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Conserved domains on  [gi|568968419|ref|XP_006514120|]
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nucleoporin Nup37 isoform X1 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
16-216 2.79e-18

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 83.42  E-value: 2.79e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968419  16 EDYVHVVEFNPfesgdSGNLIAYGGSNYVVV------GmctfqeeetdiegiqyKTLRTF-HHGVRVDGIAWSPETKLds 88
Cdd:COG2319  162 SGAVTSVAFSP-----DGKLLASGSDDGTVRlwdlatG----------------KLLRTLtGHTGAVRSVAFSPDGKL-- 218

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968419  89 lppvikFCTSAADLKIRLFtsDLQDKNEYKVLEGHSDFINDLVFHPKeGQELASVSDDHTCRIWNLEGKQTAHFLLHSPG 168
Cdd:COG2319  219 ------LASGSADGTVRLW--DLATGKLLRTLTGHSGSVRSVAFSPD-GRLLASGSADGTVRLWDLATGELLRTLTGHSG 289

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 568968419 169 --MSVCWHPEETFkLMVAEKNGTIRFYDLMAQQAILSLQSEQTPLMSAHW 216
Cdd:COG2319  290 gvNSVAFSPDGKL-LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAF 338
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
16-216 2.79e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 83.42  E-value: 2.79e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968419  16 EDYVHVVEFNPfesgdSGNLIAYGGSNYVVV------GmctfqeeetdiegiqyKTLRTF-HHGVRVDGIAWSPETKLds 88
Cdd:COG2319  162 SGAVTSVAFSP-----DGKLLASGSDDGTVRlwdlatG----------------KLLRTLtGHTGAVRSVAFSPDGKL-- 218

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968419  89 lppvikFCTSAADLKIRLFtsDLQDKNEYKVLEGHSDFINDLVFHPKeGQELASVSDDHTCRIWNLEGKQTAHFLLHSPG 168
Cdd:COG2319  219 ------LASGSADGTVRLW--DLATGKLLRTLTGHSGSVRSVAFSPD-GRLLASGSADGTVRLWDLATGELLRTLTGHSG 289

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 568968419 169 --MSVCWHPEETFkLMVAEKNGTIRFYDLMAQQAILSLQSEQTPLMSAHW 216
Cdd:COG2319  290 gvNSVAFSPDGKL-LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAF 338
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 64-237 3.82e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 81.61  E-value: 3.82e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968419  64 KTLRTFH-HGVRVDGIAWSPETKLdslppvikFCTSAADLKIRLFtsDLQDKNEYKVLEGHSDFINDLVFHPkEGQELAS 142
Cdd:cd00200   84 ECVRTLTgHTSYVSSVAFSPDGRI--------LSSSSRDKTIKVW--DVETGKCLTTLRGHTDWVNSVAFSP-DGTFVAS 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968419 143 VSDDHTCRIWNLEGKQTAHFLLH--SPGMSVCWHPEEtFKLMVAEKNGTIRFYDLMAQQAILSLQSEQTPLMSAHWCLKN 220
Cdd:cd00200  153 SSQDGTIKLWDLRTGKCVATLTGhtGEVNSVAFSPDG-EKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDG 231

                        170
                 ....*....|....*..
gi 568968419 221 TFKVGAVAGNDWIIWDI 237
Cdd:cd00200  232 YLLASGSEDGTIRVWDL 248
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 113-153 9.74e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 9.74e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 568968419   113 DKNEYKVLEGHSDFINDLVFHPkEGQELASVSDDHTCRIWN 153
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
118-153 3.28e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.10  E-value: 3.28e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568968419  118 KVLEGHSDFINDLVFHPkEGQELASVSDDHTCRIWN 153
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
16-216 2.79e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 83.42  E-value: 2.79e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968419  16 EDYVHVVEFNPfesgdSGNLIAYGGSNYVVV------GmctfqeeetdiegiqyKTLRTF-HHGVRVDGIAWSPETKLds 88
Cdd:COG2319  162 SGAVTSVAFSP-----DGKLLASGSDDGTVRlwdlatG----------------KLLRTLtGHTGAVRSVAFSPDGKL-- 218

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968419  89 lppvikFCTSAADLKIRLFtsDLQDKNEYKVLEGHSDFINDLVFHPKeGQELASVSDDHTCRIWNLEGKQTAHFLLHSPG 168
Cdd:COG2319  219 ------LASGSADGTVRLW--DLATGKLLRTLTGHSGSVRSVAFSPD-GRLLASGSADGTVRLWDLATGELLRTLTGHSG 289

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 568968419 169 --MSVCWHPEETFkLMVAEKNGTIRFYDLMAQQAILSLQSEQTPLMSAHW 216
Cdd:COG2319  290 gvNSVAFSPDGKL-LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAF 338
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 64-237 3.82e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 81.61  E-value: 3.82e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968419  64 KTLRTFH-HGVRVDGIAWSPETKLdslppvikFCTSAADLKIRLFtsDLQDKNEYKVLEGHSDFINDLVFHPkEGQELAS 142
Cdd:cd00200   84 ECVRTLTgHTSYVSSVAFSPDGRI--------LSSSSRDKTIKVW--DVETGKCLTTLRGHTDWVNSVAFSP-DGTFVAS 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968419 143 VSDDHTCRIWNLEGKQTAHFLLH--SPGMSVCWHPEEtFKLMVAEKNGTIRFYDLMAQQAILSLQSEQTPLMSAHWCLKN 220
Cdd:cd00200  153 SSQDGTIKLWDLRTGKCVATLTGhtGEVNSVAFSPDG-EKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDG 231

                        170
                 ....*....|....*..
gi 568968419 221 TFKVGAVAGNDWIIWDI 237
Cdd:cd00200  232 YLLASGSEDGTIRVWDL 248
WD40 COG2319
WD40 repeat [General function prediction only];
64-216 7.98e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 79.18  E-value: 7.98e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968419  64 KTLRTF-HHGVRVDGIAWSPETKLdslppVIkfcTSAADLKIRLFtsDLQDKNEYKVLEGHSDFINDLVFHPkEGQELAS 142
Cdd:COG2319  153 KLLRTLtGHSGAVTSVAFSPDGKL-----LA---SGSDDGTVRLW--DLATGKLLRTLTGHTGAVRSVAFSP-DGKLLAS 221

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568968419 143 VSDDHTCRIWNLEGKQTAHFLLHSPGM--SVCWHPEETFkLMVAEKNGTIRFYDLMAQQAILSLQSEQTPLMSAHW 216
Cdd:COG2319  222 GSADGTVRLWDLATGKLLRTLTGHSGSvrSVAFSPDGRL-LASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAF 296
WD40 COG2319
WD40 repeat [General function prediction only];
64-195 2.93e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 77.64  E-value: 2.93e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968419  64 KTLRTF-HHGVRVDGIAWSPETKLdslppvikFCTSAADLKIRLFtsDLQDKNEYKVLEGHSDFINDLVFHPKeGQELAS 142
Cdd:COG2319  279 ELLRTLtGHSGGVNSVAFSPDGKL--------LASGSDDGTVRLW--DLATGKLLRTLTGHTGAVRSVAFSPD-GKTLAS 347

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 568968419 143 VSDDHTCRIWNLEGKQTAHFLL-HSPG-MSVCWHPEETFkLMVAEKNGTIRFYDL 195
Cdd:COG2319  348 GSDDGTVRLWDLATGELLRTLTgHTGAvTSVAFSPDGRT-LASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 71-250 3.79e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 73.52  E-value: 3.79e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968419  71 HGVRVDGIAWSPETKLdslppvikFCTSAADLKIRLFtsDLQDKNEYKVLEGHSDFINDLVFHPKeGQELASVSDDHTCR 150
Cdd:cd00200    8 HTGGVTCVAFSPDGKL--------LATGSGDGTIKVW--DLETGELLRTLKGHTGPVRDVAASAD-GTYLASGSSDKTIR 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968419 151 IWNLEGKQTAH-FLLH-SPGMSVCWHPEETFkLMVAEKNGTIRFYDLMAQQAILSLQSEQTPLMSAHWCLKNTFKVGAVA 228
Cdd:cd00200   77 LWDLETGECVRtLTGHtSYVSSVAFSPDGRI-LSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQ 155

                        170       180
                 ....*....|....*....|..
gi 568968419 229 GNDWIIWDItRSSYPQETRPVH 250
Cdd:cd00200  156 DGTIKLWDL-RTGKCVATLTGH 176
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 59-216 5.84e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 72.75  E-value: 5.84e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968419  59 EGIQYKTLRTFH-HGVRVDGIAWSPETKLDSlppvikfcTSAADLKIRLFtsDLQDKNEYKVLEGHSDFINDLVFHPKeG 137
Cdd:cd00200  121 DVETGKCLTTLRgHTDWVNSVAFSPDGTFVA--------SSSQDGTIKLW--DLRTGKCVATLTGHTGEVNSVAFSPD-G 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968419 138 QELASVSDDHTCRIWNL-EGKQTAHFLLHSPG-MSVCWHPEETFkLMVAEKNGTIRFYDLMAQQAILSLQSEQTPLMSAH 215
Cdd:cd00200  190 EKLLSSSSDGTIKLWDLsTGKCLGTLRGHENGvNSVAFSPDGYL-LASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLA 268


                 .
gi 568968419 216 W 216
Cdd:cd00200  269 W 269
WD40 COG2319
WD40 repeat [General function prediction only];
71-259 1.90e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 72.25  E-value: 1.90e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968419  71 HGVRVDGIAWSPETKLDSlppvikfcTSAADLKIRLFtsDLQDKNEYKVLEGHSDFINDLVFHPkEGQELASVSDDHTCR 150
Cdd:COG2319   77 HTAAVLSVAFSPDGRLLA--------SASADGTVRLW--DLATGLLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVR 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968419 151 IWNLE-GKQTAHFLLHSPGM-SVCWHPEETFkLMVAEKNGTIRFYDLMAQQAILSLQSEQTPLMSAHWCLKNTFKVGAVA 228
Cdd:COG2319  146 LWDLAtGKLLRTLTGHSGAVtSVAFSPDGKL-LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSA 224

                        170       180       190
                 ....*....|....*....|....*....|...
gi 568968419 229 GNDWIIWDITRSSyPQETRPVHMDRAH--LFSP 259
Cdd:COG2319  225 DGTVRLWDLATGK-LLRTLTGHSGSVRsvAFSP 256
WD40 COG2319
WD40 repeat [General function prediction only];
64-156 3.71e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 65.70  E-value: 3.71e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968419  64 KTLRTF-HHGVRVDGIAWSPETKLdslppvikFCTSAADLKIRLFtsDLQDKNEYKVLEGHSDFINDLVFHPkEGQELAS 142
Cdd:COG2319  321 KLLRTLtGHTGAVRSVAFSPDGKT--------LASGSDDGTVRLW--DLATGELLRTLTGHTGAVTSVAFSP-DGRTLAS 389

                         90
                 ....*....|....
gi 568968419 143 VSDDHTCRIWNLEG 156
Cdd:COG2319  390 GSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 59-153 1.89e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 56.96  E-value: 1.89e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968419  59 EGIQYKTLRTfhHGVRVDGIAWSPETKLdslppvikFCTSAADLKIRLFtsDLQDKNEYKVLEGHSDFINDLVFHPkEGQ 138
Cdd:cd00200  208 TGKCLGTLRG--HENGVNSVAFSPDGYL--------LASGSEDGTIRVW--DLRTGECVQTLSGHTNSVTSLAWSP-DGK 274

                         90
                 ....*....|....*
gi 568968419 139 ELASVSDDHTCRIWN 153
Cdd:cd00200  275 RLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 116-264 1.81e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 53.88  E-value: 1.81e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968419 116 EYKVLEGHSDFINDLVFHPkEGQELASVSDDHTCRIWNLEGKQTAHFL-LHSPGMSVC-WHPEETFkLMVAEKNGTIRFY 193
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLETGELLRTLkGHTGPVRDVaASADGTY-LASGSSDKTIRLW 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568968419 194 DLMAQQAILSLQSEQTPLMSAHWCLKNTFKVGAVAGNDWIIWDItRSSYPQETRPVHMDRAH--LFSPSSLVL 264
Cdd:cd00200   79 DLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV-ETGKCLTTLRGHTDWVNsvAFSPDGTFV 150
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 113-153 9.74e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 9.74e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 568968419   113 DKNEYKVLEGHSDFINDLVFHPkEGQELASVSDDHTCRIWN 153
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
118-153 3.28e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.10  E-value: 3.28e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568968419  118 KVLEGHSDFINDLVFHPkEGQELASVSDDHTCRIWN 153
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 170-217 3.29e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 36.10  E-value: 3.29e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 568968419  170 SVCWHPEETFkLMVAEKNGTIRFYDLMAQQAILSLQSEQTPLMSAHWC 217
Cdd:pfam12894  43 SLAWRPDGKL-LAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWG 89
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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