|
Name |
Accession |
Description |
Interval |
E-value |
| AKR_AKR1D1-3 |
cd19109 |
AKR1D family of aldo-keto reductase (AKR); The AKR1D family of aldo-keto reductase includes ... |
15-321 |
0e+00 |
|
AKR1D family of aldo-keto reductase (AKR); The AKR1D family of aldo-keto reductase includes 3-oxo-5-beta-steroid 4-dehydrogenase (EC 1.3.1.3) from Homo sapiens (AKR1D1), Rattus norvegicus (liver, AKR1D2), and Oryctolagus cuniculus (AKR1D3). 3-oxo-5-beta-steroid 4-dehydrogenase, also called delta(4)-3-ketosteroid 5-beta-reductase (EC 1.3.99.6), or delta(4)-3-oxosteroid 5-beta-reductase, or 5-beta-reductase, efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites.
Pssm-ID: 381335 [Multi-domain] Cd Length: 308 Bit Score: 643.39 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 15 GNNIPLIGLGTYSDPR-PVPGKTYVAVKTAIDEGYRHIDGAYVYHNEHEVGEAIREKIAEGKVKREEIFYCGKLWNTEHV 93
Cdd:cd19109 1 GNSIPIIGLGTYSEPKtTPKGACAEAVKVAIDTGYRHIDGAYIYQNEHEVGQAIREKIAEGKVKREDIFYCGKLWNTCHP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 94 PSMVLPALERTLKALKLDYIDLYIIELPMAFKPGKEIYPRDENGRIIYDKTNLCATWEALEACKDAGLVKSLGVSNFNRR 173
Cdd:cd19109 81 PELVRPTLERTLKVLQLDYVDLYIIEMPMAFKPGDEIYPRDENGKWLYHKTNLCATWEALEACKDAGLVKSIGVSNFNRR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 174 QLELILNKPGLKYKPVTNQVECHPYFTQTKLLKFCQQHDIVIVAHSPLGTCRNPSWVNVSSPPLLNDELLTSLGKKYNKT 253
Cdd:cd19109 161 QLELILNKPGLKHKPVSNQVECHPYFTQPKLLEFCQQHDIVIVAYSPLGTCRDPIWVNVSSPPLLEDPLLNSIGKKYNKT 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568941248 254 QAQIVLRFNIQRGIVVIPKSFTPERIKENFQIFDFSLTEEEMKDIDALNKNVRYVELLMWSDHPEYPF 321
Cdd:cd19109 241 AAQVVLRFNIQRGVVVIPKSFNPERIKENFQIFDFSLTEEEMKDIEALNKNVRYVELLMWRDHPEYPF 308
|
|
| AKR_AKR1C1-35 |
cd19108 |
AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) ... |
8-308 |
0e+00 |
|
AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) includes AKR1C1 (20-alpha-hydroxysteroid dehydrogenase, also known as 20alpha-HSD), AKR1C2 (3alpha-HSD type 3), AKR1C3 (17beta-HSD type 5), and AKR1C4 (3alpha-HSD type 1) from Homo sapiens; AKR1C5 (20alpha-HSD, also known as prostaglandin-E(2) 9-reductase) from Rattus norvegicus (ovary); AKR1C6 (estradiol 17beta-HSD type 5) from Mus musculus; AKR1C7 (prostaglandin F synthase 1 or PGF1) from Bos taurus (lung); AKR1C8 (20alpha-HSD) from Rattus norvegicus (ovary); AKR1C9 (3alpha-HSD) from Rattus norvegicus (liver); AKR1C10a (Rho crystallin) from Rana temporaria and AKR1C10b (Rho crystallin) from Rana catesbeina; AKR1C11 (prostaglandin F synthase 2 or PGF2) from Bos taurus (liver); AKR1C12 (aldo-keto reductase or AKR), AKR1C13 (interleukin-3-regulated AKR), and AKR1C14 (3alpha-HSD) from Mus musculus; AKR1C15 (NADPH-dependent reductase), AKR1C16 (NAD+-preferring 3alpha/17beta/20alpha-HSD), and AKR1C17 (NAD+-dependent 3alpha-HSD) from Rattus norvegicus; AKR1C18 (20alpha-HSD), AKR1C19 (3-hydroxybutyrate dehydrogenase or 3HB dehydrogenase), AKR1C20 (3alpha(17beta)-HSD), AKR1C21 (3(17)alpha-HSD), AKR1C22 (dihydrodiol dehydrogenase or DD) from Mus musculus; AKR1C23 (20alpha-HSD) from Equus caballus; AKR1C24 (NAD+-dependent 17beta-HSD) from Rattus norvegicus; AKR1C25 (3(20)alpha-HSD) from Macaca fuscata; AKR1C26 (identical to morphine 6-dehydrogenase or M6DH, acts as NAD(+)-dependent 3alpha/17beta-HSD), AKR1C27/AKR1C28 (NAD(+)-dependent 3alpha/17beta-HSDs), AKR1C29 (identical to 3-hydroxyhexobarbital dehydrogenase or 3HBD, acts as NADPH-preferring reductase with 3alpha/3beta/17beta/20alpha-HSD activity), AKR1C30 (identical to naloxone reductase type 1 and acts as 17beta-HSD), AKR1C31 (3alpha/17beta/20alpha-HSD), AKR1C32 (identical to loxoprofen reductase and acts as 3alpha/20alpha-HSD), and AKR1C33 (identical to naloxone reductase type 2 and mainly acts as 3alpha-HSD) from Oryctolagus cuniculus; AKR1C34 (NAD+-dependent morphine 6-dehydrogenase or M6DH with 3beta/17beta/20alpha-HSD activity) and AKR1C35 (NAD+-dependent dehydrogenase with 3(17)beta-HSD activity) from Mesocricetus auratus.
Pssm-ID: 381334 [Multi-domain] Cd Length: 303 Bit Score: 504.46 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 8 HQISLSDGNNIPLIGLGTYSdPRPVP-GKTYVAVKTAIDEGYRHIDGAYVYHNEHEVGEAIREKIAEGKVKREEIFYCGK 86
Cdd:cd19108 1 QRVKLNDGHFIPVLGFGTYA-PEEVPkSKALEATKLAIDAGFRHIDSAYLYQNEEEVGQAIRSKIADGTVKREDIFYTSK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 87 LWNTEHVPSMVLPALERTLKALKLDYIDLYIIELPMAFKPGKEIYPRDENGRIIYDKTNLCATWEALEACKDAGLVKSLG 166
Cdd:cd19108 80 LWCTFHRPELVRPALEKSLKKLQLDYVDLYLIHFPVALKPGEELFPKDENGKLIFDTVDLCATWEAMEKCKDAGLAKSIG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 167 VSNFNRRQLELILNKPGLKYKPVTNQVECHPYFTQTKLLKFCQQHDIVIVAHSPLGTCRNPSWVNVSSPPLLNDELLTSL 246
Cdd:cd19108 160 VSNFNRRQLEMILNKPGLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAYSALGSQRDKEWVDQNSPVLLEDPVLCAL 239
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568941248 247 GKKYNKTQAQIVLRFNIQRGIVVIPKSFTPERIKENFQIFDFSLTEEEMKDIDALNKNVRYV 308
Cdd:cd19108 240 AKKHKRTPALIALRYQLQRGVVVLAKSFNEKRIKENLQVFEFQLTSEDMKALDGLNRNLRYL 301
|
|
| AKR_AKR1B1-19 |
cd19107 |
AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase ... |
15-325 |
6.55e-151 |
|
AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase (AR, EC 1.1.1.21) from Homo sapiens (AKR1B1), Oryctolagus cuniculus (kidney, AKR1B2), Mus musculus (AKR1B3), Rattus norvegicus (lens, AKR1B4), Bos taurus (lens/testis, AKR1B5), and Sus scrofa (lens, AKR1B6), aldose reductase-related protein 1 (ALD1, EC1.1.1.21) from Mus musculus (AKR1B7), Rattus norvegicus (AKR1B14), and Homo sapiens (AKR1B15), Mus musculus fibroblast growth factor induced protein (FR-1 or AKR1B8, EC 1.1.1.21), Cricetulus griseus aldose reductase-related protein 2 (ALD2 or AKR1B9, EC 1.1.1.21), aldose reductase-like from Homo sapiens (ARL-1 or AKR1B10) and Rattus norvegicus (AKR1B13), aldo-keto reductase from Gallus domesticus (eye, tongue, esophagus, AKR1B12), and Oryctolagus cuniculus AR-like protein (3beta-HSD, AKR1B19). AR, also called aldehyde reductase, catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies. ALD1 reduces a broad range of aliphatic and aromatic aldehydes to the corresponding alcohols. It may play a role in the metabolism of xenobiotic aromatic aldehydes. FR-1, also called aldose reductase-related protein 2, or fibroblast growth factor-regulated protein (FGFRP), is induced by fibroblast growth factor-1. It may play a role in the regulation of the cell cycle. FR-1 belongs to the NADPH-dependent aldo-keto reductase family. ALD2 is an inducible aldo-keto reductase with a preference for aliphatic substrates. It can also act on small aromatic aldehydes, steroid aldehydes and some ketone substrates. ARL-1, also called aldose reductase-like, or aldose reductase-related protein (ARP), or small intestine reductase, or SI reductase, acts as all-trans-retinaldehyde reductase that can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). It may be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs. AKR1B15, also called estradiol 17-beta-dehydrogenase AKR1B15, is a mitochondrial aldo-keto reductase that catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs. It has a strong selectivity towards NADP(H). AKR1B19 is aldose reductase-like that may show 3-beta-hydroxysteroid dehydrogenase (3beta-HSD) activity.
Pssm-ID: 381333 [Multi-domain] Cd Length: 307 Bit Score: 426.06 E-value: 6.55e-151
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 15 GNNIPLIGLGTYSDPrpvPGKTYVAVKTAIDEGYRHIDGAYVYHNEHEVGEAIREKIAEGKVKREEIFYCGKLWNTEHVP 94
Cdd:cd19107 1 GAKMPILGLGTWKSP---PGQVTEAVKVAIDAGYRHIDCAYVYQNENEVGEAIQEKIKEQVVKREDLFIVSKLWCTFHEK 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 95 SMVLPALERTLKALKLDYIDLYIIELPMAFKPGKEIYPRDENGRIIYDKTNLCATWEALEACKDAGLVKSLGVSNFNRRQ 174
Cdd:cd19107 78 GLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKELFPLDESGNVIPSDTTFLDTWEAMEELVDEGLVKAIGVSNFNHLQ 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 175 LELILNKPGLKYKPVTNQVECHPYFTQTKLLKFCQQHDIVIVAHSPLGTCRNPsWVNVSSPPLLNDELLTSLGKKYNKTQ 254
Cdd:cd19107 158 IERILNKPGLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRP-WAKPEDPSLLEDPKIKEIAAKHNKTT 236
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568941248 255 AQIVLRFNIQRGIVVIPKSFTPERIKENFQIFDFSLTEEEMKDIDALNKNVRYVELLMWSDHPEYPFHDEY 325
Cdd:cd19107 237 AQVLIRFPIQRNLVVIPKSVTPERIAENFKVFDFELSSEDMATILSFNRNWRACALLSCSSHKDYPFHAEY 307
|
|
| AKR_AKR1A1-4 |
cd19106 |
AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol ... |
12-308 |
3.92e-141 |
|
AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol dehydrogenase [NADP(+)] (ALR, EC 1.1.1.2) from Homo sapiens (AKR1A1), Sus scrofa (AKR1A2), Rattus norvegicus (liver, AKR1A3), and Mus musculus (AKR1A4). ALR, also known as aldehyde reductase, or ALDR1, catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid.
Pssm-ID: 381332 [Multi-domain] Cd Length: 305 Bit Score: 400.99 E-value: 3.92e-141
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 12 LSDGNNIPLIGLGTYsdpRPVPGKTYVAVKTAIDEGYRHIDGAYVYHNEHEVGEAIREKIAEGK-VKREEIFYCGKLWNT 90
Cdd:cd19106 1 LHTGQKMPLIGLGTW---KSKPGQVKAAVKYALDAGYRHIDCAAVYGNEQEVGEALKEKVGPGKaVPREDLFVTSKLWNT 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 91 EHVPSMVLPALERTLKALKLDYIDLYIIELPMAFKPGKEIYPRDENGRIIYDKTNLCATWEALEACKDAGLVKSLGVSNF 170
Cdd:cd19106 78 KHHPEDVEPALRKTLKDLQLDYLDLYLIHWPYAFERGDNPFPKNPDGTIRYDSTHYKETWKAMEKLVDKGLVKAIGLSNF 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 171 NRRQLELILNKPglKYKPVTNQVECHPYFTQTKLLKFCQQHDIVIVAHSPLGTCRNPsWVNVSSPPLLNDELLTSLGKKY 250
Cdd:cd19106 158 NSRQIDDILSVA--RIKPAVLQVECHPYLAQNELIAHCKARGLVVTAYSPLGSPDRP-WAKPDEPVLLEEPKVKALAKKY 234
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 568941248 251 NKTQAQIVLRFNIQRGIVVIPKSFTPERIKENFQIFDFSLTEEEMKDIDALNKNVRYV 308
Cdd:cd19106 235 NKSPAQILLRWQVQRGVVVIPKSVTPSRIKQNIQVFDFTLSPEEMKQLDALNRNWRYI 292
|
|
| AKR_AKR1E1-2 |
cd19110 |
AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1, ... |
17-325 |
1.82e-130 |
|
AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1,5-anhydro-D-fructose reductase (EC 1.1.1.263) from Mus musculus (liver, AKR1E1) and Homo sapiens (AKR1E2). 1,5-anhydro-D-fructose reductase), also called AF reductase, or aldo-keto reductase family 1 member C-like protein 2 (AKR1CL2), catalyzes the NADPH-dependent reduction of 1,5-anhydro-D-fructose (AF) to 1,5-anhydro-D-glucitol. AKR1E2 is a testis aldo-keto reductase (tAKR), which is also known as testis-specific protein (TSP), or LoopADR.
Pssm-ID: 381336 [Multi-domain] Cd Length: 301 Bit Score: 373.91 E-value: 1.82e-130
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 17 NIPLIGLGTYsdpRPVPGKTYVAVKTAIDEGYRHIDGAYVYHNEHEVGEAIREKIAEGKVKREEIFYCGKLWNTEHVPSM 96
Cdd:cd19110 3 DIPAVGLGTW---KASPGEVTEAVKVAIDAGYRHFDCAYLYHNESEVGAGIREKIKEGVVRREDLFIVSKLWCTCHKKSL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 97 VLPALERTLKALKLDYIDLYIIELPMAFKPGKEIYPRDENGRIIYDKTNLCATWEALEACKDAGLVKSLGVSNFNRRQLE 176
Cdd:cd19110 80 VKTACTRSLKALKLNYLDLYLIHWPMGFKPGEPDLPLDRSGMVIPSDTDFLDTWEAMEDLVIEGLVKNIGVSNFNHEQLE 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 177 LILNKPGLKYKPVTNQVECHPYFTQTKLLKFCQQHDIVIVAHSPLGTcrnpswvNVSSPPLLNDELLTSLGKKYNKTQAQ 256
Cdd:cd19110 160 RLLNKPGLRVKPVTNQIECHPYLTQKKLISFCQSRNVSVTAYRPLGG-------SCEGVDLIDDPVIQRIAKKHGKSPAQ 232
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568941248 257 IVLRFNIQRGIVVIPKSFTPERIKENFQIFDFSLTEEEMKDIDALNKNVRYVELLMWSDHPEYPFHDEY 325
Cdd:cd19110 233 ILIRFQIQRNVIVIPKSVTPSRIKENIQVFDFELTEHDMDNLLSLDRNLRLATFPITENHKDYPFHIEY 301
|
|
| AKR_AKR2E1-5 |
cd19116 |
AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a ... |
10-308 |
3.22e-128 |
|
AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a founding member of aldo-keto reductase family 2 member E4 (AKR2E4). It is a NADP-dependent oxidoreductase with high 3-dehydroecdysone reductase activity. It may play a role in the regulation of molting and has lower activity with phenylglyoxal and isatin (in vitro). This family also includes 3-dehydroecdysone 3b-reductase from Spodoptera littoralis and Trichoplusia ni, DL-glyceraldehyde reductase from Drosophila melanogaster, aldo-keto reductase from Bombyx mori, which correspond to aldo-keto reductase family 2 member E1, E2, E3 and E5 (AKR2E1/2/3/5), respectively.
Pssm-ID: 381342 [Multi-domain] Cd Length: 292 Bit Score: 367.76 E-value: 3.22e-128
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 10 ISLSDGNNIPLIGLGTYSDPRPVPGKTyvAVKTAIDEGYRHIDGAYVYHNEHEVGEAIREKIAEGKVKREEIFYCGKLWN 89
Cdd:cd19116 3 IKLNDGNEIPAIALGTWKLKDDEGVRQ--AVKHAIEAGYRHIDTAYLYGNEAEVGEAIREKIAEGVVKREDLFITTKLWN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 90 TEHVPSMVLPALERTLKALKLDYIDLYIIELPMAFkpgKEIYPRDENGRIIYDKTNLCATWEALEACKDAGLVKSLGVSN 169
Cdd:cd19116 81 SYHEREQVEPALRESLKRLGLDYVDLYLIHWPVAF---KENNDSESNGDGSLSDIDYLETWRGMEDLVKLGLTRSIGVSN 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 170 FNRRQLELILNkpGLKYKPVTNQVECHPYFTQTKLLKFCQQHDIVIVAHSPLGTcRNPSWVNvSSPPLLNDELLTSLGKK 249
Cdd:cd19116 158 FNSEQINRLLS--NCNIKPAVNQIEVHPTLTQEKLVAYCQSNGIVVMAYSPFGR-LVPRGQT-NPPPRLDDPTLVAIAKK 233
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 568941248 250 YNKTQAQIVLRFNIQRGIVVIPKSFTPERIKENFQIFDFSLTEEEMKDIDALNKNVRYV 308
Cdd:cd19116 234 YGKTTAQIVLRYLIDRGVVPIPKSSNKKRIKENIDIFDFQLTPEEVAALNSFNTNQRVY 292
|
|
| AKR_AKR1-5-like |
cd19071 |
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases ... |
18-299 |
2.31e-126 |
|
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. The family includes AKR1A/B/C/D/E/G/I, AKR2A/B/C/D/E, AKR3A/B/C/D/E/G, AKR4A/B/C, AKR5A/B/C/D/E/F/G/H, and similar proteins.
Pssm-ID: 381297 [Multi-domain] Cd Length: 251 Bit Score: 361.41 E-value: 2.31e-126
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 18 IPLIGLGTYSDPrpvPGKTYVAVKTAIDEGYRHIDGAYVYHNEHEVGEAIREKIaegkVKREEIFYCGKLWNTEHVPSMV 97
Cdd:cd19071 1 MPLIGLGTYKLK---PEETAEAVLAALEAGYRHIDTAAAYGNEAEVGEAIRESG----VPREELFITTKLWPTDHGYERV 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 98 LPALERTLKALKLDYIDLYIIELPMAFKPGKeiyprdengriiyDKTNLCATWEALEACKDAGLVKSLGVSNFNRRQLEL 177
Cdd:cd19071 74 REALEESLKDLGLDYLDLYLIHWPVPGKEGG-------------SKEARLETWRALEELVDEGLVRSIGVSNFNVEHLEE 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 178 ILNKPglKYKPVTNQVECHPYFTQTKLLKFCQQHDIVIVAHSPLGTCRNPswvnvssppLLNDELLTSLGKKYNKTQAQI 257
Cdd:cd19071 141 LLAAA--RIKPAVNQIELHPYLQQKELVEFCKEHGIVVQAYSPLGRGRRP---------LLDDPVLKEIAKKYGKTPAQV 209
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 568941248 258 VLRFNIQRGIVVIPKSFTPERIKENFQIFDFSLTEEEMKDID 299
Cdd:cd19071 210 LLRWALQRGVVVIPKSSNPERIKENLDVFDFELSEEDMAAID 251
|
|
| AKR_AKR1G1_CeAKR |
cd19154 |
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding ... |
10-306 |
1.14e-119 |
|
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381380 [Multi-domain] Cd Length: 303 Bit Score: 346.71 E-value: 1.14e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 10 ISLSDGNNIPLIGLGTYsDPRPVPGKTyvAVKTAIDEGYRHIDGAYVYHNEHEVGEAIREKIAEGKVKREEIFYCGKLWN 89
Cdd:cd19154 4 ITLSNGVKMPLIGLGTW-QSKGAEGIT--AVRTALKAGYRLIDTAFLYQNEEAIGEALAELLEEGVVKREDLFITTKLWT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 90 TEHVPSMVLPALERTLKALKLDYIDLYIIELPMAFKPGKEIYPRDENGRIIYDKTNLCATWEALEACKDAGLVKSLGVSN 169
Cdd:cd19154 81 HEHAPEDVEEALRESLKKLQLEYVDLYLIHAPAAFKDDEGESGTMENGMSIHDAVDVEDVWRGMEKVYDEGLTKAIGVSN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 170 FNRRQLELILNKPglKYKPVTNQVECHPYFTQTKLLKFCQQHDIVIVAHSPLGTC--RNPSWVNVSSPP--LLNDELLTS 245
Cdd:cd19154 161 FNNDQIQRILDNA--RVKPHNNQVECHLYFPQKELVEFCKKHNISVTSYATLGSPgrANFTKSTGVSPApnLLQDPIVKA 238
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568941248 246 LGKKYNKTQAQIVLRFNIQRGIVVIPKSFTPERIKENFQIFDFSLTEEEMKDIDALNKNVR 306
Cdd:cd19154 239 IAEKHGKTPAQVLLRYLLQRGIAVIPKSATPSRIKENFNIFDFSLSEEDMATLEEIEKSLR 299
|
|
| ARA1 |
COG0656 |
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, ... |
14-307 |
2.81e-118 |
|
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism];
Pssm-ID: 440421 [Multi-domain] Cd Length: 259 Bit Score: 341.26 E-value: 2.81e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 14 DGNNIPLIGLGTYsdpRPVPGKTYVAVKTAIDEGYRHIDGAYVYHNEHEVGEAIREkiaeGKVKREEIFYCGKLWNTEHV 93
Cdd:COG0656 1 NGVEIPALGLGTW---QLPGEEAAAAVRTALEAGYRHIDTAAMYGNEEGVGEAIAA----SGVPREELFVTTKVWNDNHG 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 94 PSMVLPALERTLKALKLDYIDLYIIELPMafkPGKeiyprdengriiydktnLCATWEALEACKDAGLVKSLGVSNFNRR 173
Cdd:COG0656 74 YDDTLAAFEESLERLGLDYLDLYLIHWPG---PGP-----------------YVETWRALEELYEEGLIRAIGVSNFDPE 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 174 QLELILNKPGlkYKPVTNQVECHPYFTQTKLLKFCQQHDIVIVAHSPLGtcrnpswvnvsSPPLLNDELLTSLGKKYNKT 253
Cdd:COG0656 134 HLEELLAETG--VKPAVNQVELHPYLQQRELLAFCREHGIVVEAYSPLG-----------RGKLLDDPVLAEIAEKHGKT 200
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 568941248 254 QAQIVLRFNIQRGIVVIPKSFTPERIKENFQIFDFSLTEEEMKDIDALNKNVRY 307
Cdd:COG0656 201 PAQVVLRWHLQRGVVVIPKSVTPERIRENLDAFDFELSDEDMAAIDALDRGERL 254
|
|
| AKR_AKR3G1 |
cd19123 |
AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a ... |
9-308 |
2.77e-111 |
|
AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a founding member of aldo-keto reductase family 3 member G1 (AKR3G1). It is an aldo/keto reductase that catalyzes the NADPH-dependent reduction of aldehyde- and ketone-groups of different classes of carbonyl compounds to the corresponding alcohols.
Pssm-ID: 381349 [Multi-domain] Cd Length: 297 Bit Score: 325.13 E-value: 2.77e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 9 QISLSDGNNIPLIGLGTYsdpRPVPGKTYVAVKTAIDEGYRHIDGAYVYHNEHEVGEAIREKIAEGKVKREEIFYCGKLW 88
Cdd:cd19123 3 TLPLSNGDLIPALGLGTW---KSKPGEVGQAVKQALEAGYRHIDCAAIYGNEAEIGAALAEVFKEGKVKREDLWITSKLW 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 89 NTEHVPSMVLPALERTLKALKLDYIDLYIIELPMAFKPGKeIYPRDENGRIIYDKTNLCATWEALEACKDAGLVKSLGVS 168
Cdd:cd19123 80 NNSHAPEDVLPALEKTLADLQLDYLDLYLMHWPVALKKGV-GFPESGEDLLSLSPIPLEDTWRAMEELVDKGLCRHIGVS 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 169 NFNRRQLELILNKPglKYKPVTNQVECHPYFTQTKLLKFCQQHDIVIVAHSPLGTCRNPSWVNVSSPP-LLNDELLTSLG 247
Cdd:cd19123 159 NFSVKKLEDLLATA--RIKPAVNQVELHPYLQQPELLAFCRDNGIHLTAYSPLGSGDRPAAMKAEGEPvLLEDPVINKIA 236
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568941248 248 KKYNKTQAQIVLRFNIQRGIVVIPKSFTPERIKENFQIFDFSLTEEEMKDIDALNKNVRYV 308
Cdd:cd19123 237 EKHGASPAQVLIAWAIQRGTVVIPKSVNPERIQQNLEAAEVELDASDMATIAALDRHHRYV 297
|
|
| AKR_AKR4C1-15 |
cd19125 |
AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase ... |
12-299 |
1.95e-107 |
|
AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase (ALR) from Hordeum vulgare (AKR4C1), Bromus inermis (AKR4C2), Avena fatua (AKR4C3), and Xerophyta viscosa (AKR4C4), two aldose reductases, DpAR1 (AKR4C5) and DpAR2(AKR4C6), from Digitalis purpurea, aldehyde reductase from Zea mays (AKR4C7), four aldo-keto reductases from Arabidopsis thaliana (AKR4C8-11), and another three aldo-keto reductases from Aloe arborescens (AKR4C12) and Oryza sativa (AKR4C14/15). ALR (EC 1.1.1.21), also called AR, aldehyde reductase, or polyol dehydrogenase (NADP(+)), is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides. Both DpAR1 and DpAR2 reduce the ketone group of steroid structures. They may be involved in plant steroid metabolism in general and in cardenolide biosynthesis in particular. Plant aldo-keto reductases of the AKR4C subfamily play key roles during stress and are attractive targets for developing stress-tolerant crops.
Pssm-ID: 381351 [Multi-domain] Cd Length: 287 Bit Score: 314.67 E-value: 1.95e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 12 LSDGNNIPLIGLGTYsdpRPVPGKTYVAVKTAIDEGYRHIDGAYVYHNEHEVGEAIREKIAEGKVKREEIFYCGKLWNTE 91
Cdd:cd19125 5 LNTGAKIPAVGLGTW---QADPGVVGNAVKTAIKEGYRHIDCAAIYGNEKEIGKALKKLFEDGVVKREDLFITSKLWCTD 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 92 HVPSMVLPALERTLKALKLDYIDLYIIELPMAFKPGKEIYPRDEngriiYDKTNLCATWEALEACKDAGLVKSLGVSNFN 171
Cdd:cd19125 82 HAPEDVPPALEKTLKDLQLDYLDLYLIHWPVRLKKGAHMPEPEE-----VLPPDIPSTWKAMEKLVDSGKVRAIGVSNFS 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 172 RRQLELILNKPglKYKPVTNQVECHPYFTQTKLLKFCQQHDIVIVAHSPLGTcRNPSWVNvssPPLLNDELLTSLGKKYN 251
Cdd:cd19125 157 VKKLEDLLAVA--RVPPAVNQVECHPGWQQDKLHEFCKSKGIHLSAYSPLGS-PGTTWVK---KNVLKDPIVTKVAEKLG 230
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 568941248 252 KTQAQIVLRFNIQRGIVVIPKSFTPERIKENFQIFDFSLTEEEMKDID 299
Cdd:cd19125 231 KTPAQVALRWGLQRGTSVLPKSTNEERIKENIDVFDWSIPEEDFAKFS 278
|
|
| AKR_AKR1G1_1I |
cd19111 |
Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase ... |
15-307 |
4.99e-98 |
|
Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.
Pssm-ID: 381337 [Multi-domain] Cd Length: 286 Bit Score: 290.94 E-value: 4.99e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 15 GNNIPLIGLGTYSDPrpvPGKTYVAVKTAIDEGYRHIDGAYVYHNEHEVGEAIREKIAEGKVKREEIFYCGKLWNTEHVP 94
Cdd:cd19111 1 GFPMPVIGLGTYQSP---PEEVRAAVDYALFVGYRHIDTALSYQNEKAIGEALKWWLKNGKLKREEVFITTKLPPVYLEF 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 95 SMVLPALERTLKALKLDYIDLYIIELPMAFKpgkeiyPRDENGRIIYDKTNLCATWEALEACKDAGLVKSLGVSNFNRRQ 174
Cdd:cd19111 78 KDTEKSLEKSLENLKLPYVDLYLIHHPCGFV------NKKDKGERELASSDVTSVWRAMEALVSEGKVKSIGLSNFNPRQ 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 175 LELILNKPglKYKPVTNQVECHPYFTQTKLLKFCQQHDIVIVAHSPLGTcrnPSWVNVSSPP----LLNDELLTSLGKKY 250
Cdd:cd19111 152 INKILAYA--KVKPSNLQLECHAYLQQRELRKFCNKKNIVVTAYAPLGS---PGRANQSLWPdqpdLLEDPTVLAIAKEL 226
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 568941248 251 NKTQAQIVLRFNIQRGIVVIPKSFTPERIKENFQIFDFSLTEEEMKDIDALNKNVRY 307
Cdd:cd19111 227 DKTPAQVLLRFVLQRGTGVLPKSTNKERIEENFEVFDFELTEEHFKKLKTLDRNMKY 283
|
|
| AKR_AKR2A1-2 |
cd19112 |
AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 ... |
10-307 |
9.58e-97 |
|
AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 (NADP-dependent D-sorbitol-6-phosphate dehydrogenase or NADP-S6PDH) from Malus domestica, and AKR2A2 (NADPH-dependent mannose-6-phosphate reductase or NADPH-M6PR) from Apium graveolens. NADP-S6PDH (EC 1.1.1.200), also called aldose-6-phosphate reductase [NADPH], synthesizes sorbitol-6-phosphate, a key intermediate in the synthesis of sorbitol which is a major photosynthetic product in many members of the Rosaceae family. NADPH-M6PR (EC 1.1.1.224), also called NADPH-dependent M6P reductase, is a key enzyme involved in mannitol biosynthesis.
Pssm-ID: 381338 [Multi-domain] Cd Length: 308 Bit Score: 288.62 E-value: 9.58e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 10 ISLSDGNNIPLIGLGTYsdpRPVPGKTYVAVKTAIDEGYRHIDGAYVYHNEHEVGEAIREKIAEGKVKREEIFYCGKLWN 89
Cdd:cd19112 3 ITLNSGHKMPVIGLGVW---RMEPGEIKELILNAIKIGYRHFDCAADYKNEKEVGEALAEAFKTGLVKREDLFITTKLWN 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 90 TEHvpSMVLPALERTLKALKLDYIDLYIIELPMAFKP---GKEIYPRDENGRIIYDKT-NLCATWEALEACKDAGLVKSL 165
Cdd:cd19112 80 SDH--GHVIEACKDSLKKLQLDYLDLYLVHFPVATKHtgvGTTGSALGEDGVLDIDVTiSLETTWHAMEKLVSAGLVRSI 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 166 GVSNFnrrqlELILNKPGLKY---KPVTNQVECHPYFTQTKLLKFCQQHDIVIVAHSPLG-TCRNPSWVNVSSPplLNDE 241
Cdd:cd19112 158 GISNY-----DIFLTRDCLAYskiKPAVNQIETHPYFQRDSLVKFCQKHGISVTAHTPLGgAAANAEWFGSVSP--LDDP 230
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568941248 242 LLTSLGKKYNKTQAQIVLRFNIQRGIVVIPKSFTPERIKENFQIFDFSLTEEEMKDIDALNKNVRY 307
Cdd:cd19112 231 VLKDLAKKYGKSAAQIVLRWGIQRNTAVIPKSSKPERLKENIDVFDFQLSKEDMKLIKSLDRKYRT 296
|
|
| AKR_AKR3B1-3 |
cd19118 |
AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde ... |
12-301 |
3.67e-96 |
|
AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde reductase 1 (ARI, EC 1.1.1.2), Trichosporonoides megachilieni NADPH-dependent erthyrose reductase (ER) 1/2 and 3, are founding members of aldo-keto reductase family 3 member B1 (AKR3B1), B2 (AKR3B2), and B3 (AKR3B3), respectively. Sporidiobolus salmonicolor NADPH-ARI, also called alcohol dehydrogenase [NADP(+)], or aldehyde reductase I, or ALR 1, catalyzes the asymmetric reduction of aliphatic and aromatic aldehydes and ketones to an R-enantiomer. It reduces ethyl 4-chloro-3-oxobutanoate to ethyl (R)-4-chloro-3-hydroxybutanoate. Trichosporonoides megachilieni NADPH-ERs catalyze the reduction of D-erythrose.
Pssm-ID: 381344 [Multi-domain] Cd Length: 283 Bit Score: 285.84 E-value: 3.67e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 12 LSDGNNIPLIGLGTYsdpRPVPGKTYVAVKTAIDEGYRHIDGAYVYHNEHEVGEAIREKIAE-GKVKREEIFYCGKLWNT 90
Cdd:cd19118 1 LNTGNKIPAIGLGTW---QAEPGEVGAAVKIALKAGYRHLDLAKVYQNQHEVGQALKELLKEePGVKREDLFITSKLWNN 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 91 EHVPSMVLPALERTLKALKLDYIDLYIIELPMAFKPGKEIYPR-----DENGRIIYDKTNLCATWEALEACKDAGLVKSL 165
Cdd:cd19118 78 SHRPEYVEPALDDTLKELGLDYLDLYLIHWPVAFKPTGDLNPLtavptNGGEVDLDLSVSLVDTWKAMVELKKTGKVKSI 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 166 GVSNFNRRQLELILNKPGLkyKPVTNQVECHPYFTQTKLLKFCQQHDIVIVAHSPLGTCRnpswvnVSSPPLLNDELLTS 245
Cdd:cd19118 158 GVSNFSIDHLQAIIEETGV--VPAVNQIEAHPLLLQDELVDYCKSKNIHITAYSPLGNNL------AGLPLLVQHPEVKA 229
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 568941248 246 LGKKYNKTQAQIVLRFNIQRGIVVIPKSFTPERIKENFQifDFSLTEEEMKDIDAL 301
Cdd:cd19118 230 IAAKLGKTPAQVLIAWGIQRGHSVIPKSVTPSRIRSNFE--QVELSDDEFNAVTAL 283
|
|
| AKR_AKR4A_4B |
cd19124 |
AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes ... |
14-301 |
5.43e-94 |
|
AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes Glycine max NAD(P)H-dependent 6'-deoxychalcone synthase (6DCS, EC 3.1.170), chalcone reductase (CHR, EC 2.3.1.74) from Medicago sativa, Glycyrrhiza echinate, and Glycyrrhiza glabra, which are founding members of aldo-keto reductase family 4 member A1 (AKR4A1), A2 (AKR4A2), A3 (AKR4A3), and A4 (AKR4A4), respectively. NAD(P)H-6DCS co-acts with chalcone synthase in formation of 4,2',4'-trihydroxychalcone, involved in the biosynthesis of glyceollin type phytoalexins. CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. The AKR4B family of AKR includes Sesbania rostrate chalcone reductase (CHR, AKR4B1), Papaver somniferum codeinone reductase (COR, AKR4B2/ AKR4B3), Fragaria x ananassa D-galacturonate reductase (GalUR, AKR4B4), deoxymugineic acid synthase 1 (DMAS1) from Zea mays (AKR4B5), Oryza sativa (AKR4B6), Hordeum vulgare (AKR4B7), Triticum aestivum (AKR4B8), and Erythroxylum coca methylecgonone reductase (MecgoR, AKR4B10). CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. NADPH-dependent COR and non-functional NADPH-dependent COR from Papaver somniferum are founding members of aldo-keto reductase family 4 member B2 (AKR4B2) and B3 (AKR4B3), respectively. NADPH-dependent COR (EC 1.1.1.247) reduces codeinone to codeine in the penultimate step in morphine biosynthesis. It can use morphinone, hydrocodone, and hydromorphone as substrates during reductive reaction with NADPH as cofactor, and morphine and dihydrocodeine as substrates during oxidative reaction with NADP as cofactor. GalUR (EC 1.1.1.365), also called aldo-keto reductase 2 (AKR2), is involved in ascorbic acid (vitamin C) biosynthesis by catalyzing the conversion from L-galactonate and NADP(+) to D-galacturonate and NADPH. DMAS1 (EC 1.1.1.285) catalyzes the reduction of a 3''-keto intermediate during the biosynthesis of 2'-deoxymugineic acid (DMA) from L-Met. It is involved in the formation of phytosiderophores (MAs) belonging to the mugineic acid family and required to acquire iron. MecgoR catalyzes the stereospecific reduction of methylecgonone to methylecgonine, the penultimate step in cocaine biosynthesis.
Pssm-ID: 381350 [Multi-domain] Cd Length: 281 Bit Score: 280.31 E-value: 5.43e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 14 DGNNIPLIGLGTYSDPrPVPGKTYVAVKTAIDEGYRHIDGAYVYHNEHEVGEAIREKIAEGKVK-REEIFYCGKLWNTEH 92
Cdd:cd19124 1 SGQTMPVIGMGTASDP-PSPEDIKAAVLEAIEVGYRHFDTAAAYGTEEALGEALAEALRLGLVKsRDELFVTSKLWCSDA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 93 VPSMVLPALERTLKALKLDYIDLYIIELPMAFKPGKEIYPRDENGRIIYDktnLCATWEALEACKDAGLVKSLGVSNFNR 172
Cdd:cd19124 80 HPDLVLPALKKSLRNLQLEYVDLYLIHWPVSLKPGKFSFPIEEEDFLPFD---IKGVWEAMEECQRLGLTKAIGVSNFSC 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 173 RQLELILNKPglKYKPVTNQVECHPYFTQTKLLKFCQQHDIVIVAHSPLGTCRNPsWvnvSSPPLLNDELLTSLGKKYNK 252
Cdd:cd19124 157 KKLQELLSFA--TIPPAVNQVEMNPAWQQKKLREFCKANGIHVTAYSPLGAPGTK-W---GSNAVMESDVLKEIAAAKGK 230
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 568941248 253 TQAQIVLRFNIQRGIVVIPKSFTPERIKENFQIFDFSLTEEEMKDIDAL 301
Cdd:cd19124 231 TVAQVSLRWVYEQGVSLVVKSFNKERMKQNLDIFDWELTEEDLEKISEI 279
|
|
| AKR_AKR1I_CgAKR1 |
cd19155 |
Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi ... |
10-306 |
1.34e-93 |
|
Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.
Pssm-ID: 381381 [Multi-domain] Cd Length: 307 Bit Score: 280.57 E-value: 1.34e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 10 ISLSDGNNIPLIGLGTYSDPrpvPGKTYVAVKTAIDEGYRHIDGAYVYHNEHEVGEAIREKIAEGKVKREEIFYCGKLWN 89
Cdd:cd19155 4 VTFNNGEKMPVVGLGTWQSS---PEEIETAVDTALEAGYRHIDTAYVYRNEAAIGNVLKKWIDSGKVKREELFIVTKLPP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 90 TEHVPSMVLPALERTLKALKLDYIDLYIIELPMAFKpGKEI--YPRDENGRIIYD-KTNLCATWEALEACKDAGLVKSLG 166
Cdd:cd19155 81 GGNRREKVEKFLLKSLEKLQLDYVDLYLIHFPVGSL-SKEDdsGKLDPTGEHKQDyTTDLLDIWKAMEAQVDQGLTRSIG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 167 VSNFNRRQLELILNKPglKYKPVTNQVECHPYFTQTKLLKFCQQHDIVIVAHSPLGTcrnPSWVNV---------SSPPL 237
Cdd:cd19155 160 LSNFNREQMARILKNA--RIKPANLQVELHVYLQQKDLVDFCSTHSITVTAYAPLGS---PGAAHFspgtgspsgSSPDL 234
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568941248 238 LNDELLTSLGKKYNKTQAQIVLRFNIQRGIVVIPKSFTPERIKENFQIFDFSLTEEEMKDIDALNKNVR 306
Cdd:cd19155 235 LQDPVVKAIAERHGKSPAQVLLRWLMQRGVVVIPKSTNAARIKENFQVFDFELTEADMAKLSSLDKNIR 303
|
|
| AKR_AKR5C2 |
cd19131 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; ... |
9-302 |
6.76e-91 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; Escherichia coli DkgA/YqhE is a founding member of aldo-keto reductase family 5 member C2 (AKR5C2). DkgA/YqhE (EC 1.1.1.274), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). It is also capable of stereoselective -keto ester reductions on ethyl acetoacetate and other 2-substituted derivatives.
Pssm-ID: 381357 [Multi-domain] Cd Length: 256 Bit Score: 271.55 E-value: 6.76e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 9 QISLSDGNNIPLIGLGTYSDPrpvPGKTYVAVKTAIDEGYRHIDGAYVYHNEHEVGEAIREkiaeGKVKREEIFYCGKLW 88
Cdd:cd19131 1 TITLNDGNTIPQLGLGVWQVS---NDEAASAVREALEVGYRSIDTAAIYGNEEGVGKAIRA----SGVPREELFITTKLW 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 89 NTEHVPSMVLPALERTLKALKLDYIDLYIIELPMafkPGKEIYprdengriiydktnlCATWEALEACKDAGLVKSLGVS 168
Cdd:cd19131 74 NSDQGYDSTLRAFDESLRKLGLDYVDLYLIHWPV---PAQDKY---------------VETWKALIELKKEGRVKSIGVS 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 169 NFNRRQLELILNKPGLKykPVTNQVECHPYFTQTKLLKFCQQHDIVIVAHSPLGTCRnpswvnvssppLLNDELLTSLGK 248
Cdd:cd19131 136 NFTIEHLQRLIDETGVV--PVVNQIELHPRFQQRELRAFHAKHGIQTESWSPLGQGG-----------LLSDPVIGEIAE 202
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 568941248 249 KYNKTQAQIVLRFNIQRGIVVIPKSFTPERIKENFQIFDFSLTEEEMKDIDALN 302
Cdd:cd19131 203 KHGKTPAQVVIRWHLQNGLVVIPKSVTPSRIAENFDVFDFELDADDMQAIAGLD 256
|
|
| AKR_AKR5F1 |
cd19133 |
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid ... |
10-302 |
7.11e-91 |
|
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid reductase (2,5-DKG reductase) is a founding member of aldo-keto reductase family 5 member F1 (AKR5F1). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381359 [Multi-domain] Cd Length: 255 Bit Score: 271.37 E-value: 7.11e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 10 ISLSDGNNIPLIGLGTYSdpRPVPGKTYVAVKTAIDEGYRHIDGAYVYHNEHEVGEAIREKiaegKVKREEIFYCGKLW- 88
Cdd:cd19133 1 VTLNNGVEMPILGFGVFQ--IPDPEECERAVLEAIKAGYRLIDTAAAYGNEEAVGRAIKKS----GIPREELFITTKLWi 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 89 -NTEHVPSMvlPALERTLKALKLDYIDLYIIELPMAfkpgkeiyprdengriiydktNLCATWEALEACKDAGLVKSLGV 167
Cdd:cd19133 75 qDAGYEKAK--KAFERSLKRLGLDYLDLYLIHQPFG---------------------DVYGAWRAMEELYKEGKIRAIGV 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 168 SNFNRRQL-ELILNKpglKYKPVTNQVECHPYFTQTKLLKFCQQHDIVIVAHSPLGTCRNPswvnvssppLLNDELLTSL 246
Cdd:cd19133 132 SNFYPDRLvDLILHN---EVKPAVNQIETHPFNQQIEAVEFLKKYGVQIEAWGPFAEGRNN---------LFENPVLTEI 199
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 568941248 247 GKKYNKTQAQIVLRFNIQRGIVVIPKSFTPERIKENFQIFDFSLTEEEMKDIDALN 302
Cdd:cd19133 200 AEKYGKSVAQVILRWLIQRGIVVIPKSVRPERIAENFDIFDFELSDEDMEAIAALD 255
|
|
| AKR_BaDH-like |
cd19129 |
Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium ... |
13-307 |
1.05e-90 |
|
Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium diazoefficiens DH is the prototype of this family. It belongs to aldo/keto reductase family.
Pssm-ID: 381355 [Multi-domain] Cd Length: 295 Bit Score: 272.41 E-value: 1.05e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 13 SDGNNIPLIGLGTYSdprPVPGKTYVAVKTAIDEGYRHIDGAYVYHNEHEVGEAIREKIAEGKVKREEIFYCGKLWNTEH 92
Cdd:cd19129 1 NGSGAIPALGFGTLI---PDPSATRNAVKAALEAGFRHFDCAERYRNEAEVGEAMQEVFKAGKIRREDLFVTTKLWNTNH 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 93 VPSMVLPALERTLKALKLDYIDLYIIELPMAFKPGKEIYPRDENGRIIYDK-TNLCATWEALEACKDAGLVKSLGVSNFN 171
Cdd:cd19129 78 RPERVKPAFEASLKRLQLDYLDLYLIHTPFAFQPGDEQDPRDANGNVIYDDgVTLLDTWRAMERLVDEGRCKAIGLSDVS 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 172 RRQLELILNKPglKYKPVTNQVECHPYFTQTKLLKFCQQHDIVIVAHSPLGtcrnpswvNVSSPPLLNDELLTSLGKKYN 251
Cdd:cd19129 158 LEKLREIFEAA--RIKPAVVQVESHPYLPEWELLDFCKNHGIVLQAFAPLG--------HGMEPKLLEDPVITAIARRVN 227
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 568941248 252 KTQAQIVLRFNIQRGIVVIPKSFTPERIKENFQIfdFSLTEEEMKDI-DALNKNVRY 307
Cdd:cd19129 228 KTPAQVLLAWAIQRGTALLTTSKTPSRIRENFDI--STLPEDAMREInEGIKTRYRF 282
|
|
| AKR_AKR3A1-2 |
cd19117 |
AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are ... |
11-303 |
2.17e-89 |
|
AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are founding members of aldo-keto reductase family 3 member A1 (AKR3A1) and A2 (AKR3A2), respectively. Gcy1p, also called galactose-inducible crystallin-like protein 1, is a glycerol dehydrogenase involved in glycerol catabolism under microaerobic conditions. It has mRNA binding activity. Ypr1p acts as a 2-methylbutyraldehyde reductase that displays high specific activity towards 2-methylbutyraldehyde, as well as other aldehydes such as hexanal.
Pssm-ID: 381343 [Multi-domain] Cd Length: 284 Bit Score: 268.98 E-value: 2.17e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 11 SLSDGNNIPLIGLGTYsdpRPVPGKTYVAVKTAIDEGYRHIDGAYVYHNEHEVGEAIRekiAEGkVKREEIFYCGKLWNT 90
Cdd:cd19117 7 KLNTGAEIPAVGLGTW---QSKPNEVAKAVEAALKAGYRHIDTAAIYGNEEEVGQGIK---DSG-VPREEIFITTKLWCT 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 91 EHvpSMVLPALERTLKALKLDYIDLYIIELPMAFKPG--KEIYPRDENGRIIYDKTNLCATWEALEACKDAGLVKSLGVS 168
Cdd:cd19117 80 WH--RRVEEALDQSLKKLGLDYVDLYLMHWPVPLDPDgnDFLFKKDDGTKDHEPDWDFIKTWELMQKLPATGKVKAIGVS 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 169 NFNRRQLELILNKPGLKYKPVTNQVECHPYFTQTKLLKFCQQHDIVIVAHSPLGTcrnpswvnvSSPPLLNDELLTSLGK 248
Cdd:cd19117 158 NFSIKNLEKLLASPSAKIVPAVNQIELHPLLPQPKLVDFCKSKGIHATAYSPLGS---------TNAPLLKEPVIIKIAK 228
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 568941248 249 KYNKTQAQIVLRFNIQRGIVVIPKSFTPERIKENFQIfdFSLTEEEMKDIDALNK 303
Cdd:cd19117 229 KHGKTPAQVIISWGLQRGYSVLPKSVTPSRIESNFKL--FTLSDEEFKEIDELHK 281
|
|
| AKR_AKR2B1-10 |
cd19113 |
AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent ... |
10-313 |
1.23e-87 |
|
AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent D-xylose reductase (XR) from Pichia stipites, Kluyveromyces lactis, Pachysolen tannophilus, Candida tropicalis, and Candida tenuis, Gre3p from Saccharomyces cerevisiae, XR from Candida tropicalis, Pichia guilliermondii, Debaryomyces hansenli, and Debaryomyces nepalensis, which correspond to aldo-keto reductase family 2 member B1-B10 (AKR2B1-10), respectively. XR (EC1.1.1.307) catalyzes the NAD(P)H dependent reduction of xylose to xylitol.
Pssm-ID: 381339 [Multi-domain] Cd Length: 310 Bit Score: 265.46 E-value: 1.23e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 10 ISLSDGNNIPLIGLGTYSDPRPVPGKTyvaVKTAIDEGYRHIDGAYVYHNEHEVGEAIREKIAEGKVKREEIFYCGKLWN 89
Cdd:cd19113 3 IKLNSGYKMPSVGFGCWKLDNATAADQ---IYQAIKAGYRLFDGAEDYGNEKEVGEGVNRAIDEGLVKREELFLTSKLWN 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 90 TEHVPSMVLPALERTLKALKLDYIDLYIIELPMAFK--PGKEIYPRD----ENGRIIYDKTNLCATWEALEACKDAGLVK 163
Cdd:cd19113 80 NFHDPKNVETALNKTLSDLKLDYVDLFLIHFPIAFKfvPIEEKYPPGfycgDGDNFVYEDVPILDTWKALEKLVDAGKIK 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 164 SLGVSNFNRRQLELILNkpGLKYKPVTNQVECHPYFTQTKLLKFCQQHDIVIVAHSPLGTcrnPSWVNV------SSPPL 237
Cdd:cd19113 160 SIGVSNFPGALILDLLR--GATIKPAVLQIEHHPYLQQPKLIEYAQKAGITITAYSSFGP---QSFVELnqgralNTPTL 234
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568941248 238 LNDELLTSLGKKYNKTQAQIVLRFNIQRGIVVIPKSFTPERIKENFQIFDFSLTEEEMKDIDALNKNVRYVELLMW 313
Cdd:cd19113 235 FEHDTIKSIAAKHNKTPAQVLLRWATQRGIAVIPKSNLPERLLQNLSVNDFDLTKEDFEEIAKLDIGLRFNDPWDW 310
|
|
| AKR_AKR5G1-3 |
cd19157 |
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), ... |
10-307 |
8.42e-86 |
|
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase are founding members of aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.
Pssm-ID: 381383 [Multi-domain] Cd Length: 265 Bit Score: 258.86 E-value: 8.42e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 10 ISLSDGNNIPLIGLGTYSDPRpvpGKTYV-AVKTAIDEGYRHIDGAYVYHNEHEVGEAIREkiaeGKVKREEIFYCGKLW 88
Cdd:cd19157 2 VTLNNGVKMPWLGLGVFKVEE---GSEVVnAVKTALKNGYRSIDTAAIYGNEEGVGKGIKE----SGIPREELFITSKVW 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 89 NTEHVPSMVLPALERTLKALKLDYIDLYIIELPmafkpGKEIYPRdengriiydktnlcaTWEALEACKDAGLVKSLGVS 168
Cdd:cd19157 75 NADQGYDSTLKAFEASLERLGLDYLDLYLIHWP-----VKGKYKE---------------TWKALEKLYKDGRVRAIGVS 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 169 NFNRRQLELILNKPglKYKPVTNQVECHPYFTQTKLLKFCQQHDIVIVAHSPLGTCRnpswvnvssppLLNDELLTSLGK 248
Cdd:cd19157 135 NFQVHHLEDLLADA--EIVPMVNQVEFHPRLTQKELRDYCKKQGIQLEAWSPLMQGQ-----------LLDNPVLKEIAE 201
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 568941248 249 KYNKTQAQIVLRFNIQRGIVVIPKSFTPERIKENFQIFDFSLTEEEMKDIDALNKNVRY 307
Cdd:cd19157 202 KYNKSVAQVILRWDLQNGVVTIPKSIKEHRIIENADVFDFELSQEDMDKIDALNENLRV 260
|
|
| AKR_AKR3F2_3 |
cd19073 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti ... |
18-299 |
2.37e-85 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti isatin reductase and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381299 [Multi-domain] Cd Length: 243 Bit Score: 257.20 E-value: 2.37e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 18 IPLIGLGTYsdpRPVPGKTYVAVKTAIDEGYRHIDGAYVYHNEHEVGEAIrekiAEGKVKREEIFYCGKLWNTEHVPSMV 97
Cdd:cd19073 1 IPALGLGTW---QLRGDDCANAVKEALELGYRHIDTAEIYNNEAEVGEAI----AESGVPREDLFITTKVWRDHLRPEDL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 98 LPALERTLKALKLDYIDLYIIELPmafkpGKEIYPRDengriiydktnlcaTWEALEACKDAGLVKSLGVSNFNRRQLEL 177
Cdd:cd19073 74 KKSVDRSLEKLGTDYVDLLLIHWP-----NPTVPLEE--------------TLGALKELKEAGKVKSIGVSNFTIELLEE 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 178 ILNKPGLKykPVTNQVECHPYFTQTKLLKFCQQHDIVIVAHSPLG-TCrnpswvnvssppLLNDELLTSLGKKYNKTQAQ 256
Cdd:cd19073 135 ALDISPLP--IAVNQVEFHPFLYQAELLEYCRENDIVITAYSPLArGE------------VLRDPVIQEIAEKYDKTPAQ 200
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 568941248 257 IVLRFNIQRGIVVIPKSFTPERIKENFQIFDFSLTEEEMKDID 299
Cdd:cd19073 201 VALRWLVQKGIVVIPKASSEDHLKENLAIFDWELTSEDVAKID 243
|
|
| AKR_DrGR-like |
cd19136 |
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like ... |
18-301 |
3.21e-85 |
|
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like protein is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase similar to Bacillus subtilis glyoxal reductase (YvgN) that reduces glyoxal and methylglyoxal (2-oxopropanal).
Pssm-ID: 381362 [Multi-domain] Cd Length: 262 Bit Score: 257.17 E-value: 3.21e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 18 IPLIGLGTYSdprpVPGK--TYVAVKTAIDEGYRHIDGAYVYHNEHEVGEAIREKIAEGKVKREEIFYCGKLWNTEHVPS 95
Cdd:cd19136 1 MPILGLGTFR----LRGEeeVRQAVDAALKAGYRLIDTASVYRNEADIGKALRDLLPKYGLSREDIFITSKLAPKDQGYE 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 96 MVLPALERTLKALKLDYIDLYIIELPmafkpGKEIYPRDENGRIIYDKtnlcATWEALEACKDAGLVKSLGVSNFNRRQL 175
Cdd:cd19136 77 KARAACLGSLERLGTDYLDLYLIHWP-----GVQGLKPSDPRNAELRR----ESWRALEDLYKEGKLRAIGVSNYTVRHL 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 176 ELILNKPglKYKPVTNQVECHPYFTQTKLLKFCQQHDIVIVAHSPLGTcrnpswvnvSSPPLLNDELLTSLGKKYNKTQA 255
Cdd:cd19136 148 EELLKYC--EVPPAVNQVEFHPHLVQKELLKFCKDHGIHLQAYSSLGS---------GDLRLLEDPTVLAIAKKYGRTPA 216
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 568941248 256 QIVLRFNIQRGIVVIPKSFTPERIKENFQIFDFSLTEEEMKDIDAL 301
Cdd:cd19136 217 QVLLRWALQQGIGVIPKSTNPERIAENIKVFDFELSEEDMAELNAL 262
|
|
| AKR_AKR5D1_E1 |
cd19132 |
AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B ... |
12-302 |
1.85e-83 |
|
AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B (DkgB) from Corynebacterium sp. and 2,5-diketo-D-gluconic acid reductase Zymomonas mobilis are founding members of aldo-keto reductase family 5 member D1 (AKR5D1) and E1 (AKR5E1), respectively. DkgB (EC 1.1.1.274), also called 2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381358 [Multi-domain] Cd Length: 255 Bit Score: 252.58 E-value: 1.85e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 12 LSDGNNIPLIGLGTYsdprPVPGKTYV-AVKTAIDEGYRHIDGAYVYHNEHEVGEAIREkiaeGKVKREEIFYCGKLWNT 90
Cdd:cd19132 1 LNDGTQIPAIGFGTY----PLKGDEGVeAVVAALQAGYRLLDTAFNYENEGAVGEAVRR----SGVPREELFVTTKLPGR 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 91 EHVPSMVLPALERTLKALKLDYIDLYIIELPMafkPGKEIYprdengriiydktnlCATWEALEACKDAGLVKSLGVSNF 170
Cdd:cd19132 73 HHGYEEALRTIEESLYRLGLDYVDLYLIHWPN---PSRDLY---------------VEAWQALIEAREEGLVRSIGVSNF 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 171 NRRQLELILNKPGLKykPVTNQVECHPYFTQTKLLKFCQQHDIVIVAHSPLGtcRNPSwvnvssppLLNDELLTSLGKKY 250
Cdd:cd19132 135 LPEHLDRLIDETGVT--PAVNQIELHPYFPQAEQRAYHREHGIVTQSWSPLG--RGSG--------LLDEPVIKAIAEKH 202
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 568941248 251 NKTQAQIVLRFNIQRGIVVIPKSFTPERIKENFQIFDFSLTEEEMKDIDALN 302
Cdd:cd19132 203 GKTPAQVVLRWHVQLGVVPIPKSANPERQRENLAIFDFELSDEDMAAIAALD 254
|
|
| AKR_AKR5A_5G |
cd19126 |
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes ... |
10-302 |
6.54e-83 |
|
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes prostaglandin F2-alpha synthase (PGFS) from Leishmania major (AKR5A1) and Trypanosoma brucei (AKR5A2). PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity for synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde. The AKR5G family of AKR includes Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase, which corresponds to aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.
Pssm-ID: 381352 [Multi-domain] Cd Length: 254 Bit Score: 251.20 E-value: 6.54e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 10 ISLSDGNNIPLIGLGTYSDPRPvpGKTYVAVKTAIDEGYRHIDGAYVYHNEHEVGEAIREkiaeGKVKREEIFYCGKLWN 89
Cdd:cd19126 1 VTLNNGTRMPWLGLGVFQTPDG--DETERAVQTALENGYRSIDTAAIYKNEEGVGEAIRE----SGVPREELFVTTKLWN 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 90 TEHVPSMVLPALERTLKALKLDYIDLYIIELPMAfkpgkeiyprdenGRIIydktnlcATWEALEACKDAGLVKSLGVSN 169
Cdd:cd19126 75 DDQRARRTEDAFQESLDRLGLDYVDLYLIHWPGK-------------DKFI-------DTWKALEKLYASGKVKAIGVSN 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 170 FNRRQLELILNKPglKYKPVTNQVECHPYFTQTKLLKFCQQHDIVIVAHSPLGTCRnpswvnvssppLLNDELLTSLGKK 249
Cdd:cd19126 135 FQEHHLEELLAHA--DVVPAVNQVEFHPYLTQKELRGYCKSKGIVVEAWSPLGQGG-----------LLSNPVLAAIGEK 201
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 568941248 250 YNKTQAQIVLRFNIQRGIVVIPKSFTPERIKENFQIFDFSLTEEEMKDIDALN 302
Cdd:cd19126 202 YGKSAAQVVLRWDIQHGVVTIPKSVHASRIKENADIFDFELSEDDMTAIDALN 254
|
|
| AKR_GlAR-like |
cd19128 |
Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), ... |
19-303 |
2.49e-82 |
|
Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), also called aldehyde reductase, is the prototype of this family. It catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
Pssm-ID: 381354 [Multi-domain] Cd Length: 277 Bit Score: 250.52 E-value: 2.49e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 19 PLIGLGTYSDPrpvPGKTYVAVKTAIDEGYRHIDGAYVYHNEHEVGEAIREKIAEGKVKREEIFYCGKLWNTEHVPSMVL 98
Cdd:cd19128 2 PRLGFGTYKIT---ESESKEAVKNAIKAGYRHIDCAYYYGNEAFIGIAFSEIFKDGGVKREDLFITSKLWPTMHQPENVK 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 99 PALERTLKALKLDYIDLYIIELPMAFKPGKEIYPRDENGRIIYDKTNLCATWEALEACKDAGLVKSLGVSNFNRRQLELI 178
Cdd:cd19128 79 EQLLITLQDLQLEYLDLFLIHWPLAFDMDTDGDPRDDNQIQSLSKKPLEDTWRAMEQCVDEKLTKNIGVSNYSTKLLTDL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 179 LNKpgLKYKPVTNQVECHPYFTQTKLLKFCQQHDIVIVAHSPL-GTCRNPSWVnvssppLLNDELLTSLGKKYNKTQAQI 257
Cdd:cd19128 159 LNY--CKIKPFMNQIECHPYFQNDKLIKFCIENNIHVTAYRPLgGSYGDGNLT------FLNDSELKALATKYNTTPPQV 230
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 568941248 258 VLRFNIQR---GIVVIPKSFTPERIKENFQIFDFSLTEEEMkdiDALNK 303
Cdd:cd19128 231 IIAWHLQKwpkNYSVIPKSANKSRCQQNFDINDLALTKEDM---DAINT 276
|
|
| AKR_AKR3F3 |
cd19140 |
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin ... |
15-301 |
3.58e-82 |
|
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381366 [Multi-domain] Cd Length: 253 Bit Score: 249.10 E-value: 3.58e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 15 GNNIPLIGLGTYsdpRPVPGKTYVAVKTAIDEGYRHIDGAYVYHNEHEVGEAIrekiAEGKVKREEIFYCGKLWNTEHVP 94
Cdd:cd19140 5 GVRIPALGLGTY---PLTGEECTRAVEHALELGYRHIDTAQMYGNEAQVGEAI----AASGVPRDELFLTTKVWPDNYSP 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 95 SMVLPALERTLKALKLDYIDLYIIELPMAFKPGKEiyprdengriiydktnlcaTWEALEACKDAGLVKSLGVSNFNRRQ 174
Cdd:cd19140 78 DDFLASVEESLRKLRTDYVDLLLLHWPNKDVPLAE-------------------TLGALNEAQEAGLARHIGVSNFTVAL 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 175 LELILNKPGLKYkpVTNQVECHPYFTQTKLLKFCQQHDIVIVAHSPLGTCRnpswvnvssppLLNDELLTSLGKKYNKTQ 254
Cdd:cd19140 139 LREAVELSEAPL--FTNQVEYHPYLDQRKLLDAAREHGIALTAYSPLARGE-----------VLKDPVLQEIGRKHGKTP 205
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 568941248 255 AQIVLRFNIQR-GIVVIPKSFTPERIKENFQIFDFSLTEEEMKDIDAL 301
Cdd:cd19140 206 AQVALRWLLQQeGVAAIPKATNPERLEENLDIFDFTLSDEEMARIAAL 253
|
|
| AKR_AKR2D1 |
cd19115 |
AKR2D family of aldo-keto reductase (AKR); Aspergillus niger NAD(P)H-dependent D-xylose ... |
9-307 |
4.04e-82 |
|
AKR2D family of aldo-keto reductase (AKR); Aspergillus niger NAD(P)H-dependent D-xylose reductase xyl1 (XR, EC 1.1.1.307) is a founding member of aldo-keto reductase family 2 member D1 (AKR2D1). It catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol in a NAD(P)H dependent manner.
Pssm-ID: 381341 [Multi-domain] Cd Length: 311 Bit Score: 251.19 E-value: 4.04e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 9 QISLSDGNNIPLIGLGTYSDPRPVPGKTyvaVKTAIDEGYRHIDGAYVYHNEHEVGEAIREKIAEGKVKREEIFYCGKLW 88
Cdd:cd19115 4 TVKLNSGYDMPLVGFGLWKVNNDTCADQ---VYNAIKAGYRLFDGACDYGNEVEAGQGVARAIKEGIVKREDLFIVSKLW 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 89 NTEHVPSMVLPALERTLKALKLDYIDLYIIELPMAFK---PGKEiYP---RDENGRIIYDKTNLCATWEALEACKDAGLV 162
Cdd:cd19115 81 NTFHDGERVEPICRKQLADWGIDYFDLFLIHFPIALKyvdPAVR-YPpgwFYDGKKVEFSNAPIQETWTAMEKLVDKGLA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 163 KSLGVSNFnrrQLELILNKpgLKY---KPVTNQVECHPYFTQTKLLKFCQQHDIVIVAHSPLGtcrnP-SWVN------V 232
Cdd:cd19115 160 RSIGVSNF---SAQLLMDL--LRYariRPATLQIEHHPYLTQPRLVKYAQKEGIAVTAYSSFG----PqSFLEldlpgaK 230
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568941248 233 SSPPLLNDELLTSLGKKYNKTQAQIVLRFNIQRGIVVIPKSFTPERIKENFQIFDFSLTEEEMKDIDALNKNVRY 307
Cdd:cd19115 231 DTPPLFEHDVIKSIAEKHGKTPAQVLLRWATQRGIAVIPKSNNPKRLAQNLDVTGFDLEAEEIKAISALDIGLRF 305
|
|
| AKR_AKR5B1 |
cd19127 |
AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) ... |
10-302 |
6.05e-82 |
|
AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) is a founding member of the aldo-keto reductase family 5 member B1 (AKR5B1). M6DH (EC 1.1.1.218), also called naloxone reductase, oxidizes the C-6 hydroxy group of morphine and codeine.
Pssm-ID: 381353 [Multi-domain] Cd Length: 268 Bit Score: 249.25 E-value: 6.05e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 10 ISLSDGNNIPLIGLGTYSDPrpvPGKTYVAVKTAIDEGYRHIDGAYVYHNEHEVGEAIREKiaegKVKREEIFYCGKLWN 89
Cdd:cd19127 1 ITLNNGVEMPALGLGVFQTP---PEETADAVATALADGYRLIDTAAAYGNEREVGEGIRRS----GVDRSDIFVTTKLWI 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 90 TEHVPSMVLPALERTLKALKLDYIDLYIIELPMafkpgkeiyPRDengriiYDKTnlCATWEALEACKDAGLVKSLGVSN 169
Cdd:cd19127 74 SDYGYDKALRGFDASLRRLGLDYVDLYLLHWPV---------PND------FDRT--IQAYKALEKLLAEGRVRAIGVSN 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 170 FNRRQLELILNKPGLKykPVTNQVECHPYFTQTKLLKFCQQHDIVIVAHSPLGTCRNPSWVNVSSPP-LLNDELLTSLGK 248
Cdd:cd19127 137 FTPEHLERLIDATTVV--PAVNQVELHPYFSQKDLRAFHRRLGIVTQAWSPIGGVMRYGASGPTGPGdVLQDPTITGLAE 214
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 568941248 249 KYNKTQAQIVLRFNIQRGIVVIPKSFTPERIKENFQIFDFSLTEEEMKDIDALN 302
Cdd:cd19127 215 KYGKTPAQIVLRWHLQNGVSAIPKSVHPERIAENIDIFDFALSAEDMAAIDALD 268
|
|
| AKR_AKR3C2-3 |
cd19120 |
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis ... |
15-307 |
1.28e-81 |
|
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis NADPH-dependent conjugated polyketone reductase C2 (CPR), and similar proteins; Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase (EC 1.1.1.190/EC 1.1.1.191) and Candida parapsilosis NADPH-dependent CPR (EC 1.1.1.358/EC 1.1.1.168) are founding members of aldo-keto reductase family 3 member C2 (AKR3C2) and C3 (AKR3C3), respectively. Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase catalyzes the conversion from (Indol-3-yl)ethanol to (indol-3-yl)acetaldehyde in a NAD/NADP-dependent manner. CPR, also called 2-dehydropantolactone reductase, or 2-dehydropantolactone reductase (A-specific), or ketopantoyl-lactone reductase, acts as a NADPH-dependent conjugated polyketone reductase with broad substrate specificity and strict stereospecificity. It reduces ketopantoyl lactone and isatin.
Pssm-ID: 381346 [Multi-domain] Cd Length: 269 Bit Score: 248.30 E-value: 1.28e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 15 GNNIPLIGLGT----YSDPRPVPGKTYV-AVKTAIDEGYRHIDGAYVYHNEHEVGEAIREKiaegKVKREEIFYCGKLW- 88
Cdd:cd19120 1 GSKIPAIAFGTgtawYKSGDDDIQRDLVdSVKLALKAGFRHIDTAEMYGNEKEVGEALKES----GVPREDLFITTKVSp 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 89 NTEHVPSmvlpALERTLKALKLDYIDLYIIELPMAFKPGKeiyprdengriiydkTNLCATWEALEACKDAGLVKSLGVS 168
Cdd:cd19120 77 GIKDPRE----ALRKSLAKLGVDYVDLYLIHSPFFAKEGG---------------PTLAEAWAELEALKDAGLVRSIGVS 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 169 NFNRRQLELILNKPglKYKPVTNQVECHPYFT--QTKLLKFCQQHDIVIVAHSPLgtcrNPSWVNVSSPPllnDELLTSL 246
Cdd:cd19120 138 NFRIEDLEELLDTA--KIKPAVNQIEFHPYLYpqQPALLEYCREHGIVVSAYSPL----SPLTRDAGGPL---DPVLEKI 208
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568941248 247 GKKYNKTQAQIVLRFNIQRGIVVIPKSFTPERIKENFQIFDFSLTEEEMKDIDALNKNVRY 307
Cdd:cd19120 209 AEKYGVTPAQVLLRWALQKGIVVVTTSSKEERMKEYLEAFDFELTEEEVEEIDKAGKQKHF 269
|
|
| AKR_AKR3D1 |
cd19121 |
AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, ... |
12-301 |
2.82e-81 |
|
AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, EC 1.1.1.365), also called D-galacturonic acid reductase, or GalUR, is a founding member of aldo-keto reductase family 3 member D1 (AKR3D1). It mediates the reduction of D-galacturonate to L-galactonate, the first step in D-galacturonate catabolic process. It also has activity with D-glucuronate and DL-glyceraldehyde. Its activity is seen only with NADPH and not with NADH.
Pssm-ID: 381347 [Multi-domain] Cd Length: 279 Bit Score: 247.83 E-value: 2.82e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 12 LSDGNNIPLIGLGTYSDPrpvPGKTYVAVKTAIDEGYRHIDGAYVYHNEHEVGEAIREKIAEGkVKREEIFYCGKLWNTE 91
Cdd:cd19121 6 LNTGASIPAVGLGTWQAK---AGEVKAAVAHALKIGYRHIDGALCYQNEDEVGEGIKEAIAGG-VKREDLFVTTKLWSTY 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 92 HvpSMVLPALERTLKALKLDYIDLYIIELPMAFKP--GKEIYPRDENGRIIYDKT-NLCATWEALEACKDAGLVKSLGVS 168
Cdd:cd19121 82 H--RRVELCLDRSLKSLGLDYVDLYLVHWPVLLNPngNHDLFPTLPDGSRDLDWDwNHVDTWKQMEKVLKTGKTKAIGVS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 169 NFNRRQLELILnkPGLKYKPVTNQVECHPYFTQTKLLKFCQQHDIVIVAHSPLGTcrnpswvnvSSPPLLNDELLTSLGK 248
Cdd:cd19121 160 NYSIPYLEELL--KHATVVPAVNQVENHPYLPQQELVDFCKEKGILIEAYSPLGS---------TGSPLISDEPVVEIAK 228
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 568941248 249 KYNKTQAQIVLRFNIQRGIVVIPKSFTPERIKENFQIFDFslTEEEMKDIDAL 301
Cdd:cd19121 229 KHNVGPGTVLISYQVARGAVVLPKSVTPDRIKSNLEIIDL--DDEDMNKLNDI 279
|
|
| AKR_AKR5A1_2 |
cd19156 |
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from ... |
10-307 |
6.68e-81 |
|
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from Leishmania major and Trypanosoma brucei are founding members of aldo-keto reductase family 5 member A1 (AKR5A1) and A2 (AKR5A2), respectively. PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.
Pssm-ID: 381382 [Multi-domain] Cd Length: 266 Bit Score: 246.66 E-value: 6.68e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 10 ISLSDGNNIPLIGLGTYSDPRPvpGKTYVAVKTAIDEGYRHIDGAYVYHNEHEVGEAIREKiaegKVKREEIFYCGKLWN 89
Cdd:cd19156 1 VKLANGVEMPRLGLGVWRVQDG--AEAENAVKWAIEAGYRHIDTAAIYKNEEGVGQGIRES----GVPREEVFVTTKLWN 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 90 TEHVPSMVLPALERTLKALKLDYIDLYIIELPMAFKpgkeiyprdengriiydktnLCATWEALEACKDAGLVKSLGVSN 169
Cdd:cd19156 75 SDQGYESTLAAFEESLEKLGLDYVDLYLIHWPVKGK--------------------FKDTWKAFEKLYKEKKVRAIGVSN 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 170 FNRRQLELILNKpgLKYKPVTNQVECHPYFTQTKLLKFCQQHDIVIVAHSPLGtcrnpswvnvsSPPLLNDELLTSLGKK 249
Cdd:cd19156 135 FHEHHLEELLKS--CKVAPMVNQIELHPLLTQEPLRKFCKEKNIAVEAWSPLG-----------QGKLLSNPVLKAIGKK 201
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 568941248 250 YNKTQAQIVLRFNIQRGIVVIPKSFTPERIKENFQIFDFSLTEEEMKDIDALNKNVRY 307
Cdd:cd19156 202 YGKSAAQVIIRWDIQHGIITIPKSVHEERIQENFDVFDFELTAEEIRQIDGLNTDHRY 259
|
|
| AKR_AKR3C1 |
cd19119 |
Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar ... |
10-301 |
4.78e-77 |
|
Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar proteins; Saccharomyces cerevisiae Ara1p (EC 1.1.1.117), also called D-arabinose 1-dehydrogenase (NAD(P)(+)), is a founding members of aldo-keto reductase family 3 member C1 (AKR3C1). It catalyzes the oxidation of D-arabinose, L-xylose, L-fucose, and L-galactose in the presence of NADP(+).
Pssm-ID: 381345 [Multi-domain] Cd Length: 294 Bit Score: 237.78 E-value: 4.78e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 10 ISLSDGNNIPLIGLGTYSdPRPVPGKTYVAVKTAIDEGYRHIDGAYVYHNEHEVGEAIREKIAEGKVKREEIFYCGKLWN 89
Cdd:cd19119 4 FKLNTGASIPALGLGTAS-PHEDRAEVKEAVEAAIKEGYRHIDTAYAYETEDFVGEAIKRAIDDGSIKREELFITTKVWP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 90 TEHvpSMVLPALERTLKALKLDYIDLYIIELPMAFK-----PGKEIYPRDENGRIIYDKT-NLCATWEALEACKDAGLVK 163
Cdd:cd19119 83 TFY--DEVERSLDESLKALGLDYVDLLLVHWPVCFEkdsddSGKPFTPVNDDGKTRYAASgDHITTYKQLEKIYLDGRAK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 164 SLGVSNFNRRQLELILNKpgLKYKPVTNQVECHPYFTQTKLLKFCQQHDIVIVAHSPLGTcrnpswvnvSSPPLLNDELL 243
Cdd:cd19119 161 AIGVSNYSIVYLERLIKE--CKVVPAVNQVELHPHLPQMDLRDFCFKHGILVTAYSPLGS---------HGAPNLKNPLV 229
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 568941248 244 TSLGKKYNKTQAQIVLRFNIQRGIVVIPKSFTPERIKENFQIfdFSLTEEEMKDIDAL 301
Cdd:cd19119 230 KKIAEKYNVSTGDILISYHVRQGVIVLPKSLKPVRIVSNGKI--VSLTKEDLQKLDDI 285
|
|
| AKR_CeZK1290-like |
cd19135 |
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the ... |
12-301 |
4.65e-75 |
|
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.
Pssm-ID: 381361 [Multi-domain] Cd Length: 265 Bit Score: 231.44 E-value: 4.65e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 12 LSDGNNIPLIGLGT-----YSDPrpvpgktyvAVKTAIDE-GYRHIDGAYVYHNEHEVGEAIREkiaeGKVKREEIFYCG 85
Cdd:cd19135 7 LSNGVEMPILGLGTshsggYSHE---------AVVYALKEcGYRHIDTAKRYGCEELLGKAIKE----SGVPREDLFLTT 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 86 KLWNTEHVPSMVLPALERTLKALKLDYIDLYIIELPMAFKPGKEiyprdengriiyDKTNLCATWEALEACKDAGLVKSL 165
Cdd:cd19135 74 KLWPSDYGYESTKQAFEASLKRLGVDYLDLYLLHWPDCPSSGKN------------VKETRAETWRALEELYDEGLCRAI 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 166 GVSNFNRRQLELILNKPGLKykPVTNQVECHPYFTQTKLLKFCQQHDIVIVAHSPLgtcrnpswvnvSSPPLLNDELLTS 245
Cdd:cd19135 142 GVSNFLIEHLEQLLEDCSVV--PHVNQVEFHPFQNPVELIEYCRDNNIVFEGYCPL-----------AKGKALEEPTVTE 208
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 568941248 246 LGKKYNKTQAQIVLRFNIQRGIVVIPKSFTPERIKENFQIFDFSLTEEEMKDIDAL 301
Cdd:cd19135 209 LAKKYQKTPAQILIRWSIQNGVVTIPKSTKEERIKENCQVFDFSLSEEDMATLDSL 264
|
|
| AKR_AKR5C1 |
cd19130 |
Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; ... |
9-302 |
6.77e-74 |
|
Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; Corynebacterium sp. DkgA is a founding member of aldo-keto reductase family 5 member C1 (AKR5C1). DkgA (EC 1.1.1.346), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). 5-keto-D-fructose and dihydroxyacetone can also serve as substrates.
Pssm-ID: 381356 [Multi-domain] Cd Length: 256 Bit Score: 228.26 E-value: 6.77e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 9 QISLSDGNNIPLIGLGTYSDPrpvPGKTYVAVKTAIDEGYRHIDGAYVYHNEHEVGEAIrekiAEGKVKREEIFYCGKLW 88
Cdd:cd19130 1 SIVLNDGNSIPQLGYGVFKVP---PADTQRAVATALEVGYRHIDTAAIYGNEEGVGAAI----AASGIPRDELFVTTKLW 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 89 NTEHVPSMVLPALERTLKALKLDYIDLYIIELPMafkPGKEIYprdengriiydktnlCATWEALEACKDAGLVKSLGVS 168
Cdd:cd19130 74 NDRHDGDEPAAAFAESLAKLGLDQVDLYLVHWPT---PAAGNY---------------VHTWEAMIELRAAGRTRSIGVS 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 169 NFNRRQLELILNKPGLKykPVTNQVECHPYFTQTKLLKFCQQHDIVIVAHSPLGTCRnpswvnvssppLLNDELLTSLGK 248
Cdd:cd19130 136 NFLPPHLERIVAATGVV--PAVNQIELHPAYQQRTIRDWAQAHDVKIEAWSPLGQGK-----------LLGDPPVGAIAA 202
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 568941248 249 KYNKTQAQIVLRFNIQRGIVVIPKSFTPERIKENFQIFDFSLTEEEMKDIDALN 302
Cdd:cd19130 203 AHGKTPAQIVLRWHLQKGHVVFPKSVRRERMEDNLDVFDFDLTDTEIAAIDALD 256
|
|
| AKR_AKR2C1 |
cd19114 |
AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent ... |
15-313 |
2.95e-73 |
|
AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent 4-dihydromethyl-trisporate dehydrogenase (TDH), also called 4-dihydromethyltrisporate dehydrogenase, or 4-dihydromethyl-TA dehydrogenase, is a founding member of aldo-keto reductase family 2 member C1 (AKR2C1). It is involved in the biosynthesis of trisporic acid, the sexual hormone of zygomycetes, which induces the first steps of zygophore development. TDH catalyzes the NADP-dependent oxidation of (+) mating-type specific precursor 4-dihydromethyl-trisporate to methyl-trisporate.
Pssm-ID: 381340 [Multi-domain] Cd Length: 302 Bit Score: 228.21 E-value: 2.95e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 15 GNNIPLIGLGTYsdpRPVPGKTYVAVKTAIDEGYRHIDGAYVYHNEHEVGEAIREKIAEGKVKREEIFYCGKLWNTEHVP 94
Cdd:cd19114 1 GDKMPLVGFGTA---KIKANETEEVIYNAIKVGYRLIDGALLYGNEAEVGRGIRKAIQEGLVKREDLFIVTKLWNNFHGK 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 95 SMVLPALERTLKALKLDYIDLYIIELPMAFK--PGKEIYP----RDENGRIIYDKTNLCATWEALEACKDAGLVKSLGVS 168
Cdd:cd19114 78 DHVREAFDRQLKDYGLDYIDLYLIHFPIPAAyvDPAENYPflwkDKELKKFPLEQSPMQECWREMEKLVDAGLVRNIGIA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 169 NFNrrqLELILNKpgLKY---KPVTNQVECHPYFTQTKLLKFCQQHDIVIVAHSPLGtcrNPSWVNVSS-----PPLLND 240
Cdd:cd19114 158 NFN---VQLILDL--LTYakiKPAVLQIEHHPYLQQKRLIDWAKKQGIQITAYSSFG---NAVYTKVTKhlkhfTNLLEH 229
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568941248 241 ELLTSLGKKYNKTQAQIVLRFNIQRGIVVIPKSFTPERIKENFQIFDFSLTEEEMKDIDALNKNVRYVELLMW 313
Cdd:cd19114 230 PVVKKLADKHKRDTGQVLLRWAVQRNITVIPKSVNVERMKTNLDITSYKLDEEDMEALYELEANARFNDPVVY 302
|
|
| dkgA |
PRK11565 |
2,5-didehydrogluconate reductase DkgA; |
10-306 |
1.13e-69 |
|
2,5-didehydrogluconate reductase DkgA;
Pssm-ID: 183203 [Multi-domain] Cd Length: 275 Bit Score: 218.02 E-value: 1.13e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 10 ISLSDGNNIPLIGLGTY--SDPRPVpgktyVAVKTAIDEGYRHIDGAYVYHNEHEVGEAIREkiaeGKVKREEIFYCGKL 87
Cdd:PRK11565 7 IKLQDGNVMPQLGLGVWqaSNEEVI-----TAIHKALEVGYRSIDTAAIYKNEEGVGKALKE----ASVAREELFITTKL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 88 WNTEHvpSMVLPALERTLKALKLDYIDLYIIELPMafkPGKEIYprdengriiydktnlCATWEALEACKDAGLVKSLGV 167
Cdd:PRK11565 78 WNDDH--KRPREALEESLKKLQLDYVDLYLMHWPV---PAIDHY---------------VEAWKGMIELQKEGLIKSIGV 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 168 SNFNRRQLELILNKPGLKykPVTNQVECHPYFTQTKLLKFCQQHDIVIVAHSPLGTcrnpswvnvSSPPLLNDELLTSLG 247
Cdd:PRK11565 138 CNFQIHHLQRLIDETGVT--PVINQIELHPLMQQRQLHAWNATHKIQTESWSPLAQ---------GGKGVFDQKVIRDLA 206
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 568941248 248 KKYNKTQAQIVLRFNIQRGIVVIPKSFTPERIKENFQIFDFSLTEEEMKDIDALNKNVR 306
Cdd:PRK11565 207 DKYGKTPAQIVIRWHLDSGLVVIPKSVTPSRIAENFDVFDFRLDKDELGEIAKLDQGKR 265
|
|
| AKR_AKR5H1 |
cd19134 |
AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding ... |
10-307 |
7.94e-66 |
|
AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding member of aldo-keto reductase family 5 member H1 (AKR5H1). It is a NADPH-dependent aldo-keto reductase that reduces methylglyoxal and phenylglyoxal.
Pssm-ID: 381360 [Multi-domain] Cd Length: 263 Bit Score: 207.79 E-value: 7.94e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 10 ISLSDGNNIPLIGLGTY--SDprpvpGKTYVAVKTAIDEGYRHIDGAYVYHNEHEVGEAIrekiAEGKVKREEIFYCGKL 87
Cdd:cd19134 3 VTLNDDNTMPVIGLGVGelSD-----DEAERSVSAALEAGYRLIDTAAAYGNEAAVGRAI----AASGIPRGELFVTTKL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 88 WNTEHVPSMVLPALERTLKALKLDYIDLYIIELPMAfKPGKEIyprdengriiydktnlcATWEALEACKDAGLVKSLGV 167
Cdd:cd19134 74 ATPDQGFTASQAACRASLERLGLDYVDLYLIHWPAG-REGKYV-----------------DSWGGLMKLREEGLARSIGV 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 168 SNFNRRQLELILNKPGlkYKPVTNQVECHPYFTQTKLLKFCQQHDIVIVAHSPLGTCRnpswvnvssppLLNDELLTSLG 247
Cdd:cd19134 136 SNFTAEHLENLIDLTF--FTPAVNQIELHPLLNQAELRKVNAQHGIVTQAYSPLGVGR-----------LLDNPAVTAIA 202
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 248 KKYNKTQAQIVLRFNIQRGIVVIPKSFTPERIKENFQIFDFSLTEEEMKDIDALNKNVRY 307
Cdd:cd19134 203 AAHGRTPAQVLLRWSLQLGNVVISRSSNPERIASNLDVFDFELTADHMDALDGLDDGTRF 262
|
|
| AKR_AKR3F2 |
cd19139 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; ... |
18-301 |
2.14e-65 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381365 [Multi-domain] Cd Length: 248 Bit Score: 206.44 E-value: 2.14e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 18 IPLIGLGTYsdpRPVPGKTYVAVKTAIDEGYRHIDGAYVYHNEHEVGEAIrekiAEGKVKREEIFYCGKLWNTEHVPSMV 97
Cdd:cd19139 1 IPAFGLGTF---RLKDDVVIDSVRTALELGYRHIDTAQIYDNEAAVGQAI----AESGVPRDELFITTKIWIDNLSKDKL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 98 LPALERTLKALKLDYIDLYIIELPMafkpgkeiyprdengriIYDKTNLCATWEALEACKDAGLVKSLGVSNFNRRQLEL 177
Cdd:cd19139 74 LPSLEESLEKLRTDYVDLTLIHWPS-----------------PNDEVPVEEYIGALAEAKEQGLTRHIGVSNFTIALLDE 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 178 ILNKPGlKYKPVTNQVECHPYFTQTKLLKFCQQHDIVIVAHSPLGTCRnpswvnvssppLLNDELLTSLGKKYNKTQAQI 257
Cdd:cd19139 137 AIAVVG-AGAIATNQIELSPYLQNRKLVAHCKQHGIHVTSYMTLAYGK-----------VLDDPVLAAIAERHGATPAQI 204
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 568941248 258 VLRFNIQRGIVVIPKSFTPERIKENFQIFDFSLTEEEMKDIDAL 301
Cdd:cd19139 205 ALAWAMARGYAVIPSSTKREHLRSNLLALDLTLDADDMAAIAAL 248
|
|
| AKR_AKR3E1 |
cd19122 |
AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol ... |
11-303 |
2.23e-65 |
|
AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol 2-dehydrogenase (GLD2, EC 1.1.1.156), also called dihydroxyacetone reductase, is a founding member of aldo-keto reductase family 3 member E1 (AKR3E1). It acts as a glycerol oxidoreductase probably involved in glycerol synthesis.
Pssm-ID: 381348 [Multi-domain] Cd Length: 291 Bit Score: 207.86 E-value: 2.23e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 11 SLSDGNNIPLIGLGTYSDpRPVPGKTYVAVKTAIDEGYRHIDGAYVYHNEHEVGEAIREKIAEG-KVKREEIFYCGKLWN 89
Cdd:cd19122 2 TLNNGVKIPAVGFGTFAN-EGAKGETYAAVTKALDVGYRHLDCAWFYLNEDEVGDAVRDFLKENpSVKREDLFICTKVWN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 90 TEHVPSMVLPALERTLKALKLDYIDLYIIELPMAFKPGKEIYPR-DENGRIIYDKT---NLCATWEALEACKDAGLVKSL 165
Cdd:cd19122 81 HLHEPEDVKWSIDNSLKNLKLDYIDLFLVHWPIAAEKNDQRSPKlGPDGKYVILKDlteNPEPTWRAMEEIYESGKAKAI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 166 GVSNFNRRQLELILNKPglKYKPVTNQVECHPYFTQTKLLKFCQQHDIVIVAHSPLGTCRN-PSW-VNVSSPPLLNDell 243
Cdd:cd19122 161 GVSNWTIPGLKKLLSFA--KVKPHVNQIEIHPFLPNEELVDYCFSNDILPEAYSPLGSQNQvPSTgERVSENPTLNE--- 235
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 244 tsLGKKYNKTQAQIVLRFNIQRGIVVIPKSFTPERIKENFQIFDFSlteeeMKDIDALNK 303
Cdd:cd19122 236 --VAEKGGYSLAQVLIAWGLRRGYVVLPKSSTPSRIESNFKSIELS-----DEDFEAINQ 288
|
|
| AKR_AKR3F1-like |
cd19072 |
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime ... |
15-299 |
2.90e-58 |
|
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase. Escherichia coli YeaE may act as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381298 [Multi-domain] Cd Length: 263 Bit Score: 188.59 E-value: 2.90e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 15 GNNIPLIGLGTY------SDPRPVPGKTYVAVKTAIDEGYRHIDGAYVY---HNEHEVGEAIRekiaegKVKREEIFYCG 85
Cdd:cd19072 1 GEEVPVLGLGTWgigggmSKDYSDDKKAIEALRYAIELGINLIDTAEMYgggHAEELVGKAIK------GFDREDLFITT 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 86 KLWNTEHVPSMVLPALERTLKALKLDYIDLYIIELPMAFKPGKEiyprdengriiydktnlcaTWEALEACKDAGLVKSL 165
Cdd:cd19072 75 KVSPDHLKYDDVIKAAKESLKRLGTDYIDLYLIHWPNPSIPIEE-------------------TLRAMEELVEEGKIRYI 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 166 GVSNFNRRQLELILNKPGlKYKPVTNQVECHPYFT--QTKLLKFCQQHDIVIVAHSPLGTCRnpswvnvssppLLNDE-- 241
Cdd:cd19072 136 GVSNFSLEELEEAQSYLK-KGPIVANQVEYNLFDReeESGLLPYCQKNGIAIIAYSPLEKGK-----------LSNAKgs 203
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 242 -LLTSLGKKYNKTQAQIVLRFNIQR-GIVVIPKSFTPERIKENFQIFDFSLTEEEMKDID 299
Cdd:cd19072 204 pLLDEIAKKYGKTPAQIALNWLISKpNVIAIPKASNIEHLEENAGALGWELSEEDLQRLD 263
|
|
| Aldo_ket_red |
pfam00248 |
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain ... |
21-302 |
2.56e-56 |
|
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.
Pssm-ID: 425554 [Multi-domain] Cd Length: 290 Bit Score: 184.44 E-value: 2.56e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 21 IGLGTYS----DPRPVPGKTYVAVKTAIDEGYRHIDGAYVYH---NEHEVGEAIREKiaegKVKREEIFYCGKL------ 87
Cdd:pfam00248 1 IGLGTWQlgggWGPISKEEALEALRAALEAGINFIDTAEVYGdgkSEELLGEALKDY----PVKRDKVVIATKVpdgdgp 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 88 WNTEHVPSMVLPALERTLKALKLDYIDLYIIELPmafkpgKEIYPRDEngriiydktnlcaTWEALEACKDAGLVKSLGV 167
Cdd:pfam00248 77 WPSGGSKENIRKSLEESLKRLGTDYIDLYYLHWP------DPDTPIEE-------------TWDALEELKKEGKIRAIGV 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 168 SNFNRRQLELILNKPglKYKPVTNQVECHPYF--TQTKLLKFCQQHDIVIVAHSPLG----------------TCRNPSW 229
Cdd:pfam00248 138 SNFDAEQIEKALTKG--KIPIVAVQVEYNLLRrrQEEELLEYCKKNGIPLIAYSPLGgglltgkytrdpdkgpGERRRLL 215
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568941248 230 VNVSSPPLLNDELLTSLGKKYNKTQAQIVLRF--NIQRGIVVIPKSFTPERIKENFQIFDFSLTEEEMKDIDALN 302
Cdd:pfam00248 216 KKGTPLNLEALEALEEIAKEHGVSPAQVALRWalSKPGVTIPIPGASNPEQLEDNLGALEFPLSDEEVARIDELL 290
|
|
| dkgB |
PRK11172 |
2,5-didehydrogluconate reductase DkgB; |
17-308 |
7.02e-51 |
|
2,5-didehydrogluconate reductase DkgB;
Pssm-ID: 183012 [Multi-domain] Cd Length: 267 Bit Score: 169.43 E-value: 7.02e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 17 NIPLIGLGTYSdprpVPGKTYVA-VKTAIDEGYRHIDGAYVYHNEHEVGEAIrekiAEGKVKREEIFYCGKLWNTEHVPS 95
Cdd:PRK11172 2 SIPAFGLGTFR----LKDQVVIDsVKTALELGYRAIDTAQIYDNEAAVGQAI----AESGVPRDELFITTKIWIDNLAKD 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 96 MVLPALERTLKALKLDYIDLYIIELPmafKPGKEIyprdengriiydktNLCATWEALEACKDAGLVKSLGVSNFNRRQL 175
Cdd:PRK11172 74 KLIPSLKESLQKLRTDYVDLTLIHWP---SPNDEV--------------SVEEFMQALLEAKKQGLTREIGISNFTIALM 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 176 ELILNKPGlKYKPVTNQVECHPYFTQTKLLKFCQQHDIVIVAHSPLGTCRnpswvnvssppLLNDELLTSLGKKYNKTQA 255
Cdd:PRK11172 137 KQAIAAVG-AENIATNQIELSPYLQNRKVVAFAKEHGIHVTSYMTLAYGK-----------VLKDPVIARIAAKHNATPA 204
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 568941248 256 QIVLRFNIQRGIVVIPKSFTPERIKENFQIFDFSLTEEEMKDIDALNKNVRYV 308
Cdd:PRK11172 205 QVILAWAMQLGYSVIPSSTKRENLASNLLAQDLQLDAEDMAAIAALDRNGRLV 257
|
|
| AKR_AKR3F1 |
cd19137 |
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding ... |
15-299 |
3.72e-47 |
|
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381363 [Multi-domain] Cd Length: 260 Bit Score: 159.66 E-value: 3.72e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 15 GNNIPLIGLGT----------YSDPRPVPGktyvAVKTAIDEGYRHIDGAYVY---HNEHEVGEAIREkiaegkVKREEI 81
Cdd:cd19137 1 GEKIPALGLGTwgiggfltpdYSRDEEMVE----LLKTAIELGYTHIDTAEMYgggHTEELVGKAIKD------FPREDL 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 82 FYCGKLWNTEHVPSMVLPALERTLKALKLDYIDLYIIELpmafkPGKEIyPRDEngriiydktnlcaTWEALEACKDAGL 161
Cdd:cd19137 71 FIVTKVWPTNLRYDDLLRSLQNSLRRLDTDYIDLYLIHW-----PNPNI-PLEE-------------TLSAMAEGVRQGL 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 162 VKSLGVSNFNRRQLELILNKpgLKYKPVTNQVECHPY---FTQTKLLKFCQQHDIVIVAHSPLgtcrnpswvnvSSPPLL 238
Cdd:cd19137 132 IRYIGVSNFNRRLLEEAISK--SQTPIVCNQVKYNLEdrdPERDGLLEYCQKNGITVVAYSPL-----------RRGLEK 198
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568941248 239 NDELLTSLGKKYNKTQAQIVLRFNIQR-GIVVIPKSFTPERIKENFQIFDFSLTEEEMKDID 299
Cdd:cd19137 199 TNRTLEEIAKNYGKTIAQIALAWLIQKpNVVAIPKAGRVEHLKENLKATEIKLSEEEMKLLD 260
|
|
| AKR_YeaE |
cd19138 |
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this ... |
8-299 |
2.39e-44 |
|
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this family. It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381364 [Multi-domain] Cd Length: 266 Bit Score: 152.40 E-value: 2.39e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 8 HQISLSDGNNIPLIGLGTY---SDPRPvPGKTYVAVKTAIDEGYRHIDGAYVYHN---EHEVGEAIREKiaegkvkREEI 81
Cdd:cd19138 1 RTVTLPDGTKVPALGQGTWymgEDPAK-RAQEIEALRAGIDLGMTLIDTAEMYGDggsEELVGEAIRGR-------RDKV 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 82 FYCGKLWNTEHVPSMVLPALERTLKALKLDYIDLYIIELPMAfkpgkeiYPRDEngriiydktnlcaTWEALEACKDAGL 161
Cdd:cd19138 73 FLVSKVLPSNASRQGTVRACERSLRRLGTDYLDLYLLHWRGG-------VPLAE-------------TVAAMEELKKEGK 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 162 VKSLGVSNFNRRQLELILNKPGLKyKPVTNQVECH-----PYFTqtkLLKFCQQHDIVIVAHSPLGTCRNPSWVnvsspp 236
Cdd:cd19138 133 IRAWGVSNFDTDDMEELWAVPGGG-NCAANQVLYNlgsrgIEYD---LLPWCREHGVPVMAYSPLAQGGLLRRG------ 202
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568941248 237 LLNDELLTSLGKKYNKTQAQIVLRFNIQRGIVV-IPKSFTPERIKENFQIFDFSLTEEEMKDID 299
Cdd:cd19138 203 LLENPTLKEIAARHGATPAQVALAWVLRDGNVIaIPKSGSPEHARENAAAADLELTEEDLAELD 266
|
|
| AKR_AtPLR-like |
cd19093 |
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR ... |
18-299 |
5.72e-40 |
|
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR (EC 1.1.1.65) is the prototype of this family. It catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+), and is involved in the PLP salvage pathway.
Pssm-ID: 381319 [Multi-domain] Cd Length: 293 Bit Score: 141.98 E-value: 5.72e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 18 IPLIGLGTYS--DPRPVPGKTYV------AVKTAIDEGYRHIDGAYVY---HNEHEVGEAIREKiaegkVKREEIFYCGK 86
Cdd:cd19093 2 VSPLGLGTWQwgDRLWWGYGEYGdedlqaAFDAALEAGVNLFDTAEVYgtgRSERLLGRFLKEL-----GDRDEVVIATK 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 87 LWNT--EHVPSMVLPALERTLKALKLDYIDLYIIELPMAFKPGkeiyprdengriiydktnLCATWEALEACKDAGLVKS 164
Cdd:cd19093 77 FAPLpwRLTRRSVVKALKASLERLGLDSIDLYQLHWPGPWYSQ------------------IEALMDGLADAVEEGLVRA 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 165 LGVSNFNRRQLELI---LNKPGlkYKPVTNQVE---CHPYFTQTKLLKFCQQHDIVIVAHSPLG--------TCRNP--- 227
Cdd:cd19093 139 VGVSNYSADQLRRAhkaLKERG--VPLASNQVEyslLYRDPEQNGLLPACDELGITLIAYSPLAqglltgkySPENPppg 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 228 ---------SWVNVssPPLLndELLTSLGKKYNKTQAQIVLRFNIQRGIVVIPKSFTPERIKENFQIFDFSLTEEEMKDI 298
Cdd:cd19093 217 grrrlfgrkNLEKV--QPLL--DALEEIAEKYGKTPAQVALNWLIAKGVVPIPGAKNAEQAEENAGALGWRLSEEEVAEL 292
|
.
gi 568941248 299 D 299
Cdd:cd19093 293 D 293
|
|
| AKR_AKR11B1-like |
cd19084 |
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called ... |
17-299 |
1.60e-35 |
|
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.
Pssm-ID: 381310 [Multi-domain] Cd Length: 296 Bit Score: 130.34 E-value: 1.60e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 17 NIPLIGLGTYS----DPRPVPGKTYV-AVKTAIDEGYRHIDGAYVY---HNEHEVGEAIrekiaegKVKREEIFY---CG 85
Cdd:cd19084 3 KVSRIGLGTWAiggtWWGEVDDQESIeAIKAAIDLGINFFDTAPVYgfgHSEEILGKAL-------KGRRDDVVIatkCG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 86 KLWNTEHV------PSMVLPALERTLKALKLDYIDLYIIELPmafkpgkeiyprDENgriiydkTNLCATWEALEACKDA 159
Cdd:cd19084 76 LRWDGGKGvtkdlsPESIRKEVEQSLRRLQTDYIDLYQIHWP------------DPN-------TPIEETAEALEKLKKE 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 160 GLVKSLGVSNFNRRQLELIlnkpgLKY-KPVTNQVECHPYFTQT--KLLKFCQQHDIVIVAHSPLGT------------- 223
Cdd:cd19084 137 GKIRYIGVSNFSVEQLEEA-----RKYgPIVSLQPPYSMLEREIeeELLPYCRENGIGVLPYGPLAQglltgkykkeptf 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 224 ----CRNPSwvnvsspPLLNDEL----------LTSLGKKYNKTQAQIVLRFNIQR--GIVVIPKSFTPERIKENFQIFD 287
Cdd:cd19084 212 ppddRRSRF-------PFFRGENfeknleivdkLKEIAEKYGKSLAQLAIAWTLAQpgVTSAIVGAKNPEQLEENAGALD 284
|
330
....*....|..
gi 568941248 288 FSLTEEEMKDID 299
Cdd:cd19084 285 WELTEEELKEID 296
|
|
| AKR_AKR11B3 |
cd19085 |
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is ... |
39-305 |
1.06e-33 |
|
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is a founding member of aldo-keto reductase family 11 member B3(AKR11B3). It is responsible for methylglyoxal detoxification.
Pssm-ID: 381311 [Multi-domain] Cd Length: 292 Bit Score: 125.39 E-value: 1.06e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 39 AVKTAIDEGYRHIDGAYVY---HNEHEVGEAIREKiaegkvkREEIFYCGKLWNTEHVPSMVLPALERTLKALKLDYIDL 115
Cdd:cd19085 28 TIHAALDAGINFFDTAEAYgdgHSEEVLGKALKGR-------RDDVVIATKVSPDNLTPEDVRKSCERSLKRLGTDYIDL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 116 YIIELPMAFKPGKEiyprdengriiydktnlcaTWEALEACKDAGLVKSLGVSNFNRRQLELILnKPGlkyKPVTNQVEC 195
Cdd:cd19085 101 YQIHWPSSDVPLEE-------------------TMEALEKLKEEGKIRAIGVSNFGPAQLEEAL-DAG---RIDSNQLPY 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 196 HPYFTQ--TKLLKFCQQHDIVIVAHSPLG----TCRNPSwvNVSSPPllND---------------------ELLTSLGK 248
Cdd:cd19085 158 NLLWRAieYEILPFCREHGIGVLAYSPLAqgllTGKFSS--AEDFPP--GDartrlfrhfepgaeeetfealEKLKEIAD 233
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 568941248 249 KYNKTQAQIVLRFNIQRGIV--VIPKSFTPERIKENFQIFDFSLTEEEMKDIDALNKNV 305
Cdd:cd19085 234 ELGVTMAQLALAWVLQQPGVtsVIVGARNPEQLEENAAAVDLELSPSVLERLDEISDPL 292
|
|
| PdxI |
COG0667 |
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme ... |
15-301 |
5.14e-32 |
|
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme transport and metabolism, General function prediction only];
Pssm-ID: 440431 [Multi-domain] Cd Length: 316 Bit Score: 121.44 E-value: 5.14e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 15 GNNIPLIGLGTYS---DPRPVPGKTYVA-VKTAIDEGYRHIDGAYVY---HNEHEVGEAIREKiaegkvKREEIFYCGKL 87
Cdd:COG0667 10 GLKVSRLGLGTMTfggPWGGVDEAEAIAiLDAALDAGINFFDTADVYgpgRSEELLGEALKGR------PRDDVVIATKV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 88 --------WNTEHVPSMVLPALERTLKALKLDYIDLYIIELPmafkpgkeiyprDENgriiydkTNLCATWEALEACKDA 159
Cdd:COG0667 84 grrmgpgpNGRGLSREHIRRAVEASLRRLGTDYIDLYQLHRP------------DPD-------TPIEETLGALDELVRE 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 160 GLVKSLGVSNFNRRQLELILNKPGLKYKPVTNQVEchpY--FTQT---KLLKFCQQHDIVIVAHSPL------GTCRNPS 228
Cdd:COG0667 145 GKIRYIGVSNYSAEQLRRALAIAEGLPPIVAVQNE---YslLDRSaeeELLPAARELGVGVLAYSPLagglltGKYRRGA 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 229 WVNVSS-------PPLLNDEL------LTSLGKKYNKTQAQIVLRFNIQRG--IVVIPKSFTPERIKENFQIFDFSLTEE 293
Cdd:COG0667 222 TFPEGDraatnfvQGYLTERNlalvdaLRAIAAEHGVTPAQLALAWLLAQPgvTSVIPGARSPEQLEENLAAADLELSAE 301
|
....*...
gi 568941248 294 EMKDIDAL 301
Cdd:COG0667 302 DLAALDAA 309
|
|
| YdhF |
COG4989 |
Predicted oxidoreductase YdhF [General function prediction only]; |
39-294 |
3.29e-26 |
|
Predicted oxidoreductase YdhF [General function prediction only];
Pssm-ID: 444013 [Multi-domain] Cd Length: 299 Bit Score: 105.23 E-value: 3.29e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 39 AVKTAIDEGYRHIDGAYVYHN---EHEVGEAIREKiaegKVKREEIFY---CG------------KLWNT--EHVpsmvL 98
Cdd:COG4989 36 LIEAALELGITTFDHADIYGGytcEALFGEALKLS----PSLREKIELqtkCGirlpseardnrvKHYDTskEHI----I 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 99 PALERTLKALKLDYIDLYIIELPMAFKPGKEIyprdengriiydktnlcAtwEALEACKDAGLVKSLGVSNFNRRQLELi 178
Cdd:COG4989 108 ASVEGSLRRLGTDYLDLLLLHRPDPLMDPEEV-----------------A--EAFDELKASGKVRHFGVSNFTPSQFEL- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 179 LNKpGLKYKPVTNQVECHPYFTQT---KLLKFCQQHDIVIVAHSPLGTCRnpsWVNVSSP--PLLNdELLTSLGKKYNKT 253
Cdd:COG4989 168 LQS-ALDQPLVTNQIELSLLHTDAfddGTLDYCQLNGITPMAWSPLAGGR---LFGGFDEqfPRLR-AALDELAEKYGVS 242
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 568941248 254 QAQIVLRFnIQR---GIVVIPKSFTPERIKENFQIFDFSLTEEE 294
Cdd:COG4989 243 PEAIALAW-LLRhpaGIQPVIGTTNPERIKAAAAALDIELTREE 285
|
|
| AKR_SF |
cd06660 |
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of ... |
21-284 |
1.08e-24 |
|
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications. Members have very distinct functions and include the prokaryotic 2,5-diketo-D-gluconic acid reductases and beta-keto ester reductases, the eukaryotic aldose reductases, aldehyde reductases, hydroxysteroid dehydrogenases, steroid 5beta-reductases, potassium channel beta-subunits, and aflatoxin aldehyde reductases, among others.
Pssm-ID: 381296 [Multi-domain] Cd Length: 232 Bit Score: 99.52 E-value: 1.08e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 21 IGLGTYSDPRPVPGKTYVA-VKTAIDEGYRHIDGAYVY---HNEHEVGEAIREKiaegkVKREEIFYCGKL---WNTEHV 93
Cdd:cd06660 3 LGLGTMTFGGDGDEEEAFAlLDAALEAGGNFFDTADVYgdgRSERLLGRWLKGR-----GNRDDVVIATKGghpPGGDPS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 94 PSMVLPA-----LERTLKALKLDYIDLYIIElpmafkpgkeiypRDEngriiyDKTNLCATWEALEACKDAGLVKSLGVS 168
Cdd:cd06660 78 RSRLSPEhirrdLEESLRRLGTDYIDLYYLH-------------RDD------PSTPVEETLEALNELVREGKIRYIGVS 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 169 NFNRRQLELILN--KPGLKYKPVTNQVE---CHPYFTQTKLLKFCQQHDIVIVAHSPLGtcRNPswvnvssppllndell 243
Cdd:cd06660 139 NWSAERLAEALAyaKAHGLPGFAAVQPQyslLDRSPMEEELLDWAEENGLPLLAYSPLA--RGP---------------- 200
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 568941248 244 tslgkkynktqAQIVLRF--NIQRGIVVIPKSFTPERIKENFQ 284
Cdd:cd06660 201 -----------AQLALAWllSQPFVTVPIVGARSPEQLEENLA 232
|
|
| AKR_AKR11A1_11D1 |
cd19083 |
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto ... |
21-301 |
3.09e-24 |
|
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto reductase IolS, also called vegetative protein 147 (VEG147), is a founding member of aldo-keto reductase family 11 member A1 (AKR11A1). It is able to reduce the standard aldo-keto reductase (AKR) substrates DL-glyceraldehyde, D-erythrose, and methylglyoxal in the presence of NADPH, albeit with poor efficiency in vitro. Bacillus aryabhattai aldo keto reductase is a founding member of aldo-keto reductase family 11 member D1 (AKR11D1).
Pssm-ID: 381309 [Multi-domain] Cd Length: 307 Bit Score: 100.19 E-value: 3.09e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 21 IGLGT--------YSDPRPVPGKTYVavKTAIDEGYRHIDGAYVY---HNEHEVGEAIREKiaegkvKREEIFYC--GKL 87
Cdd:cd19083 14 IGLGTnavgghnlYPNLDEEEGKDLV--REALDNGVNLLDTAFIYglgRSEELVGEVLKEY------NRNEVVIAtkGAH 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 88 WNTEH------VPSMVLPALERTLKALKLDYIDLYIIELPmafkpgKEIYPRDEngriiydktnlcaTWEALEACKDAGL 161
Cdd:cd19083 86 KFGGDgsvlnnSPEFLRSAVEKSLKRLNTDYIDLYYIHFP------DGETPKAE-------------AVGALQELKDEGK 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 162 VKSLGVSNFNRRQLELiLNKPGL------KYKPVTNQVECHpyftqtkLLKFCQQHDIVIVAHSPLG------------T 223
Cdd:cd19083 147 IRAIGVSNFSLEQLKE-ANKDGYvdvlqgEYNLLQREAEED-------ILPYCVENNISFIPYFPLAsgllagkytkdtK 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 224 CRNPSWVNvsSPPLLNDEL----------LTSLGKKYNKTQAQIVLRFNIQR-GI-VVIPKSFTPERIKENFQIFDFSLT 291
Cdd:cd19083 219 FPDNDLRN--DKPLFKGERfsenldkvdkLKSIADEKGVTVAHLALAWYLTRpAIdVVIPGAKRAEQVIDNLKALDVTLT 296
|
330
....*....|
gi 568941248 292 EEEMKDIDAL 301
Cdd:cd19083 297 EEEIAFIDAL 306
|
|
| AKR_unchar |
cd19102 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
39-301 |
7.00e-24 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381328 [Multi-domain] Cd Length: 302 Bit Score: 99.28 E-value: 7.00e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 39 AVKTAIDEGYRHIDGAYVY---HNEHEVGEAIREKiaegkvkREEIFY---CGKLWNTE------HVPSMVLPALERTLK 106
Cdd:cd19102 31 AIRAALDLGINWIDTAAVYglgHSEEVVGRALKGL-------RDRPIVatkCGLLWDEEgrirrsLKPASIRAECEASLR 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 107 ALKLDYIDLYIIELPmafkpgkeiyPRDENgriiydktnLCATWEALEACKDAGLVKSLGVSNFNRRQLELIlnkpgLKY 186
Cdd:cd19102 104 RLGVDVIDLYQIHWP----------DPDEP---------IEEAWGALAELKEEGKVRAIGVSNFSVDQMKRC-----QAI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 187 KPVT-NQVechPYF-----TQTKLLKFCQQHDIVIVAHSPLG----TCR-NPSWVNVSSP-------PLLNDELLT---- 244
Cdd:cd19102 160 HPIAsLQP---PYSllrrgIEAEILPFCAEHGIGVIVYSPMQsgllTGKmTPERVASLPAddwrrrsPFFQEPNLArnla 236
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568941248 245 ------SLGKKYNKTQAQIVLRFNIQRGIV--VIPKSFTPERIKENFQIFDFSLTEEEMKDIDAL 301
Cdd:cd19102 237 lvdalrPIAERHGRTVAQLAIAWVLRRPEVtsAIVGARRPDQIDETVGAADLRLTPEELAEIEAL 301
|
|
| AKR_BsYcsN_EcYdhF-like |
cd19092 |
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and ... |
39-294 |
2.68e-22 |
|
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and Escherichia coli YdhF are prototypes of this family. They are uncharacterized aldo/keto reductase family oxidoreductases.
Pssm-ID: 381318 [Multi-domain] Cd Length: 287 Bit Score: 94.55 E-value: 2.68e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 39 AVKTAIDEGYRHIDGAYVYHN---EHEVGEAIREKiaegKVKREEIFY---CG-------KLWNTEHV---PSMVLPALE 102
Cdd:cd19092 29 LIEAALELGITTFDHADIYGGgkcEELFGEALALN----PGLREKIEIqtkCGirlgddpRPGRIKHYdtsKEHILASVE 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 103 RTLKALKLDYIDLYIIELPMAFKPGKEiyprdengriiydktnlcaTWEALEACKDAGLVKSLGVSNFNRRQLELiLNKp 182
Cdd:cd19092 105 GSLKRLGTDYLDLLLLHRPDPLMDPEE-------------------VAEAFDELVKSGKVRYFGVSNFTPSQIEL-LQS- 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 183 GLKYKPVTNQVEC---HPYFTQTKLLKFCQQHDIVIVAHSPLG-----TCRNPSWVNVSsppllndELLTSLGKKYNKTQ 254
Cdd:cd19092 164 YLDQPLVTNQIELsllHTEAIDDGTLDYCQLLDITPMAWSPLGggrlfGGFDERFQRLR-------AALEELAEEYGVTI 236
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 568941248 255 AQIVLRFnIQR---GIVVIPKSFTPERIKENFQIFDFSLTEEE 294
Cdd:cd19092 237 EAIALAW-LLRhpaRIQPILGTTNPERIRSAVKALDIELTREE 278
|
|
| AKR_AKR13A1 |
cd19144 |
AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC ... |
14-298 |
9.96e-20 |
|
AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor.
Pssm-ID: 381370 [Multi-domain] Cd Length: 323 Bit Score: 87.88 E-value: 9.96e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 14 DGNNIPLIGLGT-----YSDPRPVPGKTYVAVKTAIDEGYRHIDGAYVY-HNEHEVGEAIreKIAEGKvkREEIFYCGKL 87
Cdd:cd19144 9 NGPSVPALGFGAmglsaFYGPPKPDEERFAVLDAAFELGCTFWDTADIYgDSEELIGRWF--KQNPGK--REKIFLATKF 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 88 WNTEHV----------PSMVLPALERTLKALKLDYIDLYiielpmafkpgkeiYPRDENGRIIYDKtnlcaTWEALEACK 157
Cdd:cd19144 85 GIEKNVetgeysvdgsPEYVKKACETSLKRLGVDYIDLY--------------YQHRVDGKTPIEK-----TVAAMAELV 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 158 DAGLVKSLGVSNFNRRQLelilnKPGLKYKPVTN-QVECHPYFT-----QTKLLKFCQQHDIVIVAHSPL------GTCR 225
Cdd:cd19144 146 QEGKIKHIGLSECSAETL-----RRAHAVHPIAAvQIEYSPFSLdierpEIGVLDTCRELGVAIVAYSPLgrgfltGAIR 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 226 NP---------------SWVNVSSPPLLNDElLTSLGKKYNKTQAQIVLRFNIQRG--IVVIPKSFTPERIKENFQIFDF 288
Cdd:cd19144 221 SPddfeegdfrrmaprfQAENFPKNLELVDK-IKAIAKKKNVTAGQLTLAWLLAQGddIIPIPGTTKLKRLEENLGALKV 299
|
330
....*....|
gi 568941248 289 SLTEEEMKDI 298
Cdd:cd19144 300 KLTEEEEKEI 309
|
|
| AKR_AKR11B2 |
cd19149 |
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; ... |
18-300 |
3.21e-19 |
|
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.
Pssm-ID: 381375 [Multi-domain] Cd Length: 315 Bit Score: 86.56 E-value: 3.21e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 18 IPLIGLGTYS---DPRPVPGKTYVAVKT---AIDEGYRHIDGAYVY---HNEHEVGEAIREKiaegkvkREEIFY---CG 85
Cdd:cd19149 11 ASVIGLGTWAiggGPWWGGSDDNESIRTihaALDLGINLIDTAPAYgfgHSEEIVGKAIKGR-------RDKVVLatkCG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 86 KLWNTE---HV-------------PSMVLPALERTLKALKLDYIDLYIIELPMAFKPGKEiyprdengriiydktnlcaT 149
Cdd:cd19149 84 LRWDREggsFFfvrdgvtvyknlsPESIREEVEQSLKRLGTDYIDLYQTHWQDVETPIEE-------------------T 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 150 WEALEACKDAGLVKSLGVSNFNRRQL-------ELILNKPglKYKPVTNQVEchpyftqTKLLKFCQQHDIVIVAHSPL- 221
Cdd:cd19149 145 MEALEELKRQGKIRAIGASNVSVEQIkeyvkagQLDIIQE--KYSMLDRGIE-------KELLPYCKKNNIAFQAYSPLe 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 222 ----------------GTCRNPS-WVNVSSPPLLND--ELLTSLGKKYNKTQAQIVLRFNIQRG--IVVIPKSFTPERIK 280
Cdd:cd19149 216 qglltgkitpdrefdaGDARSGIpWFSPENREKVLAllEKWKPLCEKYGCTLAQLVIAWTLAQPgiTSALCGARKPEQAE 295
|
330 340
....*....|....*....|
gi 568941248 281 ENFQIFDFSLTEEEMKDIDA 300
Cdd:cd19149 296 ENAKAGDIRLSAEDIATMRS 315
|
|
| AKR_AKR11B1 |
cd19148 |
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also ... |
21-301 |
2.09e-18 |
|
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381374 [Multi-domain] Cd Length: 302 Bit Score: 83.90 E-value: 2.09e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 21 IGLGTY---------SDPRpvpgKTYVAVKTAIDEGYRHIDGAYVY---HNEHEVGEAIrekiaEGKVKREEIFY---CG 85
Cdd:cd19148 7 IALGTWaiggwmwggTDEK----EAIETIHKALDLGINLIDTAPVYgfgLSEEIVGKAL-----KEYGKRDRVVIatkVG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 86 KLWNTEHV------PSMVLPALERTLKALKLDYIDLYIIELPmafkpgKEIYPRDEngriiydktnlcaTWEALEACKDA 159
Cdd:cd19148 78 LEWDEGGEvvrnssPARIRKEVEDSLRRLQTDYIDLYQVHWP------DPLVPIEE-------------TAEALKELLDE 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 160 GLVKSLGVSNFNRRQLELIlnkpgLKYKPV-TNQVechPY--FTQT---KLLKFCQQHDIVIVAHSPLgtCR-------- 225
Cdd:cd19148 139 GKIRAIGVSNFSPEQMETF-----RKVAPLhTVQP---PYnlFEREiekDVLPYARKHNIVTLAYGAL--CRgllsgkmt 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 226 -------------NPSWVNVSSPPLLN--DELLTSLGKKYNKTQAQIVLRFNIQRGIVVIP--KSFTPERIKENFQIFDF 288
Cdd:cd19148 209 kdtkfegddlrrtDPKFQEPRFSQYLAavEELDKLAQERYGKSVIHLAVRWLLDQPGVSIAlwGARKPEQLDAVDEVFGW 288
|
330
....*....|...
gi 568941248 289 SLTEEEMKDIDAL 301
Cdd:cd19148 289 SLNDEDMKEIDAI 301
|
|
| AKR_AKR13B1 |
cd19088 |
AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde ... |
19-291 |
2.52e-18 |
|
AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde dehydrogenase is a founding member of aldo-keto reductase family 13 member B1 (AKR13B1). phenylacetaldehyde dehydrogenase (EC 1.2.1.39) catalyzes the NAD+-dependent oxidation of phenylactealdehyde to phenylacetic acid.
Pssm-ID: 381314 [Multi-domain] Cd Length: 256 Bit Score: 82.65 E-value: 2.52e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 19 PLIGLGTYSDPRPvPGKTYVAVKTAIDEGYRHIDGAYVY---HNEHEVGEAIRE-----KIAE--GKVKREeifycGKLW 88
Cdd:cd19088 10 RLTGPGIWGPPAD-REEAIAVLRRALELGVNFIDTADSYgpdVNERLIAEALHPypddvVIATkgGLVRTG-----PGWW 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 89 NTEHVPSMVLPALERTLKALKLDYIDLYIIELPMAFkpgkeiYPRDEngriiydktnlcaTWEALEACKDAGLVKSLGVS 168
Cdd:cd19088 84 GPDGSPEYLRQAVEASLRRLGLDRIDLYQLHRIDPK------VPFEE-------------QLGALAELQDEGLIRHIGLS 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 169 NFNRRQLELILNKPGLkykpVTNQVECHPYFTQT-KLLKFCQQHDIVIVAHSPLGtcrnpswvnvSSPPLLNDELLTSLG 247
Cdd:cd19088 145 NVTVAQIEEARAIVRI----VSVQNRYNLANRDDeGVLDYCEAAGIAFIPWFPLG----------GGDLAQPGGLLAEVA 210
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 568941248 248 KKYNKTQAQIVLRFNIQRG--IVVIPKSFTPERIKENFQIFDFSLT 291
Cdd:cd19088 211 ARLGATPAQVALAWLLARSpvMLPIPGTSSVEHLEENLAAAGLRLS 256
|
|
| AKR_AKR11C1 |
cd19086 |
AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase ... |
21-282 |
3.08e-17 |
|
AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase YqkF is a founding member of aldo-keto reductase family 11 member C1 (AKR11C1). It may function as oxidoreductase. This family also includes Bacillus halodurans AKR11C1, an NADPH-dependent 4-hydroxy-2,3-trans-nonenal reductase.
Pssm-ID: 381312 [Multi-domain] Cd Length: 238 Bit Score: 79.44 E-value: 3.08e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 21 IGLGTYSdprpVPGKTYV---------AVKTAIDEGYRHIDGAYVY---HNEHEVGEAIREKiaegkvkREEI------- 81
Cdd:cd19086 6 IGFGTWG----LGGDWWGdvddaeairALRAALDLGINFFDTADVYgdgHSERLLGKALKGR-------RDKVviatkfg 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 82 --FYCGKLWNTEHVPSMVLPALERTLKALKLDYIDLYIIELPMAfkpgkEIYPRDEngriiydktnlcaTWEALEACKDA 159
Cdd:cd19086 75 nrFDGGPERPQDFSPEYIREAVEASLKRLGTDYIDLYQLHNPPD-----EVLDNDE-------------LFEALEKLKQE 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 160 GLVKSLGVSNFNRRQLELILNKPGLK-----YkpvtNQVECHPYftqTKLLKFCQQHDIVIVAHSPLgtcrnpswvnvss 234
Cdd:cd19086 137 GKIRAYGVSVGDPEEALAALRRGGIDvvqviY----NLLDQRPE---EELFPLAEEHGVGVIARVPL------------- 196
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 568941248 235 ppllnDE-LLTslGKKynktqAQIVLRFNIQRGIV--VIPKSFTPERIKEN 282
Cdd:cd19086 197 -----ASgLLT--GKL-----AQAALRFILSHPAVstVIPGARSPEQVEEN 235
|
|
| AKR_AKR8A1-2 |
cd19077 |
AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding ... |
21-299 |
2.19e-16 |
|
AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding members of aldo-keto reductase family 8 member A1-2 (AKR8A1-2), respectively. PLR (EC 1.1.1.65), also called PL reductase (PL-red), catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+).
Pssm-ID: 381303 [Multi-domain] Cd Length: 302 Bit Score: 78.05 E-value: 2.19e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 21 IGLGTYS---DPRPVPGKTYVAV-KTAIDEGYRHIDGAYVY------HNEHEVGEAIReKIAEgkvKREEIFYC--GKLW 88
Cdd:cd19077 8 IGLGLMGltwRPNPTPDEEAFETmKAALDAGSNLWNGGEFYgppdphANLKLLARFFR-KYPE---YADKVVLSvkGGLD 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 89 NTEHVP----SMVLPALERTLKALK-LDYIDLYiielpmafkpgkeiyprdENGRIiYDKTNLCATWEALEACKDAGLVK 163
Cdd:cd19077 84 PDTLRPdgspEAVRKSIENILRALGgTKKIDIF------------------EPARV-DPNVPIEETIKALKELVKEGKIR 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 164 SLGVSNFNRRQLELILnkpglKYKPVT-NQVECHPYFT---QTKLLKFCQQHDIVIVAHSPLG----TCRNPSWVNV--- 232
Cdd:cd19077 145 GIGLSEVSAETIRRAH-----AVHPIAaVEVEYSLFSReieENGVLETCAELGIPIIAYSPLGrgllTGRIKSLADIpeg 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 233 ---SSPPLLNDE----------LLTSLGKKYNKTQAQIVLRFNIQRG---IVVIPKSFTPERIKENFQIFDFSLTEEEMK 296
Cdd:cd19077 220 dfrRHLDRFNGEnfeknlklvdALQELAEKKGCTPAQLALAWILAQSgpkIIPIPGSTTLERVEENLKAANVELTDEELK 299
|
...
gi 568941248 297 DID 299
Cdd:cd19077 300 EIN 302
|
|
| AKR_unchar |
cd19105 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
15-168 |
4.26e-16 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381331 [Multi-domain] Cd Length: 250 Bit Score: 76.47 E-value: 4.26e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 15 GNNIPLIGLGTYSDPRPVPGktyvAVKTAIDEGYRHIDGAYVY---HNEHEVGEAIRekiaegKVKREEIFYCGKLWNTE 91
Cdd:cd19105 10 GLKVSRLGFGGGGLPRESPE----LLRRALDLGINYFDTAEGYgngNSEEIIGEALK------GLRRDKVFLATKASPRL 79
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568941248 92 HV--PSMVLPALERTLKALKLDYIDLYiieLPMAFKPGKEIYPRDEngriIYdktnlcatwEALEACKDAGLVKSLGVS 168
Cdd:cd19105 80 DKkdKAELLKSVEESLKRLQTDYIDIY---QLHGVDTPEERLLNEE----LL---------EALEKLKKEGKVRFIGFS 142
|
|
| AKR_unchar |
cd19100 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
15-222 |
1.74e-15 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381326 [Multi-domain] Cd Length: 238 Bit Score: 74.44 E-value: 1.74e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 15 GNNIPLIGLGTYSDPRPVPGKTYVAVKTAIDEGYRHIDGAYVYHNEHE-VGEAIREKiaegkvkREEIFYCGKLWNTEhv 93
Cdd:cd19100 8 GLKVSRLGFGGGPLGRLSQEEAAAIIRRALDLGINYFDTAPSYGDSEEkIGKALKGR-------RDKVFLATKTGARD-- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 94 PSMVLPALERTLKALKLDYIDLYII-------ELPMAFKPGkeiyprdengriiydktnlcATWEALEACKDAGLVKSLG 166
Cdd:cd19100 79 YEGAKRDLERSLKRLGTDYIDLYQLhavdteeDLDQVFGPG--------------------GALEALLEAKEEGKIRFIG 138
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568941248 167 VSNFNRRQLELILNKPglkykPV------TNQVECHPYFTQTKLLKFCQQHDIVIVAHSPLG 222
Cdd:cd19100 139 ISGHSPEVLLRALETG-----EFdvvlfpINPAGDHIDSFREELLPLAREKGVGVIAMKVLA 195
|
|
| AKR_AKR15A-like |
cd19090 |
AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes ... |
21-293 |
2.14e-15 |
|
AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH) and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. The family also includes L-galactose dehydrogenase (L-galDH) and D-arabinose 1-dehydrogenase (ARA2). L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381316 [Multi-domain] Cd Length: 278 Bit Score: 74.90 E-value: 2.14e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 21 IGLGTY---SDPRPVPGKTYVA-VKTAIDEGYRHIDGAYVYHN-EHEVGEAIREkiaegkVKREEIFYCGKL-----WNT 90
Cdd:cd19090 3 LGLGTAglgGVFGGVDDDEAVAtIRAALDLGINYIDTAPAYGDsEERLGLALAE------LPREPLVLSTKVgrlpeDTA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 91 EHVPSMVLPALERTLKALKLDYIDLYIIELPMAFKPGKEIYPrdenGRIIydktnlcatwEALEACKDAGLVKSLGVS-- 168
Cdd:cd19090 77 DYSADRVRRSVEESLERLGRDRIDLLMIHDPERVPWVDILAP----GGAL----------EALLELKEEGLIKHIGLGgg 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 169 --NFNRRQLElilnkpglkykpvTNQVEC---HPYFT------QTKLLKFCQQHDIVIVAHSPLG----TCRNPSWVNVS 233
Cdd:cd19090 143 ppDLLRRAIE-------------TGDFDVvltANRYTlldqsaADELLPAAARHGVGVINASPLGmgllAGRPPERVRYT 209
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568941248 234 SPPLLNDEL-----LTSLGKKYNKTQAQIVLRF--NIQRGIVVIPKSFTPERIKENFQIFDFSLTEE 293
Cdd:cd19090 210 YRWLSPELLdrakrLYELCDEHGVPLPALALRFllRDPRISTVLVGASSPEELEQNVAAAEGPLPEE 276
|
|
| AKR_unchar |
cd19099 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
21-222 |
3.71e-15 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381325 [Multi-domain] Cd Length: 316 Bit Score: 74.66 E-value: 3.71e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 21 IGLGTYS-DPRPVPGKTYV-AVKTAIDEGYRHIDGAYVYHN---EHEVGEAIREKIAEGKVKREEIFYC---GKLwnTEH 92
Cdd:cd19099 6 LGLGTYRgDSDDETDEEYReALKAALDSGINVIDTAINYRGgrsERLIGKALRELIEKGGIKRDEVVIVtkaGYI--PGD 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 93 VPSMVLP--------------------------------ALERTLKALKLDYIDLYIIELPmafkpgkEIYPRDENGRII 140
Cdd:cd19099 84 GDEPLRPlkyleeklgrglidvadsaglrhcispayledQIERSLKRLGLDTIDLYLLHNP-------EEQLLELGEEEF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 141 YDKtnLCATWEALEACKDAGLVKSLGVSNFN------------------RRQLELILNKPGLKYkpVtnQVECHPYFTQ- 201
Cdd:cd19099 157 YDR--LEEAFEALEEAVAEGKIRYYGISTWDgfrappalpghlsleklvAAAEEVGGDNHHFKV--I--QLPLNLLEPEa 230
|
250 260 270
....*....|....*....|....*....|..
gi 568941248 202 -----------TKLLKFCQQHDIVIVAHSPLG 222
Cdd:cd19099 231 ltekntvkgeaLSLLEAAKELGLGVIASRPLN 262
|
|
| AKR_EcYajO-like |
cd19079 |
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this ... |
21-296 |
6.09e-15 |
|
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.
Pssm-ID: 381305 [Multi-domain] Cd Length: 312 Bit Score: 74.16 E-value: 6.09e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 21 IGLGTYSDPRPvPGKTYVA--------VKTAIDEGYRHIDGAYVYHN---EHEVGEAIREKIaegkvKREEIFYCGKLWN 89
Cdd:cd19079 15 LCLGCMSFGDP-KWRPWVLdeeesrpiIKRALDLGINFFDTANVYSGgasEEILGRALKEFA-----PRDEVVIATKVYF 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 90 -TEHVPSM-------VLPALERTLKALKLDYIDLYIIElpmafkpgkeiyprdengRIIYDkTNLCATWEALEACKDAGL 161
Cdd:cd19079 89 pMGDGPNGrglsrkhIMAEVDASLKRLGTDYIDLYQIH------------------RWDYE-TPIEETLEALHDVVKSGK 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 162 VKSLGVSNFNRRQLELILN---KPGLKyKPVTNQvechPYFT------QTKLLKFCQQHDIVIVAHSPL--GTCRNPSWV 230
Cdd:cd19079 150 VRYIGASSMYAWQFAKALHlaeKNGWT-KFVSMQ----NHYNllyreeEREMIPLCEEEGIGVIPWSPLarGRLARPWGD 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 231 NVSSPPLLND-----------------ELLTSLGKKYNKTQAQIVLRFNIQRGIVVIP--KSFTPERIKENFQIFDFSLT 291
Cdd:cd19079 225 TTERRRSTTDtaklkydyfteadkeivDRVEEVAKERGVSMAQVALAWLLSKPGVTAPivGATKLEHLEDAVAALDIKLS 304
|
....*
gi 568941248 292 EEEMK 296
Cdd:cd19079 305 EEEIK 309
|
|
| AKR_Fe-S_oxidoreductase |
cd19096 |
Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S ... |
19-287 |
1.56e-14 |
|
Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S oxidoreductase that belongs to aldo-keto reductase (AKR) superfamily. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381322 [Multi-domain] Cd Length: 255 Bit Score: 72.21 E-value: 1.56e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 19 PLIGLGTY-----SDPRPVPGKTYVAVKTAIDEGYRHIDGAYVYHN---EHEVGEAIREkiaegkVKREEIFYCGKL-WN 89
Cdd:cd19096 1 SVLGFGTMrlpesDDDSIDEEKAIEMIRYAIDAGINYFDTAYGYGGgksEEILGEALKE------GPREKFYLATKLpPW 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 90 TEHVPSMVLPALERTLKALKLDYIDLYII------ELPMAFKPGKeiyprdengriiydktnlcaTWEALEACKDAGLVK 163
Cdd:cd19096 75 SVKSAEDFRRILEESLKRLGVDYIDFYLLhglnspEWLEKARKGG--------------------LLEFLEKAKKEGLIR 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 164 SLGVS------NFNRrqlelILNkpglkykpvTNQVEC----HPYFTQ-----TKLLKFCQQHDIVIVAHSPLGTCRNPs 228
Cdd:cd19096 135 HIGFSfhdspeLLKE-----ILD---------SYDFDFvqlqYNYLDQenqagRPGIEYAAKKGMGVIIMEPLKGGGLA- 199
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568941248 229 wvnvSSPPLLNDELltslgKKYNKTQAQIVLRFNI-QRGIVVIPKSF-TPERIKENFQIFD 287
Cdd:cd19096 200 ----NNPPEALAIL-----CGAPLSPAEWALRFLLsHPEVTTVLSGMsTPEQLDENIAAAD 251
|
|
| COG1453 |
COG1453 |
Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only]; |
15-301 |
2.43e-14 |
|
Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only];
Pssm-ID: 441062 [Multi-domain] Cd Length: 365 Bit Score: 72.93 E-value: 2.43e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 15 GNNIPLIGLGTYSDPRPVPGKTYVAVKTAIDEGYRHIDGAYVYHN-EHEVGEAIREKiaegkvkREEIFYCGKLWNTEHV 93
Cdd:COG1453 10 GLEVSVLGFGGMRLPRKDEEEAEALIRRAIDNGINYIDTARGYGDsEEFLGKALKGP-------RDKVILATKLPPWVRD 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 94 PSMVLPALERTLKALKLDYIDLYII-------ELPMAFKPGkEIYprdengriiydktnlcatwEALEACKDAGLVKSLG 166
Cdd:COG1453 83 PEDMRKDLEESLKRLQTDYIDLYLIhglnteeDLEKVLKPG-GAL-------------------EALEKAKAEGKIRHIG 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 167 VSNFNRRQ-LELILNkpglkykpvTNQVEC-----HPYFTQ----TKLLKFCQQHDIVIVAHSPL--GTCRNPSwvnvss 234
Cdd:COG1453 143 FSTHGSLEvIKEAID---------TGDFDFvqlqyNYLDQDnqagEEALEAAAEKGIGVIIMKPLkgGRLANPP------ 207
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568941248 235 ppllnDELLTSLGKKYnkTQAQIVLRF--NIQRGIVVIPKSFTPERIKENFQIFD--FSLTEEEMKDIDAL 301
Cdd:COG1453 208 -----EKLVELLCPPL--SPAEWALRFllSHPEVTTVLSGMSTPEQLDENLKTADnlEPLTEEELAILERL 271
|
|
| AKR_unchar |
cd19103 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
39-301 |
8.35e-13 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381329 [Multi-domain] Cd Length: 299 Bit Score: 67.74 E-value: 8.35e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 39 AVKTAIDEGYRHIDGAYVYhnehevGEAIREKIAeGKV----KREEIFYcgklwNTEHVPSM-------VLPALERTLKA 107
Cdd:cd19103 37 VFDKAMAAGLNLWDTAAVY------GMGASEKIL-GEFlkryPREDYII-----STKFTPQIagqsadpVADMLEGSLAR 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 108 LKLDYIDLYIIELPMAFKpgkeiyprdengriiydktnlcaTW-EALEACKDAGLVKSLGVSNFNRRQLEL---ILNKPG 183
Cdd:cd19103 105 LGTDYIDIYWIHNPADVE-----------------------RWtPELIPLLKSGKVKHVGVSNHNLAEIKRaneILAKAG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 184 LKYKPVTNQVE-CHPYFTQTKLLKFCQQHDIVIVAHS-----------------PLGTCRNPSWvNVSSPPL--LNDeLL 243
Cdd:cd19103 162 VSLSAVQNHYSlLYRSSEEAGILDYCKENGITFFAYMvleqgalsgkydtkhplPEGSGRAETY-NPLLPQLeeLTA-VM 239
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 568941248 244 TSLGKKYNKTQAQIVLRFNIQRGIVVIPKSFTPERIKENFQIFDFSLTEEEMKDIDAL 301
Cdd:cd19103 240 AEIGAKHGASIAQVAIAWAIAKGTTPIIGVTKPHHVEDAARAASITLTDDEIKELEQL 297
|
|
| AKR_PsAKR |
cd19091 |
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an ... |
40-301 |
1.15e-12 |
|
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an uncharacterized aldo-keto reductase from Polaromonas sp.
Pssm-ID: 381317 [Multi-domain] Cd Length: 319 Bit Score: 67.64 E-value: 1.15e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 40 VKTAIDEGYRHIDGAYVYHN---EHEVGEAIREKiaegkvkREEIFYCGK--LWNTEHVPSM------VLPALERTLKAL 108
Cdd:cd19091 45 VDIALDAGINFFDTADVYSEgesEEILGKALKGR-------RDDVLIATKvrGRMGEGPNDVglsrhhIIRAVEASLKRL 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 109 KLDYIDLYIIELPMAFKPGKEiyprdengriiydktnlcaTWEALEACKDAGLVKSLGVSNFNRRQLELIL---NKPGLK 185
Cdd:cd19091 118 GTDYIDLYQLHGFDALTPLEE-------------------TLRALDDLVRQGKVRYIGVSNFSAWQIMKALgisERRGLA 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 186 yKPVTNQVechpYFT------QTKLLKFCQQHDIVIVAHSPLGTCR----------NPSWVNVSS----PPLLNDEL--- 242
Cdd:cd19091 179 -RFVALQA----YYSllgrdlEHELMPLALDQGVGLLVWSPLAGGLlsgkyrrgqpAPEGSRLRRtgfdFPPVDRERgyd 253
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568941248 243 ----LTSLGKKYNKTQAQIVLRFNIQRGIV--VIPKSFTPERIKENFQIFDFSLTEEEMKDIDAL 301
Cdd:cd19091 254 vvdaLREIAKETGATPAQVALAWLLSRPTVssVIIGARNEEQLEDNLGAAGLSLTPEEIARLDKV 318
|
|
| AKR_PA4992-like |
cd19095 |
Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the ... |
21-282 |
1.57e-12 |
|
Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the prototype of this family. It is a putative aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381321 [Multi-domain] Cd Length: 253 Bit Score: 66.49 E-value: 1.57e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 21 IGLGTYS--DPRPVPGKTYVA--VKTAIDEGYRHIDGAYVYHN-EHEVGEAIREkiaegkVKREEIFYCGKLWNT----- 90
Cdd:cd19095 3 LGLGTSGigRVWGVPSEAEAArlLNTALDLGINLIDTAPAYGRsEERLGRALAG------LRRDDLFIATKVGTHgeggr 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 91 ---EHVPSMVLPALERTLKALKLDYIDLYIIElpmafKPGkeiyPRDENGRIIydktnlcatwEALEACKDAGLVKSLGV 167
Cdd:cd19095 77 drkDFSPAAIRASIERSLRRLGTDYIDLLQLH-----GPS----DDELTGEVL----------ETLEDLKAAGKVRYIGV 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 168 SNFNrrqlelilnkPGLKYKPVTNQVEC--HPY----FTQTKLLKFCQQHDIVIVAHSPLGTCRNPSWVNVSSPPLLNDE 241
Cdd:cd19095 138 SGDG----------EELEAAIASGVFDVvqLPYnvldREEEELLPLAAEAGLGVIVNRPLANGRLRRRVRRRPLYADYAR 207
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 568941248 242 LLTSLGKKYNKTQAQIVLRFNIQRGIV--VIPKSFTPERIKEN 282
Cdd:cd19095 208 RPEFAAEIGGATWAQAALRFVLSHPGVssAIVGTTNPEHLEEN 250
|
|
| AKR_unchar |
cd19101 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
153-300 |
3.47e-12 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381327 [Multi-domain] Cd Length: 304 Bit Score: 66.08 E-value: 3.47e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 153 LEACKDAGLVKSLGVSNFNRRQLELILNKPglkYKPVTNQVEC-----HPyftQTKLLKFCQQHDIVIVAHSPL-GTCRN 226
Cdd:cd19101 128 LAELQEEGKIRHLGLTNFDTERLREILDAG---VPIVSNQVQYslldrRP---ENGMAALCEDHGIKLLAYGTLaGGLLS 201
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 227 PSWVNVSSPP--------------LLND--------ELLTSL---GKKYNKTQAQIVLRFNIQR---GIVVIPKSFTpER 278
Cdd:cd19101 202 EKYLGVPEPTgpaletrslqkyklMIDEwggwdlfqELLRTLkaiADKHGVSIANVAVRWVLDQpgvAGVIVGARNS-EH 280
|
170 180
....*....|....*....|..
gi 568941248 279 IKENFQIFDFSLTEEEMKDIDA 300
Cdd:cd19101 281 IDDNVRAFSFRLDDEDRAAIDA 302
|
|
| AKR_AKR13A_13D |
cd19076 |
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto ... |
43-298 |
3.60e-12 |
|
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor. Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.
Pssm-ID: 381302 [Multi-domain] Cd Length: 303 Bit Score: 65.70 E-value: 3.60e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 43 AIDEGYRHIDGAYVY---HNEHEVGEAIREKiaegkvkREEIFY---CGKLWN--TEHV-----PSMVLPALERTLKALK 109
Cdd:cd19076 41 ALELGVTFLDTADMYgpgTNEELLGKALKDR-------RDEVVIatkFGIVRDpgSGFRgvdgrPEYVRAACEASLKRLG 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 110 LDYIDLYIIelpmafkpgkeiyprdengRIIYDKTNLCATWEALEACKDAGLVKSLGVSNFN----RR----------QL 175
Cdd:cd19076 114 TDVIDLYYQ-------------------HRVDPNVPIEETVGAMAELVEEGKVRYIGLSEASadtiRRahavhpitavQS 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 176 ElilnkpglkYKPVTNQVEchpyftqTKLLKFCQQHDIVIVAHSPLGtcRNPSWVNVSSPPLL----------------- 238
Cdd:cd19076 175 E---------YSLWTRDIE-------DEVLPTCRELGIGFVAYSPLG--RGFLTGAIKSPEDLpeddfrrnnprfqgenf 236
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568941248 239 --NDELLTSLGK---KYNKTQAQIVLRFNIQRG--IVVIPKSFTPERIKENFQIFDFSLTEEEMKDI 298
Cdd:cd19076 237 dkNLKLVEKLEAiaaEKGCTPAQLALAWVLAQGddIVPIPGTKRIKYLEENVGALDVVLTPEELAEI 303
|
|
| AKR_AKR13C1_2 |
cd19078 |
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli ... |
40-299 |
9.82e-12 |
|
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli aldehyde reductase (AKR13C1) and Thermotoga maritima aldo-keto reductase (AKR13C2). Aldehyde reductase (EC 1.1.1.21), also called aldose reductase, is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides.
Pssm-ID: 381304 [Multi-domain] Cd Length: 301 Bit Score: 64.56 E-value: 9.82e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 40 VKTAIDEGYRHIDGAYVY---HNEHEVGEAIrekiaegKVKREEIFYCGKL-WNTEHV----------PSMVLPALERTL 105
Cdd:cd19078 31 IRKAVELGITFFDTAEVYgpyTNEELVGEAL-------KPFRDQVVIATKFgFKIDGGkpgplgldsrPEHIRKAVEGSL 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 106 KALKLDYIDLYIIElpmafkpgkeiyprdengRIiyDK-TNLCATWEALEACKDAGLVKSLGVS----NFNRRqleliln 180
Cdd:cd19078 104 KRLQTDYIDLYYQH------------------RV--DPnVPIEEVAGTMKELIKEGKIRHWGLSeagvETIRR------- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 181 kpGLKYKPVTN-QVECHPYFT--QTKLLKFCQQHDIVIVAHSPLG-----------TCRNPSWVNVSSP----------- 235
Cdd:cd19078 157 --AHAVCPVTAvQSEYSMMWRepEKEVLPTLEELGIGFVPFSPLGkgfltgkidenTKFDEGDDRASLPrftpealeanq 234
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568941248 236 PLLndELLTSLGKKYNKTQAQIVLRFNIQRG--IVVIPKSFTPERIKENFQIFDFSLTEEEMKDID 299
Cdd:cd19078 235 ALV--DLLKEFAEEKGATPAQIALAWLLAKKpwIVPIPGTTKLSRLEENIGAADIELTPEELREIE 298
|
|
| AKR_Tas-like |
cd19094 |
Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the ... |
43-301 |
5.40e-11 |
|
Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the prototype of this family. It is an NADP(H)-dependent aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NADP(H) as a hydride donor.
Pssm-ID: 381320 [Multi-domain] Cd Length: 328 Bit Score: 62.58 E-value: 5.40e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 43 AIDEGYRHIDGAYVY---HNEHEVGEAirEKIA----EGKVKREEIFYCGKL--------WNTEHVPSM----VLPALER 103
Cdd:cd19094 27 AFDEGVNFIDTAEMYpvpPSPETQGRT--EEIIgswlKKKGNRDKVVLATKVagpgegitWPRGGGTRLdrenIREAVEG 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 104 TLKALKLDYIDLYIIELPMAFKP-GKEIYPRDENGRiiYDKTNLCATWEALEACKDAGLVKSLGVSN--------FNR-- 172
Cdd:cd19094 105 SLKRLGTDYIDLYQLHWPDRYTPlFGGGYYTEPSEE--EDSVSFEEQLEALGELVKAGKIRHIGLSNetpwgvmkFLEla 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 173 RQLELilnkPglkyKPVTNQvecHPY--FTQTK---LLKFCQQHDIVIVAHSPLG--------------TCR-----NPS 228
Cdd:cd19094 183 EQLGL----P----RIVSIQ---NPYslLNRNFeegLAEACHRENVGLLAYSPLAggvltgkyldgaarPEGgrlnlFPG 251
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568941248 229 WVN--VSSPPLLNDELLTSLGKKYNKTQAQIVLRFNIQRGIV--VIPKSFTPERIKENFQIFDFSLTEEEMKDIDAL 301
Cdd:cd19094 252 YMAryRSPQALEAVAEYVKLARKHGLSPAQLALAWVRSRPFVtsTIIGATTLEQLKENIDAFDVPLSDELLAEIDAV 328
|
|
| Aldo_ket_red_shaker-like |
cd19074 |
Shaker potassium channel beta subunit family and similar proteins; This family includes ... |
40-293 |
8.30e-10 |
|
Shaker potassium channel beta subunit family and similar proteins; This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. The family also includes Drosophila melanogaster Hk protein, a founding member of aldo-keto reductase family 6 member B1 (AKR6B1), as well as voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa, founding members of AKR6C1and AKR6C2, respectively. Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381300 [Multi-domain] Cd Length: 297 Bit Score: 58.76 E-value: 8.30e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 40 VKTAIDEGYRHIDGAYVYHN---EHEVGEAIRekiaegKVKREEIFYCGKL-WNT-----------EHVpsmvLPALERT 104
Cdd:cd19074 28 VRKAYDLGINFFDTADVYAAgqaEEVLGKALK------GWPRESYVISTKVfWPTgpgpndrglsrKHI----FESIHAS 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 105 LKALKLDYIDLYIIELPmafkpgkeiyprDENgriiydkTNLCATWEALEACKDAGLVKSLGVSNFNRRQLE--LILNKP 182
Cdd:cd19074 98 LKRLQLDYVDIYYCHRY------------DPE-------TPLEETVRAMDDLIRQGKILYWGTSEWSAEQIAeaHDLARQ 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 183 GLKYKPVTNQVECHPYFTQ--TKLLKFCQQHDIVIVAHSPL-----------------GTCRNPSWVNVSSPPLLNDEL- 242
Cdd:cd19074 159 FGLIPPVVEQPQYNMLWREieEEVIPLCEKNGIGLVVWSPLaqglltgkyrdgipppsRSRATDEDNRDKKRRLLTDENl 238
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568941248 243 -----LTSLGKKYNKTQAQI----VLRfniQRGI--VVIPKSfTPERIKENFQIFDFSLTEE 293
Cdd:cd19074 239 ekvkkLKPIADELGLTLAQLalawCLR---NPAVssAIIGAS-RPEQLEENVKASGVKLSPE 296
|
|
| AKR_AKR9C1 |
cd19081 |
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a ... |
100-299 |
2.09e-09 |
|
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a founding member of aldo-keto reductase family 9 member C1 (AKR9C1).
Pssm-ID: 381307 [Multi-domain] Cd Length: 308 Bit Score: 57.61 E-value: 2.09e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 100 ALERTLKALKLDYIDLYIIELPmafkpgkeiyprDENgriiydkTNLCATWEALEACKDAGLVKSLGVSNFNRRQLELIL 179
Cdd:cd19081 103 AVEASLRRLQTDYIDLYQAHWD------------DPA-------TPLEETLGALNDLIRQGKVRYIGASNYSAWRLQEAL 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 180 N---KPGLKyKPVTNQVEchpY------FTQTKLLKFCQQHDIVIVAHSPL----------------GTCRNPSWVNvss 234
Cdd:cd19081 164 ElsrQHGLP-RYVSLQPE---YnlvdreSFEGELLPLCREEGIGVIPYSPLaggfltgkyrseadlpGSTRRGEAAK--- 236
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568941248 235 pPLLND------ELLTSLGKKYNKTQAQIVLRFNIQRGIV--VIPKSFTPERIKENFQIFDFSLTEEEMKDID 299
Cdd:cd19081 237 -RYLNErglrilDALDEVAAEHGATPAQVALAWLLARPGVtaPIAGARTVEQLEDLLAAAGLRLTDEEVARLD 308
|
|
| AKR_AKR7A1-5 |
cd19075 |
AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1 ... |
45-222 |
2.27e-08 |
|
AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1/AKR7A3/AFAR) from Rattus norvegicus, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR1/AFAR) and aflatoxin B1 aldehyde reductase member 3 (AKR7A3/AFAR2) from Homo sapiens, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR2) from Rattus norvegicus, and aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AKR7A5/AFAR) from Mus musculus, are founding members of aldo-keto reductase family 7 member A1-5 (AKR7A1-5), respectively. AKR7A2 (EC 1.1.1.n11), also called AFB1 aldehyde reductase 1, or AFB1-AR 1, or aldoketoreductase 7, or succinic semialdehyde reductase, or SSA reductase, catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate (GHB). It has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). AKR7A2, AKR7A3 (also called AFB1 aldehyde reductase 2 or AFB1-AR 2), and AKR7A4 (also called AFB1 aldehyde reductase 3, or AFB1-AR 3, or aldoketoreductase 7-like), may be involved in protection of liver against the toxic and carcinogenic effects of aflatoxin B1 (AFB1), a potent hepatocarcinogen. They can reduce the dialdehyde protein-binding form of AFB1 to the non-binding AFB1 dialcohol.
Pssm-ID: 381301 [Multi-domain] Cd Length: 304 Bit Score: 54.48 E-value: 2.27e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 45 DEGYRHIDGAYVY-HNEHEvgeairEKIAEGKVKREEIFYCGK---LWNTEHVPSMVLPALERTLKALKLDYIDLYIIEL 120
Cdd:cd19075 31 ERGHTEIDTARVYpDGTSE------ELLGELGLGERGFKIDTKanpGVGGGLSPENVRKQLETSLKRLKVDKVDVFYLHA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 121 PmafkpgkeiyprDENGRIIydktnlcatwEALEACKD---AGLVKSLGVSNFNRRQLELILN--------KP----GLk 185
Cdd:cd19075 105 P------------DRSTPLE----------ETLAAIDElykEGKFKEFGLSNYSAWEVAEIVEickengwvLPtvyqGM- 161
|
170 180 190
....*....|....*....|....*....|....*..
gi 568941248 186 YKPVTNQVEchpyftqTKLLKFCQQHDIVIVAHSPLG 222
Cdd:cd19075 162 YNAITRQVE-------TELFPCLRKLGIRFYAYSPLA 191
|
|
| AKR_unchar |
cd19097 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
40-219 |
1.21e-07 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381323 [Multi-domain] Cd Length: 267 Bit Score: 52.14 E-value: 1.21e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 40 VKTAIDEGYRHIDGAYVYHNEHEV-GEAIREKiaegkvkrEEIFYCGKL----WNTEHVPSMVLPALERTLKALKLDYID 114
Cdd:cd19097 32 LEYALKAGINTLDTAPAYGDSEKVlGKFLKRL--------DKFKIITKLpplkEDKKEDEAAIEASVEASLKRLKVDSLD 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 115 LYIIELPMAFKPGKEIYprdengriiydktnlcatWEALEACKDAGLVKSLGVSNFNRRQLELILNKPGLKYkpVtnQVE 194
Cdd:cd19097 104 GLLLHNPDDLLKHGGKL------------------VEALLELKKEGLIRKIGVSVYSPEELEKALESFKIDI--I--QLP 161
|
170 180
....*....|....*....|....*...
gi 568941248 195 CHPY---FTQTKLLKFCQQHDIVIVAHS 219
Cdd:cd19097 162 FNILdqrFLKSGLLAKLKKKGIEIHARS 189
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|
| AKR_AKR12A1_B1_C1 |
cd19087 |
AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, ... |
41-222 |
3.19e-07 |
|
AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, Saccharopolyspora erythraea EryBII, and Streptomyces avermitilis aveBVIII are founding members of aldo-keto reductase family 12 member A1 (AKR12A1), B1 (AKR12B1), and C1(AKR12C1), respectively. TylCII acts as a NDP-hexose 2,3-enoyl reductase. EryBII is a mycarose/desosamine reductase involved in L-mycarose and D-desosamine production. aveBVIII functions as a dTDP-4-keto-6-deoxy-L-hexose-2,3-reductase.
Pssm-ID: 381313 [Multi-domain] Cd Length: 310 Bit Score: 51.03 E-value: 3.19e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 41 KTAIDEGYRHIDGAYVY---HNEHEVGEAIREKiaegkvkREEIFYCGKL------WNTEHVPSM--VLPALERTLKALK 109
Cdd:cd19087 37 DRALDAGINFFDTADVYgggRSEEIIGRWIAGR-------RDDIVLATKVfgpmgdDPNDRGLSRrhIRRAVEASLRRLQ 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 110 LDYIDLYIIELPMAFKPGKEiyprdengriiydktnlcaTWEALEACKDAGLVKSLGVSNF-------------NRRQLE 176
Cdd:cd19087 110 TDYIDLYQMHHFDRDTPLEE-------------------TLRALDDLVRQGKIRYIGVSNFaawqiakaqgiaaRRGLLR 170
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 568941248 177 LILNKPglKYKPVTNQVECHpyftqtkLLKFCQQHDIVIVAHSPLG 222
Cdd:cd19087 171 FVSEQP--MYNLLKRQAELE-------ILPAARAYGLGVIPYSPLA 207
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|
| AKR_galDH |
cd19163 |
L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called ... |
39-296 |
1.74e-06 |
|
L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+).
Pssm-ID: 381389 [Multi-domain] Cd Length: 293 Bit Score: 48.70 E-value: 1.74e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 39 AVKTAIDEGYRHIDGAYVY---HNEHEVGEAIRekiaegKVKREEIFY---CGKLwnTEHVPSM-------VLPALERTL 105
Cdd:cd19163 38 TVHEALDSGINYIDTAPWYgqgRSETVLGKALK------GIPRDSYYLatkVGRY--GLDPDKMfdfsaerITKSVEESL 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 106 KALKLDYIDlyIIEL-PMAFKPGKEIyprdengrIIYDktnlcaTWEALEACKDAGLVKSLGVSNFNRRQLELILNKpgl 184
Cdd:cd19163 110 KRLGLDYID--IIQVhDIEFAPSLDQ--------ILNE------TLPALQKLKEEGKVRFIGITGYPLDVLKEVLER--- 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 185 kykpVTNQVE-----CHpYFTQ----TKLLKFCQQHDIVIVAHSPLG----TCRN-PSWvNVSSPPLLND-ELLTSLGKK 249
Cdd:cd19163 171 ----SPVKIDtvlsyCH-YTLNdtslLELLPFFKEKGVGVINASPLSmgllTERGpPDW-HPASPEIKEAcAKAAAYCKS 244
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 568941248 250 YNKTQAQIVLRFNIQ--RGIVVIPKSFTPERIKENFQIFDFSLTEEEMK 296
Cdd:cd19163 245 RGVDISKLALQFALSnpDIATTLVGTASPENLRKNLEAAEEPLDAHLLA 293
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|
| AKR_unchar |
cd19104 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
9-168 |
5.42e-06 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381330 [Multi-domain] Cd Length: 321 Bit Score: 47.26 E-value: 5.42e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 9 QISLSDGNNIPLIGLGTYSDPRpvpgktyVAVKTAIDEGYRHIDGAYVY---HNEHEVGEAIREKiaegkvkREEIFYCG 85
Cdd:cd19104 14 ELTFGGGGIGGLMGRTTREEQI-------AAVRRALDLGINFFDTAPSYgdgKSEENLGRALKGL-------PAGPYITT 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 86 K----LWNTEHVPSMVLPALERTLKALKLDYIDLYIIE---LPMAFKPGKEIYPRDEngriiYDKTNlcATWEALEACKD 158
Cdd:cd19104 80 KvrldPDDLGDIGGQIERSVEKSLKRLKRDSVDLLQLHnriGDERDKPVGGTLSTTD-----VLGLG--GVADAFERLRS 152
|
170
....*....|
gi 568941248 159 AGLVKSLGVS 168
Cdd:cd19104 153 EGKIRFIGIT 162
|
|
| AKR_AKR13D1 |
cd19145 |
AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of ... |
13-298 |
9.23e-06 |
|
AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.
Pssm-ID: 381371 [Multi-domain] Cd Length: 304 Bit Score: 46.66 E-value: 9.23e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 13 SDGNNIPLIGLG----TYSDPRPVPGKTYVAV-KTAIDEGYRHIDGAYVY---HNEHEVGEAIREKIAEgKVKREEIFYC 84
Cdd:cd19145 7 SQGLEVSAQGLGcmglSGDYGAPKPEEEGIALiHHAFNSGVTFLDTSDIYgpnTNEVLLGKALKDGPRE-KVQLATKFGI 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 85 ----GKLWNTEHVPSMVLPALERTLKALKLDYIDLYI---------IELPMAfkpgkEIYPRDENGRIIYDKTNlcatwe 151
Cdd:cd19145 86 heigGSGVEVRGDPAYVRAACEASLKRLDVDYIDLYYqhridttvpIEITMG-----ELKKLVEEGKIKYIGLS------ 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 152 alEACKDAgLVKSLGVSNFNRRQLELILnkpglkykpVTNQVEchpyftqTKLLKFCQQHDIVIVAHSPLG--------- 222
Cdd:cd19145 155 --EASADT-IRRAHAVHPITAVQLEWSL---------WTRDIE-------EEIIPTCRELGIGIVPYSPLGrgffagkak 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 223 TCRNP--SWVNVSSPPLLNDEL---------LTSLGKKYNKTQAQIVLRFNIQRG--IVVIPKSFTPERIKENFQIFDFS 289
Cdd:cd19145 216 LEELLenSDVRKSHPRFQGENLeknkvlyerVEALAKKKGCTPAQLALAWVLHQGedVVPIPGTTKIKNLNQNIGALSVK 295
|
....*....
gi 568941248 290 LTEEEMKDI 298
Cdd:cd19145 296 LTKEDLKEI 304
|
|
| AKR_AKR10A1_2 |
cd19082 |
AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) ... |
51-169 |
2.96e-05 |
|
AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) and Streptomyces glaucescens aldo-keto reductase (StrT) are founding members of aldo-keto reductase family 10 member A1 (AKR10A1) and A2 (AKR10A2). BlmT is bluensomycin aldo-keto reductase (AKR) and StrT is streptomycin AKR.
Pssm-ID: 381308 [Multi-domain] Cd Length: 291 Bit Score: 44.85 E-value: 2.96e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 51 IDGAYVYHNEHEVG---EAIREKIAEGKvKREEIFYCGK----LWNTEHVPSM----VLPALERTLKALKLDYIDLYIIE 119
Cdd:cd19082 34 IDTARVYGDWVERGaseRVIGEWLKSRG-NRDKVVIATKgghpDLEDMSRSRLspedIRADLEESLERLGTDYIDLYFLH 112
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 568941248 120 lpmafkpgkeiypRDENGR----IIydktnlcatwEALEACKDAGLVKSLGVSN 169
Cdd:cd19082 113 -------------RDDPSVpvgeIV----------DTLNELVRAGKIRAFGASN 143
|
|
| tas |
PRK10625 |
putative aldo-keto reductase; Provisional |
100-307 |
3.44e-05 |
|
putative aldo-keto reductase; Provisional
Pssm-ID: 236727 [Multi-domain] Cd Length: 346 Bit Score: 44.84 E-value: 3.44e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 100 ALERTLKALKLDYIDLYIIELPMafkpgkeiypRDEN--GRIIYDKTN------LCATWEALEACKDAGLVKSLGVSNFN 171
Cdd:PRK10625 113 ALHDSLKRLQTDYLDLYQVHWPQ----------RPTNcfGKLGYSWTDsapavsLLETLDALAEQQRAGKIRYIGVSNET 182
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 172 ----RRQLELIlNKPGLKyKPVTNQvecHPYFT-----QTKLLKFCQQHDIVIVAHSPL--GTCRNpSWVNVSSPPLLND 240
Cdd:PRK10625 183 afgvMRYLHLA-EKHDLP-RIVTIQ---NPYSLlnrsfEVGLAEVSQYEGVELLAYSCLafGTLTG-KYLNGAKPAGARN 256
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 241 ELLT------------------SLGKKYNKTQAQIVLRFNIQRGIV--VIPKSFTPERIKENFQIFDFSLTEEEMKDIDA 300
Cdd:PRK10625 257 TLFSrftrysgeqtqkavaayvDIAKRHGLDPAQMALAFVRRQPFVasTLLGATTMEQLKTNIESLHLTLSEEVLAEIEA 336
|
....*..
gi 568941248 301 LNKNVRY 307
Cdd:PRK10625 337 VHQVYTY 343
|
|
| AKR_unchar |
cd19752 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
94-282 |
7.90e-04 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381391 [Multi-domain] Cd Length: 291 Bit Score: 40.39 E-value: 7.90e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 94 PSMVLPALERTLKALKLDYIDLYIIelpmafkpgkEIYPRDengriiydkTNLCATWEALEACKDAGLVKSLGVSNFNRR 173
Cdd:cd19752 94 AETIEQEIDKSLRRLGTDYIDLYYA----------HVDDRD---------TPLEETLEAFNELVKAGKVRAIGASNFAAW 154
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941248 174 QLEL---ILNKPGL-KYKPVTNQvecHPYF-------------TQTKLLKFCQQH-DIVIVAHSP-LGTCRNPSWVNVSS 234
Cdd:cd19752 155 RLERarqIARQQGWaEFSAIQQR---HSYLrprpgadfgvqriVTDELLDYASSRpDLTLLAYSPlLSGAYTRPDRPLPE 231
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 568941248 235 PPLLND-----ELLTSLGKKYNKTQAQIVLRFNIQRGIVVIP--KSFTPERIKEN 282
Cdd:cd19752 232 QYDGPDsdarlAVLEEVAGELGATPNQVVLAWLLHRTPAIIPllGASTVEQLEEN 286
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| |
