|
Name |
Accession |
Description |
Interval |
E-value |
| PHA03247 super family |
cl33720 |
large tegument protein UL36; Provisional |
434-842 |
1.20e-12 |
|
large tegument protein UL36; Provisional
The actual alignment was detected with superfamily member PHA03247:
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 72.66 E-value: 1.20e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 434 PPPRAVISSSPPPLIQNMPPNQASSA------TLPQETLSAMPF-----SPAPLSLASSPPQLLPSPPISPQNLPTSLVT 502
Cdd:PHA03247 2559 APPAAPDRSVPPPRPAPRPSEPAVTSrarrpdAPPQSARPRAPVddrgdPRGPAPPSPLPPDTHAPDPPPPSPSPAANEP 2638
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 503 SSQLPLSTPFRANFSESPPLPRATLANRTTPSLQDPLflAISPPVSSSTSISPPL--PTSSVVTPPLRLPLSQTLPTSQA 580
Cdd:PHA03247 2639 DPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQ--ASSPPQRPRRRAARPTvgSLTSLADPPPPPPTPEPAPHALV 2716
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 581 SLLTLPPSLASSPQPATPPPLALSPLSTQLSTGSPSLQASPSFLPTPPMQPRALPSPSLQAPPVTYPLPLSSPPASPPLP 660
Cdd:PHA03247 2717 SATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRE 2796
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 661 ALLSPPASPPLESPLSPSASPSSPLATP-PPEAPPSLGSPTLSPLATPPPQTPPLAF-----------PPLPASTSSLDT 728
Cdd:PHA03247 2797 SLPSPWDPADPPAAVLAPAAALPPAASPaGPLPPPTSAQPTAPPPPPGPPPPSLPLGgsvapggdvrrRPPSRSPAAKPA 2876
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 729 ATCFPQGPLLALPPLQTSPSPLTIPCPQTPPSLALPSLQSPSSPLATATPPLQIPLVVLPTLQTPPSPLTTFPPGVPPGL 808
Cdd:PHA03247 2877 APARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPS 2956
|
410 420 430
....*....|....*....|....*....|....*
gi 568953557 809 TSPVVQPPSPPASPPLQAPR-RPPTPGPDVPITGP 842
Cdd:PHA03247 2957 GAVPQPWLGALVPGRVAVPRfRVPQPAPSREAPAS 2991
|
|
| PHA03247 super family |
cl33720 |
large tegument protein UL36; Provisional |
12-620 |
4.09e-11 |
|
large tegument protein UL36; Provisional
The actual alignment was detected with superfamily member PHA03247:
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 67.66 E-value: 4.09e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 12 APRMPSSRPPGLLTPRPPsgsARPPPPVTTAALRVLEangAMGRRSLVERAPGVCKAALPQTSKAALPQTSKAALPQTSK 91
Cdd:PHA03247 2508 APPAPSRLAPAILPDEPV---GEPVHPRMLTWIRGLE---ELASDDAGDPPPPLPPAAPPAAPDRSVPPPRPAPRPSEPA 2581
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 92 AALPQTSKAALPQTTIHGAPARSAGAGPRSPANRPPASGKGERAPMKTPGQGSISSPGRASSGIARPGPVVQKRLQPPTK 171
Cdd:PHA03247 2582 VTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRV 2661
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 172 EPSARGKTPETPKR-NTLNSGTRRVLSADSLGPTSGAPSPAITRRSRAPAtevglPQPAPSARQRPLTTEAARKPGSSAS 250
Cdd:PHA03247 2662 SRPRRARRLGRAAQaSSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPA-----PHALVSATPLPPGPAAARQASPALP 2736
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 251 EPSATELSPAFRRRSVAGGSLQKPVSRSLIPSATPQLSPSrSGVSPRVTPRAPAHTSQLKSKGQQALHPTQTTVPRKNKP 330
Cdd:PHA03247 2737 AAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPA-AGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPA 2815
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 331 SVQSLIPASSLVTPTPPGASSVQGPDDPSQTTLPPSPPTTPPLPASLQLLQPQASSQAVPHSQSG--QGSPSPPPLSLQN 408
Cdd:PHA03247 2816 AALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARppVRRLARPAVSRST 2895
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 409 LPSTPATPPLLAPPTSLDTEEASDSPPPRAVISSSPPPLIQNMPPNQASSATLPQETLSAMPFSPAPLSLASSPPQLLPS 488
Cdd:PHA03247 2896 ESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVP 2975
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 489 PPISPQNLPtslvtssqlPLSTPfranfsESPPLPRATLANRTTPSLQDPLFLAIS---PPVSSSTSISPPLPTSSVVTP 565
Cdd:PHA03247 2976 RFRVPQPAP---------SREAP------ASSTPPLTGHSLSRVSSWASSLALHEEtdpPPVSLKQTLWPPDDTEDSDAD 3040
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....*
gi 568953557 566 PLRLPLSQTLPTSQASLLTLPPSLASSPQPATPPPLALSPLSTQLSTGSPSLQAS 620
Cdd:PHA03247 3041 SLFDSDSERSDLEALDPLPPEPHDPFAHEPDPATPEAGARESPSSQFGPPPLSAN 3095
|
|
| DUF4596 |
pfam15363 |
Domain of unknown function (DUF4596); This domain family is found in eukaryotes, and is ... |
1056-1098 |
7.96e-10 |
|
Domain of unknown function (DUF4596); This domain family is found in eukaryotes, and is approximately 50 amino acids in length. There is a conserved ELET sequence motif. There are two completely conserved residues (S and E) that may be functionally important.
:
Pssm-ID: 464673 Cd Length: 46 Bit Score: 55.31 E-value: 7.96e-10
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 568953557 1056 RWAELLSPLDESRASITsVTSFSPDDVASPQGDWTVVEVETFH 1098
Cdd:pfam15363 5 RWSELSSPLDDSSASIT-VTSFSPEDGCSPQGEWTILELETQH 46
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
434-842 |
1.20e-12 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 72.66 E-value: 1.20e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 434 PPPRAVISSSPPPLIQNMPPNQASSA------TLPQETLSAMPF-----SPAPLSLASSPPQLLPSPPISPQNLPTSLVT 502
Cdd:PHA03247 2559 APPAAPDRSVPPPRPAPRPSEPAVTSrarrpdAPPQSARPRAPVddrgdPRGPAPPSPLPPDTHAPDPPPPSPSPAANEP 2638
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 503 SSQLPLSTPFRANFSESPPLPRATLANRTTPSLQDPLflAISPPVSSSTSISPPL--PTSSVVTPPLRLPLSQTLPTSQA 580
Cdd:PHA03247 2639 DPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQ--ASSPPQRPRRRAARPTvgSLTSLADPPPPPPTPEPAPHALV 2716
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 581 SLLTLPPSLASSPQPATPPPLALSPLSTQLSTGSPSLQASPSFLPTPPMQPRALPSPSLQAPPVTYPLPLSSPPASPPLP 660
Cdd:PHA03247 2717 SATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRE 2796
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 661 ALLSPPASPPLESPLSPSASPSSPLATP-PPEAPPSLGSPTLSPLATPPPQTPPLAF-----------PPLPASTSSLDT 728
Cdd:PHA03247 2797 SLPSPWDPADPPAAVLAPAAALPPAASPaGPLPPPTSAQPTAPPPPPGPPPPSLPLGgsvapggdvrrRPPSRSPAAKPA 2876
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 729 ATCFPQGPLLALPPLQTSPSPLTIPCPQTPPSLALPSLQSPSSPLATATPPLQIPLVVLPTLQTPPSPLTTFPPGVPPGL 808
Cdd:PHA03247 2877 APARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPS 2956
|
410 420 430
....*....|....*....|....*....|....*
gi 568953557 809 TSPVVQPPSPPASPPLQAPR-RPPTPGPDVPITGP 842
Cdd:PHA03247 2957 GAVPQPWLGALVPGRVAVPRfRVPQPAPSREAPAS 2991
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
12-620 |
4.09e-11 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 67.66 E-value: 4.09e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 12 APRMPSSRPPGLLTPRPPsgsARPPPPVTTAALRVLEangAMGRRSLVERAPGVCKAALPQTSKAALPQTSKAALPQTSK 91
Cdd:PHA03247 2508 APPAPSRLAPAILPDEPV---GEPVHPRMLTWIRGLE---ELASDDAGDPPPPLPPAAPPAAPDRSVPPPRPAPRPSEPA 2581
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 92 AALPQTSKAALPQTTIHGAPARSAGAGPRSPANRPPASGKGERAPMKTPGQGSISSPGRASSGIARPGPVVQKRLQPPTK 171
Cdd:PHA03247 2582 VTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRV 2661
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 172 EPSARGKTPETPKR-NTLNSGTRRVLSADSLGPTSGAPSPAITRRSRAPAtevglPQPAPSARQRPLTTEAARKPGSSAS 250
Cdd:PHA03247 2662 SRPRRARRLGRAAQaSSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPA-----PHALVSATPLPPGPAAARQASPALP 2736
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 251 EPSATELSPAFRRRSVAGGSLQKPVSRSLIPSATPQLSPSrSGVSPRVTPRAPAHTSQLKSKGQQALHPTQTTVPRKNKP 330
Cdd:PHA03247 2737 AAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPA-AGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPA 2815
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 331 SVQSLIPASSLVTPTPPGASSVQGPDDPSQTTLPPSPPTTPPLPASLQLLQPQASSQAVPHSQSG--QGSPSPPPLSLQN 408
Cdd:PHA03247 2816 AALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARppVRRLARPAVSRST 2895
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 409 LPSTPATPPLLAPPTSLDTEEASDSPPPRAVISSSPPPLIQNMPPNQASSATLPQETLSAMPFSPAPLSLASSPPQLLPS 488
Cdd:PHA03247 2896 ESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVP 2975
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 489 PPISPQNLPtslvtssqlPLSTPfranfsESPPLPRATLANRTTPSLQDPLFLAIS---PPVSSSTSISPPLPTSSVVTP 565
Cdd:PHA03247 2976 RFRVPQPAP---------SREAP------ASSTPPLTGHSLSRVSSWASSLALHEEtdpPPVSLKQTLWPPDDTEDSDAD 3040
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....*
gi 568953557 566 PLRLPLSQTLPTSQASLLTLPPSLASSPQPATPPPLALSPLSTQLSTGSPSLQAS 620
Cdd:PHA03247 3041 SLFDSDSERSDLEALDPLPPEPHDPFAHEPDPATPEAGARESPSSQFGPPPLSAN 3095
|
|
| DUF4596 |
pfam15363 |
Domain of unknown function (DUF4596); This domain family is found in eukaryotes, and is ... |
1056-1098 |
7.96e-10 |
|
Domain of unknown function (DUF4596); This domain family is found in eukaryotes, and is approximately 50 amino acids in length. There is a conserved ELET sequence motif. There are two completely conserved residues (S and E) that may be functionally important.
Pssm-ID: 464673 Cd Length: 46 Bit Score: 55.31 E-value: 7.96e-10
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 568953557 1056 RWAELLSPLDESRASITsVTSFSPDDVASPQGDWTVVEVETFH 1098
Cdd:pfam15363 5 RWSELSSPLDDSSASIT-VTSFSPEDGCSPQGEWTILELETQH 46
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
381-779 |
6.77e-03 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 40.52 E-value: 6.77e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 381 QPQASSQAVPHSQSGQGSPSPPPLSLQNLPSTPATPPLLAPPTSLDTEEASDSPPPRAVISSSPP-PLIQNMPPNQASSA 459
Cdd:pfam03154 163 QQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPhTLIQQTPTLHPQRL 242
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 460 TLPQETLSAMPFSPAPlslassppqllpsPPISPQNLPTSLVTSSQLPLSTPFRANFSESPPLPRATLANRTTPSLQDPL 539
Cdd:pfam03154 243 PSPHPPLQPMTQPPPP-------------SQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPVPPQPFPLTPQSSQSQV 309
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 540 FLAISPPVSSSTSISPPLPTSSVVTPPLRLPLSQTLPTSQASLL------TLPPSLASSPQPATPPPLALSPLSTQLSTG 613
Cdd:pfam03154 310 PPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPhikpppTTPIPQLPNPQSHKHPPHLSGPSPFQMNSN 389
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 614 SPSLQASPSFLPTPPMQPRALPSPSLQAPPvtYPLPLSSPPASPPLPALLSPPASPPLESPLSPSASPSSPLATPPPEAP 693
Cdd:pfam03154 390 LPPPPALKPLSSLSTHHPPSAHPPPLQLMP--QSQQLPPPPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHPF 467
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 694 PSLGSPTLSPLATPPPQTPPLAFPPLPASTSSLDTATCFPQGPLLALPPLQTSPSPLTIP-CPQTPPslalPSLQSPSSP 772
Cdd:pfam03154 468 VPGGPPPITPPSGPPTSTSSAMPGIQPPSSASVSSSGPVPAAVSCPLPPVQIKEEALDEAeEPESPP----PPPRSPSPE 543
|
....*..
gi 568953557 773 LATATPP 779
Cdd:pfam03154 544 PTVVNTP 550
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
434-842 |
1.20e-12 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 72.66 E-value: 1.20e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 434 PPPRAVISSSPPPLIQNMPPNQASSA------TLPQETLSAMPF-----SPAPLSLASSPPQLLPSPPISPQNLPTSLVT 502
Cdd:PHA03247 2559 APPAAPDRSVPPPRPAPRPSEPAVTSrarrpdAPPQSARPRAPVddrgdPRGPAPPSPLPPDTHAPDPPPPSPSPAANEP 2638
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 503 SSQLPLSTPFRANFSESPPLPRATLANRTTPSLQDPLflAISPPVSSSTSISPPL--PTSSVVTPPLRLPLSQTLPTSQA 580
Cdd:PHA03247 2639 DPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQ--ASSPPQRPRRRAARPTvgSLTSLADPPPPPPTPEPAPHALV 2716
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 581 SLLTLPPSLASSPQPATPPPLALSPLSTQLSTGSPSLQASPSFLPTPPMQPRALPSPSLQAPPVTYPLPLSSPPASPPLP 660
Cdd:PHA03247 2717 SATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRE 2796
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 661 ALLSPPASPPLESPLSPSASPSSPLATP-PPEAPPSLGSPTLSPLATPPPQTPPLAF-----------PPLPASTSSLDT 728
Cdd:PHA03247 2797 SLPSPWDPADPPAAVLAPAAALPPAASPaGPLPPPTSAQPTAPPPPPGPPPPSLPLGgsvapggdvrrRPPSRSPAAKPA 2876
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 729 ATCFPQGPLLALPPLQTSPSPLTIPCPQTPPSLALPSLQSPSSPLATATPPLQIPLVVLPTLQTPPSPLTTFPPGVPPGL 808
Cdd:PHA03247 2877 APARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPS 2956
|
410 420 430
....*....|....*....|....*....|....*
gi 568953557 809 TSPVVQPPSPPASPPLQAPR-RPPTPGPDVPITGP 842
Cdd:PHA03247 2957 GAVPQPWLGALVPGRVAVPRfRVPQPAPSREAPAS 2991
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
12-620 |
4.09e-11 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 67.66 E-value: 4.09e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 12 APRMPSSRPPGLLTPRPPsgsARPPPPVTTAALRVLEangAMGRRSLVERAPGVCKAALPQTSKAALPQTSKAALPQTSK 91
Cdd:PHA03247 2508 APPAPSRLAPAILPDEPV---GEPVHPRMLTWIRGLE---ELASDDAGDPPPPLPPAAPPAAPDRSVPPPRPAPRPSEPA 2581
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 92 AALPQTSKAALPQTTIHGAPARSAGAGPRSPANRPPASGKGERAPMKTPGQGSISSPGRASSGIARPGPVVQKRLQPPTK 171
Cdd:PHA03247 2582 VTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRV 2661
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 172 EPSARGKTPETPKR-NTLNSGTRRVLSADSLGPTSGAPSPAITRRSRAPAtevglPQPAPSARQRPLTTEAARKPGSSAS 250
Cdd:PHA03247 2662 SRPRRARRLGRAAQaSSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPA-----PHALVSATPLPPGPAAARQASPALP 2736
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 251 EPSATELSPAFRRRSVAGGSLQKPVSRSLIPSATPQLSPSrSGVSPRVTPRAPAHTSQLKSKGQQALHPTQTTVPRKNKP 330
Cdd:PHA03247 2737 AAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPA-AGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPA 2815
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 331 SVQSLIPASSLVTPTPPGASSVQGPDDPSQTTLPPSPPTTPPLPASLQLLQPQASSQAVPHSQSG--QGSPSPPPLSLQN 408
Cdd:PHA03247 2816 AALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARppVRRLARPAVSRST 2895
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 409 LPSTPATPPLLAPPTSLDTEEASDSPPPRAVISSSPPPLIQNMPPNQASSATLPQETLSAMPFSPAPLSLASSPPQLLPS 488
Cdd:PHA03247 2896 ESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVP 2975
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 489 PPISPQNLPtslvtssqlPLSTPfranfsESPPLPRATLANRTTPSLQDPLFLAIS---PPVSSSTSISPPLPTSSVVTP 565
Cdd:PHA03247 2976 RFRVPQPAP---------SREAP------ASSTPPLTGHSLSRVSSWASSLALHEEtdpPPVSLKQTLWPPDDTEDSDAD 3040
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....*
gi 568953557 566 PLRLPLSQTLPTSQASLLTLPPSLASSPQPATPPPLALSPLSTQLSTGSPSLQAS 620
Cdd:PHA03247 3041 SLFDSDSERSDLEALDPLPPEPHDPFAHEPDPATPEAGARESPSSQFGPPPLSAN 3095
|
|
| DUF4596 |
pfam15363 |
Domain of unknown function (DUF4596); This domain family is found in eukaryotes, and is ... |
1056-1098 |
7.96e-10 |
|
Domain of unknown function (DUF4596); This domain family is found in eukaryotes, and is approximately 50 amino acids in length. There is a conserved ELET sequence motif. There are two completely conserved residues (S and E) that may be functionally important.
Pssm-ID: 464673 Cd Length: 46 Bit Score: 55.31 E-value: 7.96e-10
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 568953557 1056 RWAELLSPLDESRASITsVTSFSPDDVASPQGDWTVVEVETFH 1098
Cdd:pfam15363 5 RWSELSSPLDDSSASIT-VTSFSPEDGCSPQGEWTILELETQH 46
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
119-715 |
1.57e-07 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 56.10 E-value: 1.57e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 119 PRSPANRPPASGKGERAPMKTPGQGSISSPGRAssgiARPGPVVQKrlqpPTKEPSARGKTPETPKRNTLNSGTRRVLSA 198
Cdd:PHA03247 2475 PGAPVYRRPAEARFPFAAGAAPDPGGGGPPDPD----APPAPSRLA----PAILPDEPVGEPVHPRMLTWIRGLEELASD 2546
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 199 DSLGPTSGAPSPAitrRSRAPATEVGLPQPAPSARQRPLTTEAAR----------------------KPGSSASEPSATE 256
Cdd:PHA03247 2547 DAGDPPPPLPPAA---PPAAPDRSVPPPRPAPRPSEPAVTSRARRpdappqsarprapvddrgdprgPAPPSPLPPDTHA 2623
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 257 LSPAFRRRSVAGGSLQKPVSRSLIPSATPQLSPSRSGVSPRVTPRAPAHTSQLKSKGQ----QALHPTQTTVPRKNKPSV 332
Cdd:PHA03247 2624 PDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQrprrRAARPTVGSLTSLADPPP 2703
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 333 QSLIPASSlVTPTPPGASSVQGPDDPSQTTLPPSPPTTPPLPASLQLLQPQASSQAVPHSQSGQGSPSPPPLSLQNLPST 412
Cdd:PHA03247 2704 PPPTPEPA-PHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRR 2782
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 413 PATPPLLAPPTSLDTEEASDSPPPRAVISSSPPPliqNMPPNQASSATLPQETlSAMPFSPAPLSlASSPPQLLPSPPIS 492
Cdd:PHA03247 2783 LTRPAVASLSESRESLPSPWDPADPPAAVLAPAA---ALPPAASPAGPLPPPT-SAQPTAPPPPP-GPPPPSLPLGGSVA 2857
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 493 P----QNLPTSLVTSSQLPLSTPFRANFSESPPLPRATLANRTTPSLQDPLFLAISPPVSSSTSISPPLPTSSVVTPPLR 568
Cdd:PHA03247 2858 PggdvRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPP 2937
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 569 LPLSQTLPTSQASLLTLPPSLASSPQPATPPPLALSPLSTQLSTGSPSLQASPSflPTPPMQPRALPSPSLQAPPVTYPL 648
Cdd:PHA03247 2938 RPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPAS--STPPLTGHSLSRVSSWASSLALHE 3015
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568953557 649 PLSSPPASPPLPALLSPPASPPLESPLSPSASPSSPLATPPPEAPPSLGSPTLSPLATPPP----QTPPLA 715
Cdd:PHA03247 3016 ETDPPPVSLKQTLWPPDDTEDSDADSLFDSDSERSDLEALDPLPPEPHDPFAHEPDPATPEagarESPSSQ 3086
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
11-405 |
4.11e-06 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 51.48 E-value: 4.11e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 11 TAPRMPSSRPPGLLTPRPPSGSARPPPPVTTAALRVLEANGAMGRRSLVERAPGVCKAALPQTSKAALPQTSKAALPQTS 90
Cdd:PHA03247 2715 LVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSES 2794
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 91 KAALPQTSKAALPQTTIHG-APARSAGAGPRSPANRPPASGKGERAPMKTPGQGSISSPGrassGIARPGPVvqkRLQPP 169
Cdd:PHA03247 2795 RESLPSPWDPADPPAAVLApAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGG----SVAPGGDV---RRRPP 2867
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 170 TKEPSARGKTPETPK-RNTLNSGTRRVLSADSLGPTSGA--PSPAITRRSRAPATEVGLPQPAPSARQRPLTTEAARKPG 246
Cdd:PHA03247 2868 SRSPAAKPAAPARPPvRRLARPAVSRSTESFALPPDQPErpPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTT 2947
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 247 SSASEPSATELSPAFRRRSVAGGSLqkPVSRSLIPSATPQLSPSRSGVSPRVTPRAPAHTSQLKSkgqQALHPTQTTVPR 326
Cdd:PHA03247 2948 DPAGAGEPSGAVPQPWLGALVPGRV--AVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSSWASS---LALHEETDPPPV 3022
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568953557 327 KNKpsvQSLIPASSLVTPTPPGASSVQGPDDPSQTTLPPSPPTTPPLPASLQLLQPQASSQAVPHSQSGqgspsPPPLS 405
Cdd:PHA03247 3023 SLK---QTLWPPDDTEDSDADSLFDSDSERSDLEALDPLPPEPHDPFAHEPDPATPEAGARESPSSQFG-----PPPLS 3093
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
12-215 |
7.78e-05 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 46.79 E-value: 7.78e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 12 APRMPSSRPPGLLTPRPPSGSARPPPPVTTAALRVLEANGAMGRRSLVERAPGVCKAALPQTSKAALPQTSKAALPqtSK 91
Cdd:PRK12323 383 AQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPAPAPAAAP--AA 460
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 92 AALPQTSKAALPQTTIHGAPARSAGAGPRSPANR--PPASGKGERAPMKTPGQGSISSPGRASSGIARPGPVVQKRLQPP 169
Cdd:PRK12323 461 AARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDdpPPWEELPPEFASPAPAQPDAAPAGWVAESIPDPATADPDDAFET 540
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 568953557 170 TKEPSARGKTPETPKRNT-LNSGTRRVLSADSLGPTSGAPSPAITRR 215
Cdd:PRK12323 541 LAPAPAAAPAPRAAAATEpVVAPRPPRASASGLPDMFDGDWPALAAR 587
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
11-256 |
9.04e-05 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 46.70 E-value: 9.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 11 TAPRMPSSRPPGLLTPRPPSGSARPPPPVTTAALRVLEANGAMGRRSLVERAPGVCKAALPQTSKAALPQTSKAALPQTS 90
Cdd:PHA03307 182 TARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPA 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 91 KAALP---QTSKAALPQTTIHGAPARSAGAGPRSPANRPPASGKGERAPMKTPGQGSISSPGRASSGIARPGPVVQKRLQ 167
Cdd:PHA03307 262 PITLPtriWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAV 341
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 168 PPTKEPSARGKTPETPKRNTLNSGTRRVLSADSLGPTSGAPSPAITRRSRAPATEVGLPQPAPSARQRPLTTEAARKPGS 247
Cdd:PHA03307 342 SPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGRFPAGRPRPSPLDAGA 421
|
....*....
gi 568953557 248 SASEPSATE 256
Cdd:PHA03307 422 ASGAFYARY 430
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
555-988 |
1.19e-04 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 46.47 E-value: 1.19e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 555 PPLPTSSVVTPPlrlplSQTLPTSQASLLTLPPSLASSPQPATPPPLALSPLSTQLSTGSPSLQASPSFLP---TPPMQP 631
Cdd:PHA03247 2553 PPLPPAAPPAAP-----DRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPpdtHAPDPP 2627
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 632 RALPSPSLQAPPVTYPLPLSSPPASPPLPALLSPPASPPLESPLSPSASPSSPLATPPPEAPPSLGSptLSPLATPPPQt 711
Cdd:PHA03247 2628 PPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGS--LTSLADPPPP- 2704
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 712 pPLAFPPLPASTSSLDTATCFPQGPLLALPPLQTSPSPLTIPC----------PQTPPSLALP-SLQSPSSPLATATPPL 780
Cdd:PHA03247 2705 -PPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAgpatpggparPARPPTTAGPpAPAPPAAPAAGPPRRL 2783
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 781 QIPLVVLPTLQTPPSPLTTFPPGVPPGLTSPVVQPPSPPASPPLQAPRRPPTPGPDVPITGP------------------ 842
Cdd:PHA03247 2784 TRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPpppslplggsvapggdvr 2863
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 843 -RLTLALAPAPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGCPTISPAPDADLAACHPASWSRSSAPQLA 921
Cdd:PHA03247 2864 rRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPL 2943
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568953557 922 VRSTPGVPLPWPPTAGPGSSDGLCTIYESEGPESVAPTPGSLDVEPEPMPGSGSAKVTAADCAGASS 988
Cdd:PHA03247 2944 APTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSSWASS 3010
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
8-307 |
5.34e-04 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 44.39 E-value: 5.34e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 8 KSGTAPRMPSSRPPGLLTPRPPSGSARPPPPVTTAALRVLEAngamgrrslverAPGVCKAALPQTSKAALPQTSKAALP 87
Cdd:PHA03307 96 APASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEM------------LRPVGSPGPPPAASPPAAGASPAAVA 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 88 QTSKAALPQTSKAALPQTTIHGAPARSAGAGPRSPANRPPASGKGERAPMKTPGQGSISSPGRASSGIARPGPVVQKRLQ 167
Cdd:PHA03307 164 SDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSE 243
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 168 PPTKEPSARGKTPE-TPKRNTLNSGTRRVLSADSLGPTSGAPSPAITRRSRAPATEVGLPQPAPSARQRPLTTEAARKPG 246
Cdd:PHA03307 244 SSGCGWGPENECPLpRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRE 323
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568953557 247 SSASEPSATELSPafRRRSVAGGSLQKPVSRSLIPSATPQLSPSRSGVSPRVTPRAPAHTS 307
Cdd:PHA03307 324 SSSSSTSSSSESS--RGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASA 382
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
76-287 |
5.76e-04 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 44.10 E-value: 5.76e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 76 AALPQTSKAALPQTSKAALPQTSKAALPQTTIHGAPARSAGAGPRSPANRPPASGKGERAPMKTPGQGSISSPGRASSGI 155
Cdd:PRK12323 372 AGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPA 451
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 156 ARPGPVVQKRLQPPTKEPSARGKTPETPKRNTLNSGTRRVLSAD-----SLGPTSGAPSPAITRRSRAPATEVGLPQPAP 230
Cdd:PRK12323 452 PAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDpppweELPPEFASPAPAQPDAAPAGWVAESIPDPAT 531
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 568953557 231 SARQRPLTTEAARKPGSSASEPSATELSPAFRRRSVAGGSLQKPVSRSLIPSATPQL 287
Cdd:PRK12323 532 ADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPDMFDGDWPALAARL 588
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
24-250 |
1.43e-03 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 42.56 E-value: 1.43e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 24 LTPRPPSGSARPPPPvttAALRVLEANGAMGRRSLVERAPgvckaALPQTSKAALPQTSKAALPQTSKAALPQTSKAALP 103
Cdd:PRK12323 363 FRPGQSGGGAGPATA---AAAPVAQPAPAAAAPAAAAPAP-----AAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALA 434
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 104 QTtiHGAPARSAGAGPRSPANRPPASGKGERAPMKTPGQGSISSPGRASSGIARPGPVVQKRLQPPTKEPSArgkTPETP 183
Cdd:PRK12323 435 AA--RQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPP---EFASP 509
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568953557 184 KRNTLNSGTRRVLSADSLGPTSGAPSPAitrrsRAPATEVGLPQPAPSARQRPLTTEAARKPGSSAS 250
Cdd:PRK12323 510 APAQPDAAPAGWVAESIPDPATADPDDA-----FETLAPAPAAAPAPRAAAATEPVVAPRPPRASAS 571
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
109-446 |
1.74e-03 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 42.67 E-value: 1.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 109 GAPARSAGAGPRSPANRPPASGKGERAPMKTPGQGSISSPGRASSGIARPGPVVQKRLQPPTKEPSARGKTPETPKRNTL 188
Cdd:PRK07764 398 APSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEPT 477
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 189 nsgtrrvlSADSLGPTSGAPSPAITRRSRAPATEVGlPQPAPSARQ-----------RPLTTEAARKPGSSASEPSATEL 257
Cdd:PRK07764 478 --------AAPAPAPPAAPAPAAAPAAPAAPAAPAG-ADDAATLRErwpeilaavpkRSRKTWAILLPEATVLGVRGDTL 548
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 258 SPAFRR-------------------------------------RSVAGGSLQKPVSRSLIPSATPQLSPSRSGV-----S 295
Cdd:PRK07764 549 VLGFSTgglarrfaspgnaevlvtalaeelggdwqveavvgpaPGAAGGEGPPAPASSGPPEEAARPAAPAAPAapaapA 628
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 296 PRVTPRAPAHTSQLKSKGQQALHPTQTTVPRknkPSVQSLIPASSLVTPTPPGASSVQGPDDPSQTTLPPSPPTTPPLPA 375
Cdd:PRK07764 629 PAGAAAAPAEASAAPAPGVAAPEHHPKHVAV---PDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAP 705
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568953557 376 SLQLLQPQASSQAVPHSQSGQGSPSPPPLSLQNLPSTPATPPLLAPPTSLDTEEASDSPPPRAVISSSPPP 446
Cdd:PRK07764 706 AATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPP 776
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
586-1007 |
5.93e-03 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 41.08 E-value: 5.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 586 PPSLASSPQPATPPPLALSPLSTQLSTGSPSLQASPSFLPTPPMQPRALPSPSLQAPPvtyplplssppASPPLPALLSP 665
Cdd:PHA03247 2512 PSRLAPAILPDEPVGEPVHPRMLTWIRGLEELASDDAGDPPPPLPPAAPPAAPDRSVP-----------PPRPAPRPSEP 2580
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 666 PASPPLESPLSPSASPSSPLATPPPEAPPSLGSPTLSPLATPPPQTPPLAFPPLPASTSSLDTATCFPQgpllalPPLQT 745
Cdd:PHA03247 2581 AVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPP------ERPRD 2654
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 746 SPSPLTIPCPQTPPSLALPSlqSPSSPLATATPPLQIPLVV-LPTLQTPPSPltTFPPGVPPGLTSPVVQPPSPPASPPL 824
Cdd:PHA03247 2655 DPAPGRVSRPRRARRLGRAA--QASSPPQRPRRRAARPTVGsLTSLADPPPP--PPTPEPAPHALVSATPLPPGPAAARQ 2730
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 825 QAPRRPPTPGPDVPITGPRLTLALAPAPPPPPSRSPSSTLSGPDLAGHSSSATSTPeelrgydSGPEGCPTISPAPDADL 904
Cdd:PHA03247 2731 ASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRP-------AVASLSESRESLPSPWD 2803
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 905 AACHPASWSrSSAPQLAVRSTPGVPLPWPPTAGPGSSdglctiyesegPESVAPTPGSLDVEPEPMPGSGSAKVTAADCA 984
Cdd:PHA03247 2804 PADPPAAVL-APAAALPPAASPAGPLPPPTSAQPTAP-----------PPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSP 2871
|
410 420
....*....|....*....|...
gi 568953557 985 GASSRSPKSARLGELPLGALQAS 1007
Cdd:PHA03247 2872 AAKPAAPARPPVRRLARPAVSRS 2894
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
381-779 |
6.77e-03 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 40.52 E-value: 6.77e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 381 QPQASSQAVPHSQSGQGSPSPPPLSLQNLPSTPATPPLLAPPTSLDTEEASDSPPPRAVISSSPP-PLIQNMPPNQASSA 459
Cdd:pfam03154 163 QQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPhTLIQQTPTLHPQRL 242
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 460 TLPQETLSAMPFSPAPlslassppqllpsPPISPQNLPTSLVTSSQLPLSTPFRANFSESPPLPRATLANRTTPSLQDPL 539
Cdd:pfam03154 243 PSPHPPLQPMTQPPPP-------------SQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPVPPQPFPLTPQSSQSQV 309
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 540 FLAISPPVSSSTSISPPLPTSSVVTPPLRLPLSQTLPTSQASLL------TLPPSLASSPQPATPPPLALSPLSTQLSTG 613
Cdd:pfam03154 310 PPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPhikpppTTPIPQLPNPQSHKHPPHLSGPSPFQMNSN 389
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 614 SPSLQASPSFLPTPPMQPRALPSPSLQAPPvtYPLPLSSPPASPPLPALLSPPASPPLESPLSPSASPSSPLATPPPEAP 693
Cdd:pfam03154 390 LPPPPALKPLSSLSTHHPPSAHPPPLQLMP--QSQQLPPPPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHPF 467
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568953557 694 PSLGSPTLSPLATPPPQTPPLAFPPLPASTSSLDTATCFPQGPLLALPPLQTSPSPLTIP-CPQTPPslalPSLQSPSSP 772
Cdd:pfam03154 468 VPGGPPPITPPSGPPTSTSSAMPGIQPPSSASVSSSGPVPAAVSCPLPPVQIKEEALDEAeEPESPP----PPPRSPSPE 543
|
....*..
gi 568953557 773 LATATPP 779
Cdd:pfam03154 544 PTVVNTP 550
|
|
| |
