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Conserved domains on  [gi|568928324|ref|XP_006502780|]
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granulocyte colony-stimulating factor receptor isoform X3 [Mus musculus]

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 10047472)

fibronectin type III (FN3) domain-containing protein may be involved in specific interactions with other molecules through its FN3 domain

Gene Ontology:  GO:0005515
PubMed:  8981327

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
397-478 6.62e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


:

Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.61  E-value: 6.62e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568928324   397 PPHAPALHLKHVGTTWAQLEWVPEAPRLGMIPLTHYTIFWADAGDHSFSVTLNISLHDFVLKHLEPASLYHVYLMATSRA 476
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80

                   ..
gi 568928324   477 GS 478
Cdd:smart00060  81 GE 82
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
221-293 4.41e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 39.79  E-value: 4.41e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568928324 221 SVQLFWKPTPlqEDSGQIQGYLLSWSSPD-HQGQDIHLCNTTQLSCIF--LLPSEAQNVTLVAYNKAGTSSPTTVV 293
Cdd:cd00063   16 SVTLSWTPPE--DDGGPITGYVVEYREKGsGDWKEVEVTPGSETSYTLtgLKPGTEYEFRVRAVNGGGESPPSESV 89
 
Name Accession Description Interval E-value
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
397-478 6.62e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.61  E-value: 6.62e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568928324   397 PPHAPALHLKHVGTTWAQLEWVPEAPRLGMIPLTHYTIFWADAGDHSFSVTLNISLHDFVLKHLEPASLYHVYLMATSRA 476
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80

                   ..
gi 568928324   477 GS 478
Cdd:smart00060  81 GE 82
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
398-488 2.68e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.95  E-value: 2.68e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568928324 398 PHAP-ALHLKHVGTTWAQLEWVPeaPRLGMIPLTHYTIFWADAGDHSFSV--TLNISLHDFVLKHLEPASLYHVYLMATS 474
Cdd:cd00063    1 PSPPtNLRVTDVTSTSVTLSWTP--PEDDGGPITGYVVEYREKGSGDWKEveVTPGSETSYTLTGLKPGTEYEFRVRAVN 78
                         90
                 ....*....|....*
gi 568928324 475 RAG-STNSTGLTLRT 488
Cdd:cd00063   79 GGGeSPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
403-477 9.04e-06

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 44.33  E-value: 9.04e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568928324  403 LHLKHVGTTWAQLEWVPeaPRLGMIPLTHYTIFW--ADAGDHSFSVTLNISLHDFVLKHLEPASLYHVYLMATSRAG 477
Cdd:pfam00041   6 LTVTDVTSTSLTVSWTP--PPDGNGPITGYEVEYrpKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
221-293 4.41e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 39.79  E-value: 4.41e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568928324 221 SVQLFWKPTPlqEDSGQIQGYLLSWSSPD-HQGQDIHLCNTTQLSCIF--LLPSEAQNVTLVAYNKAGTSSPTTVV 293
Cdd:cd00063   16 SVTLSWTPPE--DDGGPITGYVVEYREKGsGDWKEVEVTPGSETSYTLtgLKPGTEYEFRVRAVNGGGESPPSESV 89
 
Name Accession Description Interval E-value
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
397-478 6.62e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.61  E-value: 6.62e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568928324   397 PPHAPALHLKHVGTTWAQLEWVPEAPRLGMIPLTHYTIFWADAGDHSFSVTLNISLHDFVLKHLEPASLYHVYLMATSRA 476
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80

                   ..
gi 568928324   477 GS 478
Cdd:smart00060  81 GE 82
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
398-488 2.68e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.95  E-value: 2.68e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568928324 398 PHAP-ALHLKHVGTTWAQLEWVPeaPRLGMIPLTHYTIFWADAGDHSFSV--TLNISLHDFVLKHLEPASLYHVYLMATS 474
Cdd:cd00063    1 PSPPtNLRVTDVTSTSVTLSWTP--PEDDGGPITGYVVEYREKGSGDWKEveVTPGSETSYTLTGLKPGTEYEFRVRAVN 78
                         90
                 ....*....|....*
gi 568928324 475 RAG-STNSTGLTLRT 488
Cdd:cd00063   79 GGGeSPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
403-477 9.04e-06

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 44.33  E-value: 9.04e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568928324  403 LHLKHVGTTWAQLEWVPeaPRLGMIPLTHYTIFW--ADAGDHSFSVTLNISLHDFVLKHLEPASLYHVYLMATSRAG 477
Cdd:pfam00041   6 LTVTDVTSTSLTVSWTP--PPDGNGPITGYEVEYrpKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
221-293 4.41e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 39.79  E-value: 4.41e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568928324 221 SVQLFWKPTPlqEDSGQIQGYLLSWSSPD-HQGQDIHLCNTTQLSCIF--LLPSEAQNVTLVAYNKAGTSSPTTVV 293
Cdd:cd00063   16 SVTLSWTPPE--DDGGPITGYVVEYREKGsGDWKEVEVTPGSETSYTLtgLKPGTEYEFRVRAVNGGGESPPSESV 89
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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