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Conserved domains on  [gi|568967343|ref|XP_006513606|]
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tetraspanin-8 isoform X2 [Mus musculus]

Protein Classification

tetraspanin-8( domain architecture ID 13626496)

tetraspanin-8 is a transmembrane (TM) protein with four TM segments that acts as a molecular facilitator in diverse processes such as tissue differentiation, tumor-cell metastasis, and cell motility and cell fusion

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TM4SF3_like_LEL cd03154
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF3_like subfamily. ...
 40-138 1.04e-34

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF3_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contaions transmembrane 4 superfamily 3 (TM4SF3) or D6.1a and related proteins. D6.1a associates with alpha6beta4 integrin and supports cell motility, it has been ascribed a role in tumor progression and metastasis.


:

Pssm-ID: 239407 [Multi-domain]  Cd Length: 100  Bit Score: 117.14  E-value: 1.04e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967343  40 GAAFKPEYNRILNETLYENAKLLSDNTDEAKDFQKAMIVFQSEFKCCGLENGAADWGNNFveaKESCQCTGTDCAT---- 115
Cdd:cd03154    1 GIVGAVYKPKIENELKEKNTKLLSLLGQNAKSVKKSLEKFQKELKCCGLVNGADDWGNDI---PASCNCTTTQSDCvvay 77

                         90       100
                 ....*....|....*....|...
gi 568967343 116 YQGSSVYPKTCLSLIKDLFEKNI 138
Cdd:cd03154   78 YGGSNVYKEPCISKIKDFLKKNL 100
Tetraspanin pfam00335
Tetraspanin family;
1-164 1.49e-15

Tetraspanin family;


:

Pssm-ID: 459767  Cd Length: 183  Bit Score: 70.43  E-value: 1.49e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967343    1 MVLGFLGCCGAVKESRCMLLLFFIGLLLILILQVAAGILGAAFKPEYNRILNETLYENAKL-LSDNTDEAKDFQKAMIVF 79
Cdd:pfam00335  56 FLVGFLGCCGALKENRCLLLTYFVLLLLLFLAELAAGILAFVYRDKLSGLLSNWLKKSLEDgYRDWLDLYSCLNSALDSL 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967343   80 QSEFKCCGlengaadwgnnfveakescqctgtdcatyqgssvypkTCLSLIKDLFEKNIIIVIGIAFGLAVIEILGLVFS 159
Cdd:pfam00335 136 QSEFGCCG-------------------------------------GCKEKLLEWLRKNLKIIGAGVIALGVIQLLGIILA 178


                  ....*
gi 568967343  160 MVLYC 164
Cdd:pfam00335 179 CCLCC 183
 
Name Accession Description Interval E-value
TM4SF3_like_LEL cd03154
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF3_like subfamily. ...
 40-138 1.04e-34

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF3_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contaions transmembrane 4 superfamily 3 (TM4SF3) or D6.1a and related proteins. D6.1a associates with alpha6beta4 integrin and supports cell motility, it has been ascribed a role in tumor progression and metastasis.


Pssm-ID: 239407 [Multi-domain]  Cd Length: 100  Bit Score: 117.14  E-value: 1.04e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967343  40 GAAFKPEYNRILNETLYENAKLLSDNTDEAKDFQKAMIVFQSEFKCCGLENGAADWGNNFveaKESCQCTGTDCAT---- 115
Cdd:cd03154    1 GIVGAVYKPKIENELKEKNTKLLSLLGQNAKSVKKSLEKFQKELKCCGLVNGADDWGNDI---PASCNCTTTQSDCvvay 77

                         90       100
                 ....*....|....*....|...
gi 568967343 116 YQGSSVYPKTCLSLIKDLFEKNI 138
Cdd:cd03154   78 YGGSNVYKEPCISKIKDFLKKNL 100
Tetraspanin pfam00335
Tetraspanin family;
1-164 1.49e-15

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 70.43  E-value: 1.49e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967343    1 MVLGFLGCCGAVKESRCMLLLFFIGLLLILILQVAAGILGAAFKPEYNRILNETLYENAKL-LSDNTDEAKDFQKAMIVF 79
Cdd:pfam00335  56 FLVGFLGCCGALKENRCLLLTYFVLLLLLFLAELAAGILAFVYRDKLSGLLSNWLKKSLEDgYRDWLDLYSCLNSALDSL 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967343   80 QSEFKCCGlengaadwgnnfveakescqctgtdcatyqgssvypkTCLSLIKDLFEKNIIIVIGIAFGLAVIEILGLVFS 159
Cdd:pfam00335 136 QSEFGCCG-------------------------------------GCKEKLLEWLRKNLKIIGAGVIALGVIQLLGIILA 178


                  ....*
gi 568967343  160 MVLYC 164
Cdd:pfam00335 179 CCLCC 183
 
Name Accession Description Interval E-value
TM4SF3_like_LEL cd03154
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF3_like subfamily. ...
 40-138 1.04e-34

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF3_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contaions transmembrane 4 superfamily 3 (TM4SF3) or D6.1a and related proteins. D6.1a associates with alpha6beta4 integrin and supports cell motility, it has been ascribed a role in tumor progression and metastasis.


Pssm-ID: 239407 [Multi-domain]  Cd Length: 100  Bit Score: 117.14  E-value: 1.04e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967343  40 GAAFKPEYNRILNETLYENAKLLSDNTDEAKDFQKAMIVFQSEFKCCGLENGAADWGNNFveaKESCQCTGTDCAT---- 115
Cdd:cd03154    1 GIVGAVYKPKIENELKEKNTKLLSLLGQNAKSVKKSLEKFQKELKCCGLVNGADDWGNDI---PASCNCTTTQSDCvvay 77

                         90       100
                 ....*....|....*....|...
gi 568967343 116 YQGSSVYPKTCLSLIKDLFEKNI 138
Cdd:cd03154   78 YGGSNVYKEPCISKIKDFLKKNL 100
Tetraspanin pfam00335
Tetraspanin family;
1-164 1.49e-15

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 70.43  E-value: 1.49e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967343    1 MVLGFLGCCGAVKESRCMLLLFFIGLLLILILQVAAGILGAAFKPEYNRILNETLYENAKL-LSDNTDEAKDFQKAMIVF 79
Cdd:pfam00335  56 FLVGFLGCCGALKENRCLLLTYFVLLLLLFLAELAAGILAFVYRDKLSGLLSNWLKKSLEDgYRDWLDLYSCLNSALDSL 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967343   80 QSEFKCCGlengaadwgnnfveakescqctgtdcatyqgssvypkTCLSLIKDLFEKNIIIVIGIAFGLAVIEILGLVFS 159
Cdd:pfam00335 136 QSEFGCCG-------------------------------------GCKEKLLEWLRKNLKIIGAGVIALGVIQLLGIILA 178


                  ....*
gi 568967343  160 MVLYC 164
Cdd:pfam00335 179 CCLCC 183
tetraspanin_LEL cd03127
Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are ...
 41-138 2.73e-11

Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. The tetraspanin family contains CD9, CD63, CD37, CD53, CD82, CD151, and CD81, amongst others. Tetraspanins are involved in diverse processes such as cell activation and proliferation, adhesion and motility, differentiation, cancer, and others. Their various functions may relate to their ability to act as molecular facilitators, grouping specific cell-surface proteins and affecting formation and stability of signaling complexes. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web", which may also include integrins.


Pssm-ID: 239401 [Multi-domain]  Cd Length: 90  Bit Score: 56.74  E-value: 2.73e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967343  41 AAFKPEYNRILNETLYENAKLLSDNtdeaKDFQKAMIVFQSEFKCCGLeNGAADWGNNFVEAKESCqCTGTDCATyqGSS 120
Cdd:cd03127    1 FVYRDQLESLVSDTLNDAWDEYYVD----DDFQEAMDALQSTFECCGV-NGPTDYLDLRLLVPSSC-CKGTDGNC--GLN 72

                         90
                 ....*....|....*...
gi 568967343 121 VYPKTCLSLIKDLFEKNI 138
Cdd:cd03127   73 LYTEGCLEKLVDFLRSNL 90
CD53_like_LEL cd03164
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD53_Like family. ...
 65-137 2.31e-04

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD53_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD53 is a tetraspanin of the lymphoid-myeloid lineage and has been implicated in apoptosis protection. It associates with integrin alpha4beta1. Some of the cellular responses modulated by CD53 may be mediated by JNK activation and/or via the AKT pathway.


Pssm-ID: 239417 [Multi-domain]  Cd Length: 86  Bit Score: 38.23  E-value: 2.31e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568967343  65 NTDEAKDFqkamivFQSEFKCCGLeNGAADWGNnfvEAKESCQCTGTDcatyqgssVYPKTCLSLIKDLFEKN 137
Cdd:cd03164   27 NTSEAWDM------IQSNLQCCGI-NGTTDWGS---GVPSSCCSSDTE--------YKVEGCYKKLKNWFESN 81
CD63_LEL cd03166
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins ...
 70-138 1.40e-03

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD63 is present in platelets, neutrophils, and endothelial cells, amongst others. In platelets it associates with the integrin alphaIIBbeta3 and may modulate alphaIIbbeta3-dependent cytoskeletal reorganization.


Pssm-ID: 239419  Cd Length: 99  Bit Score: 36.30  E-value: 1.40e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568967343  70 KDFQKAMIVFQSEFKCCGLENgAADWGNNFVEAKES-----CQCTGTDCAT-YQGSSVYPKTCLSLIKDLFEKNI 138
Cdd:cd03166   26 NDFRKILDRMQKDLKCCGANN-YTDWENIPSLDTDSvpdscCINVTKGCGInFDEKVIHLEGCVTKIEGWLKKNI 99
NET-5_like_LEL cd03165
Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. ...
 80-138 8.48e-03

Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This sub-family contains proteins similar to human tetraspan NET-5.


Pssm-ID: 239418 [Multi-domain]  Cd Length: 98  Bit Score: 34.26  E-value: 8.48e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568967343  80 QSEFKCCGLENgAADWGNNFVEAK--ESCqCTGT--DCATYQGSSVYPKTCLSLIKDLFEKNI 138
Cdd:cd03165   38 QTEFRCCGVTN-YTDWYEVLGENRvpDSC-CQEDsqDCGRNPTELWWKTGCYEKVQQWLVDNL 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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