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Conserved domains on  [gi|568950209|ref|XP_006507689|]
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BRCA2-interacting transcriptional repressor EMSY isoform X13 [Mus musculus]

Protein Classification

ENT and PHA03247 domain-containing protein( domain architecture ID 13690837)

ENT and PHA03247 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ENT pfam03735
ENT domain; This presumed domain is named after Emsy N Terminus (ENT). Emsy is a protein that ...
 17-81 5.82e-28

ENT domain; This presumed domain is named after Emsy N Terminus (ENT). Emsy is a protein that is amplified in breast cancer and interacts with BRCA2. The N terminus of this protein is found to be similar to other vertebrate and plant proteins of unknown function. This domain has a completely conserved histidine residue that may be functionally important.


:

Pssm-ID: 461032  Cd Length: 71  Bit Score: 107.65  E-value: 5.82e-28
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568950209    17 KRILRKLELEAYAGVISALRAQGD-LTKEKKDLLGELSKVLSISTERHRAEVRRAVNDERLTTIAH 81
Cdd:pfam03735    1 KRQLRKLELEAYSSVLRAFRAQGDaLSWEKEKLLTELRKELNISDERHRAELRRVVNDERLKTIRE 66
PABP-1234 super family cl31127
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 896-1039 1.67e-04

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


The actual alignment was detected with superfamily member TIGR01628:

Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 45.95  E-value: 1.67e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950209   896 KQQKLSQPQLEQTQLQVKTLQCFQTKQKQTIHLQ-ADQLQHKLTQMPQLSIRHQKLNPL---QQEQAQPKPDAQHTQHTV 971
Cdd:TIGR01628  364 KEQRRAHLQDQFMQLQPRMRQLPMGSPMGGAMGQpPYYGQGPQQQFNGQPLGWPRMSMMptpMGPGGPLRPNGLAPMNAV 443

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568950209   972 VAKDRQLPTLMAQPPQTVVQvlAVKTTQQLPKLQQAPNQPKIYVQpqtpQSQMALPSSEKQPASQVEQ 1039
Cdd:TIGR01628  444 RAPSRNAQNAAQKPPMQPVM--YPPNYQSLPLSQDLPQPQSTASQ----GGQNKKLAQVLASATPQMQ 505
COG3889 super family cl28569
Extracellular solute-binding protein, contains Ig-fold domain [General function prediction ...
 484-585 3.05e-04

Extracellular solute-binding protein, contains Ig-fold domain [General function prediction only];


The actual alignment was detected with superfamily member COG3889:

Pssm-ID: 443097 [Multi-domain]  Cd Length: 878  Bit Score: 45.02  E-value: 3.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950209  484 LPKPVTATLPTSSNSPIMVVSSNGAIM----TTKLVTTPTGTQATYTRPTVSPSLGRVATT-----------PGAATYVK 548
Cdd:COG3889   758 LPAEVTAKLSPGSYTLVVIAYSELVALpaiyTTSFIVTPAVTIAVSTTIQTLTDTDTTTTTsakttpslttaATTTTTST 837

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 568950209  549 TTSGSIITVVPKSLATLGGKIISSNIVSGTTTKITTI 585
Cdd:COG3889   838 TTSTTSVTTTAAALASAATAAIVVGVVAVAVAIATAI 874
 
Name Accession Description Interval E-value
ENT pfam03735
ENT domain; This presumed domain is named after Emsy N Terminus (ENT). Emsy is a protein that ...
 17-81 5.82e-28

ENT domain; This presumed domain is named after Emsy N Terminus (ENT). Emsy is a protein that is amplified in breast cancer and interacts with BRCA2. The N terminus of this protein is found to be similar to other vertebrate and plant proteins of unknown function. This domain has a completely conserved histidine residue that may be functionally important.


Pssm-ID: 461032  Cd Length: 71  Bit Score: 107.65  E-value: 5.82e-28
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568950209    17 KRILRKLELEAYAGVISALRAQGD-LTKEKKDLLGELSKVLSISTERHRAEVRRAVNDERLTTIAH 81
Cdd:pfam03735    1 KRQLRKLELEAYSSVLRAFRAQGDaLSWEKEKLLTELRKELNISDERHRAELRRVVNDERLKTIRE 66
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 896-1039 1.67e-04

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 45.95  E-value: 1.67e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950209   896 KQQKLSQPQLEQTQLQVKTLQCFQTKQKQTIHLQ-ADQLQHKLTQMPQLSIRHQKLNPL---QQEQAQPKPDAQHTQHTV 971
Cdd:TIGR01628  364 KEQRRAHLQDQFMQLQPRMRQLPMGSPMGGAMGQpPYYGQGPQQQFNGQPLGWPRMSMMptpMGPGGPLRPNGLAPMNAV 443

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568950209   972 VAKDRQLPTLMAQPPQTVVQvlAVKTTQQLPKLQQAPNQPKIYVQpqtpQSQMALPSSEKQPASQVEQ 1039
Cdd:TIGR01628  444 RAPSRNAQNAAQKPPMQPVM--YPPNYQSLPLSQDLPQPQSTASQ----GGQNKKLAQVLASATPQMQ 505
COG3889 COG3889
Extracellular solute-binding protein, contains Ig-fold domain [General function prediction ...
 484-585 3.05e-04

Extracellular solute-binding protein, contains Ig-fold domain [General function prediction only];


Pssm-ID: 443097 [Multi-domain]  Cd Length: 878  Bit Score: 45.02  E-value: 3.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950209  484 LPKPVTATLPTSSNSPIMVVSSNGAIM----TTKLVTTPTGTQATYTRPTVSPSLGRVATT-----------PGAATYVK 548
Cdd:COG3889   758 LPAEVTAKLSPGSYTLVVIAYSELVALpaiyTTSFIVTPAVTIAVSTTIQTLTDTDTTTTTsakttpslttaATTTTTST 837

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 568950209  549 TTSGSIITVVPKSLATLGGKIISSNIVSGTTTKITTI 585
Cdd:COG3889   838 TTSTTSVTTTAAALASAATAAIVVGVVAVAVAIATAI 874
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 932-1108 6.64e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 40.84  E-value: 6.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950209  932 QLQHKLTQMPQLSIRHQKLNPLQQEQAQPKPDAQHTQHTvvakdrqlptlmaQPPQTVVQVLAVKTTQQLPKLQQAPNQP 1011
Cdd:PRK10263  754 QPQQPVAPQQQYQQPQQPVAPQPQYQQPQQPVAPQPQYQ-------------QPQQPVAPQPQYQQPQQPVAPQPQYQQP 820

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950209 1012 KIYVQPQtPQSQMALPSSEKQPASQVEQPIITQgssvtkitfEGRQPPTVTKITGGSSVPKLTSPVTSISPIQASEKTAV 1091
Cdd:PRK10263  821 QQPVAPQ-PQYQQPQQPVAPQPQDTLLHPLLMR---------NGDSRPLHKPTTPLPSLDLLTPPPSEVEPVDTFALEQM 890

                         170
                  ....*....|....*..
gi 568950209 1092 SDILQMSLMEAQIDTNV 1108
Cdd:PRK10263  891 ARLVEARLADFRIKADV 907
 
Name Accession Description Interval E-value
ENT pfam03735
ENT domain; This presumed domain is named after Emsy N Terminus (ENT). Emsy is a protein that ...
 17-81 5.82e-28

ENT domain; This presumed domain is named after Emsy N Terminus (ENT). Emsy is a protein that is amplified in breast cancer and interacts with BRCA2. The N terminus of this protein is found to be similar to other vertebrate and plant proteins of unknown function. This domain has a completely conserved histidine residue that may be functionally important.


Pssm-ID: 461032  Cd Length: 71  Bit Score: 107.65  E-value: 5.82e-28
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568950209    17 KRILRKLELEAYAGVISALRAQGD-LTKEKKDLLGELSKVLSISTERHRAEVRRAVNDERLTTIAH 81
Cdd:pfam03735    1 KRQLRKLELEAYSSVLRAFRAQGDaLSWEKEKLLTELRKELNISDERHRAELRRVVNDERLKTIRE 66
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 896-1039 1.67e-04

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 45.95  E-value: 1.67e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950209   896 KQQKLSQPQLEQTQLQVKTLQCFQTKQKQTIHLQ-ADQLQHKLTQMPQLSIRHQKLNPL---QQEQAQPKPDAQHTQHTV 971
Cdd:TIGR01628  364 KEQRRAHLQDQFMQLQPRMRQLPMGSPMGGAMGQpPYYGQGPQQQFNGQPLGWPRMSMMptpMGPGGPLRPNGLAPMNAV 443

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568950209   972 VAKDRQLPTLMAQPPQTVVQvlAVKTTQQLPKLQQAPNQPKIYVQpqtpQSQMALPSSEKQPASQVEQ 1039
Cdd:TIGR01628  444 RAPSRNAQNAAQKPPMQPVM--YPPNYQSLPLSQDLPQPQSTASQ----GGQNKKLAQVLASATPQMQ 505
COG3889 COG3889
Extracellular solute-binding protein, contains Ig-fold domain [General function prediction ...
 484-585 3.05e-04

Extracellular solute-binding protein, contains Ig-fold domain [General function prediction only];


Pssm-ID: 443097 [Multi-domain]  Cd Length: 878  Bit Score: 45.02  E-value: 3.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950209  484 LPKPVTATLPTSSNSPIMVVSSNGAIM----TTKLVTTPTGTQATYTRPTVSPSLGRVATT-----------PGAATYVK 548
Cdd:COG3889   758 LPAEVTAKLSPGSYTLVVIAYSELVALpaiyTTSFIVTPAVTIAVSTTIQTLTDTDTTTTTsakttpslttaATTTTTST 837

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 568950209  549 TTSGSIITVVPKSLATLGGKIISSNIVSGTTTKITTI 585
Cdd:COG3889   838 TTSTTSVTTTAAALASAATAAIVVGVVAVAVAIATAI 874
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 932-1108 6.64e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 40.84  E-value: 6.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950209  932 QLQHKLTQMPQLSIRHQKLNPLQQEQAQPKPDAQHTQHTvvakdrqlptlmaQPPQTVVQVLAVKTTQQLPKLQQAPNQP 1011
Cdd:PRK10263  754 QPQQPVAPQQQYQQPQQPVAPQPQYQQPQQPVAPQPQYQ-------------QPQQPVAPQPQYQQPQQPVAPQPQYQQP 820

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950209 1012 KIYVQPQtPQSQMALPSSEKQPASQVEQPIITQgssvtkitfEGRQPPTVTKITGGSSVPKLTSPVTSISPIQASEKTAV 1091
Cdd:PRK10263  821 QQPVAPQ-PQYQQPQQPVAPQPQDTLLHPLLMR---------NGDSRPLHKPTTPLPSLDLLTPPPSEVEPVDTFALEQM 890

                         170
                  ....*....|....*..
gi 568950209 1092 SDILQMSLMEAQIDTNV 1108
Cdd:PRK10263  891 ARLVEARLADFRIKADV 907
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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