|
Name |
Accession |
Description |
Interval |
E-value |
| MT super family |
cl37598 |
Microtubule-binding stalk of dynein motor; the 380 kDa motor unit of dynein belongs to the AAA ... |
866-1210 |
5.72e-172 |
|
Microtubule-binding stalk of dynein motor; the 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This family is the region between D4 and D5 and is the two predicted alpha-helical coiled coil segments that form the stalk supporting the ATP-sensitive microtubule binding component.
The actual alignment was detected with superfamily member pfam12777:
Pssm-ID: 463699 [Multi-domain] Cd Length: 344 Bit Score: 530.03 E-value: 5.72e-172
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 866 EHLGNGIQKLQTTASQVGNLKSRLASQEAELQLRNLDAEALITKIGLQTEKVSREKAIADAEERKVAAIQTEASQKQREC 945
Cdd:pfam12777 1 ERLENGLLKLHSTAAQVDDLKAKLAAQEAELKQKNEDADKLIQVVGIEADKVSKEKAIADEEEQKVAVIMKEVKEKQKAC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 946 EADLLKAEPALVAAKDALNTLNRVNLTELKTFPNPPNAVTNVTAAVMVLLAPRGRVPKDRSWKAAKIFMGKVDDFLQALI 1025
Cdd:pfam12777 81 EEDLAKAEPALLAAQAALDTLNKNNLTELKSFGSPPDAVSNVSAAVMILMAPGGKIPKDKSWKAAKIMMAKVDGFLDSLI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 1026 NYDKEHIPENCLKVVnEQYLKDPEFNPNLIRTKSFAAAGLCAWVINIIRFYEVYCDVEPKRQALAQTNLDLAAATEKLEA 1105
Cdd:pfam12777 161 KFDKEHIHEACLKAF-KPYLGDPEFDPEFIASKSTAAAGLCSWCINIVRFYEVFCDVAPKRQALEEANADLAAAQEKLAA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 1106 VRRKLVDLDHNLSRLTASFEKATAEKVRCQEEVNQTNKTIDLANKLVSELESEKIRWGQSIKSFETQEKTLCGDVLLTAA 1185
Cdd:pfam12777 240 IKAKIAELNANLAKLTAAFEKATADKIKCQQEADATARTILLANRLVGGLASENIRWADAVENFKQQERTLCGDILLISA 319
|
330 340
....*....|....*....|....*
gi 568978793 1186 FVSYIGSFTRQYRQELVDCKWIPFL 1210
Cdd:pfam12777 320 FISYLGFFTKKYRNELLDKFWIPYI 344
|
|
| Dynein_C |
pfam18199 |
Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein ... |
1988-2283 |
3.07e-123 |
|
Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein heavy chain. This domain is a complex structure comprising six alpha-helices and an incomplete six-stranded antiparallel beta-barrel. The shape of this domain is distinctively flat, spreading over the AAA1, AAA5 and AAA6 domain.
:
Pssm-ID: 465677 Cd Length: 301 Bit Score: 390.83 E-value: 3.07e-123
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 1988 TVTSNTLFRTLLEMQPRNAVSQEELGQSTEDKVKNILDDILERLPEEFNMAEIMQKNP--NRSPYVLVCFQECERMNVLI 2065
Cdd:pfam18199 1 TNETNELLSTLLSLQPRSDSGGGGGGSSREEIVLELAKDILEKLPEPFDIEEAEEKYPvgYEDPLNTVLLQEIERFNKLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 2066 REIRVSLQHLDLGLKGELTLSPDVETQLSALSYDRVPDTWNKLAYPSTYGLAQWFNDLLLRCRELDTWTQDLTLPAVVWL 2145
Cdd:pfam18199 81 KVIRRSLQDLQKAIKGLVVMSSELEELANSLLNGKVPESWAKKSYPSLKPLGSWIRDLLERLKQLQDWLDDEGPPKVFWL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 2146 SGFFNPQSFLTAIMQTMARKNEWPLDRMCLTIDVTKK-TKEDYGHPPREGAYLHGLHLEGARWDIQSGALVDARLKELTS 2224
Cdd:pfam18199 161 SGFFFPQAFLTAVLQNYARKNGWPIDKLSFDFEVTKKvSPEEVTEPPEDGVYVHGLFLEGARWDRKNGCLVESEPKELFS 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568978793 2225 MMPVIFAKAVPVDRQEIKHA-YECPVYKTKARG-PTYVWTFRLRSKDRIAKWVLAGVALLL 2283
Cdd:pfam18199 241 PLPVIHLKPVESDKKKLDENtYECPVYKTSERHsTNFVFSVDLPTDKPPDHWILRGVALLL 301
|
|
| AAA_9 |
pfam12781 |
ATP-binding dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. ... |
1235-1453 |
1.06e-111 |
|
ATP-binding dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities (AAA1-AAA6). This is the fifth AAA+ domain subdomain AAA5S. Structural analysis reveal that it is the coiled-coil buttress interface. The relative movement of AAA5S together with the stalk (AAA4S), is coupled to rearrangements in the AAA+ ring. Closure of the AAA1 site and the rigid body movement of AAA2-AAA4 force the AAA4/AAA5 interface to close and the AAA6L subdomain to rotate towards the ring centre. The AAA5S subdomain rotates as a unit together with AAA6L, and this movement pulls the buttress relative to the stalk.
:
Pssm-ID: 463702 [Multi-domain] Cd Length: 222 Bit Score: 354.44 E-value: 1.06e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 1235 ATWNNEGLPSDRMSTENATILTHCERWPLMIDPQQQGIKWIKNKYGP-DLKVTHLGQKGFLNTIETALAFGDVILIENLK 1313
Cdd:pfam12781 1 REWNIQGLPNDELSIENAIIVTNSRRWPLLIDPQGQANKWIKNMEKDnGLKVTSFTDKNFLKTLENAIRFGKPLLIEDVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 1314 ETVDPVLGPLLGRNTTKKG--KFIRIGDKECEFNKNFRLILHTKLANPHYKPELQAQTTLLNFTVTEDGLEGQLLAEVVS 1391
Cdd:pfam12781 81 EELDPILDPVLLKEIFKGGgrKVIKLGDKEVDYNPNFRLYLTTKLPNPHYPPEVAAKVTLINFTVTRSGLEDQLLGIVVK 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568978793 1392 IERPDLERLKLVLTKQQNDFKIELRQLEDDLLLRLSAAEGSFLDDTDLVERLETTKATAAEI 1453
Cdd:pfam12781 161 KERPDLEEQRNELIKEIAENKKQLKELEDKLLELLSSSEGNILDDEELIETLETSKKTSEEI 222
|
|
| AAA_8 |
pfam12780 |
P-loop containing dynein motor region D4; The 380 kDa motor unit of dynein belongs to the AAA ... |
594-853 |
4.59e-110 |
|
P-loop containing dynein motor region D4; The 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This particular family is the D4 ATP-binding region of the motor.
:
Pssm-ID: 463701 [Multi-domain] Cd Length: 259 Bit Score: 351.14 E-value: 4.59e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 594 MHLVLFEDAMQHVCRISRILRIPQGHALLIGVGGSGKQSLSRLAAYICSLEVFQITLTEGYGAQELRVDLANLYVRTGAK 673
Cdd:pfam12780 1 MDLVLFRDALEHLCRICRILRQPRGHALLVGVGGSGRQSLTKLAAFIAGYELFQIEVTRNYDMNEFREDLKKVLKKAGIK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 674 NMPTVFLLTDAHVLDESFLVLINDLLASGDIPDLFSDEDMDKIISGIRNEVRGLGLVDSRENCWAFFLARVRQQLKMVFC 753
Cdd:pfam12780 81 GKPTVFLLSDTQIIEESFLEDINNLLNSGEVPNLFTDEEKEEIIESVRDDAKAQNIEDSREAVYNYFVKRCRNNLHIVLC 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 754 FSPVGHTLRVRARKFPAIVNCTAIDWFHEWPQEALVSVSRRFIEEIEGIEpQHKDSISLFMAHVHTSVKEVSAWYYQNER 833
Cdd:pfam12780 161 MSPVGEAFRNRLRMFPSLVNCCTIDWFNEWPEEALLAVAEKFLEDIEIPE-ELKSNVVKVFVYVHSSVEDMSKKFYEELK 239
|
250 260
....*....|....*....|
gi 568978793 834 RYNYTTPRSFLEQISLFKSL 853
Cdd:pfam12780 240 RKNYVTPKSYLELLRLYKNL 259
|
|
| DYN1 super family |
cl34955 |
Dynein, heavy chain [Cytoskeleton]; |
5-1935 |
5.12e-97 |
|
Dynein, heavy chain [Cytoskeleton];
The actual alignment was detected with superfamily member COG5245:
Pssm-ID: 227570 [Multi-domain] Cd Length: 3164 Bit Score: 351.98 E-value: 5.12e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 5 GLFSSILREQANLT-HDGPTWIVLDGdidplWIESLNTVMDDNKVLTLASNERvalkpsmRLLFEThhlRTATPATVSRA 83
Cdd:COG5245 1227 QFFLMFNREDMEARlADSKMEYEVER-----YVEKTKAEVSSLKLELSSVGEG-------QVVVSN---LGSIGDKVGRC 1291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 84 GILY----------VNPQDLG-WNPYVASWIDRRRHQSEKANLTILFDK-YIPVCLE---------KLRTSFKAITSVPE 142
Cdd:COG5245 1292 LVEYdsisrlstkgVFLDELGdTKRYLDECLDFFSCFEEVQKEIDELSMvFCADALRfsadlyhivKERRFSGVLAGSDA 1371
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 143 S-SLVQTICTLLECLLTPENIppDSPKETYEVYFAFACvwtFGGTLLRDQLSDYQ---ADFSrwwhKEMKAVKFPSQGTI 218
Cdd:COG5245 1372 SeSLGGKSIELAAILEHKDLI--VEMKRGINDVLKLRI---FGDKCRESTPRFYLisdGDLI----KDLNERSDYEEMLI 1442
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 219 FDYYLDHKTKKFLPwtdkVPQFSMDADAPL--KTVLVHTPETTRLRYFTELLLCKGKPIMLVGNAGVGKTVFLSNTLASl 296
Cdd:COG5245 1443 MMFNISAVITNNGS----IAGFELRGERVMlrKEVVIPTSDTGFVDSFSNEALNTLRSYIYCGPPGSGKEMLMCPSLRS- 1517
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 297 SENYIVSCVPFNYYTTSAALQRILEKPLEKKagRNYG-----PKGN-KKLVYFIDDLNMPEVDLYGTIQPHALLRQHIDY 370
Cdd:COG5245 1518 ELITEVKYFNFSTCTMTPSKLSVLERETEYY--PNTGvvrlyPKPVvKDLVLFCDEINLPYGFEYYPPTVIVFLRPLVER 1595
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 371 -GHWYDRHKiMLKEIRNCQYVACMNP--MVGSFTVNPRLQRHfTVFAF-NFPSLDALTTIYgqifSFYLQQQAFC-PSVL 445
Cdd:COG5245 1596 qGFWSSIAV-SWVTICGIILYGACNPgtDEGRVKYYERFIRK-PVFVFcCYPELASLRNIY----EAVLMGSYLCfDEFN 1669
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 446 RAGPSLIQATIAFHQMMAESFvPTAIKFHYNFNLRDLSNIFQGIL-FASPECLKSLEDLARLWLHETSRVYGDRLIDTND 524
Cdd:COG5245 1670 RLSEETMSASVELYLSSKDKT-KFFLQMNYGYKPRELTRSLRAIFgYAETRIDTPDVSLIIDWYCEAIREKIDRLVQQKE 1748
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 525 FDLFQRKMLETAHKYFKGVDANALLRQPLVYCHFASGGedpcyMPVKDWEGLKAVLMEMVDNYNELHSAMHLVLFEDAMQ 604
Cdd:COG5245 1749 SSTSRQDLYDFGLRAIREMIAGHIGEAEITFSMILFFG-----MACLLKKDLAVFVEEVRKIFGSSHLDVEAVAYKDALL 1823
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 605 HVCRISRILRIPQGHALLIGVGGSGKQSLSRLAAYICSLEVFQITLTEGYGAQELRVDLANLYVRTGAKNMPTVFLLTDA 684
Cdd:COG5245 1824 HILRSRRGLLVVGGHGVLKGVLIRGACDAREFVCWLNPRNMREIFGHRDELTGDFRDSLKVQDLRRNIHGGRECLFIFES 1903
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 685 HVLDESFLVLINDLLASGDIPDLFSDEDMDKIISGIRNEVRGLGL-VDSRENCWAFFLARVRQQLKMVFCFSPVGHTLRV 763
Cdd:COG5245 1904 IPVESSFLEDFNPLLDNNRFLCLFSGNERIRIPENLRFVFESTSLeKDTEATLTRVFLVYMEENLPVVFSACCSQDTSVL 1983
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 764 RARKFPAIVNCTAIDWFHEWPQEALVSVSRRFI-EEIEGIEPQH--------KDSISLFMAHVHTSVKEVSAWYYQNERR 834
Cdd:COG5245 1984 AGIRSPALKNRCFIDFKKLWDTEEMSQYANSVEtLSRDGGRVFFingelgvgKGALISEVFGDDAVVIEGRGFEISMIEG 2063
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 835 YNYTTPRSFLEQISLFKSLLKKKREEVKQKQEHLGNGIQKLQTTASQVGNLKSRLASQEAELQLRNLDAEALITKIgLQT 914
Cdd:COG5245 2064 SLGESKIKFIGGLKVYDARCVIYIEELDCTNVNLVEGVRKYNEYGRGMGELKEQLSNTVVILGVKEKNADDALSGT-PGE 2142
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 915 EKVSREKAIADAEERKVAAIQTEASQKQRECEADLLK-AEPALVAAKDALNTLNRVNLTELKTFPNPPNAVTNVTAAVMV 993
Cdd:COG5245 2143 RLEREVKSVFVEAPRDMLFLLEEEVRKRKGSVMKFKSsKKPAVLEAVLFVYKIKKASLREIRSFIRPPGDLCIEMEDVCD 2222
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 994 LLaprGRVPKDrsWKAAKIFMgKVDDFLQALINYDKE-HIPENCLKVVNEQYLKDPEFNPNLIRTKSFAAAGLCAWVINI 1072
Cdd:COG5245 2223 LL---GFEAKI--WFGEQQSL-RRDDFIRIIGKYPDEiEFDLEARRFREARECSDPSFTGSILNRASKACGPLKRWLVRE 2296
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 1073 IRFYEVYCDVEPKRQALAQTNLDLAAATEKLEAVRRKLVDLDHNLSRLTASFEKATAEKVRCQEEVNQTNKTIDLANKLV 1152
Cdd:COG5245 2297 CNRSKVLEVKIPLREEEKRIDGEAFLVEDRLTLGKGLSSDLMTFKLRRRSYYSLDILRVHGKIADMDTVHKDVLRSIFVS 2376
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 1153 SELESEKIRWGQSIKSFETQEKTLCGDVLLTAAFVSYIGSFTRQYRQ-ELVDCKwiPFLQQKVSIP-------IAEGLDL 1224
Cdd:COG5245 2377 EILINEDSEWGGVFSEVPKLMVELDGDGHPSSCLHPYIGTLGFLCRAiEFGMSF--IRISKEFRDKeirrrqfITEGVQK 2454
|
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 1225 IamlTDDATIATWNNEGLPSDRMSTENATILthcerwPLMIDPQQQGIKWIKNKYGPdlKVTHLG---QKGFLNTIETAL 1301
Cdd:COG5245 2455 I---EDFKEEACSTDYGLENSRIRKDLQDLT------AVLNDPSSKIVTSQRQMYDE--KKAILGsfrEMEFAFGLSQAR 2523
|
1370 1380 1390 1400 1410 1420 1430 1440
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 1302 AFGDVILIENlKETVDPVLGPLLGRNTTKKGKFIR--IGDKECEFNKNFRLILHTKLANPHYKPELQAQTTLLNFTVTED 1379
Cdd:COG5245 2524 REGSDKIIGD-AEALDEEIGRLIKEEFKSNLSEVKvmINPPEIVRSTVEAVFWLSEGRSGDMGSIEWKQLIQVMFVSKVL 2602
|
1450 1460 1470 1480 1490 1500 1510 1520
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 1380 GLEGQLLAEVVSIERPDLERLKLVLTKQQNDFKIELRQLEDDLLLRLSAAEGSFLDDTDLVERLETTKATAAEIEHKVTE 1459
Cdd:COG5245 2603 GCETEIPDALEKLVSGPLFVHEKALNALKACGSLFLWVLARYLLAKLMLSISNMEQTDEIAVLLHNLKKSRKEIEEEESE 2682
|
1530 1540 1550 1560 1570 1580 1590 1600
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 1460 ARENERKINETRECYRPVAARASLLYFVISDLRRINPVYQFSLKAFNTLFHRaieqadkVEDTQERICALIESITHATFL 1539
Cdd:COG5245 2683 SMEIEDRIDALKSEYNASVKRLESIRVEIAMFDEKALMYNKSICELSSEFEK-------WRRMKSKYLCAIRYMLMSSEW 2755
|
1610 1620 1630 1640 1650 1660 1670 1680
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 1540 YasqaLFERDKLTFlsqmafqillrrneIHPLELDFLLRFTVEHTYSSPVDFLTAQSWSAVkavalmeeFRGLDRDVEGS 1619
Cdd:COG5245 2756 I----LDHEDRSGF--------------IHRLDVSFLLRTKRFVSTLLEDKNYRQVLSSCS--------LYGNDVISHSC 2809
|
1690 1700 1710 1720 1730 1740 1750 1760
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 1620 AKQWRKWVESEcpekeklpqewKKKSLIQKLIILRAVRPDRMTYALRNFVEEKLGAKYVERT--RLDLGKAFEESSPST- 1696
Cdd:COG5245 2810 DRFDRDVYRAL-----------KHQMDNRTHSTILTSNSKTNPYKEYTYNDSWAEAFEVEDSgdLYKFEEGLLELIVGHa 2878
|
1770 1780 1790 1800 1810 1820 1830 1840
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 1697 PVFFILSPGVDALKDLEVLG--KRLGFTIDSGKFHNVSlgqgqelvaemamekaaagGHWVILQNVHLVAKWlgtLEKLL 1774
Cdd:COG5245 2879 PLIYAHKKSLENERNVDRLGskENEVYAVLNSLFSRKE-------------------KSWFEVYNISLSFGW---FKRYV 2936
|
1850 1860 1870 1880 1890 1900 1910 1920
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 1775 EKFSQGS-----HRDYRVFLSAETVPSQhepiIPQGLLENSIKITNEPPTGMLANLhAALYNFDQ---DTLEMCSKDqef 1846
Cdd:COG5245 2937 EDVVYPIkasrvCGKVKNMWTSMVDADM----LPIQLLIAIDSFVSSTYPETGCGY-ADLVEIDRypfDYTLVIACD--- 3008
|
1930 1940 1950 1960 1970 1980 1990 2000
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 1847 ksILFSLCYFHACVAGRLRFGPQGWSRSYPFSPGDLTICTNILYNYLEANP--NVPWEDLRYLFGEIMYGGHITDAWD-- 1922
Cdd:COG5245 3009 --DAFYLSWEHAAVASVISAGPKENNEEIYFGDKDFEFKTHLLKNILFLNHlnARKWGNNRDLIFTIVYGKKHSLMEDsk 3086
|
2010
....*....|....*
gi 568978793 1923 --RKLCRVYLEEFMN 1935
Cdd:COG5245 3087 vvDKYCRGYGAHETS 3101
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| MT |
pfam12777 |
Microtubule-binding stalk of dynein motor; the 380 kDa motor unit of dynein belongs to the AAA ... |
866-1210 |
5.72e-172 |
|
Microtubule-binding stalk of dynein motor; the 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This family is the region between D4 and D5 and is the two predicted alpha-helical coiled coil segments that form the stalk supporting the ATP-sensitive microtubule binding component.
Pssm-ID: 463699 [Multi-domain] Cd Length: 344 Bit Score: 530.03 E-value: 5.72e-172
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 866 EHLGNGIQKLQTTASQVGNLKSRLASQEAELQLRNLDAEALITKIGLQTEKVSREKAIADAEERKVAAIQTEASQKQREC 945
Cdd:pfam12777 1 ERLENGLLKLHSTAAQVDDLKAKLAAQEAELKQKNEDADKLIQVVGIEADKVSKEKAIADEEEQKVAVIMKEVKEKQKAC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 946 EADLLKAEPALVAAKDALNTLNRVNLTELKTFPNPPNAVTNVTAAVMVLLAPRGRVPKDRSWKAAKIFMGKVDDFLQALI 1025
Cdd:pfam12777 81 EEDLAKAEPALLAAQAALDTLNKNNLTELKSFGSPPDAVSNVSAAVMILMAPGGKIPKDKSWKAAKIMMAKVDGFLDSLI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 1026 NYDKEHIPENCLKVVnEQYLKDPEFNPNLIRTKSFAAAGLCAWVINIIRFYEVYCDVEPKRQALAQTNLDLAAATEKLEA 1105
Cdd:pfam12777 161 KFDKEHIHEACLKAF-KPYLGDPEFDPEFIASKSTAAAGLCSWCINIVRFYEVFCDVAPKRQALEEANADLAAAQEKLAA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 1106 VRRKLVDLDHNLSRLTASFEKATAEKVRCQEEVNQTNKTIDLANKLVSELESEKIRWGQSIKSFETQEKTLCGDVLLTAA 1185
Cdd:pfam12777 240 IKAKIAELNANLAKLTAAFEKATADKIKCQQEADATARTILLANRLVGGLASENIRWADAVENFKQQERTLCGDILLISA 319
|
330 340
....*....|....*....|....*
gi 568978793 1186 FVSYIGSFTRQYRQELVDCKWIPFL 1210
Cdd:pfam12777 320 FISYLGFFTKKYRNELLDKFWIPYI 344
|
|
| Dynein_C |
pfam18199 |
Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein ... |
1988-2283 |
3.07e-123 |
|
Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein heavy chain. This domain is a complex structure comprising six alpha-helices and an incomplete six-stranded antiparallel beta-barrel. The shape of this domain is distinctively flat, spreading over the AAA1, AAA5 and AAA6 domain.
Pssm-ID: 465677 Cd Length: 301 Bit Score: 390.83 E-value: 3.07e-123
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 1988 TVTSNTLFRTLLEMQPRNAVSQEELGQSTEDKVKNILDDILERLPEEFNMAEIMQKNP--NRSPYVLVCFQECERMNVLI 2065
Cdd:pfam18199 1 TNETNELLSTLLSLQPRSDSGGGGGGSSREEIVLELAKDILEKLPEPFDIEEAEEKYPvgYEDPLNTVLLQEIERFNKLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 2066 REIRVSLQHLDLGLKGELTLSPDVETQLSALSYDRVPDTWNKLAYPSTYGLAQWFNDLLLRCRELDTWTQDLTLPAVVWL 2145
Cdd:pfam18199 81 KVIRRSLQDLQKAIKGLVVMSSELEELANSLLNGKVPESWAKKSYPSLKPLGSWIRDLLERLKQLQDWLDDEGPPKVFWL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 2146 SGFFNPQSFLTAIMQTMARKNEWPLDRMCLTIDVTKK-TKEDYGHPPREGAYLHGLHLEGARWDIQSGALVDARLKELTS 2224
Cdd:pfam18199 161 SGFFFPQAFLTAVLQNYARKNGWPIDKLSFDFEVTKKvSPEEVTEPPEDGVYVHGLFLEGARWDRKNGCLVESEPKELFS 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568978793 2225 MMPVIFAKAVPVDRQEIKHA-YECPVYKTKARG-PTYVWTFRLRSKDRIAKWVLAGVALLL 2283
Cdd:pfam18199 241 PLPVIHLKPVESDKKKLDENtYECPVYKTSERHsTNFVFSVDLPTDKPPDHWILRGVALLL 301
|
|
| AAA_9 |
pfam12781 |
ATP-binding dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. ... |
1235-1453 |
1.06e-111 |
|
ATP-binding dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities (AAA1-AAA6). This is the fifth AAA+ domain subdomain AAA5S. Structural analysis reveal that it is the coiled-coil buttress interface. The relative movement of AAA5S together with the stalk (AAA4S), is coupled to rearrangements in the AAA+ ring. Closure of the AAA1 site and the rigid body movement of AAA2-AAA4 force the AAA4/AAA5 interface to close and the AAA6L subdomain to rotate towards the ring centre. The AAA5S subdomain rotates as a unit together with AAA6L, and this movement pulls the buttress relative to the stalk.
Pssm-ID: 463702 [Multi-domain] Cd Length: 222 Bit Score: 354.44 E-value: 1.06e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 1235 ATWNNEGLPSDRMSTENATILTHCERWPLMIDPQQQGIKWIKNKYGP-DLKVTHLGQKGFLNTIETALAFGDVILIENLK 1313
Cdd:pfam12781 1 REWNIQGLPNDELSIENAIIVTNSRRWPLLIDPQGQANKWIKNMEKDnGLKVTSFTDKNFLKTLENAIRFGKPLLIEDVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 1314 ETVDPVLGPLLGRNTTKKG--KFIRIGDKECEFNKNFRLILHTKLANPHYKPELQAQTTLLNFTVTEDGLEGQLLAEVVS 1391
Cdd:pfam12781 81 EELDPILDPVLLKEIFKGGgrKVIKLGDKEVDYNPNFRLYLTTKLPNPHYPPEVAAKVTLINFTVTRSGLEDQLLGIVVK 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568978793 1392 IERPDLERLKLVLTKQQNDFKIELRQLEDDLLLRLSAAEGSFLDDTDLVERLETTKATAAEI 1453
Cdd:pfam12781 161 KERPDLEEQRNELIKEIAENKKQLKELEDKLLELLSSSEGNILDDEELIETLETSKKTSEEI 222
|
|
| AAA_8 |
pfam12780 |
P-loop containing dynein motor region D4; The 380 kDa motor unit of dynein belongs to the AAA ... |
594-853 |
4.59e-110 |
|
P-loop containing dynein motor region D4; The 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This particular family is the D4 ATP-binding region of the motor.
Pssm-ID: 463701 [Multi-domain] Cd Length: 259 Bit Score: 351.14 E-value: 4.59e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 594 MHLVLFEDAMQHVCRISRILRIPQGHALLIGVGGSGKQSLSRLAAYICSLEVFQITLTEGYGAQELRVDLANLYVRTGAK 673
Cdd:pfam12780 1 MDLVLFRDALEHLCRICRILRQPRGHALLVGVGGSGRQSLTKLAAFIAGYELFQIEVTRNYDMNEFREDLKKVLKKAGIK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 674 NMPTVFLLTDAHVLDESFLVLINDLLASGDIPDLFSDEDMDKIISGIRNEVRGLGLVDSRENCWAFFLARVRQQLKMVFC 753
Cdd:pfam12780 81 GKPTVFLLSDTQIIEESFLEDINNLLNSGEVPNLFTDEEKEEIIESVRDDAKAQNIEDSREAVYNYFVKRCRNNLHIVLC 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 754 FSPVGHTLRVRARKFPAIVNCTAIDWFHEWPQEALVSVSRRFIEEIEGIEpQHKDSISLFMAHVHTSVKEVSAWYYQNER 833
Cdd:pfam12780 161 MSPVGEAFRNRLRMFPSLVNCCTIDWFNEWPEEALLAVAEKFLEDIEIPE-ELKSNVVKVFVYVHSSVEDMSKKFYEELK 239
|
250 260
....*....|....*....|
gi 568978793 834 RYNYTTPRSFLEQISLFKSL 853
Cdd:pfam12780 240 RKNYVTPKSYLELLRLYKNL 259
|
|
| DYN1 |
COG5245 |
Dynein, heavy chain [Cytoskeleton]; |
5-1935 |
5.12e-97 |
|
Dynein, heavy chain [Cytoskeleton];
Pssm-ID: 227570 [Multi-domain] Cd Length: 3164 Bit Score: 351.98 E-value: 5.12e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 5 GLFSSILREQANLT-HDGPTWIVLDGdidplWIESLNTVMDDNKVLTLASNERvalkpsmRLLFEThhlRTATPATVSRA 83
Cdd:COG5245 1227 QFFLMFNREDMEARlADSKMEYEVER-----YVEKTKAEVSSLKLELSSVGEG-------QVVVSN---LGSIGDKVGRC 1291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 84 GILY----------VNPQDLG-WNPYVASWIDRRRHQSEKANLTILFDK-YIPVCLE---------KLRTSFKAITSVPE 142
Cdd:COG5245 1292 LVEYdsisrlstkgVFLDELGdTKRYLDECLDFFSCFEEVQKEIDELSMvFCADALRfsadlyhivKERRFSGVLAGSDA 1371
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 143 S-SLVQTICTLLECLLTPENIppDSPKETYEVYFAFACvwtFGGTLLRDQLSDYQ---ADFSrwwhKEMKAVKFPSQGTI 218
Cdd:COG5245 1372 SeSLGGKSIELAAILEHKDLI--VEMKRGINDVLKLRI---FGDKCRESTPRFYLisdGDLI----KDLNERSDYEEMLI 1442
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 219 FDYYLDHKTKKFLPwtdkVPQFSMDADAPL--KTVLVHTPETTRLRYFTELLLCKGKPIMLVGNAGVGKTVFLSNTLASl 296
Cdd:COG5245 1443 MMFNISAVITNNGS----IAGFELRGERVMlrKEVVIPTSDTGFVDSFSNEALNTLRSYIYCGPPGSGKEMLMCPSLRS- 1517
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 297 SENYIVSCVPFNYYTTSAALQRILEKPLEKKagRNYG-----PKGN-KKLVYFIDDLNMPEVDLYGTIQPHALLRQHIDY 370
Cdd:COG5245 1518 ELITEVKYFNFSTCTMTPSKLSVLERETEYY--PNTGvvrlyPKPVvKDLVLFCDEINLPYGFEYYPPTVIVFLRPLVER 1595
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 371 -GHWYDRHKiMLKEIRNCQYVACMNP--MVGSFTVNPRLQRHfTVFAF-NFPSLDALTTIYgqifSFYLQQQAFC-PSVL 445
Cdd:COG5245 1596 qGFWSSIAV-SWVTICGIILYGACNPgtDEGRVKYYERFIRK-PVFVFcCYPELASLRNIY----EAVLMGSYLCfDEFN 1669
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 446 RAGPSLIQATIAFHQMMAESFvPTAIKFHYNFNLRDLSNIFQGIL-FASPECLKSLEDLARLWLHETSRVYGDRLIDTND 524
Cdd:COG5245 1670 RLSEETMSASVELYLSSKDKT-KFFLQMNYGYKPRELTRSLRAIFgYAETRIDTPDVSLIIDWYCEAIREKIDRLVQQKE 1748
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 525 FDLFQRKMLETAHKYFKGVDANALLRQPLVYCHFASGGedpcyMPVKDWEGLKAVLMEMVDNYNELHSAMHLVLFEDAMQ 604
Cdd:COG5245 1749 SSTSRQDLYDFGLRAIREMIAGHIGEAEITFSMILFFG-----MACLLKKDLAVFVEEVRKIFGSSHLDVEAVAYKDALL 1823
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 605 HVCRISRILRIPQGHALLIGVGGSGKQSLSRLAAYICSLEVFQITLTEGYGAQELRVDLANLYVRTGAKNMPTVFLLTDA 684
Cdd:COG5245 1824 HILRSRRGLLVVGGHGVLKGVLIRGACDAREFVCWLNPRNMREIFGHRDELTGDFRDSLKVQDLRRNIHGGRECLFIFES 1903
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 685 HVLDESFLVLINDLLASGDIPDLFSDEDMDKIISGIRNEVRGLGL-VDSRENCWAFFLARVRQQLKMVFCFSPVGHTLRV 763
Cdd:COG5245 1904 IPVESSFLEDFNPLLDNNRFLCLFSGNERIRIPENLRFVFESTSLeKDTEATLTRVFLVYMEENLPVVFSACCSQDTSVL 1983
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 764 RARKFPAIVNCTAIDWFHEWPQEALVSVSRRFI-EEIEGIEPQH--------KDSISLFMAHVHTSVKEVSAWYYQNERR 834
Cdd:COG5245 1984 AGIRSPALKNRCFIDFKKLWDTEEMSQYANSVEtLSRDGGRVFFingelgvgKGALISEVFGDDAVVIEGRGFEISMIEG 2063
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 835 YNYTTPRSFLEQISLFKSLLKKKREEVKQKQEHLGNGIQKLQTTASQVGNLKSRLASQEAELQLRNLDAEALITKIgLQT 914
Cdd:COG5245 2064 SLGESKIKFIGGLKVYDARCVIYIEELDCTNVNLVEGVRKYNEYGRGMGELKEQLSNTVVILGVKEKNADDALSGT-PGE 2142
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 915 EKVSREKAIADAEERKVAAIQTEASQKQRECEADLLK-AEPALVAAKDALNTLNRVNLTELKTFPNPPNAVTNVTAAVMV 993
Cdd:COG5245 2143 RLEREVKSVFVEAPRDMLFLLEEEVRKRKGSVMKFKSsKKPAVLEAVLFVYKIKKASLREIRSFIRPPGDLCIEMEDVCD 2222
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 994 LLaprGRVPKDrsWKAAKIFMgKVDDFLQALINYDKE-HIPENCLKVVNEQYLKDPEFNPNLIRTKSFAAAGLCAWVINI 1072
Cdd:COG5245 2223 LL---GFEAKI--WFGEQQSL-RRDDFIRIIGKYPDEiEFDLEARRFREARECSDPSFTGSILNRASKACGPLKRWLVRE 2296
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 1073 IRFYEVYCDVEPKRQALAQTNLDLAAATEKLEAVRRKLVDLDHNLSRLTASFEKATAEKVRCQEEVNQTNKTIDLANKLV 1152
Cdd:COG5245 2297 CNRSKVLEVKIPLREEEKRIDGEAFLVEDRLTLGKGLSSDLMTFKLRRRSYYSLDILRVHGKIADMDTVHKDVLRSIFVS 2376
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 1153 SELESEKIRWGQSIKSFETQEKTLCGDVLLTAAFVSYIGSFTRQYRQ-ELVDCKwiPFLQQKVSIP-------IAEGLDL 1224
Cdd:COG5245 2377 EILINEDSEWGGVFSEVPKLMVELDGDGHPSSCLHPYIGTLGFLCRAiEFGMSF--IRISKEFRDKeirrrqfITEGVQK 2454
|
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 1225 IamlTDDATIATWNNEGLPSDRMSTENATILthcerwPLMIDPQQQGIKWIKNKYGPdlKVTHLG---QKGFLNTIETAL 1301
Cdd:COG5245 2455 I---EDFKEEACSTDYGLENSRIRKDLQDLT------AVLNDPSSKIVTSQRQMYDE--KKAILGsfrEMEFAFGLSQAR 2523
|
1370 1380 1390 1400 1410 1420 1430 1440
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 1302 AFGDVILIENlKETVDPVLGPLLGRNTTKKGKFIR--IGDKECEFNKNFRLILHTKLANPHYKPELQAQTTLLNFTVTED 1379
Cdd:COG5245 2524 REGSDKIIGD-AEALDEEIGRLIKEEFKSNLSEVKvmINPPEIVRSTVEAVFWLSEGRSGDMGSIEWKQLIQVMFVSKVL 2602
|
1450 1460 1470 1480 1490 1500 1510 1520
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 1380 GLEGQLLAEVVSIERPDLERLKLVLTKQQNDFKIELRQLEDDLLLRLSAAEGSFLDDTDLVERLETTKATAAEIEHKVTE 1459
Cdd:COG5245 2603 GCETEIPDALEKLVSGPLFVHEKALNALKACGSLFLWVLARYLLAKLMLSISNMEQTDEIAVLLHNLKKSRKEIEEEESE 2682
|
1530 1540 1550 1560 1570 1580 1590 1600
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 1460 ARENERKINETRECYRPVAARASLLYFVISDLRRINPVYQFSLKAFNTLFHRaieqadkVEDTQERICALIESITHATFL 1539
Cdd:COG5245 2683 SMEIEDRIDALKSEYNASVKRLESIRVEIAMFDEKALMYNKSICELSSEFEK-------WRRMKSKYLCAIRYMLMSSEW 2755
|
1610 1620 1630 1640 1650 1660 1670 1680
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 1540 YasqaLFERDKLTFlsqmafqillrrneIHPLELDFLLRFTVEHTYSSPVDFLTAQSWSAVkavalmeeFRGLDRDVEGS 1619
Cdd:COG5245 2756 I----LDHEDRSGF--------------IHRLDVSFLLRTKRFVSTLLEDKNYRQVLSSCS--------LYGNDVISHSC 2809
|
1690 1700 1710 1720 1730 1740 1750 1760
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 1620 AKQWRKWVESEcpekeklpqewKKKSLIQKLIILRAVRPDRMTYALRNFVEEKLGAKYVERT--RLDLGKAFEESSPST- 1696
Cdd:COG5245 2810 DRFDRDVYRAL-----------KHQMDNRTHSTILTSNSKTNPYKEYTYNDSWAEAFEVEDSgdLYKFEEGLLELIVGHa 2878
|
1770 1780 1790 1800 1810 1820 1830 1840
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 1697 PVFFILSPGVDALKDLEVLG--KRLGFTIDSGKFHNVSlgqgqelvaemamekaaagGHWVILQNVHLVAKWlgtLEKLL 1774
Cdd:COG5245 2879 PLIYAHKKSLENERNVDRLGskENEVYAVLNSLFSRKE-------------------KSWFEVYNISLSFGW---FKRYV 2936
|
1850 1860 1870 1880 1890 1900 1910 1920
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 1775 EKFSQGS-----HRDYRVFLSAETVPSQhepiIPQGLLENSIKITNEPPTGMLANLhAALYNFDQ---DTLEMCSKDqef 1846
Cdd:COG5245 2937 EDVVYPIkasrvCGKVKNMWTSMVDADM----LPIQLLIAIDSFVSSTYPETGCGY-ADLVEIDRypfDYTLVIACD--- 3008
|
1930 1940 1950 1960 1970 1980 1990 2000
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 1847 ksILFSLCYFHACVAGRLRFGPQGWSRSYPFSPGDLTICTNILYNYLEANP--NVPWEDLRYLFGEIMYGGHITDAWD-- 1922
Cdd:COG5245 3009 --DAFYLSWEHAAVASVISAGPKENNEEIYFGDKDFEFKTHLLKNILFLNHlnARKWGNNRDLIFTIVYGKKHSLMEDsk 3086
|
2010
....*....|....*
gi 568978793 1923 --RKLCRVYLEEFMN 1935
Cdd:COG5245 3087 vvDKYCRGYGAHETS 3101
|
|
| AAA_7 |
pfam12775 |
P-loop containing dynein motor region; This domain is found in human cytoplasmic dynein-2 ... |
243-418 |
2.12e-87 |
|
P-loop containing dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities (AAA1-AAA6). This is the third nucleotide binding sites in the dynein motor. However, AAA3 has lost the catalytic residues necessary for ATP hydrolysis (the Walker B glutamate, the arginine finger, sensor-I and sensor-II motifs).
Pssm-ID: 463698 [Multi-domain] Cd Length: 179 Bit Score: 282.74 E-value: 2.12e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 243 DADAPLKTVLVHTPETTRLRYFTELLLCKGKPIMLVGNAGVGKTVFLSNTLASLS-ENYIVSCVPFNYYTTSAALQRILE 321
Cdd:pfam12775 2 PPDVPFSEILVPTVDTVRYTYLLDLLLKNGKPVLLVGPTGTGKTVIIQNLLRKLDkEKYLPLFINFSAQTTSNQTQDIIE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 322 KPLEKKAGRNYGPKGNKKLVYFIDDLNMPEVDLYGTIQPHALLRQHIDYGHWYDRHKIMLKEIRNCQYVACMNPMVGS-F 400
Cdd:pfam12775 82 SKLEKRRKGVYGPPGGKKLVVFIDDLNMPAVDTYGAQPPIELLRQWLDYGGWYDRKKLTFKEIVDVQFVAAMGPPGGGrN 161
|
170
....*....|....*...
gi 568978793 401 TVNPRLQRHFTVFAFNFP 418
Cdd:pfam12775 162 DITPRLLRHFNVFNITFP 179
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
844-968 |
1.84e-04 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 46.85 E-value: 1.84e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 844 LEQISLFKSLLKKKREEVKQKQEHLGNGIQKLQTTASQVGNLKSRLASQEAELQLRNLDAEALITKIGLQTEKVSREKAI 923
Cdd:COG1196 255 LEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEE 334
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 568978793 924 ADAEERKVAAIQTEASQKQRECEADLLKAEPALVAAKDALNTLNR 968
Cdd:COG1196 335 LEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEE 379
|
|
| Surf_Exclu_PgrA |
TIGR04320 |
SEC10/PgrA surface exclusion domain; This model describes a conserved domain found in surface ... |
873-967 |
5.67e-04 |
|
SEC10/PgrA surface exclusion domain; This model describes a conserved domain found in surface proteins of a number of Firmutes. Many members have LPXTG C-terminal anchoring motifs and a substantial number have the KxYKxGKxW putative sorting signal at the N-terminus. The tetracycline resistance plasmid pCF10 in Enterococcus faecalis promotes conjugal plasmid transfer in response to sex pheromones, but PgrA/Sec10 encoded by that plasmid, a member of this family, specifically inhibits the ability of cells to receive homologous plasmids. The phenomenon is called surface exclusion.
Pssm-ID: 275124 [Multi-domain] Cd Length: 356 Bit Score: 44.72 E-value: 5.67e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 873 QKLQTTASQVGNLKSRLASQEAEL-QLRNLDAEALITKIGLQTEKVSREKAIADAEErKVAAIQTEASQKQ----RECEA 947
Cdd:TIGR04320 247 TPIPNPPNSLAALQAKLATAQADLaAAQTALNTAQAALTSAQTAYAAAQAALATAQK-ELANAQAQALQTAqnnlATAQA 325
|
90 100
....*....|....*....|
gi 568978793 948 DLLKAEPALVAAKDALNTLN 967
Cdd:TIGR04320 326 ALANAEARLAKAKEALANLN 345
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| MT |
pfam12777 |
Microtubule-binding stalk of dynein motor; the 380 kDa motor unit of dynein belongs to the AAA ... |
866-1210 |
5.72e-172 |
|
Microtubule-binding stalk of dynein motor; the 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This family is the region between D4 and D5 and is the two predicted alpha-helical coiled coil segments that form the stalk supporting the ATP-sensitive microtubule binding component.
Pssm-ID: 463699 [Multi-domain] Cd Length: 344 Bit Score: 530.03 E-value: 5.72e-172
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 866 EHLGNGIQKLQTTASQVGNLKSRLASQEAELQLRNLDAEALITKIGLQTEKVSREKAIADAEERKVAAIQTEASQKQREC 945
Cdd:pfam12777 1 ERLENGLLKLHSTAAQVDDLKAKLAAQEAELKQKNEDADKLIQVVGIEADKVSKEKAIADEEEQKVAVIMKEVKEKQKAC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 946 EADLLKAEPALVAAKDALNTLNRVNLTELKTFPNPPNAVTNVTAAVMVLLAPRGRVPKDRSWKAAKIFMGKVDDFLQALI 1025
Cdd:pfam12777 81 EEDLAKAEPALLAAQAALDTLNKNNLTELKSFGSPPDAVSNVSAAVMILMAPGGKIPKDKSWKAAKIMMAKVDGFLDSLI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 1026 NYDKEHIPENCLKVVnEQYLKDPEFNPNLIRTKSFAAAGLCAWVINIIRFYEVYCDVEPKRQALAQTNLDLAAATEKLEA 1105
Cdd:pfam12777 161 KFDKEHIHEACLKAF-KPYLGDPEFDPEFIASKSTAAAGLCSWCINIVRFYEVFCDVAPKRQALEEANADLAAAQEKLAA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 1106 VRRKLVDLDHNLSRLTASFEKATAEKVRCQEEVNQTNKTIDLANKLVSELESEKIRWGQSIKSFETQEKTLCGDVLLTAA 1185
Cdd:pfam12777 240 IKAKIAELNANLAKLTAAFEKATADKIKCQQEADATARTILLANRLVGGLASENIRWADAVENFKQQERTLCGDILLISA 319
|
330 340
....*....|....*....|....*
gi 568978793 1186 FVSYIGSFTRQYRQELVDCKWIPFL 1210
Cdd:pfam12777 320 FISYLGFFTKKYRNELLDKFWIPYI 344
|
|
| Dynein_C |
pfam18199 |
Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein ... |
1988-2283 |
3.07e-123 |
|
Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein heavy chain. This domain is a complex structure comprising six alpha-helices and an incomplete six-stranded antiparallel beta-barrel. The shape of this domain is distinctively flat, spreading over the AAA1, AAA5 and AAA6 domain.
Pssm-ID: 465677 Cd Length: 301 Bit Score: 390.83 E-value: 3.07e-123
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 1988 TVTSNTLFRTLLEMQPRNAVSQEELGQSTEDKVKNILDDILERLPEEFNMAEIMQKNP--NRSPYVLVCFQECERMNVLI 2065
Cdd:pfam18199 1 TNETNELLSTLLSLQPRSDSGGGGGGSSREEIVLELAKDILEKLPEPFDIEEAEEKYPvgYEDPLNTVLLQEIERFNKLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 2066 REIRVSLQHLDLGLKGELTLSPDVETQLSALSYDRVPDTWNKLAYPSTYGLAQWFNDLLLRCRELDTWTQDLTLPAVVWL 2145
Cdd:pfam18199 81 KVIRRSLQDLQKAIKGLVVMSSELEELANSLLNGKVPESWAKKSYPSLKPLGSWIRDLLERLKQLQDWLDDEGPPKVFWL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 2146 SGFFNPQSFLTAIMQTMARKNEWPLDRMCLTIDVTKK-TKEDYGHPPREGAYLHGLHLEGARWDIQSGALVDARLKELTS 2224
Cdd:pfam18199 161 SGFFFPQAFLTAVLQNYARKNGWPIDKLSFDFEVTKKvSPEEVTEPPEDGVYVHGLFLEGARWDRKNGCLVESEPKELFS 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568978793 2225 MMPVIFAKAVPVDRQEIKHA-YECPVYKTKARG-PTYVWTFRLRSKDRIAKWVLAGVALLL 2283
Cdd:pfam18199 241 PLPVIHLKPVESDKKKLDENtYECPVYKTSERHsTNFVFSVDLPTDKPPDHWILRGVALLL 301
|
|
| AAA_9 |
pfam12781 |
ATP-binding dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. ... |
1235-1453 |
1.06e-111 |
|
ATP-binding dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities (AAA1-AAA6). This is the fifth AAA+ domain subdomain AAA5S. Structural analysis reveal that it is the coiled-coil buttress interface. The relative movement of AAA5S together with the stalk (AAA4S), is coupled to rearrangements in the AAA+ ring. Closure of the AAA1 site and the rigid body movement of AAA2-AAA4 force the AAA4/AAA5 interface to close and the AAA6L subdomain to rotate towards the ring centre. The AAA5S subdomain rotates as a unit together with AAA6L, and this movement pulls the buttress relative to the stalk.
Pssm-ID: 463702 [Multi-domain] Cd Length: 222 Bit Score: 354.44 E-value: 1.06e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 1235 ATWNNEGLPSDRMSTENATILTHCERWPLMIDPQQQGIKWIKNKYGP-DLKVTHLGQKGFLNTIETALAFGDVILIENLK 1313
Cdd:pfam12781 1 REWNIQGLPNDELSIENAIIVTNSRRWPLLIDPQGQANKWIKNMEKDnGLKVTSFTDKNFLKTLENAIRFGKPLLIEDVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 1314 ETVDPVLGPLLGRNTTKKG--KFIRIGDKECEFNKNFRLILHTKLANPHYKPELQAQTTLLNFTVTEDGLEGQLLAEVVS 1391
Cdd:pfam12781 81 EELDPILDPVLLKEIFKGGgrKVIKLGDKEVDYNPNFRLYLTTKLPNPHYPPEVAAKVTLINFTVTRSGLEDQLLGIVVK 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568978793 1392 IERPDLERLKLVLTKQQNDFKIELRQLEDDLLLRLSAAEGSFLDDTDLVERLETTKATAAEI 1453
Cdd:pfam12781 161 KERPDLEEQRNELIKEIAENKKQLKELEDKLLELLSSSEGNILDDEELIETLETSKKTSEEI 222
|
|
| AAA_8 |
pfam12780 |
P-loop containing dynein motor region D4; The 380 kDa motor unit of dynein belongs to the AAA ... |
594-853 |
4.59e-110 |
|
P-loop containing dynein motor region D4; The 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This particular family is the D4 ATP-binding region of the motor.
Pssm-ID: 463701 [Multi-domain] Cd Length: 259 Bit Score: 351.14 E-value: 4.59e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 594 MHLVLFEDAMQHVCRISRILRIPQGHALLIGVGGSGKQSLSRLAAYICSLEVFQITLTEGYGAQELRVDLANLYVRTGAK 673
Cdd:pfam12780 1 MDLVLFRDALEHLCRICRILRQPRGHALLVGVGGSGRQSLTKLAAFIAGYELFQIEVTRNYDMNEFREDLKKVLKKAGIK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 674 NMPTVFLLTDAHVLDESFLVLINDLLASGDIPDLFSDEDMDKIISGIRNEVRGLGLVDSRENCWAFFLARVRQQLKMVFC 753
Cdd:pfam12780 81 GKPTVFLLSDTQIIEESFLEDINNLLNSGEVPNLFTDEEKEEIIESVRDDAKAQNIEDSREAVYNYFVKRCRNNLHIVLC 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 754 FSPVGHTLRVRARKFPAIVNCTAIDWFHEWPQEALVSVSRRFIEEIEGIEpQHKDSISLFMAHVHTSVKEVSAWYYQNER 833
Cdd:pfam12780 161 MSPVGEAFRNRLRMFPSLVNCCTIDWFNEWPEEALLAVAEKFLEDIEIPE-ELKSNVVKVFVYVHSSVEDMSKKFYEELK 239
|
250 260
....*....|....*....|
gi 568978793 834 RYNYTTPRSFLEQISLFKSL 853
Cdd:pfam12780 240 RKNYVTPKSYLELLRLYKNL 259
|
|
| DYN1 |
COG5245 |
Dynein, heavy chain [Cytoskeleton]; |
5-1935 |
5.12e-97 |
|
Dynein, heavy chain [Cytoskeleton];
Pssm-ID: 227570 [Multi-domain] Cd Length: 3164 Bit Score: 351.98 E-value: 5.12e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 5 GLFSSILREQANLT-HDGPTWIVLDGdidplWIESLNTVMDDNKVLTLASNERvalkpsmRLLFEThhlRTATPATVSRA 83
Cdd:COG5245 1227 QFFLMFNREDMEARlADSKMEYEVER-----YVEKTKAEVSSLKLELSSVGEG-------QVVVSN---LGSIGDKVGRC 1291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 84 GILY----------VNPQDLG-WNPYVASWIDRRRHQSEKANLTILFDK-YIPVCLE---------KLRTSFKAITSVPE 142
Cdd:COG5245 1292 LVEYdsisrlstkgVFLDELGdTKRYLDECLDFFSCFEEVQKEIDELSMvFCADALRfsadlyhivKERRFSGVLAGSDA 1371
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 143 S-SLVQTICTLLECLLTPENIppDSPKETYEVYFAFACvwtFGGTLLRDQLSDYQ---ADFSrwwhKEMKAVKFPSQGTI 218
Cdd:COG5245 1372 SeSLGGKSIELAAILEHKDLI--VEMKRGINDVLKLRI---FGDKCRESTPRFYLisdGDLI----KDLNERSDYEEMLI 1442
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 219 FDYYLDHKTKKFLPwtdkVPQFSMDADAPL--KTVLVHTPETTRLRYFTELLLCKGKPIMLVGNAGVGKTVFLSNTLASl 296
Cdd:COG5245 1443 MMFNISAVITNNGS----IAGFELRGERVMlrKEVVIPTSDTGFVDSFSNEALNTLRSYIYCGPPGSGKEMLMCPSLRS- 1517
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 297 SENYIVSCVPFNYYTTSAALQRILEKPLEKKagRNYG-----PKGN-KKLVYFIDDLNMPEVDLYGTIQPHALLRQHIDY 370
Cdd:COG5245 1518 ELITEVKYFNFSTCTMTPSKLSVLERETEYY--PNTGvvrlyPKPVvKDLVLFCDEINLPYGFEYYPPTVIVFLRPLVER 1595
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 371 -GHWYDRHKiMLKEIRNCQYVACMNP--MVGSFTVNPRLQRHfTVFAF-NFPSLDALTTIYgqifSFYLQQQAFC-PSVL 445
Cdd:COG5245 1596 qGFWSSIAV-SWVTICGIILYGACNPgtDEGRVKYYERFIRK-PVFVFcCYPELASLRNIY----EAVLMGSYLCfDEFN 1669
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 446 RAGPSLIQATIAFHQMMAESFvPTAIKFHYNFNLRDLSNIFQGIL-FASPECLKSLEDLARLWLHETSRVYGDRLIDTND 524
Cdd:COG5245 1670 RLSEETMSASVELYLSSKDKT-KFFLQMNYGYKPRELTRSLRAIFgYAETRIDTPDVSLIIDWYCEAIREKIDRLVQQKE 1748
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 525 FDLFQRKMLETAHKYFKGVDANALLRQPLVYCHFASGGedpcyMPVKDWEGLKAVLMEMVDNYNELHSAMHLVLFEDAMQ 604
Cdd:COG5245 1749 SSTSRQDLYDFGLRAIREMIAGHIGEAEITFSMILFFG-----MACLLKKDLAVFVEEVRKIFGSSHLDVEAVAYKDALL 1823
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 605 HVCRISRILRIPQGHALLIGVGGSGKQSLSRLAAYICSLEVFQITLTEGYGAQELRVDLANLYVRTGAKNMPTVFLLTDA 684
Cdd:COG5245 1824 HILRSRRGLLVVGGHGVLKGVLIRGACDAREFVCWLNPRNMREIFGHRDELTGDFRDSLKVQDLRRNIHGGRECLFIFES 1903
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 685 HVLDESFLVLINDLLASGDIPDLFSDEDMDKIISGIRNEVRGLGL-VDSRENCWAFFLARVRQQLKMVFCFSPVGHTLRV 763
Cdd:COG5245 1904 IPVESSFLEDFNPLLDNNRFLCLFSGNERIRIPENLRFVFESTSLeKDTEATLTRVFLVYMEENLPVVFSACCSQDTSVL 1983
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 764 RARKFPAIVNCTAIDWFHEWPQEALVSVSRRFI-EEIEGIEPQH--------KDSISLFMAHVHTSVKEVSAWYYQNERR 834
Cdd:COG5245 1984 AGIRSPALKNRCFIDFKKLWDTEEMSQYANSVEtLSRDGGRVFFingelgvgKGALISEVFGDDAVVIEGRGFEISMIEG 2063
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 835 YNYTTPRSFLEQISLFKSLLKKKREEVKQKQEHLGNGIQKLQTTASQVGNLKSRLASQEAELQLRNLDAEALITKIgLQT 914
Cdd:COG5245 2064 SLGESKIKFIGGLKVYDARCVIYIEELDCTNVNLVEGVRKYNEYGRGMGELKEQLSNTVVILGVKEKNADDALSGT-PGE 2142
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 915 EKVSREKAIADAEERKVAAIQTEASQKQRECEADLLK-AEPALVAAKDALNTLNRVNLTELKTFPNPPNAVTNVTAAVMV 993
Cdd:COG5245 2143 RLEREVKSVFVEAPRDMLFLLEEEVRKRKGSVMKFKSsKKPAVLEAVLFVYKIKKASLREIRSFIRPPGDLCIEMEDVCD 2222
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 994 LLaprGRVPKDrsWKAAKIFMgKVDDFLQALINYDKE-HIPENCLKVVNEQYLKDPEFNPNLIRTKSFAAAGLCAWVINI 1072
Cdd:COG5245 2223 LL---GFEAKI--WFGEQQSL-RRDDFIRIIGKYPDEiEFDLEARRFREARECSDPSFTGSILNRASKACGPLKRWLVRE 2296
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 1073 IRFYEVYCDVEPKRQALAQTNLDLAAATEKLEAVRRKLVDLDHNLSRLTASFEKATAEKVRCQEEVNQTNKTIDLANKLV 1152
Cdd:COG5245 2297 CNRSKVLEVKIPLREEEKRIDGEAFLVEDRLTLGKGLSSDLMTFKLRRRSYYSLDILRVHGKIADMDTVHKDVLRSIFVS 2376
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 1153 SELESEKIRWGQSIKSFETQEKTLCGDVLLTAAFVSYIGSFTRQYRQ-ELVDCKwiPFLQQKVSIP-------IAEGLDL 1224
Cdd:COG5245 2377 EILINEDSEWGGVFSEVPKLMVELDGDGHPSSCLHPYIGTLGFLCRAiEFGMSF--IRISKEFRDKeirrrqfITEGVQK 2454
|
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 1225 IamlTDDATIATWNNEGLPSDRMSTENATILthcerwPLMIDPQQQGIKWIKNKYGPdlKVTHLG---QKGFLNTIETAL 1301
Cdd:COG5245 2455 I---EDFKEEACSTDYGLENSRIRKDLQDLT------AVLNDPSSKIVTSQRQMYDE--KKAILGsfrEMEFAFGLSQAR 2523
|
1370 1380 1390 1400 1410 1420 1430 1440
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 1302 AFGDVILIENlKETVDPVLGPLLGRNTTKKGKFIR--IGDKECEFNKNFRLILHTKLANPHYKPELQAQTTLLNFTVTED 1379
Cdd:COG5245 2524 REGSDKIIGD-AEALDEEIGRLIKEEFKSNLSEVKvmINPPEIVRSTVEAVFWLSEGRSGDMGSIEWKQLIQVMFVSKVL 2602
|
1450 1460 1470 1480 1490 1500 1510 1520
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 1380 GLEGQLLAEVVSIERPDLERLKLVLTKQQNDFKIELRQLEDDLLLRLSAAEGSFLDDTDLVERLETTKATAAEIEHKVTE 1459
Cdd:COG5245 2603 GCETEIPDALEKLVSGPLFVHEKALNALKACGSLFLWVLARYLLAKLMLSISNMEQTDEIAVLLHNLKKSRKEIEEEESE 2682
|
1530 1540 1550 1560 1570 1580 1590 1600
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 1460 ARENERKINETRECYRPVAARASLLYFVISDLRRINPVYQFSLKAFNTLFHRaieqadkVEDTQERICALIESITHATFL 1539
Cdd:COG5245 2683 SMEIEDRIDALKSEYNASVKRLESIRVEIAMFDEKALMYNKSICELSSEFEK-------WRRMKSKYLCAIRYMLMSSEW 2755
|
1610 1620 1630 1640 1650 1660 1670 1680
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 1540 YasqaLFERDKLTFlsqmafqillrrneIHPLELDFLLRFTVEHTYSSPVDFLTAQSWSAVkavalmeeFRGLDRDVEGS 1619
Cdd:COG5245 2756 I----LDHEDRSGF--------------IHRLDVSFLLRTKRFVSTLLEDKNYRQVLSSCS--------LYGNDVISHSC 2809
|
1690 1700 1710 1720 1730 1740 1750 1760
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 1620 AKQWRKWVESEcpekeklpqewKKKSLIQKLIILRAVRPDRMTYALRNFVEEKLGAKYVERT--RLDLGKAFEESSPST- 1696
Cdd:COG5245 2810 DRFDRDVYRAL-----------KHQMDNRTHSTILTSNSKTNPYKEYTYNDSWAEAFEVEDSgdLYKFEEGLLELIVGHa 2878
|
1770 1780 1790 1800 1810 1820 1830 1840
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 1697 PVFFILSPGVDALKDLEVLG--KRLGFTIDSGKFHNVSlgqgqelvaemamekaaagGHWVILQNVHLVAKWlgtLEKLL 1774
Cdd:COG5245 2879 PLIYAHKKSLENERNVDRLGskENEVYAVLNSLFSRKE-------------------KSWFEVYNISLSFGW---FKRYV 2936
|
1850 1860 1870 1880 1890 1900 1910 1920
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 1775 EKFSQGS-----HRDYRVFLSAETVPSQhepiIPQGLLENSIKITNEPPTGMLANLhAALYNFDQ---DTLEMCSKDqef 1846
Cdd:COG5245 2937 EDVVYPIkasrvCGKVKNMWTSMVDADM----LPIQLLIAIDSFVSSTYPETGCGY-ADLVEIDRypfDYTLVIACD--- 3008
|
1930 1940 1950 1960 1970 1980 1990 2000
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 1847 ksILFSLCYFHACVAGRLRFGPQGWSRSYPFSPGDLTICTNILYNYLEANP--NVPWEDLRYLFGEIMYGGHITDAWD-- 1922
Cdd:COG5245 3009 --DAFYLSWEHAAVASVISAGPKENNEEIYFGDKDFEFKTHLLKNILFLNHlnARKWGNNRDLIFTIVYGKKHSLMEDsk 3086
|
2010
....*....|....*
gi 568978793 1923 --RKLCRVYLEEFMN 1935
Cdd:COG5245 3087 vvDKYCRGYGAHETS 3101
|
|
| AAA_7 |
pfam12775 |
P-loop containing dynein motor region; This domain is found in human cytoplasmic dynein-2 ... |
243-418 |
2.12e-87 |
|
P-loop containing dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities (AAA1-AAA6). This is the third nucleotide binding sites in the dynein motor. However, AAA3 has lost the catalytic residues necessary for ATP hydrolysis (the Walker B glutamate, the arginine finger, sensor-I and sensor-II motifs).
Pssm-ID: 463698 [Multi-domain] Cd Length: 179 Bit Score: 282.74 E-value: 2.12e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 243 DADAPLKTVLVHTPETTRLRYFTELLLCKGKPIMLVGNAGVGKTVFLSNTLASLS-ENYIVSCVPFNYYTTSAALQRILE 321
Cdd:pfam12775 2 PPDVPFSEILVPTVDTVRYTYLLDLLLKNGKPVLLVGPTGTGKTVIIQNLLRKLDkEKYLPLFINFSAQTTSNQTQDIIE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 322 KPLEKKAGRNYGPKGNKKLVYFIDDLNMPEVDLYGTIQPHALLRQHIDYGHWYDRHKIMLKEIRNCQYVACMNPMVGS-F 400
Cdd:pfam12775 82 SKLEKRRKGVYGPPGGKKLVVFIDDLNMPAVDTYGAQPPIELLRQWLDYGGWYDRKKLTFKEIVDVQFVAAMGPPGGGrN 161
|
170
....*....|....*...
gi 568978793 401 TVNPRLQRHFTVFAFNFP 418
Cdd:pfam12775 162 DITPRLLRHFNVFNITFP 179
|
|
| AAA_lid_11 |
pfam18198 |
Dynein heavy chain AAA lid domain; This family represents the AAA lid domain found neat the ... |
1846-1982 |
7.24e-65 |
|
Dynein heavy chain AAA lid domain; This family represents the AAA lid domain found neat the C-terminal region of dynein heavy chain.
Pssm-ID: 465676 Cd Length: 139 Bit Score: 216.55 E-value: 7.24e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 1846 FKSILFSLCYFHACVAGRLRFGPQGWSRSYPFSPGDLTICTNILYNYLEANP-NVPWEDLRYLFGEIMYGGHITDAWDRK 1924
Cdd:pfam18198 1 WKKLLFGLCFFHAVVQERRKFGPLGWNIPYEFNESDLRISVQQLQMYLDEYDeKIPWDALRYLIGEINYGGRVTDDWDRR 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 1925 LCRVYLEEFMNPSLIEDEVMLAPG-FAAPPYSDYSGYHQYIEdTLP-PESPALYGLHPNA 1982
Cdd:pfam18198 81 LLNTYLEEFFNPEVLEEDFKFSPSlYYIPPDGDLEDYLEYIE-SLPlVDSPEVFGLHPNA 139
|
|
| Dynein_heavy |
pfam03028 |
Dynein heavy chain region D6 P-loop domain; This family represents the C-terminal region of ... |
1693-1814 |
1.14e-42 |
|
Dynein heavy chain region D6 P-loop domain; This family represents the C-terminal region of dynein heavy chain. The chain also contains ATPase activity and microtubule binding ability and acts as a motor for the movement of organelles and vesicles along microtubules. Dynein is also involved in cilia and flagella movement. The dynein subunit consists of at least two heavy chains and a number of intermediate and light chains. The 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This C-terminal domain carries the D6 region of the dynein motor where the P-loop has been lost in evolution but the general structure of a potential ATP binding site appears to be retained.
Pssm-ID: 460782 Cd Length: 115 Bit Score: 152.21 E-value: 1.14e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 1693 SPSTPVFFILSPGVDALKDLEVLGKRLGFTidsGKFHNVSLGQGQELVAEMAMEKAAAGGHWVILQNVHLVAKWLGTLEK 1772
Cdd:pfam03028 1 SPTTPLIFILSPGSDPTADLEKLAKKLGFG---GKLHSISLGQGQGPIAEKLIEEAAKEGGWVLLQNCHLALSWMPELEK 77
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 568978793 1773 LLEKF-SQGSHRDYRVFLSAEtvPSqhePIIPQGLLENSIKIT 1814
Cdd:pfam03028 78 ILEELpEETLHPDFRLWLTSE--PS---PKFPISILQNSIKIT 115
|
|
| AAA_lid_1 |
pfam17857 |
AAA+ lid domain; This domain represents the AAA lid domain from dynein heavy chain D3. |
451-540 |
5.08e-36 |
|
AAA+ lid domain; This domain represents the AAA lid domain from dynein heavy chain D3.
Pssm-ID: 465535 [Multi-domain] Cd Length: 100 Bit Score: 132.75 E-value: 5.08e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 451 LIQATIAFHQMMAESFVPTAIKFHYNFNLRDLSNIFQGILFASPECLKSLEDLARLWLHETSRVYGDRLIDTNDFDLFQR 530
Cdd:pfam17857 1 LIAAALAFHQKIAATFLPTAIKFHYIFNLRDFANIFQGILFSSAECLKSPLDLIRLWLHESERVYGDKMVDEKDFDLFDK 80
|
90
....*....|
gi 568978793 531 KMLETAHKYF 540
Cdd:pfam17857 81 IQMASLKKFF 90
|
|
| Dynein_AAA_lid |
pfam17852 |
Dynein heavy chain AAA lid domain; This entry corresponds to the extension domain of AAA ... |
118-235 |
1.15e-29 |
|
Dynein heavy chain AAA lid domain; This entry corresponds to the extension domain of AAA domain 5 in the dynein heavy chain. This domain is composed of 8 alpha helices.
Pssm-ID: 465532 [Multi-domain] Cd Length: 126 Bit Score: 115.46 E-value: 1.15e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 118 LFDKYIPVCLEKLRTSFKAITSVPESSLVQTICTLLECLLTP-------ENIPPDSPKETYEVYFAFACVWTFGGTLLRD 190
Cdd:pfam17852 4 LFEWLVPPALEFVRKNCKEIVPTSDLNLVQSLCRLLESLLDEvleyngvHPLSPDKLKEYLEKLFLFALVWSIGGTLDED 83
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 568978793 191 QlsdyQADFSRWWHKEMKAVKFP--SQGTIFDYYLDHKTKKFLPWTD 235
Cdd:pfam17852 84 S----RKKFDEFLRELFSGLDLPppEKGTVYDYFVDLEKGEWVPWSD 126
|
|
| AAA_5 |
pfam07728 |
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ... |
274-410 |
6.37e-07 |
|
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.
Pssm-ID: 400191 [Multi-domain] Cd Length: 135 Bit Score: 50.75 E-value: 6.37e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 274 PIMLVGNAGVGKTvFLSNTLASLSENYIVSCVPFNYYTTSAALQRILEkPLEKKAGRNYGP---KGNKKLVYFIDDLNMP 350
Cdd:pfam07728 1 GVLLVGPPGTGKT-ELAERLAAALSNRPVFYVQLTRDTTEEDLFGRRN-IDPGGASWVDGPlvrAAREGEIAVLDEINRA 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568978793 351 EVDLYGTIQPhaLL---RQHIDYGHWYDRHKimlKEIRNCqyVACMNP-MVGSFTVNPRLQRHF 410
Cdd:pfam07728 79 NPDVLNSLLS--LLderRLLLPDGGELVKAA---PDGFRL--IATMNPlDRGLNELSPALRSRF 135
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
844-968 |
1.84e-04 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 46.85 E-value: 1.84e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 844 LEQISLFKSLLKKKREEVKQKQEHLGNGIQKLQTTASQVGNLKSRLASQEAELQLRNLDAEALITKIGLQTEKVSREKAI 923
Cdd:COG1196 255 LEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEE 334
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 568978793 924 ADAEERKVAAIQTEASQKQRECEADLLKAEPALVAAKDALNTLNR 968
Cdd:COG1196 335 LEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEE 379
|
|
| DUF4515 |
pfam14988 |
Domain of unknown function (DUF4515); This family of proteins is found in bacteria and ... |
846-976 |
3.54e-04 |
|
Domain of unknown function (DUF4515); This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 198 and 469 amino acids in length. There are two completely conserved L residues that may be functionally important.
Pssm-ID: 405647 [Multi-domain] Cd Length: 206 Bit Score: 43.99 E-value: 3.54e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 846 QISLFKSLLKKKREEVKQKQEHLGNG-IQKLQTTASQVGNLKSRLASQEAELQLRNLDAEALITKIGLQTE--------K 916
Cdd:pfam14988 1 ENKFFLEYLAKKTEEKQKKIEKLWNQyVQECEEIERRRQELASRYTQQTAELQTQLLQKEKEQASLKKELQalrpfaklK 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 917 VSREKAIADAEERKvAAIQTEASQKQRECEADLLKAEPALvaaKDALNTLNRVNLTELKT 976
Cdd:pfam14988 81 ESQEREIQDLEEEK-EKVRAETAEKDREAHLQFLKEKALL---EKQLQELRILELGERAT 136
|
|
| Laminin_II |
pfam06009 |
Laminin Domain II; It has been suggested that the domains I and II from laminin A, B1 and B2 ... |
1092-1156 |
4.20e-04 |
|
Laminin Domain II; It has been suggested that the domains I and II from laminin A, B1 and B2 may come together to form a triple helical coiled-coil structure.
Pssm-ID: 368703 [Multi-domain] Cd Length: 138 Bit Score: 42.47 E-value: 4.20e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568978793 1092 TNLDLAAATEKLEAVRRKLVDLDHNLSRLTASFEKATAEKVRCQEEVNQTNKTIDLANKLVSELE 1156
Cdd:pfam06009 1 SKELAREANETAKEVLEQLAPLSQNLENTSEKLSGINRSLEETNELVNDANKALDDAGRSVKKLE 65
|
|
| Surf_Exclu_PgrA |
TIGR04320 |
SEC10/PgrA surface exclusion domain; This model describes a conserved domain found in surface ... |
873-967 |
5.67e-04 |
|
SEC10/PgrA surface exclusion domain; This model describes a conserved domain found in surface proteins of a number of Firmutes. Many members have LPXTG C-terminal anchoring motifs and a substantial number have the KxYKxGKxW putative sorting signal at the N-terminus. The tetracycline resistance plasmid pCF10 in Enterococcus faecalis promotes conjugal plasmid transfer in response to sex pheromones, but PgrA/Sec10 encoded by that plasmid, a member of this family, specifically inhibits the ability of cells to receive homologous plasmids. The phenomenon is called surface exclusion.
Pssm-ID: 275124 [Multi-domain] Cd Length: 356 Bit Score: 44.72 E-value: 5.67e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 873 QKLQTTASQVGNLKSRLASQEAEL-QLRNLDAEALITKIGLQTEKVSREKAIADAEErKVAAIQTEASQKQ----RECEA 947
Cdd:TIGR04320 247 TPIPNPPNSLAALQAKLATAQADLaAAQTALNTAQAALTSAQTAYAAAQAALATAQK-ELANAQAQALQTAqnnlATAQA 325
|
90 100
....*....|....*....|
gi 568978793 948 DLLKAEPALVAAKDALNTLN 967
Cdd:TIGR04320 326 ALANAEARLAKAKEALANLN 345
|
|
| COG4372 |
COG4372 |
Uncharacterized protein, contains DUF3084 domain [Function unknown]; |
841-975 |
2.70e-03 |
|
Uncharacterized protein, contains DUF3084 domain [Function unknown];
Pssm-ID: 443500 [Multi-domain] Cd Length: 370 Bit Score: 42.58 E-value: 2.70e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 841 RSFLEQISLFKSLLKKKREEVKQKQEHLGNGIQKLQTTasqvgnlKSRLASQEAELQLRNLDAEALITKIGLQTEKVSRE 920
Cdd:COG4372 34 RKALFELDKLQEELEQLREELEQAREELEQLEEELEQA-------RSELEQLEEELEELNEQLQAAQAELAQAQEELESL 106
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 568978793 921 KAIADAEERKVAAIQTE---ASQKQRECEADLLKAEPALVAAKDALNTLNRvNLTELK 975
Cdd:COG4372 107 QEEAEELQEELEELQKErqdLEQQRKQLEAQIAELQSEIAEREEELKELEE-QLESLQ 163
|
|
| COG4372 |
COG4372 |
Uncharacterized protein, contains DUF3084 domain [Function unknown]; |
1086-1176 |
4.69e-03 |
|
Uncharacterized protein, contains DUF3084 domain [Function unknown];
Pssm-ID: 443500 [Multi-domain] Cd Length: 370 Bit Score: 41.81 E-value: 4.69e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 1086 RQALAQTNLDLAAATEKLEAVRRKLVDLDHNLSRLTASFEKATAEKVRCQEEVNQTNKTIDLANKLVSELESEKIRWGQS 1165
Cdd:COG4372 51 REELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEEAEELQEELEELQKERQDLEQQ 130
|
90
....*....|.
gi 568978793 1166 IKSFETQEKTL 1176
Cdd:COG4372 131 RKQLEAQIAEL 141
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
845-975 |
5.93e-03 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 41.85 E-value: 5.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 845 EQISLFKSLLKKKREEVKQKQEHLGNGIQKLQTTASQVGNLKSRLASQEAELQLRNLDAEALITKIGLQTEKVSREKAIA 924
Cdd:COG1196 267 AELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEEL 346
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 568978793 925 DAEERKVAAIQTEASQKQREceadLLKAEPALVAAKDALNTLNRVNLTELK 975
Cdd:COG1196 347 EEAEEELEEAEAELAEAEEA----LLEAEAELAEAEEELEELAEELLEALR 393
|
|
| COG4372 |
COG4372 |
Uncharacterized protein, contains DUF3084 domain [Function unknown]; |
1086-1176 |
6.03e-03 |
|
Uncharacterized protein, contains DUF3084 domain [Function unknown];
Pssm-ID: 443500 [Multi-domain] Cd Length: 370 Bit Score: 41.43 E-value: 6.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568978793 1086 RQALAQTNLDLAAATEKLEAVRRKLVDLDHNLSRLTASFEKATAEKVRCQEEVNQTNKTIDLANKLVSELESEKIRWGQS 1165
Cdd:COG4372 79 EEELEELNEQLQAAQAELAQAQEELESLQEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQ 158
|
90
....*....|.
gi 568978793 1166 IKSFETQEKTL 1176
Cdd:COG4372 159 LESLQEELAAL 169
|
|
| |
