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Conserved domains on  [gi|530397741|ref|XP_005271437|]
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transcriptional coactivator YAP1 isoform X2 [Homo sapiens]

Protein Classification

WW domain-containing protein( domain architecture ID 10078884)

WW domain-containing protein; the WW domain mediates protein-protein interaction via proline-rich motifs, such as PPxY; similar to mammalian Yes-associated protein 1 (YAP1) which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis

CATH:  2.20.70.10
Gene Ontology:  GO:0005515
PubMed:  22201747|9029943
SCOP:  3001621

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WW smart00456
Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds ...
 231-263 1.51e-10

Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds proline-rich polypeptides.


:

Pssm-ID: 197736 [Multi-domain]  Cd Length: 33  Bit Score: 56.07  E-value: 1.51e-10
                           10        20        30
                   ....*....|....*....|....*....|...
gi 530397741   231 PLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRL 263
Cdd:smart00456   1 PLPPGWEERKDPDGRPYYYNHETKETQWEKPRE 33
WW cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; ...
 174-203 4.06e-10

Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.


:

Pssm-ID: 238122 [Multi-domain]  Cd Length: 31  Bit Score: 54.84  E-value: 4.06e-10
                         10        20        30
                 ....*....|....*....|....*....|
gi 530397741 174 PAGWEMAKTSSGQRYFLNHIDQTTTWQDPR 203
Cdd:cd00201    1 PPGWEERWDPDGRVYYYNHNTKETQWEDPR 30
 
Name Accession Description Interval E-value
WW smart00456
Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds ...
 231-263 1.51e-10

Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds proline-rich polypeptides.


Pssm-ID: 197736 [Multi-domain]  Cd Length: 33  Bit Score: 56.07  E-value: 1.51e-10
                           10        20        30
                   ....*....|....*....|....*....|...
gi 530397741   231 PLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRL 263
Cdd:smart00456   1 PLPPGWEERKDPDGRPYYYNHETKETQWEKPRE 33
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
 232-261 2.01e-10

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 55.59  E-value: 2.01e-10
                          10        20        30
                  ....*....|....*....|....*....|
gi 530397741  232 LPDGWEQAMTQDGEIYYINHKNKTTSWLDP 261
Cdd:pfam00397   1 LPPGWEERWDPDGRVYYYNHETGETQWEKP 30
WW cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; ...
 233-263 2.97e-10

Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.


Pssm-ID: 238122 [Multi-domain]  Cd Length: 31  Bit Score: 55.23  E-value: 2.97e-10
                         10        20        30
                 ....*....|....*....|....*....|.
gi 530397741 233 PDGWEQAMTQDGEIYYINHKNKTTSWLDPRL 263
Cdd:cd00201    1 PPGWEERWDPDGRVYYYNHNTKETQWEDPRE 31
WW cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; ...
 174-203 4.06e-10

Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.


Pssm-ID: 238122 [Multi-domain]  Cd Length: 31  Bit Score: 54.84  E-value: 4.06e-10
                         10        20        30
                 ....*....|....*....|....*....|
gi 530397741 174 PAGWEMAKTSSGQRYFLNHIDQTTTWQDPR 203
Cdd:cd00201    1 PPGWEERWDPDGRVYYYNHNTKETQWEDPR 30
WW smart00456
Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds ...
 172-203 5.66e-10

Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds proline-rich polypeptides.


Pssm-ID: 197736 [Multi-domain]  Cd Length: 33  Bit Score: 54.14  E-value: 5.66e-10
                           10        20        30
                   ....*....|....*....|....*....|..
gi 530397741   172 PLPAGWEMAKTSSGQRYFLNHIDQTTTWQDPR 203
Cdd:smart00456   1 PLPPGWEERKDPDGRPYYYNHETKETQWEKPR 32
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
 173-202 5.53e-09

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 51.35  E-value: 5.53e-09
                          10        20        30
                  ....*....|....*....|....*....|
gi 530397741  173 LPAGWEMAKTSSGQRYFLNHIDQTTTWQDP 202
Cdd:pfam00397   1 LPPGWEERWDPDGRVYYYNHETGETQWEKP 30
HUL4 COG5021
Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];
173-268 1.05e-05

Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227354 [Multi-domain]  Cd Length: 872  Bit Score: 48.22  E-value: 1.05e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530397741 173 LPAGWEMAKTSSGQRYFLNHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSASGPLPDGWEQAMTQDGEIYYINHK 252
Cdd:COG5021  388 KPTGWSSSIEDLGQFLFSDFLTSSSTYEDLRREQLGRESDESFYVASNVQQQRASREGPLLSGWKTRLNNLYRFYFVEHR 467

                         90
                 ....*....|....*.
gi 530397741 253 NKTTSWLDPRLDPRFG 268
Cdd:COG5021  468 KKTLTKNDSRLGSFIS 483
 
Name Accession Description Interval E-value
WW smart00456
Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds ...
 231-263 1.51e-10

Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds proline-rich polypeptides.


Pssm-ID: 197736 [Multi-domain]  Cd Length: 33  Bit Score: 56.07  E-value: 1.51e-10
                           10        20        30
                   ....*....|....*....|....*....|...
gi 530397741   231 PLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRL 263
Cdd:smart00456   1 PLPPGWEERKDPDGRPYYYNHETKETQWEKPRE 33
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
 232-261 2.01e-10

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 55.59  E-value: 2.01e-10
                          10        20        30
                  ....*....|....*....|....*....|
gi 530397741  232 LPDGWEQAMTQDGEIYYINHKNKTTSWLDP 261
Cdd:pfam00397   1 LPPGWEERWDPDGRVYYYNHETGETQWEKP 30
WW cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; ...
 233-263 2.97e-10

Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.


Pssm-ID: 238122 [Multi-domain]  Cd Length: 31  Bit Score: 55.23  E-value: 2.97e-10
                         10        20        30
                 ....*....|....*....|....*....|.
gi 530397741 233 PDGWEQAMTQDGEIYYINHKNKTTSWLDPRL 263
Cdd:cd00201    1 PPGWEERWDPDGRVYYYNHNTKETQWEDPRE 31
WW cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; ...
 174-203 4.06e-10

Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.


Pssm-ID: 238122 [Multi-domain]  Cd Length: 31  Bit Score: 54.84  E-value: 4.06e-10
                         10        20        30
                 ....*....|....*....|....*....|
gi 530397741 174 PAGWEMAKTSSGQRYFLNHIDQTTTWQDPR 203
Cdd:cd00201    1 PPGWEERWDPDGRVYYYNHNTKETQWEDPR 30
WW smart00456
Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds ...
 172-203 5.66e-10

Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds proline-rich polypeptides.


Pssm-ID: 197736 [Multi-domain]  Cd Length: 33  Bit Score: 54.14  E-value: 5.66e-10
                           10        20        30
                   ....*....|....*....|....*....|..
gi 530397741   172 PLPAGWEMAKTSSGQRYFLNHIDQTTTWQDPR 203
Cdd:smart00456   1 PLPPGWEERKDPDGRPYYYNHETKETQWEKPR 32
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
 173-202 5.53e-09

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 51.35  E-value: 5.53e-09
                          10        20        30
                  ....*....|....*....|....*....|
gi 530397741  173 LPAGWEMAKTSSGQRYFLNHIDQTTTWQDP 202
Cdd:pfam00397   1 LPPGWEERWDPDGRVYYYNHETGETQWEKP 30
HUL4 COG5021
Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];
173-268 1.05e-05

Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227354 [Multi-domain]  Cd Length: 872  Bit Score: 48.22  E-value: 1.05e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530397741 173 LPAGWEMAKTSSGQRYFLNHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSASGPLPDGWEQAMTQDGEIYYINHK 252
Cdd:COG5021  388 KPTGWSSSIEDLGQFLFSDFLTSSSTYEDLRREQLGRESDESFYVASNVQQQRASREGPLLSGWKTRLNNLYRFYFVEHR 467

                         90
                 ....*....|....*.
gi 530397741 253 NKTTSWLDPRLDPRFG 268
Cdd:COG5021  468 KKTLTKNDSRLGSFIS 483
PRP40 COG5104
Splicing factor [RNA processing and modification];
177-261 2.51e-04

Splicing factor [RNA processing and modification];


Pssm-ID: 227435 [Multi-domain]  Cd Length: 590  Bit Score: 43.53  E-value: 2.51e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530397741 177 WEMAKTSSGQRYFLNHIDQTTTWQDPrkamlsqmnvtaptsppvqQNMMNSASGPLP-DGWEQAMTQDGEIYYINHKNKT 255
Cdd:COG5104   17 WEELKAPDGRIYYYNKRTGKSSWEKP-------------------KELLKGSEEDLDvDPWKECRTADGKVYYYNSITRE 77


                 ....*.
gi 530397741 256 TSWLDP 261
Cdd:COG5104   78 SRWKIP 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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