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Conserved domains on  [gi|530389990|ref|XP_005251560|]
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WD40 repeat-containing protein SMU1 isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
41-462 4.32e-71

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 230.57  E-value: 4.32e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530389990  41 VDSIESFVADINSGHWDTVLQAIQSLKLPDKTLIDLYEQAYPDGSSKEKRRAAIAQALAGEVSVVPPSRLMALLGQALKW 120
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530389990 121 QQHQGLLPPGMTIDLFRGKAAVK--DVEEEKFPTQLSRHikfgqKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIR 198
Cdd:COG2319   81 VLSVAFSPDGRLLASASADGTVRlwDLATGLLLRTLTGH-----TGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLL 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530389990 199 KDLKYQaqdnfmmmDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFeRAHSKGVTCLSFSKDSSQILSASFDQ 278
Cdd:COG2319  156 RTLTGH--------SGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL-TGHTGAVRSVAFSPDGKLLASGSADG 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530389990 279 TIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKslgstaGTDITVNSVILLPkN 358
Cdd:COG2319  227 TVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLT------GHSGGVNSVAFSP-D 299

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530389990 359 PEHFVVCNRSNTVVIMNMQ-GQIVRSFSSgkrEGGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVI 437
Cdd:COG2319  300 GKLLASGSDDGTVRLWDLAtGKLLRTLTG---HTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVT 376

                        410       420
                 ....*....|....*....|....*
gi 530389990 438 GIAHHPHQNLIATYSEDGLLKLWKP 462
Cdd:COG2319  377 SVAFSPDGRTLASGSADGTVRLWDL 401
LisH_TPL pfam17814
LisH-like dimerization domain; TOPLESS (TPL) proteins have a highly conserved N-terminal ...
 7-36 3.59e-11

LisH-like dimerization domain; TOPLESS (TPL) proteins have a highly conserved N-terminal domain containing a lissencephaly homologous (LisH) dimerization motif.


:

Pssm-ID: 375350  Cd Length: 30  Bit Score: 57.40  E-value: 3.59e-11
                          10        20        30
                  ....*....|....*....|....*....|
gi 530389990    7 SSDVIRLIMQYLKENSLHRALATLQEETTV 36
Cdd:pfam17814   1 SQDVVRLILQFLKENGLHRTLQALQTESGV 30
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
41-462 4.32e-71

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 230.57  E-value: 4.32e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530389990  41 VDSIESFVADINSGHWDTVLQAIQSLKLPDKTLIDLYEQAYPDGSSKEKRRAAIAQALAGEVSVVPPSRLMALLGQALKW 120
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530389990 121 QQHQGLLPPGMTIDLFRGKAAVK--DVEEEKFPTQLSRHikfgqKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIR 198
Cdd:COG2319   81 VLSVAFSPDGRLLASASADGTVRlwDLATGLLLRTLTGH-----TGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLL 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530389990 199 KDLKYQaqdnfmmmDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFeRAHSKGVTCLSFSKDSSQILSASFDQ 278
Cdd:COG2319  156 RTLTGH--------SGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL-TGHTGAVRSVAFSPDGKLLASGSADG 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530389990 279 TIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKslgstaGTDITVNSVILLPkN 358
Cdd:COG2319  227 TVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLT------GHSGGVNSVAFSP-D 299

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530389990 359 PEHFVVCNRSNTVVIMNMQ-GQIVRSFSSgkrEGGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVI 437
Cdd:COG2319  300 GKLLASGSDDGTVRLWDLAtGKLLRTLTG---HTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVT 376

                        410       420
                 ....*....|....*....|....*
gi 530389990 438 GIAHHPHQNLIATYSEDGLLKLWKP 462
Cdd:COG2319  377 SVAFSPDGRTLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 154-461 4.01e-63

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 206.03  E-value: 4.01e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530389990 154 LSRHIKfGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAqdnfmmmdDAVLCMCFSRDTEMLATGAQ 233
Cdd:cd00200    1 LRRTLK-GHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHT--------GPVRDVAASADGTYLASGSS 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530389990 234 DGKIKVWKIQSGQCLRRFErAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYI 313
Cdd:cd00200   72 DKTIRLWDLETGECVRTLT-GHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFV 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530389990 314 ISASSDGTVKIWNMKTTECSNTFKslgstaGTDITVNSVILLPKNpEHFVVCNRSNTVVIMNMQ-GQIVRSFsSGKREGg 392
Cdd:cd00200  151 ASSSQDGTIKLWDLRTGKCVATLT------GHTGEVNSVAFSPDG-EKLLSSSSDGTIKLWDLStGKCLGTL-RGHENG- 221

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 530389990 393 dFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLLKLWK 461
Cdd:cd00200  222 -VNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
LisH_TPL pfam17814
LisH-like dimerization domain; TOPLESS (TPL) proteins have a highly conserved N-terminal ...
 7-36 3.59e-11

LisH-like dimerization domain; TOPLESS (TPL) proteins have a highly conserved N-terminal domain containing a lissencephaly homologous (LisH) dimerization motif.


Pssm-ID: 375350  Cd Length: 30  Bit Score: 57.40  E-value: 3.59e-11
                          10        20        30
                  ....*....|....*....|....*....|
gi 530389990    7 SSDVIRLIMQYLKENSLHRALATLQEETTV 36
Cdd:pfam17814   1 SQDVVRLILQFLKENGLHRTLQALQTESGV 30
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 287-326 5.09e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.54  E-value: 5.09e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 530389990   287 SGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWN 326
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 133-330 5.90e-09

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 58.56  E-value: 5.90e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530389990 133 IDLFRGKAAVKDVEEEKFPT-QLSRHIKFGQ-------KSHVECARFspdgqylvtgsvDGFIEVWNFTTGKIRKDLKyQ 204
Cdd:PLN00181 507 IKIFECESIIKDGRDIHYPVvELASRSKLSGicwnsyiKSQVASSNF------------EGVVQVWDVARSQLVTEMK-E 573

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530389990 205 AQDNFMMMDDAvlcmcfSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERahSKGVTCLSFSKDSSQILS-ASFDQTIRIH 283
Cdd:PLN00181 574 HEKRVWSIDYS------SADPTLLASGSDDGSVKLWSINQGVSIGTIKT--KANICCVQFPSESGRSLAfGSADHKVYYY 645

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 530389990 284 GLKSGKT-LKEFRGHSSFVNEATFTqDGHYIISASSDGTVKIWNMKTT 330
Cdd:PLN00181 646 DLRNPKLpLCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWDLSMS 692
WD40 pfam00400
WD domain, G-beta repeat;
288-326 2.12e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 50.04  E-value: 2.12e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 530389990  288 GKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWN 326
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
LisH smart00667
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ...
 5-38 9.95e-07

Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.


Pssm-ID: 128913  Cd Length: 34  Bit Score: 45.12  E-value: 9.95e-07
                           10        20        30
                   ....*....|....*....|....*....|....
gi 530389990     5 IESSDVIRLIMQYLKENSLHRALATLQEETTVSL 38
Cdd:smart00667   1 ISRSELNRLILEYLLRNGYEETAETLQKESGLSL 34
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
41-462 4.32e-71

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 230.57  E-value: 4.32e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530389990  41 VDSIESFVADINSGHWDTVLQAIQSLKLPDKTLIDLYEQAYPDGSSKEKRRAAIAQALAGEVSVVPPSRLMALLGQALKW 120
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530389990 121 QQHQGLLPPGMTIDLFRGKAAVK--DVEEEKFPTQLSRHikfgqKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIR 198
Cdd:COG2319   81 VLSVAFSPDGRLLASASADGTVRlwDLATGLLLRTLTGH-----TGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLL 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530389990 199 KDLKYQaqdnfmmmDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFeRAHSKGVTCLSFSKDSSQILSASFDQ 278
Cdd:COG2319  156 RTLTGH--------SGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL-TGHTGAVRSVAFSPDGKLLASGSADG 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530389990 279 TIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKslgstaGTDITVNSVILLPkN 358
Cdd:COG2319  227 TVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLT------GHSGGVNSVAFSP-D 299

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530389990 359 PEHFVVCNRSNTVVIMNMQ-GQIVRSFSSgkrEGGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVI 437
Cdd:COG2319  300 GKLLASGSDDGTVRLWDLAtGKLLRTLTG---HTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVT 376

                        410       420
                 ....*....|....*....|....*
gi 530389990 438 GIAHHPHQNLIATYSEDGLLKLWKP 462
Cdd:COG2319  377 SVAFSPDGRTLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 154-461 4.01e-63

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 206.03  E-value: 4.01e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530389990 154 LSRHIKfGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAqdnfmmmdDAVLCMCFSRDTEMLATGAQ 233
Cdd:cd00200    1 LRRTLK-GHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHT--------GPVRDVAASADGTYLASGSS 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530389990 234 DGKIKVWKIQSGQCLRRFErAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYI 313
Cdd:cd00200   72 DKTIRLWDLETGECVRTLT-GHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFV 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530389990 314 ISASSDGTVKIWNMKTTECSNTFKslgstaGTDITVNSVILLPKNpEHFVVCNRSNTVVIMNMQ-GQIVRSFsSGKREGg 392
Cdd:cd00200  151 ASSSQDGTIKLWDLRTGKCVATLT------GHTGEVNSVAFSPDG-EKLLSSSSDGTIKLWDLStGKCLGTL-RGHENG- 221

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 530389990 393 dFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLLKLWK 461
Cdd:cd00200  222 -VNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
144-329 2.54e-49

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 173.56  E-value: 2.54e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530389990 144 DVEEEKFPTQLSRHikfgqKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQaqdnfmmmDDAVLCMCFSR 223
Cdd:COG2319  232 DLATGKLLRTLTGH-----SGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGH--------SGGVNSVAFSP 298

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530389990 224 DTEMLATGAQDGKIKVWKIQSGQCLRRFErAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNE 303
Cdd:COG2319  299 DGKLLASGSDDGTVRLWDLATGKLLRTLT-GHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTS 377

                        170       180
                 ....*....|....*....|....*.
gi 530389990 304 ATFTQDGHYIISASSDGTVKIWNMKT 329
Cdd:COG2319  378 VAFSPDGRTLASGSADGTVRLWDLAT 403
LisH_TPL pfam17814
LisH-like dimerization domain; TOPLESS (TPL) proteins have a highly conserved N-terminal ...
 7-36 3.59e-11

LisH-like dimerization domain; TOPLESS (TPL) proteins have a highly conserved N-terminal domain containing a lissencephaly homologous (LisH) dimerization motif.


Pssm-ID: 375350  Cd Length: 30  Bit Score: 57.40  E-value: 3.59e-11
                          10        20        30
                  ....*....|....*....|....*....|
gi 530389990    7 SSDVIRLIMQYLKENSLHRALATLQEETTV 36
Cdd:pfam17814   1 SQDVVRLILQFLKENGLHRTLQALQTESGV 30
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 287-326 5.09e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.54  E-value: 5.09e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 530389990   287 SGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWN 326
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 133-330 5.90e-09

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 58.56  E-value: 5.90e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530389990 133 IDLFRGKAAVKDVEEEKFPT-QLSRHIKFGQ-------KSHVECARFspdgqylvtgsvDGFIEVWNFTTGKIRKDLKyQ 204
Cdd:PLN00181 507 IKIFECESIIKDGRDIHYPVvELASRSKLSGicwnsyiKSQVASSNF------------EGVVQVWDVARSQLVTEMK-E 573

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530389990 205 AQDNFMMMDDAvlcmcfSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERahSKGVTCLSFSKDSSQILS-ASFDQTIRIH 283
Cdd:PLN00181 574 HEKRVWSIDYS------SADPTLLASGSDDGSVKLWSINQGVSIGTIKT--KANICCVQFPSESGRSLAfGSADHKVYYY 645

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 530389990 284 GLKSGKT-LKEFRGHSSFVNEATFTqDGHYIISASSDGTVKIWNMKTT 330
Cdd:PLN00181 646 DLRNPKLpLCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWDLSMS 692
WD40 pfam00400
WD domain, G-beta repeat;
288-326 2.12e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 50.04  E-value: 2.12e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 530389990  288 GKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWN 326
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 181-338 1.67e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 53.94  E-value: 1.67e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530389990 181 GSVDGFIE----VWNFTTGKIRKDLKyqaQDNFMMMDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSgqCLRRFERAHS 256
Cdd:PLN00181 450 GWIDPFLEglckYLSFSKLRVKADLK---QGDLLNSSNLVCAIGFDRDGEFFATAGVNKKIKIFECES--IIKDGRDIHY 524

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530389990 257 KGVTCLSFSKDS---------SQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQ-DGHYIISASSDGTVKIWN 326
Cdd:PLN00181 525 PVVELASRSKLSgicwnsyikSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWS 604

                        170
                 ....*....|..
gi 530389990 327 MKTTECSNTFKS 338
Cdd:PLN00181 605 INQGVSIGTIKT 616
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 244-283 9.70e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 9.70e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 530389990   244 SGQCLRRFeRAHSKGVTCLSFSKDSSQILSASFDQTIRIH 283
Cdd:smart00320   1 SGELLKTL-KGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
LisH smart00667
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ...
 5-38 9.95e-07

Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.


Pssm-ID: 128913  Cd Length: 34  Bit Score: 45.12  E-value: 9.95e-07
                           10        20        30
                   ....*....|....*....|....*....|....
gi 530389990     5 IESSDVIRLIMQYLKENSLHRALATLQEETTVSL 38
Cdd:smart00667   1 ISRSELNRLILEYLLRNGYEETAETLQKESGLSL 34
WD40 pfam00400
WD domain, G-beta repeat;
245-282 2.20e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.26  E-value: 2.20e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 530389990  245 GQCLRRFErAHSKGVTCLSFSKDSSQILSASFDQTIRI 282
Cdd:pfam00400   1 GKLLKTLE-GHTGSVTSLAFSPDGKLLASGSDDGTVKV 37
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 422-461 7.61e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 7.61e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 530389990   422 TGKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLLKLWK 461
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 161-191 2.43e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 2.43e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 530389990   161 GQKSHVECARFSPDGQYLVTGSVDGFIEVWN 191
Cdd:smart00320  10 GHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
161-191 5.24e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 5.24e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 530389990  161 GQKSHVECARFSPDGQYLVTGSVDGFIEVWN 191
Cdd:pfam00400   9 GHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 213-241 5.54e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 5.54e-05
                           10        20
                   ....*....|....*....|....*....
gi 530389990   213 DDAVLCMCFSRDTEMLATGAQDGKIKVWK 241
Cdd:smart00320  12 TGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
423-460 7.77e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 7.77e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 530389990  423 GKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLLKLW 460
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
213-240 2.31e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 2.31e-04
                          10        20
                  ....*....|....*....|....*...
gi 530389990  213 DDAVLCMCFSRDTEMLATGAQDGKIKVW 240
Cdd:pfam00400  11 TGSVTSLAFSPDGKLLASGSDDGTVKVW 38
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 213-267 8.45e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 38.41  E-value: 8.45e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 530389990  213 DDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFeRAHSKGVTCLSFSKD 267
Cdd:pfam12894  38 DLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHF-SAGSDLITCLGWGEN 91
PTZ00421 PTZ00421
coronin; Provisional
 158-299 1.45e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 41.03  E-value: 1.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530389990 158 IKFGQKSHVECARFSP-DGQYLVTGSVDGFIEVWNFTTgkirKDLKYQAQDNFMMM---DDAVLCMCFSRDTE-MLATGA 232
Cdd:PTZ00421  70 ILLGQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGIPE----EGLTQNISDPIVHLqghTKKVGIVSFHPSAMnVLASAG 145

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 530389990 233 QDGKIKVWKIQSGQCLRRFeRAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSS 299
Cdd:PTZ00421 146 ADMVVNVWDVERGKAVEVI-KCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHAS 211
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 163-331 2.89e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 39.67  E-value: 2.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530389990  163 KSHVECARFSPDGQYLVTGSVDGFIEVW-----NFTTGKIRKDLKYQAQDNFMMM----------DDAVLCMCFSRDTEM 227
Cdd:pfam20426 124 KDVVSCVAVTSDGSILATGSYDTTVMVWevlrgRSSEKRSRNTQTEFPRKDHVIAetpfhilcghDDIITCLYVSVELDI 203

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530389990  228 LATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLkSGKTLK--EFRGHssfVNEAT 305
Cdd:pfam20426 204 VISGSKDGTCIFHTLREGRYVRSIRHPSGCPLSKLVASRHGRIVLYADDDLSLHLYSI-NGKHIAssESNGR---LNCIE 279

                         170       180
                  ....*....|....*....|....*.
gi 530389990  306 FTQDGHYIISASSDGTVKIWNMKTTE 331
Cdd:pfam20426 280 LSSCGEFLVCAGDQGQIVVRSMNSLE 305
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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