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Conserved domains on  [gi|568911963|ref|XP_006497297|]
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membrane cofactor protein isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA02927 super family cl33700
secreted complement-binding protein; Provisional
 64-296 6.50e-42

secreted complement-binding protein; Provisional


The actual alignment was detected with superfamily member PHA02927:

Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 147.49  E-value: 6.50e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568911963  64 YAVGEKIEYKCKKGYLYLSPYLMIATCEPNhTWVPISDagCIKVQCTMLQDPSFGKVYYidGSFSWGARAKFTCMEGYYV 143
Cdd:PHA02927  44 YNIGDTIEYLCLPGYRKQKMGPIYAKCTGT-GWTLFNQ--CIKRRCPSPRDIDNGQLDI--GGVDFGSSITYSCNSGYQL 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568911963 144 VGMSVLHCVLKGDDEAYWNGYPPHCEKIYCLPPPKIKNGTHTLTDiNVFKYHEAVSYSCDptpgpDKFSLVGTSMIFCAG 223
Cdd:PHA02927 119 IGESKSYCELGSTGSMVWNPEAPICESVKCQSPPSISNGRHNGYE-DFYTDGSVVTYSCN-----SGYSLIGNSGVLCSG 192

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568911963 224 hNTWSNsPPECKVVKCPNPVLQNGRLISGAGEIFSYQSTVMFECLQGFYMEGSSMVICSANNSWEPSIPKCLK 296
Cdd:PHA02927 193 -GEWSD-PPTCQIVKCPHPTISNGYLSSGFKRSYSYNDNVDFKCKYGYKLSGSSSSTCSPGNTWQPELPKCVR 263
 
Name Accession Description Interval E-value
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 64-296 6.50e-42

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 147.49  E-value: 6.50e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568911963  64 YAVGEKIEYKCKKGYLYLSPYLMIATCEPNhTWVPISDagCIKVQCTMLQDPSFGKVYYidGSFSWGARAKFTCMEGYYV 143
Cdd:PHA02927  44 YNIGDTIEYLCLPGYRKQKMGPIYAKCTGT-GWTLFNQ--CIKRRCPSPRDIDNGQLDI--GGVDFGSSITYSCNSGYQL 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568911963 144 VGMSVLHCVLKGDDEAYWNGYPPHCEKIYCLPPPKIKNGTHTLTDiNVFKYHEAVSYSCDptpgpDKFSLVGTSMIFCAG 223
Cdd:PHA02927 119 IGESKSYCELGSTGSMVWNPEAPICESVKCQSPPSISNGRHNGYE-DFYTDGSVVTYSCN-----SGYSLIGNSGVLCSG 192

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568911963 224 hNTWSNsPPECKVVKCPNPVLQNGRLISGAGEIFSYQSTVMFECLQGFYMEGSSMVICSANNSWEPSIPKCLK 296
Cdd:PHA02927 193 -GEWSD-PPTCQIVKCPHPTISNGYLSSGFKRSYSYNDNVDFKCKYGYKLSGSSSSTCSPGNTWQPELPKCVR 263
Sushi pfam00084
Sushi repeat (SCR repeat);
109-168 9.14e-13

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 62.52  E-value: 9.14e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568911963  109 CTMLQDPSFGKVYYIDGSFSWGARAKFTCMEGYYVVGMSVLHCVLKGddeaYWNGYPPHC 168
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPTITCQEDG----TWSPPFPEC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 239-294 1.49e-10

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 56.32  E-value: 1.49e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 568911963 239 CPNP-VLQNGRLISGAGEiFSYQSTVMFECLQGFYMEGSSMVICSANNSWEPSIPKC 294
Cdd:cd00033    1 CPPPpVPENGTVTGSKGS-YSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 239-294 1.71e-09

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 53.30  E-value: 1.71e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 568911963   239 CPNP-VLQNGRlISGAGEIFSYQSTVMFECLQGFYMEGSSMVICSANNSWEPSIPKC 294
Cdd:smart00032   1 CPPPpDIENGT-VTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56
 
Name Accession Description Interval E-value
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 64-296 6.50e-42

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 147.49  E-value: 6.50e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568911963  64 YAVGEKIEYKCKKGYLYLSPYLMIATCEPNhTWVPISDagCIKVQCTMLQDPSFGKVYYidGSFSWGARAKFTCMEGYYV 143
Cdd:PHA02927  44 YNIGDTIEYLCLPGYRKQKMGPIYAKCTGT-GWTLFNQ--CIKRRCPSPRDIDNGQLDI--GGVDFGSSITYSCNSGYQL 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568911963 144 VGMSVLHCVLKGDDEAYWNGYPPHCEKIYCLPPPKIKNGTHTLTDiNVFKYHEAVSYSCDptpgpDKFSLVGTSMIFCAG 223
Cdd:PHA02927 119 IGESKSYCELGSTGSMVWNPEAPICESVKCQSPPSISNGRHNGYE-DFYTDGSVVTYSCN-----SGYSLIGNSGVLCSG 192

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568911963 224 hNTWSNsPPECKVVKCPNPVLQNGRLISGAGEIFSYQSTVMFECLQGFYMEGSSMVICSANNSWEPSIPKCLK 296
Cdd:PHA02927 193 -GEWSD-PPTCQIVKCPHPTISNGYLSSGFKRSYSYNDNVDFKCKYGYKLSGSSSSTCSPGNTWQPELPKCVR 263
PHA02639 PHA02639
EEV host range protein; Provisional
 103-296 7.92e-23

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 97.04  E-value: 7.92e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568911963 103 GCIKVQCTMLQDPSFGKVYYIDGSFSWGARAKFTCMEGYYVVGMSVLHCVlKGDDEAYWNGYPPHCEKIYCLPPPKIKNG 182
Cdd:PHA02639  16 GVKSIYCDKPDDISNGFITELMEKYEIGKLIEYTCNTDYALIGDRFRTCI-KDKNNAIWSNKAPFCMLKECNDPPSIING 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568911963 183 ThTLTDINVFKYHEAVSYSCDPTPGPdKFSLVGTSMIFCAGHNTWSNSPPECKVVKCPNPVLQNGrLISG--AGEIFSYQ 260
Cdd:PHA02639  95 K-IYNKREMYKVGDEIYYVCNEHKGV-QYSLVGNEKITCIQDKSWKPDPPICKMINCRFPALQNG-YINGipSNKKFYYK 171

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 568911963 261 STVMFECLQGFYMEGSSMVICSANNSWEPSIPKCLK 296
Cdd:PHA02639 172 TRVGFSCKSGFDLVGEKYSTCNINATWFPSIPTCVR 207
PHA02817 PHA02817
EEV Host range protein; Provisional
 168-296 1.29e-18

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 83.84  E-value: 1.29e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568911963 168 CEKIYCLPPPKIKNGtHTLTDINVFKYHEAVSYSCDPTPGPDKFSLVGTSMIFCAGHNTWSNSPPECKVVKCPNPVLQNG 247
Cdd:PHA02817  19 CDLNKCCYPPSIKNG-YIYNKKTEYNIGSNVTFFCGNNTRGVRYTLVGEKNIICEKDGKWNKEFPVCKIIRCRFPALQNG 97

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 568911963 248 rLISG--AGEIFSYQSTVMFECLQGFYMEGSSMVICSANNSWEPSIPKCLK 296
Cdd:PHA02817  98 -FVNGipDSKKFYYESEVSFSCKPGFVLIGTKYSVCGINSSWIPKVPICSR 147
PHA02831 PHA02831
EEV host range protein; Provisional
 170-361 1.88e-15

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 75.80  E-value: 1.88e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568911963 170 KIYCLPPPKIKNGtHTLTDINVFKYHEAVSYSCDPTPgPDKFSLVGTSMIFCAgHNTWSNSPPECKVVKCPNPVLQNGRL 249
Cdd:PHA02831  75 KRNCKDPVTILNG-YIKNKKDQYSFGDSVTYACKVNK-LEKYSIVGNETVKCI-NKQWVPKYPVCKLIRCKYPALQNGFL 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568911963 250 ISGAGEiFSYQSTVMFECLQGFYMEGSSMVICSANNSWEPSIPKCLKGP-----RPTHPTKPPVYNYTGYPSpreGIFSQ 324
Cdd:PHA02831 152 NVFEKK-FYYGDIVNFKCKKGFILLGSSVSTCDINSIWYPGIPKCVKDKvhneiQPNYLFDDLDEDFNNSTT---NYNMQ 227

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 568911963 325 ELDAWIIALIVITSIVGVFILCLIVLRCFEHRKKTSI 361
Cdd:PHA02831 228 QNIITIIILLSIICFIFVLGLIALFLSCNKSTLKPSI 264
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 95-301 2.44e-14

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 72.38  E-value: 2.44e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568911963  95 TWVPISDAGCIKVQCTMLQDPSFGKV-----YYIDGSFSWGARAKFTCMEGYYVVGMSVLHCVLKGDDEAYWNgyppHCE 169
Cdd:PHA02927   7 TFLTLLGIGCVLSCCTIPSRPINMKFknsveTDANANYNIGDTIEYLCLPGYRKQKMGPIYAKCTGTGWTLFN----QCI 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568911963 170 KIYCLPPPKIKNGThtlTDINVFKYHEAVSYSCDptpgpDKFSLVGTSMIFC----AGHNTWSNSPPECKVVKCPNP-VL 244
Cdd:PHA02927  83 KRRCPSPRDIDNGQ---LDIGGVDFGSSITYSCN-----SGYQLIGESKSYCelgsTGSMVWNPEAPICESVKCQSPpSI 154

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 568911963 245 QNGRLiSGAGEIFSYQSTVMFECLQGFYMEGSSMVICSANNSWEPSIPKCLKGPRPT 301
Cdd:PHA02927 155 SNGRH-NGYEDFYTDGSVVTYSCNSGYSLIGNSGVLCSGGEWSDPPTCQIVKCPHPT 210
Sushi pfam00084
Sushi repeat (SCR repeat);
109-168 9.14e-13

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 62.52  E-value: 9.14e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568911963  109 CTMLQDPSFGKVYYIDGSFSWGARAKFTCMEGYYVVGMSVLHCVLKGddeaYWNGYPPHC 168
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPTITCQEDG----TWSPPFPEC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 239-294 1.49e-10

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 56.32  E-value: 1.49e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 568911963 239 CPNP-VLQNGRLISGAGEiFSYQSTVMFECLQGFYMEGSSMVICSANNSWEPSIPKC 294
Cdd:cd00033    1 CPPPpVPENGTVTGSKGS-YSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
239-294 2.57e-10

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 55.58  E-value: 2.57e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 568911963  239 CPNP-VLQNGRlISGAGEIFSYQSTVMFECLQGFYMEGSSMVICSANNSWEPSIPKC 294
Cdd:pfam00084   1 CPPPpDIPNGK-VSATKNEYNYGASVSYECDPGYRLVGSPTITCQEDGTWSPPFPEC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 239-294 1.71e-09

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 53.30  E-value: 1.71e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 568911963   239 CPNP-VLQNGRlISGAGEIFSYQSTVMFECLQGFYMEGSSMVICSANNSWEPSIPKC 294
Cdd:smart00032   1 CPPPpDIENGT-VTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 173-235 8.77e-09

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 51.31  E-value: 8.77e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568911963 173 CLPPPKIKNGTHTLTDiNVFKYHEAVSYSCDPtpgpdKFSLVGTSMIFCAGHNTWSNSPPECK 235
Cdd:cd00033    1 CPPPPVPENGTVTGSK-GSYSYGSTVTYSCNE-----GYTLVGSSTITCTENGGWSPPPPTCE 57
Sushi pfam00084
Sushi repeat (SCR repeat);
173-234 5.54e-08

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 49.03  E-value: 5.54e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568911963  173 CLPPPKIKNGTHTLTDiNVFKYHEAVSYSCDPTpgpdkFSLVGTSMIFCAGHNTWSNSPPEC 234
Cdd:pfam00084   1 CPPPPDIPNGKVSATK-NEYNYGASVSYECDPG-----YRLVGSPTITCQEDGTWSPPFPEC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 109-169 9.04e-08

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 48.23  E-value: 9.04e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568911963 109 CTMLQDPSFGKVYYIDGSFSWGARAKFTCMEGYYVVGMSVLHCVLKGDdeayWNGYPPHCE 169
Cdd:cd00033    1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTENGG----WSPPPPTCE 57
PHA02954 PHA02954
EEV membrane glycoprotein; Provisional
 192-352 2.31e-07

EEV membrane glycoprotein; Provisional


Pssm-ID: 165263 [Multi-domain]  Cd Length: 317  Bit Score: 52.01  E-value: 2.31e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568911963 192 FKYHEAVSYSCDPtpgpdKFSLVGTSMIFCAGhNTWsNSPPECKVvKCPNPVLQNGrLISGAgeIFSYQSTVMFECLQGF 271
Cdd:PHA02954 147 YSFGEHITINCDV-----GYEVIGASYISCTA-NSW-NVIPSCQQ-KCDIPSLSNG-LISGS--TFSIGGVIHLSCKSGF 215

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568911963 272 YMEGSSMVICsANNSWEPSIPKCLKGPRPTHPTKPPVYNYTGYPSPREGIFSQE-----LDAWIIALIVITSIVGV-FIL 345
Cdd:PHA02954 216 TLTGSPSSTC-IDGKWNPVLPICVRSNEEFDPVDDGPDDETDLSKLSKDVVQYEqeiesLEATYHIIIVALTIMGViFLI 294


                 ....*..
gi 568911963 346 CLIVLRC 352
Cdd:PHA02954 295 SVIVLVC 301
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 173-234 2.36e-07

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 47.14  E-value: 2.36e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568911963   173 CLPPPKIKNGTHTLTDiNVFKYHEAVSYSCDPtpgpdKFSLVGTSMIFCAGHNTWSNSPPEC 234
Cdd:smart00032   1 CPPPPDIENGTVTSSS-GTYSYGDTVTYSCDP-----GYTLIGSSTITCLENGTWSPPPPTC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 109-168 1.16e-06

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 45.21  E-value: 1.16e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568911963   109 CTMLQDPSFGKVYYIDGSFSWGARAKFTCMEGYYVVGMSVLHCVLKGDdeayWNGYPPHC 168
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLENGT----WSPPPPTC 56
PHA02817 PHA02817
EEV Host range protein; Provisional
 104-234 1.04e-05

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 46.09  E-value: 1.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568911963 104 CIKVQCTMLQDPSFGKVYYIDGSFSWGARAKFTCMEG-----YYVVGMSVLHCvlkgDDEAYWNGYPPHCEKIYClPPPK 178
Cdd:PHA02817  19 CDLNKCCYPPSIKNGYIYNKKTEYNIGSNVTFFCGNNtrgvrYTLVGEKNIIC----EKDGKWNKEFPVCKIIRC-RFPA 93

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 568911963 179 IKNG-THTLTDINVFKYHEAVSYSCDPtpgpdKFSLVGTSMIFCAGHNTWSNSPPEC 234
Cdd:PHA02817  94 LQNGfVNGIPDSKKFYYESEVSFSCKP-----GFVLIGTKYSVCGINSSWIPKVPIC 145
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 45-98 1.81e-03

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 36.29  E-value: 1.81e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 568911963  45 CELPRPFEAMELKGTpKLFYAVGEKIEYKCKKGYLYLSPylMIATCEPNHTWVP 98
Cdd:cd00033    1 CPPPPVPENGTVTGS-KGSYSYGSTVTYSCNEGYTLVGS--STITCTENGGWSP 51
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 45-98 9.77e-03

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 34.04  E-value: 9.77e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 568911963    45 CELPRPFEAMELKGTPKLFYaVGEKIEYKCKKGYLYLSPYlmIATCEPNHTWVP 98
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYS-YGDTVTYSCDPGYTLIGSS--TITCLENGTWSP 51
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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