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Conserved domains on  [gi|594089559|ref|XP_006068196|]
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aquaporin-4 isoform X2 [Bubalus bubalis]

Protein Classification

MIP/aquaporin family protein( domain architecture ID 11088534)

MIP (Major Intrinsic Protein)/aquaporin family protein similar to aquaporin that permits osmotically driven movement of water in both directions, and glycerol uptake facilitator protein that mediates glycerol diffusion across the cytoplasmic membrane via a pore-type mechanism

CATH:  1.20.1080.10
Gene Ontology:  GO:0055085|GO:0015267
PubMed:  11473620|8849412|11964478
SCOP:  3000508
TCDB:  1.A.8

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 9-226 8.52e-83

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


:

Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 248.77  E-value: 8.52e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594089559    9 TQTFWKAVTAEFLAMLIFVLLSLGSTINWGGA-EKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRR 87
Cdd:pfam00230   4 SVSFLRAVIAEFLATLLFVFFGVGSALGVKKLvSSLAVSGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLVGRR 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594089559   88 ISIAKSVFYIAAQCLGAIIGAGILYLVTPPSVVGGLGVTTVHGNLSAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSI 167
Cdd:pfam00230  84 FSLLRAIFYIVAQLLGAIAGAALLYGVTVGLQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRNGSLGTV 163

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 594089559  168 A-LAIGISVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLY 226
Cdd:pfam00230 164 ApLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWKWDDHWVYWVGPFIGAALGALVY 223
 
Name Accession Description Interval E-value
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 9-226 8.52e-83

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 248.77  E-value: 8.52e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594089559    9 TQTFWKAVTAEFLAMLIFVLLSLGSTINWGGA-EKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRR 87
Cdd:pfam00230   4 SVSFLRAVIAEFLATLLFVFFGVGSALGVKKLvSSLAVSGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLVGRR 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594089559   88 ISIAKSVFYIAAQCLGAIIGAGILYLVTPPSVVGGLGVTTVHGNLSAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSI 167
Cdd:pfam00230  84 FSLLRAIFYIVAQLLGAIAGAALLYGVTVGLQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRNGSLGTV 163

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 594089559  168 A-LAIGISVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLY 226
Cdd:pfam00230 164 ApLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWKWDDHWVYWVGPFIGAALGALVY 223
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 14-229 4.60e-71

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 219.05  E-value: 4.60e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594089559  14 KAVTAEFLAMLIFVLLSLGSTINWGGAEKpLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRRISIAKS 93
Cdd:cd00333    1 RKYLAEFLGTFLLVFFGCGSVLAVKLAGG-ASGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPLIRV 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594089559  94 VFYIAAQCLGAIIGAGILYLVTPPSVVGGLGV---------TTVHGNLSAGHGLLVELIITFQLVFTIFASCDSKRTDVT 164
Cdd:cd00333   80 IPYIIAQLLGAILGAALLYGLYYGLYLEFLGAnnivagifgTYPSPGVSNGNAFFVEFIGTFILVLVVFATTDDPNGPPP 159

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 594089559 165 GSIA-LAIGISVAIGHLFAINYTGASMNPARSFGPAVIMGN---WENHWIYWVGPIIGAVLAGGLYEYV 229
Cdd:cd00333  160 GGLApLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGLarhWHYFWVYWVGPLIGAIAGALVYDYV 228
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 18-226 1.80e-66

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 207.15  E-value: 1.80e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594089559   18 AEFLAMLIFVLLSLGST--INWGGAEKPLPV-DMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRRISIAKSV 94
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSAlgVNVAGAYGAVGGgQFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594089559   95 FYIAAQCLGAIIGAGILYLVTPPSVVGGLGVTTVHGN-LSAGHGLLVELIITFQLVFTIFASCD-SKRTDVTGSIALAIG 172
Cdd:TIGR00861  81 VYIVAQLIGAILGAALLYGLTSGLFPGNLAVNGSASAgVSSGQAFFVEFIGTAILVLVIFATTDdRNRVPRGGFAPLAIG 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 594089559  173 ISVAIGHLFAINYTGASMNPARSFGPAVI--MGNWENHWIYWVGPIIGAVLAGGLY 226
Cdd:TIGR00861 161 LLVFLIHLSMGPYTGTGMNPARSLGPALFagLAGWGNHWVYWVGPIIGAILGALVY 216
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 11-230 1.93e-60

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 192.26  E-value: 1.93e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594089559  11 TFWKAVTAEFLAMLIFVLLSLGSTINWGGAekPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRRISI 90
Cdd:COG0580    1 SLMKRLLAEFLGTFILVLLGCGVVAVLAGT--KGGIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFPW 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594089559  91 AKSVFYIAAQCLGAIIGAGILYLV--------TPPSVVGGLGVTTVHGNLSAGHGLLVELIITFQLVFTIFASCDSKRTD 162
Cdd:COG0580   79 KDVLPYIIAQLLGAFLGAALVYLIygghfdatEDGGAKLGVFATSPAIGYSLGAAFLTEIIGTFVLVFVILGITDKRAAP 158

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 594089559 163 vTGSIALAIGISVAIGHLFAINYTGASMNPARSFGPAVIM------GNWENHWIYWVGPIIGAVLAGGLYEYVF 230
Cdd:COG0580  159 -GGLAPLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFHalgkggSDWGYLWVPIVAPILGAALAALLYRALF 231
PLN00166 PLN00166
aquaporin TIP2; Provisional
 14-230 2.19e-42

aquaporin TIP2; Provisional


Pssm-ID: 165733  Cd Length: 250  Bit Score: 146.24  E-value: 2.19e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594089559  14 KAVTAEFLAMLIFVLLSLGSTINWGGAEKPLPVD---MVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRRISI 90
Cdd:PLN00166  19 KAYLSEFIATLLFVFAGVGSAIAFAKLTSDAALDpagLVAVAVAHAFALFVGVSIAANISGGHLNPAVTLGLAIGGNITI 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594089559  91 AKSVFYIAAQCLGAIIGAGILYLVTPPSVVGGLGVTTvhgNLSAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSIA-L 169
Cdd:PLN00166  99 ITGFFYWIAQCLGSIVACLLLVFVTNGESVPTHGVAA---GLGAIEGVVMEIVVTFALVYTVYATAADPKKGSLGTIApI 175

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 594089559 170 AIGISVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLYEYVF 230
Cdd:PLN00166 176 AIGFIVGANILAAGPFSGGSMNPARSFGPAVVSGDFSQIWIYWVGPLVGGALAGLIYGDVF 236
 
Name Accession Description Interval E-value
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 9-226 8.52e-83

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 248.77  E-value: 8.52e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594089559    9 TQTFWKAVTAEFLAMLIFVLLSLGSTINWGGA-EKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRR 87
Cdd:pfam00230   4 SVSFLRAVIAEFLATLLFVFFGVGSALGVKKLvSSLAVSGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLVGRR 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594089559   88 ISIAKSVFYIAAQCLGAIIGAGILYLVTPPSVVGGLGVTTVHGNLSAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSI 167
Cdd:pfam00230  84 FSLLRAIFYIVAQLLGAIAGAALLYGVTVGLQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRNGSLGTV 163

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 594089559  168 A-LAIGISVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLY 226
Cdd:pfam00230 164 ApLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWKWDDHWVYWVGPFIGAALGALVY 223
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 14-229 4.60e-71

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 219.05  E-value: 4.60e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594089559  14 KAVTAEFLAMLIFVLLSLGSTINWGGAEKpLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRRISIAKS 93
Cdd:cd00333    1 RKYLAEFLGTFLLVFFGCGSVLAVKLAGG-ASGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPLIRV 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594089559  94 VFYIAAQCLGAIIGAGILYLVTPPSVVGGLGV---------TTVHGNLSAGHGLLVELIITFQLVFTIFASCDSKRTDVT 164
Cdd:cd00333   80 IPYIIAQLLGAILGAALLYGLYYGLYLEFLGAnnivagifgTYPSPGVSNGNAFFVEFIGTFILVLVVFATTDDPNGPPP 159

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 594089559 165 GSIA-LAIGISVAIGHLFAINYTGASMNPARSFGPAVIMGN---WENHWIYWVGPIIGAVLAGGLYEYV 229
Cdd:cd00333  160 GGLApLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGLarhWHYFWVYWVGPLIGAIAGALVYDYV 228
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 18-226 1.80e-66

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 207.15  E-value: 1.80e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594089559   18 AEFLAMLIFVLLSLGST--INWGGAEKPLPV-DMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRRISIAKSV 94
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSAlgVNVAGAYGAVGGgQFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594089559   95 FYIAAQCLGAIIGAGILYLVTPPSVVGGLGVTTVHGN-LSAGHGLLVELIITFQLVFTIFASCD-SKRTDVTGSIALAIG 172
Cdd:TIGR00861  81 VYIVAQLIGAILGAALLYGLTSGLFPGNLAVNGSASAgVSSGQAFFVEFIGTAILVLVIFATTDdRNRVPRGGFAPLAIG 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 594089559  173 ISVAIGHLFAINYTGASMNPARSFGPAVI--MGNWENHWIYWVGPIIGAVLAGGLY 226
Cdd:TIGR00861 161 LLVFLIHLSMGPYTGTGMNPARSLGPALFagLAGWGNHWVYWVGPIIGAILGALVY 216
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 11-230 1.93e-60

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 192.26  E-value: 1.93e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594089559  11 TFWKAVTAEFLAMLIFVLLSLGSTINWGGAekPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRRISI 90
Cdd:COG0580    1 SLMKRLLAEFLGTFILVLLGCGVVAVLAGT--KGGIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFPW 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594089559  91 AKSVFYIAAQCLGAIIGAGILYLV--------TPPSVVGGLGVTTVHGNLSAGHGLLVELIITFQLVFTIFASCDSKRTD 162
Cdd:COG0580   79 KDVLPYIIAQLLGAFLGAALVYLIygghfdatEDGGAKLGVFATSPAIGYSLGAAFLTEIIGTFVLVFVILGITDKRAAP 158

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 594089559 163 vTGSIALAIGISVAIGHLFAINYTGASMNPARSFGPAVIM------GNWENHWIYWVGPIIGAVLAGGLYEYVF 230
Cdd:COG0580  159 -GGLAPLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFHalgkggSDWGYLWVPIVAPILGAALAALLYRALF 231
PLN00166 PLN00166
aquaporin TIP2; Provisional
 14-230 2.19e-42

aquaporin TIP2; Provisional


Pssm-ID: 165733  Cd Length: 250  Bit Score: 146.24  E-value: 2.19e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594089559  14 KAVTAEFLAMLIFVLLSLGSTINWGGAEKPLPVD---MVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRRISI 90
Cdd:PLN00166  19 KAYLSEFIATLLFVFAGVGSAIAFAKLTSDAALDpagLVAVAVAHAFALFVGVSIAANISGGHLNPAVTLGLAIGGNITI 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594089559  91 AKSVFYIAAQCLGAIIGAGILYLVTPPSVVGGLGVTTvhgNLSAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSIA-L 169
Cdd:PLN00166  99 ITGFFYWIAQCLGSIVACLLLVFVTNGESVPTHGVAA---GLGAIEGVVMEIVVTFALVYTVYATAADPKKGSLGTIApI 175

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 594089559 170 AIGISVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLYEYVF 230
Cdd:PLN00166 176 AIGFIVGANILAAGPFSGGSMNPARSFGPAVVSGDFSQIWIYWVGPLVGGALAGLIYGDVF 236
PLN00027 PLN00027
aquaporin TIP; Provisional
 14-230 6.92e-42

aquaporin TIP; Provisional


Pssm-ID: 177664  Cd Length: 252  Bit Score: 144.93  E-value: 6.92e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594089559  14 KAVTAEFLAMLIFVLLSLGSTINW-----GGAEKPLPVDMVLISLCFGLSIATMVQCfgHISGGHINPAVTVAMVCTRRI 88
Cdd:PLN00027  21 KAALAEFISTLIFVFAGEGSGMAFnkltdNGSTTPAGLVAAALAHAFALFVAVSVGA--NISGGHVNPAVTFGAFIGGNI 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594089559  89 SIAKSVFYIAAQCLGAIIGAGILYLVTPPSVVGGLGVTTvhgNLSAGHGLLVELIITFQLVFTIFASC-DSKRTDVTGSI 167
Cdd:PLN00027  99 TLLRGILYWIAQLLGSVVACLLLKFSTGGLETSAFSLSS---GVGVWNAFVFEIVMTFGLVYTVYATAvDPKKGDLGIIA 175

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 594089559 168 ALAIGISVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLYEYVF 230
Cdd:PLN00027 176 PIAIGFIVGANILAGGAFDGASMNPAVSFGPAVVSWTWTNHWVYWAGPLIGGGIAGLVYELIF 238
PRK05420 PRK05420
aquaporin Z; Provisional
 14-230 2.81e-39

aquaporin Z; Provisional


Pssm-ID: 235453 [Multi-domain]  Cd Length: 231  Bit Score: 137.41  E-value: 2.81e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594089559  14 KAVTAEFLAMLIFVLLSLGSTInWGGAEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRRISIAKS 93
Cdd:PRK05420   3 KKLAAEFFGTFWLVFGGCGSAV-LAAAFPELGIGFLGVALAFGLTVLTMAYAVGHISGGHFNPAVSVGLWAGGRFPAKEL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594089559  94 VFYIAAQCLGAIIGAGILYLVTPP----SVVGGLGVTTVHGNLSAGH-----GLLVELIITFQLVFTIFASCDsKRTDVt 164
Cdd:PRK05420  82 VPYIIAQVVGGIAAAAVLYLIASGkagfDLAGSGFASNGYGEHSPGGysllaALVCEVVLTAFFLLVILGATD-KRAPA- 159

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 594089559 165 GSIALAIGISVAIGHLFAINYTGASMNPARSFGPAVIMGNW--ENHWIYWVGPIIGAVLAGGLYEYVF 230
Cdd:PRK05420 160 GFAPIAIGLALTLIHLISIPVTNTSVNPARSTGVALFVGGWalEQLWLFWVAPIVGAIIGGLIYRLLL 227
PLN00167 PLN00167
aquaporin TIP5; Provisional
 4-232 5.03e-35

aquaporin TIP5; Provisional


Pssm-ID: 215085  Cd Length: 256  Bit Score: 127.33  E-value: 5.03e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594089559   4 FKGVWTQTFWKAVTAEFLAMLIFVLLSLGSTINW-----GGAEKPLPVDMVLISLCFGLSIATMVQcfGHISGGHINPAV 78
Cdd:PLN00167  13 FQQSVTRNALRSYLAEFISTFFFVFAAVGSAMSSrklmpDAASDPSSLLIVAIANAFALSSAVYIA--ANISGGHVNPAV 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594089559  79 TVAMVCTRRISIAKSVFYIAAQCLGAIIGAGILYLVTppsVVGGLGVTTVHGNLSAGHGLLVELIITFQLVFTIFASCDS 158
Cdd:PLN00167  91 TFGMAVGGHISVPTAMFYWISQMLASVMACLFLKVTT---VGQHVPTYKIAEEMTGFGASVLEGVLTFGLVYTVYAAGDP 167

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 594089559 159 KRTDVTGSIALAIGISVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLYEYVFCP 232
Cdd:PLN00167 168 RRGLLGAIGPLAIGLVAGANVLAAGPFSGGSMNPACAFGSAVVAGSFKNQAVYWVGPLLGGAVAGLLYDNVVFP 241
PLN00026 PLN00026
aquaporin NIP; Provisional
 14-235 4.44e-33

aquaporin NIP; Provisional


Pssm-ID: 177663 [Multi-domain]  Cd Length: 298  Bit Score: 123.05  E-value: 4.44e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594089559  14 KAVTAEFLAMLIFVLLSLGSTI---NWGGAEKPlpvdmVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRRISI 90
Cdd:PLN00026  72 RKLGAEFVGTFILIFAATAGPIvnqKYDGAETL-----IGNAACAGLAVMIVILSTGHISGAHLNPSLTIAFAALRHFPW 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594089559  91 AKSVFYIAAQCLGAIIGAGILYLVTPPSVVGGLGVTTVhgnlSAGHGLLVELIITFQLVFTIFASCDSKRTdvTGSIA-L 169
Cdd:PLN00026 147 KHVPAYIAAQVSASICASFALKGVFHPFMSGGVTVPSV----STGQAFALEFIITFNLLFVVTAVATDTRA--VGELAgI 220

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 594089559 170 AIGISVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLYEYVFCPDVE 235
Cdd:PLN00026 221 AVGATVMLNILVAGPSTGGSMNPVRTLGPAVAAGNYRAIWIYLVAPTLGALAGAGTYTAVKLREED 286
PLN00182 PLN00182
putative aquaporin NIP4; Provisional
 51-254 4.06e-31

putative aquaporin NIP4; Provisional


Pssm-ID: 165748  Cd Length: 283  Bit Score: 117.70  E-value: 4.06e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594089559  51 ISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRRISIAKSVFYIAAQCLGAIIGAGILYL---VTPPSVVGglgvTT 127
Cdd:PLN00182  78 ICVTWGLIVMVMIYSTGHISGAHFNPAVTVTFAIFRRFPWYQVPLYIGAQLTGSLLASLTLRLmfnVTPEAFFG----TT 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594089559 128 VHGnlSAGHGLLVELIITFQLVFTIFASCDSKRTdvTGSIA-LAIGISVAIGHLFAINYTGASMNPARSFGPAVIMGNWE 206
Cdd:PLN00182 154 PTD--SSGQALVAEIIISFLLMFVISGVATDSRA--VGELAgIAVGMTIILNVFVAGPISGASMNPARSLGPAIVMGRYK 229

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 594089559 207 NHWIYWVGPIIGAVLAGGLYEYVFCPDVELKRRFKEA-FSKAAQQTKGS 254
Cdd:PLN00182 230 GIWVYIVGPFVGIIAGGFVYNLIRFTDKPLRELTKSAsFLRSVSQKHNA 278
PLN00184 PLN00184
aquaporin NIP1; Provisional
 12-237 3.29e-27

aquaporin NIP1; Provisional


Pssm-ID: 177778  Cd Length: 296  Bit Score: 107.41  E-value: 3.29e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594089559  12 FWKAVTAEFLAMLIFVLLSLGSTINwgGAEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRRISIA 91
Cdd:PLN00184  53 FLQKLIAEVLGTYFLVFTGCASVVV--NMQNDNVVTLPGIAIVWGLTIMVLIYSLGHISGAHINPAVTIAFASCGRFPLK 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594089559  92 KSVFYIAAQCLGAIIGAGILYLV--TPPSVVGG-----LGVTTVHGNLSAghgLLVELIITFQLVFTIFASCDSKRTdvT 164
Cdd:PLN00184 131 QVPAYVISQVIGSTLAAATLRLLfgLDHDVCSGkhdvfIGSSPVGSDLQA---FVMEFIVTFYLMFIISGVATDNRA--I 205

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 594089559 165 GSIA-LAIGISVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLYEYVFCPDVELK 237
Cdd:PLN00184 206 GELAgLAIGSTVLLNVLIAAPVSSASMNPGRSLGPAMVYGCYKGIWIYIVAPTLGAIAGAWVYNTVRYTDKPLR 279
PLN00183 PLN00183
putative aquaporin NIP7; Provisional
 56-226 2.92e-22

putative aquaporin NIP7; Provisional


Pssm-ID: 215092  Cd Length: 274  Bit Score: 93.77  E-value: 2.92e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594089559  56 GLSIATMVQCFGHISGGHINPAVTVAMVCTRRISIAKSVFYIAAQCLGAIIG---AGILYLVTPPsvvgglgVTTVHGNL 132
Cdd:PLN00183  86 GLTVVVVVFSIGSISGAHVNPSVTIAFATFGHFPWSKVPLYITAQTVGSVLAtyvGVSVYGVKAD-------LMTTKPAQ 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594089559 133 SAGHGLLVELIITFQLVFtIFASCDSKRTDVTGSIALAIGISVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYW 212
Cdd:PLN00183 159 GCSSAFWVEFIATFIVMF-LAASLTSQPQSLGHLSGFVIGIAIGLAVLITGPVSGGSMNPARSLGPAIVSWDFKDIWIYI 237

                        170
                 ....*....|....
gi 594089559 213 VGPIIGAVLAGGLY 226
Cdd:PLN00183 238 TAPTIGAVAGALMF 251
PTZ00016 PTZ00016
aquaglyceroporin; Provisional
 13-235 3.17e-20

aquaglyceroporin; Provisional


Pssm-ID: 240230 [Multi-domain]  Cd Length: 294  Bit Score: 88.26  E-value: 3.17e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594089559  13 WKAVTAEFLAMliFVLLSLGS----TINWGGAEKPLpvdmvlISLCFGLSIATMVQCF--GHISGGHINPAVTVAMVCTR 86
Cdd:PTZ00016  50 VREYVAEFLGT--FVLLFFGEgvvaTTHTVGNNGDY------LAITIGWGLGVTFGLLvsAGISGGHLNPAVTLGNAVFG 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594089559  87 RISIAKSVFYIAAQCLGAIIGAGILY--------------LVTPPSVVGGLGVTTVHGNLSAGHGLLVELIITFQLVFTI 152
Cdd:PTZ00016 122 KFPWKKLPGYFVAQLLGAFVGAACVYglyygffkdhgipeLPWETMANGFAGVFATYPREGNFYAIFSELILTAILLLVI 201

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594089559 153 FASCDSKRTDVTGSIALAIGISV-AIGHLFAINyTGASMNPARSFGP----AVIMGN----WENH--WIYWVGPIIGAVL 221
Cdd:PTZ00016 202 LAITDPNNCPAFNYLPVAVGLLVfVIGISFGGN-TGYALNPARDLGPrlfsAILWGSevftKDNYyfWVPLVAPFVGAVL 280

                        250
                 ....*....|....
gi 594089559 222 AGGLYEYVFCPDVE 235
Cdd:PTZ00016 281 GMFLYDKFIPPLIE 294
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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