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Conserved domains on  [gi|568933937|ref|XP_006503879|]
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slit homolog 2 protein isoform X4 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LamG smart00282
Laminin G domain;
1183-1316 3.68e-31

Laminin G domain;


:

Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 119.37  E-value: 3.68e-31
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937   1183 NITLQIATDEDSGILLY---KGDKDHIAVELYRGRVRASYDTGSHPASAIYSVETINDGNFHIVELLTLDSSLSLSVDGG 1259
Cdd:smart00282    1 SISFSFRTTSPNGLLLYagsKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDGG 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 568933937   1260 SPKVITNLSKQSTLNFDSPLYVGGMPgknnvASLRQAPGQNGTSFHGCIRNLYINSE 1316
Cdd:smart00282   81 NRVSGESPGGLTILNLDGPLYLGGLP-----EDLKLPPLPVTPGFRGCIRNLKVNGK 132
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
56-211 1.96e-23

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 105.02  E-value: 1.96e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937   56 NTERLDLNGNNITRITKiDFAGLRHLRVLQLMENRISTIERgAFQDLKELERLRLNRNNLQLFPELLfLGTAKLYRLDLS 135
Cdd:COG4886   114 NLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEEL-GNLTNLKELDLS 190

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568933937  136 ENQIQAIPrKAFRGAVDIKNLQLDYNQISCIEDgAFRALRDLEVLTLNNNNITRLSvaSFNHMPKLRTFRLHSNNL 211
Cdd:COG4886   191 NNQITDLP-EPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQL 262
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
736-861 3.63e-22

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 101.16  E-value: 3.63e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  736 TVVRCSNKGLKVLPKGIP--KDVTELYLDGNQFTLVPKELSNYKHLTLIDLSNNRISTLSNqSFSNMTQLLTLILSYNRL 813
Cdd:COG4886   116 ESLDLSGNQLTDLPEELAnlTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQI 194

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 568933937  814 RCIPPrTFDGLKSLRLLSLHGNDISVVPEgAFNDLSALSHLAIGANPL 861
Cdd:COG4886   195 TDLPE-PLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQL 240
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
515-666 5.56e-19

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 91.53  E-value: 5.56e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  515 TTVDCSNQRLNKIPDHIPQYTA--ELRLNNNEFTVLEATgiFKKLPQLRKINFSNNKITDIEEgAFEGASGVNEILLTSN 592
Cdd:COG4886   116 ESLDLSGNQLTDLPEELANLTNlkELDLSNNQLTDLPEP--LGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNN 192

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568933937  593 RLENVqHKMFKGLESLKTLMLRSNRISCVGnDSFIGLGSVRLLSLYDNQITTVApgAFDSLHSLSTLNLLANPF 666
Cdd:COG4886   193 QITDL-PEPLGNLTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQL 262
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
283-452 1.62e-17

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.91  E-value: 1.62e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  283 IVDCRGKGLTEIPTNLPE--TITEIRLEQNSIRVIPPgAFSPYKKLRRLDLSNNQISELaPDAFQGLRSLNSLVLYGNKI 360
Cdd:COG4886   140 ELDLSNNQLTDLPEPLGNltNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQL 217

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  361 TELPKSLfeglfslqllllnankinclrvdafQDLHNLNLLSLYDNKLQTVAKgtFSALRAIQTMHLAQN-----PFICD 435
Cdd:COG4886   218 TDLPEPL-------------------------ANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNqltdlPPLAN 270

                         170
                  ....*....|....*...
gi 568933937  436 CH-LKWLadYLHTNPIET 452
Cdd:COG4886   271 LTnLKTL--DLSNNQLTD 286
PCC super family cl28216
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 637-713 8.78e-11

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 67.41  E-value: 8.78e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937   637 LYDNQITTVAPGAFDSLHSLSTLNLLANPFNCNCHLAWLGEWLRRKRIVTGNPR---CQKPYFLKEIPIQDVAIQDFTCD 713
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEaalCAGPGALAGQPLLGIPLLDSGCD 81
PCC super family cl28216
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 832-1013 2.06e-09

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 62.79  E-value: 2.06e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937   832 LHGNDISVVPEGAFNDLSALSHLAIGANPLYCDCNMQWLSDWVKSE---YKEPGIARCAGPGEMADKLLLTTPSKKFTCq 908
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKgvkVRQPEAALCAGPGALAGQPLLGIPLLDSGC- 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937   909 gpvDITIQAkcnpCLSNPCKNDGTCNNDPVDFYRCTcPYGFKGQDCDVpihACISNPCKHGGTchlkeGENAgfWCTCAD 988
Cdd:TIGR00864   81 ---DEEYVA----CLKDNSSGGGAARSELVIFSAAH-EGLFQPEACNA---FCFSAGHGLAAL-----GEQG--ECLCGA 142

                          170       180
                   ....*....|....*....|....*
gi 568933937   989 GFEGENCEVNIDDCEDNDCENNSTC 1013
Cdd:TIGR00864  143 AQPSEANFACESLCSGPPPPPAAAC 167
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1076-1112 2.92e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.02  E-value: 2.92e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 568933937 1076 DFDDCQD-NKCKNGAHCTDAVNGYTCVCPEGYSGLFCE 1112
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 998-1034 3.10e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.02  E-value: 3.10e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 568933937  998 NIDDCED-NDCENNSTCVDGINNYTCLCPPEYTGELCE 1034
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
PCC super family cl28216
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 182-319 3.16e-06

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 52.39  E-value: 3.16e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937   182 LNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQ------RPRVglyTQCMGPSHLRGH---------- 245
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEkgvkvrQPEA---ALCAGPGALAGQpllgipllds 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937   246 ----------------NVAEVQKREFVCSGHQSFMAPScsvlHCPAAC-TCSNNIVDCRGKGLTEIPTNLPETITEIRLE 308
Cdd:TIGR00864   79 gcdeeyvaclkdnssgGGAARSELVIFSAAHEGLFQPE----ACNAFCfSAGHGLAALGEQGECLCGAAQPSEANFACES 154

                          170
                   ....*....|.
gi 568933937   309 QNSIRVIPPGA 319
Cdd:TIGR00864  155 LCSGPPPPPAA 165
LRRNT smart00013
Leucine rich repeat N-terminal domain;
27-58 5.59e-06

Leucine rich repeat N-terminal domain;


:

Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 44.23  E-value: 5.59e-06
                            10        20        30
                    ....*....|....*....|....*....|..
gi 568933937     27 ACPAQCSCSGSTVDCHGLALRSVPRNIPRNTE 58
Cdd:smart00013    1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1038-1073 1.31e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.39  E-value: 1.31e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568933937 1038 DFCAQDlNPCQHDSKCILTPKGFKCDCTPGYIGEHC 1073
Cdd:cd00054     3 DECASG-NPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
 
Name Accession Description Interval E-value
LamG smart00282
Laminin G domain;
1183-1316 3.68e-31

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 119.37  E-value: 3.68e-31
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937   1183 NITLQIATDEDSGILLY---KGDKDHIAVELYRGRVRASYDTGSHPASAIYSVETINDGNFHIVELLTLDSSLSLSVDGG 1259
Cdd:smart00282    1 SISFSFRTTSPNGLLLYagsKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDGG 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 568933937   1260 SPKVITNLSKQSTLNFDSPLYVGGMPgknnvASLRQAPGQNGTSFHGCIRNLYINSE 1316
Cdd:smart00282   81 NRVSGESPGGLTILNLDGPLYLGGLP-----EDLKLPPLPVTPGFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1161-1314 1.10e-27

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 110.20  E-value: 1.10e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937 1161 SVNFvNKESYLQIP-SAKVRPQTNITLQIATDEDSGILLYKGDK---DHIAVELYRGRVRASYDTGSHPASaIYSVETIN 1236
Cdd:cd00110     1 GVSF-SGSSYVRLPtLPAPRTRLSISFSFRTTSPNGLLLYAGSQnggDFLALELEDGRLVLRYDLGSGSLV-LSSKTPLN 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568933937 1237 DGNFHIVELLTLDSSLSLSVDGGSPKVITNLSKQSTLNFDSPLYVGGMPgknnvASLRQAPGQNGTSFHGCIRNLYIN 1314
Cdd:cd00110    79 DGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLP-----EDLKSPGLPVSPGFVGCIRDLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1190-1316 3.62e-26

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 104.81  E-value: 3.62e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  1190 TDEDSGILLYKGD--KDHIAVELYRGRVRASYDTGSHPASAIYSVETINDGNFHIVELLTLDSSLSLSVDGGSPKVITNL 1267
Cdd:pfam02210    3 TRQPNGLLLYAGGggSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSSLPP 82

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 568933937  1268 SKQSTLNFDSPLYVGGMPGKNNVASLRQAPGqngtsFHGCIRNLYINSE 1316
Cdd:pfam02210   83 GESLLLNLNGPLYLGGLPPLLLLPALPVRAG-----FVGCIRDVRVNGE 126
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
56-211 1.96e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 105.02  E-value: 1.96e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937   56 NTERLDLNGNNITRITKiDFAGLRHLRVLQLMENRISTIERgAFQDLKELERLRLNRNNLQLFPELLfLGTAKLYRLDLS 135
Cdd:COG4886   114 NLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEEL-GNLTNLKELDLS 190

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568933937  136 ENQIQAIPrKAFRGAVDIKNLQLDYNQISCIEDgAFRALRDLEVLTLNNNNITRLSvaSFNHMPKLRTFRLHSNNL 211
Cdd:COG4886   191 NNQITDLP-EPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQL 262
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
736-861 3.63e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 101.16  E-value: 3.63e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  736 TVVRCSNKGLKVLPKGIP--KDVTELYLDGNQFTLVPKELSNYKHLTLIDLSNNRISTLSNqSFSNMTQLLTLILSYNRL 813
Cdd:COG4886   116 ESLDLSGNQLTDLPEELAnlTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQI 194

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 568933937  814 RCIPPrTFDGLKSLRLLSLHGNDISVVPEgAFNDLSALSHLAIGANPL 861
Cdd:COG4886   195 TDLPE-PLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQL 240
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
515-666 5.56e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 91.53  E-value: 5.56e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  515 TTVDCSNQRLNKIPDHIPQYTA--ELRLNNNEFTVLEATgiFKKLPQLRKINFSNNKITDIEEgAFEGASGVNEILLTSN 592
Cdd:COG4886   116 ESLDLSGNQLTDLPEELANLTNlkELDLSNNQLTDLPEP--LGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNN 192

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568933937  593 RLENVqHKMFKGLESLKTLMLRSNRISCVGnDSFIGLGSVRLLSLYDNQITTVApgAFDSLHSLSTLNLLANPF 666
Cdd:COG4886   193 QITDL-PEPLGNLTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQL 262
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
283-452 1.62e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.91  E-value: 1.62e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  283 IVDCRGKGLTEIPTNLPE--TITEIRLEQNSIRVIPPgAFSPYKKLRRLDLSNNQISELaPDAFQGLRSLNSLVLYGNKI 360
Cdd:COG4886   140 ELDLSNNQLTDLPEPLGNltNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQL 217

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  361 TELPKSLfeglfslqllllnankinclrvdafQDLHNLNLLSLYDNKLQTVAKgtFSALRAIQTMHLAQN-----PFICD 435
Cdd:COG4886   218 TDLPEPL-------------------------ANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNqltdlPPLAN 270

                         170
                  ....*....|....*...
gi 568933937  436 CH-LKWLadYLHTNPIET 452
Cdd:COG4886   271 LTnLKTL--DLSNNQLTD 286
LRR_8 pfam13855
Leucine rich repeat;
778-837 1.45e-16

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 75.25  E-value: 1.45e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937   778 HLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDI 837
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
55-115 3.81e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 65.62  E-value: 3.81e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568933937    55 RNTERLDLNGNNITRITKIDFAGLRHLRVLQLMENRISTIERGAFQDLKELERLRLNRNNL 115
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
303-360 7.54e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 64.47  E-value: 7.54e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 568933937   303 TEIRLEQNSIRVIPPGAFSPYKKLRRLDLSNNQISELAPDAFQGLRSLNSLVLYGNKI 360
Cdd:pfam13855    4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
607-666 4.60e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 62.54  E-value: 4.60e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937   607 SLKTLMLRSNRISCVGNDSFIGLGSVRLLSLYDNQITTVAPGAFDSLHSLSTLNLLANPF 666
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 55-209 3.77e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 64.42  E-value: 3.77e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937   55 RNTERLDLNGNNITRITkiDFAGLRHLRVLQLMENRISTIErgAFQDLKELERLRLNRNNLQLFPELLF-----LGTAK- 128
Cdd:cd21340    46 TNLTHLYLQNNQIEKIE--NLENLVNLKKLYLGGNRISVVE--GLENLTNLEELHIENQRLPPGEKLTFdprslAALSNs 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  129 LYRLDLSENQIQaiprkafrgavDIKNLQldynqisciedgafrALRDLEVLTLNNNNITRLSVAS--FNHMPKLRTFRL 206
Cdd:cd21340   122 LRVLNISGNNID-----------SLEPLA---------------PLRNLEQLDASNNQISDLEELLdlLSSWPSLRELDL 175


                  ...
gi 568933937  207 HSN 209
Cdd:cd21340   176 TGN 178
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 637-713 8.78e-11

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 67.41  E-value: 8.78e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937   637 LYDNQITTVAPGAFDSLHSLSTLNLLANPFNCNCHLAWLGEWLRRKRIVTGNPR---CQKPYFLKEIPIQDVAIQDFTCD 713
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEaalCAGPGALAGQPLLGIPLLDSGCD 81
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 754-854 1.32e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 62.88  E-value: 1.32e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  754 KDVTELYLDGNQFTLVPkELSNYKHLTLIDLSNNRISTLSNqsFSNMTQLLTLILSYNRLRCIPPrtFDGLKSLRLLSLH 833
Cdd:cd21340     2 KRITHLYLNDKNITKID-NLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLG 76

                          90       100
                  ....*....|....*....|.
gi 568933937  834 GNDISVVpEGaFNDLSALSHL 854
Cdd:cd21340    77 GNRISVV-EG-LENLTNLEEL 95
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 832-1013 2.06e-09

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 62.79  E-value: 2.06e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937   832 LHGNDISVVPEGAFNDLSALSHLAIGANPLYCDCNMQWLSDWVKSE---YKEPGIARCAGPGEMADKLLLTTPSKKFTCq 908
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKgvkVRQPEAALCAGPGALAGQPLLGIPLLDSGC- 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937   909 gpvDITIQAkcnpCLSNPCKNDGTCNNDPVDFYRCTcPYGFKGQDCDVpihACISNPCKHGGTchlkeGENAgfWCTCAD 988
Cdd:TIGR00864   81 ---DEEYVA----CLKDNSSGGGAARSELVIFSAAH-EGLFQPEACNA---FCFSAGHGLAAL-----GEQG--ECLCGA 142

                          170       180
                   ....*....|....*....|....*
gi 568933937   989 GFEGENCEVNIDDCEDNDCENNSTC 1013
Cdd:TIGR00864  143 AQPSEANFACESLCSGPPPPPAAAC 167
PLN03150 PLN03150
hypothetical protein; Provisional
 769-838 1.95e-08

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 59.06  E-value: 1.95e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  769 VPKELSNYKHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDIS 838
Cdd:PLN03150  434 IPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLS 503
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 55-211 8.81e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 57.17  E-value: 8.81e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937   55 RNTERLDLNGNNITRITKIDFAGLRHLRVLQLMENRISTIERGAFQDLKELERLRLNRNNLqlFPELL-FLGTAKLYRLD 133
Cdd:PLN00113  404 RSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKF--FGGLPdSFGSKRLENLD 481

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568933937  134 LSENQIQ-AIPRKaFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNITRLSVASFNHMPKLRTFRLHSNNL 211
Cdd:PLN00113  482 LSRNQFSgAVPRK-LGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQL 559
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 322-863 2.33e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 55.62  E-value: 2.33e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  322 PYkkLRRLDLSNNQISELAPDA-FQGLRSLNSLVLYGNKITelpKSLFEGLFSLQLLLLNANkiNCLRVDAFQDL---HN 397
Cdd:PLN00113   93 PY--IQTINLSNNQLSGPIPDDiFTTSSSLRYLNLSNNNFT---GSIPRGSIPNLETLDLSN--NMLSGEIPNDIgsfSS 165

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  398 LNLLSLYDNKLQTVAKGTFSALRAIQTMHLAQNPFICDC--------HLKWLadYLHTN------PIETSGarCTSPRRL 463
Cdd:PLN00113  166 LKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIprelgqmkSLKWI--YLGYNnlsgeiPYEIGG--LTSLNHL 241

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  464 A---NKRIGQIKSKKFRCSAKEQYFIpgtedYRSKLSGDCFADLACPEKCrcegTTVDCSNQRLN-KIPDHIPQY-TAE- 537
Cdd:PLN00113  242 DlvyNNLTGPIPSSLGNLKNLQYLFL-----YQNKLSGPIPPSIFSLQKL----ISLDLSDNSLSgEIPELVIQLqNLEi 312

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  538 LRLNNNEFTVLEATGIfKKLPQLRKINFSNNKIT----------------DIEEGAFEG-------ASG-VNEILLTSNR 593
Cdd:PLN00113  313 LHLFSNNFTGKIPVAL-TSLPRLQVLQLWSNKFSgeipknlgkhnnltvlDLSTNNLTGeipeglcSSGnLFKLILFSNS 391

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  594 LENVQHKMFKGLESLKTLMLRSNRISCVGNDSFIGLGSVRLLSLYDNQITtvapGAFDS----LHSLSTLNLLANPFNCN 669
Cdd:PLN00113  392 LEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQ----GRINSrkwdMPSLQMLSLARNKFFGG 467

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  670 chlawLGEWLRRKRIvtgnprcqkpyflkeipiqdvaiqdftcddGNDDnscspLSRcpsectcldtvvrcsNKGLKVLP 749
Cdd:PLN00113  468 -----LPDSFGSKRL------------------------------ENLD-----LSR---------------NQFSGAVP 492

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  750 KGIPK--DVTELYLDGNQFT-LVPKELSNYKHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKS 826
Cdd:PLN00113  493 RKLGSlsELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSGEIPKNLGNVES 572

                         570       580       590
                  ....*....|....*....|....*....|....*....
gi 568933937  827 LRLLSLHGNDI--SVVPEGAFndlSALSHLAIGANPLYC 863
Cdd:PLN00113  573 LVQVNISHNHLhgSLPSTGAF---LAINASAVAGNIDLC 608
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1076-1112 2.92e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.02  E-value: 2.92e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 568933937 1076 DFDDCQD-NKCKNGAHCTDAVNGYTCVCPEGYSGLFCE 1112
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 998-1034 3.10e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.02  E-value: 3.10e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 568933937  998 NIDDCED-NDCENNSTCVDGINNYTCLCPPEYTGELCE 1034
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
287-367 1.08e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 53.55  E-value: 1.08e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  287 RGKGLTEIPTNLPETITEIRLEQNSIRVIP---PGAfspykkLRRLDLSNNQISELAPDAFQGLRSLNslvLYGNKITEL 363
Cdd:PRK15370  228 NSNQLTSIPATLPDTIQEMELSINRITELPerlPSA------LQSLDLFHNKISCLPENLPEELRYLS---VYDNSIRTL 298


                  ....
gi 568933937  364 PKSL 367
Cdd:PRK15370  299 PAHL 302
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 182-319 3.16e-06

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 52.39  E-value: 3.16e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937   182 LNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQ------RPRVglyTQCMGPSHLRGH---------- 245
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEkgvkvrQPEA---ALCAGPGALAGQpllgipllds 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937   246 ----------------NVAEVQKREFVCSGHQSFMAPScsvlHCPAAC-TCSNNIVDCRGKGLTEIPTNLPETITEIRLE 308
Cdd:TIGR00864   79 gcdeeyvaclkdnssgGGAARSELVIFSAAHEGLFQPE----ACNAFCfSAGHGLAALGEQGECLCGAAQPSEANFACES 154

                          170
                   ....*....|.
gi 568933937   309 QNSIRVIPPGA 319
Cdd:TIGR00864  155 LCSGPPPPPAA 165
LRRCT smart00082
Leucine rich repeat C-terminal domain;
859-908 4.81e-06

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 45.11  E-value: 4.81e-06
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 568933937    859 NPLYCDCNMQWLSDWVKSE--YKEPGIARCAGPGEMADKLLLTTPSkKFTCQ 908
Cdd:smart00082    1 NPFICDCELRWLLRWLQANehLQDPVDLRCASPSSLRGPLLELLHS-EFKCP 51
LRRNT smart00013
Leucine rich repeat N-terminal domain;
27-58 5.59e-06

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 44.23  E-value: 5.59e-06
                            10        20        30
                    ....*....|....*....|....*....|..
gi 568933937     27 ACPAQCSCSGSTVDCHGLALRSVPRNIPRNTE 58
Cdd:smart00013    1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1076-1112 8.65e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 8.65e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 568933937   1076 DFDDCQ-DNKCKNGAHCTDAVNGYTCVCPEGYS-GLFCE 1112
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
998-1034 1.05e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 1.05e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 568933937    998 NIDDCE-DNDCENNSTCVDGINNYTCLCPPEYT-GELCE 1034
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1038-1073 1.31e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.39  E-value: 1.31e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568933937 1038 DFCAQDlNPCQHDSKCILTPKGFKCDCTPGYIGEHC 1073
Cdd:cd00054     3 DECASG-NPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
LRRNT smart00013
Leucine rich repeat N-terminal domain;
727-758 1.87e-05

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 42.69  E-value: 1.87e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 568933937    727 CPSECTCLDTVVRCSNKGLKVLPKGIPKDVTE 758
Cdd:smart00013    2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
LRRCT smart00082
Leucine rich repeat C-terminal domain;
209-258 2.74e-05

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 42.80  E-value: 2.74e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 568933937    209 NNLYCDCHLAWLSDWLRQRPRV--GLYTQCMGPSHLRGhNVAEVQKREFVCS 258
Cdd:smart00082    1 NPFICDCELRWLLRWLQANEHLqdPVDLRCASPSSLRG-PLLELLHSEFKCP 51
LRRNT smart00013
Leucine rich repeat N-terminal domain;
272-304 2.93e-05

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 42.30  E-value: 2.93e-05
                            10        20        30
                    ....*....|....*....|....*....|...
gi 568933937    272 HCPAACTCSNNIVDCRGKGLTEIPTNLPETITE 304
Cdd:smart00013    1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1080-1108 3.39e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.98  E-value: 3.39e-05
                           10        20
                   ....*....|....*....|....*....
gi 568933937  1080 CQDNKCKNGAHCTDAVNGYTCVCPEGYSG 1108
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
LRRCT smart00082
Leucine rich repeat C-terminal domain;
664-713 6.37e-05

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 42.03  E-value: 6.37e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 568933937    664 NPFNCNCHLAWLGEWLRRKRIV--TGNPRCQKPYFLKEiPIQDVAIQDFTCD 713
Cdd:smart00082    1 NPFICDCELRWLLRWLQANEHLqdPVDLRCASPSSLRG-PLLELLHSEFKCP 51
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1002-1031 1.36e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 40.44  E-value: 1.36e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 568933937  1002 CEDNDCENNSTCVDGINNYTCLCPPEYTGE 1031
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 27-54 1.71e-04

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 39.92  E-value: 1.71e-04
                           10        20
                   ....*....|....*....|....*...
gi 568933937    27 ACPAQCSCSGSTVDCHGLALRSVPRNIP 54
Cdd:pfam01462    1 ACPVPCHCSATVVNCSDRGLTAVPRDLP 28
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1043-1072 2.96e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 39.29  E-value: 2.96e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 568933937  1043 DLNPCQHDSKCILTPKGFKCDCTPGYIGEH 1072
Cdd:pfam00008    2 APNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 403-466 3.57e-04

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 45.46  E-value: 3.57e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568933937   403 LYDNKLQTVAKGTFSALRAIQTMHLAQNPFICDCHLKWLADYLHTNPIET---SGARCTSPRRLANK 466
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVrqpEAALCAGPGALAGQ 68
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 920-954 7.82e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 7.82e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568933937  920 NPCLS-NPCKNDGTCNNDPVDfYRCTCPYGFKGQDC 954
Cdd:cd00054     3 DECASgNPCQNGGTCVNTVGS-YRCSCPPGYTGRNC 37
LRRNT smart00013
Leucine rich repeat N-terminal domain;
505-535 3.69e-03

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 36.53  E-value: 3.69e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 568933937    505 ACPEKCRCEGTTVDCSNQRLNKIPDHIPQYT 535
Cdd:smart00013    1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDT 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
1038-1074 3.84e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.46  E-value: 3.84e-03
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 568933937   1038 DFCAQDlNPCQHDSKCILTPKGFKCDCTPGYI-GEHCD 1074
Cdd:smart00179    3 DECASG-NPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 922-951 3.93e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.21  E-value: 3.93e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 568933937   922 CLSNPCKNDGTCNNDPVDfYRCTCPYGFKG 951
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGG-YTCICPEGYTG 29
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 302-432 4.21e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.54  E-value: 4.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  302 ITEIRLEQNSIRVIPPgaFSPYKKLRRLDLSNNQISELApdafqGLRSLNSLV-LY--------GNKITELPKSLFEglf 372
Cdd:cd21340    48 LTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVVE-----GLENLTNLEeLHienqrlppGEKLTFDPRSLAA--- 117

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568933937  373 slqllllnankI-NCLRV-----------DAFQDLHNLNLLSLYDNKLQ--TVAKGTFSALRAIQTMHLAQNPF 432
Cdd:cd21340   118 -----------LsNSLRVlnisgnnidslEPLAPLRNLEQLDASNNQISdlEELLDLLSSWPSLRELDLTGNPV 180
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 523-666 4.49e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.15  E-value: 4.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  523 RLNKIP--DHIPQYTaELRLNNNEFTVLEAtgiFKKLPQLRKINFSNNKITDIEegAFEGASGVNEILLTSNRLENVQHK 600
Cdd:cd21340    35 KITKIEnlEFLTNLT-HLYLQNNQIEKIEN---LENLVNLKKLYLGGNRISVVE--GLENLTNLEELHIENQRLPPGEKL 108

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568933937  601 MF-----KGL-ESLKTLMLRSNRISCVgnDSFIGLGSVRLLSLYDNQITTVAP--GAFDSLHSLSTLNLLANPF 666
Cdd:cd21340   109 TFdprslAALsNSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPV 180
 
Name Accession Description Interval E-value
LamG smart00282
Laminin G domain;
1183-1316 3.68e-31

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 119.37  E-value: 3.68e-31
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937   1183 NITLQIATDEDSGILLY---KGDKDHIAVELYRGRVRASYDTGSHPASAIYSVETINDGNFHIVELLTLDSSLSLSVDGG 1259
Cdd:smart00282    1 SISFSFRTTSPNGLLLYagsKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDGG 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 568933937   1260 SPKVITNLSKQSTLNFDSPLYVGGMPgknnvASLRQAPGQNGTSFHGCIRNLYINSE 1316
Cdd:smart00282   81 NRVSGESPGGLTILNLDGPLYLGGLP-----EDLKLPPLPVTPGFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1161-1314 1.10e-27

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 110.20  E-value: 1.10e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937 1161 SVNFvNKESYLQIP-SAKVRPQTNITLQIATDEDSGILLYKGDK---DHIAVELYRGRVRASYDTGSHPASaIYSVETIN 1236
Cdd:cd00110     1 GVSF-SGSSYVRLPtLPAPRTRLSISFSFRTTSPNGLLLYAGSQnggDFLALELEDGRLVLRYDLGSGSLV-LSSKTPLN 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568933937 1237 DGNFHIVELLTLDSSLSLSVDGGSPKVITNLSKQSTLNFDSPLYVGGMPgknnvASLRQAPGQNGTSFHGCIRNLYIN 1314
Cdd:cd00110    79 DGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLP-----EDLKSPGLPVSPGFVGCIRDLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1190-1316 3.62e-26

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 104.81  E-value: 3.62e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  1190 TDEDSGILLYKGD--KDHIAVELYRGRVRASYDTGSHPASAIYSVETINDGNFHIVELLTLDSSLSLSVDGGSPKVITNL 1267
Cdd:pfam02210    3 TRQPNGLLLYAGGggSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSSLPP 82

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 568933937  1268 SKQSTLNFDSPLYVGGMPGKNNVASLRQAPGqngtsFHGCIRNLYINSE 1316
Cdd:pfam02210   83 GESLLLNLNGPLYLGGLPPLLLLPALPVRAG-----FVGCIRDVRVNGE 126
Laminin_G_1 pfam00054
Laminin G domain;
1188-1319 6.99e-24

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 98.54  E-value: 6.99e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  1188 IATDEDSGILLYKGDKDH---IAVELYRGRVRASYDTGSHPASaIYSVETINDGNFHIVELLTLDSSLSLSVDGGSPKVI 1264
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTErdfLALELRDGRLEVSYDLGSGAAV-VRSGDKLNDGKWHSVELERNGRSGTLSVDGEARPTG 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 568933937  1265 TN-LSKQSTLNFDSPLYVGGMPgkNNVASLRQAPgqNGTSFHGCIRNLYINSELQD 1319
Cdd:pfam00054   80 ESpLGATTDLDVDGPLYVGGLP--SLGVKKRRLA--ISPSFDGCIRDVIVNGKPLD 131
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
56-211 1.96e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 105.02  E-value: 1.96e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937   56 NTERLDLNGNNITRITKiDFAGLRHLRVLQLMENRISTIERgAFQDLKELERLRLNRNNLQLFPELLfLGTAKLYRLDLS 135
Cdd:COG4886   114 NLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEEL-GNLTNLKELDLS 190

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568933937  136 ENQIQAIPrKAFRGAVDIKNLQLDYNQISCIEDgAFRALRDLEVLTLNNNNITRLSvaSFNHMPKLRTFRLHSNNL 211
Cdd:COG4886   191 NNQITDLP-EPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQL 262
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
736-861 3.63e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 101.16  E-value: 3.63e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  736 TVVRCSNKGLKVLPKGIP--KDVTELYLDGNQFTLVPKELSNYKHLTLIDLSNNRISTLSNqSFSNMTQLLTLILSYNRL 813
Cdd:COG4886   116 ESLDLSGNQLTDLPEELAnlTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQI 194

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 568933937  814 RCIPPrTFDGLKSLRLLSLHGNDISVVPEgAFNDLSALSHLAIGANPL 861
Cdd:COG4886   195 TDLPE-PLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQL 240
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
520-838 3.66e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 101.16  E-value: 3.66e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  520 SNQRLNKIPDHIPQYTAELRLNNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGafegasgvneilltsnrlenvqh 599
Cdd:COG4886    75 LLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEE----------------------- 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  600 kmFKGLESLKTLMLRSNRISCVGnDSFIGLGSVRLLSLYDNQITTVaPGAFDSLHSLSTLNLlanpfncnchlawlgewl 679
Cdd:COG4886   132 --LANLTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDL------------------ 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  680 rrkrivTGNPrcqkpyfLKEIPiqdvaiqdftcddgnddnscSPLSRCPSectcldtvvrcsnkglkvlpkgipkdVTEL 759
Cdd:COG4886   190 ------SNNQ-------ITDLP--------------------EPLGNLTN--------------------------LEEL 210

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568933937  760 YLDGNQFTLVPKELSNYKHLTLIDLSNNRISTLSnqSFSNMTQLLTLILSYNRLRCIPPrtFDGLKSLRLLSLHGNDIS 838
Cdd:COG4886   211 DLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLT 285
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
52-448 5.27e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 100.78  E-value: 5.27e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937   52 NIPRNTERLDLNGNNITRITKIDFAGLRHLRVLQLMENRistiergAFQDLKELERLRLNRNNLQLFPELLFLGTaKLYR 131
Cdd:COG4886    69 LSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPEELANLT-NLKE 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  132 LDLSENQIQAIPrKAFRGAVDIKNLQLDYNQISCIeDGAFRALRDLEVLTLNNNNITRLSvASFNHMPKLRTFRLHSNNl 211
Cdd:COG4886   141 LDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQ- 216

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  212 ycdchlawlsdwlrqrprvglytqcmgpshlrghnvaevqkrefvcsghqsfmapscsvlhcpaactcsnnivdcrgkgL 291
Cdd:COG4886   217 -------------------------------------------------------------------------------L 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  292 TEIPTNLPE--TITEIRLEQNSIRVIPpgAFSPYKKLRRLDLSNNQISELAPDAfqGLRSLNSLVLYGNKITELP-KSLF 368
Cdd:COG4886   218 TDLPEPLANltNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKlKELE 293

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  369 EGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTVAKGTFSALRAIQTMHLAQNPFICDCHLKWLADYLHTN 448
Cdd:COG4886   294 LLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLG 373
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
736-861 1.38e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 96.16  E-value: 1.38e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  736 TVVRCSNKGLKVLPKGIP--KDVTELYLDGNQFTLVPKELSNYKHLTLIDLSNNRISTLSNqSFSNMTQLLTLILSYNRL 813
Cdd:COG4886   139 KELDLSNNQLTDLPEPLGnlTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQL 217

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 568933937  814 RCIPPrTFDGLKSLRLLSLHGNDISVVPEgaFNDLSALSHLAIGANPL 861
Cdd:COG4886   218 TDLPE-PLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQL 262
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
38-195 1.86e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 92.69  E-value: 1.86e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937   38 TVDCHGLALRSVPRNIPRNT--ERLDLNGNNITRITKiDFAGLRHLRVLQLMENRISTIErGAFQDLKELERLRLNRNNL 115
Cdd:COG4886   140 ELDLSNNQLTDLPEPLGNLTnlKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQL 217

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  116 QLFPELLFlGTAKLYRLDLSENQIQAIPrkAFRGAVDIKNLQLDYNQISCIEDGAfrALRDLEVLTLNNNNITRLSVASF 195
Cdd:COG4886   218 TDLPEPLA-NLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKEL 292
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
754-861 2.65e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 92.30  E-value: 2.65e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  754 KDVTELYLDGNQFTLVPKELSNYKHLTLIDLSNNRISTLSNqSFSNMTQLLTLILSYNRLRCIPPrTFDGLKSLRLLSLH 833
Cdd:COG4886   113 TNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLS 190

                          90       100
                  ....*....|....*....|....*...
gi 568933937  834 GNDISVVPEgAFNDLSALSHLAIGANPL 861
Cdd:COG4886   191 NNQITDLPE-PLGNLTNLEELDLSGNQL 217
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
515-666 5.56e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 91.53  E-value: 5.56e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  515 TTVDCSNQRLNKIPDHIPQYTA--ELRLNNNEFTVLEATgiFKKLPQLRKINFSNNKITDIEEgAFEGASGVNEILLTSN 592
Cdd:COG4886   116 ESLDLSGNQLTDLPEELANLTNlkELDLSNNQLTDLPEP--LGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNN 192

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568933937  593 RLENVqHKMFKGLESLKTLMLRSNRISCVGnDSFIGLGSVRLLSLYDNQITTVApgAFDSLHSLSTLNLLANPF 666
Cdd:COG4886   193 QITDL-PEPLGNLTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQL 262
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
302-667 1.55e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.91  E-value: 1.55e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  302 ITEIRLEQNSirvippgAFSPYKKLRRLDLSNNQISELaPDAFQGLRSLNSLVLYGNKITELPKSLFEglfslqllllna 381
Cdd:COG4886    98 LTELDLSGNE-------ELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEPLGN------------ 157

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  382 nkinclrvdafqdLHNLNLLSLYDNKLQTVAKgtfsalraiqtmHLAQNPficdcHLKWLadYLHTNPIETsgarctspr 461
Cdd:COG4886   158 -------------LTNLKSLDLSNNQLTDLPE------------ELGNLT-----NLKEL--DLSNNQITD--------- 196

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  462 rlankrigqikskkfrcsakeqyfIPGTEDYRSKLsgdcfadlacpekcrcegTTVDCSNQRLNKIPDHIPQYTA--ELR 539
Cdd:COG4886   197 ------------------------LPEPLGNLTNL------------------EELDLSGNQLTDLPEPLANLTNleTLD 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  540 LNNNEFTVLEAtgiFKKLPQLRKINFSNNKITDIEEGAfegasgvneilltsnrlenvqhkmfkGLESLKTLMLRSNRIS 619
Cdd:COG4886   235 LSNNQLTDLPE---LGNLTNLEELDLSNNQLTDLPPLA--------------------------NLTNLKTLDLSNNQLT 285

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 568933937  620 CVGNDSFIGLGSVRLLSLYDNQITTVAPGAFDSLHSLSTLNLLANPFN 667
Cdd:COG4886   286 DLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGL 333
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
283-452 1.62e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.91  E-value: 1.62e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  283 IVDCRGKGLTEIPTNLPE--TITEIRLEQNSIRVIPPgAFSPYKKLRRLDLSNNQISELaPDAFQGLRSLNSLVLYGNKI 360
Cdd:COG4886   140 ELDLSNNQLTDLPEPLGNltNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQL 217

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  361 TELPKSLfeglfslqllllnankinclrvdafQDLHNLNLLSLYDNKLQTVAKgtFSALRAIQTMHLAQN-----PFICD 435
Cdd:COG4886   218 TDLPEPL-------------------------ANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNqltdlPPLAN 270

                         170
                  ....*....|....*...
gi 568933937  436 CH-LKWLadYLHTNPIET 452
Cdd:COG4886   271 LTnLKTL--DLSNNQLTD 286
LRR_8 pfam13855
Leucine rich repeat;
778-837 1.45e-16

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 75.25  E-value: 1.45e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937   778 HLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDI 837
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
38-192 6.61e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.90  E-value: 6.61e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937   38 TVDCHGLALRSVPRNIPR--NTERLDLNGNNITRITKiDFAGLRHLRVLQLMENRISTIERgAFQDLKELERLRLNRNNL 115
Cdd:COG4886   163 SLDLSNNQLTDLPEELGNltNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQL 240

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568933937  116 QLFPELLFLgtAKLYRLDLSENQIQAIPrkAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNITRLSV 192
Cdd:COG4886   241 TDLPELGNL--TNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLEL 313
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
302-680 5.49e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 79.21  E-value: 5.49e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  302 ITEIRLEQNSIRVIPPgAFSPYKKLRRLDLSNNQISELaPDAFQGLRSLNSLVLYGNKITELPKSLfeglfslqllllna 381
Cdd:COG4886   115 LESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPEEL-------------- 178

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  382 nkinclrvdafQDLHNLNLLSLYDNKLQTVAKgTFSALRAIQTMHLAQNPFicdchlkwladylhtNPIETSGARCTspr 461
Cdd:COG4886   179 -----------GNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQL---------------TDLPEPLANLT--- 228

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  462 rlankrigqikskkfrcsakeqyfipgtedyrsKLsgdcfadlacpekcrcegTTVDCSNQRLNKIPD--HIPQYTaELR 539
Cdd:COG4886   229 ---------------------------------NL------------------ETLDLSNNQLTDLPElgNLTNLE-ELD 256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  540 LNNNEFTVLEATGifkKLPQLRKINFSNNKITDIEEGAFEGASGVNeiLLTSNRLENVQHKMFKGLESLKTLMLRSNRIS 619
Cdd:COG4886   257 LSNNQLTDLPPLA---NLTNLKTLDLSNNQLTDLKLKELELLLGLN--SLLLLLLLLNLLELLILLLLLTTLLLLLLLLK 331

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568933937  620 CVGNDSFIGLGSVRLLSLYDNQITTVAPGAFDSLHSLSTLNLLANPFNCNCHLAWLGEWLR 680
Cdd:COG4886   332 GLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLL 392
LRR_8 pfam13855
Leucine rich repeat;
55-115 3.81e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 65.62  E-value: 3.81e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568933937    55 RNTERLDLNGNNITRITKIDFAGLRHLRVLQLMENRISTIERGAFQDLKELERLRLNRNNL 115
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
303-360 7.54e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 64.47  E-value: 7.54e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 568933937   303 TEIRLEQNSIRVIPPGAFSPYKKLRRLDLSNNQISELAPDAFQGLRSLNSLVLYGNKI 360
Cdd:pfam13855    4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
607-666 4.60e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 62.54  E-value: 4.60e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937   607 SLKTLMLRSNRISCVGNDSFIGLGSVRLLSLYDNQITTVAPGAFDSLHSLSTLNLLANPF 666
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
582-642 6.60e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.77  E-value: 6.60e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568933937   582 SGVNEILLTSNRLENVQHKMFKGLESLKTLMLRSNRISCVGNDSFIGLGSVRLLSLYDNQI 642
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
154-211 1.00e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.39  E-value: 1.00e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 568933937   154 KNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNITRLSVASFNHMPKLRTFRLHSNNL 211
Cdd:pfam13855    4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 55-209 3.77e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 64.42  E-value: 3.77e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937   55 RNTERLDLNGNNITRITkiDFAGLRHLRVLQLMENRISTIErgAFQDLKELERLRLNRNNLQLFPELLF-----LGTAK- 128
Cdd:cd21340    46 TNLTHLYLQNNQIEKIE--NLENLVNLKKLYLGGNRISVVE--GLENLTNLEELHIENQRLPPGEKLTFdprslAALSNs 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  129 LYRLDLSENQIQaiprkafrgavDIKNLQldynqisciedgafrALRDLEVLTLNNNNITRLSVAS--FNHMPKLRTFRL 206
Cdd:cd21340   122 LRVLNISGNNID-----------SLEPLA---------------PLRNLEQLDASNNQISDLEELLdlLSSWPSLRELDL 175


                  ...
gi 568933937  207 HSN 209
Cdd:cd21340   176 TGN 178
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 60-211 6.50e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 63.65  E-value: 6.50e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937   60 LDLNGNNITRITkiDFAGLRHLRVLQLMENRISTIErgAFQDLKELERLRLNRNNLQlfpELLFLGT-AKLYRLDLSENQ 138
Cdd:cd21340     7 LYLNDKNITKID--NLSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIE---KIENLENlVNLKKLYLGGNR 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568933937  139 IQAIprKAFRGAVDIKNLQLDYNQIS-----CIEDGAFRALRD-LEVLTLNNNNITrlSVASFNHMPKLRTFRLHSNNL 211
Cdd:cd21340    80 ISVV--EGLENLTNLEELHIENQRLPpgeklTFDPRSLAALSNsLRVLNISGNNID--SLEPLAPLRNLEQLDASNNQI 154
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 637-713 8.78e-11

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 67.41  E-value: 8.78e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937   637 LYDNQITTVAPGAFDSLHSLSTLNLLANPFNCNCHLAWLGEWLRRKRIVTGNPR---CQKPYFLKEIPIQDVAIQDFTCD 713
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEaalCAGPGALAGQPLLGIPLLDSGCD 81
LRR_8 pfam13855
Leucine rich repeat;
128-187 1.16e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 58.30  E-value: 1.16e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937   128 KLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNI 187
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 754-854 1.32e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 62.88  E-value: 1.32e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  754 KDVTELYLDGNQFTLVPkELSNYKHLTLIDLSNNRISTLSNqsFSNMTQLLTLILSYNRLRCIPPrtFDGLKSLRLLSLH 833
Cdd:cd21340     2 KRITHLYLNDKNITKID-NLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLG 76

                          90       100
                  ....*....|....*....|.
gi 568933937  834 GNDISVVpEGaFNDLSALSHL 854
Cdd:cd21340    77 GNRISVV-EG-LENLTNLEEL 95
LRR_8 pfam13855
Leucine rich repeat;
756-813 3.17e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.15  E-value: 3.17e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 568933937   756 VTELYLDGNQFTLVPKE-LSNYKHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRL 813
Cdd:pfam13855    3 LRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
79-139 4.87e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 56.76  E-value: 4.87e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568933937    79 RHLRVLQLMENRISTIERGAFQDLKELERLRLNRNNLQLFPELLFLGTAKLYRLDLSENQI 139
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
801-861 6.85e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 56.38  E-value: 6.85e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568933937   801 TQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVPEGAFNDLSALSHLAIGANPL 861
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
325-408 1.59e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.22  E-value: 1.59e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937   325 KLRRLDLSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKslfeglfslqllllnankinclrvDAFQDLHNLNLLSLY 404
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSP------------------------GAFSGLPSLRYLDLS 57


                   ....
gi 568933937   405 DNKL 408
Cdd:pfam13855   58 GNRL 61
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 832-1013 2.06e-09

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 62.79  E-value: 2.06e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937   832 LHGNDISVVPEGAFNDLSALSHLAIGANPLYCDCNMQWLSDWVKSE---YKEPGIARCAGPGEMADKLLLTTPSKKFTCq 908
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKgvkVRQPEAALCAGPGALAGQPLLGIPLLDSGC- 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937   909 gpvDITIQAkcnpCLSNPCKNDGTCNNDPVDFYRCTcPYGFKGQDCDVpihACISNPCKHGGTchlkeGENAgfWCTCAD 988
Cdd:TIGR00864   81 ---DEEYVA----CLKDNSSGGGAARSELVIFSAAH-EGLFQPEACNA---FCFSAGHGLAAL-----GEQG--ECLCGA 142

                          170       180
                   ....*....|....*....|....*
gi 568933937   989 GFEGENCEVNIDDCEDNDCENNSTC 1013
Cdd:TIGR00864  143 AQPSEANFACESLCSGPPPPPAAAC 167
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
754-861 2.53e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 61.49  E-value: 2.53e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  754 KDVTELYLDGNQFTLVPKELSNYKHLTLIDLSNNR-ISTLSN---------------QSFSNMTQLLTLILSYNRLRCIP 817
Cdd:COG4886    73 LLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEeLSNLTNlesldlsgnqltdlpEELANLTNLKELDLSNNQLTDLP 152

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 568933937  818 PrTFDGLKSLRLLSLHGNDISVVPEgAFNDLSALSHLAIGANPL 861
Cdd:COG4886   153 E-PLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQI 194
LRR_8 pfam13855
Leucine rich repeat;
537-594 4.76e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.68  E-value: 4.76e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 568933937   537 ELRLNNNEFTVLEAtGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRL 594
Cdd:pfam13855    5 SLDLSNNRLTSLDD-GAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 769-838 1.95e-08

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 59.06  E-value: 1.95e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  769 VPKELSNYKHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDIS 838
Cdd:PLN03150  434 IPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLS 503
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
733-861 2.44e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 58.94  E-value: 2.44e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  733 CL---DTVVRCSNKGLKVLPKGIPKDVTELYLDGNQFTLVPKEL-SNYKHLT------------------LIDLSNNRIS 790
Cdd:PRK15370  175 CLknnKTELRLKILGLTTIPACIPEQITTLILDNNELKSLPENLqGNIKTLYansnqltsipatlpdtiqEMELSINRIT 254

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568933937  791 TLSNQSFSnmtQLLTLILSYNRLRCIPPRTFDGlksLRLLSLHGNDISVVPEgafNDLSALSHLAIGANPL 861
Cdd:PRK15370  255 ELPERLPS---ALQSLDLFHNKISCLPENLPEE---LRYLSVYDNSIRTLPA---HLPSGITHLNVQSNSL 316
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 55-211 8.81e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 57.17  E-value: 8.81e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937   55 RNTERLDLNGNNITRITKIDFAGLRHLRVLQLMENRISTIERGAFQDLKELERLRLNRNNLqlFPELL-FLGTAKLYRLD 133
Cdd:PLN00113  404 RSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKF--FGGLPdSFGSKRLENLD 481

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568933937  134 LSENQIQ-AIPRKaFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNITRLSVASFNHMPKLRTFRLHSNNL 211
Cdd:PLN00113  482 LSRNQFSgAVPRK-LGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQL 559
LRR_8 pfam13855
Leucine rich repeat;
380-432 2.30e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.06  E-value: 2.30e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 568933937   380 NANKINCLRVDAFQDLHNLNLLSLYDNKLQTVAKGTFSALRAIQTMHLAQNPF 432
Cdd:pfam13855    9 SNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 322-863 2.33e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 55.62  E-value: 2.33e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  322 PYkkLRRLDLSNNQISELAPDA-FQGLRSLNSLVLYGNKITelpKSLFEGLFSLQLLLLNANkiNCLRVDAFQDL---HN 397
Cdd:PLN00113   93 PY--IQTINLSNNQLSGPIPDDiFTTSSSLRYLNLSNNNFT---GSIPRGSIPNLETLDLSN--NMLSGEIPNDIgsfSS 165

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  398 LNLLSLYDNKLQTVAKGTFSALRAIQTMHLAQNPFICDC--------HLKWLadYLHTN------PIETSGarCTSPRRL 463
Cdd:PLN00113  166 LKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIprelgqmkSLKWI--YLGYNnlsgeiPYEIGG--LTSLNHL 241

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  464 A---NKRIGQIKSKKFRCSAKEQYFIpgtedYRSKLSGDCFADLACPEKCrcegTTVDCSNQRLN-KIPDHIPQY-TAE- 537
Cdd:PLN00113  242 DlvyNNLTGPIPSSLGNLKNLQYLFL-----YQNKLSGPIPPSIFSLQKL----ISLDLSDNSLSgEIPELVIQLqNLEi 312

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  538 LRLNNNEFTVLEATGIfKKLPQLRKINFSNNKIT----------------DIEEGAFEG-------ASG-VNEILLTSNR 593
Cdd:PLN00113  313 LHLFSNNFTGKIPVAL-TSLPRLQVLQLWSNKFSgeipknlgkhnnltvlDLSTNNLTGeipeglcSSGnLFKLILFSNS 391

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  594 LENVQHKMFKGLESLKTLMLRSNRISCVGNDSFIGLGSVRLLSLYDNQITtvapGAFDS----LHSLSTLNLLANPFNCN 669
Cdd:PLN00113  392 LEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQ----GRINSrkwdMPSLQMLSLARNKFFGG 467

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  670 chlawLGEWLRRKRIvtgnprcqkpyflkeipiqdvaiqdftcddGNDDnscspLSRcpsectcldtvvrcsNKGLKVLP 749
Cdd:PLN00113  468 -----LPDSFGSKRL------------------------------ENLD-----LSR---------------NQFSGAVP 492

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  750 KGIPK--DVTELYLDGNQFT-LVPKELSNYKHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKS 826
Cdd:PLN00113  493 RKLGSlsELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSGEIPKNLGNVES 572

                         570       580       590
                  ....*....|....*....|....*....|....*....
gi 568933937  827 LRLLSLHGNDI--SVVPEGAFndlSALSHLAIGANPLYC 863
Cdd:PLN00113  573 LVQVNISHNHLhgSLPSTGAF---LAINASAVAGNIDLC 608
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1076-1112 2.92e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.02  E-value: 2.92e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 568933937 1076 DFDDCQD-NKCKNGAHCTDAVNGYTCVCPEGYSGLFCE 1112
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 998-1034 3.10e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.02  E-value: 3.10e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 568933937  998 NIDDCED-NDCENNSTCVDGINNYTCLCPPEYTGELCE 1034
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
287-367 1.08e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 53.55  E-value: 1.08e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  287 RGKGLTEIPTNLPETITEIRLEQNSIRVIP---PGAfspykkLRRLDLSNNQISELAPDAFQGLRSLNslvLYGNKITEL 363
Cdd:PRK15370  228 NSNQLTSIPATLPDTIQEMELSINRITELPerlPSA------LQSLDLFHNKISCLPENLPEELRYLS---VYDNSIRTL 298


                  ....
gi 568933937  364 PKSL 367
Cdd:PRK15370  299 PAHL 302
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 182-319 3.16e-06

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 52.39  E-value: 3.16e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937   182 LNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQ------RPRVglyTQCMGPSHLRGH---------- 245
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEkgvkvrQPEA---ALCAGPGALAGQpllgipllds 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937   246 ----------------NVAEVQKREFVCSGHQSFMAPScsvlHCPAAC-TCSNNIVDCRGKGLTEIPTNLPETITEIRLE 308
Cdd:TIGR00864   79 gcdeeyvaclkdnssgGGAARSELVIFSAAHEGLFQPE----ACNAFCfSAGHGLAALGEQGECLCGAAQPSEANFACES 154

                          170
                   ....*....|.
gi 568933937   309 QNSIRVIPPGA 319
Cdd:TIGR00864  155 LCSGPPPPPAA 165
LRRCT smart00082
Leucine rich repeat C-terminal domain;
859-908 4.81e-06

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 45.11  E-value: 4.81e-06
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 568933937    859 NPLYCDCNMQWLSDWVKSE--YKEPGIARCAGPGEMADKLLLTTPSkKFTCQ 908
Cdd:smart00082    1 NPFICDCELRWLLRWLQANehLQDPVDLRCASPSSLRGPLLELLHS-EFKCP 51
LRRNT smart00013
Leucine rich repeat N-terminal domain;
27-58 5.59e-06

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 44.23  E-value: 5.59e-06
                            10        20        30
                    ....*....|....*....|....*....|..
gi 568933937     27 ACPAQCSCSGSTVDCHGLALRSVPRNIPRNTE 58
Cdd:smart00013    1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 55-367 6.33e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 51.00  E-value: 6.33e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937   55 RNTERLDLNGNNITRITKIDFAGLRHLRVLQLMENRISTierGAFQDL---KELERLRLNRNNLQ-LFPELLfLGTAKLY 130
Cdd:PLN00113  308 QNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSG---EIPKNLgkhNNLTVLDLSTNNLTgEIPEGL-CSSGNLF 383

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  131 RLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNIT-RLSVASFNhMPKLRTFRLHSN 209
Cdd:PLN00113  384 KLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQgRINSRKWD-MPSLQMLSLARN 462

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  210 NLYcdchlawlsdwlrqrprvGLYTQCMGPSHLRGHNVAEVQKREFVcsgHQSFMapscsvlhcpaactcsnnivdcrgk 289
Cdd:PLN00113  463 KFF------------------GGLPDSFGSKRLENLDLSRNQFSGAV---PRKLG------------------------- 496

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568933937  290 glteiptNLPEtITEIRLEQNSIRVIPPGAFSPYKKLRRLDLSNNQISELAPDAFQGLRSLNSLVLYGNKIT-ELPKSL 367
Cdd:PLN00113  497 -------SLSE-LMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSgEIPKNL 567
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
290-411 6.94e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 50.85  E-value: 6.94e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  290 GLTEIPTNLPETITEIRLEQNSIRVIPPGAfspYKKLRRLDLSNNQISELA---PDAFQGLRslnslvLYGNKITELPKS 366
Cdd:PRK15370  189 GLTTIPACIPEQITTLILDNNELKSLPENL---QGNIKTLYANSNQLTSIPatlPDTIQEME------LSINRITELPER 259

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 568933937  367 LfegLFSLQLLLLNANKINCLRvDAFQDlhNLNLLSLYDNKLQTV 411
Cdd:PRK15370  260 L---PSALQSLDLFHNKISCLP-ENLPE--ELRYLSVYDNSIRTL 298
EGF_CA smart00179
Calcium-binding EGF-like domain;
1076-1112 8.65e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 8.65e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 568933937   1076 DFDDCQ-DNKCKNGAHCTDAVNGYTCVCPEGYS-GLFCE 1112
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
998-1034 1.05e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 1.05e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 568933937    998 NIDDCE-DNDCENNSTCVDGINNYTCLCPPEYT-GELCE 1034
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1038-1073 1.31e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.39  E-value: 1.31e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568933937 1038 DFCAQDlNPCQHDSKCILTPKGFKCDCTPGYIGEHC 1073
Cdd:cd00054     3 DECASG-NPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 280-449 1.79e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 49.02  E-value: 1.79e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  280 SNNIVDCRGKGLTEIPTnLPETITEIRLEQNSIRviPPGA------FSPYKKLRRLDLSNNQIS-----ELApDAFQGLR 348
Cdd:COG5238   189 CNQIGDEGIEELAEALT-QNTTVTTLWLKRNPIG--DEGAeilaeaLKGNKSLTTLDLSNNQIGdegviALA-EALKNNT 264

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  349 SLNSLVLYGNKITE-----LPKSLfEGLFSLQLLLLNANKINCLRVDAFQDL----HNLNLLSLYDNKLQTV-AKGTFSA 418
Cdd:COG5238   265 TVETLYLSGNQIGAegaiaLAKAL-QGNTTLTSLDLSVNRIGDEGAIALAEGlqgnKTLHTLNLAYNGIGAQgAIALAKA 343

                         170       180       190
                  ....*....|....*....|....*....|....
gi 568933937  419 L---RAIQTMHLAQNPfICDCHLKWLADYLHTNP 449
Cdd:COG5238   344 LqenTTLHSLDLSDNQ-IGDEGAIALAKYLEGNT 376
LRRNT smart00013
Leucine rich repeat N-terminal domain;
727-758 1.87e-05

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 42.69  E-value: 1.87e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 568933937    727 CPSECTCLDTVVRCSNKGLKVLPKGIPKDVTE 758
Cdd:smart00013    2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 81-214 1.90e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 48.51  E-value: 1.90e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937   81 LRVLQLMENRIS-TIER---GAFQDLKE-LERLRLNRNNL------QLFPELLFLGtaKLYRLDLSENQI--QAIPR--K 145
Cdd:cd00116   110 LQELKLNNNGLGdRGLRllaKGLKDLPPaLEKLVLGRNRLegasceALAKALRANR--DLKELNLANNGIgdAGIRAlaE 187

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568933937  146 AFRGAVDIKNLQLDYNQISCIED----GAFRALRDLEVLTLNNNNIT-----RLSVASFNHMPKLRTFRLHSNNLYCD 214
Cdd:cd00116   188 GLKANCNLEVLDLNNNGLTDEGAsalaETLASLKSLEVLNLGDNNLTdagaaALASALLSPNISLLTLSLSCNDITDD 265
LRRCT smart00082
Leucine rich repeat C-terminal domain;
209-258 2.74e-05

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 42.80  E-value: 2.74e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 568933937    209 NNLYCDCHLAWLSDWLRQRPRV--GLYTQCMGPSHLRGhNVAEVQKREFVCS 258
Cdd:smart00082    1 NPFICDCELRWLLRWLQANEHLqdPVDLRCASPSSLRG-PLLELLHSEFKCP 51
LRRNT smart00013
Leucine rich repeat N-terminal domain;
272-304 2.93e-05

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 42.30  E-value: 2.93e-05
                            10        20        30
                    ....*....|....*....|....*....|...
gi 568933937    272 HCPAACTCSNNIVDCRGKGLTEIPTNLPETITE 304
Cdd:smart00013    1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1080-1108 3.39e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.98  E-value: 3.39e-05
                           10        20
                   ....*....|....*....|....*....
gi 568933937  1080 CQDNKCKNGAHCTDAVNGYTCVCPEGYSG 1108
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
46-190 3.82e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 48.54  E-value: 3.82e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937   46 LRSVPRNIPRNTERLDLNGNNITRI--TKIDfaglrHLRVLQLMENRISTI-ER--GAFQDL---------------KEL 105
Cdd:PRK15370  211 LKSLPENLQGNIKTLYANSNQLTSIpaTLPD-----TIQEMELSINRITELpERlpSALQSLdlfhnkisclpenlpEEL 285

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  106 ERLRLNRNNLQLFPELLflgTAKLYRLDLSENQIQAIPRKAfrgAVDIKNLQLDYNQISCIEDGAFRALRDLEVltlNNN 185
Cdd:PRK15370  286 RYLSVYDNSIRTLPAHL---PSGITHLNVQSNSLTALPETL---PPGLKTLEAGENALTSLPASLPPELQVLDV---SKN 356


                  ....*
gi 568933937  186 NITRL 190
Cdd:PRK15370  357 QITVL 361
LRRCT smart00082
Leucine rich repeat C-terminal domain;
664-713 6.37e-05

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 42.03  E-value: 6.37e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 568933937    664 NPFNCNCHLAWLGEWLRRKRIV--TGNPRCQKPYFLKEiPIQDVAIQDFTCD 713
Cdd:smart00082    1 NPFICDCELRWLLRWLQANEHLqdPVDLRCASPSSLRG-PLLELLHSEFKCP 51
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 35-190 1.12e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 46.32  E-value: 1.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937   35 SGSTVDCHGL-ALRSVPRNiPRNTERLDLNGNNITRITKIDFA----GLRHLRVLQLMENRIStiERGA------FQDLK 103
Cdd:COG5238   244 SNNQIGDEGViALAEALKN-NTTVETLYLSGNQIGAEGAIALAkalqGNTTLTSLDLSVNRIG--DEGAialaegLQGNK 320

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  104 ELERLRLNRNNLQLfPELLFLGTA-----KLYRLDLSENQIQAIPRKAF----RGAVDIKNLQLDYNQISciEDGAfRAL 174
Cdd:COG5238   321 TLHTLNLAYNGIGA-QGAIALAKAlqentTLHSLDLSDNQIGDEGAIALakylEGNTTLRELNLGKNNIG--KQGA-EAL 396

                         170
                  ....*....|....*.
gi 568933937  175 RDLevltLNNNNITRL 190
Cdd:COG5238   397 IDA----LQTNRLHTL 408
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1002-1031 1.36e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 40.44  E-value: 1.36e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 568933937  1002 CEDNDCENNSTCVDGINNYTCLCPPEYTGE 1031
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
LRR_8 pfam13855
Leucine rich repeat;
177-211 1.49e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.97  E-value: 1.49e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 568933937   177 LEVLTLNNNNITRLSVASFNHMPKLRTFRLHSNNL 211
Cdd:pfam13855    3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL 37
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 27-54 1.71e-04

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 39.92  E-value: 1.71e-04
                           10        20
                   ....*....|....*....|....*...
gi 568933937    27 ACPAQCSCSGSTVDCHGLALRSVPRNIP 54
Cdd:pfam01462    1 ACPVPCHCSATVVNCSDRGLTAVPRDLP 28
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 757-838 2.36e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 44.39  E-value: 2.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  757 TELYLD------GNQFTLVP---KELSNykHLTLIDLSNNRISTLSnqSFSNMTQLLTLILSYNRLRCIPP--RTFDGLK 825
Cdd:cd21340    93 EELHIEnqrlppGEKLTFDPrslAALSN--SLRVLNISGNNIDSLE--PLAPLRNLEQLDASNNQISDLEEllDLLSSWP 168

                          90
                  ....*....|...
gi 568933937  826 SLRLLSLHGNDIS 838
Cdd:cd21340   169 SLRELDLTGNPVC 181
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 727-753 2.66e-04

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 39.53  E-value: 2.66e-04
                           10        20
                   ....*....|....*....|....*..
gi 568933937   727 CPSECTCLDTVVRCSNKGLKVLPKGIP 753
Cdd:pfam01462    2 CPVPCHCSATVVNCSDRGLTAVPRDLP 28
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 273-299 2.74e-04

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 39.53  E-value: 2.74e-04
                           10        20
                   ....*....|....*....|....*..
gi 568933937   273 CPAACTCSNNIVDCRGKGLTEIPTNLP 299
Cdd:pfam01462    2 CPVPCHCSATVVNCSDRGLTAVPRDLP 28
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1043-1072 2.96e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 39.29  E-value: 2.96e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 568933937  1043 DLNPCQHDSKCILTPKGFKCDCTPGYIGEH 1072
Cdd:pfam00008    2 APNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 520-665 2.97e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 45.17  E-value: 2.97e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  520 SNQRLNKIPDHIPQYTA--ELRLNNNEFTVLEATGIFKKL---PQLRKINFSNNKITDieegafEGASGVNEILLTSNRL 594
Cdd:COG5238   193 GDEGIEELAEALTQNTTvtTLWLKRNPIGDEGAEILAEALkgnKSLTTLDLSNNQIGD------EGVIALAEALKNNTTV 266

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  595 E-------NVQH-------KMFKGLESLKTLMLRSNRIscvGNDSFIGLG-------SVRLLSLYDNQITTV-APGAFDS 652
Cdd:COG5238   267 EtlylsgnQIGAegaialaKALQGNTTLTSLDLSVNRI---GDEGAIALAeglqgnkTLHTLNLAYNGIGAQgAIALAKA 343

                         170
                  ....*....|....*.
gi 568933937  653 LH---SLSTLNLLANP 665
Cdd:COG5238   344 LQentTLHSLDLSDNQ 359
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
325-346 3.02e-04

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 39.26  E-value: 3.02e-04
                            10        20
                    ....*....|....*....|..
gi 568933937    325 KLRRLDLSNNQISELAPDAFQG 346
Cdd:smart00369    3 NLRELDLSNNQLSSLPPGAFQG 24
LRR smart00370
Leucine-rich repeats, outliers;
325-346 3.02e-04

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 39.26  E-value: 3.02e-04
                            10        20
                    ....*....|....*....|..
gi 568933937    325 KLRRLDLSNNQISELAPDAFQG 346
Cdd:smart00370    3 NLRELDLSNNQLSSLPPGAFQG 24
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 324-364 3.09e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 39.54  E-value: 3.09e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 568933937   324 KKLRRLDLSNNQISELapDAFQGLRSLNSLVLYGN-KITELP 364
Cdd:pfam12799    1 PNLEVLDLSNNQITDI--PPLAKLPNLETLDLSGNnKITDLS 40
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 49-408 3.44e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.22  E-value: 3.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937   49 VPRNIP--RNTERLDLNGNNITRITKIDFAGLRHLRVLQLMENRISTIERGAFQDLKELERLRLNRNNLQ-LFPELLFlG 125
Cdd:PLN00113  204 IPRELGqmKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIF-S 282

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  126 TAKLYRLDLSENQIQA-IPRKAfrgaVDIKNLQ---LDYNQISCIEDGAFRALRDLEVLTLNNNNITRLSVASFNHMPKL 201
Cdd:PLN00113  283 LQKLISLDLSDNSLSGeIPELV----IQLQNLEilhLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNL 358

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  202 RTFRLHSNNL-------YCDC----HLAWLSDWLR-QRPRVGLYTQCMGPSHLRGHNVAEVQKREFVCSGHQSFMAPScs 269
Cdd:PLN00113  359 TVLDLSTNNLtgeipegLCSSgnlfKLILFSNSLEgEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDIS-- 436

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  270 vlhcpaactcSNNIVDCRGKGLTEIPTnlpetITEIRLEQNSIRVIPPGAFSPyKKLRRLDLSNNQISELAPDAFQGLRS 349
Cdd:PLN00113  437 ----------NNNLQGRINSRKWDMPS-----LQMLSLARNKFFGGLPDSFGS-KRLENLDLSRNQFSGAVPRKLGSLSE 500

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  350 LNSLVLYGNKIT-ELPKSLfEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKL 408
Cdd:PLN00113  501 LMQLKLSENKLSgEIPDEL-SSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQL 559
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 403-466 3.57e-04

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 45.46  E-value: 3.57e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568933937   403 LYDNKLQTVAKGTFSALRAIQTMHLAQNPFICDCHLKWLADYLHTNPIET---SGARCTSPRRLANK 466
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVrqpEAALCAGPGALAGQ 68
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 1085-1106 3.79e-04

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 38.85  E-value: 3.79e-04
                           10        20
                   ....*....|....*....|..
gi 568933937  1085 CKNGAHCTDAVNGYTCVCPEGY 1106
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCPPGY 22
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 177-211 6.03e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 38.77  E-value: 6.03e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 568933937   177 LEVLTLNNNNITRLSvaSFNHMPKLRTFRLHSNNL 211
Cdd:pfam12799    3 LEVLDLSNNQITDIP--PLAKLPNLETLDLSGNNK 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 920-954 7.82e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 7.82e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568933937  920 NPCLS-NPCKNDGTCNNDPVDfYRCTCPYGFKGQDC 954
Cdd:cd00054     3 DECASgNPCQNGGTCVNTVGS-YRCSCPPGYTGRNC 37
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 1081-1108 9.59e-04

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 38.23  E-value: 9.59e-04
                          10        20
                  ....*....|....*....|....*...
gi 568933937 1081 QDNKCKNGAHCTDAVNGYTCVCPEGYSG 1108
Cdd:cd00053     4 ASNPCSNGGTCVNTPGSYRCVCPPGYTG 31
LRRCT smart00082
Leucine rich repeat C-terminal domain;
430-460 1.12e-03

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 38.57  E-value: 1.12e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 568933937    430 NPFICDCHLKWLADYLHTNPI--ETSGARCTSP 460
Cdd:smart00082    1 NPFICDCELRWLLRWLQANEHlqDPVDLRCASP 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 964-996 1.73e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 1.73e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 568933937  964 NPCKHGGTCHLKEGenaGFWCTCADGFEGENCE 996
Cdd:cd00054     9 NPCQNGGTCVNTVG---SYRCSCPPGYTGRNCE 38
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 1003-1034 2.75e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 36.69  E-value: 2.75e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 568933937 1003 EDNDCENNSTCVDGINNYTCLCPPEYTGEL-CE 1034
Cdd:cd00053     4 ASNPCSNGGTCVNTPGSYRCVCPPGYTGDRsCE 36
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 1045-1072 3.41e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 36.69  E-value: 3.41e-03
                          10        20
                  ....*....|....*....|....*...
gi 568933937 1045 NPCQHDSKCILTPKGFKCDCTPGYIGEH 1072
Cdd:cd00053     6 NPCSNGGTCVNTPGSYRCVCPPGYTGDR 33
LRRNT smart00013
Leucine rich repeat N-terminal domain;
505-535 3.69e-03

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 36.53  E-value: 3.69e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 568933937    505 ACPEKCRCEGTTVDCSNQRLNKIPDHIPQYT 535
Cdd:smart00013    1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDT 31
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
279-364 3.83e-03

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 42.07  E-value: 3.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  279 CSNN---IVDCRGKGLTEIPTNLPETITEIRLEQNSIRVIPpgAFSPykKLRRLDLSNNQISELaPDAFQGLRSLNslvL 355
Cdd:PRK15387  198 CLNNgnaVLNVGESGLTTLPDCLPAHITTLVIPDNNLTSLP--ALPP--ELRTLEVSGNQLTSL-PVLPPGLLELS---I 269


                  ....*....
gi 568933937  356 YGNKITELP 364
Cdd:PRK15387  270 FSNPLTHLP 278
EGF_CA smart00179
Calcium-binding EGF-like domain;
1038-1074 3.84e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.46  E-value: 3.84e-03
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 568933937   1038 DFCAQDlNPCQHDSKCILTPKGFKCDCTPGYI-GEHCD 1074
Cdd:smart00179    3 DECASG-NPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 922-951 3.93e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.21  E-value: 3.93e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 568933937   922 CLSNPCKNDGTCNNDPVDfYRCTCPYGFKG 951
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGG-YTCICPEGYTG 29
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 302-432 4.21e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.54  E-value: 4.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  302 ITEIRLEQNSIRVIPPgaFSPYKKLRRLDLSNNQISELApdafqGLRSLNSLV-LY--------GNKITELPKSLFEglf 372
Cdd:cd21340    48 LTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVVE-----GLENLTNLEeLHienqrlppGEKLTFDPRSLAA--- 117

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568933937  373 slqllllnankI-NCLRV-----------DAFQDLHNLNLLSLYDNKLQ--TVAKGTFSALRAIQTMHLAQNPF 432
Cdd:cd21340   118 -----------LsNSLRVlnisgnnidslEPLAPLRNLEQLDASNNQISdlEELLDLLSSWPSLRELDLTGNPV 180
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 1007-1028 4.32e-03

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 36.16  E-value: 4.32e-03
                           10        20
                   ....*....|....*....|..
gi 568933937  1007 CENNSTCVDGINNYTCLCPPEY 1028
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCPPGY 22
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 523-666 4.49e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.15  E-value: 4.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  523 RLNKIP--DHIPQYTaELRLNNNEFTVLEAtgiFKKLPQLRKINFSNNKITDIEegAFEGASGVNEILLTSNRLENVQHK 600
Cdd:cd21340    35 KITKIEnlEFLTNLT-HLYLQNNQIEKIEN---LENLVNLKKLYLGGNRISVVE--GLENLTNLEELHIENQRLPPGEKL 108

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568933937  601 MF-----KGL-ESLKTLMLRSNRISCVgnDSFIGLGSVRLLSLYDNQITTVAP--GAFDSLHSLSTLNLLANPF 666
Cdd:cd21340   109 TFdprslAALsNSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPV 180
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 961-994 6.75e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.44  E-value: 6.75e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 568933937   961 CISNPCKHGGTCHLKEGenaGFWCTCADGFEGEN 994
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPG---GYTCICPEGYTGKR 31
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 390-646 6.94e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 40.42  E-value: 6.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  390 DAFQDLHNLNLLSLYDNKLQTVAKGTFSALRAIQTMHlaqnpficdcHLKwladyLHTNPIETSGAR--CTSPRRLankr 467
Cdd:cd00116    75 QGLTKGCGLQELDLSDNALGPDGCGVLESLLRSSSLQ----------ELK-----LNNNGLGDRGLRllAKGLKDL---- 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  468 igQIKSKKFRCSakeqyfipgtedyRSKLSGDCFADLA--CPEKCRCEgtTVDCSNqrlNKIPDHIPQYTAElrlnnnef 545
Cdd:cd00116   136 --PPALEKLVLG-------------RNRLEGASCEALAkaLRANRDLK--ELNLAN---NGIGDAGIRALAE-------- 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937  546 tvleatgIFKKLPQLRKINFSNNKITDIEEGAFEGAsgvneilltsnrlenvqhkmFKGLESLKTLMLRSNRISCVG--- 622
Cdd:cd00116   188 -------GLKANCNLEVLDLNNNGLTDEGASALAET--------------------LASLKSLEVLNLGDNNLTDAGaaa 240

                         250       260
                  ....*....|....*....|....*.
gi 568933937  623 --NDSFIGLGSVRLLSLYDNQITTVA 646
Cdd:cd00116   241 laSALLSPNISLLTLSLSCNDITDDG 266
LRR_9 pfam14580
Leucine-rich repeat;
540-619 8.29e-03

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 38.98  E-value: 8.29e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933937   540 LNNNEFTVLEAtgiFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRL-ENVQHKMFKGLESLKTLMLRSNRI 618
Cdd:pfam14580   49 FSDNEIRKLDG---FPLLRRLKTLLLNNNRICRIGEGLGEALPNLTELILTNNNLqELGDLDPLASLKKLTFLSLLRNPV 125


                   .
gi 568933937   619 S 619
Cdd:pfam14580  126 T 126
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 537-575 9.23e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 35.68  E-value: 9.23e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 568933937   537 ELRLNNNEFTVLEAtgiFKKLPQLRKINFS-NNKITDIEE 575
Cdd:pfam12799    5 VLDLSNNQITDIPP---LAKLPNLETLDLSgNNKITDLSD 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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