charged multivesicular body protein 6 isoform X1 [Homo sapiens]
Protein Classification
SNF7 family protein( domain architecture ID 10505749)
SNF7 family protein may be involved in protein sorting and transport from the endosome to the vacuole/lysosome
List of domain hits
| Name | Accession | Description | Interval | E-value | ||||
| Snf7 | pfam03357 | Snf7; This family of proteins are involved in protein sorting and transport from the endosome ... |
18-177 | 9.11e-45 | ||||
Snf7; This family of proteins are involved in protein sorting and transport from the endosome to the vacuole/lysosome in eukaryotic cells. Vacuoles/lysosomes play an important role in the degradation of both lipids and cellular proteins. In order to perform this degradative function, vacuoles/lysosomes contain numerous hydrolases which have been transported in the form of inactive precursors via the biosynthetic pathway and are proteolytically activated upon delivery to the vacuole/lysosome. The delivery of transmembrane proteins, such as activated cell surface receptors to the lumen of the vacuole/lysosome, either for degradation/downregulation, or in the case of hydrolases, for proper localization, requires the formation of multivesicular bodies (MVBs). These late endosomal structures are formed by invaginating and budding of the limiting membrane into the lumen of the compartment. During this process, a subset of the endosomal membrane proteins is sorted into the forming vesicles. Mature MVBs fuse with the vacuole/lysosome, thereby releasing cargo containing vesicles into its hydrolytic lumen for degradation. Endosomal proteins that are not sorted into the intralumenal MVB vesicles are either recycled back to the plasma membrane or Golgi complex, or remain in the limiting membrane of the MVB and are thereby transported to the limiting membrane of the vacuole/lysosome as a consequence of fusion. Therefore, the MVB sorting pathway plays a critical role in the decision between recycling and degradation of membrane proteins. A few archaeal sequences are also present within this family. : Pssm-ID: 460896 [Multi-domain] Cd Length: 168 Bit Score: 147.77 E-value: 9.11e-45
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| Name | Accession | Description | Interval | E-value | ||||
| Snf7 | pfam03357 | Snf7; This family of proteins are involved in protein sorting and transport from the endosome ... |
18-177 | 9.11e-45 | ||||
Snf7; This family of proteins are involved in protein sorting and transport from the endosome to the vacuole/lysosome in eukaryotic cells. Vacuoles/lysosomes play an important role in the degradation of both lipids and cellular proteins. In order to perform this degradative function, vacuoles/lysosomes contain numerous hydrolases which have been transported in the form of inactive precursors via the biosynthetic pathway and are proteolytically activated upon delivery to the vacuole/lysosome. The delivery of transmembrane proteins, such as activated cell surface receptors to the lumen of the vacuole/lysosome, either for degradation/downregulation, or in the case of hydrolases, for proper localization, requires the formation of multivesicular bodies (MVBs). These late endosomal structures are formed by invaginating and budding of the limiting membrane into the lumen of the compartment. During this process, a subset of the endosomal membrane proteins is sorted into the forming vesicles. Mature MVBs fuse with the vacuole/lysosome, thereby releasing cargo containing vesicles into its hydrolytic lumen for degradation. Endosomal proteins that are not sorted into the intralumenal MVB vesicles are either recycled back to the plasma membrane or Golgi complex, or remain in the limiting membrane of the MVB and are thereby transported to the limiting membrane of the vacuole/lysosome as a consequence of fusion. Therefore, the MVB sorting pathway plays a critical role in the decision between recycling and degradation of membrane proteins. A few archaeal sequences are also present within this family. Pssm-ID: 460896 [Multi-domain] Cd Length: 168 Bit Score: 147.77 E-value: 9.11e-45
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| PTZ00446 | PTZ00446 | vacuolar sorting protein SNF7-like; Provisional |
9-169 | 4.67e-09 | ||||
vacuolar sorting protein SNF7-like; Provisional Pssm-ID: 240422 [Multi-domain] Cd Length: 191 Bit Score: 54.35 E-value: 4.67e-09
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| Smc | COG1196 | Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
13-170 | 1.18e-03 | ||||
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 39.92 E-value: 1.18e-03
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| Name | Accession | Description | Interval | E-value | ||||
| Snf7 | pfam03357 | Snf7; This family of proteins are involved in protein sorting and transport from the endosome ... |
18-177 | 9.11e-45 | ||||
Snf7; This family of proteins are involved in protein sorting and transport from the endosome to the vacuole/lysosome in eukaryotic cells. Vacuoles/lysosomes play an important role in the degradation of both lipids and cellular proteins. In order to perform this degradative function, vacuoles/lysosomes contain numerous hydrolases which have been transported in the form of inactive precursors via the biosynthetic pathway and are proteolytically activated upon delivery to the vacuole/lysosome. The delivery of transmembrane proteins, such as activated cell surface receptors to the lumen of the vacuole/lysosome, either for degradation/downregulation, or in the case of hydrolases, for proper localization, requires the formation of multivesicular bodies (MVBs). These late endosomal structures are formed by invaginating and budding of the limiting membrane into the lumen of the compartment. During this process, a subset of the endosomal membrane proteins is sorted into the forming vesicles. Mature MVBs fuse with the vacuole/lysosome, thereby releasing cargo containing vesicles into its hydrolytic lumen for degradation. Endosomal proteins that are not sorted into the intralumenal MVB vesicles are either recycled back to the plasma membrane or Golgi complex, or remain in the limiting membrane of the MVB and are thereby transported to the limiting membrane of the vacuole/lysosome as a consequence of fusion. Therefore, the MVB sorting pathway plays a critical role in the decision between recycling and degradation of membrane proteins. A few archaeal sequences are also present within this family. Pssm-ID: 460896 [Multi-domain] Cd Length: 168 Bit Score: 147.77 E-value: 9.11e-45
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| PTZ00446 | PTZ00446 | vacuolar sorting protein SNF7-like; Provisional |
9-169 | 4.67e-09 | ||||
vacuolar sorting protein SNF7-like; Provisional Pssm-ID: 240422 [Multi-domain] Cd Length: 191 Bit Score: 54.35 E-value: 4.67e-09
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| PTZ00464 | PTZ00464 | SNF-7-like protein; Provisional |
1-175 | 2.49e-06 | ||||
SNF-7-like protein; Provisional Pssm-ID: 240425 [Multi-domain] Cd Length: 211 Bit Score: 46.73 E-value: 2.49e-06
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| CCDC158 | pfam15921 | Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ... |
12-167 | 4.65e-04 | ||||
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known. Pssm-ID: 464943 [Multi-domain] Cd Length: 1112 Bit Score: 41.26 E-value: 4.65e-04
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| Smc | COG1196 | Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
13-170 | 1.18e-03 | ||||
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 39.92 E-value: 1.18e-03
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| CwlO1 | COG3883 | Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ... |
11-92 | 2.24e-03 | ||||
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown]; Pssm-ID: 443091 [Multi-domain] Cd Length: 379 Bit Score: 38.66 E-value: 2.24e-03
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| Blast search parameters | ||||
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