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Conserved domains on  [gi|568912824|ref|XP_006497690|]
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voltage-dependent N-type calcium channel subunit alpha-1B isoform X2 [Mus musculus]

Protein Classification

voltage-dependent calcium channel subunit alpha family protein( domain architecture ID 13634489)

voltage-dependent calcium channel subunit alpha family protein, similar to human P/Q-type calcium channel subunit alpha-1A

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1484-1733 4.20e-74

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 247.18  E-value: 4.20e-74
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912824  1484 SPPFEYFIMAMIALNTVVLMMKFYDAPYE-YELMLKCLNIVFTSMFSMECILKIIAFGV-LNYFRDAWNVFDFVTVLGSI 1561
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912824  1562 TDILVTEIaetNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIALD 1641
Cdd:pfam00520   81 ISLVLSSV---GSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912824  1642 DDTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLGnracdphanasECGSDFAYFYFVSFIFLCSFLMLNLFVAVI 1721
Cdd:pfam00520  158 WENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTID-----------GKGEFWAYIYFVSFIILGGFLLLNLFIAVI 226
                          250
                   ....*....|..
gi 568912824  1722 MDNFEYLTRDSS 1733
Cdd:pfam00520  227 IDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
94-367 2.78e-66

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 224.84  E-value: 2.78e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912824    94 WPPFEYMILATIIANCIVLALEQHLPDgdKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVFHkgsYLRNGWNVMDFVV 173
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQP--EEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVV 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912824   174 VLTGIL----ATAGTDFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKF 249
Cdd:pfam00520   76 VLPSLIslvlSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912824   250 HKacfpnstdtepvgdfpcgkdpparqcdgdtecreyWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGN 329
Cdd:pfam00520  156 KT-----------------------------------WENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGE 200
                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 568912824   330 TWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVE 367
Cdd:pfam00520  201 FWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
482-721 9.66e-56

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 194.41  E-value: 9.66e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912824   482 AQSFYWVVLCVVALNTLCVAMVHYNQPQ-RLTTALYFAEFVFLGLFLTEMSLKMYGLGP-RSYFRSSFNCFDFGVIVGSI 559
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEePLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912824   560 FEVVWAAIKPGtsFGISVLRALRLLRIFKVTKYWNSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQ 639
Cdd:pfam00520   81 ISLVLSSVGSL--SGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTW 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912824   640 DE--TPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGgvskGMFSSFYFIVLTLFGNYTLLNVFLAIAVDNLANAQ 717
Cdd:pfam00520  159 ENpdNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG----EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELT 234

                   ....
gi 568912824   718 ELTK 721
Cdd:pfam00520  235 ERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1160-1394 1.15e-54

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 191.33  E-value: 1.15e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912824  1160 RYFEMVILVVIALSSIALAAEDPVRTDSFRNNALKYMDYIFTGVFTFEMVIKMIDLGLLLHpgaYFRDLWNILDFIVVSG 1239
Cdd:pfam00520    2 RYFELFILLLILLNTIFLALETYFQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVVVLP 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912824  1240 ALVAFAFSSFMGGSkgkdinTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFK 1319
Cdd:pfam00520   79 SLISLVLSSVGSLS------GLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFG 152
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568912824  1320 GKFfyctdeskelerdcrgqyldyeKEEVEAQPRqwkkyDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATYE 1394
Cdd:pfam00520  153 GKL----------------------KTWENPDNG-----RTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGE 200
Ca_chan_IQ pfam08763
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
1806-1883 1.89e-41

Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).


:

Pssm-ID: 462591  Cd Length: 77  Bit Score: 147.36  E-value: 1.89e-41
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568912824  1806 TSTLMALIRTALEIKLAPAGtKQHQCDAELRKEISSVWANLPQKTLDLLVPPHKPDEMTVGKVYAALMIFDFYKQNKT 1883
Cdd:pfam08763    1 TATLFALIRTSLKIKLAPAG-EMDQADAELRKIIKKIWPRLSQKTLDLLVPPPSDDEMTVGKIYAALLIQDYYRQNKA 77
GPHH pfam16905
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
1742-1795 1.24e-31

Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.


:

Pssm-ID: 465306  Cd Length: 54  Bit Score: 118.52  E-value: 1.24e-31
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 568912824  1742 EFIRVWAEYDPAACGRISYNDMFEMLKHMSPPLGLGKKCPARVAYKRLVRMNMP 1795
Cdd:pfam16905    1 EFVRVWAEYDPAATGRISYQDMYELLRRISPPLGFGKKCPARVAYKRLVRMNMP 54
PHA03307 super family cl33723
transcriptional regulator ICP4; Provisional
1958-2325 5.65e-12

transcriptional regulator ICP4; Provisional


The actual alignment was detected with superfamily member PHA03307:

Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 71.74  E-value: 5.65e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912824 1958 TQDALYEARAPLERGHSAEIPVGQSGTLAVdVQMQNMTLRGPDGePQPGLesqGRAASMPRLAAETQPAPNASPMKRSIS 2037
Cdd:PHA03307   68 PTGPPPGPGTEAPANESRSTPTWSLSTLAP-ASPAREGSPTPPG-PSSPD---PPPPTPPPASPPPSPAPDLSEMLRPVG 142
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912824 2038 TLAPRPHGTQLCSTVLDRPPPS-QASHHHHHRCHRRRDKKQRSLEKGPS---LSVDPEGAPSTAAGPGLP--HGEGSTAC 2111
Cdd:PHA03307  143 SPGPPPAASPPAAGASPAAVASdAASSRQAALPLSSPEETARAPSSPPAeppPSTPPAAASPRPPRRSSPisASASSPAP 222
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912824 2112 RRDRKQERGRSQERRqpSSSSSEKQRfysCDRFGSREPPQLMPSLSSHPTSPTAALEPAPHPQGSGSV-NGSPLMSTSGA 2190
Cdd:PHA03307  223 APGRSAADDAGASSS--DSSSSESSG---CGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPAsSSSSPRERSPS 297
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912824 2191 STPGRGGRRQLPQTPLT------PRPSITYKTANSSPVhfAEGQSGLPAFSPGRlSRGLSEHNALLQKEPLSQPLAPGSR 2264
Cdd:PHA03307  298 PSPSSPGSGPAPSSPRAssssssSRESSSSSTSSSSES--SRGAAVSPGPSPSR-SPSPSRPPPPADPSSPRKRPRPSRA 374
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568912824 2265 IGSDPYLGQRLDSEASAHTLPEDTLTFEEAVATNSGRSSRTSYVSSLTSqSHPLRRVPNGY 2325
Cdd:PHA03307  375 PSSPAASAGRPTRRRARAAVAGRARRRDATGRFPAGRPRPSPLDAGAAS-GAFYARYPLLT 434
Granin super family cl27033
Granin (chromogranin or secretogranin);
935-1040 3.49e-03

Granin (chromogranin or secretogranin);


The actual alignment was detected with superfamily member pfam01271:

Pssm-ID: 279595 [Multi-domain]  Cd Length: 584  Bit Score: 42.71  E-value: 3.49e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912824   935 GSPEEATEREP---RRHRAHRHAQDSSKEGTAPVlvpkGERRARHRGPRtgPREAENNEEPTRRHRARHKVPPT--LQPP 1009
Cdd:pfam01271  264 GLEEEASEEEEeygEESRGLSAVQTYLLRLVNAR----GRGRSEKRAER--ERSEESEEEELKRASPYEELEITanLQIP 337
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 568912824  1010 ERE-------AAEKESNAVEGDK--ETRNHQPKEPHCDLE 1040
Cdd:pfam01271  338 PSEeermlkkAGRSPRGRVDEAGalEALEALEEKRKLDLD 377
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1484-1733 4.20e-74

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 247.18  E-value: 4.20e-74
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912824  1484 SPPFEYFIMAMIALNTVVLMMKFYDAPYE-YELMLKCLNIVFTSMFSMECILKIIAFGV-LNYFRDAWNVFDFVTVLGSI 1561
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912824  1562 TDILVTEIaetNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIALD 1641
Cdd:pfam00520   81 ISLVLSSV---GSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912824  1642 DDTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLGnracdphanasECGSDFAYFYFVSFIFLCSFLMLNLFVAVI 1721
Cdd:pfam00520  158 WENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTID-----------GKGEFWAYIYFVSFIILGGFLLLNLFIAVI 226
                          250
                   ....*....|..
gi 568912824  1722 MDNFEYLTRDSS 1733
Cdd:pfam00520  227 IDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
94-367 2.78e-66

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 224.84  E-value: 2.78e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912824    94 WPPFEYMILATIIANCIVLALEQHLPDgdKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVFHkgsYLRNGWNVMDFVV 173
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQP--EEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVV 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912824   174 VLTGIL----ATAGTDFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKF 249
Cdd:pfam00520   76 VLPSLIslvlSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912824   250 HKacfpnstdtepvgdfpcgkdpparqcdgdtecreyWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGN 329
Cdd:pfam00520  156 KT-----------------------------------WENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGE 200
                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 568912824   330 TWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVE 367
Cdd:pfam00520  201 FWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
482-721 9.66e-56

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 194.41  E-value: 9.66e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912824   482 AQSFYWVVLCVVALNTLCVAMVHYNQPQ-RLTTALYFAEFVFLGLFLTEMSLKMYGLGP-RSYFRSSFNCFDFGVIVGSI 559
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEePLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912824   560 FEVVWAAIKPGtsFGISVLRALRLLRIFKVTKYWNSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQ 639
Cdd:pfam00520   81 ISLVLSSVGSL--SGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTW 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912824   640 DE--TPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGgvskGMFSSFYFIVLTLFGNYTLLNVFLAIAVDNLANAQ 717
Cdd:pfam00520  159 ENpdNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG----EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELT 234

                   ....
gi 568912824   718 ELTK 721
Cdd:pfam00520  235 ERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1160-1394 1.15e-54

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 191.33  E-value: 1.15e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912824  1160 RYFEMVILVVIALSSIALAAEDPVRTDSFRNNALKYMDYIFTGVFTFEMVIKMIDLGLLLHpgaYFRDLWNILDFIVVSG 1239
Cdd:pfam00520    2 RYFELFILLLILLNTIFLALETYFQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVVVLP 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912824  1240 ALVAFAFSSFMGGSkgkdinTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFK 1319
Cdd:pfam00520   79 SLISLVLSSVGSLS------GLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFG 152
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568912824  1320 GKFfyctdeskelerdcrgqyldyeKEEVEAQPRqwkkyDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATYE 1394
Cdd:pfam00520  153 GKL----------------------KTWENPDNG-----RTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGE 200
Ca_chan_IQ pfam08763
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
1806-1883 1.89e-41

Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).


Pssm-ID: 462591  Cd Length: 77  Bit Score: 147.36  E-value: 1.89e-41
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568912824  1806 TSTLMALIRTALEIKLAPAGtKQHQCDAELRKEISSVWANLPQKTLDLLVPPHKPDEMTVGKVYAALMIFDFYKQNKT 1883
Cdd:pfam08763    1 TATLFALIRTSLKIKLAPAG-EMDQADAELRKIIKKIWPRLSQKTLDLLVPPPSDDEMTVGKIYAALLIQDYYRQNKA 77
GPHH pfam16905
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
1742-1795 1.24e-31

Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.


Pssm-ID: 465306  Cd Length: 54  Bit Score: 118.52  E-value: 1.24e-31
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 568912824  1742 EFIRVWAEYDPAACGRISYNDMFEMLKHMSPPLGLGKKCPARVAYKRLVRMNMP 1795
Cdd:pfam16905    1 EFVRVWAEYDPAATGRISYQDMYELLRRISPPLGFGKKCPARVAYKRLVRMNMP 54
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
1958-2325 5.65e-12

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 71.74  E-value: 5.65e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912824 1958 TQDALYEARAPLERGHSAEIPVGQSGTLAVdVQMQNMTLRGPDGePQPGLesqGRAASMPRLAAETQPAPNASPMKRSIS 2037
Cdd:PHA03307   68 PTGPPPGPGTEAPANESRSTPTWSLSTLAP-ASPAREGSPTPPG-PSSPD---PPPPTPPPASPPPSPAPDLSEMLRPVG 142
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912824 2038 TLAPRPHGTQLCSTVLDRPPPS-QASHHHHHRCHRRRDKKQRSLEKGPS---LSVDPEGAPSTAAGPGLP--HGEGSTAC 2111
Cdd:PHA03307  143 SPGPPPAASPPAAGASPAAVASdAASSRQAALPLSSPEETARAPSSPPAeppPSTPPAAASPRPPRRSSPisASASSPAP 222
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912824 2112 RRDRKQERGRSQERRqpSSSSSEKQRfysCDRFGSREPPQLMPSLSSHPTSPTAALEPAPHPQGSGSV-NGSPLMSTSGA 2190
Cdd:PHA03307  223 APGRSAADDAGASSS--DSSSSESSG---CGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPAsSSSSPRERSPS 297
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912824 2191 STPGRGGRRQLPQTPLT------PRPSITYKTANSSPVhfAEGQSGLPAFSPGRlSRGLSEHNALLQKEPLSQPLAPGSR 2264
Cdd:PHA03307  298 PSPSSPGSGPAPSSPRAssssssSRESSSSSTSSSSES--SRGAAVSPGPSPSR-SPSPSRPPPPADPSSPRKRPRPSRA 374
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568912824 2265 IGSDPYLGQRLDSEASAHTLPEDTLTFEEAVATNSGRSSRTSYVSSLTSqSHPLRRVPNGY 2325
Cdd:PHA03307  375 PSSPAASAGRPTRRRARAAVAGRARRRDATGRFPAGRPRPSPLDAGAAS-GAFYARYPLLT 434
Ca_chan_IQ smart01062
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
1861-1891 1.69e-10

Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).


Pssm-ID: 198130  Cd Length: 31  Bit Score: 57.62  E-value: 1.69e-10
                            10        20        30
                    ....*....|....*....|....*....|.
gi 568912824   1861 DEMTVGKVYAALMIFDFYKQNKTTRDQTHQA 1891
Cdd:smart01062    1 DELTVGKIYAAMLIQDYFRQFKSRKEQELLG 31
Hamartin pfam04388
Hamartin protein; This family includes the hamartin protein which is thought to function as a ...
2074-2342 1.10e-04

Hamartin protein; This family includes the hamartin protein which is thought to function as a tumour suppressor. The hamartin protein interacts with the tuberin protein pfam03542. Tuberous sclerosis complex (TSC) is an autosomal dominant disorder and is characterized by the presence of hamartomas in many organs, such as brain, skin, heart, lung, and kidney. It is caused by mutation either TSC1 or TSC2 tumour suppressor gene. TSC1 encodes a protein, hamartin, containing two coiled-coil regions, which have been shown to mediate binding to tuberin. The TSC2 gene codes for tuberin pfam03542. These two proteins function within the same pathway(s) regulating cell cycle, cell growth, adhesion, and vesicular trafficking.


Pssm-ID: 461287 [Multi-domain]  Cd Length: 730  Bit Score: 47.74  E-value: 1.10e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912824  2074 DKKQRSLEKG-PSLSVDPEGAPSTAAGPGlpHGEGSTACRrDRKQERGRSQERRQPSSSSSEkqrfySCDRFGSREP--- 2149
Cdd:pfam04388  259 DPKEASCEEGySSSAADPTASPYTDQQSS--YGSSTSTPS-STPRLQLSSSSGTSPPYLSPP-----SIRLKTDSFPlws 330
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912824  2150 PQLMPSLSSHPTSPTaaLEPAPHPQGSGSvngSPLMSTSGASTPGRGGRRQLPQTPLT-PRPSITYKTANSSPVHFAEGQ 2228
Cdd:pfam04388  331 PSSVCGMTTPPTSPG--MVPTTPSELSPS---SSHLSSRGSSPPEAAGEATPETTPAKdSPYLKQPPPLSDSHVHRALPA 405
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912824  2229 SGLPAfSPGRLSRGLSEHNALLQKEplsQPLAPGSRIGSDPyLGQRldSEASAHTLP----EDTLTFEEAVATNSGRSSR 2304
Cdd:pfam04388  406 SSQPS-SPPRKDGRSQSSFPPLSKQ---APTNPNSRGLLEP-PGDK--SSVTLSELPdfikDLALSSEDSVEGAEEEAAI 478
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....
gi 568912824  2305 TSYVSSLTsQSHPLRRVPNG------YHCTLGLSTGVRARHSYH 2342
Cdd:pfam04388  479 SQELSEIT-TEKNETDCSRGgldmpfSRTMESLAGSQRSRNRIA 521
Granin pfam01271
Granin (chromogranin or secretogranin);
935-1040 3.49e-03

Granin (chromogranin or secretogranin);


Pssm-ID: 279595 [Multi-domain]  Cd Length: 584  Bit Score: 42.71  E-value: 3.49e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912824   935 GSPEEATEREP---RRHRAHRHAQDSSKEGTAPVlvpkGERRARHRGPRtgPREAENNEEPTRRHRARHKVPPT--LQPP 1009
Cdd:pfam01271  264 GLEEEASEEEEeygEESRGLSAVQTYLLRLVNAR----GRGRSEKRAER--ERSEESEEEELKRASPYEELEITanLQIP 337
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 568912824  1010 ERE-------AAEKESNAVEGDK--ETRNHQPKEPHCDLE 1040
Cdd:pfam01271  338 PSEeermlkkAGRSPRGRVDEAGalEALEALEEKRKLDLD 377
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1484-1733 4.20e-74

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 247.18  E-value: 4.20e-74
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912824  1484 SPPFEYFIMAMIALNTVVLMMKFYDAPYE-YELMLKCLNIVFTSMFSMECILKIIAFGV-LNYFRDAWNVFDFVTVLGSI 1561
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912824  1562 TDILVTEIaetNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIALD 1641
Cdd:pfam00520   81 ISLVLSSV---GSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912824  1642 DDTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLGnracdphanasECGSDFAYFYFVSFIFLCSFLMLNLFVAVI 1721
Cdd:pfam00520  158 WENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTID-----------GKGEFWAYIYFVSFIILGGFLLLNLFIAVI 226
                          250
                   ....*....|..
gi 568912824  1722 MDNFEYLTRDSS 1733
Cdd:pfam00520  227 IDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
94-367 2.78e-66

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 224.84  E-value: 2.78e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912824    94 WPPFEYMILATIIANCIVLALEQHLPDgdKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVFHkgsYLRNGWNVMDFVV 173
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQP--EEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVV 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912824   174 VLTGIL----ATAGTDFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKF 249
Cdd:pfam00520   76 VLPSLIslvlSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912824   250 HKacfpnstdtepvgdfpcgkdpparqcdgdtecreyWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGN 329
Cdd:pfam00520  156 KT-----------------------------------WENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGE 200
                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 568912824   330 TWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVE 367
Cdd:pfam00520  201 FWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
482-721 9.66e-56

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 194.41  E-value: 9.66e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912824   482 AQSFYWVVLCVVALNTLCVAMVHYNQPQ-RLTTALYFAEFVFLGLFLTEMSLKMYGLGP-RSYFRSSFNCFDFGVIVGSI 559
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEePLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912824   560 FEVVWAAIKPGtsFGISVLRALRLLRIFKVTKYWNSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQ 639
Cdd:pfam00520   81 ISLVLSSVGSL--SGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTW 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912824   640 DE--TPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGgvskGMFSSFYFIVLTLFGNYTLLNVFLAIAVDNLANAQ 717
Cdd:pfam00520  159 ENpdNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG----EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELT 234

                   ....
gi 568912824   718 ELTK 721
Cdd:pfam00520  235 ERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1160-1394 1.15e-54

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 191.33  E-value: 1.15e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912824  1160 RYFEMVILVVIALSSIALAAEDPVRTDSFRNNALKYMDYIFTGVFTFEMVIKMIDLGLLLHpgaYFRDLWNILDFIVVSG 1239
Cdd:pfam00520    2 RYFELFILLLILLNTIFLALETYFQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVVVLP 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912824  1240 ALVAFAFSSFMGGSkgkdinTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFK 1319
Cdd:pfam00520   79 SLISLVLSSVGSLS------GLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFG 152
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568912824  1320 GKFfyctdeskelerdcrgqyldyeKEEVEAQPRqwkkyDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATYE 1394
Cdd:pfam00520  153 GKL----------------------KTWENPDNG-----RTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGE 200
Ca_chan_IQ pfam08763
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
1806-1883 1.89e-41

Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).


Pssm-ID: 462591  Cd Length: 77  Bit Score: 147.36  E-value: 1.89e-41
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568912824  1806 TSTLMALIRTALEIKLAPAGtKQHQCDAELRKEISSVWANLPQKTLDLLVPPHKPDEMTVGKVYAALMIFDFYKQNKT 1883
Cdd:pfam08763    1 TATLFALIRTSLKIKLAPAG-EMDQADAELRKIIKKIWPRLSQKTLDLLVPPPSDDEMTVGKIYAALLIQDYYRQNKA 77
GPHH pfam16905
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
1742-1795 1.24e-31

Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.


Pssm-ID: 465306  Cd Length: 54  Bit Score: 118.52  E-value: 1.24e-31
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 568912824  1742 EFIRVWAEYDPAACGRISYNDMFEMLKHMSPPLGLGKKCPARVAYKRLVRMNMP 1795
Cdd:pfam16905    1 EFVRVWAEYDPAATGRISYQDMYELLRRISPPLGFGKKCPARVAYKRLVRMNMP 54
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
1958-2325 5.65e-12

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 71.74  E-value: 5.65e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912824 1958 TQDALYEARAPLERGHSAEIPVGQSGTLAVdVQMQNMTLRGPDGePQPGLesqGRAASMPRLAAETQPAPNASPMKRSIS 2037
Cdd:PHA03307   68 PTGPPPGPGTEAPANESRSTPTWSLSTLAP-ASPAREGSPTPPG-PSSPD---PPPPTPPPASPPPSPAPDLSEMLRPVG 142
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912824 2038 TLAPRPHGTQLCSTVLDRPPPS-QASHHHHHRCHRRRDKKQRSLEKGPS---LSVDPEGAPSTAAGPGLP--HGEGSTAC 2111
Cdd:PHA03307  143 SPGPPPAASPPAAGASPAAVASdAASSRQAALPLSSPEETARAPSSPPAeppPSTPPAAASPRPPRRSSPisASASSPAP 222
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912824 2112 RRDRKQERGRSQERRqpSSSSSEKQRfysCDRFGSREPPQLMPSLSSHPTSPTAALEPAPHPQGSGSV-NGSPLMSTSGA 2190
Cdd:PHA03307  223 APGRSAADDAGASSS--DSSSSESSG---CGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPAsSSSSPRERSPS 297
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912824 2191 STPGRGGRRQLPQTPLT------PRPSITYKTANSSPVhfAEGQSGLPAFSPGRlSRGLSEHNALLQKEPLSQPLAPGSR 2264
Cdd:PHA03307  298 PSPSSPGSGPAPSSPRAssssssSRESSSSSTSSSSES--SRGAAVSPGPSPSR-SPSPSRPPPPADPSSPRKRPRPSRA 374
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568912824 2265 IGSDPYLGQRLDSEASAHTLPEDTLTFEEAVATNSGRSSRTSYVSSLTSqSHPLRRVPNGY 2325
Cdd:PHA03307  375 PSSPAASAGRPTRRRARAAVAGRARRRDATGRFPAGRPRPSPLDAGAAS-GAFYARYPLLT 434
PKD_channel pfam08016
Polycystin cation channel; This family contains the cation channel region from group II of ...
1507-1726 1.59e-11

Polycystin cation channel; This family contains the cation channel region from group II of Transient receptor potential (TRP) channels, the TRPP subfamily, including PKD1, PKD2, PKD2L and mucolipin proteins.


Pssm-ID: 462341 [Multi-domain]  Cd Length: 225  Bit Score: 66.15  E-value: 1.59e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912824  1507 YDAPYEYELMLkCLNI--VFTSMFSMECILKIIAFGvLNYFRDAWNVFDFVTVLGSIT--------DILVTE-----IAE 1571
Cdd:pfam08016    2 YVTNRSLFILL-CEIVfvVFFLYFVVEEILKIRKHR-PSYLRSVWNLLDLAIVILSVVlivlniyrDFLADRliksvEAS 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912824  1572 TNNFIN--------------LSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGN 1637
Cdd:pfam08016   80 PVTFIDfdrvaqldnlyriiLAFLVFLTWLKLFKVLRFNKTMSLFTKTLSRAWKDLAGFALMFVIFFFAYAQFGYLLFGT 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912824  1638 ialdddtsinRHNNFRTFLQALMLLFRsatgeawheIMLSCLGNRACDphanasECGSDFAYFYFVSFIFLCSFLMLNLF 1717
Cdd:pfam08016  160 ----------QAPNFSNFVKSILTLFR---------TILGDFGYNEIF------SGNRVLGPLLFLTFVFLVIFILLNLF 214

                   ....*....
gi 568912824  1718 VAVIMDNFE 1726
Cdd:pfam08016  215 LAIINDSYV 223
Ca_chan_IQ smart01062
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
1861-1891 1.69e-10

Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).


Pssm-ID: 198130  Cd Length: 31  Bit Score: 57.62  E-value: 1.69e-10
                            10        20        30
                    ....*....|....*....|....*....|.
gi 568912824   1861 DEMTVGKVYAALMIFDFYKQNKTTRDQTHQA 1891
Cdd:smart01062    1 DELTVGKIYAAMLIQDYFRQFKSRKEQELLG 31
PHA03247 PHA03247
large tegument protein UL36; Provisional
2001-2322 2.75e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 59.95  E-value: 2.75e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912824 2001 GEPQPGLESQGRAASMPRLAAETQPAPNasPMKRSISTLAPRP----HGTQLCSTVLDR-PPPSQASHHHHHRCHRRRDK 2075
Cdd:PHA03247 2549 GDPPPPLPPAAPPAAPDRSVPPPRPAPR--PSEPAVTSRARRPdappQSARPRAPVDDRgDPRGPAPPSPLPPDTHAPDP 2626
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912824 2076 KQRSlekgPSLSVDPEGAPSTAAGPGLPHGEGSTACRRDRKQERGRSQERRQPSSSSSEKQR-------FYSCDRFGSRE 2148
Cdd:PHA03247 2627 PPPS----PSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRrraarptVGSLTSLADPP 2702
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912824 2149 PPQLMPSLSSHPTSPTAALEPAPHPQGSGS----VNGSPLMSTSGASTPG---RGGRRQLPQTPLTPRPSITYKTANSSP 2221
Cdd:PHA03247 2703 PPPPTPEPAPHALVSATPLPPGPAAARQASpalpAAPAPPAVPAGPATPGgpaRPARPPTTAGPPAPAPPAAPAAGPPRR 2782
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912824 2222 VHFAEGQSGLPAFSPGRLSRGLSEHNALLQKEPLSQPLAPGSRIGSDPYLGQRLDSEASAHTLPEDTLTFEEAVATN--- 2298
Cdd:PHA03247 2783 LTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGgdv 2862
                         330       340
                  ....*....|....*....|....*
gi 568912824 2299 SGRSSRTSYVSSLTSQSHP-LRRVP 2322
Cdd:PHA03247 2863 RRRPPSRSPAAKPAAPARPpVRRLA 2887
PHA03247 PHA03247
large tegument protein UL36; Provisional
1997-2291 4.87e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.17  E-value: 4.87e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912824 1997 RGPDGEPQPGLESQGRAASMPRL-------------AAETQPAPNASPMKRSISTLAPRPHGTQLCSTVldRPPPSQASH 2063
Cdd:PHA03247 2773 AAPAAGPPRRLTRPAVASLSESReslpspwdpadppAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPP--PPGPPPPSL 2850
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912824 2064 HHHHRCHRRRDKKQRslekGPSLSvdPEGAPSTAAGPGLPHGEGSTACRRDRKQERGRSQERRQPSSSSSEKQRFYSCDR 2143
Cdd:PHA03247 2851 PLGGSVAPGGDVRRR----PPSRS--PAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPP 2924
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912824 2144 FGSREPPQLMPslsshPTSPTAALEPAPHPQGSGSVNGSPLMSTSGASTPGRGG--RRQLPQtpltPRPSITYKTANSSP 2221
Cdd:PHA03247 2925 PPPQPQPPPPP-----PPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAvpRFRVPQ----PAPSREAPASSTPP 2995
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912824 2222 VHfaegQSGLPAFSPGRLSRGLSEHNAllqKEPLS--QPLAP---------GSRIGSDPylgQRLDSEASAHTLPEDTLT 2290
Cdd:PHA03247 2996 LT----GHSLSRVSSWASSLALHEETD---PPPVSlkQTLWPpddtedsdaDSLFDSDS---ERSDLEALDPLPPEPHDP 3065

                  .
gi 568912824 2291 F 2291
Cdd:PHA03247 3066 F 3066
Hamartin pfam04388
Hamartin protein; This family includes the hamartin protein which is thought to function as a ...
2074-2342 1.10e-04

Hamartin protein; This family includes the hamartin protein which is thought to function as a tumour suppressor. The hamartin protein interacts with the tuberin protein pfam03542. Tuberous sclerosis complex (TSC) is an autosomal dominant disorder and is characterized by the presence of hamartomas in many organs, such as brain, skin, heart, lung, and kidney. It is caused by mutation either TSC1 or TSC2 tumour suppressor gene. TSC1 encodes a protein, hamartin, containing two coiled-coil regions, which have been shown to mediate binding to tuberin. The TSC2 gene codes for tuberin pfam03542. These two proteins function within the same pathway(s) regulating cell cycle, cell growth, adhesion, and vesicular trafficking.


Pssm-ID: 461287 [Multi-domain]  Cd Length: 730  Bit Score: 47.74  E-value: 1.10e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912824  2074 DKKQRSLEKG-PSLSVDPEGAPSTAAGPGlpHGEGSTACRrDRKQERGRSQERRQPSSSSSEkqrfySCDRFGSREP--- 2149
Cdd:pfam04388  259 DPKEASCEEGySSSAADPTASPYTDQQSS--YGSSTSTPS-STPRLQLSSSSGTSPPYLSPP-----SIRLKTDSFPlws 330
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912824  2150 PQLMPSLSSHPTSPTaaLEPAPHPQGSGSvngSPLMSTSGASTPGRGGRRQLPQTPLT-PRPSITYKTANSSPVHFAEGQ 2228
Cdd:pfam04388  331 PSSVCGMTTPPTSPG--MVPTTPSELSPS---SSHLSSRGSSPPEAAGEATPETTPAKdSPYLKQPPPLSDSHVHRALPA 405
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912824  2229 SGLPAfSPGRLSRGLSEHNALLQKEplsQPLAPGSRIGSDPyLGQRldSEASAHTLP----EDTLTFEEAVATNSGRSSR 2304
Cdd:pfam04388  406 SSQPS-SPPRKDGRSQSSFPPLSKQ---APTNPNSRGLLEP-PGDK--SSVTLSELPdfikDLALSSEDSVEGAEEEAAI 478
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....
gi 568912824  2305 TSYVSSLTsQSHPLRRVPNG------YHCTLGLSTGVRARHSYH 2342
Cdd:pfam04388  479 SQELSEIT-TEKNETDCSRGgldmpfSRTMESLAGSQRSRNRIA 521
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
2025-2246 1.88e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 47.09  E-value: 1.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912824 2025 PAPNASPMKRSISTLAPRPHGTQLCSTVLDRPPPSQASHHHHHRCHRRRDKKQRSLEKGPSLSVDPEGAPStAAGPGLPh 2104
Cdd:PHA03307  761 PSLVPAKLAEALALLEPAEPQRGAGSSPPVRAEAAFRRPGRLRRSGPAADAASRTASKRKSRSHTPDGGSE-SSGPARP- 838
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912824 2105 gEGSTACRRDRKQERGRSQERRQPSSSSSEKQRfysCDRFGSREPPQLMPSLSSHPTSPTAALEPAP----HPQGSGSVN 2180
Cdd:PHA03307  839 -PGAAARPPPARSSESSKSKPAAAGGRARGKNG---RRRPRPPEPRARPGAAAPPKAAAAAPPAGAPaprpRPAPRVKLG 914
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568912824 2181 GSPLmstsGASTPGRGGRRQLPQTPLTPRPSityktansspvhfaegQSGLPAFSPGRLSRGLSEH 2246
Cdd:PHA03307  915 PMPP----GGPDPRGGFRRVPPGDLHTPAPS----------------AAALAAYCPPEVVAELVDH 960
CLEC16A_C pfam19439
CLEC16A C-terminal; This is the C-terminal domain of C-type lectin domain family 16, member A ...
2084-2302 3.48e-04

CLEC16A C-terminal; This is the C-terminal domain of C-type lectin domain family 16, member A (CLEC16A, the Drosophila orthologue Ema and GOP-1 in C. elegans), an evolutionarily conserved endosomal membrane protein required for trafficking of fluid-phase and receptor-mediated endocytic cargos. It is required for mitophagy, autophagy and endosome maturation. This protein has been identified as a susceptibility gene for autoimmune diseases like type 1 diabetes, multiple sclerosis and adrenal dysfunction. This domain is also present in GFS9/TT9 (TRANSPARENT TESTA 9) a protein from Arabidopsis required for vacuolar development through membrane fusion at vacuoles and for membrane trafficking machinery and accumulation of flavonoids in the seed coat.


Pssm-ID: 466083  Cd Length: 762  Bit Score: 46.03  E-value: 3.48e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912824  2084 PSLSVDPEGAPSTAAGPGLPHgegstacrrdrkqeRGRSQERRQPSSSSSEKQRFYSCDRFGSREPPQLMPSlssHPTSP 2163
Cdd:pfam19439  583 PSTEVLGFGQTSSASSQHLPF--------------RFYEQSRRGPSDPTVQRSVFASVDKVPGFAVAQCINQ---HSPSP 645
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912824  2164 TAALEPAPHPQGSGSVNGSPLMSTSGASTPGRGGRrqlPQTPLTPRPSITYKTANSSPVHFAEGQSGLPAfspgrlsrgl 2243
Cdd:pfam19439  646 LSSPSPPSSSSGSGSTGRCDSVTASSTSTPSPSDD---GSTPEQPQLPDELAFLDSTPAVSKPGKSSASS---------- 712
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 568912824  2244 sehnallQKEPLSqpLAPGSRIGSDPYLGqrLDSEASAHTLPEDTLTFEEAVATNSGRS 2302
Cdd:pfam19439  713 -------ETEPAA--LAPSLTPAPQPTIS--LLSDDSTDALSVESLTLLPPADSPHLRS 760
Granin pfam01271
Granin (chromogranin or secretogranin);
935-1040 3.49e-03

Granin (chromogranin or secretogranin);


Pssm-ID: 279595 [Multi-domain]  Cd Length: 584  Bit Score: 42.71  E-value: 3.49e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912824   935 GSPEEATEREP---RRHRAHRHAQDSSKEGTAPVlvpkGERRARHRGPRtgPREAENNEEPTRRHRARHKVPPT--LQPP 1009
Cdd:pfam01271  264 GLEEEASEEEEeygEESRGLSAVQTYLLRLVNAR----GRGRSEKRAER--ERSEESEEEELKRASPYEELEITanLQIP 337
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 568912824  1010 ERE-------AAEKESNAVEGDK--ETRNHQPKEPHCDLE 1040
Cdd:pfam01271  338 PSEeermlkkAGRSPRGRVDEAGalEALEALEEKRKLDLD 377
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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