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Conserved domains on  [gi|568907743|ref|XP_006496583|]
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F-box only protein 36 isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
F-box_FBXO36 cd22106
F-box domain found in F-box only protein 36 (FBXO36) and similar proteins; FBXO36, also called ...
 73-118 1.32e-17

F-box domain found in F-box only protein 36 (FBXO36) and similar proteins; FBXO36, also called FBX36, likely functions as the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 438878  Cd Length: 46  Bit Score: 71.84  E-value: 1.32e-17
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 568907743  73 LERLSDRLLLKIICYLDLEDIASLSQTSSKFEKLCKSDLLWEQIVQ 118
Cdd:cd22106    1 LVRLPDKLLLYIISYLDLEDIARLSQTSKRFKKLCNSDELWEKIYM 46
 
Name Accession Description Interval E-value
F-box_FBXO36 cd22106
F-box domain found in F-box only protein 36 (FBXO36) and similar proteins; FBXO36, also called ...
 73-118 1.32e-17

F-box domain found in F-box only protein 36 (FBXO36) and similar proteins; FBXO36, also called FBX36, likely functions as the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438878  Cd Length: 46  Bit Score: 71.84  E-value: 1.32e-17
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 568907743  73 LERLSDRLLLKIICYLDLEDIASLSQTSSKFEKLCKSDLLWEQIVQ 118
Cdd:cd22106    1 LVRLPDKLLLYIISYLDLEDIARLSQTSKRFKKLCNSDELWEKIYM 46
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 73-117 5.96e-07

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 44.01  E-value: 5.96e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 568907743   73 LERLSDRLLLKIICYLDLEDIASLSQTSSKFEKLCKSDLLWEQIV 117
Cdd:pfam12937   1 LSSLPDEILLQIFSYLDPKDLLRLALVCRRWRELASDDSLWRRLC 45
 
Name Accession Description Interval E-value
F-box_FBXO36 cd22106
F-box domain found in F-box only protein 36 (FBXO36) and similar proteins; FBXO36, also called ...
 73-118 1.32e-17

F-box domain found in F-box only protein 36 (FBXO36) and similar proteins; FBXO36, also called FBX36, likely functions as the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438878  Cd Length: 46  Bit Score: 71.84  E-value: 1.32e-17
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 568907743  73 LERLSDRLLLKIICYLDLEDIASLSQTSSKFEKLCKSDLLWEQIVQ 118
Cdd:cd22106    1 LVRLPDKLLLYIISYLDLEDIARLSQTSKRFKKLCNSDELWEKIYM 46
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 73-117 5.96e-07

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 44.01  E-value: 5.96e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 568907743   73 LERLSDRLLLKIICYLDLEDIASLSQTSSKFEKLCKSDLLWEQIV 117
Cdd:pfam12937   1 LSSLPDEILLQIFSYLDPKDLLRLALVCRRWRELASDDSLWRRLC 45
F-box_FBXO3 cd22084
F-box domain found in F-box only protein 3 (FBXO3) and similar proteins; FBXO3, also called ...
 73-113 8.55e-06

F-box domain found in F-box only protein 3 (FBXO3) and similar proteins; FBXO3, also called FBX3, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. It also promotes ubiquitylation and transcriptional activity of AIRE (autoimmune regulator). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438856  Cd Length: 49  Bit Score: 41.09  E-value: 8.55e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 568907743  73 LERLSDRLLLKIICYLDLEDIASLSQTSSKFEKLCKSDLLW 113
Cdd:cd22084    1 LDDLPSDPLLNILSFLDYRDLISCSQVCRRLNQLCSHDPLW 41
F-box_SF cd09917
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
 74-108 3.34e-05

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


Pssm-ID: 438852  Cd Length: 35  Bit Score: 38.96  E-value: 3.34e-05
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 568907743  74 ERLSDRLLLKIICYLDLEDIASLSQTSSKFEKLCK 108
Cdd:cd09917    1 SDLPDEILLKILSYLDPRDLLRLSLVCKRWRELAS 35
F-box_FBXL4 cd22117
F-box domain found in F-box/LRR-repeat protein 4 (FBXL4) and similar proteins; FBXL4, also ...
 73-113 7.96e-05

F-box domain found in F-box/LRR-repeat protein 4 (FBXL4) and similar proteins; FBXL4, also called F-box and leucine-rich repeat protein 4, or F-box protein FBL4/FBL5, is part of an SCF (SKP1-cullin-F-box) protein ligase complex. It serves as a clock output molecule that regulates sleep through promotion of rhythmic degradation of the GABA(A) receptor. Biallelic pathogenic variants in FBXL4 are associated with an encephalopathic mtDNA maintenance defect syndrome that is a multi-system disease characterized by lactic acidemia, developmental delay, and hypotonia. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438889  Cd Length: 47  Bit Score: 38.37  E-value: 7.96e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 568907743  73 LERLSDRLLLKIICYLDLEDIASLSQTSSKFEKLCKSDLLW 113
Cdd:cd22117    1 FDLLPYELIQLILSYLDLPSLCRLSQTCKLFRKHCYDPLLW 41
F-box_FBXW4 cd20090
F-box domain found in F-box/WD repeat-containing protein 4 (FBXW4) and similar proteins; FBXW4, ...
 72-116 1.26e-04

F-box domain found in F-box/WD repeat-containing protein 4 (FBXW4) and similar proteins; FBXW4, also called dactylin, or F-box and WD-40 domain-containing protein 4, probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It is likely to be involved in key signaling pathways crucial for normal limb development. It may participate in Wnt signaling and act as a novel tumor suppressor that regulates important cellular processes. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438853  Cd Length: 47  Bit Score: 37.96  E-value: 1.26e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 568907743  72 YLERLSDRLLLKIICYLDLEDIASLSQTSSKFEKLCKSDLLWEQI 116
Cdd:cd20090    1 PLLDLPDDLLFLIFSYLDPASLGRLSQVCRRLYRLISRDAVWRRI 45
F-box_FBXO15 cd22093
F-box domain found in F-box only protein 15 (FBXO15) and similar proteins; FBXO15, also called ...
 73-116 2.34e-04

F-box domain found in F-box only protein 15 (FBXO15) and similar proteins; FBXO15, also called FBX15, has a novel dual molecular function by controlling transcriptional repression and being part of SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligases, which is essential for stress response, gliotoxin production and virulence in the opportunistic human pathogen Aspergillus fumigatus. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438865  Cd Length: 46  Bit Score: 37.23  E-value: 2.34e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 568907743  73 LERLSDRLLLKIICYLDLEDIASLSQTSSKFEKLCKSDLLWEQI 116
Cdd:cd22093    1 IERLPSEILLKILSYLDASSLLCISCVNKLFYQLANDNALWRKL 44
F-box_FBXO24 cd22098
F-box domain found in F-box only protein 24 (FBXO24) and similar proteins; FBXO24, also called ...
 76-116 5.82e-04

F-box domain found in F-box only protein 24 (FBXO24) and similar proteins; FBXO24, also called FBX24, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It recognizes deacetylated nucleoside diphosphate kinase A (NDPK-A) to enhance its degradation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438870  Cd Length: 47  Bit Score: 36.15  E-value: 5.82e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 568907743  76 LSDRLLLKIICYLDLEDIASLSQTSSKFEKLCKSDLLWEQI 116
Cdd:cd22098    5 LPPEILDRIISFLPVKDIVSLGQTCRYFHEVCNSEAVWRRL 45
F-box_FBXO21 cd22096
F-box domain found in F-box only protein 21 (FBXO21) and similar proteins; FBXO21, also called ...
 76-113 1.08e-03

F-box domain found in F-box only protein 21 (FBXO21) and similar proteins; FBXO21, also called FBX21, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It facilitates Lys29-linkage and activation of ASK1 (apoptosis signal-regulating kinase 1) and promotes type I interferon production upon viral infection. It also polyubiquitylates EP300-interacting inhibitor of differentiation 1 (EID1) and is required for the efficient degradation of EID1 in both cycling and quiescent cells. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438868  Cd Length: 48  Bit Score: 35.36  E-value: 1.08e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 568907743  76 LSDRLLLKIICY--LDLEDIASLSQTSSKFEKLCKSDLLW 113
Cdd:cd22096    4 LPDELLEYILCSdnLDHHDIIRLSCTCRRLREVCQSGKVW 43
F-box_FBXL1 cd22114
F-box domain found in F-box/LRR-repeat protein 1 (FBXL1) and similar proteins; FBXL1, also ...
 76-113 1.41e-03

F-box domain found in F-box/LRR-repeat protein 1 (FBXL1) and similar proteins; FBXL1, also called S-phase kinase-associated protein 2, cyclin-A/CDK2-associated protein p45, F-box protein Skp2, or p45skp2, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. It specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438886  Cd Length: 41  Bit Score: 35.08  E-value: 1.41e-03
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 568907743  76 LSDRLLLKIICYLDLEDIASLSQTSSKFEKLCKSDLLW 113
Cdd:cd22114    4 LPDELLLGIFSCLCLPDLLKVSQVCKRWYRLASDESLW 41
F-box_AtSKIP22-like cd22165
F-box domain found in Arabidopsis thaliana SKP1-interacting partner 22 (AtSKIP22) and similar ...
 72-115 2.15e-03

F-box domain found in Arabidopsis thaliana SKP1-interacting partner 22 (AtSKIP22) and similar proteins; AtSKIP22, also called F-box protein SKIP22, is a component of SCF (SKP1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It interacts with SKP1A/ASK1 and SPK1B/ASK2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438936  Cd Length: 46  Bit Score: 34.56  E-value: 2.15e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 568907743  72 YLERLSDRLLLKIICYLDLEDIASLSQTSSKFEKLCKSDLLWEQ 115
Cdd:cd22165    1 CLMRLPTELKLKILELLPGVDLARMACVCSELRFLASNDDLWKQ 44
F-box_ScMFB1-like cd22146
F-box domain found in Saccharomyces cerevisiae mitochondrial F-box protein MFB1 (ScMFB1) and ...
 73-113 3.73e-03

F-box domain found in Saccharomyces cerevisiae mitochondrial F-box protein MFB1 (ScMFB1) and similar proteins; ScMFB1 is a novel mitochondria-associated F-box protein that functions to increase mitochondrial connectivity in yeast. ScMFB1 acts as a key component of a Skp1-Cdc53/Cullin-F-box protein (SCF) ubiquitin ligase complex machinery that regulates mitochondrial dynamics throughout the yeast's entire life cycle. It interacts with Skp1p in an F-box-dependent manner. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438917  Cd Length: 42  Bit Score: 33.77  E-value: 3.73e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 568907743  73 LERLSDRLLLKIICYLDLEDIASLSQTSSKFEKLCKSDLLW 113
Cdd:cd22146    1 LLGLPLEILFEILIYLDIPDILNLSKTCRFLYVLLNDEILW 41
F-box_FBXO47 cd22112
F-box domain found in F-box only protein 47 (FBXO47) and similar proteins; FBXO47, also called ...
 73-103 3.76e-03

F-box domain found in F-box only protein 47 (FBXO47) and similar proteins; FBXO47, also called FBX47, functions as the substrate-recognition component of an SCF (SKP1-cullin-F-box) protein ligase complex. It probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It has a potential role as a tumor-suppressor gene. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438884  Cd Length: 39  Bit Score: 33.67  E-value: 3.76e-03
                         10        20        30
                 ....*....|....*....|....*....|.
gi 568907743  73 LERLSDRLLLKIICYLDLEDIASLSQTSSKF 103
Cdd:cd22112    1 FERLPLELFFMILQYLSVEDLSILSLTSKAM 31
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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