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Conserved domains on  [gi|568922250|ref|XP_006501283|]
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alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 isoform X2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GT29 super family cl45931
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 72-297 2.36e-171

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


The actual alignment was detected with superfamily member cd23975:

Pssm-ID: 480271  Cd Length: 226  Bit Score: 473.27  E-value: 2.36e-171
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922250  72 CNHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMTMVRVVSHTSVPLLLKNPDYFFKEASRTIYVIWG 151
Cdd:cd23975    1 CDLCAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTIRVVSHTSVPLLLKNPDYFFKETNETIYVIWG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922250 152 PFRNMRKDGNGIVYNMLKKTVDAYPDAQIYVTTEQQMTHCDRVFKDETGKDRVQSGSYLSTGWFTFILAMDACYSIHVYG 231
Cdd:cd23975   81 PFRNMRKDGKGIVYNMLKKAVESYPQAKIYVTTEKRMSYCDTVFKKETGKDRVQSGSYLSTGWFTLILAMDACYGIHVYG 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568922250 232 MINETYCKTEGYRKVPYHYYEQGKDECNEYLLHEHAPYGGHRFITEKKVFAKWAKKHRIVFTHPNW 297
Cdd:cd23975  161 MINDTYCKTEGYRKVPYHYYEPGRDECDEYFLHENAPYGGHRFITEKKVFAKWAKKHPITFTHPNW 226
 
Name Accession Description Interval E-value
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 72-297 2.36e-171

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 473.27  E-value: 2.36e-171
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922250  72 CNHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMTMVRVVSHTSVPLLLKNPDYFFKEASRTIYVIWG 151
Cdd:cd23975    1 CDLCAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTIRVVSHTSVPLLLKNPDYFFKETNETIYVIWG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922250 152 PFRNMRKDGNGIVYNMLKKTVDAYPDAQIYVTTEQQMTHCDRVFKDETGKDRVQSGSYLSTGWFTFILAMDACYSIHVYG 231
Cdd:cd23975   81 PFRNMRKDGKGIVYNMLKKAVESYPQAKIYVTTEKRMSYCDTVFKKETGKDRVQSGSYLSTGWFTLILAMDACYGIHVYG 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568922250 232 MINETYCKTEGYRKVPYHYYEQGKDECNEYLLHEHAPYGGHRFITEKKVFAKWAKKHRIVFTHPNW 297
Cdd:cd23975  161 MINDTYCKTEGYRKVPYHYYEPGRDECDEYFLHENAPYGGHRFITEKKVFAKWAKKHPITFTHPNW 226
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 72-287 7.20e-21

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 89.20  E-value: 7.20e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922250   72 CNHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMTMVRVVSHTSVP---------------------L 130
Cdd:pfam00777  43 CRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGSKTTLRTMNPESAIdskygnlgfshprdpfvefvlV 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922250  131 LLKNPDYFF---------KEASRTIYVIWGPFRNMRKDGNGIVYNmlkktvdayPDAQIYVTteqqmthcdRVFKDETGK 201
Cdd:pfam00777 123 PFKGRDLLWlpafltkgnVSRSLRVLYTLKEVKIPVDPDKVLFLH---------PDFLRYVA---------NFWLRSHGL 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922250  202 DrvqsGSYLSTGWFTFILAMDACYSIHVYGMINEtycktEGYRKVPYHYYEQGKDecneyllHEHAPYGGHRFITEKKVF 281
Cdd:pfam00777 185 K----GRRPSTGLLMLSLALHLCDEVSLYGFGPF-----LDSRGNSHHYYDNVLM-------KKGGFYGVHDMPFEFKLL 248


                  ....*.
gi 568922250  282 AKWAKK 287
Cdd:pfam00777 249 QKLHKE 254
 
Name Accession Description Interval E-value
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 72-297 2.36e-171

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 473.27  E-value: 2.36e-171
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922250  72 CNHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMTMVRVVSHTSVPLLLKNPDYFFKEASRTIYVIWG 151
Cdd:cd23975    1 CDLCAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTIRVVSHTSVPLLLKNPDYFFKETNETIYVIWG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922250 152 PFRNMRKDGNGIVYNMLKKTVDAYPDAQIYVTTEQQMTHCDRVFKDETGKDRVQSGSYLSTGWFTFILAMDACYSIHVYG 231
Cdd:cd23975   81 PFRNMRKDGKGIVYNMLKKAVESYPQAKIYVTTEKRMSYCDTVFKKETGKDRVQSGSYLSTGWFTLILAMDACYGIHVYG 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568922250 232 MINETYCKTEGYRKVPYHYYEQGKDECNEYLLHEHAPYGGHRFITEKKVFAKWAKKHRIVFTHPNW 297
Cdd:cd23975  161 MINDTYCKTEGYRKVPYHYYEPGRDECDEYFLHENAPYGGHRFITEKKVFAKWAKKHPITFTHPNW 226
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 72-295 1.04e-125

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 357.71  E-value: 1.04e-125
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922250  72 CNHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMTMVRVVSHTSVPLLLKNPD-YFFKEASRTIYVIW 150
Cdd:cd23965    1 CDTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRGYEKDVGRRTTIRVVSHSSLPRLLRNAIlLLAGTRAPTVVVFW 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922250 151 GPFRNMRKDGNGIvYNMLKKTVDAYPDAQIYVTTEQQMTHCDRVFKDETGKDRVQSGSYLSTGWFTFILAMDACYSIHVY 230
Cdd:cd23965   81 GPETKMNKDGAGK-YNLLRSLSKKYPDVEFYSLTPEKMDYADELFEKETGKSRIKSGTWLSTGWFTMLLALDVCDEIKVY 159

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568922250 231 GMINETYCKTEGYRKVPYHYYEQ-GKDECNEYLLHEHAPYGGHRFITEKKVFAKWAKKHRIVFTHP 295
Cdd:cd23965  160 GMVPENYCREHPNSKVPYHYYEPgGLKECTYYNYHENALKGGHRFITEKAVFARWAKKYNITFHHP 225
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 72-298 5.43e-119

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 341.07  E-value: 5.43e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922250  72 CNHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMTMVRVVSHTSVPLLLKNPDYFFKEASRTIYVIWG 151
Cdd:cd23977    1 CRRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSLRVVSHTSVPLLLRNQGYFFQQSRDTKYVIWG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922250 152 PFRNMRKDGNGIVYNMLKKTVDAYPDAQIYVTTEQQMTHCDRVFKDETGKDRVQSGSYLSTGWFTFILAMDACYSIHVYG 231
Cdd:cd23977   81 PERNMDRDGGGKTYRALLTLAKMYPHLQVYTLTEEKMAYCDGVFQNETGKNRMKSGSFLSTGWFTMILALELCEEILVYG 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568922250 232 MINETYCKTEGYRKVPYHYYEQGK-DECNEYLLHEHAPYGGHRFITEKKVFAKWAKKHRIVFTHPNWT 298
Cdd:cd23977  161 MVSDSYCRNKNHSSVPYHYYEKGRlDECRMYLVHERAPRGGHRFITEKAIFSRWAKRKKIRFAHPSWT 228
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 72-297 6.79e-90

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 267.11  E-value: 6.79e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922250  72 CNHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMTMVRVVSHTSVPLLLKNPDYFFKEASRTIYVIWG 151
Cdd:cd23978    1 CHQCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTLRVVAHSSVYRVLRRPQEFLNRTPETTLIFWG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922250 152 PFRNMRKDGNGIVYNMLKKTVDAYPDAQIYVTTEQQMTHCDRVFKDETGKDRVQSGSYLSTGWFTFILAMDACYSIHVYG 231
Cdd:cd23978   81 PPNKMQKDGKSNLFRIIQRASMTFPNMSAFVVSPRRMRQFDDLFRGETGRDRKKSHSWLSTGWFTMVIAVELCDNVHVYG 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568922250 232 MINETYC-KTEGYRKVPYHYYE-QGKDECNEYLLHEHAPYGG-HRFITEKKVFAKWAKKHRIVFTHPNW 297
Cdd:cd23978  161 MVPPNYCsKRPTPKKMPYHYYEpKGPDECVTYIQNEHGRRGNhHRFITEKRVFARWAEHYNITFSHPSW 229
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 58-297 2.97e-86

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 258.64  E-value: 2.97e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922250  58 GYINVRTQEPLQLNCNHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMTMVRVVSHTSVPLLLKNPDY 137
Cdd:cd23976    1 GYISIIDHKPLKMHCKSCALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSLRVIAHSSIQRILRNRNE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922250 138 FFKEASRTIYVIWGPFRNMRKDGNGIVYNMLKKTVDAYPDAQIYVTTEQQMTHCDRVFKDETGKDRVQSGSYLSTGWFTF 217
Cdd:cd23976   81 LLNVSQGTVFIFWGPSNYMRRDGKGLVYNNLQLMNQILPKLKVYTITRHKMLQFDELFKRETGKDRKISNTWLSTGWFTM 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922250 218 ILAMDACYSIHVYGMINETYCKTEGYRKVPYHYYE-QGKDECNEYLLHEHAPYGG-HRFITEKKVFAKWAKKHRIVFTHP 295
Cdd:cd23976  161 IIALELCDRINVYGMVPPDFCRDPNHPSVPYHYYEpSGPDECTMYISHERGRKGShHRFITEKRVFANWARTFNIHFYQP 240


                 ..
gi 568922250 296 NW 297
Cdd:cd23976  241 DW 242
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 75-284 1.27e-46

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 155.21  E-value: 1.27e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922250  75 CAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMTMVRVVSHTSVPLLLKNPDYFF---KEASRTIYVIWG 151
Cdd:cd19952    1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKGFEKDVGSKTTFRVLNSKWAGFYLRGPRCGChplPLEEEVVLILSR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922250 152 PFRNMRKDgngivynmLKKTVDAYPDAQIYVTTEQQ--MTHCDRVFKDETGKDrVQSGSYLSTGWFTFILAMDACYSIHV 229
Cdd:cd19952   81 AAAADFKR--------LKRRKKRHDNAVLLLTDPAPdlLSYVRKRLEKLGLKS-FFGGNAPSSGLLAVLLALQLCDSVDL 151

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 568922250 230 YGMINEtyckTEGYRKVPYHYYEQGKDECneyllhehaPYGGHRFITEKKVFAKW 284
Cdd:cd19952  152 YGFGVD----SGHAPKVPYHYYDLVEAEE---------GTAVHSFDLEAELLRAL 193
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 72-287 7.20e-21

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 89.20  E-value: 7.20e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922250   72 CNHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMTMVRVVSHTSVP---------------------L 130
Cdd:pfam00777  43 CRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGSKTTLRTMNPESAIdskygnlgfshprdpfvefvlV 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922250  131 LLKNPDYFF---------KEASRTIYVIWGPFRNMRKDGNGIVYNmlkktvdayPDAQIYVTteqqmthcdRVFKDETGK 201
Cdd:pfam00777 123 PFKGRDLLWlpafltkgnVSRSLRVLYTLKEVKIPVDPDKVLFLH---------PDFLRYVA---------NFWLRSHGL 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922250  202 DrvqsGSYLSTGWFTFILAMDACYSIHVYGMINEtycktEGYRKVPYHYYEQGKDecneyllHEHAPYGGHRFITEKKVF 281
Cdd:pfam00777 185 K----GRRPSTGLLMLSLALHLCDEVSLYGFGPF-----LDSRGNSHHYYDNVLM-------KKGGFYGVHDMPFEFKLL 248


                  ....*.
gi 568922250  282 AKWAKK 287
Cdd:pfam00777 249 QKLHKE 254
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 67-288 4.77e-17

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 79.80  E-value: 4.77e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922250  67 PLQLNCNHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMTMVRVVS-HTSVPLLLKNPDYFFKEASRT 145
Cdd:cd23973   78 PGGDGCIRCAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVIKGYEEDVGTRTSFYVHTaHSITSSLMILQKRGFKNIPQD 157

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922250 146 IYVIWGPFRNMRKDGNGIVYNMLKKTVDAYP----DAQIYVTTEQQMT-----HCD--RVFKDETGKDRVQSGSYL---- 210
Cdd:cd23973  158 KDIKYILFPEGPRDYQWLEALLKNKTIPSGAyygrRPRSYFSGDFTEDkylvlHPDflRYVKNRFLRSKTLKGKYWaiyr 237

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568922250 211 -STGWFTFILAMDACYSIHVYGMInetyckTEGYRKVPYHYYEQGKDECneyllhehAPYGGHRFITEKKVfakWAKKH 288
Cdd:cd23973  238 pTTGAFLLLTALHLCDTVSAYGFI------TEDYRKYPDHYYDKKKTKL--------VFYINHDFRLEKKL---WKRLH 299
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 44-152 1.43e-15

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 75.00  E-value: 1.43e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922250  44 PLPYTFRQPLRTHYgyinvrtQEPLQLNCNH---CAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMTMV 120
Cdd:cd23968   21 TSPFKDLLSLRYPF-------PESSLENTKRyntCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPTKGFEKDVGSKTTL 93

                         90       100       110
                 ....*....|....*....|....*....|....
gi 568922250 121 RVVSHTsvpLLLKNPDYFFKEASRT--IYVIWGP 152
Cdd:cd23968   94 RLINSQ---ILSKPEFNFLTDPLYRnvTLLVWDP 124
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 75-255 4.95e-15

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 73.45  E-value: 4.95e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922250  75 CAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGY----MTMVRVVSHTSVPLLLKNPDY-FFKEASRTI--Y 147
Cdd:cd23963   66 CAVVGNSGILLGSGCGKEIDSHDFVIRCNLPPIKGFEKDVGRktnlTTLNPSILKRRYNSLKKNRDRdKFLNRLKEYngS 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922250 148 VIWGPfrnmrKDGNGIVYNMLKKTVDAYPDaqiyVTTEQQMTHCDRVFKDETGK--DRVQSGSYLSTGWFTFILAMDACY 225
Cdd:cd23963  146 ILWYP-----KFSFKSSTNLLLKAARALKK----NGLNLTVVYSNPEHFLAVQKfwKRRGLEKRPSTGLYLVSLALTFCD 216

                        170       180       190
                 ....*....|....*....|....*....|....
gi 568922250 226 SIHVYG----MINETycktegYRKVPYHYYEQGK 255
Cdd:cd23963  217 EIHLYGfwpfPTDPN------GRPVPYHYYDDLS 244
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 75-256 1.22e-14

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 72.18  E-value: 1.22e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922250  75 CAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMTMVRVVSHTsvplLLKNPDYFFKEAS---RTIYVIWG 151
Cdd:cd23986   52 CAVVTSAGAILNSSLGKEIDSHDAVLRFNSAPTRGYEKDVGNKTTIRIINSQ----ILTNPNHHFIDSSlykDVILVAWD 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922250 152 P---FRNMRKDGNGIVYNMLKKTVD---AYPDAQIYVTTEQQMTHCDRVFKDETgKDRVQSGSyLSTGWFTFILAMDACY 225
Cdd:cd23986  128 PapySANLHKWYKKPDYNLFTPYVQyrkRNPNQPFYILHPKFIWQLWDIIQENT-QEKIQPNP-PSSGFIGILIMMSMCR 205

                        170       180       190
                 ....*....|....*....|....*....|..
gi 568922250 226 SIHVYGMInetycktEGYRKVPY-HYYEQGKD 256
Cdd:cd23986  206 EVHVYEYI-------PSVRQTDLcHYHERYYD 230
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 72-292 4.51e-13

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 68.08  E-value: 4.51e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922250  72 CNHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMTMVRVV---------SHTSVPLL-LKNPDY-FFK 140
Cdd:cd23966   77 CRRCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKGFEKDVGSKTTHHFMypesavdldPGVHLVLVpFKVLDLqWLI 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922250 141 EASRTIYVIWGPFRnmrkdgngivynmLKKTVDAYPD-AQIYVTTEQQMTHcDRVFKDEtgkdrvqsGSYLSTGWFTFIL 219
Cdd:cd23966  157 SALTTGEITRTYTP-------------VKRFIKADKDkVLVINPAFIKYVH-DNWTEHH--------GRYPSTGFLALIF 214

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568922250 220 AMDACYSIHVYGMINETYckteGYRkvpYHYYEqgkdecNEYLLHEHAPYGGHRFITEKKVFAKWAKKHRIVF 292
Cdd:cd23966  215 ALHICDEVSVFGFGADSK----GNW---HHYWE------KNRSAGAFRKTGVHDADFESDIIKKLAKEGKIRV 274
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 72-289 5.91e-12

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 64.97  E-value: 5.91e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922250  72 CNHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVG-----YMTMVR--VVSHTSVPLLLKNPDYFFkEASR 144
Cdd:cd23964   82 CIRCAVVGNGGILNGSGKGKEIDAHDYVFRVNHALTKGFEKDVGtktsfYTFFPEslHNSLLKHVPQDKDTKYLF-IPFK 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922250 145 T---IYVI----WGPFRNMrKDGNGIVYNMLKKTVDA------YPDAQIYVtteqqmtHCDRVfkdetgkdRVQSGSYLS 211
Cdd:cd23964  161 IrdyDYLDavlsGKPVPDG-CDKGKRPPPLFGPKLNAtnvrllHPDFIRYL-------FNRWL--------NSSTSYRPT 224

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568922250 212 TGWFTFILAMDACYSIHVYGMINEtycktegyRKVPYHYYEQGKdecneyllHEHAP-YGGHRFITEKKVfakWAKKHR 289
Cdd:cd23964  225 TGALMLLTALHTCDQVSVYGFGYD--------PRFSLHYYDKTF--------VKFTVfYANHDFTNERKL---WRKLHE 284
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 72-123 1.64e-11

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 62.31  E-value: 1.64e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 568922250  72 CNHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMTMVRVV 123
Cdd:cd23967    2 CRRCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKGYEKDVGSKTTFRMF 53
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 65-231 2.92e-11

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 62.59  E-value: 2.92e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922250  65 QEPLQLNCNHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMTMVRVVSHTSvplllknpdyfFKEASR 144
Cdd:cd23980   74 LEKRLVSCRRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEGFEADVGSKTTHHFVYPES-----------FRELAQ 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922250 145 TIYVIWGPFR--NMRKDGNGIVYNMLKKTVDAYPdAQIYVTTEQQMTHCDRVFKDETGKDRVQSGSYLSTGWFTFILAMD 222
Cdd:cd23980  143 NVSMILVPFKtlDLEWVISATTTGTISHTYVPVP-RKIKVKKEKILIYHPAFIKYVFDRWLQGHGRYPSTGILSVIFSLH 221


                 ....*....
gi 568922250 223 ACYSIHVYG 231
Cdd:cd23980  222 VCDEVDLYG 230
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 64-252 3.32e-11

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 62.41  E-value: 3.32e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922250  64 TQEPLQLNC-NHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMTMVRvvshTSVPLLLknpDYFFKEA 142
Cdd:cd23970   59 EVSPFQNKHyNTCAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPTEGFEKDVGRKTNLT----TFNPSIL---EKYYNNL 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922250 143 SrTIYVIWGPFRNMRKDGNGIVY---------NMLKKTVDAYPDAQIYVTTEQQ------MTHCDRVFKDETGKDRvqsg 207
Cdd:cd23970  132 L-TIQDRNNFFLSLKKLDGAILWipafffhtsATVTRTLVDFFVEHRGQLKVQLawpgniMQHVNRYWKTKHLSPK---- 206

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 568922250 208 sYLSTGWFTFILAMDACYSIHVYGMINETYCKTEgyRKVPYHYYE 252
Cdd:cd23970  207 -RLSTGILMYTLASAICEEIHLYGFWPFGFDPTG--TPLPYHYYD 248
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 75-152 3.39e-11

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 62.42  E-value: 3.39e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922250  75 CAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMTMVRVVSHTsvplLLKNPDYFFKEAS---RTIYVIWG 151
Cdd:cd23985   48 CAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPTAGFQQDVGTKTTIRLINSQ----LVTTEKHKFLKDSlynEGILIVWD 123


                 .
gi 568922250 152 P 152
Cdd:cd23985  124 P 124
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 72-254 6.77e-11

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 60.45  E-value: 6.77e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922250  72 CNHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMTMVRVV---SHTSVPLLLKNPDYF-----FKEAS 143
Cdd:cd23982    2 CRRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFypeSAQFDPGIENDPDTLlvlvpFKPLD 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922250 144 -RTIYVIWGPFRNMRKDGngivYNMLKKTVDAYPdAQIYVTTEQQMTHCDRVFKDETGKDrvQSGSYLSTGWFTFILAMD 222
Cdd:cd23982   82 fYWLYEILSNEKRVRKGF----WKQPPRIWDANP-KQIRILNPYYTYVAATKLLQVPGQR--KKKQKPTTGLLAITLALH 154

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 568922250 223 ACYSIHVYGMinetyckteGY-----RKVPYHYYEQG 254
Cdd:cd23982  155 LCDEVHIAGF---------GYpdngnSNQPIHYYNQI 182
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 63-118 7.61e-10

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 58.34  E-value: 7.61e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 568922250  63 RTQEPLQlnCNHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMT 118
Cdd:cd23979   73 RSWDPSR--CRRCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVGFEADVGSRT 126
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 71-122 6.23e-09

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 54.93  E-value: 6.23e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 568922250  71 NCNHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMTMVRV 122
Cdd:cd23981    1 SCRRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRI 52
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 72-130 8.25e-09

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 54.74  E-value: 8.25e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 568922250  72 CNHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMTMVRVVSHTSVPL 130
Cdd:cd23983    2 CRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMTYPEGAPK 60
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 14-255 1.32e-08

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 55.21  E-value: 1.32e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922250  14 CILLLAMRLVNDATFPLLLNcFGQPKTKW--------------IPLPYTFR--------QPLRTHYGYINVRTQEPLQL- 70
Cdd:cd23972    1 CPHSLHLRIQRDPHFRGLFN-FDIPVLLWgqhftpalwdrlsqRKVPYGWKglshqvvaSTLSLLNDSANAKLFFPRDTp 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922250  71 -NCNHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMT-------------MVRVVSH--TSVPlLLKN 134
Cdd:cd23972   80 gKCIRCAVVGNGGILNGSRQGRAIDAHDYVFRLNGAVIKGFEEDVGTKTsfygftvntmknsLISYWNLgfTRTP-QGQD 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922250 135 PDYFFKEASRTIYVI-----------------------WGPFRNMRKdgngivYNMLkktvdaYPDAQIYVTteqqmthc 191
Cdd:cd23972  159 LQYIFIPSDIRDYVMlrsailgvpvpegldkgdrphkyFGPEASAKK------FKLL------HPDFISYLT-------- 218

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568922250 192 DRVFKDETGKDRVQSGSYLSTGWFTFILAMDACYSIHVYGMInetyckTEGYRKVPYHYYEQGK 255
Cdd:cd23972  219 DRFLKSKLLNTHYGHLYMPSTGALMLLTALHTCDQVSAYGFI------TSNYWKFSDHYYERKK 276
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 73-255 1.68e-08

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 54.34  E-value: 1.68e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922250  73 NHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVG----YMTMVRVVSHTSVPLLLKNPDY-FFKEASRTIY 147
Cdd:cd23969   65 RTCAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPVEGYEKDVGtksnLTTMNPSVIPHAYGDLVNATDKeKFVERLRQLG 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922250 148 --VIWGP-FrnMRKDG-------NGIVYNMLKKTVDAYPDAqiyvtteqQMTHCDRVFKDETgKDRVQSGsylSTGWFTF 217
Cdd:cd23969  145 dsILWIPaF--VSKGGeehvqwtNEIILKHKLNVKTAYPPL--------RLNHAIRGYWLTT-KFRIKRP---STGLLMY 210

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 568922250 218 ILAMDACYSIHVYGMIneTYCKTEGYRKVPYHYYEQGK 255
Cdd:cd23969  211 TLATRFCDEIHLYGFY--PFSEDGNGRAVKYHYYDNRK 246
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 73-255 2.34e-08

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 54.19  E-value: 2.34e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922250  73 NHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVG----YMTMVRVVSHTSVPLLLKNPD---YFFKEASRT 145
Cdd:cd23988   65 KTCAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVVEFAADVGtksdFITMNPSVVQRAFGGFRNESDrekFVHRLSMLN 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922250 146 IYVIWGPfRNMRKDG-------NGIVYNMLKKTVDAYPDAqiyvtteqQMTHCDRVFKdETGKDRVQSGsylSTGWFTFI 218
Cdd:cd23988  145 DSVLWIP-AFMVKGGekhvewvNALILKNKLKVRTAYPSL--------RLIHAVRGYW-LTNKVNIKRP---STGLLMYT 211

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 568922250 219 LAMDACYSIHVYGMIneTYCKTEGYRKVPYHYYEQGK 255
Cdd:cd23988  212 LATRFCDEIHLYGFW--PFPKDANGNPVKYHYYDDLK 246
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 72-121 1.25e-07

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 51.29  E-value: 1.25e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 568922250  72 CNHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMTMVR 121
Cdd:cd23984    2 CKKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFR 51
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 71-118 4.71e-07

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 50.52  E-value: 4.71e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 568922250  71 NCNHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMT 118
Cdd:cd23974   83 PCIRCAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITKGFEKDVGRRT 130
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 75-252 1.53e-05

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 45.70  E-value: 1.53e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922250  75 CAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVG----YMTMVRVVSHTSVPLLLKNP--DYFFKE-ASRTIY 147
Cdd:cd23987   67 CAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEEYAKDVGtktdLVTMNPSVVQRAFEDLVNETwkEKFLQRlQSLNGS 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922250 148 VIWGPfRNMRKDGNGIVY----NMLKKTVD---AYPDAqiyvtteqQMTHCDRVFKdETGKDRVQSGsylSTGWFTFILA 220
Cdd:cd23987  147 ILWIP-AFMAKGGEERVEwvndLILKHHINvrtAYPSL--------RLLHAVRGYW-LTNKVHIKRP---TTGLLMYTLA 213

                        170       180       190
                 ....*....|....*....|....*....|..
gi 568922250 221 MDACYSIHVYGMIneTYCKTEGYRKVPYHYYE 252
Cdd:cd23987  214 TRFCNRIHLYGFW--PFPRDQNQNPVKYHYYD 243
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 67-252 3.69e-05

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 44.44  E-value: 3.69e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922250  67 PLQLNCNHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAP-TKGFEEDVGYMTMVRVVSHTSVPLLLKNPDYffkeaSRT 145
Cdd:cd23989   58 PLQLPLKKCSVVGNGGILKNSGCGQQIDRADFVMRCNLPPlSREYTDDVGTKTQLVTANPSIIDKRFQNLLW-----SRK 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922250 146 IYViwgpfRNMRKDGNGIVYN---MLKKTVDayPDAQIYVT-----TEQQMTHCDRVFKDETG---KDRVQSGSYLSTGW 214
Cdd:cd23989  133 SFV-----ESMKVYGRSYIYMpafSMKTGTD--PSLRVYYTladvgANQTVLFANPNFLRNVGkfwKSKGVHAKRLSTGL 205

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 568922250 215 FTFILAMDACYSIHVYGMIneTYCKTEGYRKVPYHYYE 252
Cdd:cd23989  206 FLVSAALGLCEEVTIYGFW--PFSVDLDERTISHHYYD 241
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 73-118 3.58e-04

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 41.28  E-value: 3.58e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 568922250  73 NHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKG-FEEDVGYMT 118
Cdd:cd23991   65 KQCAVVGNGGILKNSSCGAEIDQADFVFRCNLPPTGGnISKDVGSKT 111
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 73-118 9.93e-04

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 39.93  E-value: 9.93e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 568922250  73 NHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKgFEEDVGYMT 118
Cdd:cd23971   65 KTCAVVGNGGILKNSSCGREIDSADFVIRCNLPPLN-DSKDVGSKT 109
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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