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Conserved domains on  [gi|568939283|ref|XP_006504990|]
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protein furry homolog isoform X3 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Fry_C pfam19421
Furry protein C-terminal; This is the C-terminal domain of Furry (Fry) protein. Fry plays a ...
 2372-3071 0e+00

Furry protein C-terminal; This is the C-terminal domain of Furry (Fry) protein. Fry plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity. This domain binds to polo-like kinase 1 (Plk1) through the polo-box domain (PBD) of Plk1 in a manner dependent on the cyclin-dependent kinase 1-mediated Fry phosphorylation, promoting Plk1 activity during early mitosis. Fry also binds to Aurora A and may function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation.


:

Pssm-ID: 466072  Cd Length: 633  Bit Score: 1214.99  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283  2372 ASKELPGKTLDFHFDISETPIIGRRYDELQNSSGRDGKPRAMAVTRSASSTSSGSNSNVLVPVSWKRPQYSQKRTKEKLV 2451
Cdd:pfam19421    1 SSKELPGKTLDFHFDISETPIIGRRYDELHGSAGRDGKPRVIAVTRSTSSTSSGSNSNVLVPVSWKRPQLSQKRTREKLV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283  2452 HVLSLCGQEVGLSKNPSVIFSSCGDLDLPEHQTSLVSSEDGPREQENMDDTNSEQQFRVFRDFDFLDVELEDGEGESMDN 2531
Cdd:pfam19421   81 NVLSLCGQEVGLTKNPSVIFSSCGDLDLMDQQTSLVSSEDGIREEENMDDTTSEQQFRVFRDFDFLDVELEDGEGESMDN 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283  2532 FNWGVRRRSLDSLDKCDMQILEERQLSRSTPSLNKMSHE-DSDESSEEDLTASQILEHSDLIMNLSPSEEANPMELLTSA 2610
Cdd:pfam19421  161 FNWGVRRRSLDSLDKGDTPSLEESQLSGSTPSLNLTNHEdSDESSEEESLTASQILSHSQLLNSDSPTEEPNHVDSLSQS 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283  2611 CDSAPADPHSFNTRMANFEASLPDINNLQisegskaeavpeeedttvheddlsssinelpaafecsdsfsldmteaeekg 2690
Cdd:pfam19421  241 QDSSSADEESLRAETPSLEVSLPEDASAR--------------------------------------------------- 269

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283  2691 nrgldqytlasfGEGDRGVSPPPSPFFSAILAAFQPAACDDAEEAWRSHINQLMCDSDGSCAVYTFHVFSSLFKNIQKRF 2770
Cdd:pfam19421  270 ------------GFPEIQSSPPPSPFFSAILAAFQPVVCDDAEEAWRCHVNQLVSDSDGSCAVYTFHVFSSLFQNIQRKF 337

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283  2771 CFLTCDAASYLGDNLRGIGSKFVSSSQMLTSCSECPTLFVDAETLLSCGLLDKLKFSVLELQEYLDTYNNRKEATLSWLA 2850
Cdd:pfam19421  338 CSLTCDAVSYLGDSLRGIGSKFLSSSQMLTSCSECPTLFVDAETLMSCGLLEKLKFSVLELQEYLDTYNNKKEAAESWLD 417

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283  2851 NCKATFAGGSRDGVITCQPGDSEEKqmeslaQLELCQRLYKLHFQLLLLYQSYCKLIGQVHEVSSVPELLNMSRELSDLK 2930
Cdd:pfam19421  418 NCKATFPRGSGDGVITCQPADQEEK------QLELCQRLYKLHFQLLLLFQSYCKLIGQVHAISSVPELINMSEELAQLE 491

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283  2931 RNLKEATAAIATDPLYIEG-AWSEPTFTSTEAAIQSMLECLKNNELGKALRQIKECRSLWPNDIFGSSSDDEVQTLLNIY 3009
Cdd:pfam19421  492 SSLKEAEASVTSDELAQEEsASSEPSFSSSEAAVQSILESLRNKEFSTAIRQIKECRSLWPNDIFGSSSEDEVQTLLNIY 571

                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568939283  3010 FRHQTLGQTGTYALVGSNHSLTEICTKLMELNMEIRDMIRRAQNYRVLTAFLPDSSVSGTSL 3071
Cdd:pfam19421  572 FRHQTLGQTGTFALVGSNQDLSEICSKLMELNLEIRDMIRRAQGYRALTAFLPDSSVSGSSL 633
MOR2-PAG1_N pfam14222
Cell morphogenesis N-terminal; This family is the conserved N-terminal region of proteins that ...
 210-716 0e+00

Cell morphogenesis N-terminal; This family is the conserved N-terminal region of proteins that are involved in cell morphogenesis.


:

Pssm-ID: 464107  Cd Length: 554  Bit Score: 619.21  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283   210 ERRDLAIDFIFSLVLIEVLKQIPLHPVIDSLIHDIINLAFKHFKYKEGYLGPNTGNMHIVADLYAEVIGVLAQAKFPAVK 289
Cdd:pfam14222    1 ERKSLASIYILCRVLIEIVKQSPLDALTEELGDKLEEIVFGQLKTADPDQLSSSPNRSANWNLFAELLGVLSEIRFVSVS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283   290 KKFMAELKELRHKEQSPYVVQSIISLIMGMKFFRIKMYPVEDFEASLQFMQECAHYFLEVKDKDIKHALAGLFVEILVPV 369
Cdd:pfam14222   81 DRFIAELEKLPKGLSSKDLEAKIELLIRGMRYLRIKVYPEEAFEESADFMQSLAKFFLNAHGQRVKHAYAEVLVELLLPV 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283   370 AAAVKNEVNVPCLRNFVESLYDTTLELSSRKKHSLALYPLVTCLLCVSQKQLFLNRWHVFLNNCLSNLKNKdpKMARVAL 449
Cdd:pfam14222  161 AATATAEVNHPKWKEAVELLYPRAAKMASKPRHWNVAFPLVTTLLCVSPKEFFLSNWLSLIESLISKLKDK--TTRPVAL 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283   450 ESLYRLLWVYMIRIKcESNTATQSRLITITTTLFPKGSRGVVPRDMPLNIFVKIIQFIAQERLDFAMKEIIFDFLCVGKP 529
Cdd:pfam14222  239 QGLSRLLWVYLYRCT-ESLNTTTRKLESILKLLFPPGKKTWLPADPPLDPLVQIIRFIGFKHPDFCFENIIFPLLNADLF 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283   530 --AKAFSLNPERMNIGLRAFLVIADSLQQKDGEPPMPVTGAVLPSGN--TLRVKKTYLSKTlTEEEAKMIGMSLYYSQVR 605
Cdd:pfam14222  318 ngLKLENLNPERMIIGIRAFLAILSDLEKGEQRPPFPQSFGTLPSPSssALRSKEENLSRP-VDTLALSEGIKDYYERFC 396

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283   606 KAVGNILRHLDKEVGRCMML-------------TNVQMLNKEPED-MITGERKPKIDLFRTCVAAIPRLLPDGMSKLELI 671
Cdd:pfam14222  397 KILGKILILCDNTFGGQAVLdekfssptpktpiSETFNFSRRPDDnAYDGQRQPFYELLHTAVQAIPRCLPSSIPFNSLI 476

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*
gi 568939283   672 DLLARLSIHMDDELRHIAQNSLQGLLVdfSDWREDVLFGFTNFLL 716
Cdd:pfam14222  477 ELLCRGTVHVDPNIAESAAQALKRIAR--PSHAQQVITGFARFIF 519
MOR2-PAG1_C pfam14225
Cell morphogenesis C-terminal; This family is the conserved C-terminal region of proteins that ...
 2095-2348 3.31e-62

Cell morphogenesis C-terminal; This family is the conserved C-terminal region of proteins that are involved in cell morphogenesis.


:

Pssm-ID: 464109  Cd Length: 252  Bit Score: 213.88  E-value: 3.31e-62
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283  2095 ATIFWVTVALMESDFEFEYLMALRLLNRLLAHMPLEKAENREKLEKLQAQlKW-ADFPGLQQLLLKGFTSLTTTDLTLQL 2173
Cdd:pfam14225    1 PQLFWTTVACLETIHEHEFLEALRLLEKLLDKLDLDDPDVVEKLLSSQPQ-KWeGKFEGLQPLLLKGLRSSVTLEPTLKL 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283  2174 FSLLTSVSKVPMVDSSQAiGFPLNVLCLLPQLIQHFENP--NQFCKDIAERIAQVCLEEKnpkLSNLAHVMTLYKTHSYt 2251
Cdd:pfam14225   80 LDRLTKLPDDRLVGPSDS-RLLFLVLANLPRFLHALDDPdiDPDCIETAENLAELAEEQG---LPSLARVLTSYAKGRF- 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283  2252 RDCATWVNVVCRYLHEAYADITLN-MVTYLAELLEKGLPSMQQPLLQVIYSLLSYMDLSVVPVKQFNMEVLKTIEKYVQS 2330
Cdd:pfam14225  155 RTSDDFLKQVVSYLREAYFPDYEFqMLTFLLGLLTNGPPWVKVKTLQILKVLLPEIDMRRPEIAGHGADLISPLLRLLQT 234

                          250
                   ....*....|....*...
gi 568939283  2331 IHWREALNILKLVVSRSA 2348
Cdd:pfam14225  235 DLCMQALEVLDEIVTISG 252
MOR2-PAG1_mid super family cl20509
Cell morphogenesis central region; This family is the conserved central region of proteins ...
 779-1943 2.23e-25

Cell morphogenesis central region; This family is the conserved central region of proteins that are involved in cell morphogenesis.


The actual alignment was detected with superfamily member pfam14228:

Pssm-ID: 433790 [Multi-domain]  Cd Length: 1113  Bit Score: 115.89  E-value: 2.23e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283   779 HCSVLHAVegfALVLLCSFQVATRKLSVLILKEIRALF-----LALGQPED-----DDRP--MIDVMDQLSSSILESfih 846
Cdd:pfam14228    5 RPSGLDAV---GLIFLSSVDVQIRHTALELLRCVRALYndlrdMSSKERSDvswknNKEPifIIDVFEENGDDIVQQ--- 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283   847 vAVSDSAtlpptHNVDLQwlVEWNAVlvnshydvksPSHVW---IFAQSVKDPWVLCLFSFLRQENlpKHCPTALSYAwp 923
Cdd:pfam14228   79 -CYWDSG-----RPYDMR--RESDAI----------PPDLTlqsILESPDKGRWARCLSELVKYAA--ELCPSSVQEA-- 136

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283   924 yaftRLQSVMPLVDPNSPVNAKKTSTASSGDNYVTLWRNYLIlcFGVAKPsimspghlrastpeimattPDgtvsyDNKA 1003
Cdd:pfam14228  137 ----RLEVVQRLAQITPVELGGKAHQSQDADNKLDQWLLYSM--FACSCP-------------------PD-----DVED 186

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283  1004 IGTPSVGVLLKQLVPLMRLESIEITESLVLGFGRTNSLVFRELVEELHPLMKEA---LERRPENKKRRERRDLLRLQLLR 1080
Cdd:pfam14228  187 TKSHSAKELYHLIFPSLKSGSETHIHAATLALGHSHLEVCEPMFGELRSFLDEVateTESKPKWKSQKARREELRVHVAN 266

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283  1081 IFELLADagvisDSTNGALERDTLaLGALFLEYV-DLTRMLLEA--ENDKEVEILKDIRAhfSAMVANLIQCVPVHHRRF 1157
Cdd:pfam14228  267 IYRMVAE-----NFWPGMLIRKPV-FRLHVLKFIeDTVRYITTSplENFQDLQPLRFALA--SVLRSLAPEFVKSKSERF 338

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283  1158 lfpQQSLRHHLFILFSQWAGPFSIMFTPlDRYSDRNHQITRY----------------------------QYCALKAMSA 1209
Cdd:pfam14228  339 ---DPRTRKRLFDLLASWCDDTGTVWSQ-DGVSDYRREVERYkssqnsrskdsvdkisfdkevneqveaiQWIAMNAMAA 414

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283  1210 VLCcGPVFDNVGLSPDGYLYKWLDNI--------------------------------LACQD------LRVHqLGCEVV 1251
Cdd:pfam14228  415 LLY-GPCFDDNARKMSGRVIAWINGLflepaprapfgyspadprtpsyskfagegvrgLGGKDrhrggpLRVH-LAKVAL 492

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283  1252 MLLLELNPDqinLFNWAIDRCYTGSYQLASGCFKAIATVCGNRNYP-FDIVTLLNLVLFKASDTNREIYEVSMQLMQILE 1330
Cdd:pfam14228  493 KNLLQTNLD---LFPACIDQCYSSDASIADGYFSVLAEVYMRQEIPrCDIQRLLSLILYKVVDPSRRIRDDALQMLETLS 569

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283  1331 AKLFVHSkkvAEQRPGSILYGTHGPLPPLYSVSLALLSCELARMYPELTLPLFSEVSQR-FPTTHPNGRQIMLTYLLPWL 1409
Cdd:pfam14228  570 VREWAED---GEEGTGRYRAAVVGNLPDSYQQFQYKLSAKLAKDHPELSELLCEEIMQRqLDAVDIIAQHQVLTCMAPWI 646

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283  1410 HNIELVdsrlllpgsspsspedevkdregevtashGLKGNGWgspeaTSLVLNNLMYMTAKYGDEVPGaEMENAWNALAN 1489
Cdd:pfam14228  647 ENLNFL-----------------------------KLWESGW-----SERLLKSLYYVTWRHGDQFPD-EIEKLWRTIAS 691

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283  1490 NEKwsnNLRVTLQFLISLCGVSSDT--------ILLPYI---KKVATYLCRNNTIQTMEELLFELQQ------TEPVNPi 1552
Cdd:pfam14228  692 KPR---NISPVLDFLISKGIEDCDSnasaeitgAFATYFsvaKRVSLYLARICPQQTIDHLVYELAQrmleesVEPSRP- 767

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283  1553 vqhcdnppfyrftasskasAAASGTTSSSNTVVAGQDsfPDPEESKILKESDDRFSNVIrAHTRLESRYSNSSGG----- 1627
Cdd:pfam14228  768 -------------------SDGAFDLESSAVLEFSQG--PAPVQVAQLLDPQPHMSPLL-VRSSLEGPLRNASGSlswrt 825

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283  1628 SYDEDKNDPISPYTGWLLSITEAKQ-----PQPLPMPCSGGcwaPLV-------------------DYLPET-------- 1675
Cdd:pfam14228  826 VTGRSMSGPLNTMPEVVAVDTHTGRsgqlfTGSGPLPNMSG---PLMgvrsstgslrshhvsrdsgDYFIDTpnsveeir 902

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283  1676 ITP-----------RGPLH---RCNIAVIFMTEMVVDHSvrEDWALHLPLLLHAVFLGLDHYRPEVFEHSKklllhllia 1741
Cdd:pfam14228  903 ITPvvnaselqsalQGHQHwlsRADIALILLAEIAYEND--EDFRSHLPLLFHVTFVSMDSSEDIVLKHCQ--------- 971

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283  1742 lscnsnfHAIASVL--LQTREMgeaktltmqpayqpeylytggfdflredqsspvpdsglnssstsssislggssgnlpq 1819
Cdd:pfam14228  972 -------HLLVNLLysLAGRHL---------------------------------------------------------- 986

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283  1820 mtqEVEDVEAAT-ETDEKASKLIEFLTTRAFGPLWCHEDITPKNQNSKSAEQLSNFLRHVVS--VFKDSrsgfhLEQHLS 1896
Cdd:pfam14228  987 ---ELYDVEHGDgEYKQQVVSLIKYVQSKRGSRMWENEDMTLTRTELPSAALLSALVLSMVDaiFFQGD-----LREKWG 1058

                         1290      1300      1310      1320
                   ....*....|....*....|....*....|....*....|....*..
gi 568939283  1897 EVALQTALASSSRHYAGRSFQIFRALKQPLSAHALSDLLSRLVEVIG 1943
Cdd:pfam14228 1059 EEALKWAMECTSRHLACRSHQIYRALRPSVTSDTCVSLLRCLHRCLG 1105
 
Name Accession Description Interval E-value
Fry_C pfam19421
Furry protein C-terminal; This is the C-terminal domain of Furry (Fry) protein. Fry plays a ...
 2372-3071 0e+00

Furry protein C-terminal; This is the C-terminal domain of Furry (Fry) protein. Fry plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity. This domain binds to polo-like kinase 1 (Plk1) through the polo-box domain (PBD) of Plk1 in a manner dependent on the cyclin-dependent kinase 1-mediated Fry phosphorylation, promoting Plk1 activity during early mitosis. Fry also binds to Aurora A and may function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation.


Pssm-ID: 466072  Cd Length: 633  Bit Score: 1214.99  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283  2372 ASKELPGKTLDFHFDISETPIIGRRYDELQNSSGRDGKPRAMAVTRSASSTSSGSNSNVLVPVSWKRPQYSQKRTKEKLV 2451
Cdd:pfam19421    1 SSKELPGKTLDFHFDISETPIIGRRYDELHGSAGRDGKPRVIAVTRSTSSTSSGSNSNVLVPVSWKRPQLSQKRTREKLV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283  2452 HVLSLCGQEVGLSKNPSVIFSSCGDLDLPEHQTSLVSSEDGPREQENMDDTNSEQQFRVFRDFDFLDVELEDGEGESMDN 2531
Cdd:pfam19421   81 NVLSLCGQEVGLTKNPSVIFSSCGDLDLMDQQTSLVSSEDGIREEENMDDTTSEQQFRVFRDFDFLDVELEDGEGESMDN 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283  2532 FNWGVRRRSLDSLDKCDMQILEERQLSRSTPSLNKMSHE-DSDESSEEDLTASQILEHSDLIMNLSPSEEANPMELLTSA 2610
Cdd:pfam19421  161 FNWGVRRRSLDSLDKGDTPSLEESQLSGSTPSLNLTNHEdSDESSEEESLTASQILSHSQLLNSDSPTEEPNHVDSLSQS 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283  2611 CDSAPADPHSFNTRMANFEASLPDINNLQisegskaeavpeeedttvheddlsssinelpaafecsdsfsldmteaeekg 2690
Cdd:pfam19421  241 QDSSSADEESLRAETPSLEVSLPEDASAR--------------------------------------------------- 269

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283  2691 nrgldqytlasfGEGDRGVSPPPSPFFSAILAAFQPAACDDAEEAWRSHINQLMCDSDGSCAVYTFHVFSSLFKNIQKRF 2770
Cdd:pfam19421  270 ------------GFPEIQSSPPPSPFFSAILAAFQPVVCDDAEEAWRCHVNQLVSDSDGSCAVYTFHVFSSLFQNIQRKF 337

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283  2771 CFLTCDAASYLGDNLRGIGSKFVSSSQMLTSCSECPTLFVDAETLLSCGLLDKLKFSVLELQEYLDTYNNRKEATLSWLA 2850
Cdd:pfam19421  338 CSLTCDAVSYLGDSLRGIGSKFLSSSQMLTSCSECPTLFVDAETLMSCGLLEKLKFSVLELQEYLDTYNNKKEAAESWLD 417

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283  2851 NCKATFAGGSRDGVITCQPGDSEEKqmeslaQLELCQRLYKLHFQLLLLYQSYCKLIGQVHEVSSVPELLNMSRELSDLK 2930
Cdd:pfam19421  418 NCKATFPRGSGDGVITCQPADQEEK------QLELCQRLYKLHFQLLLLFQSYCKLIGQVHAISSVPELINMSEELAQLE 491

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283  2931 RNLKEATAAIATDPLYIEG-AWSEPTFTSTEAAIQSMLECLKNNELGKALRQIKECRSLWPNDIFGSSSDDEVQTLLNIY 3009
Cdd:pfam19421  492 SSLKEAEASVTSDELAQEEsASSEPSFSSSEAAVQSILESLRNKEFSTAIRQIKECRSLWPNDIFGSSSEDEVQTLLNIY 571

                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568939283  3010 FRHQTLGQTGTYALVGSNHSLTEICTKLMELNMEIRDMIRRAQNYRVLTAFLPDSSVSGTSL 3071
Cdd:pfam19421  572 FRHQTLGQTGTFALVGSNQDLSEICSKLMELNLEIRDMIRRAQGYRALTAFLPDSSVSGSSL 633
MOR2-PAG1_N pfam14222
Cell morphogenesis N-terminal; This family is the conserved N-terminal region of proteins that ...
 210-716 0e+00

Cell morphogenesis N-terminal; This family is the conserved N-terminal region of proteins that are involved in cell morphogenesis.


Pssm-ID: 464107  Cd Length: 554  Bit Score: 619.21  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283   210 ERRDLAIDFIFSLVLIEVLKQIPLHPVIDSLIHDIINLAFKHFKYKEGYLGPNTGNMHIVADLYAEVIGVLAQAKFPAVK 289
Cdd:pfam14222    1 ERKSLASIYILCRVLIEIVKQSPLDALTEELGDKLEEIVFGQLKTADPDQLSSSPNRSANWNLFAELLGVLSEIRFVSVS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283   290 KKFMAELKELRHKEQSPYVVQSIISLIMGMKFFRIKMYPVEDFEASLQFMQECAHYFLEVKDKDIKHALAGLFVEILVPV 369
Cdd:pfam14222   81 DRFIAELEKLPKGLSSKDLEAKIELLIRGMRYLRIKVYPEEAFEESADFMQSLAKFFLNAHGQRVKHAYAEVLVELLLPV 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283   370 AAAVKNEVNVPCLRNFVESLYDTTLELSSRKKHSLALYPLVTCLLCVSQKQLFLNRWHVFLNNCLSNLKNKdpKMARVAL 449
Cdd:pfam14222  161 AATATAEVNHPKWKEAVELLYPRAAKMASKPRHWNVAFPLVTTLLCVSPKEFFLSNWLSLIESLISKLKDK--TTRPVAL 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283   450 ESLYRLLWVYMIRIKcESNTATQSRLITITTTLFPKGSRGVVPRDMPLNIFVKIIQFIAQERLDFAMKEIIFDFLCVGKP 529
Cdd:pfam14222  239 QGLSRLLWVYLYRCT-ESLNTTTRKLESILKLLFPPGKKTWLPADPPLDPLVQIIRFIGFKHPDFCFENIIFPLLNADLF 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283   530 --AKAFSLNPERMNIGLRAFLVIADSLQQKDGEPPMPVTGAVLPSGN--TLRVKKTYLSKTlTEEEAKMIGMSLYYSQVR 605
Cdd:pfam14222  318 ngLKLENLNPERMIIGIRAFLAILSDLEKGEQRPPFPQSFGTLPSPSssALRSKEENLSRP-VDTLALSEGIKDYYERFC 396

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283   606 KAVGNILRHLDKEVGRCMML-------------TNVQMLNKEPED-MITGERKPKIDLFRTCVAAIPRLLPDGMSKLELI 671
Cdd:pfam14222  397 KILGKILILCDNTFGGQAVLdekfssptpktpiSETFNFSRRPDDnAYDGQRQPFYELLHTAVQAIPRCLPSSIPFNSLI 476

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*
gi 568939283   672 DLLARLSIHMDDELRHIAQNSLQGLLVdfSDWREDVLFGFTNFLL 716
Cdd:pfam14222  477 ELLCRGTVHVDPNIAESAAQALKRIAR--PSHAQQVITGFARFIF 519
MOR2-PAG1_C pfam14225
Cell morphogenesis C-terminal; This family is the conserved C-terminal region of proteins that ...
 2095-2348 3.31e-62

Cell morphogenesis C-terminal; This family is the conserved C-terminal region of proteins that are involved in cell morphogenesis.


Pssm-ID: 464109  Cd Length: 252  Bit Score: 213.88  E-value: 3.31e-62
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283  2095 ATIFWVTVALMESDFEFEYLMALRLLNRLLAHMPLEKAENREKLEKLQAQlKW-ADFPGLQQLLLKGFTSLTTTDLTLQL 2173
Cdd:pfam14225    1 PQLFWTTVACLETIHEHEFLEALRLLEKLLDKLDLDDPDVVEKLLSSQPQ-KWeGKFEGLQPLLLKGLRSSVTLEPTLKL 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283  2174 FSLLTSVSKVPMVDSSQAiGFPLNVLCLLPQLIQHFENP--NQFCKDIAERIAQVCLEEKnpkLSNLAHVMTLYKTHSYt 2251
Cdd:pfam14225   80 LDRLTKLPDDRLVGPSDS-RLLFLVLANLPRFLHALDDPdiDPDCIETAENLAELAEEQG---LPSLARVLTSYAKGRF- 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283  2252 RDCATWVNVVCRYLHEAYADITLN-MVTYLAELLEKGLPSMQQPLLQVIYSLLSYMDLSVVPVKQFNMEVLKTIEKYVQS 2330
Cdd:pfam14225  155 RTSDDFLKQVVSYLREAYFPDYEFqMLTFLLGLLTNGPPWVKVKTLQILKVLLPEIDMRRPEIAGHGADLISPLLRLLQT 234

                          250
                   ....*....|....*...
gi 568939283  2331 IHWREALNILKLVVSRSA 2348
Cdd:pfam14225  235 DLCMQALEVLDEIVTISG 252
MOR2-PAG1_mid pfam14228
Cell morphogenesis central region; This family is the conserved central region of proteins ...
 779-1943 2.23e-25

Cell morphogenesis central region; This family is the conserved central region of proteins that are involved in cell morphogenesis.


Pssm-ID: 433790 [Multi-domain]  Cd Length: 1113  Bit Score: 115.89  E-value: 2.23e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283   779 HCSVLHAVegfALVLLCSFQVATRKLSVLILKEIRALF-----LALGQPED-----DDRP--MIDVMDQLSSSILESfih 846
Cdd:pfam14228    5 RPSGLDAV---GLIFLSSVDVQIRHTALELLRCVRALYndlrdMSSKERSDvswknNKEPifIIDVFEENGDDIVQQ--- 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283   847 vAVSDSAtlpptHNVDLQwlVEWNAVlvnshydvksPSHVW---IFAQSVKDPWVLCLFSFLRQENlpKHCPTALSYAwp 923
Cdd:pfam14228   79 -CYWDSG-----RPYDMR--RESDAI----------PPDLTlqsILESPDKGRWARCLSELVKYAA--ELCPSSVQEA-- 136

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283   924 yaftRLQSVMPLVDPNSPVNAKKTSTASSGDNYVTLWRNYLIlcFGVAKPsimspghlrastpeimattPDgtvsyDNKA 1003
Cdd:pfam14228  137 ----RLEVVQRLAQITPVELGGKAHQSQDADNKLDQWLLYSM--FACSCP-------------------PD-----DVED 186

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283  1004 IGTPSVGVLLKQLVPLMRLESIEITESLVLGFGRTNSLVFRELVEELHPLMKEA---LERRPENKKRRERRDLLRLQLLR 1080
Cdd:pfam14228  187 TKSHSAKELYHLIFPSLKSGSETHIHAATLALGHSHLEVCEPMFGELRSFLDEVateTESKPKWKSQKARREELRVHVAN 266

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283  1081 IFELLADagvisDSTNGALERDTLaLGALFLEYV-DLTRMLLEA--ENDKEVEILKDIRAhfSAMVANLIQCVPVHHRRF 1157
Cdd:pfam14228  267 IYRMVAE-----NFWPGMLIRKPV-FRLHVLKFIeDTVRYITTSplENFQDLQPLRFALA--SVLRSLAPEFVKSKSERF 338

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283  1158 lfpQQSLRHHLFILFSQWAGPFSIMFTPlDRYSDRNHQITRY----------------------------QYCALKAMSA 1209
Cdd:pfam14228  339 ---DPRTRKRLFDLLASWCDDTGTVWSQ-DGVSDYRREVERYkssqnsrskdsvdkisfdkevneqveaiQWIAMNAMAA 414

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283  1210 VLCcGPVFDNVGLSPDGYLYKWLDNI--------------------------------LACQD------LRVHqLGCEVV 1251
Cdd:pfam14228  415 LLY-GPCFDDNARKMSGRVIAWINGLflepaprapfgyspadprtpsyskfagegvrgLGGKDrhrggpLRVH-LAKVAL 492

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283  1252 MLLLELNPDqinLFNWAIDRCYTGSYQLASGCFKAIATVCGNRNYP-FDIVTLLNLVLFKASDTNREIYEVSMQLMQILE 1330
Cdd:pfam14228  493 KNLLQTNLD---LFPACIDQCYSSDASIADGYFSVLAEVYMRQEIPrCDIQRLLSLILYKVVDPSRRIRDDALQMLETLS 569

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283  1331 AKLFVHSkkvAEQRPGSILYGTHGPLPPLYSVSLALLSCELARMYPELTLPLFSEVSQR-FPTTHPNGRQIMLTYLLPWL 1409
Cdd:pfam14228  570 VREWAED---GEEGTGRYRAAVVGNLPDSYQQFQYKLSAKLAKDHPELSELLCEEIMQRqLDAVDIIAQHQVLTCMAPWI 646

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283  1410 HNIELVdsrlllpgsspsspedevkdregevtashGLKGNGWgspeaTSLVLNNLMYMTAKYGDEVPGaEMENAWNALAN 1489
Cdd:pfam14228  647 ENLNFL-----------------------------KLWESGW-----SERLLKSLYYVTWRHGDQFPD-EIEKLWRTIAS 691

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283  1490 NEKwsnNLRVTLQFLISLCGVSSDT--------ILLPYI---KKVATYLCRNNTIQTMEELLFELQQ------TEPVNPi 1552
Cdd:pfam14228  692 KPR---NISPVLDFLISKGIEDCDSnasaeitgAFATYFsvaKRVSLYLARICPQQTIDHLVYELAQrmleesVEPSRP- 767

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283  1553 vqhcdnppfyrftasskasAAASGTTSSSNTVVAGQDsfPDPEESKILKESDDRFSNVIrAHTRLESRYSNSSGG----- 1627
Cdd:pfam14228  768 -------------------SDGAFDLESSAVLEFSQG--PAPVQVAQLLDPQPHMSPLL-VRSSLEGPLRNASGSlswrt 825

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283  1628 SYDEDKNDPISPYTGWLLSITEAKQ-----PQPLPMPCSGGcwaPLV-------------------DYLPET-------- 1675
Cdd:pfam14228  826 VTGRSMSGPLNTMPEVVAVDTHTGRsgqlfTGSGPLPNMSG---PLMgvrsstgslrshhvsrdsgDYFIDTpnsveeir 902

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283  1676 ITP-----------RGPLH---RCNIAVIFMTEMVVDHSvrEDWALHLPLLLHAVFLGLDHYRPEVFEHSKklllhllia 1741
Cdd:pfam14228  903 ITPvvnaselqsalQGHQHwlsRADIALILLAEIAYEND--EDFRSHLPLLFHVTFVSMDSSEDIVLKHCQ--------- 971

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283  1742 lscnsnfHAIASVL--LQTREMgeaktltmqpayqpeylytggfdflredqsspvpdsglnssstsssislggssgnlpq 1819
Cdd:pfam14228  972 -------HLLVNLLysLAGRHL---------------------------------------------------------- 986

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283  1820 mtqEVEDVEAAT-ETDEKASKLIEFLTTRAFGPLWCHEDITPKNQNSKSAEQLSNFLRHVVS--VFKDSrsgfhLEQHLS 1896
Cdd:pfam14228  987 ---ELYDVEHGDgEYKQQVVSLIKYVQSKRGSRMWENEDMTLTRTELPSAALLSALVLSMVDaiFFQGD-----LREKWG 1058

                         1290      1300      1310      1320
                   ....*....|....*....|....*....|....*....|....*..
gi 568939283  1897 EVALQTALASSSRHYAGRSFQIFRALKQPLSAHALSDLLSRLVEVIG 1943
Cdd:pfam14228 1059 EEALKWAMECTSRHLACRSHQIYRALRPSVTSDTCVSLLRCLHRCLG 1105
 
Name Accession Description Interval E-value
Fry_C pfam19421
Furry protein C-terminal; This is the C-terminal domain of Furry (Fry) protein. Fry plays a ...
 2372-3071 0e+00

Furry protein C-terminal; This is the C-terminal domain of Furry (Fry) protein. Fry plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity. This domain binds to polo-like kinase 1 (Plk1) through the polo-box domain (PBD) of Plk1 in a manner dependent on the cyclin-dependent kinase 1-mediated Fry phosphorylation, promoting Plk1 activity during early mitosis. Fry also binds to Aurora A and may function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation.


Pssm-ID: 466072  Cd Length: 633  Bit Score: 1214.99  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283  2372 ASKELPGKTLDFHFDISETPIIGRRYDELQNSSGRDGKPRAMAVTRSASSTSSGSNSNVLVPVSWKRPQYSQKRTKEKLV 2451
Cdd:pfam19421    1 SSKELPGKTLDFHFDISETPIIGRRYDELHGSAGRDGKPRVIAVTRSTSSTSSGSNSNVLVPVSWKRPQLSQKRTREKLV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283  2452 HVLSLCGQEVGLSKNPSVIFSSCGDLDLPEHQTSLVSSEDGPREQENMDDTNSEQQFRVFRDFDFLDVELEDGEGESMDN 2531
Cdd:pfam19421   81 NVLSLCGQEVGLTKNPSVIFSSCGDLDLMDQQTSLVSSEDGIREEENMDDTTSEQQFRVFRDFDFLDVELEDGEGESMDN 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283  2532 FNWGVRRRSLDSLDKCDMQILEERQLSRSTPSLNKMSHE-DSDESSEEDLTASQILEHSDLIMNLSPSEEANPMELLTSA 2610
Cdd:pfam19421  161 FNWGVRRRSLDSLDKGDTPSLEESQLSGSTPSLNLTNHEdSDESSEEESLTASQILSHSQLLNSDSPTEEPNHVDSLSQS 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283  2611 CDSAPADPHSFNTRMANFEASLPDINNLQisegskaeavpeeedttvheddlsssinelpaafecsdsfsldmteaeekg 2690
Cdd:pfam19421  241 QDSSSADEESLRAETPSLEVSLPEDASAR--------------------------------------------------- 269

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283  2691 nrgldqytlasfGEGDRGVSPPPSPFFSAILAAFQPAACDDAEEAWRSHINQLMCDSDGSCAVYTFHVFSSLFKNIQKRF 2770
Cdd:pfam19421  270 ------------GFPEIQSSPPPSPFFSAILAAFQPVVCDDAEEAWRCHVNQLVSDSDGSCAVYTFHVFSSLFQNIQRKF 337

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283  2771 CFLTCDAASYLGDNLRGIGSKFVSSSQMLTSCSECPTLFVDAETLLSCGLLDKLKFSVLELQEYLDTYNNRKEATLSWLA 2850
Cdd:pfam19421  338 CSLTCDAVSYLGDSLRGIGSKFLSSSQMLTSCSECPTLFVDAETLMSCGLLEKLKFSVLELQEYLDTYNNKKEAAESWLD 417

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283  2851 NCKATFAGGSRDGVITCQPGDSEEKqmeslaQLELCQRLYKLHFQLLLLYQSYCKLIGQVHEVSSVPELLNMSRELSDLK 2930
Cdd:pfam19421  418 NCKATFPRGSGDGVITCQPADQEEK------QLELCQRLYKLHFQLLLLFQSYCKLIGQVHAISSVPELINMSEELAQLE 491

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283  2931 RNLKEATAAIATDPLYIEG-AWSEPTFTSTEAAIQSMLECLKNNELGKALRQIKECRSLWPNDIFGSSSDDEVQTLLNIY 3009
Cdd:pfam19421  492 SSLKEAEASVTSDELAQEEsASSEPSFSSSEAAVQSILESLRNKEFSTAIRQIKECRSLWPNDIFGSSSEDEVQTLLNIY 571

                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568939283  3010 FRHQTLGQTGTYALVGSNHSLTEICTKLMELNMEIRDMIRRAQNYRVLTAFLPDSSVSGTSL 3071
Cdd:pfam19421  572 FRHQTLGQTGTFALVGSNQDLSEICSKLMELNLEIRDMIRRAQGYRALTAFLPDSSVSGSSL 633
MOR2-PAG1_N pfam14222
Cell morphogenesis N-terminal; This family is the conserved N-terminal region of proteins that ...
 210-716 0e+00

Cell morphogenesis N-terminal; This family is the conserved N-terminal region of proteins that are involved in cell morphogenesis.


Pssm-ID: 464107  Cd Length: 554  Bit Score: 619.21  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283   210 ERRDLAIDFIFSLVLIEVLKQIPLHPVIDSLIHDIINLAFKHFKYKEGYLGPNTGNMHIVADLYAEVIGVLAQAKFPAVK 289
Cdd:pfam14222    1 ERKSLASIYILCRVLIEIVKQSPLDALTEELGDKLEEIVFGQLKTADPDQLSSSPNRSANWNLFAELLGVLSEIRFVSVS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283   290 KKFMAELKELRHKEQSPYVVQSIISLIMGMKFFRIKMYPVEDFEASLQFMQECAHYFLEVKDKDIKHALAGLFVEILVPV 369
Cdd:pfam14222   81 DRFIAELEKLPKGLSSKDLEAKIELLIRGMRYLRIKVYPEEAFEESADFMQSLAKFFLNAHGQRVKHAYAEVLVELLLPV 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283   370 AAAVKNEVNVPCLRNFVESLYDTTLELSSRKKHSLALYPLVTCLLCVSQKQLFLNRWHVFLNNCLSNLKNKdpKMARVAL 449
Cdd:pfam14222  161 AATATAEVNHPKWKEAVELLYPRAAKMASKPRHWNVAFPLVTTLLCVSPKEFFLSNWLSLIESLISKLKDK--TTRPVAL 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283   450 ESLYRLLWVYMIRIKcESNTATQSRLITITTTLFPKGSRGVVPRDMPLNIFVKIIQFIAQERLDFAMKEIIFDFLCVGKP 529
Cdd:pfam14222  239 QGLSRLLWVYLYRCT-ESLNTTTRKLESILKLLFPPGKKTWLPADPPLDPLVQIIRFIGFKHPDFCFENIIFPLLNADLF 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283   530 --AKAFSLNPERMNIGLRAFLVIADSLQQKDGEPPMPVTGAVLPSGN--TLRVKKTYLSKTlTEEEAKMIGMSLYYSQVR 605
Cdd:pfam14222  318 ngLKLENLNPERMIIGIRAFLAILSDLEKGEQRPPFPQSFGTLPSPSssALRSKEENLSRP-VDTLALSEGIKDYYERFC 396

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283   606 KAVGNILRHLDKEVGRCMML-------------TNVQMLNKEPED-MITGERKPKIDLFRTCVAAIPRLLPDGMSKLELI 671
Cdd:pfam14222  397 KILGKILILCDNTFGGQAVLdekfssptpktpiSETFNFSRRPDDnAYDGQRQPFYELLHTAVQAIPRCLPSSIPFNSLI 476

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*
gi 568939283   672 DLLARLSIHMDDELRHIAQNSLQGLLVdfSDWREDVLFGFTNFLL 716
Cdd:pfam14222  477 ELLCRGTVHVDPNIAESAAQALKRIAR--PSHAQQVITGFARFIF 519
MOR2-PAG1_C pfam14225
Cell morphogenesis C-terminal; This family is the conserved C-terminal region of proteins that ...
 2095-2348 3.31e-62

Cell morphogenesis C-terminal; This family is the conserved C-terminal region of proteins that are involved in cell morphogenesis.


Pssm-ID: 464109  Cd Length: 252  Bit Score: 213.88  E-value: 3.31e-62
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283  2095 ATIFWVTVALMESDFEFEYLMALRLLNRLLAHMPLEKAENREKLEKLQAQlKW-ADFPGLQQLLLKGFTSLTTTDLTLQL 2173
Cdd:pfam14225    1 PQLFWTTVACLETIHEHEFLEALRLLEKLLDKLDLDDPDVVEKLLSSQPQ-KWeGKFEGLQPLLLKGLRSSVTLEPTLKL 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283  2174 FSLLTSVSKVPMVDSSQAiGFPLNVLCLLPQLIQHFENP--NQFCKDIAERIAQVCLEEKnpkLSNLAHVMTLYKTHSYt 2251
Cdd:pfam14225   80 LDRLTKLPDDRLVGPSDS-RLLFLVLANLPRFLHALDDPdiDPDCIETAENLAELAEEQG---LPSLARVLTSYAKGRF- 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283  2252 RDCATWVNVVCRYLHEAYADITLN-MVTYLAELLEKGLPSMQQPLLQVIYSLLSYMDLSVVPVKQFNMEVLKTIEKYVQS 2330
Cdd:pfam14225  155 RTSDDFLKQVVSYLREAYFPDYEFqMLTFLLGLLTNGPPWVKVKTLQILKVLLPEIDMRRPEIAGHGADLISPLLRLLQT 234

                          250
                   ....*....|....*...
gi 568939283  2331 IHWREALNILKLVVSRSA 2348
Cdd:pfam14225  235 DLCMQALEVLDEIVTISG 252
MOR2-PAG1_mid pfam14228
Cell morphogenesis central region; This family is the conserved central region of proteins ...
 779-1943 2.23e-25

Cell morphogenesis central region; This family is the conserved central region of proteins that are involved in cell morphogenesis.


Pssm-ID: 433790 [Multi-domain]  Cd Length: 1113  Bit Score: 115.89  E-value: 2.23e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283   779 HCSVLHAVegfALVLLCSFQVATRKLSVLILKEIRALF-----LALGQPED-----DDRP--MIDVMDQLSSSILESfih 846
Cdd:pfam14228    5 RPSGLDAV---GLIFLSSVDVQIRHTALELLRCVRALYndlrdMSSKERSDvswknNKEPifIIDVFEENGDDIVQQ--- 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283   847 vAVSDSAtlpptHNVDLQwlVEWNAVlvnshydvksPSHVW---IFAQSVKDPWVLCLFSFLRQENlpKHCPTALSYAwp 923
Cdd:pfam14228   79 -CYWDSG-----RPYDMR--RESDAI----------PPDLTlqsILESPDKGRWARCLSELVKYAA--ELCPSSVQEA-- 136

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283   924 yaftRLQSVMPLVDPNSPVNAKKTSTASSGDNYVTLWRNYLIlcFGVAKPsimspghlrastpeimattPDgtvsyDNKA 1003
Cdd:pfam14228  137 ----RLEVVQRLAQITPVELGGKAHQSQDADNKLDQWLLYSM--FACSCP-------------------PD-----DVED 186

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283  1004 IGTPSVGVLLKQLVPLMRLESIEITESLVLGFGRTNSLVFRELVEELHPLMKEA---LERRPENKKRRERRDLLRLQLLR 1080
Cdd:pfam14228  187 TKSHSAKELYHLIFPSLKSGSETHIHAATLALGHSHLEVCEPMFGELRSFLDEVateTESKPKWKSQKARREELRVHVAN 266

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283  1081 IFELLADagvisDSTNGALERDTLaLGALFLEYV-DLTRMLLEA--ENDKEVEILKDIRAhfSAMVANLIQCVPVHHRRF 1157
Cdd:pfam14228  267 IYRMVAE-----NFWPGMLIRKPV-FRLHVLKFIeDTVRYITTSplENFQDLQPLRFALA--SVLRSLAPEFVKSKSERF 338

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283  1158 lfpQQSLRHHLFILFSQWAGPFSIMFTPlDRYSDRNHQITRY----------------------------QYCALKAMSA 1209
Cdd:pfam14228  339 ---DPRTRKRLFDLLASWCDDTGTVWSQ-DGVSDYRREVERYkssqnsrskdsvdkisfdkevneqveaiQWIAMNAMAA 414

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283  1210 VLCcGPVFDNVGLSPDGYLYKWLDNI--------------------------------LACQD------LRVHqLGCEVV 1251
Cdd:pfam14228  415 LLY-GPCFDDNARKMSGRVIAWINGLflepaprapfgyspadprtpsyskfagegvrgLGGKDrhrggpLRVH-LAKVAL 492

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283  1252 MLLLELNPDqinLFNWAIDRCYTGSYQLASGCFKAIATVCGNRNYP-FDIVTLLNLVLFKASDTNREIYEVSMQLMQILE 1330
Cdd:pfam14228  493 KNLLQTNLD---LFPACIDQCYSSDASIADGYFSVLAEVYMRQEIPrCDIQRLLSLILYKVVDPSRRIRDDALQMLETLS 569

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283  1331 AKLFVHSkkvAEQRPGSILYGTHGPLPPLYSVSLALLSCELARMYPELTLPLFSEVSQR-FPTTHPNGRQIMLTYLLPWL 1409
Cdd:pfam14228  570 VREWAED---GEEGTGRYRAAVVGNLPDSYQQFQYKLSAKLAKDHPELSELLCEEIMQRqLDAVDIIAQHQVLTCMAPWI 646

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283  1410 HNIELVdsrlllpgsspsspedevkdregevtashGLKGNGWgspeaTSLVLNNLMYMTAKYGDEVPGaEMENAWNALAN 1489
Cdd:pfam14228  647 ENLNFL-----------------------------KLWESGW-----SERLLKSLYYVTWRHGDQFPD-EIEKLWRTIAS 691

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283  1490 NEKwsnNLRVTLQFLISLCGVSSDT--------ILLPYI---KKVATYLCRNNTIQTMEELLFELQQ------TEPVNPi 1552
Cdd:pfam14228  692 KPR---NISPVLDFLISKGIEDCDSnasaeitgAFATYFsvaKRVSLYLARICPQQTIDHLVYELAQrmleesVEPSRP- 767

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283  1553 vqhcdnppfyrftasskasAAASGTTSSSNTVVAGQDsfPDPEESKILKESDDRFSNVIrAHTRLESRYSNSSGG----- 1627
Cdd:pfam14228  768 -------------------SDGAFDLESSAVLEFSQG--PAPVQVAQLLDPQPHMSPLL-VRSSLEGPLRNASGSlswrt 825

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283  1628 SYDEDKNDPISPYTGWLLSITEAKQ-----PQPLPMPCSGGcwaPLV-------------------DYLPET-------- 1675
Cdd:pfam14228  826 VTGRSMSGPLNTMPEVVAVDTHTGRsgqlfTGSGPLPNMSG---PLMgvrsstgslrshhvsrdsgDYFIDTpnsveeir 902

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283  1676 ITP-----------RGPLH---RCNIAVIFMTEMVVDHSvrEDWALHLPLLLHAVFLGLDHYRPEVFEHSKklllhllia 1741
Cdd:pfam14228  903 ITPvvnaselqsalQGHQHwlsRADIALILLAEIAYEND--EDFRSHLPLLFHVTFVSMDSSEDIVLKHCQ--------- 971

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283  1742 lscnsnfHAIASVL--LQTREMgeaktltmqpayqpeylytggfdflredqsspvpdsglnssstsssislggssgnlpq 1819
Cdd:pfam14228  972 -------HLLVNLLysLAGRHL---------------------------------------------------------- 986

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939283  1820 mtqEVEDVEAAT-ETDEKASKLIEFLTTRAFGPLWCHEDITPKNQNSKSAEQLSNFLRHVVS--VFKDSrsgfhLEQHLS 1896
Cdd:pfam14228  987 ---ELYDVEHGDgEYKQQVVSLIKYVQSKRGSRMWENEDMTLTRTELPSAALLSALVLSMVDaiFFQGD-----LREKWG 1058

                         1290      1300      1310      1320
                   ....*....|....*....|....*....|....*....|....*..
gi 568939283  1897 EVALQTALASSSRHYAGRSFQIFRALKQPLSAHALSDLLSRLVEVIG 1943
Cdd:pfam14228 1059 EEALKWAMECTSRHLACRSHQIYRALRPSVTSDTCVSLLRCLHRCLG 1105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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