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Conserved domains on  [gi|568915596|ref|XP_006498889|]
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potassium voltage-gated channel subfamily H member 7 isoform X9 [Mus musculus]

Protein Classification

PAS and Ion_trans domain-containing protein( domain architecture ID 12140962)

PAS and Ion_trans domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 417-679 4.99e-32

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 124.69  E-value: 4.99e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568915596  417 VWDWLILLLVIYTAIFTPYSAAFLLNDReeqkrrecgySCSPLNVVDLIVDIMFIIDILINFRTTYVNqneevvsdpaki 496
Cdd:pfam00520   3 YFELFILLLILLNTIFLALETYFQPEEP----------LTTVLEILDYVFTGIFTLEMLLKIIAAGFK------------ 60

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568915596  497 aIHYFK-GWFLIDMVAAIPFDLLIFGSGSdETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVL--MLLMCIFALIAHW 573
Cdd:pfam00520  61 -KRYFRsPWNILDFVVVLPSLISLVLSSV-GSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIrsLKSLGNLLLLLLL 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568915596  574 LACIWYAIGNverpyltdkigwldslgtQIGKRYNDSDSSSGPSIK--DKYVTALYFTFSSLTSVGFGNVSPNTNSEK-- 649
Cdd:pfam00520 139 FLFIFAIIGY------------------QLFGGKLKTWENPDNGRTnfDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKge 200

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 568915596  650 -----IFSICVMLIGSLMYASIFGNVSAIIQRLYS 679
Cdd:pfam00520 201 fwayiYFVSFIILGGFLLLNLFIAVIIDNFQELTE 235
PAS_9 pfam13426
PAS domain; This domain is found in many signalling proteins in which it functions as a sensor ...
 38-134 1.72e-20

PAS domain; This domain is found in many signalling proteins in which it functions as a sensor domain. It recognizes FMN, Zn(II), FAD and riboflavin (MAtilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://0-doi-org.brum.beds.ac.uk/10.1093/femsre/fuab043).


:

Pssm-ID: 463873 [Multi-domain]  Cd Length: 93  Bit Score: 86.75  E-value: 1.72e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568915596   38 NCAIIYCNDGFCEMTGFSRPDVMQKPCTcDFLHGPETKRHDIAQIAQallGSEERKVEVTYYHKNGSTFICNTHIIPVKN 117
Cdd:pfam13426   1 DGRIIYVNDAALRLLGYTREELLGKSIT-DLFAEPEDSERLREALRE---GKAVREFEVVLYRKDGEPFPVLVSLAPIRD 76

                          90
                  ....*....|....*..
gi 568915596  118 QEGVAMMFIINFEYVTD 134
Cdd:pfam13426  77 DGGELVGIIAILRDITE 93
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 417-679 4.99e-32

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 124.69  E-value: 4.99e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568915596  417 VWDWLILLLVIYTAIFTPYSAAFLLNDReeqkrrecgySCSPLNVVDLIVDIMFIIDILINFRTTYVNqneevvsdpaki 496
Cdd:pfam00520   3 YFELFILLLILLNTIFLALETYFQPEEP----------LTTVLEILDYVFTGIFTLEMLLKIIAAGFK------------ 60

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568915596  497 aIHYFK-GWFLIDMVAAIPFDLLIFGSGSdETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVL--MLLMCIFALIAHW 573
Cdd:pfam00520  61 -KRYFRsPWNILDFVVVLPSLISLVLSSV-GSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIrsLKSLGNLLLLLLL 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568915596  574 LACIWYAIGNverpyltdkigwldslgtQIGKRYNDSDSSSGPSIK--DKYVTALYFTFSSLTSVGFGNVSPNTNSEK-- 649
Cdd:pfam00520 139 FLFIFAIIGY------------------QLFGGKLKTWENPDNGRTnfDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKge 200

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 568915596  650 -----IFSICVMLIGSLMYASIFGNVSAIIQRLYS 679
Cdd:pfam00520 201 fwayiYFVSFIILGGFLLLNLFIAVIIDNFQELTE 235
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 418-711 3.01e-24

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 108.80  E-value: 3.01e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568915596 418 WDWLILLLVIYTAIFTPYSAAFLlndREEQKRRecgyscspLNVVDLIVDIMFIIDILINFRTTYVNQNEEV-VSDPAKI 496
Cdd:PLN03192  64 WETLMVVLVAYSAWVYPFEVAFL---NASPKRG--------LEIADNVVDLFFAVDIVLTFFVAYIDPRTQLlVRDRKKI 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568915596 497 AIHYFKGWFLIDMVAAIPFD---LLIFG-SGSDETTTLIGLLKTARLLRLVRVARKLD---RYSEYGAAVLMLLmCIFAL 569
Cdd:PLN03192 133 AVRYLSTWFLMDVASTIPFQalaYLITGtVKLNLSYSLLGLLRFWRLRRVKQLFTRLEkdiRFSYFWIRCARLL-SVTLF 211

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568915596 570 IAHWLACIWYAIGNverPYLTDKIGWLDSLGTQIGKryndsdsssgPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEK 649
Cdd:PLN03192 212 LVHCAGCLYYLIAD---RYPHQGKTWIGAVIPNFRE----------TSLWIRYISAIYWSITTMTTVGYGDLHAVNTIEM 278

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568915596 650 IFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHMQMLRVKEFIRFHQIPNPLRQRLEEY 711
Cdd:PLN03192 279 IFIIFYMLFNLGLTAYLIGNMTNLVVEGTRRTMEFRNSIEAASNFVGRNRLPPRLKDQILAY 340
PAS_9 pfam13426
PAS domain; This domain is found in many signalling proteins in which it functions as a sensor ...
 38-134 1.72e-20

PAS domain; This domain is found in many signalling proteins in which it functions as a sensor domain. It recognizes FMN, Zn(II), FAD and riboflavin (MAtilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://0-doi-org.brum.beds.ac.uk/10.1093/femsre/fuab043).


Pssm-ID: 463873 [Multi-domain]  Cd Length: 93  Bit Score: 86.75  E-value: 1.72e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568915596   38 NCAIIYCNDGFCEMTGFSRPDVMQKPCTcDFLHGPETKRHDIAQIAQallGSEERKVEVTYYHKNGSTFICNTHIIPVKN 117
Cdd:pfam13426   1 DGRIIYVNDAALRLLGYTREELLGKSIT-DLFAEPEDSERLREALRE---GKAVREFEVVLYRKDGEPFPVLVSLAPIRD 76

                          90
                  ....*....|....*..
gi 568915596  118 QEGVAMMFIINFEYVTD 134
Cdd:pfam13426  77 DGGELVGIIAILRDITE 93
PAS COG2202
PAS domain [Signal transduction mechanisms];
41-138 8.69e-15

PAS domain [Signal transduction mechanisms];


Pssm-ID: 441804 [Multi-domain]  Cd Length: 258  Bit Score: 75.06  E-value: 8.69e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568915596  41 IIYCNDGFCEMTGFSRPDVMQKpcTCDFLHGPETKRHDIAQIAQALLGSEERKVEVTYYHKNGSTFICNTHIIPVKNQEG 120
Cdd:COG2202   33 ILYVNPAFERLTGYSAEELLGK--TLRDLLPPEDDDEFLELLRAALAGGGVWRGELRNRRKDGSLFWVELSISPVRDEDG 110

                         90
                 ....*....|....*...
gi 568915596 121 VAMMFIINFEYVTDEENA 138
Cdd:COG2202  111 EITGFVGIARDITERKRA 128
PRK13557 PRK13557
histidine kinase; Provisional
 41-120 4.62e-12

histidine kinase; Provisional


Pssm-ID: 237425 [Multi-domain]  Cd Length: 540  Bit Score: 69.31  E-value: 4.62e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568915596  41 IIYCNDGFCEMTGFSRPDVMQKpcTCDFLHGPETKRHDIAQIAQALLGSEERKVEVTYYHKNGSTFICNTHIIPVKNQEG 120
Cdd:PRK13557  55 IVFANRAFLEMTGYAAEEIIGN--NCRFLQGPETDRATVAEVRDAIAERREIATEILNYRKDGSSFWNALFVSPVYNDAG 132
PAS cd00130
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 41-130 1.35e-10

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.


Pssm-ID: 238075 [Multi-domain]  Cd Length: 103  Bit Score: 58.80  E-value: 1.35e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568915596  41 IIYCNDGFCEMTGFSRPDVMQKPCTcDFLHGPETKRHdIAQIAQALLGSEERKVEVTYYHKNGSTFICNTHIIPVKNQEG 120
Cdd:cd00130   14 ILYANPAAEQLLGYSPEELIGKSLL-DLIHPEDREEL-RERLENLLSGGEPVTLEVRLRRKDGSVIWVLVSLTPIRDEGG 91

                         90
                 ....*....|
gi 568915596 121 VAMMFIINFE 130
Cdd:cd00130   92 EVIGLLGVVR 101
sensory_box TIGR00229
PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain ...
 41-138 3.55e-05

PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain occupies the central portion of the PAS domain but is more widely distributed. It is often tandemly repeated. Known prosthetic groups bound in the S-box domain include heme in the oxygen sensor FixL, FAD in the redox potential sensor NifL, and a 4-hydroxycinnamyl chromophore in photoactive yellow protein. Proteins containing the domain often contain other regulatory domains such as response regulator or sensor histidine kinase domains. Other S-box proteins include phytochromes and the aryl hydrocarbon receptor nuclear translocator. [Regulatory functions, Small molecule interactions]


Pssm-ID: 272971 [Multi-domain]  Cd Length: 124  Bit Score: 43.82  E-value: 3.55e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568915596   41 IIYCNDGFCEMTGFSRPDVMQKPCTcDFLHGPETKRHDiaQIAQALLGSEERKV--EVTYYHKNGSTFICNTHIIPVKNQ 118
Cdd:TIGR00229  25 ILYVNPAFEEIFGYSAEELIGRNVL-ELIPEEDREEVR--ERIERRLEGEPEPVseERRVRRKDGSEIWVEVSVSPIRTN 101

                          90       100
                  ....*....|....*....|..
gi 568915596  119 EGV--AMMFIINfeyVTDEENA 138
Cdd:TIGR00229 102 GGElgVVGIVRD---ITERKEA 120
PAS smart00091
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 41-73 2.04e-03

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.


Pssm-ID: 214512  Cd Length: 67  Bit Score: 37.38  E-value: 2.04e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 568915596    41 IIYCNDGFCEMTGFSRPDVMQKPCTcDFLHGPE 73
Cdd:smart00091  23 ILYANPAAEELLGYSPEELIGKSLL-ELIHPED 54
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 417-679 4.99e-32

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 124.69  E-value: 4.99e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568915596  417 VWDWLILLLVIYTAIFTPYSAAFLLNDReeqkrrecgySCSPLNVVDLIVDIMFIIDILINFRTTYVNqneevvsdpaki 496
Cdd:pfam00520   3 YFELFILLLILLNTIFLALETYFQPEEP----------LTTVLEILDYVFTGIFTLEMLLKIIAAGFK------------ 60

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568915596  497 aIHYFK-GWFLIDMVAAIPFDLLIFGSGSdETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVL--MLLMCIFALIAHW 573
Cdd:pfam00520  61 -KRYFRsPWNILDFVVVLPSLISLVLSSV-GSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIrsLKSLGNLLLLLLL 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568915596  574 LACIWYAIGNverpyltdkigwldslgtQIGKRYNDSDSSSGPSIK--DKYVTALYFTFSSLTSVGFGNVSPNTNSEK-- 649
Cdd:pfam00520 139 FLFIFAIIGY------------------QLFGGKLKTWENPDNGRTnfDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKge 200

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 568915596  650 -----IFSICVMLIGSLMYASIFGNVSAIIQRLYS 679
Cdd:pfam00520 201 fwayiYFVSFIILGGFLLLNLFIAVIIDNFQELTE 235
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 418-711 3.01e-24

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 108.80  E-value: 3.01e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568915596 418 WDWLILLLVIYTAIFTPYSAAFLlndREEQKRRecgyscspLNVVDLIVDIMFIIDILINFRTTYVNQNEEV-VSDPAKI 496
Cdd:PLN03192  64 WETLMVVLVAYSAWVYPFEVAFL---NASPKRG--------LEIADNVVDLFFAVDIVLTFFVAYIDPRTQLlVRDRKKI 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568915596 497 AIHYFKGWFLIDMVAAIPFD---LLIFG-SGSDETTTLIGLLKTARLLRLVRVARKLD---RYSEYGAAVLMLLmCIFAL 569
Cdd:PLN03192 133 AVRYLSTWFLMDVASTIPFQalaYLITGtVKLNLSYSLLGLLRFWRLRRVKQLFTRLEkdiRFSYFWIRCARLL-SVTLF 211

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568915596 570 IAHWLACIWYAIGNverPYLTDKIGWLDSLGTQIGKryndsdsssgPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEK 649
Cdd:PLN03192 212 LVHCAGCLYYLIAD---RYPHQGKTWIGAVIPNFRE----------TSLWIRYISAIYWSITTMTTVGYGDLHAVNTIEM 278

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568915596 650 IFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHMQMLRVKEFIRFHQIPNPLRQRLEEY 711
Cdd:PLN03192 279 IFIIFYMLFNLGLTAYLIGNMTNLVVEGTRRTMEFRNSIEAASNFVGRNRLPPRLKDQILAY 340
PAS_9 pfam13426
PAS domain; This domain is found in many signalling proteins in which it functions as a sensor ...
 38-134 1.72e-20

PAS domain; This domain is found in many signalling proteins in which it functions as a sensor domain. It recognizes FMN, Zn(II), FAD and riboflavin (MAtilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://0-doi-org.brum.beds.ac.uk/10.1093/femsre/fuab043).


Pssm-ID: 463873 [Multi-domain]  Cd Length: 93  Bit Score: 86.75  E-value: 1.72e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568915596   38 NCAIIYCNDGFCEMTGFSRPDVMQKPCTcDFLHGPETKRHDIAQIAQallGSEERKVEVTYYHKNGSTFICNTHIIPVKN 117
Cdd:pfam13426   1 DGRIIYVNDAALRLLGYTREELLGKSIT-DLFAEPEDSERLREALRE---GKAVREFEVVLYRKDGEPFPVLVSLAPIRD 76

                          90
                  ....*....|....*..
gi 568915596  118 QEGVAMMFIINFEYVTD 134
Cdd:pfam13426  77 DGGELVGIIAILRDITE 93
PAS COG2202
PAS domain [Signal transduction mechanisms];
41-138 8.69e-15

PAS domain [Signal transduction mechanisms];


Pssm-ID: 441804 [Multi-domain]  Cd Length: 258  Bit Score: 75.06  E-value: 8.69e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568915596  41 IIYCNDGFCEMTGFSRPDVMQKpcTCDFLHGPETKRHDIAQIAQALLGSEERKVEVTYYHKNGSTFICNTHIIPVKNQEG 120
Cdd:COG2202   33 ILYVNPAFERLTGYSAEELLGK--TLRDLLPPEDDDEFLELLRAALAGGGVWRGELRNRRKDGSLFWVELSISPVRDEDG 110

                         90
                 ....*....|....*...
gi 568915596 121 VAMMFIINFEYVTDEENA 138
Cdd:COG2202  111 EITGFVGIARDITERKRA 128
PRK13557 PRK13557
histidine kinase; Provisional
 41-120 4.62e-12

histidine kinase; Provisional


Pssm-ID: 237425 [Multi-domain]  Cd Length: 540  Bit Score: 69.31  E-value: 4.62e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568915596  41 IIYCNDGFCEMTGFSRPDVMQKpcTCDFLHGPETKRHDIAQIAQALLGSEERKVEVTYYHKNGSTFICNTHIIPVKNQEG 120
Cdd:PRK13557  55 IVFANRAFLEMTGYAAEEIIGN--NCRFLQGPETDRATVAEVRDAIAERREIATEILNYRKDGSSFWNALFVSPVYNDAG 132
PRK13558 PRK13558
bacterio-opsin activator; Provisional
 31-120 3.38e-11

bacterio-opsin activator; Provisional


Pssm-ID: 237426 [Multi-domain]  Cd Length: 665  Bit Score: 66.78  E-value: 3.38e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568915596  31 IANARVQNCAIIYCNDGFCEMTGFSRPDVMQKpcTCDFLHGPETKRHDIAQIAQALLGSEERKVEVTYYHKNGSTFICNT 110
Cdd:PRK13558 163 IADATLPDEPLIYINDAFERITGYSPDEVLGR--NCRFLQGEDTNEERVAELREAIDEERPTSVELRNYRKDGSTFWNQV 240

                         90
                 ....*....|
gi 568915596 111 HIIPVKNQEG 120
Cdd:PRK13558 241 DIAPIRDEDG 250
PRK13559 PRK13559
hypothetical protein; Provisional
 30-125 3.46e-11

hypothetical protein; Provisional


Pssm-ID: 237427 [Multi-domain]  Cd Length: 361  Bit Score: 65.61  E-value: 3.46e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568915596  30 IIANARVQNCAIIYCNDGFCEMTGFSRPDVMQKpcTCDFLHGPETKRHDIAQIAQALLGSEERKVEVTYYHKNGSTFICN 109
Cdd:PRK13559  57 CITDPHQPDLPIVLANQAFLDLTGYAAEEVVGR--NCRFLQGAATDPIAVAKIRAAIAAEREIVVELLNYRKDGEPFWNA 134

                         90
                 ....*....|....*.
gi 568915596 110 THIIPVKNQEGVAMMF 125
Cdd:PRK13559 135 LHLGPVYGEDGRLLYF 150
PAS cd00130
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 41-130 1.35e-10

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.


Pssm-ID: 238075 [Multi-domain]  Cd Length: 103  Bit Score: 58.80  E-value: 1.35e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568915596  41 IIYCNDGFCEMTGFSRPDVMQKPCTcDFLHGPETKRHdIAQIAQALLGSEERKVEVTYYHKNGSTFICNTHIIPVKNQEG 120
Cdd:cd00130   14 ILYANPAAEQLLGYSPEELIGKSLL-DLIHPEDREEL-RERLENLLSGGEPVTLEVRLRRKDGSVIWVLVSLTPIRDEGG 91

                         90
                 ....*....|
gi 568915596 121 VAMMFIINFE 130
Cdd:cd00130   92 EVIGLLGVVR 101
Ion_trans_2 pfam07885
Ion channel; This family includes the two membrane helix type ion channels found in bacteria.
 622-676 2.52e-10

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.


Pssm-ID: 462301 [Multi-domain]  Cd Length: 78  Bit Score: 57.28  E-value: 2.52e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 568915596  622 YVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQR 676
Cdd:pfam07885  24 FLDALYFSFVTLTTVGYGDIVPLTDAGRLFTIFYILIGIPLFAIFLAVLGRFLTE 78
PAS_3 pfam08447
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ...
 41-120 1.55e-07

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya.


Pssm-ID: 430001 [Multi-domain]  Cd Length: 89  Bit Score: 49.64  E-value: 1.55e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568915596   41 IIYCNDGFCEMTGFSRPDVMQKPCTC-DFLHgPETKRHDIAQIAQALLGSEERKVEVTYYHKNGSTFICNTHIIPVKNQE 119
Cdd:pfam08447   1 IIYWSPRFEEILGYTPEELLGKGESWlDLVH-PDDRERVREALWEALKGGEPYSGEYRIRRKDGEYRWVEARARPIRDEN 79


                  .
gi 568915596  120 G 120
Cdd:pfam08447  80 G 80
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
41-127 3.39e-07

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 52.93  E-value: 3.39e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568915596  41 IIYCNDGFCEMTGFSRPDVMQKPCTcDFLHGPETKRHDIAQIAQAllGSEERKVEVTYYHKNGSTFICNTHIIPVKNQEG 120
Cdd:COG3852   29 ITYVNPAAERLLGLSAEELLGRPLA-ELFPEDSPLRELLERALAE--GQPVTEREVTLRRKDGEERPVDVSVSPLRDAEG 105


                 ....*..
gi 568915596 121 VAMMFII 127
Cdd:COG3852  106 EGGVLLV 112
PAS pfam00989
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ...
 41-129 1.21e-05

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://0-doi-org.brum.beds.ac.uk/10.1093/femsre/fuab043).


Pssm-ID: 395786 [Multi-domain]  Cd Length: 113  Bit Score: 45.10  E-value: 1.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568915596   41 IIYCNDGFCEMTGFSRPDVMQKPCTCDFLHGPETKRHDIaqIAQALL-GSEERKVEVTYYHKNGSTFICNTHIIPVKNQE 119
Cdd:pfam00989  23 ILYVNAAAEELLGLSREEVIGKSLLDLIPEEDDAEVAEL--LRQALLqGEESRGFEVSFRVPDGRPRHVEVRASPVRDAG 100

                          90
                  ....*....|
gi 568915596  120 GVAMMFIINF 129
Cdd:pfam00989 101 GEILGFLGVL 110
sensory_box TIGR00229
PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain ...
 41-138 3.55e-05

PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain occupies the central portion of the PAS domain but is more widely distributed. It is often tandemly repeated. Known prosthetic groups bound in the S-box domain include heme in the oxygen sensor FixL, FAD in the redox potential sensor NifL, and a 4-hydroxycinnamyl chromophore in photoactive yellow protein. Proteins containing the domain often contain other regulatory domains such as response regulator or sensor histidine kinase domains. Other S-box proteins include phytochromes and the aryl hydrocarbon receptor nuclear translocator. [Regulatory functions, Small molecule interactions]


Pssm-ID: 272971 [Multi-domain]  Cd Length: 124  Bit Score: 43.82  E-value: 3.55e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568915596   41 IIYCNDGFCEMTGFSRPDVMQKPCTcDFLHGPETKRHDiaQIAQALLGSEERKV--EVTYYHKNGSTFICNTHIIPVKNQ 118
Cdd:TIGR00229  25 ILYVNPAFEEIFGYSAEELIGRNVL-ELIPEEDREEVR--ERIERRLEGEPEPVseERRVRRKDGSEIWVEVSVSPIRTN 101

                          90       100
                  ....*....|....*....|..
gi 568915596  119 EGV--AMMFIINfeyVTDEENA 138
Cdd:TIGR00229 102 GGElgVVGIVRD---ITERKEA 120
PAS COG2202
PAS domain [Signal transduction mechanisms];
41-127 7.27e-05

PAS domain [Signal transduction mechanisms];


Pssm-ID: 441804 [Multi-domain]  Cd Length: 258  Bit Score: 45.02  E-value: 7.27e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568915596  41 IIYCNDGFCEMTGFSRPDVMQKPCTcDFLHgPETKRHDIAQIAQAL-LGSEERKVEVTYYHKNGSTFICNTHIIPVKNQE 119
Cdd:COG2202  159 ILYVNPAAEELLGYSPEELLGKSLL-DLLH-PEDRERLLELLRRLLeGGRESYELELRLKDGDGRWVWVEASAVPLRDGG 236


                 ....*...
gi 568915596 120 GVAMMFII 127
Cdd:COG2202  237 EVIGVLGI 244
PRK10537 PRK10537
voltage-gated potassium channel protein;
616-695 8.98e-05

voltage-gated potassium channel protein;


Pssm-ID: 236711 [Multi-domain]  Cd Length: 393  Bit Score: 45.40  E-value: 8.98e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568915596 616 PSIKDkYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYA----SIFGNV-SAIIQRLYSGTARyhmQMLR 690
Cdd:PRK10537 164 PPIES-LSTAFYFSIVTMSTVGYGDIVPVSESARLFTISVIILGITVFAtsisAIFGPViRGNLKRLVKGRIS---HMHR 239


                 ....*
gi 568915596 691 VKEFI 695
Cdd:PRK10537 240 KDHFI 244
PAS smart00091
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 41-73 2.04e-03

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.


Pssm-ID: 214512  Cd Length: 67  Bit Score: 37.38  E-value: 2.04e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 568915596    41 IIYCNDGFCEMTGFSRPDVMQKPCTcDFLHGPE 73
Cdd:smart00091  23 ILYANPAAEELLGYSPEELIGKSLL-ELIHPED 54
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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