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Conserved domains on  [gi|568914203|ref|XP_006498348|]
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cip1-interacting zinc finger protein isoform X17 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK10263 super family cl35903
DNA translocase FtsK; Provisional
 152-341 1.35e-07

DNA translocase FtsK; Provisional


The actual alignment was detected with superfamily member PRK10263:

Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 55.48  E-value: 1.35e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914203  152 TGQPQARVQPQTQMTAPKQTQTPDRLPEPPEVQMLPRIQPQALQIQTQPkllrqaqtqtSPEHLAPQQDQVEPQVPSQPP 231
Cdd:PRK10263  327 TTATQSWAAPVEPVTQTPPVASVDVPPAQPTVAWQPVPGPQTGEPVIAP----------APEGYPQQSQYAQPAVQYNEP 396

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914203  232 WQlQPRETDPPNQAQAQTQPQPLWQAQSQKQAQTQAHPQVPTQAQSQEQTSEKTQDQPQTWPQGSVPPPEQASGPACATE 311
Cdd:PRK10263  397 LQ-QPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQSTFAPQSTYQTEQTYQQPAAQE 475

                         170       180       190
                  ....*....|....*....|....*....|
gi 568914203  312 PQlsSHAAEAGSDPDKALPEPVSAQSSEDR 341
Cdd:PRK10263  476 PL--YQQPQPVEQQPVVEPEPVVEETKPAR 503
zf-C2H2_jaz pfam12171
Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, ...
 510-534 3.47e-05

Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localize in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localization.


:

Pssm-ID: 432381 [Multi-domain]  Cd Length: 27  Bit Score: 41.00  E-value: 3.47e-05
                          10        20
                  ....*....|....*....|....*
gi 568914203  510 FCTICNRYFKTPRKFVEHVKSQGHK 534
Cdd:pfam12171   3 YCVLCDKYFKSENALQNHLKSKKHK 27
GIY-YIG_SF super family cl15257
GIY-YIG nuclease domain superfamily; The GIY-YIG nuclease domain superfamily includes a large ...
 479-546 2.42e-03

GIY-YIG nuclease domain superfamily; The GIY-YIG nuclease domain superfamily includes a large and diverse group of proteins involved in many cellular processes, such as class I homing GIY-YIG family endonucleases, prokaryotic nucleotide excision repair proteins UvrC and Cho, type II restriction enzymes, the endonuclease/reverse transcriptase of eukaryotic retrotransposable elements, and a family of eukaryotic enzymes that repair stalled replication forks. All of these members contain a conserved GIY-YIG nuclease domain that may serve as a scaffold for the coordination of a divalent metal ion required for catalysis of the phosphodiester bond cleavage. By combining with different specificity, targeting, or other domains, the GIY-YIG nucleases may perform different functions.


The actual alignment was detected with superfamily member cd10442:

Pssm-ID: 472790  Cd Length: 92  Bit Score: 37.73  E-value: 2.42e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914203 479 WCNTCQVYYVGDLIQ--HRRTQEHKVAKQSlrpfcticNRYFKTPrkFVEHVKSQGHKDKAQELKTLEKE 546
Cdd:cd10442    6 PCPKCGLVYIGETKRplRERMKEHRRAIRL--------SGTKKSA--VAKHFNEEGHSIDSDRVRILDKE 65
ZnF_U1 smart00451
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ...
 626-659 2.86e-03

U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.


:

Pssm-ID: 197732 [Multi-domain]  Cd Length: 35  Bit Score: 35.69  E-value: 2.86e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 568914203   626 GYVCQICHKFYDSNSELRlSHCKSLAHFENLQKY 659
Cdd:smart00451   3 GFYCKLCNVTFTDEISVE-AHLKGKKHKKNVKKR 35
 
Name Accession Description Interval E-value
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 152-341 1.35e-07

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 55.48  E-value: 1.35e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914203  152 TGQPQARVQPQTQMTAPKQTQTPDRLPEPPEVQMLPRIQPQALQIQTQPkllrqaqtqtSPEHLAPQQDQVEPQVPSQPP 231
Cdd:PRK10263  327 TTATQSWAAPVEPVTQTPPVASVDVPPAQPTVAWQPVPGPQTGEPVIAP----------APEGYPQQSQYAQPAVQYNEP 396

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914203  232 WQlQPRETDPPNQAQAQTQPQPLWQAQSQKQAQTQAHPQVPTQAQSQEQTSEKTQDQPQTWPQGSVPPPEQASGPACATE 311
Cdd:PRK10263  397 LQ-QPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQSTFAPQSTYQTEQTYQQPAAQE 475

                         170       180       190
                  ....*....|....*....|....*....|
gi 568914203  312 PQlsSHAAEAGSDPDKALPEPVSAQSSEDR 341
Cdd:PRK10263  476 PL--YQQPQPVEQQPVVEPEPVVEETKPAR 503
zf-C2H2_jaz pfam12171
Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, ...
 510-534 3.47e-05

Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localize in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localization.


Pssm-ID: 432381 [Multi-domain]  Cd Length: 27  Bit Score: 41.00  E-value: 3.47e-05
                          10        20
                  ....*....|....*....|....*
gi 568914203  510 FCTICNRYFKTPRKFVEHVKSQGHK 534
Cdd:pfam12171   3 YCVLCDKYFKSENALQNHLKSKKHK 27
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 159-317 1.16e-04

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 45.41  E-value: 1.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914203  159 VQPQTQMTAPKQTQTPdrlPEPPEVQMLPRIQPQALQIQTQPKllrQAQTQTSPEHLAPQQDQvePQVPSQPPWQLQpre 238
Cdd:pfam09770 199 VEAAMRAQAKKPAQQP---APAPAQPPAAPPAQQAQQQQQFPP---QIQQQQQPQQQPQQPQQ--HPGQGHPVTILQ--- 267

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914203  239 tDPPNQAQAQTQPQPLWQAQSQKQAQTQAHPQvPTQA----QSQEQTSEKTQDQPQTWPQGSVPPPEQASGPACATEPQL 314
Cdd:pfam09770 268 -RPQSPQPDPAQPSIQPQAQQFHQQPPPVPVQ-PTQIlqnpNRLSAARVGYPQNPQPGVQPAPAHQAHRQQGSFGRQAPI 345


                  ...
gi 568914203  315 SSH 317
Cdd:pfam09770 346 ITH 348
GIY-YIG_PLEs cd10442
Catalytic GIY-YIG endonuclease domain of penelope-like elements and similar proteins; This ...
 479-546 2.42e-03

Catalytic GIY-YIG endonuclease domain of penelope-like elements and similar proteins; This model corresponds to the EN domain of PLEs that contains catalytic module of the GIY-YIG endonucleases of group I bacterial/organellar introns, as well as bacterial UvrC DNA repair proteins. It can cleave DNA with low nucleotide sequence specificity. However, the PLEs EN domain is distinct from other GIY-YIG endonucleases by the presence of a well-conserved CCHH motif (CX(2-7)CX(33-39)HX(3-5)H, X can be any residue). The role of the CCHH motif has not yet been identified. Penelope-like elements (PLEs) represent a novel class of eukaryotic retroelements, which do not belong to either long terminal repeat (LTR) retrotransposons or non-LTR retrotransposons (often called LINEs), but instead form a sister clade to telomerase reverse transcriptases (TERTs), highly specialized non-mobile reverse transcriptases (RTs) which are responsible for the addition of telomeric repeats to the ends of eukaryotic chromosomes. The single open reading frame (ORF) encoded by PLE consists of two principal domains, RT domain and endonuclease (EN) domain, jointed by a linker region of variable length. Both of these two domains are functionally active.


Pssm-ID: 198389  Cd Length: 92  Bit Score: 37.73  E-value: 2.42e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914203 479 WCNTCQVYYVGDLIQ--HRRTQEHKVAKQSlrpfcticNRYFKTPrkFVEHVKSQGHKDKAQELKTLEKE 546
Cdd:cd10442    6 PCPKCGLVYIGETKRplRERMKEHRRAIRL--------SGTKKSA--VAKHFNEEGHSIDSDRVRILDKE 65
ZnF_U1 smart00451
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ...
 626-659 2.86e-03

U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.


Pssm-ID: 197732 [Multi-domain]  Cd Length: 35  Bit Score: 35.69  E-value: 2.86e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 568914203   626 GYVCQICHKFYDSNSELRlSHCKSLAHFENLQKY 659
Cdd:smart00451   3 GFYCKLCNVTFTDEISVE-AHLKGKKHKKNVKKR 35
 
Name Accession Description Interval E-value
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 152-341 1.35e-07

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 55.48  E-value: 1.35e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914203  152 TGQPQARVQPQTQMTAPKQTQTPDRLPEPPEVQMLPRIQPQALQIQTQPkllrqaqtqtSPEHLAPQQDQVEPQVPSQPP 231
Cdd:PRK10263  327 TTATQSWAAPVEPVTQTPPVASVDVPPAQPTVAWQPVPGPQTGEPVIAP----------APEGYPQQSQYAQPAVQYNEP 396

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914203  232 WQlQPRETDPPNQAQAQTQPQPLWQAQSQKQAQTQAHPQVPTQAQSQEQTSEKTQDQPQTWPQGSVPPPEQASGPACATE 311
Cdd:PRK10263  397 LQ-QPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQSTFAPQSTYQTEQTYQQPAAQE 475

                         170       180       190
                  ....*....|....*....|....*....|
gi 568914203  312 PQlsSHAAEAGSDPDKALPEPVSAQSSEDR 341
Cdd:PRK10263  476 PL--YQQPQPVEQQPVVEPEPVVEETKPAR 503
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 141-352 2.10e-06

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 51.14  E-value: 2.10e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914203 141 ASSEESTEKGPTGQPQARVQPQ--TQMTAPKQTQTPDRLPEPPEVQMLPRIQPQALQIQTQPKLLRQAQTQTSPEHLAPQ 218
Cdd:PRK07764 595 AGGEGPPAPASSGPPEEAARPAapAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAG 674

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914203 219 QDQVEPQVPSQPPWQLQPRETDPPNQAQAQTQpqplWQAQSQKQAQTQAHPQVPTQAQSQEQTSEKTQ----DQPQTWPQ 294
Cdd:PRK07764 675 GAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPA----ATPPAGQADDPAAQPPQAAQGASAPSPAADDPvplpPEPDDPPD 750

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 568914203 295 GSVPPPEQASGPACATEPQLSSHAAEA-GSDPDKALPEPVSAQSSEDRsREASAGGLDL 352
Cdd:PRK07764 751 PAGAPAQPPPPPAPAPAAAPAAAPPPSpPSEEEEMAEDDAPSMDDEDR-RDAEEVAMEL 808
PHA03247 PHA03247
large tegument protein UL36; Provisional
 141-347 1.49e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.78  E-value: 1.49e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914203  141 ASSEESTEKGPTgqPQARVQPQTQMTAPKQTQTPDRLP---EPPEVQMLPRIQPQALQIQTQPKLLRQAQTQTSP--EHL 215
Cdd:PHA03247 2789 ASLSESRESLPS--PWDPADPPAAVLAPAAALPPAASPagpLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDvrRRP 2866

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914203  216 APQQDQVEPQVPSQPPWQLQPRETDPPNQAQAQTQPQPLwQAQSQKQAQTQAHPQVPTQAQSQEQTSEKTQDQPQtwpqg 295
Cdd:PHA03247 2867 PSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQP-ERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQ----- 2940

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 568914203  296 svPPPEQASGPACATEPQLSSHAAEAGSDPDKALPEPVSAQSSEDRSREASA 347
Cdd:PHA03247 2941 --PPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPA 2990
zf-C2H2_jaz pfam12171
Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, ...
 510-534 3.47e-05

Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localize in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localization.


Pssm-ID: 432381 [Multi-domain]  Cd Length: 27  Bit Score: 41.00  E-value: 3.47e-05
                          10        20
                  ....*....|....*....|....*
gi 568914203  510 FCTICNRYFKTPRKFVEHVKSQGHK 534
Cdd:pfam12171   3 YCVLCDKYFKSENALQNHLKSKKHK 27
PRK14949 PRK14949
DNA polymerase III subunits gamma and tau; Provisional
 142-289 3.50e-05

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237863 [Multi-domain]  Cd Length: 944  Bit Score: 47.41  E-value: 3.50e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914203 142 SSEESTEKGPTGQPQARVQPQTQmTAPKQTQTPDRLPEPPEVQMLPR--IQPQALQIQTQPKLLRQAQTQTSPEHLAPQQ 219
Cdd:PRK14949 639 SSADRKPKTPPSRAPPASLSKPA-SSPDASQTSASFDLDPDFELATHqsVPEAALASGSAPAPPPVPDPYDRPPWEEAPE 717

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914203 220 DQVEPQVPSQPPwqlqpRETDPPNQAQAQTQPQPLWQAQSQKQAQTQAHPQVPTQAQSQEQTSEKTQDQP 289
Cdd:PRK14949 718 VASANDGPNNAA-----EGNLSESVEDASNSELQAVEQQATHQPQVQAEAQSPASTTALTQTSSEVQDTE 782
PRK10927 PRK10927
cell division protein FtsN;
145-303 3.91e-05

cell division protein FtsN;


Pssm-ID: 236797 [Multi-domain]  Cd Length: 319  Bit Score: 46.21  E-value: 3.91e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914203 145 ESTEKGPTGQPQARVQPQTQMTAPKQT---QTPDRLPEPPEVQMLPRIQPQALQIQTQPKLLRQAQTQTSPEHLAPQQDQ 221
Cdd:PRK10927 101 EPSAGGEVKTPEQLTPEQRQLLEQMQAdmrQQPTQLVEVPWNEQTPEQRQQTLQRQRQAQQLAEQQRLAQQSRTTEQSWQ 180

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914203 222 VEPQVPSQPPWQLQPRetdPPNQAQAQTQPQPLWQAQSQKQAQTQAHPQVPT--QAQSQEQTSEKTQDQPQTWPQGSVPP 299
Cdd:PRK10927 181 QQTRTSQAAPVQAQPR---QSKPASTQQPYQDLLQTPAHTTAQSKPQQAAPVtrAADAPKPTAEKKDERRWMVQCGSFRG 257


                 ....
gi 568914203 300 PEQA 303
Cdd:PRK10927 258 AEQA 261
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 180-300 1.01e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 45.85  E-value: 1.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914203  180 PPEVQMLPRIQPQAlqiQTQPKLLRQAQTQTSPEHLAPQQDQVEPQVPSQPPWQLQPRETDPPNQAQAqtqpqplwqAQS 259
Cdd:PRK10263  740 PHEPLFTPIVEPVQ---QPQQPVAPQQQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQY---------QQP 807

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 568914203  260 QKQAQTQAHPQVPTQAQSQEQTSEKTQDQPQTWPQGSVPPP 300
Cdd:PRK10263  808 QQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQDTLLHP 848
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 159-317 1.16e-04

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 45.41  E-value: 1.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914203  159 VQPQTQMTAPKQTQTPdrlPEPPEVQMLPRIQPQALQIQTQPKllrQAQTQTSPEHLAPQQDQvePQVPSQPPWQLQpre 238
Cdd:pfam09770 199 VEAAMRAQAKKPAQQP---APAPAQPPAAPPAQQAQQQQQFPP---QIQQQQQPQQQPQQPQQ--HPGQGHPVTILQ--- 267

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914203  239 tDPPNQAQAQTQPQPLWQAQSQKQAQTQAHPQvPTQA----QSQEQTSEKTQDQPQTWPQGSVPPPEQASGPACATEPQL 314
Cdd:pfam09770 268 -RPQSPQPDPAQPSIQPQAQQFHQQPPPVPVQ-PTQIlqnpNRLSAARVGYPQNPQPGVQPAPAHQAHRQQGSFGRQAPI 345


                  ...
gi 568914203  315 SSH 317
Cdd:pfam09770 346 ITH 348
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 149-294 1.60e-04

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 45.03  E-value: 1.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914203  149 KGPTGQPQARVQPQTQMTAPKQTQTPDRLPEPPEVQMLPRIQPQALQIQTQ----PKLLRQAQTQTSPEHLAPQQDQVEP 224
Cdd:pfam09770 208 KKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHPGqghpVTILQRPQSPQPDPAQPSIQPQAQQ 287

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568914203  225 QVPSQPPWQLQPRETDP-PNQAQAQTQPQPlwqaqsqkQAQTQAHPQVPTQAQSQEQTSEKTQDQPQTWPQ 294
Cdd:pfam09770 288 FHQQPPPVPVQPTQILQnPNRLSAARVGYP--------QNPQPGVQPAPAHQAHRQQGSFGRQAPIITHPQ 350
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 154-239 1.90e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 45.08  E-value: 1.90e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914203  154 QPQARVQPQTQMTAPKQTQTPDRLPEPPEVQMLPRIQPQALQIQTQPkllrQAQTQTSPEHLAPQQDQVEPQVPSQPpwq 233
Cdd:PRK10263  767 QPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAP----QPQYQQPQQPVAPQPQYQQPQQPVAP--- 839


                  ....*.
gi 568914203  234 lQPRET 239
Cdd:PRK10263  840 -QPQDT 844
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 151-283 1.95e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 44.86  E-value: 1.95e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914203 151 PTGQPQARVQPQTQMTAPKQTQTPdrlPEPPEVQMLPRIQPQALQIQTQpklLRQAQTQTSPEHLAPQQDQVEPQVPSQP 230
Cdd:PRK07994 383 ATAAPTAAVAPPQAPAVPPPPASA---PQQAPAVPLPETTSQLLAARQQ---LQRAQGATKAKKSEPAAASRARPVNSAL 456

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 568914203 231 PW--QLQPRETDPPNQAQAQTQPQPLWQAQSQKQAQTQAHPQVPTQAQSQEQTSE 283
Cdd:PRK07994 457 ERlaSVRPAPSALEKAPAKKEAYRWKATNPVEVKKEPVATPKALKKALEHEKTPE 511
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 151-280 3.98e-04

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 43.87  E-value: 3.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914203  151 PTGQPQARVQPQTQmtAPKQTQTPDRLPEPPEVQMLPRIQPQALQIQTQPKLLRQAQTQTSPEHLAPQQDQVEPQVPSQP 230
Cdd:pfam09770 222 PAAPPAQQAQQQQQ--FPPQIQQQQQPQQQPQQPQQHPGQGHPVTILQRPQSPQPDPAQPSIQPQAQQFHQQPPPVPVQP 299

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568914203  231 PWQLQ-------PRETDPPNQAQAQTQPQPLWQAQSQ----KQAQTQAHPQVPTQAQSQEQ 280
Cdd:pfam09770 300 TQILQnpnrlsaARVGYPQNPQPGVQPAPAHQAHRQQgsfgRQAPIITHPQQLAQLSEEEK 360
PHA03247 PHA03247
large tegument protein UL36; Provisional
 93-348 5.47e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 5.47e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914203   93 GPDSMLSEPQVPEPEPFETLEPPAKRCRRVRIKGIDHHnwlfaylwiFASSEESTEKGPTGQPQARVQPQTQMTAPKQTQ 172
Cdd:PHA03247 2860 GDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTES---------FALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQ 2930

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914203  173 TPDRLPEPPEVQMLPRIQPQAlQIQTQPKLLRQAQTQTSPEHLAPQQDQVEPQVPSQPpwqlQPRETDPPNQAQAQTQPQ 252
Cdd:PHA03247 2931 PPPPPPPRPQPPLAPTTDPAG-AGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSRE----APASSTPPLTGHSLSRVS 3005

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914203  253 PlWQAQSQKQAQTQAHP-------QVPTQAQSQEQTSEKTQDqPQTWPQGSVPPPEQASGPACATEPQLSSHAAEAGSDP 325
Cdd:PHA03247 3006 S-WASSLALHEETDPPPvslkqtlWPPDDTEDSDADSLFDSD-SERSDLEALDPLPPEPHDPFAHEPDPATPEAGARESP 3083

                         250       260
                  ....*....|....*....|....
gi 568914203  326 DKAL-PEPVSAQSSEDRSREASAG 348
Cdd:PHA03247 3084 SSQFgPPPLSANAALSRRYVRSTG 3107
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 151-242 9.05e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 42.76  E-value: 9.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914203  151 PTGQPQARVQPQTQMTAPKQTQTPDRLPEPPEVQMLPRIQPQALQIQTQPkllrQAQTQTSPEHLAPQQDQVEPQVP--S 228
Cdd:PRK10263  751 PVQQPQQPVAPQQQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAP----QPQYQQPQQPVAPQPQYQQPQQPvaP 826

                          90
                  ....*....|....
gi 568914203  229 QPPWQlQPRETDPP 242
Cdd:PRK10263  827 QPQYQ-QPQQPVAP 839
GIY-YIG_PLEs cd10442
Catalytic GIY-YIG endonuclease domain of penelope-like elements and similar proteins; This ...
 479-546 2.42e-03

Catalytic GIY-YIG endonuclease domain of penelope-like elements and similar proteins; This model corresponds to the EN domain of PLEs that contains catalytic module of the GIY-YIG endonucleases of group I bacterial/organellar introns, as well as bacterial UvrC DNA repair proteins. It can cleave DNA with low nucleotide sequence specificity. However, the PLEs EN domain is distinct from other GIY-YIG endonucleases by the presence of a well-conserved CCHH motif (CX(2-7)CX(33-39)HX(3-5)H, X can be any residue). The role of the CCHH motif has not yet been identified. Penelope-like elements (PLEs) represent a novel class of eukaryotic retroelements, which do not belong to either long terminal repeat (LTR) retrotransposons or non-LTR retrotransposons (often called LINEs), but instead form a sister clade to telomerase reverse transcriptases (TERTs), highly specialized non-mobile reverse transcriptases (RTs) which are responsible for the addition of telomeric repeats to the ends of eukaryotic chromosomes. The single open reading frame (ORF) encoded by PLE consists of two principal domains, RT domain and endonuclease (EN) domain, jointed by a linker region of variable length. Both of these two domains are functionally active.


Pssm-ID: 198389  Cd Length: 92  Bit Score: 37.73  E-value: 2.42e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914203 479 WCNTCQVYYVGDLIQ--HRRTQEHKVAKQSlrpfcticNRYFKTPrkFVEHVKSQGHKDKAQELKTLEKE 546
Cdd:cd10442    6 PCPKCGLVYIGETKRplRERMKEHRRAIRL--------SGTKKSA--VAKHFNEEGHSIDSDRVRILDKE 65
PHA03247 PHA03247
large tegument protein UL36; Provisional
 11-312 2.43e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.46  E-value: 2.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914203   11 PQATRQSLLGPPPVGVPINPSqlnhsgrnTQKQARTPSSTTpnrkDSSSQTVPLEDREDPtEGSEEATELQMDTCEDQDS 90
Cdd:PHA03247 2561 PAAPDRSVPPPRPAPRPSEPA--------VTSRARRPDAPP----QSARPRAPVDDRGDP-RGPAPPSPLPPDTHAPDPP 2627

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914203   91 LVGPDSMLSEPQVPEPEPFETLEPP--------AKRCRRVRIKGidhhnwlfaylwiFASSEESTEKGPTgqPQARVQPQ 162
Cdd:PHA03247 2628 PPSPSPAANEPDPHPPPTVPPPERPrddpapgrVSRPRRARRLG-------------RAAQASSPPQRPR--RRAARPTV 2692

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914203  163 TQMTAPKQTQTPDRLPEPPevqmlPRIQPQALQIQTQPKLLRQAQTQTSPEHLAPQQDQ-----VEPQVPSQPPWQLQPR 237
Cdd:PHA03247 2693 GSLTSLADPPPPPPTPEPA-----PHALVSATPLPPGPAAARQASPALPAAPAPPAVPAgpatpGGPARPARPPTTAGPP 2767

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568914203  238 ETDPPNQAQAQTQPQPLWQAQSQKQAQTQAHPQVPTQAQSQEQTSEKTQDQPQTWPQGSVPPPEQASGPACATEP 312
Cdd:PHA03247 2768 APAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPP 2842
ZnF_U1 smart00451
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ...
 626-659 2.86e-03

U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.


Pssm-ID: 197732 [Multi-domain]  Cd Length: 35  Bit Score: 35.69  E-value: 2.86e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 568914203   626 GYVCQICHKFYDSNSELRlSHCKSLAHFENLQKY 659
Cdd:smart00451   3 GFYCKLCNVTFTDEISVE-AHLKGKKHKKNVKKR 35
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 153-418 4.22e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.52  E-value: 4.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914203  153 GQPQARVQPQTQMTAPKQTQTPDRLPEPPEVQMLPRIQPQALQIQTQpklLRQAQTQTSPEHL-APQQDQVEPQVPsqPP 231
Cdd:pfam03154 319 GQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHIKPPPTTPIPQ---LPNPQSHKHPPHLsGPSPFQMNSNLP--PP 393

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914203  232 WQLQPRETDPPNQAQAQTQPQPLWQAQSQKQAQTQAHPQVPTQAQSQEqtsektqdqpqtwPQGSVPPPEQASGPAcATE 311
Cdd:pfam03154 394 PALKPLSSLSTHHPPSAHPPPLQLMPQSQQLPPPPAQPPVLTQSQSLP-------------PPAASHPPTSGLHQV-PSQ 459

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914203  312 PQLSSHAAEAGSDPDKALPE--PVSAQSSEDRSREASAGGLDLGecekragemlGMWGAGSSLKVTILQSSNSRAFNTTP 389
Cdd:pfam03154 460 SPFPQHPFVPGGPPPITPPSgpPTSTSSAMPGIQPPSSASVSSS----------GPVPAAVSCPLPPVQIKEEALDEAEE 529

                         250       260       270
                  ....*....|....*....|....*....|.
gi 568914203  390 LTSGPRPGDSTSATPAIASTPS--KQSLQFF 418
Cdd:pfam03154 530 PESPPPPPRSPSPEPTVVNTPShaSQSARFY 560
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 148-333 6.58e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 40.06  E-value: 6.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914203 148 EKGPTGQPQARVQPQtqmtAPKQTQTPDRlPEPPEVQMLPRI--------QPQALQIQTQPKLLRQAQTQTSPEHLAPQQ 219
Cdd:PTZ00449 566 EHKPSKIPTLSKKPE----FPKDPKHPKD-PEEPKKPKRPRSaqrptrpkSPKLPELLDIPKSPKRPESPKSPKRPPPPQ 640

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914203 220 DQVEPQVPSQPPWQLQPRETDPPNQAQAQTQPQPLWQAQSQKQAQTQAHPQVPTQAQSQEQTSEKTQDQPQTWPQGSVP- 298
Cdd:PTZ00449 641 RPSSPERPEGPKIIKSPKPPKSPKPPFDPKFKEKFYDDYLDAAAKSKETKTTVVLDESFESILKETLPETPGTPFTTPRp 720

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 568914203 299 -PPEQASGPACATEPQlsshaaeagSDPDKALPEPV 333
Cdd:PTZ00449 721 lPPKLPRDEEFPFEPI---------GDPDAEQPDDI 747
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 146-302 8.80e-03

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 39.63  E-value: 8.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914203  146 STEKGPTGQPQARVQPQTQMTAPKQTQTPDR-------LPEP-PEVQMLPRI----------QPQALQIQTQPKLLRQ-- 205
Cdd:pfam09770 111 AAQSSAQPPASSLPQYQYASQQSQQPSKPVRtgyekykEPEPiPDLQVDASLwgvapkkaaaPAPAPQPAAQPASLPAps 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914203  206 ----------AQTQTSPEHLAPQQDQVEPQVPSQPPWQLQPRETDPPNQAQAQTQPQPlwQAQSQKQAQTQAHP-QVPTQ 274
Cdd:pfam09770 191 rkmmsleeveAAMRAQAKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQ--QPQQPQQHPGQGHPvTILQR 268

                         170       180
                  ....*....|....*....|....*...
gi 568914203  275 AQSQEQTSEKTQDQPQTWPQGSVPPPEQ 302
Cdd:pfam09770 269 PQSPQPDPAQPSIQPQAQQFHQQPPPVP 296
PRK10927 PRK10927
cell division protein FtsN;
156-311 9.04e-03

cell division protein FtsN;


Pssm-ID: 236797 [Multi-domain]  Cd Length: 319  Bit Score: 38.89  E-value: 9.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914203 156 QARVQPQTQMTAPKQTQTPDRLpEPPEVQMLPRIQPQALQIQTQpkLLRQAQTQTSPEHLAP--QQDQVEPQVPSQPPWQ 233
Cdd:PRK10927  93 QPGVRAPTEPSAGGEVKTPEQL-TPEQRQLLEQMQADMRQQPTQ--LVEVPWNEQTPEQRQQtlQRQRQAQQLAEQQRLA 169

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568914203 234 LQPRETDPPNQAQAQTQPqplwqaQSQKQAQTQAHPQVPTQAQSQE--QTSEKTQDQPQtwPQGSVPPPEQASGPACATE 311
Cdd:PRK10927 170 QQSRTTEQSWQQQTRTSQ------AAPVQAQPRQSKPASTQQPYQDllQTPAHTTAQSK--PQQAAPVTRAADAPKPTAE 241
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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