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Conserved domains on  [gi|530372137|ref|XP_005265043|]
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raftlin isoform X2 [Homo sapiens]

Protein Classification

Raftlin domain-containing protein( domain architecture ID 10633677)

Raftlin domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Raftlin pfam15250
Raftlin; This family of proteins plays a role in the formation and/or maintenance of lipid ...
1-471 0e+00

Raftlin; This family of proteins plays a role in the formation and/or maintenance of lipid rafts.


:

Pssm-ID: 464590  Cd Length: 456  Bit Score: 899.09  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372137    1 MGCGLNKLEKRDEKRPGNIYSTLKRPQVETKIDVSYEYRFLEFTTLSAAELPGSSAVRLASLRDLPAQLLELYQQGFSLA 80
Cdd:pfam15250   1 MGCGLNKLEKPDEKRPGNIYSTLKRPQVETKIDVAYEYRFLDFTTLSAAELPRSSAIRLSSLRDLPAQLEELYQQGFVLA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372137   81 ALHPFVQPTHEREKTPLEHIFRAILIKKTDRSQKTDLHNEGYILELDCCSSLDHPTDQKLIPEFIKKIQEAASQGLKFVG 160
Cdd:pfam15250  81 ALHPFVQPTGEREKTPAEHIFRAVLIKKTERSQKADSHQRGYRLEIEECSSLDHLQDQKIIPELIKKIQEAASRGLKFVG 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372137  161 VIPQYHSSVNSAGSSAPVSTANSTEDARDAKNARG---DHASLENEKPGTGDVCSAPAGRNQSPEPSSGPRGEVPLAKQP 237
Cdd:pfam15250 161 VIPQYHSPPNSCNGSPLTPGDNESAEARDEKNARGgseDHCSLENERPGALSGQSSEAGTEEEPHPEEGPGGEGPAAEQP 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372137  238 SSPSGEGDGGELSPQGvsktldgpesnplevheepLSGKMEIFTLFNKPKSHQKCRQYYPVTIPLHVSKNGQTVSGLDAN 317
Cdd:pfam15250 241 QLPSGEGDGSESPSKG-------------------EDGKMEIFALFNKPKSDQKCRQYYEVTIPMRVSRNGQTVSSLDAN 301
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372137  318 WLEHMSDHFRKGGMLVNAVFYLGIVNDSLHGLTDGVFIFEAVSTEDSKTIQGYDAIVVEQWTVLEGVEVQTDYVPLLNSL 397
Cdd:pfam15250 302 WLEHMTDHFRKGGSLVNAFFCLGTVNDSLPGLLDGVFIFEEESSEDSKSIQGYDAIVVEQWTVLEGVEVQTDYGPLLNSL 381
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 530372137  398 AAYGWQLTCVLPTPVVKTTSEGSVSTKQIVFLQRPCLPQKIKKKESKFQWRFSREEMHNRQMRKS-KGKLSARDK 471
Cdd:pfam15250 382 AEYGWQLTCVLPTPIVRTDREGNLATKQVVFLQRPCLPQKAKKKESKFQWRFSREEMRNRQGRKSiKGKLSAREK 456
 
Name Accession Description Interval E-value
Raftlin pfam15250
Raftlin; This family of proteins plays a role in the formation and/or maintenance of lipid ...
1-471 0e+00

Raftlin; This family of proteins plays a role in the formation and/or maintenance of lipid rafts.


Pssm-ID: 464590  Cd Length: 456  Bit Score: 899.09  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372137    1 MGCGLNKLEKRDEKRPGNIYSTLKRPQVETKIDVSYEYRFLEFTTLSAAELPGSSAVRLASLRDLPAQLLELYQQGFSLA 80
Cdd:pfam15250   1 MGCGLNKLEKPDEKRPGNIYSTLKRPQVETKIDVAYEYRFLDFTTLSAAELPRSSAIRLSSLRDLPAQLEELYQQGFVLA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372137   81 ALHPFVQPTHEREKTPLEHIFRAILIKKTDRSQKTDLHNEGYILELDCCSSLDHPTDQKLIPEFIKKIQEAASQGLKFVG 160
Cdd:pfam15250  81 ALHPFVQPTGEREKTPAEHIFRAVLIKKTERSQKADSHQRGYRLEIEECSSLDHLQDQKIIPELIKKIQEAASRGLKFVG 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372137  161 VIPQYHSSVNSAGSSAPVSTANSTEDARDAKNARG---DHASLENEKPGTGDVCSAPAGRNQSPEPSSGPRGEVPLAKQP 237
Cdd:pfam15250 161 VIPQYHSPPNSCNGSPLTPGDNESAEARDEKNARGgseDHCSLENERPGALSGQSSEAGTEEEPHPEEGPGGEGPAAEQP 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372137  238 SSPSGEGDGGELSPQGvsktldgpesnplevheepLSGKMEIFTLFNKPKSHQKCRQYYPVTIPLHVSKNGQTVSGLDAN 317
Cdd:pfam15250 241 QLPSGEGDGSESPSKG-------------------EDGKMEIFALFNKPKSDQKCRQYYEVTIPMRVSRNGQTVSSLDAN 301
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372137  318 WLEHMSDHFRKGGMLVNAVFYLGIVNDSLHGLTDGVFIFEAVSTEDSKTIQGYDAIVVEQWTVLEGVEVQTDYVPLLNSL 397
Cdd:pfam15250 302 WLEHMTDHFRKGGSLVNAFFCLGTVNDSLPGLLDGVFIFEEESSEDSKSIQGYDAIVVEQWTVLEGVEVQTDYGPLLNSL 381
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 530372137  398 AAYGWQLTCVLPTPVVKTTSEGSVSTKQIVFLQRPCLPQKIKKKESKFQWRFSREEMHNRQMRKS-KGKLSARDK 471
Cdd:pfam15250 382 AEYGWQLTCVLPTPIVRTDREGNLATKQVVFLQRPCLPQKAKKKESKFQWRFSREEMRNRQGRKSiKGKLSAREK 456
 
Name Accession Description Interval E-value
Raftlin pfam15250
Raftlin; This family of proteins plays a role in the formation and/or maintenance of lipid ...
1-471 0e+00

Raftlin; This family of proteins plays a role in the formation and/or maintenance of lipid rafts.


Pssm-ID: 464590  Cd Length: 456  Bit Score: 899.09  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372137    1 MGCGLNKLEKRDEKRPGNIYSTLKRPQVETKIDVSYEYRFLEFTTLSAAELPGSSAVRLASLRDLPAQLLELYQQGFSLA 80
Cdd:pfam15250   1 MGCGLNKLEKPDEKRPGNIYSTLKRPQVETKIDVAYEYRFLDFTTLSAAELPRSSAIRLSSLRDLPAQLEELYQQGFVLA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372137   81 ALHPFVQPTHEREKTPLEHIFRAILIKKTDRSQKTDLHNEGYILELDCCSSLDHPTDQKLIPEFIKKIQEAASQGLKFVG 160
Cdd:pfam15250  81 ALHPFVQPTGEREKTPAEHIFRAVLIKKTERSQKADSHQRGYRLEIEECSSLDHLQDQKIIPELIKKIQEAASRGLKFVG 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372137  161 VIPQYHSSVNSAGSSAPVSTANSTEDARDAKNARG---DHASLENEKPGTGDVCSAPAGRNQSPEPSSGPRGEVPLAKQP 237
Cdd:pfam15250 161 VIPQYHSPPNSCNGSPLTPGDNESAEARDEKNARGgseDHCSLENERPGALSGQSSEAGTEEEPHPEEGPGGEGPAAEQP 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372137  238 SSPSGEGDGGELSPQGvsktldgpesnplevheepLSGKMEIFTLFNKPKSHQKCRQYYPVTIPLHVSKNGQTVSGLDAN 317
Cdd:pfam15250 241 QLPSGEGDGSESPSKG-------------------EDGKMEIFALFNKPKSDQKCRQYYEVTIPMRVSRNGQTVSSLDAN 301
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372137  318 WLEHMSDHFRKGGMLVNAVFYLGIVNDSLHGLTDGVFIFEAVSTEDSKTIQGYDAIVVEQWTVLEGVEVQTDYVPLLNSL 397
Cdd:pfam15250 302 WLEHMTDHFRKGGSLVNAFFCLGTVNDSLPGLLDGVFIFEEESSEDSKSIQGYDAIVVEQWTVLEGVEVQTDYGPLLNSL 381
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 530372137  398 AAYGWQLTCVLPTPVVKTTSEGSVSTKQIVFLQRPCLPQKIKKKESKFQWRFSREEMHNRQMRKS-KGKLSARDK 471
Cdd:pfam15250 382 AEYGWQLTCVLPTPIVRTDREGNLATKQVVFLQRPCLPQKAKKKESKFQWRFSREEMRNRQGRKSiKGKLSAREK 456
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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