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Conserved domains on  [gi|530386988|ref|XP_005250046|]
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WD repeat-containing protein 86 isoform X3 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 4-251 2.50e-57

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 189.47  E-value: 2.50e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530386988   4 GGSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQL--EDEAAFTCSADCTIRR 81
Cdd:cd00200   40 TGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFspDGRILSSSSRDKTIKV 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530386988  82 WDVLTGQCLQVYRGHTSIVN--RILVANNQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSAPwdlpstpcaee 159
Cdd:cd00200  120 WDVETGKCLTTLRGHTDWVNsvAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPD----------- 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530386988 160 aaaGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVI 239
Cdd:cd00200  189 ---GEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVT 265

                        250
                 ....*....|..
gi 530386988 240 CLECSRAAGTLA 251
Cdd:cd00200  266 SLAWSPDGKRLA 277
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 266-397 3.53e-05

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.08  E-value: 3.53e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530386988  266 SGATHSSSTASRCTARCSTPPRTTAPCASGTCAGSEVPRGPLRPCAASRGSSATrwAAPPRPCSRPDPAGPLQTPAQTPS 345
Cdd:PHA03247 2561 PAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPP--SPLPPDTHAPDPPPPSPSPAANEP 2638

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 530386988  346 GSQSAPPCYPRWWRPMAGEGRGARKPGREESPSQASGFSlVARRRWERECSP 397
Cdd:PHA03247 2639 DPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQAS-SPPQRPRRRAAR 2689
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 4-251 2.50e-57

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 189.47  E-value: 2.50e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530386988   4 GGSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQL--EDEAAFTCSADCTIRR 81
Cdd:cd00200   40 TGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFspDGRILSSSSRDKTIKV 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530386988  82 WDVLTGQCLQVYRGHTSIVN--RILVANNQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSAPwdlpstpcaee 159
Cdd:cd00200  120 WDVETGKCLTTLRGHTDWVNsvAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPD----------- 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530386988 160 aaaGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVI 239
Cdd:cd00200  189 ---GEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVT 265

                        250
                 ....*....|..
gi 530386988 240 CLECSRAAGTLA 251
Cdd:cd00200  266 SLAWSPDGKRLA 277
WD40 COG2319
WD40 repeat [General function prediction only];
4-253 6.29e-57

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 192.05  E-value: 6.29e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530386988   4 GGSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTfcqledEAAF--------TCSA 75
Cdd:COG2319  109 TGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVT------SVAFspdgkllaSGSD 182

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530386988  76 DCTIRRWDVLTGQCLQVYRGHTSIVNRILVA--NNQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSApwDlps 153
Cdd:COG2319  183 DGTVRLWDLATGKLLRTLTGHTGAVRSVAFSpdGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSP--D--- 257

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530386988 154 tpcaeeaaaGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFRE 233
Cdd:COG2319  258 ---------GRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTG 328

                        250       260
                 ....*....|....*....|
gi 530386988 234 HRGSVICLECSRAAGTLAPG 253
Cdd:COG2319  329 HTGAVRSVAFSPDGKTLASG 348
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 5-43 4.12e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.15  E-value: 4.12e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 530386988     5 GSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWS 43
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 108-222 8.81e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 51.24  E-value: 8.81e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530386988 108 NQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSapwdlpstpcaeeAAAGGLLVTGSTDGTAKVWQVASGCCHQ 187
Cdd:PLN00181 546 SQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYS-------------SADPTLLASGSDDGSVKLWSINQGVSIG 612

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 530386988 188 TLRghTGAVLCLVL---DTPGHTAFtGSTDATIRAWDI 222
Cdd:PLN00181 613 TIK--TKANICCVQfpsESGRSLAF-GSADHKVYYYDL 647
WD40 pfam00400
WD domain, G-beta repeat;
5-43 2.59e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.87  E-value: 2.59e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 530386988    5 GSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWS 43
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PHA03247 PHA03247
large tegument protein UL36; Provisional
 266-397 3.53e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.08  E-value: 3.53e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530386988  266 SGATHSSSTASRCTARCSTPPRTTAPCASGTCAGSEVPRGPLRPCAASRGSSATrwAAPPRPCSRPDPAGPLQTPAQTPS 345
Cdd:PHA03247 2561 PAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPP--SPLPPDTHAPDPPPPSPSPAANEP 2638

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 530386988  346 GSQSAPPCYPRWWRPMAGEGRGARKPGREESPSQASGFSlVARRRWERECSP 397
Cdd:PHA03247 2639 DPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQAS-SPPQRPRRRAAR 2689
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 4-251 2.50e-57

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 189.47  E-value: 2.50e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530386988   4 GGSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQL--EDEAAFTCSADCTIRR 81
Cdd:cd00200   40 TGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFspDGRILSSSSRDKTIKV 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530386988  82 WDVLTGQCLQVYRGHTSIVN--RILVANNQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSAPwdlpstpcaee 159
Cdd:cd00200  120 WDVETGKCLTTLRGHTDWVNsvAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPD----------- 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530386988 160 aaaGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVI 239
Cdd:cd00200  189 ---GEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVT 265

                        250
                 ....*....|..
gi 530386988 240 CLECSRAAGTLA 251
Cdd:cd00200  266 SLAWSPDGKRLA 277
WD40 COG2319
WD40 repeat [General function prediction only];
4-253 6.29e-57

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 192.05  E-value: 6.29e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530386988   4 GGSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTfcqledEAAF--------TCSA 75
Cdd:COG2319  109 TGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVT------SVAFspdgkllaSGSD 182

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530386988  76 DCTIRRWDVLTGQCLQVYRGHTSIVNRILVA--NNQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSApwDlps 153
Cdd:COG2319  183 DGTVRLWDLATGKLLRTLTGHTGAVRSVAFSpdGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSP--D--- 257

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530386988 154 tpcaeeaaaGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFRE 233
Cdd:COG2319  258 ---------GRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTG 328

                        250       260
                 ....*....|....*....|
gi 530386988 234 HRGSVICLECSRAAGTLAPG 253
Cdd:COG2319  329 HTGAVRSVAFSPDGKTLASG 348
WD40 COG2319
WD40 repeat [General function prediction only];
5-222 7.34e-50

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 173.17  E-value: 7.34e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530386988   5 GSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFcqledeAAF--------TCSAD 76
Cdd:COG2319  194 GKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRS------VAFspdgrllaSGSAD 267

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530386988  77 CTIRRWDVLTGQCLQVYRGHTSIVNRILVA--NNQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSApwdlpst 154
Cdd:COG2319  268 GTVRLWDLATGELLRTLTGHSGGVNSVAFSpdGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP------- 340

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530386988 155 pcaeeaaAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDI 222
Cdd:COG2319  341 -------DGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
4-251 4.40e-41

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 149.68  E-value: 4.40e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530386988   4 GGSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQL--EDEAAFTCSADCTIRR 81
Cdd:COG2319   25 LGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFspDGRLLASASADGTVRL 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530386988  82 WDVLTGQCLQVYRGHTSIVNRILVA--NNQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSapwdlpstpcaee 159
Cdd:COG2319  105 WDLATGLLLRTLTGHTGAVRSVAFSpdGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFS------------- 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530386988 160 aAAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVI 239
Cdd:COG2319  172 -PDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVR 250

                        250
                 ....*....|..
gi 530386988 240 CLECSRAAGTLA 251
Cdd:COG2319  251 SVAFSPDGRLLA 262
WD40 COG2319
WD40 repeat [General function prediction only];
4-182 3.41e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 136.58  E-value: 3.41e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530386988   4 GGSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFcqledeAAF--------TCSA 75
Cdd:COG2319  235 TGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNS------VAFspdgkllaSGSD 308

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530386988  76 DCTIRRWDVLTGQCLQVYRGHTSIVNRILVANN--QLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSApwdlps 153
Cdd:COG2319  309 DGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDgkTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP------ 382

                        170       180
                 ....*....|....*....|....*....
gi 530386988 154 tpcaeeaaAGGLLVTGSTDGTAKVWQVAS 182
Cdd:COG2319  383 --------DGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
22-251 3.48e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 122.71  E-value: 3.48e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530386988  22 SLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVT--FCQLEDEAAFTCSADCTIRRWDVLTGQCLQVYRGHTSI 99
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVAslAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530386988 100 VNRILVA--NNQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSApwdlpstpcaeeaaAGGLLVTGSTDGTAKV 177
Cdd:COG2319   81 VLSVAFSpdGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSP--------------DGKTLASGSADGTVRL 146

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530386988 178 WQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLECSRAAGTLA 251
Cdd:COG2319  147 WDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLA 220
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 89-241 1.16e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 116.28  E-value: 1.16e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530386988  89 CLQVYRGHTSIVNRILVANNQ--LFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSApwdlpstpcaeeaaAGGLL 166
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGklLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASA--------------DGTYL 66

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 530386988 167 VTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICL 241
Cdd:cd00200   67 ASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSV 141
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 185-251 1.93e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 55.03  E-value: 1.93e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 530386988 185 CHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLECSRAAGTLA 251
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLA 67
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 5-43 4.12e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.15  E-value: 4.12e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 530386988     5 GSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWS 43
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 108-222 8.81e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 51.24  E-value: 8.81e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530386988 108 NQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSapwdlpstpcaeeAAAGGLLVTGSTDGTAKVWQVASGCCHQ 187
Cdd:PLN00181 546 SQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYS-------------SADPTLLASGSDDGSVKLWSINQGVSIG 612

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 530386988 188 TLRghTGAVLCLVL---DTPGHTAFtGSTDATIRAWDI 222
Cdd:PLN00181 613 TIK--TKANICCVQfpsESGRSLAF-GSADHKVYYYDL 647
WD40 pfam00400
WD domain, G-beta repeat;
5-43 2.59e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.87  E-value: 2.59e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 530386988    5 GSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWS 43
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 182-221 2.76e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 2.76e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 530386988   182 SGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWD 221
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
183-221 1.00e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 1.00e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 530386988  183 GCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWD 221
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PHA03247 PHA03247
large tegument protein UL36; Provisional
 266-397 3.53e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.08  E-value: 3.53e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530386988  266 SGATHSSSTASRCTARCSTPPRTTAPCASGTCAGSEVPRGPLRPCAASRGSSATrwAAPPRPCSRPDPAGPLQTPAQTPS 345
Cdd:PHA03247 2561 PAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPP--SPLPPDTHAPDPPPPSPSPAANEP 2638

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 530386988  346 GSQSAPPCYPRWWRPMAGEGRGARKPGREESPSQASGFSlVARRRWERECSP 397
Cdd:PHA03247 2639 DPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQAS-SPPQRPRRRAAR 2689
PHA03247 PHA03247
large tegument protein UL36; Provisional
 251-355 3.99e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.08  E-value: 3.99e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530386988  251 APGPSTRSLESCGGCSGATHSSSTASRCTA--RCSTPPRTTAPcaSGTCAGSEVPRGPLRPCAASRGSSATRWAAPPRPC 328
Cdd:PHA03247 2628 PPSPSPAANEPDPHPPPTVPPPERPRDDPApgRVSRPRRARRL--GRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPP 2705

                          90       100
                  ....*....|....*....|....*...
gi 530386988  329 SRPDPAGPLQTPA-QTPSGSQSAPPCYP 355
Cdd:PHA03247 2706 PTPEPAPHALVSAtPLPPGPAAARQASP 2733
PTZ00421 PTZ00421
coronin; Provisional
 5-222 4.86e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 45.27  E-value: 4.86e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530386988   5 GSALRVCADHRGGINWLSLSpdgqrlltgsedGTARLWSTADGQCCA---LLQGHESY---VTFCQLEDEAAFTCSADCT 78
Cdd:PTZ00421  32 CSNTIACNDRFIAVPWQQLG------------STAVLKHTDYGKLASnppILLGQEGPiidVAFNPFDPQKLFTASEDGT 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530386988  79 IRRWDV----LTGQC------LQVYRGHTSIVNRILVANNQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAysap 148
Cdd:PTZ00421 100 IMGWGIpeegLTQNIsdpivhLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLE---- 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530386988 149 WDLpstpcaeeaaAGGLLVTGSTDGTAKVWQ------VASGCCHQTLRGHTgAVLCLVLDTPGHTAFTGSTDATIRAWDI 222
Cdd:PTZ00421 176 WNL----------DGSLLCTTSKDKKLNIIDprdgtiVSSVEAHASAKSQR-CLWAKRKDLIITLGCSKSQQRQIMLWDT 244
PHA02682 PHA02682
ORF080 virion core protein; Provisional
 240-355 6.55e-05

ORF080 virion core protein; Provisional


Pssm-ID: 177464 [Multi-domain]  Cd Length: 280  Bit Score: 44.47  E-value: 6.55e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530386988 240 CLECSRAAGTLAPGPStrslesCGGCSGATHSSSTASRCTAR-CSTPPRTTAPCASGTCAGSEVPRGPLRPCAASRGSSA 318
Cdd:PHA02682  72 CMQRPSGQSPLAPSPA------CAAPAPACPACAPAAPAPAVtCPAPAPACPPATAPTCPPPAVCPAPARPAPACPPSTR 145

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 530386988 319 TRWAAPPRPCSRPDPAG----------PLQTPAQTPSGSQSAPPCYP 355
Cdd:PHA02682 146 QCPPAPPLPTPKPAPAAkpiflhnqlpPPDYPAASCPTIETAPAASP 192
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 86-123 8.09e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 8.09e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 530386988    86 TGQCLQVYRGHTSIVNRILVA--NNQLFSSSYDRTARVWS 123
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSpdGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
87-123 5.54e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 5.54e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 530386988   87 GQCLQVYRGHTSIVNRILVA--NNQLFSSSYDRTARVWS 123
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSpdGKLLASGSDDGTVKVWD 39
PHA03247 PHA03247
large tegument protein UL36; Provisional
 246-404 5.71e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.23  E-value: 5.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530386988  246 AAGTLAPGPSTRSLESCGGCSGATHSSSTASRCTARCSTPPRTTAPCASGTCAGSEVPRGPLRPCAASRGSSATRW--AA 323
Cdd:PHA03247 2727 AARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWdpAD 2806

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530386988  324 PPRPCSRPDPAGPLQ----TPAQTPSGSQSAPPCYPRWWRPMAGEGRGARKPG---REESPSQASGFSLVAR-----RRW 391
Cdd:PHA03247 2807 PPAAVLAPAAALPPAaspaGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGgdvRRRPPSRSPAAKPAAParppvRRL 2886

                         170
                  ....*....|...
gi 530386988  392 ERECSPWGPPPFP 404
Cdd:PHA03247 2887 ARPAVSRSTESFA 2899
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 259-391 9.83e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 41.51  E-value: 9.83e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530386988 259 LESCGGCSGAThSSSTASRCTARcSTPPRTTAPCASGTCAGSEVPRGPLRPCAASRGSSA----TRWAAPPRPCSRPDPA 334
Cdd:PRK07764 381 LERRLGVAGGA-GAPAAAAPSAA-AAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPApappSPAGNAPAGGAPSPPP 458

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 530386988 335 GPLQTPAQTPSGSQSAPPCYPRWWRPMAG-EGRGARKPGREESPSQASGFSLVARRRW 391
Cdd:PRK07764 459 AAAPSAQPAPAPAAAPEPTAAPAPAPPAApAPAAAPAAPAAPAAPAGADDAATLRERW 516
PHA03247 PHA03247
large tegument protein UL36; Provisional
 235-379 1.67e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 1.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530386988  235 RGSVICLECSRAAGTLAPGPSTRSLESCGGCSGATHSSSTAS----RCTARCSTPPRTTAPCASG-TCAGSEVPRGPLRP 309
Cdd:PHA03247 2785 RPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGplppPTSAQPTAPPPPPGPPPPSlPLGGSVAPGGDVRR 2864

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530386988  310 CAASRgSSATRWAAPPRP----CSRPDPAGPLQTPAQTPSGSQ-------SAPPCYPRWWRPMAGEGRGARKPGREESPS 378
Cdd:PHA03247 2865 RPPSR-SPAAKPAAPARPpvrrLARPAVSRSTESFALPPDQPErppqpqaPPPPQPQPQPPPPPQPQPPPPPPPRPQPPL 2943


                  .
gi 530386988  379 Q 379
Cdd:PHA03247 2944 A 2944
PRK14959 PRK14959
DNA polymerase III subunits gamma and tau; Provisional
 283-384 1.70e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184923 [Multi-domain]  Cd Length: 624  Bit Score: 40.43  E-value: 1.70e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530386988 283 STPPRTTAPCASGTCAGSEVPRGPLRPCAASRGSSAT-RWAAP--PRPCSRPDPAGPLQTPAQTPSGSQSAPpcyprwwR 359
Cdd:PRK14959 379 SAPSGSAAEGPASGGAATIPTPGTQGPQGTAPAAGMTpSSAAPatPAPSAAPSPRVPWDDAPPAPPRSGIPP-------R 451

                         90       100
                 ....*....|....*....|....*
gi 530386988 360 PMAGEGRGARKPGREESPSQASGFS 384
Cdd:PRK14959 452 PAPRMPEASPVPGAPDSVASASDAP 476
PHA03378 PHA03378
EBNA-3B; Provisional
 245-404 1.84e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 40.44  E-value: 1.84e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530386988 245 RAAGTLAP--GPSTRSLESCGGCSGATHSSSTASRCTARCSTPPRTTAPCASGTCAGS-EVPRGPLRPCAASRGSSATRW 321
Cdd:PHA03378 699 RAPTPMRPpaAPPGRAQRPAAATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPpAAAPGRARPPAAAPGAPTPQP 778

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530386988 322 A--APPRPCSRPDPA-GPLQTPAQTPSGSQSAPPCYPRWWRPMAGEGR----GARKPGREESPSQASGfslvARRRwere 394
Cdd:PHA03378 779 PpqAPPAPQQRPRGApTPQPPPQAGPTSMQLMPRAAPGQQGPTKQILRqlltGGVKRGRPSLKKPAAL----ERQA---- 850

                        170
                 ....*....|
gi 530386988 395 csPWGPPPFP 404
Cdd:PHA03378 851 --AAGPTPSP 858
dnaA PRK14086
chromosomal replication initiator protein DnaA;
273-401 2.78e-03

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 39.81  E-value: 2.78e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530386988 273 STASRCTARCSTPPRTTAP----CASGTCAGSEVPRGPLRPCAASRGSSA--TRWAAP-----PRPCSRP---DPAGPLQ 338
Cdd:PRK14086  90 PSAGEPAPPPPHARRTSEPelprPGRRPYEGYGGPRADDRPPGLPRQDQLptARPAYPayqqrPEPGAWPraaDDYGWQQ 169

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 530386988 339 TPAQTPSGSQSAPPC----YPRWWRPMAGEGRGARKPGREesPSQASGFSLVARRRWEREcSPWGPP 401
Cdd:PRK14086 170 QRLGFPPRAPYASPAsyapEQERDREPYDAGRPEYDQRRR--DYDHPRPDWDRPRRDRTD-RPEPPP 233
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
245-381 3.31e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 39.83  E-value: 3.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530386988 245 RAAGTLAPGPSTRSLESCGGCSGATHSSSTASRCTARCSTPPRTTAPCASGTCAGSEVPRGplrpcAASRGSSATRWAAP 324
Cdd:PRK07003 386 RAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRGDDAADGD-----APVPAKANARASAD 460

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 530386988 325 PRPCSRpdPAGPLQTPAQTPSGSQSAPPCYPRWWRPMAGE-GRGARKPGREESPSQAS 381
Cdd:PRK07003 461 SRCDER--DAQPPADSGSASAPASDAPPDAAFEPAPRAAApSAATPAAVPDARAPAAA 516
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 126-178 4.81e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.60  E-value: 4.81e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 530386988   126 KGQMSREFRGHRNCVLTLAYSApwdlpstpcaeeaaAGGLLVTGSTDGTAKVW 178
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP--------------DGKYLASGSDDGTIKLW 39
PHA03247 PHA03247
large tegument protein UL36; Provisional
 284-404 5.48e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.15  E-value: 5.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530386988  284 TPPRTTAPCASGTCAGSEVPRGPLRPCAASRGSSATRWAAPPRPCS-------RPDPAGPLQTPAQTPSGSQSAPPCYPR 356
Cdd:PHA03247 2552 PPPLPPAAPPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARprapvddRGDPRGPAPPSPLPPDTHAPDPPPPSP 2631

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 530386988  357 WWRPM-AGEGRGARKPGREESPSQASGFSLVARRRWERECSPWGPPPFP 404
Cdd:PHA03247 2632 SPAANePDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPP 2680
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 244-366 8.81e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 38.61  E-value: 8.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530386988  244 SRAAGTLAPGPSTRSLESCGGCSGATHSSSTASRCTARCSTPPRTTAPCASGTCAGSEVPRGPLRPCAASRGSSATRWAA 323
Cdd:PHA03307  324 SSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDA 403

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 530386988  324 PPR-PCSRPDP----------AGPLQTPAQTPSGS---QSAPPCYPRWWRPMAGEGR 366
Cdd:PHA03307  404 TGRfPAGRPRPspldagaasgAFYARYPLLTPSGEpwpGSPPPPPGRVRYGGLGDSR 460
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 244-381 9.01e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 38.43  E-value: 9.01e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530386988 244 SRAAGTLAPGPSTRSLESCGGCSGATHSSSTASRCTARCSTPPRTTAPCASGTCAGSEVPRGPLRPCAASRGSSATRWAA 323
Cdd:PRK07764 628 APAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAA 707

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 530386988 324 PPRPCSRPDPAGPLQTPAQTPSGSQSAP---------PCYPRWWRPMAGEGRGARKPGREESPSQAS 381
Cdd:PRK07764 708 TPPAGQADDPAAQPPQAAQGASAPSPAAddpvplppePDDPPDPAGAPAQPPPPPAPAPAAAPAAAP 774
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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