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Conserved domains on  [gi|530399650|ref|XP_005268650|]
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PR domain zinc finger protein 4 isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PR-SET_PRDM4 cd19189
PR-SET domain found in PR domain zinc finger protein 4 (PRDM4) and similar proteins; PRDM4 ...
 405-544 3.38e-92

PR-SET domain found in PR domain zinc finger protein 4 (PRDM4) and similar proteins; PRDM4 (also termed PR domain-containing protein 4, or PFM1) may function as a transcription factor involved in cell differentiation.


:

Pssm-ID: 380966  Cd Length: 133  Bit Score: 285.13  E-value: 3.38e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530399650 405 RARLSLPKQLVLRQSIVGAEVvgvlpltGVWTGETIPVRTCFGPLIGQQSHSMEVAEWTDKAVNHIWKIYHNGVLEFCII 484
Cdd:cd19189    1 RARLSLPRQLYLRQSETGAEV-------GVWTKETIPVRTCFGPLIGQQSHSAEVADWTDKAAPHIWKIYHNDVLEFCII 73

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 530399650 485 TTDENECNWMMFVRKARNREEQNLVAYPHDGKIFFCTSQDIPPENELLFYYSRDYAQQIG 544
Cdd:cd19189   74 TTDENECNWMMFVRKARTREEQNLVAYPHDGKIYFCTSRDIPPDQELLFYYSRDYARQLG 133
zf_PR_Knuckle pfam18445
PR zinc knuckle motif; This is a zinc knuckle motif found in PRDM4 (Schwann cell factor 1, ...
 365-402 1.32e-23

PR zinc knuckle motif; This is a zinc knuckle motif found in PRDM4 (Schwann cell factor 1, SC-1), a member of the PR protein family. PRDM4 is a transcriptional regulator that has been implied in transduction of nerve growth factor signals via the p75 neurotrophin receptor and in cell growth arrest. The short motif is also present in several other PR proteins including human PRDM6 (PRISM), PRDM7, PRDM9 (meisetz), PRDM10 (tristanin), PRDM11, and PRDM15. The conservation of cysteine and histidine residues suggested that this 20 amino acid motif binds zinc, hence the name 'PR zinc knuckle' to distinguish it from the longer (30 amino acid) C2H2-like zinc fingers that are located C-terminally of the PR domain. The PR zinc knuckle fold is similar to that of Gag-knuckles (a beta-hairpin providing two zinc ligands followed by a short helix or a loop providing the other two zinc ligands) and zinc ribbons (two beta-hairpins, each providing two zinc ligands).


:

Pssm-ID: 375871  Cd Length: 38  Bit Score: 93.89  E-value: 1.32e-23
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 530399650  365 NKENMATLFTIWCTLCDRAYPSDCPEHGPVTFVPDTPI 402
Cdd:pfam18445   1 NKENMATAFTIWCTLCERSYPSDCPEHGPVTFIPDTPI 38
zf-H2C2_2 pfam13465
Zinc-finger double domain;
639-664 8.65e-06

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 42.74  E-value: 8.65e-06
                          10        20
                  ....*....|....*....|....*.
gi 530399650  639 NLRTHLKIHTGQKNYRCTLCDKSFTQ 664
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
667-690 3.29e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 3.29e-04
                          10        20
                  ....*....|....*....|....
gi 530399650  667 HLESHMVIHTGEKNLKCDYCDKLF 690
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
695-720 3.14e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 3.14e-03
                          10        20
                  ....*....|....*....|....*.
gi 530399650  695 DLKQHVLIHTQERQIKCPKCDKLFLR 720
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
PR-SET_PRDM4 cd19189
PR-SET domain found in PR domain zinc finger protein 4 (PRDM4) and similar proteins; PRDM4 ...
 405-544 3.38e-92

PR-SET domain found in PR domain zinc finger protein 4 (PRDM4) and similar proteins; PRDM4 (also termed PR domain-containing protein 4, or PFM1) may function as a transcription factor involved in cell differentiation.


Pssm-ID: 380966  Cd Length: 133  Bit Score: 285.13  E-value: 3.38e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530399650 405 RARLSLPKQLVLRQSIVGAEVvgvlpltGVWTGETIPVRTCFGPLIGQQSHSMEVAEWTDKAVNHIWKIYHNGVLEFCII 484
Cdd:cd19189    1 RARLSLPRQLYLRQSETGAEV-------GVWTKETIPVRTCFGPLIGQQSHSAEVADWTDKAAPHIWKIYHNDVLEFCII 73

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 530399650 485 TTDENECNWMMFVRKARNREEQNLVAYPHDGKIFFCTSQDIPPENELLFYYSRDYAQQIG 544
Cdd:cd19189   74 TTDENECNWMMFVRKARTREEQNLVAYPHDGKIYFCTSRDIPPDQELLFYYSRDYARQLG 133
zf_PR_Knuckle pfam18445
PR zinc knuckle motif; This is a zinc knuckle motif found in PRDM4 (Schwann cell factor 1, ...
 365-402 1.32e-23

PR zinc knuckle motif; This is a zinc knuckle motif found in PRDM4 (Schwann cell factor 1, SC-1), a member of the PR protein family. PRDM4 is a transcriptional regulator that has been implied in transduction of nerve growth factor signals via the p75 neurotrophin receptor and in cell growth arrest. The short motif is also present in several other PR proteins including human PRDM6 (PRISM), PRDM7, PRDM9 (meisetz), PRDM10 (tristanin), PRDM11, and PRDM15. The conservation of cysteine and histidine residues suggested that this 20 amino acid motif binds zinc, hence the name 'PR zinc knuckle' to distinguish it from the longer (30 amino acid) C2H2-like zinc fingers that are located C-terminally of the PR domain. The PR zinc knuckle fold is similar to that of Gag-knuckles (a beta-hairpin providing two zinc ligands followed by a short helix or a loop providing the other two zinc ligands) and zinc ribbons (two beta-hairpins, each providing two zinc ligands).


Pssm-ID: 375871  Cd Length: 38  Bit Score: 93.89  E-value: 1.32e-23
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 530399650  365 NKENMATLFTIWCTLCDRAYPSDCPEHGPVTFVPDTPI 402
Cdd:pfam18445   1 NKENMATAFTIWCTLCERSYPSDCPEHGPVTFIPDTPI 38
zf-H2C2_2 pfam13465
Zinc-finger double domain;
639-664 8.65e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 42.74  E-value: 8.65e-06
                          10        20
                  ....*....|....*....|....*.
gi 530399650  639 NLRTHLKIHTGQKNYRCTLCDKSFTQ 664
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
667-690 3.29e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 3.29e-04
                          10        20
                  ....*....|....*....|....
gi 530399650  667 HLESHMVIHTGEKNLKCDYCDKLF 690
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 433-540 9.15e-04

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 40.01  E-value: 9.15e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530399650   433 GVWTGETIPVRTCFGPLIG-----QQSHSMEVAEWTDKAVNH-IWKIYhngvLEFCIITTDENecNWMMFVRKARNREEQ 506
Cdd:smart00317  14 GVRATEDIPKGEFIGEYVGeiitsEEAEERPKAYDTDGAKAFyLFDID----SDLCIDARRKG--NLARFINHSCEPNCE 87

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 530399650   507 NL-VAYPHDGKIFFCTSQDIPPENELLFYYSRDYA 540
Cdd:smart00317  88 LLfVEVNGDDRIVIFALRDIKPGEELTIDYGSDYA 122
zf-H2C2_2 pfam13465
Zinc-finger double domain;
695-720 3.14e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 3.14e-03
                          10        20
                  ....*....|....*....|....*.
gi 530399650  695 DLKQHVLIHTQERQIKCPKCDKLFLR 720
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
PR-SET_PRDM4 cd19189
PR-SET domain found in PR domain zinc finger protein 4 (PRDM4) and similar proteins; PRDM4 ...
 405-544 3.38e-92

PR-SET domain found in PR domain zinc finger protein 4 (PRDM4) and similar proteins; PRDM4 (also termed PR domain-containing protein 4, or PFM1) may function as a transcription factor involved in cell differentiation.


Pssm-ID: 380966  Cd Length: 133  Bit Score: 285.13  E-value: 3.38e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530399650 405 RARLSLPKQLVLRQSIVGAEVvgvlpltGVWTGETIPVRTCFGPLIGQQSHSMEVAEWTDKAVNHIWKIYHNGVLEFCII 484
Cdd:cd19189    1 RARLSLPRQLYLRQSETGAEV-------GVWTKETIPVRTCFGPLIGQQSHSAEVADWTDKAAPHIWKIYHNDVLEFCII 73

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 530399650 485 TTDENECNWMMFVRKARNREEQNLVAYPHDGKIFFCTSQDIPPENELLFYYSRDYAQQIG 544
Cdd:cd19189   74 TTDENECNWMMFVRKARTREEQNLVAYPHDGKIYFCTSRDIPPDQELLFYYSRDYARQLG 133
PR-SET_PRDM1 cd19187
PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins; PRDM1 ...
 409-541 4.39e-33

PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins; PRDM1 (also termed BLIMP-1, beta-interferon gene positive regulatory domain I-binding factor, PR domain-containing protein 1, positive regulatory domain I-binding factor 1, PRDI-BF1, or PRDI-binding factor 1) acts as a transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs.


Pssm-ID: 380964 [Multi-domain]  Cd Length: 128  Bit Score: 123.98  E-value: 4.39e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530399650 409 SLPKQLVLRQSIVGAEVVGVlpltgvWTGETIPVRTCFGPLIGQQSHSMEVAEWTDKavNHIWKIYHNGVLEFCIITTDE 488
Cdd:cd19187    2 SLPRNLTLKYSSVGREVLGV------WSSDYIPRGTRFGPLVGEIYTNDPVPKGANR--KYFWRIYSNGEFYHYIDGFDP 73

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 530399650 489 NECNWMMFVRKARNREEQNLVAYPHDGKIFFCTSQDIPPENELLFYYSRDYAQ 541
Cdd:cd19187   74 SKSNWMRYVNPAHSLQEQNLVACQIGMNIYFYTVKPIPPNQELLVWYCREFAR 126
PR-SET_PRDM10 cd19194
PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins; PRDM10 ...
 405-544 4.02e-32

PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins; PRDM10 (also termed PR domain-containing protein 10, or tristanin) may be involved in transcriptional regulation.


Pssm-ID: 380971  Cd Length: 128  Bit Score: 121.30  E-value: 4.02e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530399650 405 RARLSLPKQLVLRQSivgaevvgVLPLTGVWTGETIPVRTCFGPLIGQQSHSMEVaewTDKAVNHIWKIYHNGVlEFCII 484
Cdd:cd19194    1 RARASLPLILQIFRF--------GETLGGVFAKRRIPKRTQFGPLEGPLVKKSEL---KDNKIHPLELEEDDGE-DLYFD 68

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 530399650 485 TTDENECNWMMFVRKARNREEQNLVAYPHDGKIFFCTSQDIPPENELLFYYSRDYAQQIG 544
Cdd:cd19194   69 LSDENKCNWMMFVRPAQNHLEQNLVAYQYGQEIYFTTIKNIEPKQELKVWYAASYAEFLG 128
PR-SET_PRDM15 cd19199
PR-SET domain found in PR domain zinc finger protein 15 (PRDM15) and similar proteins; PRDM15 ...
 404-543 9.47e-32

PR-SET domain found in PR domain zinc finger protein 15 (PRDM15) and similar proteins; PRDM15 (also termed PR domain-containing protein 15, or zinc finger protein 298 (ZNF298)) may be involved in transcriptional regulation. It plays an essential role as a chromatin factor that modulates the transcription of upstream regulators of WNT and MAPK-ERK signaling to safeguard naive pluripotency.


Pssm-ID: 380976  Cd Length: 126  Bit Score: 119.83  E-value: 9.47e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530399650 404 SRARLSLPKQLVLRQSIVGAEvvgvlpltGVWTGETIPVRTCFGPLIGQqshsmEVAEWTDKAVNHIwKIYHNGVLEFCI 483
Cdd:cd19199    1 SRARSSLPDNLEIRQLEDGSE--------GVFALVPLVKRTQFGPFEAK-----RVARLDGFAVFPL-KVFEKDGSVVYL 66

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 530399650 484 ITTDENECNWMMFVRKARNREEQNLVAYPHDGKIFFCTSQDIPPENELLFYYSRDYAQQI 543
Cdd:cd19199   67 DTSNEDDCNWMMFVRPATDVEHQNLTAYQQGEDIYFTTSRDIQPGAELRVWYAAFYAKKM 126
PR-SET_PRDM-like cd10534
PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family ...
 410-536 1.53e-28

PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family of proteins is defined based on the conserved N-terminal PR domain, which is closely related to the Su(var)3-9, enhancer of zeste, and trithorax (SET) domains of histone methyltransferases, and is specifically called PR-SET domain. The family consists of 17 members in primates. PRDMs play diverse roles in cell-cycle regulation, differentiation, and meiotic recombination. The family also contains zinc finger protein ZFPM1 and ZFPM2. ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380932  Cd Length: 83  Bit Score: 109.21  E-value: 1.53e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530399650 410 LPKQLVLRQSIVGAEVVGVlpltgvWTGETIPVRTCFGPLIGQQshsmevaewtdkavnhiwkiyhngvlefciittden 489
Cdd:cd10534    1 LPAGLELVLSSIPEGGLGV------FARRTIPAGTRFGPLEGVV------------------------------------ 38

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 530399650 490 ecNWMMFVRKARNREEQNLVAYPHDGKIFFCTSQDIPPENELLFYYS 536
Cdd:cd10534   39 --NWMRFVRPARNEEEQNLVAYQHGGQIYFRTTRDIPPGEELLVWYS 83
PR-SET_PRDM7_9 cd19193
PR-SET domain found in PR domain zinc finger protein 7 (PRDM7) and 9 (PRDM9) and similar ...
 407-544 1.57e-28

PR-SET domain found in PR domain zinc finger protein 7 (PRDM7) and 9 (PRDM9) and similar proteins; PRDM7 (also termed PR domain-containing protein 7) is a primate-specific histone methyltransferase that is the result of a recent gene duplication of PRDM9. It selectively catalyzes the trimethylation of H3 lysine 4 (H3K4me3). PRDM9 (also termed PR domain-containing protein 9) is a histone methyltransferase that specifically trimethylates 'Lys-4' of histone H3 (H3K4me3) during meiotic prophase and is essential for proper meiotic progression. It also efficiently mono-, di-, and trimethylates H3K36. Aberrant PRDM9 expression is assciated with with genome instability in cancer.


Pssm-ID: 380970 [Multi-domain]  Cd Length: 129  Bit Score: 110.79  E-value: 1.57e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530399650 407 RLSLPKQLVLRQS-IVGAevvGVlpltGVWTGETIPVRTCFGPLIGQQSHSMEVAEwtdkaVNHIWKIYHNGVLEFCIIT 485
Cdd:cd19193    1 RLTLPPGLSIKRSsIPGA---GL----GVWAEAPIPKGMVFGPYEGEIVEDEEAAD-----SGYSWQIYKGGKLSHYIDA 68

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 530399650 486 TDENECNWMMFVRKARNREEQNLVAYPHDGKIFFCTSQDIPPENELLFYYSRDYAQQIG 544
Cdd:cd19193   69 KDESKSNWMRYVNCARNEEEQNLVAFQYRGKIYYRTCKDIAPGTELLVWYGDEYAKELG 127
zf_PR_Knuckle pfam18445
PR zinc knuckle motif; This is a zinc knuckle motif found in PRDM4 (Schwann cell factor 1, ...
 365-402 1.32e-23

PR zinc knuckle motif; This is a zinc knuckle motif found in PRDM4 (Schwann cell factor 1, SC-1), a member of the PR protein family. PRDM4 is a transcriptional regulator that has been implied in transduction of nerve growth factor signals via the p75 neurotrophin receptor and in cell growth arrest. The short motif is also present in several other PR proteins including human PRDM6 (PRISM), PRDM7, PRDM9 (meisetz), PRDM10 (tristanin), PRDM11, and PRDM15. The conservation of cysteine and histidine residues suggested that this 20 amino acid motif binds zinc, hence the name 'PR zinc knuckle' to distinguish it from the longer (30 amino acid) C2H2-like zinc fingers that are located C-terminally of the PR domain. The PR zinc knuckle fold is similar to that of Gag-knuckles (a beta-hairpin providing two zinc ligands followed by a short helix or a loop providing the other two zinc ligands) and zinc ribbons (two beta-hairpins, each providing two zinc ligands).


Pssm-ID: 375871  Cd Length: 38  Bit Score: 93.89  E-value: 1.32e-23
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 530399650  365 NKENMATLFTIWCTLCDRAYPSDCPEHGPVTFVPDTPI 402
Cdd:pfam18445   1 NKENMATAFTIWCTLCERSYPSDCPEHGPVTFIPDTPI 38
PR-SET_PRDM14 cd19198
PR-SET domain found in PR domain zinc finger protein 14 (PRDM14) and similar proteins; PRDM14 ...
 408-546 6.73e-23

PR-SET domain found in PR domain zinc finger protein 14 (PRDM14) and similar proteins; PRDM14 (also termed PR domain-containing protein 14) acts as a transcription factor that has both positive and negative roles on transcription. It acts on regulating epigenetic modifications in the cells, playing a key role in the regulation of cell pluripotency, epigenetic reprogramming, differentiation and development. Aberrant PRDM14 expression is associated with tumorigenesis, cell migration and cell chemotherapeutic drugs resistance.


Pssm-ID: 380975  Cd Length: 133  Bit Score: 95.16  E-value: 6.73e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530399650 408 LSLPKQLVLRQSivgaeVVGVLPLTGVWTGETIPVRTCFGPLIGQQSHSMEVAEWTDKAvnHIWKIYHNGVLEFCIITTD 487
Cdd:cd19198    1 LDLPEGLRVLQT-----SFGGTPHYGVFCKKTIPKGTRFGPFRGRVVNTSEIKTYDDNS--FMWEIFEDGKLSHFIDGRG 73

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 530399650 488 ENEcNWMMFVRKARNREEQNLVAYPHDGKIFFCTSQDIPPENELLFYYSRDYAQQIGVP 546
Cdd:cd19198   74 STG-NWMSYVNCARYAEEQNLIAIQCQGQIFYESCKEILQGQELLVWYGDCYLQFMGIP 131
PR-SET_PRDM12 cd19196
PR-SET domain found in PR domain zinc finger protein 12 (PRDM12) and similar proteins; PRDM12 ...
 410-546 6.36e-21

PR-SET domain found in PR domain zinc finger protein 12 (PRDM12) and similar proteins; PRDM12 (also termed PR domain-containing protein 12) acts as a transcription factor that is involved in the positive regulation of histone H3-K9 dimethylation.


Pssm-ID: 380973 [Multi-domain]  Cd Length: 130  Bit Score: 89.34  E-value: 6.36e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530399650 410 LPKQLVLRQSIVGAEVVGVLPLTgvWTGETipvrTCFGPLIGQQSHSMEVAEWTDKavNHIWKIYH-NGVLEFCIITTDE 488
Cdd:cd19196    1 LPSQVIIAQSSIPGAGLGVFSKT--WIKEG----TEMGPYTGRIVSPEDVDPCKNN--NLMWEVFNeDGTVSHFIDASQE 72

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 530399650 489 NECNWMMFVRKARNREEQNLVAYPHDGKIFFCTSQDIPPENELLFYYSRDYAQQIGVP 546
Cdd:cd19196   73 NHRSWMTFVNCARNEQEQNLEVVQIGESIYYRAIKDIPPDQELLVWYGNSYNTFLGIP 130
PR-SET_PRDM2 cd19188
PR-SET domain found in PR domain zinc finger protein 2 (PRDM2) and similar proteins; PRDM2 ...
 410-535 1.15e-18

PR-SET domain found in PR domain zinc finger protein 2 (PRDM2) and similar proteins; PRDM2 (also termed GATA-3-binding protein G3B, lysine N-methyltransferase 8, MTB-or MTE-binding protein, PR domain-containing protein 2, retinoblastoma protein-interacting zinc finger protein, or zinc finger protein RIZ) is S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. It may function as a DNA-binding transcription factor.


Pssm-ID: 380965  Cd Length: 123  Bit Score: 82.49  E-value: 1.15e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530399650 410 LPKQLVLRQSIVGAevvgvlPLTGVWTGETIPVRTCFGPLIGQQSHSMEVAEWTdkavnHIWKIYHNGVLEFCIITTDEN 489
Cdd:cd19188    4 LPEELELKPSAVDK------TRIGVWAKKSIPKGRKFGPFVGEKKKRSQVKNNV-----YMWEIYGPKRGWMCVDASDPT 72

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 530399650 490 ECNWMMFVRKARNREEQNLVAYPHDGKIFFCTSQDIPPENELLFYY 535
Cdd:cd19188   73 KGNWLRYVNWARSGEEQNLFPLQINRAIYYKTLKPIAPGEELLCWY 118
PR-SET_PRDM6 cd19191
PR-SET domain found in PR domain zinc finger protein 6 (PRDM6) and similar proteins; PRDM6 ...
 410-543 1.35e-17

PR-SET domain found in PR domain zinc finger protein 6 (PRDM6) and similar proteins; PRDM6 (also termed PR domain-containing protein 6) is a putative histone-lysine N-methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. It may specifically methylate 'Lys-20' of histone H4 when associated with other proteins and in vitro.


Pssm-ID: 380968  Cd Length: 128  Bit Score: 79.83  E-value: 1.35e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530399650 410 LPKQLVLRQSIVGAEvvgvlpLTGVWTGETIPVRTCFGPLIGQQSHSMEVAewtdKAVN---HIWKIY-HNGVLEFCIIT 485
Cdd:cd19191    1 LPDEVCLCTSSIPGL------GYGICAAQRIPQGTWIGPFEGVLVSPEKQI----GAVRntqHLWEIYdQEGTLQHFIDG 70

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 530399650 486 TDENECNWMMFVRKARNREEQNLVAYPHDGKIFFCTSQDIPPENELLFYYSRDYAQQI 543
Cdd:cd19191   71 GDPSKSSWMRYIRCARHCGEQNLTVVQYRGCIFYRACRDIPRGTELLVWYDDSYTSFF 128
PR-SET_PRDM16_PRDM3 cd19200
PR-SET domain found in PR domain zinc finger protein 16 (PRDM16), MDS1 and EVI1 complex locus ...
 408-534 4.72e-16

PR-SET domain found in PR domain zinc finger protein 16 (PRDM16), MDS1 and EVI1 complex locus protein and similar proteins; PRDM16 (also termed PR domain-containing protein 16, transcription factor MEL1, or MDS1/EVI1-like gene 1) functions as a transcriptional regulator. PRDM16 is preferentially expressed by hematopoietic and neuronal stem cells. It is closely related to paralog of PRDM3 (also termed MDS1 and EVI1 complex locus protein, ecotropic virus integration site 1 protein, EVI-1, myelodysplasia syndrome 1 protein, myelodysplasia syndrome-associated protein 1, or MECOM) which is a nuclear transcription factor essential for the proliferation/maintenance of hematopoietic stem cells (HSCs). PRDM3 and PRDM16 are both directly linked to various aspects of oncogenic transformation.


Pssm-ID: 380977  Cd Length: 135  Bit Score: 75.48  E-value: 4.72e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530399650 408 LSLPKQLVLRQS-IVGAEVvgvlpltGVWTGETIPVRTCFGPLIGQQSHSMEVAewtdkavNHIWKIY-HNGVLEFCIit 485
Cdd:cd19200    8 IPIPPDFELRESaAVGAGL-------GVWTKVRIEVGEKFGPFVGVQRSSVKDP-------TYAWEIVdEFGKVKFWI-- 71

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 530399650 486 tDENEC---NWMMFVRKARNREEQNLVAYPHDGKIFFCTSQDIPPENELLFY 534
Cdd:cd19200   72 -DASEPgtgNWMKYIRSAPSCEQQNLMACQIDEQIYYKVVRDIQPGEELLLY 122
PR-SET_PRDM8 cd19192
PR-SET domain found in PR domain zinc finger protein 8 (PRDM8) and similar proteins; PRDM8 ...
 422-540 1.76e-14

PR-SET domain found in PR domain zinc finger protein 8 (PRDM8) and similar proteins; PRDM8 (also termed PR domain-containing protein 8) may function as histone methyltransferase, preferentially acting on 'Lys-9' of histone H3.


Pssm-ID: 380969  Cd Length: 131  Bit Score: 70.92  E-value: 1.76e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530399650 422 GAEVVGVLPLTGVWTGETIPVRTCFGPLIGqqSHSMeVAEWTDKAVNHiwKIYHNGVLEFCIITTDENEC----NWMMFV 497
Cdd:cd19192   10 GSKSVLTDIFTSVVTTTDIPAGTIFGPCVL--SFTL-GYDIADIALKT--TDKRVVPYIFRVDTGACNGSsepsDWLRLV 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 530399650 498 RKARNREEQNLVAY-PHDGKIFFCTSQDIPPENELLFYYSRDYA 540
Cdd:cd19192   85 QPARDRHEQNLEAFrKNEGQVYFRTLRRIRKGEELLVWYSDELA 128
PR-SET_PRDM3 cd19214
PR-SET domain found in MDS1 and EVI1 complex locus protein and similar proteins; PRDM3 (also ...
 389-547 3.71e-14

PR-SET domain found in MDS1 and EVI1 complex locus protein and similar proteins; PRDM3 (also termed MDS1 and EVI1 complex locus protein, ecotropic virus integration site 1 protein, EVI-1, myelodysplasia syndrome 1 protein, myelodysplasia syndrome-associated protein 1, or MECOM) is a nuclear transcription factor, which is essential for the proliferation/maintenance of hematopoietic stem cells (HSCs). It is closely related to paralog PRDM16, both o fwhich are directly linked to various aspects of oncogenic transformation.


Pssm-ID: 380991  Cd Length: 158  Bit Score: 70.74  E-value: 3.71e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530399650 389 PEHGPVTFVPDTPIesrarlslPKQLVLRQS-IVGAEVvgvlpltGVWTGETIPVRTCFGPLIGQQSHSMevaewtdKAV 467
Cdd:cd19214   17 PYKAPIYIPDDIPI--------PSEFELRESnIPGTGL-------GIWTKRKIEVGEKFGPYVGEQRSNL-------KDP 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530399650 468 NHIWKIYHN-GVLEFCIITTDENECNWMMFVRKARNREEQNLVAYPHDGKIFFCTSQDIPPENELL-FYYSRDYAQQIGV 545
Cdd:cd19214   75 SYGWEVLDEfGNVKFCIDASQPDVGSWLKYIRFAGCYDQHNLVACQINDQIFYRAVADIDPGEELLlFMKSEDYSHETMA 154


                 ..
gi 530399650 546 PE 547
Cdd:cd19214  155 PD 156
PR-SET_ZFPM cd19201
PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins; ZFPM1 (also ...
 408-532 3.86e-14

PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins; ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380978  Cd Length: 122  Bit Score: 69.68  E-value: 3.86e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530399650 408 LSLPKQLVLRQSIVGAEVVGvlpltGVWTGETIPVRTCFGPL---IGQQSHSMEVaEWTDKAVNhiwkiyhnGVLEFCII 484
Cdd:cd19201    1 LSLPGELELRKPSQDAGRSG-----GVWAKQPLPEGTRFGPYpgkLVKEPLDPSY-EWKVEAQG--------SKGGEGLL 66

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 530399650 485 TTDENECNWMMFVRKARNREEQNLVAYPHDGKIFFCTSQDIPPENELL 532
Cdd:cd19201   67 LLTEDSGTWLKLVRSADDEDEANLILYFKGGQIWCEVTKDIPPGEELI 114
PR-SET_PRDM11 cd19195
PR-SET domain found in PR domain zinc finger protein 11 (PRDM11) and similar proteins; PRDM11 ...
 438-543 1.62e-11

PR-SET domain found in PR domain zinc finger protein 11 (PRDM11) and similar proteins; PRDM11 (also termed PR domain-containing protein 11) may be involved in transcription regulation.


Pssm-ID: 380972  Cd Length: 127  Bit Score: 62.18  E-value: 1.62e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530399650 438 ETIPVRTCFGPLIGQQSHSmevaewtDKAVNHI-WKIYHNGVLEFCIITTDENECNWMMFVRKARNREEQNLVAYPHDGK 516
Cdd:cd19195   26 EVIPKGHIFGPYEGQICTQ-------DKSSGFFsWLIVDKNNRYKSIDGSDETKANWMRYVVISREEREQNLLAFQHSEQ 98

                         90       100
                 ....*....|....*....|....*..
gi 530399650 517 IFFCTSQDIPPENELLFYYSRDYAQQI 543
Cdd:cd19195   99 IYFRACRDIRPGEKLRVWYSEDYMKRL 125
PR-SET_PRDM13 cd19197
PR-SET domain found in PR domain zinc finger protein 13 (PRDM13) and similar proteins; PRDM13 ...
 475-543 1.04e-09

PR-SET domain found in PR domain zinc finger protein 13 (PRDM13) and similar proteins; PRDM13 (also termed PR domain-containing protein 13) may be involved in transcriptional regulation. It mediates the balance of inhibitory and excitatory neurons in somatosensory circuits.


Pssm-ID: 380974  Cd Length: 103  Bit Score: 56.37  E-value: 1.04e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 530399650 475 HNGVLEFCIITTDENECNWMMFVRKARNREEQNLVAY--PHDGKIFFCTSQDIPPENELLFYYSRDYAQQI 543
Cdd:cd19197   33 RRVRGDYLVDESGSPATEWIGLVRAARNNQEQNLEAIadLPGGQIFYRALRDIQPGEELTVWYSNSLAQWF 103
PR-SET_PRDM16 cd19213
PR-SET domain found in PR domain zinc finger protein 16 (PRDM16) and similar proteins; PRDM16, ...
 389-534 1.24e-09

PR-SET domain found in PR domain zinc finger protein 16 (PRDM16) and similar proteins; PRDM16, also termed PR domain-containing protein 16, or transcription factor MEL1, or MDS1/EVI1-like gene 1, functions as a transcriptional regulator. PRDM16 is preferentially expressed by hematopoietic and neuronal stem cells and is closely related to paralog of PRDM3, both of which are directly linked to various aspects of oncogenic transformation.


Pssm-ID: 380990  Cd Length: 162  Bit Score: 57.96  E-value: 1.24e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530399650 389 PEHGPVTFVPDTPIesrarlslPKQLVLRQS-IVGAEVvgvlpltGVWTGETIPVRTCFGPLIGQQsHSmevaewTDKAV 467
Cdd:cd19213    7 PYEAPVYIPDDIPI--------PSDFELRESsIPGAGL-------GVWAKRKIEAGERFGPYTGVQ-RS------TLKDT 64

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530399650 468 NHIWKIYHN------------------GVLEFCIITTDENECNWMMFVRKARNREEQNLVAYPHDGKIFFCTSQDIPPEN 529
Cdd:cd19213   65 NFGWEQILNdvevssqegcitkivddlGNEKFCVDAGQAGAGSWLKYIRVACSCDEQNLTACQINEQIYYKVIKDIEPGE 144


                 ....*
gi 530399650 530 ELLFY 534
Cdd:cd19213  145 ELLVY 149
PR-SET_PRDM5 cd19190
PR-SET domain found in PR domain zinc finger protein 5 (PRDM5) and similar proteins; PRDM5 ...
 433-535 1.44e-08

PR-SET domain found in PR domain zinc finger protein 5 (PRDM5) and similar proteins; PRDM5 (also termed PR domain-containing protein 5) is a sequence-specific DNA-binding transcription factor that represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1.


Pssm-ID: 380967  Cd Length: 127  Bit Score: 53.84  E-value: 1.44e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530399650 433 GVWTGETIPVRTCFGPLIGQQSHSMEVAEWTDKAVnhIWKIYHN-GVLEFCIITTDENECNWMMFVRKARNREEQNLVAY 511
Cdd:cd19190   21 GLYTARRVKKGEKFGPFAGEKRMPNELDESMDPRL--MWEVRGSkGEVLYILDASNPRHSNWLRFVHEAPSQEQKNLAAI 98

                         90       100
                 ....*....|....*....|....
gi 530399650 512 PHDGKIFFCTSQDIPPENELLFYY 535
Cdd:cd19190   99 QEGENIFYLAVDDIETDTELLIGY 122
zf-H2C2_2 pfam13465
Zinc-finger double domain;
639-664 8.65e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 42.74  E-value: 8.65e-06
                          10        20
                  ....*....|....*....|....*.
gi 530399650  639 NLRTHLKIHTGQKNYRCTLCDKSFTQ 664
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
PR-SET_PRDM17 cd10520
PR-SET domain found in PR domain zinc finger protein 17 (PRDM17) and similar proteins; PRDM17 ...
 433-532 2.52e-05

PR-SET domain found in PR domain zinc finger protein 17 (PRDM17) and similar proteins; PRDM17 (also termed zinc finger protein 408 (ZNF408)) may be involved in transcriptional regulation.


Pssm-ID: 380918  Cd Length: 121  Bit Score: 44.33  E-value: 2.52e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530399650 433 GVW-TGETIPVRTCFGPLIGQqshsmevAEWTDKAVNHIWKIYHNGVLEFCIITtdENECNWMMFVRKARNREEQNLVAY 511
Cdd:cd10520   22 GVWcVGDALQKGTFLGPLEEE-------LESHDLTEGGSPRQEESGQSGDVLAC--EQSSKWMRFACRARSEEESNVAVV 92

                         90       100
                 ....*....|....*....|.
gi 530399650 512 PHDGKIFFCTSQDIPPENELL 532
Cdd:cd10520   93 RLSGRLHLRVCKDIEPGSELL 113
zf-H2C2_2 pfam13465
Zinc-finger double domain;
667-690 3.29e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 3.29e-04
                          10        20
                  ....*....|....*....|....
gi 530399650  667 HLESHMVIHTGEKNLKCDYCDKLF 690
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 653-675 5.96e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.66  E-value: 5.96e-04
                          10        20
                  ....*....|....*....|...
gi 530399650  653 YRCTLCDKSFTQKAHLESHMVIH 675
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 433-540 9.15e-04

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 40.01  E-value: 9.15e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530399650   433 GVWTGETIPVRTCFGPLIG-----QQSHSMEVAEWTDKAVNH-IWKIYhngvLEFCIITTDENecNWMMFVRKARNREEQ 506
Cdd:smart00317  14 GVRATEDIPKGEFIGEYVGeiitsEEAEERPKAYDTDGAKAFyLFDID----SDLCIDARRKG--NLARFINHSCEPNCE 87

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 530399650   507 NL-VAYPHDGKIFFCTSQDIPPENELLFYYSRDYA 540
Cdd:smart00317  88 LLfVEVNGDDRIVIFALRDIKPGEELTIDYGSDYA 122
zf-H2C2_2 pfam13465
Zinc-finger double domain;
695-720 3.14e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 3.14e-03
                          10        20
                  ....*....|....*....|....*.
gi 530399650  695 DLKQHVLIHTQERQIKCPKCDKLFLR 720
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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