFQ 1257
Cdd:cd00054     1 DIDECASGNPCqNGGTCVNTVGSYRCSCPPGYT 33

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 568978874  1226 DVDECA-ATDPCP-GGHCVNTEGSFSCLCETG 1255
Cdd:pfam07645    1 DVDECAtGTHNCPaNTVCVNTIGSFECRCPDG 32

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 568978874   1143 DVDECEGPQSSCRGGECKNTEGSYQCLCHQGFQlvNGTMCE 1183
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT--DGRNCE 39

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|...
gi 568978874    895 DDNEC-MRNPCEGRGRCVNSVGSYSCLCYPGYT 926
Cdd:smart00179    1 DIDECaSGNPCQNGGTCVNTVGSYRCECPPGYT 33

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 568978874 1184 DVNECVGEEHCAPHGECLNSLGSFFCLCAPGFAsaegGTRCQ 1225
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT----GRNCE 38

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 568978874  1311 DIDECANDT-VCGNHGFCDNTDGSFRCLCDQG 1341
Cdd:pfam07645    1 DVDECATGThNCPANTVCVNTIGSFECRCPDG 32

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568978874 1143 DVDECEGPQSSCRGGECKNTEGSYQCLCHQGFQLVN 1178
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                          10        20        30
                  ....*....|....*....|....*....|....*
gi 568978874  626 DINECLTLGLCK-DSECVNTRGSYLCTCRPGLMLD 659
Cdd:cd00054     1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYTGR 35

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568978874 1739 DVNECEDLNgpaaLCAHGH-CENTEGSYRCHCSPGY 1773
Cdd:cd00054     1 DIDECASGN----PCQNGGtCVNTVGSYRCSCPPGY 32

Epidermal growth factor-like domain;

                            10        20
                    ....*....|....*....|....*....
gi 568978874   1021 ECLTPGICTHGRCINMEGSFRCSCEPGYE 1049
Cdd:smart00181    1 ECASGGPCSNGTCINTPGSYTCSCPPGYT 29

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 568978874   938 DIDECEQPG-VC-SGGRCSNTEGSYHCECDRG 967
Cdd:pfam07645    1 DVDECATGThNCpANTVCVNTIGSFECRCPDG 32

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 568978874 1101 DLDECAFPGVC-PTGVCTNTVGSFSCkDCDRGYRpnplGNRCE 1142
Cdd:cd00054     1 DIDECASGNPCqNGGTCVNTVGSYRC-SCPPGYT----GRNCE 38

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.

                          10        20        30
                  ....*....|....*....|....*....|
gi 568978874 1314 ECANDTVCGNHGFCDNTDGSFRCLCDQGFE 1343
Cdd:cd00053     1 ECAASNPCSNGGTCVNTPGSYRCVCPPGYT 30

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 568978874  1184 DVNECVGEEH-CAPHGECLNSLGSFFCLCAPG 1214
Cdd:pfam07645    1 DVDECATGTHnCPANTVCVNTIGSFECRCPDG 32