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Conserved domains on  [gi|568911971|ref|XP_006497300|]
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membrane cofactor protein isoform X3 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA02927 super family cl33700
secreted complement-binding protein; Provisional
 11-243 5.62e-42

secreted complement-binding protein; Provisional


The actual alignment was detected with superfamily member PHA02927:

Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 146.34  E-value: 5.62e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568911971  11 YAVGEKIEYKCKKGYLYLSPYLMIATCEPNhTWVPISDagCIKVQCTMLQDPSFGKVYYidGSFSWGARAKFTCMEGYYV 90
Cdd:PHA02927  44 YNIGDTIEYLCLPGYRKQKMGPIYAKCTGT-GWTLFNQ--CIKRRCPSPRDIDNGQLDI--GGVDFGSSITYSCNSGYQL 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568911971  91 VGMSVLHCVLKGDDEAYWNGYPPHCEKIYCLPPPKIKNGTHTLTDiNVFKYHEAVSYSCDptpgpDKFSLVGTSMIFCAG 170
Cdd:PHA02927 119 IGESKSYCELGSTGSMVWNPEAPICESVKCQSPPSISNGRHNGYE-DFYTDGSVVTYSCN-----SGYSLIGNSGVLCSG 192

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568911971 171 hNTWSNsPPECKVVKCPNPVLQNGRLISGAGEIFSYQSTVMFECLQGFYMEGSSMVICSANNSWEPSIPKCLK 243
Cdd:PHA02927 193 -GEWSD-PPTCQIVKCPHPTISNGYLSSGFKRSYSYNDNVDFKCKYGYKLSGSSSSTCSPGNTWQPELPKCVR 263
 
Name Accession Description Interval E-value
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 11-243 5.62e-42

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 146.34  E-value: 5.62e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568911971  11 YAVGEKIEYKCKKGYLYLSPYLMIATCEPNhTWVPISDagCIKVQCTMLQDPSFGKVYYidGSFSWGARAKFTCMEGYYV 90
Cdd:PHA02927  44 YNIGDTIEYLCLPGYRKQKMGPIYAKCTGT-GWTLFNQ--CIKRRCPSPRDIDNGQLDI--GGVDFGSSITYSCNSGYQL 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568911971  91 VGMSVLHCVLKGDDEAYWNGYPPHCEKIYCLPPPKIKNGTHTLTDiNVFKYHEAVSYSCDptpgpDKFSLVGTSMIFCAG 170
Cdd:PHA02927 119 IGESKSYCELGSTGSMVWNPEAPICESVKCQSPPSISNGRHNGYE-DFYTDGSVVTYSCN-----SGYSLIGNSGVLCSG 192

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568911971 171 hNTWSNsPPECKVVKCPNPVLQNGRLISGAGEIFSYQSTVMFECLQGFYMEGSSMVICSANNSWEPSIPKCLK 243
Cdd:PHA02927 193 -GEWSD-PPTCQIVKCPHPTISNGYLSSGFKRSYSYNDNVDFKCKYGYKLSGSSSSTCSPGNTWQPELPKCVR 263
Sushi pfam00084
Sushi repeat (SCR repeat);
56-115 9.26e-13

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 62.13  E-value: 9.26e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568911971   56 CTMLQDPSFGKVYYIDGSFSWGARAKFTCMEGYYVVGMSVLHCVLKGddeaYWNGYPPHC 115
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPTITCQEDG----TWSPPFPEC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 186-241 1.85e-10

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 55.55  E-value: 1.85e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 568911971 186 CPNP-VLQNGRLISGAGEiFSYQSTVMFECLQGFYMEGSSMVICSANNSWEPSIPKC 241
Cdd:cd00033    1 CPPPpVPENGTVTGSKGS-YSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 186-241 2.17e-09

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 52.53  E-value: 2.17e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 568911971   186 CPNP-VLQNGRlISGAGEIFSYQSTVMFECLQGFYMEGSSMVICSANNSWEPSIPKC 241
Cdd:smart00032   1 CPPPpDIENGT-VTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56
 
Name Accession Description Interval E-value
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 11-243 5.62e-42

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 146.34  E-value: 5.62e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568911971  11 YAVGEKIEYKCKKGYLYLSPYLMIATCEPNhTWVPISDagCIKVQCTMLQDPSFGKVYYidGSFSWGARAKFTCMEGYYV 90
Cdd:PHA02927  44 YNIGDTIEYLCLPGYRKQKMGPIYAKCTGT-GWTLFNQ--CIKRRCPSPRDIDNGQLDI--GGVDFGSSITYSCNSGYQL 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568911971  91 VGMSVLHCVLKGDDEAYWNGYPPHCEKIYCLPPPKIKNGTHTLTDiNVFKYHEAVSYSCDptpgpDKFSLVGTSMIFCAG 170
Cdd:PHA02927 119 IGESKSYCELGSTGSMVWNPEAPICESVKCQSPPSISNGRHNGYE-DFYTDGSVVTYSCN-----SGYSLIGNSGVLCSG 192

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568911971 171 hNTWSNsPPECKVVKCPNPVLQNGRLISGAGEIFSYQSTVMFECLQGFYMEGSSMVICSANNSWEPSIPKCLK 243
Cdd:PHA02927 193 -GEWSD-PPTCQIVKCPHPTISNGYLSSGFKRSYSYNDNVDFKCKYGYKLSGSSSSTCSPGNTWQPELPKCVR 263
PHA02639 PHA02639
EEV host range protein; Provisional
 50-243 8.29e-23

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 95.89  E-value: 8.29e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568911971  50 GCIKVQCTMLQDPSFGKVYYIDGSFSWGARAKFTCMEGYYVVGMSVLHCVlKGDDEAYWNGYPPHCEKIYCLPPPKIKNG 129
Cdd:PHA02639  16 GVKSIYCDKPDDISNGFITELMEKYEIGKLIEYTCNTDYALIGDRFRTCI-KDKNNAIWSNKAPFCMLKECNDPPSIING 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568911971 130 ThTLTDINVFKYHEAVSYSCDPTPGPdKFSLVGTSMIFCAGHNTWSNSPPECKVVKCPNPVLQNGrLISG--AGEIFSYQ 207
Cdd:PHA02639  95 K-IYNKREMYKVGDEIYYVCNEHKGV-QYSLVGNEKITCIQDKSWKPDPPICKMINCRFPALQNG-YINGipSNKKFYYK 171

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 568911971 208 STVMFECLQGFYMEGSSMVICSANNSWEPSIPKCLK 243
Cdd:PHA02639 172 TRVGFSCKSGFDLVGEKYSTCNINATWFPSIPTCVR 207
PHA02817 PHA02817
EEV Host range protein; Provisional
 115-243 2.36e-18

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 82.30  E-value: 2.36e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568911971 115 CEKIYCLPPPKIKNGtHTLTDINVFKYHEAVSYSCDPTPGPDKFSLVGTSMIFCAGHNTWSNSPPECKVVKCPNPVLQNG 194
Cdd:PHA02817  19 CDLNKCCYPPSIKNG-YIYNKKTEYNIGSNVTFFCGNNTRGVRYTLVGEKNIICEKDGKWNKEFPVCKIIRCRFPALQNG 97

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 568911971 195 rLISG--AGEIFSYQSTVMFECLQGFYMEGSSMVICSANNSWEPSIPKCLK 243
Cdd:PHA02817  98 -FVNGipDSKKFYYESEVSFSCKPGFVLIGTKYSVCGINSSWIPKVPICSR 147
PHA02831 PHA02831
EEV host range protein; Provisional
 117-308 3.31e-15

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 74.26  E-value: 3.31e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568911971 117 KIYCLPPPKIKNGtHTLTDINVFKYHEAVSYSCDPTPgPDKFSLVGTSMIFCAgHNTWSNSPPECKVVKCPNPVLQNGRL 196
Cdd:PHA02831  75 KRNCKDPVTILNG-YIKNKKDQYSFGDSVTYACKVNK-LEKYSIVGNETVKCI-NKQWVPKYPVCKLIRCKYPALQNGFL 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568911971 197 ISGAGEiFSYQSTVMFECLQGFYMEGSSMVICSANNSWEPSIPKCLKGP-----RPTHPTKPPVYNYTGYPSpreGIFSQ 271
Cdd:PHA02831 152 NVFEKK-FYYGDIVNFKCKKGFILLGSSVSTCDINSIWYPGIPKCVKDKvhneiQPNYLFDDLDEDFNNSTT---NYNMQ 227

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 568911971 272 ELDAWIIALIVITSIVGVFILCLIVLRCFEHRKKTSI 308
Cdd:PHA02831 228 QNIITIIILLSIICFIFVLGLIALFLSCNKSTLKPSI 264
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 42-248 3.01e-14

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 71.61  E-value: 3.01e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568911971  42 TWVPISDAGCIKVQCTMLQDPSFGKV-----YYIDGSFSWGARAKFTCMEGYYVVGMSVLHCVLKGDDEAYWNgyppHCE 116
Cdd:PHA02927   7 TFLTLLGIGCVLSCCTIPSRPINMKFknsveTDANANYNIGDTIEYLCLPGYRKQKMGPIYAKCTGTGWTLFN----QCI 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568911971 117 KIYCLPPPKIKNGThtlTDINVFKYHEAVSYSCDptpgpDKFSLVGTSMIFC----AGHNTWSNSPPECKVVKCPNP-VL 191
Cdd:PHA02927  83 KRRCPSPRDIDNGQ---LDIGGVDFGSSITYSCN-----SGYQLIGESKSYCelgsTGSMVWNPEAPICESVKCQSPpSI 154

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 568911971 192 QNGRLiSGAGEIFSYQSTVMFECLQGFYMEGSSMVICSANNSWEPSIPKCLKGPRPT 248
Cdd:PHA02927 155 SNGRH-NGYEDFYTDGSVVTYSCNSGYSLIGNSGVLCSGGEWSDPPTCQIVKCPHPT 210
Sushi pfam00084
Sushi repeat (SCR repeat);
56-115 9.26e-13

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 62.13  E-value: 9.26e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568911971   56 CTMLQDPSFGKVYYIDGSFSWGARAKFTCMEGYYVVGMSVLHCVLKGddeaYWNGYPPHC 115
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPTITCQEDG----TWSPPFPEC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 186-241 1.85e-10

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 55.55  E-value: 1.85e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 568911971 186 CPNP-VLQNGRLISGAGEiFSYQSTVMFECLQGFYMEGSSMVICSANNSWEPSIPKC 241
Cdd:cd00033    1 CPPPpVPENGTVTGSKGS-YSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
186-241 2.81e-10

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 55.20  E-value: 2.81e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 568911971  186 CPNP-VLQNGRlISGAGEIFSYQSTVMFECLQGFYMEGSSMVICSANNSWEPSIPKC 241
Cdd:pfam00084   1 CPPPpDIPNGK-VSATKNEYNYGASVSYECDPGYRLVGSPTITCQEDGTWSPPFPEC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 186-241 2.17e-09

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 52.53  E-value: 2.17e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 568911971   186 CPNP-VLQNGRlISGAGEIFSYQSTVMFECLQGFYMEGSSMVICSANNSWEPSIPKC 241
Cdd:smart00032   1 CPPPpDIENGT-VTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 120-182 1.07e-08

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 50.92  E-value: 1.07e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568911971 120 CLPPPKIKNGTHTLTDiNVFKYHEAVSYSCDPtpgpdKFSLVGTSMIFCAGHNTWSNSPPECK 182
Cdd:cd00033    1 CPPPPVPENGTVTGSK-GSYSYGSTVTYSCNE-----GYTLVGSSTITCTENGGWSPPPPTCE 57
Sushi pfam00084
Sushi repeat (SCR repeat);
120-181 6.17e-08

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 48.65  E-value: 6.17e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568911971  120 CLPPPKIKNGTHTLTDiNVFKYHEAVSYSCDPTpgpdkFSLVGTSMIFCAGHNTWSNSPPEC 181
Cdd:pfam00084   1 CPPPPDIPNGKVSATK-NEYNYGASVSYECDPG-----YRLVGSPTITCQEDGTWSPPFPEC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 56-116 1.04e-07

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 47.84  E-value: 1.04e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568911971  56 CTMLQDPSFGKVYYIDGSFSWGARAKFTCMEGYYVVGMSVLHCVLKGDdeayWNGYPPHCE 116
Cdd:cd00033    1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTENGG----WSPPPPTCE 57
PHA02954 PHA02954
EEV membrane glycoprotein; Provisional
 139-299 2.77e-07

EEV membrane glycoprotein; Provisional


Pssm-ID: 165263 [Multi-domain]  Cd Length: 317  Bit Score: 51.24  E-value: 2.77e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568911971 139 FKYHEAVSYSCDPtpgpdKFSLVGTSMIFCAGhNTWsNSPPECKVvKCPNPVLQNGrLISGAgeIFSYQSTVMFECLQGF 218
Cdd:PHA02954 147 YSFGEHITINCDV-----GYEVIGASYISCTA-NSW-NVIPSCQQ-KCDIPSLSNG-LISGS--TFSIGGVIHLSCKSGF 215

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568911971 219 YMEGSSMVICsANNSWEPSIPKCLKGPRPTHPTKPPVYNYTGYPSPREGIFSQE-----LDAWIIALIVITSIVGV-FIL 292
Cdd:PHA02954 216 TLTGSPSSTC-IDGKWNPVLPICVRSNEEFDPVDDGPDDETDLSKLSKDVVQYEqeiesLEATYHIIIVALTIMGViFLI 294


                 ....*..
gi 568911971 293 CLIVLRC 299
Cdd:PHA02954 295 SVIVLVC 301
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 120-181 2.92e-07

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 46.75  E-value: 2.92e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568911971   120 CLPPPKIKNGTHTLTDiNVFKYHEAVSYSCDPtpgpdKFSLVGTSMIFCAGHNTWSNSPPEC 181
Cdd:smart00032   1 CPPPPDIENGTVTSSS-GTYSYGDTVTYSCDP-----GYTLIGSSTITCLENGTWSPPPPTC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 56-115 1.38e-06

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 44.82  E-value: 1.38e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568911971    56 CTMLQDPSFGKVYYIDGSFSWGARAKFTCMEGYYVVGMSVLHCVLKGDdeayWNGYPPHC 115
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLENGT----WSPPPPTC 56
PHA02817 PHA02817
EEV Host range protein; Provisional
 51-181 1.74e-05

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 45.32  E-value: 1.74e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568911971  51 CIKVQCTMLQDPSFGKVYYIDGSFSWGARAKFTCMEG-----YYVVGMSVLHCvlkgDDEAYWNGYPPHCEKIYClPPPK 125
Cdd:PHA02817  19 CDLNKCCYPPSIKNGYIYNKKTEYNIGSNVTFFCGNNtrgvrYTLVGEKNIIC----EKDGKWNKEFPVCKIIRC-RFPA 93

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 568911971 126 IKNG-THTLTDINVFKYHEAVSYSCDPtpgpdKFSLVGTSMIFCAGHNTWSNSPPEC 181
Cdd:PHA02817  94 LQNGfVNGIPDSKKFYYESEVSFSCKP-----GFVLIGTKYSVCGINSSWIPKVPIC 145
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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