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Conserved domains on  [gi|530361198|ref|XP_005245975|]
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beta/gamma crystallin domain-containing protein 2 isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
beta-trefoil_Ricin_CRYBG2 cd23465
ricin B-type lectin domain, beta-trefoil fold, found in beta/gamma crystallin ...
1526-1661 9.20e-90

ricin B-type lectin domain, beta-trefoil fold, found in beta/gamma crystallin domain-containing protein 2 (CRYBG2) and similar proteins; CRYBG2, also called absent in melanoma 1-like protein (AIM1L), is a beta/gamma-crystallin family protein with a ricin B-type lectin domain at the C-terminus. The ricin B-type lectin domain shows a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain may harbor a sugar-binding pocket.


:

Pssm-ID: 467343  Cd Length: 136  Bit Score: 287.15  E-value: 9.20e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198 1526 QRRVYFRLWNAALGGFLAVPDHVEDMKAGRVVVADPQAGGSCIWYYEDGLLKNQMAPTMSLQVIGPPSPGSKVVLWAESR 1605
Cdd:cd23465     1 QRRVYFRLRNRELGLYLAVPDGVEDMKAGRVVVTEQQEGMSHVWFYEDGLLKNQMAPTMSLQVIGPPDNGAKVVLWSETR 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 530361198 1606 LPRQTWSISESGHICSQMFEGQILDVKGGRGYDRDHVVLWEPDEDRASQIWTIHVL 1661
Cdd:cd23465    81 QPRQTWSIQPSGHILSQMFEGMILDVKGGRTYDRDHVVLWEVSEERPSQIWDMEVL 136
Crystall pfam00030
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ...
1169-1255 5.64e-36

Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.


:

Pssm-ID: 459639  Cd Length: 82  Bit Score: 131.46  E-value: 5.64e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  1169 RAVVYEAPGFQGRSWEVSRDIYNLQQpedsqSPHLASVGSLRVLGGCWVGYEKEGFRGHQYLLEEGEYPDWSHWGGYDEL 1248
Cdd:pfam00030    1 KIVLYEKENFQGRSIELTDDCPSLQE-----RGFNSRVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAPNDR 75

                   ....*..
gi 530361198  1249 LTSLRVI 1255
Cdd:pfam00030   76 IGSLRPI 82
Crystall pfam00030
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ...
1264-1344 2.38e-29

Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.


:

Pssm-ID: 459639  Cd Length: 82  Bit Score: 112.59  E-value: 2.38e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  1264 VVLFEAMDFEGHGVEVSKALPDVELVQHGPSTQAIHVLSGVWVAYQEVGFSGEQYVLEKGVYRNCEDWGAGNSTLASLQP 1343
Cdd:pfam00030    2 IVLYEKENFQGRSIELTDDCPSLQERGFNSRVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAPNDRIGSLRP 81

                   .
gi 530361198  1344 V 1344
Cdd:pfam00030   82 I 82
Crystall pfam00030
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ...
1444-1524 5.30e-25

Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.


:

Pssm-ID: 459639  Cd Length: 82  Bit Score: 99.88  E-value: 5.30e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  1444 SIFLYGLECFEGKEIELSREVRSLQAEGFNNHVLSVRIKGGIWVLCEHSDFRGRQWLVGSCEITNWLTYSG-TQRVGSLY 1522
Cdd:pfam00030    1 KIVLYEKENFQGRSIELTDDCPSLQERGFNSRVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGApNDRIGSLR 80

                   ..
gi 530361198  1523 PI 1524
Cdd:pfam00030   81 PI 82
Crystall pfam00030
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ...
1075-1155 9.50e-22

Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.


:

Pssm-ID: 459639  Cd Length: 82  Bit Score: 90.63  E-value: 9.50e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  1075 ISLFSEEGLKGEQVKLTEALKNSQGLEKPLQVASATVSAGLWLLYPKPLFEDTPYILEPGEYPTSEAWGTSDPSVGSLKP 1154
Cdd:pfam00030    2 IVLYEKENFQGRSIELTDDCPSLQERGFNSRVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAPNDRIGSLRP 81

                   .
gi 530361198  1155 M 1155
Cdd:pfam00030   82 I 82
Crystall pfam00030
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ...
1357-1436 5.47e-19

Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.


:

Pssm-ID: 459639  Cd Length: 82  Bit Score: 82.93  E-value: 5.47e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  1357 KIQLFSRPDFLGDHFSFEDDQAALPASFRP---QSCRVHGGSWILFDETNFEGDQHILSEGEFPTLTAMGCLASTVlGSL 1433
Cdd:pfam00030    1 KIVLYEKENFQGRSIELTDDCPSLQERGFNsrvNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAPNDRI-GSL 79

                   ...
gi 530361198  1434 QKV 1436
Cdd:pfam00030   80 RPI 82
Crystall super family cl02528
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ...
987-1066 2.31e-15

Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.


The actual alignment was detected with superfamily member pfam00030:

Pssm-ID: 470604  Cd Length: 82  Bit Score: 72.53  E-value: 2.31e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198   987 KVIFFSESGCQGSGREVWGDI--VDASGWAP-VASIRVVRGCWVLYEEPEFRGQKLVLPEGdmELRTPgTKWSPQG--IG 1061
Cdd:pfam00030    1 KIVLYEKENFQGRSIELTDDCpsLQERGFNSrVNSIRVLSGAWVLYEHPNFRGRQYVLEPG--EYPDW-SDWGAPNdrIG 77

                   ....*
gi 530361198  1062 SLRRV 1066
Cdd:pfam00030   78 SLRPI 82
PHA03247 super family cl33720
large tegument protein UL36; Provisional
248-710 1.86e-11

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 69.58  E-value: 1.86e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  248 PPASHLPRPTagGPRSTGLGSTVGAALRqlPETGTAELKDSSALASTGIPASAhlpknqdAPAACPDRDQGRAPDARACE 327
Cdd:PHA03247 2569 PPPRPAPRPS--EPAVTSRARRPDAPPQ--SARPRAPVDDRGDPRGPAPPSPL-------PPDTHAPDPPPPSPSPAANE 2637
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  328 LwqvlGAPSSTELPLQTSQGQASVPSSPRLETHVPSPG-LTHPAKQPVVPTHPGAR-----LTPLVLPPKKKDGPVDPPA 401
Cdd:PHA03247 2638 P----DPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGrAAQASSPPQRPRRRAARptvgsLTSLADPPPPPPTPEPAPH 2713
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  402 ATVlpmvrsehvTVPGQPPAPSTTRRKDVPSPGGLSAPSSPRNKFVQNSENVPVLPFTqrevVKGPGAPA-----ASSPT 476
Cdd:PHA03247 2714 ALV---------SATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPT----TAGPPAPAppaapAAGPP 2780
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  477 RKEVVQGSSASAASSPTwKEVVKGPGAPAASSPTQKEVVQGSSAPAALFPTWKEVVKGPGAPDASFPTWKEVVKG---PG 553
Cdd:PHA03247 2781 RRLTRPAVASLSESRES-LPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGsvaPG 2859
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  554 APAASSPTQKEVVQGSGAPA--ALSTTPKEVVKGPGAPAASSPTQKEVVKGPCAPAASSPTQKEVVQGSGAPA----ALS 627
Cdd:PHA03247 2860 GDVRRRPPSRSPAAKPAAPArpPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPppppPRP 2939
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  628 PKSTEVVQGPKGSSSIQKEAVQGIAGSLAPPLTKEETVQGPiAPATSLPKQDKGVQDSEGSPISSLTQ--KEVVQDPDAL 705
Cdd:PHA03247 2940 QPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVP-QPAPSREAPASSTPPLTGHSLSRVSSwaSSLALHEETD 3018

                  ....*
gi 530361198  706 PAPSS 710
Cdd:PHA03247 3019 PPPVS 3023
 
Name Accession Description Interval E-value
beta-trefoil_Ricin_CRYBG2 cd23465
ricin B-type lectin domain, beta-trefoil fold, found in beta/gamma crystallin ...
1526-1661 9.20e-90

ricin B-type lectin domain, beta-trefoil fold, found in beta/gamma crystallin domain-containing protein 2 (CRYBG2) and similar proteins; CRYBG2, also called absent in melanoma 1-like protein (AIM1L), is a beta/gamma-crystallin family protein with a ricin B-type lectin domain at the C-terminus. The ricin B-type lectin domain shows a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain may harbor a sugar-binding pocket.


Pssm-ID: 467343  Cd Length: 136  Bit Score: 287.15  E-value: 9.20e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198 1526 QRRVYFRLWNAALGGFLAVPDHVEDMKAGRVVVADPQAGGSCIWYYEDGLLKNQMAPTMSLQVIGPPSPGSKVVLWAESR 1605
Cdd:cd23465     1 QRRVYFRLRNRELGLYLAVPDGVEDMKAGRVVVTEQQEGMSHVWFYEDGLLKNQMAPTMSLQVIGPPDNGAKVVLWSETR 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 530361198 1606 LPRQTWSISESGHICSQMFEGQILDVKGGRGYDRDHVVLWEPDEDRASQIWTIHVL 1661
Cdd:cd23465    81 QPRQTWSIQPSGHILSQMFEGMILDVKGGRTYDRDHVVLWEVSEERPSQIWDMEVL 136
Crystall pfam00030
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ...
1169-1255 5.64e-36

Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.


Pssm-ID: 459639  Cd Length: 82  Bit Score: 131.46  E-value: 5.64e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  1169 RAVVYEAPGFQGRSWEVSRDIYNLQQpedsqSPHLASVGSLRVLGGCWVGYEKEGFRGHQYLLEEGEYPDWSHWGGYDEL 1248
Cdd:pfam00030    1 KIVLYEKENFQGRSIELTDDCPSLQE-----RGFNSRVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAPNDR 75

                   ....*..
gi 530361198  1249 LTSLRVI 1255
Cdd:pfam00030   76 IGSLRPI 82
Crystall pfam00030
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ...
1264-1344 2.38e-29

Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.


Pssm-ID: 459639  Cd Length: 82  Bit Score: 112.59  E-value: 2.38e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  1264 VVLFEAMDFEGHGVEVSKALPDVELVQHGPSTQAIHVLSGVWVAYQEVGFSGEQYVLEKGVYRNCEDWGAGNSTLASLQP 1343
Cdd:pfam00030    2 IVLYEKENFQGRSIELTDDCPSLQERGFNSRVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAPNDRIGSLRP 81

                   .
gi 530361198  1344 V 1344
Cdd:pfam00030   82 I 82
XTALbg smart00247
Beta/gamma crystallins; Beta/gamma crystallins
1169-1255 3.25e-27

Beta/gamma crystallins; Beta/gamma crystallins


Pssm-ID: 214583  Cd Length: 82  Bit Score: 106.44  E-value: 3.25e-27
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198   1169 RAVVYEAPGFQGRSWEVSRDIYNLQqpeDSQSPHLasVGSLRVLGGCWVGYEKEGFRGHQYLLEEGEYPDWSHWGGYDEL 1248
Cdd:smart00247    1 KITLYEDENFQGRSYELSDDCPSLQ---DYGSRDN--VSSVRVESGCWVLYEQPNYRGRQYVLEPGEYPDYQEWGGFNDQ 75

                    ....*..
gi 530361198   1249 LTSLRVI 1255
Cdd:smart00247   76 ISSIRRI 82
Crystall pfam00030
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ...
1444-1524 5.30e-25

Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.


Pssm-ID: 459639  Cd Length: 82  Bit Score: 99.88  E-value: 5.30e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  1444 SIFLYGLECFEGKEIELSREVRSLQAEGFNNHVLSVRIKGGIWVLCEHSDFRGRQWLVGSCEITNWLTYSG-TQRVGSLY 1522
Cdd:pfam00030    1 KIVLYEKENFQGRSIELTDDCPSLQERGFNSRVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGApNDRIGSLR 80

                   ..
gi 530361198  1523 PI 1524
Cdd:pfam00030   81 PI 82
Crystall pfam00030
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ...
1075-1155 9.50e-22

Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.


Pssm-ID: 459639  Cd Length: 82  Bit Score: 90.63  E-value: 9.50e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  1075 ISLFSEEGLKGEQVKLTEALKNSQGLEKPLQVASATVSAGLWLLYPKPLFEDTPYILEPGEYPTSEAWGTSDPSVGSLKP 1154
Cdd:pfam00030    2 IVLYEKENFQGRSIELTDDCPSLQERGFNSRVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAPNDRIGSLRP 81

                   .
gi 530361198  1155 M 1155
Cdd:pfam00030   82 I 82
Crystall pfam00030
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ...
1357-1436 5.47e-19

Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.


Pssm-ID: 459639  Cd Length: 82  Bit Score: 82.93  E-value: 5.47e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  1357 KIQLFSRPDFLGDHFSFEDDQAALPASFRP---QSCRVHGGSWILFDETNFEGDQHILSEGEFPTLTAMGCLASTVlGSL 1433
Cdd:pfam00030    1 KIVLYEKENFQGRSIELTDDCPSLQERGFNsrvNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAPNDRI-GSL 79

                   ...
gi 530361198  1434 QKV 1436
Cdd:pfam00030   80 RPI 82
XTALbg smart00247
Beta/gamma crystallins; Beta/gamma crystallins
1445-1524 2.56e-17

Beta/gamma crystallins; Beta/gamma crystallins


Pssm-ID: 214583  Cd Length: 82  Bit Score: 78.32  E-value: 2.56e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198   1445 IFLYGLECFEGKEIELSREVRSLQAEGFNNHVLSVRIKGGIWVLCEHSDFRGRQWLVGSCEITNWLTYSGTQ-RVGSLYP 1523
Cdd:smart00247    2 ITLYEDENFQGRSYELSDDCPSLQDYGSRDNVSSVRVESGCWVLYEQPNYRGRQYVLEPGEYPDYQEWGGFNdQISSIRR 81

                    .
gi 530361198   1524 I 1524
Cdd:smart00247   82 I 82
Crystall pfam00030
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ...
987-1066 2.31e-15

Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.


Pssm-ID: 459639  Cd Length: 82  Bit Score: 72.53  E-value: 2.31e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198   987 KVIFFSESGCQGSGREVWGDI--VDASGWAP-VASIRVVRGCWVLYEEPEFRGQKLVLPEGdmELRTPgTKWSPQG--IG 1061
Cdd:pfam00030    1 KIVLYEKENFQGRSIELTDDCpsLQERGFNSrVNSIRVLSGAWVLYEHPNFRGRQYVLEPG--EYPDW-SDWGAPNdrIG 77

                   ....*
gi 530361198  1062 SLRRV 1066
Cdd:pfam00030   78 SLRPI 82
XTALbg smart00247
Beta/gamma crystallins; Beta/gamma crystallins
1357-1433 5.08e-15

Beta/gamma crystallins; Beta/gamma crystallins


Pssm-ID: 214583  Cd Length: 82  Bit Score: 71.77  E-value: 5.08e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198   1357 KIQLFSRPDFLGDHFSFEDDQAALPASFRP---QSCRVHGGSWILFDETNFEGDQHILSEGEFPTLTAMGCLASTVlGSL 1433
Cdd:smart00247    1 KITLYEDENFQGRSYELSDDCPSLQDYGSRdnvSSVRVESGCWVLYEQPNYRGRQYVLEPGEYPDYQEWGGFNDQI-SSI 79
XTALbg smart00247
Beta/gamma crystallins; Beta/gamma crystallins
1264-1344 6.42e-15

Beta/gamma crystallins; Beta/gamma crystallins


Pssm-ID: 214583  Cd Length: 82  Bit Score: 71.39  E-value: 6.42e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198   1264 VVLFEAMDFEGHGVEVSKALPDVELVQHGPSTQAIHVLSGVWVAYQEVGFSGEQYVLEKGVYRNCEDWGAGNSTLASLQP 1343
Cdd:smart00247    2 ITLYEDENFQGRSYELSDDCPSLQDYGSRDNVSSVRVESGCWVLYEQPNYRGRQYVLEPGEYPDYQEWGGFNDQISSIRR 81

                    .
gi 530361198   1344 V 1344
Cdd:smart00247   82 I 82
PHA03247 PHA03247
large tegument protein UL36; Provisional
248-710 1.86e-11

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 69.58  E-value: 1.86e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  248 PPASHLPRPTagGPRSTGLGSTVGAALRqlPETGTAELKDSSALASTGIPASAhlpknqdAPAACPDRDQGRAPDARACE 327
Cdd:PHA03247 2569 PPPRPAPRPS--EPAVTSRARRPDAPPQ--SARPRAPVDDRGDPRGPAPPSPL-------PPDTHAPDPPPPSPSPAANE 2637
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  328 LwqvlGAPSSTELPLQTSQGQASVPSSPRLETHVPSPG-LTHPAKQPVVPTHPGAR-----LTPLVLPPKKKDGPVDPPA 401
Cdd:PHA03247 2638 P----DPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGrAAQASSPPQRPRRRAARptvgsLTSLADPPPPPPTPEPAPH 2713
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  402 ATVlpmvrsehvTVPGQPPAPSTTRRKDVPSPGGLSAPSSPRNKFVQNSENVPVLPFTqrevVKGPGAPA-----ASSPT 476
Cdd:PHA03247 2714 ALV---------SATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPT----TAGPPAPAppaapAAGPP 2780
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  477 RKEVVQGSSASAASSPTwKEVVKGPGAPAASSPTQKEVVQGSSAPAALFPTWKEVVKGPGAPDASFPTWKEVVKG---PG 553
Cdd:PHA03247 2781 RRLTRPAVASLSESRES-LPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGsvaPG 2859
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  554 APAASSPTQKEVVQGSGAPA--ALSTTPKEVVKGPGAPAASSPTQKEVVKGPCAPAASSPTQKEVVQGSGAPA----ALS 627
Cdd:PHA03247 2860 GDVRRRPPSRSPAAKPAAPArpPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPppppPRP 2939
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  628 PKSTEVVQGPKGSSSIQKEAVQGIAGSLAPPLTKEETVQGPiAPATSLPKQDKGVQDSEGSPISSLTQ--KEVVQDPDAL 705
Cdd:PHA03247 2940 QPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVP-QPAPSREAPASSTPPLTGHSLSRVSSwaSSLALHEETD 3018

                  ....*
gi 530361198  706 PAPSS 710
Cdd:PHA03247 3019 PPPVS 3023
XTALbg smart00247
Beta/gamma crystallins; Beta/gamma crystallins
987-1066 7.71e-11

Beta/gamma crystallins; Beta/gamma crystallins


Pssm-ID: 214583  Cd Length: 82  Bit Score: 59.83  E-value: 7.71e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198    987 KVIFFSESGCQGSGREVWGD---IVDASGWAPVASIRVVRGCWVLYEEPEFRGQKLVLPEGdmELRTPGTkWSPQG--IG 1061
Cdd:smart00247    1 KITLYEDENFQGRSYELSDDcpsLQDYGSRDNVSSVRVESGCWVLYEQPNYRGRQYVLEPG--EYPDYQE-WGGFNdqIS 77

                    ....*
gi 530361198   1062 SLRRV 1066
Cdd:smart00247   78 SIRRI 82
XTALbg smart00247
Beta/gamma crystallins; Beta/gamma crystallins
1075-1155 6.93e-10

Beta/gamma crystallins; Beta/gamma crystallins


Pssm-ID: 214583  Cd Length: 82  Bit Score: 57.13  E-value: 6.93e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198   1075 ISLFSEEGLKGEQVKLTEALKNSQGLEKPLQVASATVSAGLWLLYPKPLFEDTPYILEPGEYPTSEAWGTSDPSVGSLKP 1154
Cdd:smart00247    2 ITLYEDENFQGRSYELSDDCPSLQDYGSRDNVSSVRVESGCWVLYEQPNYRGRQYVLEPGEYPDYQEWGGFNDQISSIRR 81

                    .
gi 530361198   1155 M 1155
Cdd:smart00247   82 I 82
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
293-742 1.28e-07

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 56.85  E-value: 1.28e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198   293 STGIPASAHLPKNQDAPAACpdrdqgrAPdaracelwQVLGAPSSTELPLQTSQGQASVPSSPRLE---THVPSPGLTHP 369
Cdd:pfam05109  445 TTGLPSSTHVPTNLTAPAST-------GP--------TVSTADVTSPTPAGTTSGASPVTPSPSPRdngTESKAPDMTSP 509
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198   370 AKQPVVPTHPGARLTPLVLPPKKKdgPVDPPAATVLPmvrSEHVTVPgQPPAPSTTRRKDVPSPgglsapssprnkfvqn 449
Cdd:pfam05109  510 TSAVTTPTPNATSPTPAVTTPTPN--ATSPTLGKTSP---TSAVTTP-TPNATSPTPAVTTPTP---------------- 567
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198   450 SENVPVLPFTQREVVKGPGAPAASSPTRKEVV--QGSSASAASSPTWKEVVKGPGAPAASSPT--QKEVVQGSSAPAALF 525
Cdd:pfam05109  568 NATIPTLGKTSPTSAVTTPTPNATSPTVGETSpqANTTNHTLGGTSSTPVVTSPPKNATSAVTtgQHNITSSSTSSMSLR 647
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198   526 PTWKEVVKGPGAPDASfptwkeVVKGPGAPAASSPTQKEVVQGSGApaalSTTPKEVVKGPGAPAASSPTQkevVKGPCA 605
Cdd:pfam05109  648 PSSISETLSPSTSDNS------TSHMPLLTSAHPTGGENITQVTPA----STSTHHVSTSSPAPRPGTTSQ---ASGPGN 714
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198   606 PAASS-PTQKEVVQGSGAPAALSPkstevvQGPKGsssiQKEAVQGI--AGSLAPPLTKEETVQGPIAPATSLPKQDKGV 682
Cdd:pfam05109  715 SSTSTkPGEVNVTKGTPPKNATSP------QAPSG----QKTAVPTVtsTGGKANSTTGGKHTTGHGARTSTEPTTDYGG 784
                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198   683 qdsegspiSSLTQKEVVQDPDALPAPSSSvdRVSPSPGGTPAPVPTgAEASTESQLVSDP 742
Cdd:pfam05109  785 --------DSTTPRTRYNATTYLPPSTSS--KLRPRWTFTSPPVTT-AQATVPVPPTSQP 833
Ricin_B_lectin pfam00652
Ricin-type beta-trefoil lectin domain;
1569-1656 5.97e-06

Ricin-type beta-trefoil lectin domain;


Pssm-ID: 395527 [Multi-domain]  Cd Length: 126  Bit Score: 47.14  E-value: 5.97e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  1569 W-YYEDGLLKNqMAPTMSLQVIGPpSPGSKVVLWA-ESRLPRQTWSISESGHICSQMFEGQILDVKGGrGYDRDHVVLWE 1646
Cdd:pfam00652   40 WtLTGDGTIRS-VASDLCLDVGST-ADGAKVVLWPcHPGNGNQRWRYDEDGTQIRNPQSGKCLDVSGA-GTSNGKVILWT 116
                           90
                   ....*....|
gi 530361198  1647 PDEDRASQIW 1656
Cdd:pfam00652  117 CDSGNPNQQW 126
 
Name Accession Description Interval E-value
beta-trefoil_Ricin_CRYBG2 cd23465
ricin B-type lectin domain, beta-trefoil fold, found in beta/gamma crystallin ...
1526-1661 9.20e-90

ricin B-type lectin domain, beta-trefoil fold, found in beta/gamma crystallin domain-containing protein 2 (CRYBG2) and similar proteins; CRYBG2, also called absent in melanoma 1-like protein (AIM1L), is a beta/gamma-crystallin family protein with a ricin B-type lectin domain at the C-terminus. The ricin B-type lectin domain shows a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain may harbor a sugar-binding pocket.


Pssm-ID: 467343  Cd Length: 136  Bit Score: 287.15  E-value: 9.20e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198 1526 QRRVYFRLWNAALGGFLAVPDHVEDMKAGRVVVADPQAGGSCIWYYEDGLLKNQMAPTMSLQVIGPPSPGSKVVLWAESR 1605
Cdd:cd23465     1 QRRVYFRLRNRELGLYLAVPDGVEDMKAGRVVVTEQQEGMSHVWFYEDGLLKNQMAPTMSLQVIGPPDNGAKVVLWSETR 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 530361198 1606 LPRQTWSISESGHICSQMFEGQILDVKGGRGYDRDHVVLWEPDEDRASQIWTIHVL 1661
Cdd:cd23465    81 QPRQTWSIQPSGHILSQMFEGMILDVKGGRTYDRDHVVLWEVSEERPSQIWDMEVL 136
beta-trefoil_Ricin_CRYBG cd23430
ricin B-type lectin domain, beta-trefoil fold, found in the beta/gamma crystallin ...
1529-1660 5.30e-75

ricin B-type lectin domain, beta-trefoil fold, found in the beta/gamma crystallin domain-containing protein (CRYBG) family; The CRYBG family includes three members: CRYBG1, CRYBG2, and CRYBG3/vlAKAP. CRYBG1, also called absent in melanoma 1 protein (AIM1), may function as a suppressor of malignant melanoma. It may exert its effects through interactions with the cytoskeleton. CRYBG2 is also called absent in melanoma 1-like protein (AIM1L). CRYBG3/vlAKAP, also called very large A-kinase anchor protein, is an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA). It binds to the dimeric RII-alpha regulatory subunit of PKA (PRKAR2A/PRKAR2B). CRYBG proteins belong to the beta/gamma-crystallin family. They all contain a ricin B-type lectin domain with a beta-trefoil fold at the C-terminus. The beta-trefoil fold is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain may harbor a sugar-binding pocket.


Pssm-ID: 467308 [Multi-domain]  Cd Length: 133  Bit Score: 244.81  E-value: 5.30e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198 1529 VYFRLWNAALGGFLAVPDHVEDmKAGRVVVADPQAG-GSCIWYYEDGLLKNQMAPTMSLQVIGPPS-PGSKVVLWAESRL 1606
Cdd:cd23430     1 VYFRLRNKATGLFLSVNGNLED-LKLLRVQVMPDVGaDDQIWYYQEGLIKCRIAEDCCLTVIGSLVtPGSKVGLWLEQNA 79
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 530361198 1607 PRQTWSISESGHICSQMFEGQILDVKGGRGYDRDHVVLWEPDEDRASQIWTIHV 1660
Cdd:cd23430    80 DRQFWSLKSDGRIYSKLKPNLVLDVKGGTQYDQNHVILNTPSEEKFTQVWEIMV 133
Crystall pfam00030
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ...
1169-1255 5.64e-36

Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.


Pssm-ID: 459639  Cd Length: 82  Bit Score: 131.46  E-value: 5.64e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  1169 RAVVYEAPGFQGRSWEVSRDIYNLQQpedsqSPHLASVGSLRVLGGCWVGYEKEGFRGHQYLLEEGEYPDWSHWGGYDEL 1248
Cdd:pfam00030    1 KIVLYEKENFQGRSIELTDDCPSLQE-----RGFNSRVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAPNDR 75

                   ....*..
gi 530361198  1249 LTSLRVI 1255
Cdd:pfam00030   76 IGSLRPI 82
beta-trefoil_Ricin_vlAKAP cd23463
ricin B-type lectin domain, beta-trefoil fold, found in very large A-kinase anchor protein ...
1526-1661 2.56e-33

ricin B-type lectin domain, beta-trefoil fold, found in very large A-kinase anchor protein (vlAKAP) and similar proteins; vlAKAP, also called beta/gamma crystallin domain-containing protein 3 (CRYBG3), is an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA). It binds to the dimeric RII-alpha regulatory subunit of PKA (PRKAR2A/PRKAR2B). vlAKAP belongs to the beta/gamma-crystallin family. It contains a ricin B-type lectin domain at the C-terminus. The ricin B-type lectin domain shows a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain may harbor a sugar-binding pocket.


Pssm-ID: 467341  Cd Length: 136  Bit Score: 126.01  E-value: 2.56e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198 1526 QRRVYFRLWNAALGGFLAVPDHVEDMKAGRVVVAdpQAGGSC--IWYYEDGLLKNQMAPTmSLQVIG-PPSPGSKVVLWA 1602
Cdd:cd23463     1 QPRVYLRIKNRAQGLYLTTEGNLADPRATSVCVS--QYNGKDtqIWYYCRGLLKSKANDA-CLDVIGgKDNPGSKVALWT 77
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 530361198 1603 ESRLPRQTWSISESGHICSQMFEGQILDVKGGRGYDRDHVVLWEPDEDRASQIWTIHVL 1661
Cdd:cd23463    78 EHGKTHQKWRINEDGTISSHLSDDLVLDLKGGNYYDKDHLIVNNPEEDQQTQKWDIELL 136
Crystall pfam00030
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ...
1264-1344 2.38e-29

Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.


Pssm-ID: 459639  Cd Length: 82  Bit Score: 112.59  E-value: 2.38e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  1264 VVLFEAMDFEGHGVEVSKALPDVELVQHGPSTQAIHVLSGVWVAYQEVGFSGEQYVLEKGVYRNCEDWGAGNSTLASLQP 1343
Cdd:pfam00030    2 IVLYEKENFQGRSIELTDDCPSLQERGFNSRVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAPNDRIGSLRP 81

                   .
gi 530361198  1344 V 1344
Cdd:pfam00030   82 I 82
beta-trefoil_Ricin_CRYBG1 cd23464
ricin B-type lectin domain, beta-trefoil fold, found in beta/gamma crystallin ...
1526-1661 3.01e-27

ricin B-type lectin domain, beta-trefoil fold, found in beta/gamma crystallin domain-containing protein 1 (CRYBG1) and similar proteins; CRYBG1, also called absent in melanoma 1 protein (AIM1), may function as a suppressor of malignant melanoma. It may exert its effects through interactions with the cytoskeleton. CRYBG1 belongs to the beta/gamma-crystallin family. It contains a ricin B-type lectin domain at the C-terminus. The ricin B-type lectin domain shows a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain may harbor a sugar-binding pocket.


Pssm-ID: 467342  Cd Length: 137  Bit Score: 108.35  E-value: 3.01e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198 1526 QRRVYFRLWNAALGGFLAVPDHVEDMKAGRVVVADPQAGGSCIWYYEDGLLKNQMAPTMSLQVIGP-PSPGSKVVLWAES 1604
Cdd:cd23464     1 QKRVYFRLRNKETGCFMSTNGNLDDLKLLRIQVLEDTGSDDQIWVYQDGLIRCRMAEDCCLETVGNlVTAGSKLGLSLEQ 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 530361198 1605 RLPRQTWSISESGHICSQMFEGQILDVKGGRGYDRDHVVLWEPDEDRASQIWTIHVL 1661
Cdd:cd23464    81 GKDNQFWSITSDGRIYSKLKPDLVLDIKGGQQYDQNHVILNTFDEEKLTQRWEVEIL 137
XTALbg smart00247
Beta/gamma crystallins; Beta/gamma crystallins
1169-1255 3.25e-27

Beta/gamma crystallins; Beta/gamma crystallins


Pssm-ID: 214583  Cd Length: 82  Bit Score: 106.44  E-value: 3.25e-27
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198   1169 RAVVYEAPGFQGRSWEVSRDIYNLQqpeDSQSPHLasVGSLRVLGGCWVGYEKEGFRGHQYLLEEGEYPDWSHWGGYDEL 1248
Cdd:smart00247    1 KITLYEDENFQGRSYELSDDCPSLQ---DYGSRDN--VSSVRVESGCWVLYEQPNYRGRQYVLEPGEYPDYQEWGGFNDQ 75

                    ....*..
gi 530361198   1249 LTSLRVI 1255
Cdd:smart00247   76 ISSIRRI 82
Crystall pfam00030
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ...
1444-1524 5.30e-25

Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.


Pssm-ID: 459639  Cd Length: 82  Bit Score: 99.88  E-value: 5.30e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  1444 SIFLYGLECFEGKEIELSREVRSLQAEGFNNHVLSVRIKGGIWVLCEHSDFRGRQWLVGSCEITNWLTYSG-TQRVGSLY 1522
Cdd:pfam00030    1 KIVLYEKENFQGRSIELTDDCPSLQERGFNSRVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGApNDRIGSLR 80

                   ..
gi 530361198  1523 PI 1524
Cdd:pfam00030   81 PI 82
Crystall pfam00030
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ...
1075-1155 9.50e-22

Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.


Pssm-ID: 459639  Cd Length: 82  Bit Score: 90.63  E-value: 9.50e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  1075 ISLFSEEGLKGEQVKLTEALKNSQGLEKPLQVASATVSAGLWLLYPKPLFEDTPYILEPGEYPTSEAWGTSDPSVGSLKP 1154
Cdd:pfam00030    2 IVLYEKENFQGRSIELTDDCPSLQERGFNSRVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAPNDRIGSLRP 81

                   .
gi 530361198  1155 M 1155
Cdd:pfam00030   82 I 82
Crystall pfam00030
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ...
1357-1436 5.47e-19

Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.


Pssm-ID: 459639  Cd Length: 82  Bit Score: 82.93  E-value: 5.47e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  1357 KIQLFSRPDFLGDHFSFEDDQAALPASFRP---QSCRVHGGSWILFDETNFEGDQHILSEGEFPTLTAMGCLASTVlGSL 1433
Cdd:pfam00030    1 KIVLYEKENFQGRSIELTDDCPSLQERGFNsrvNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAPNDRI-GSL 79

                   ...
gi 530361198  1434 QKV 1436
Cdd:pfam00030   80 RPI 82
XTALbg smart00247
Beta/gamma crystallins; Beta/gamma crystallins
1445-1524 2.56e-17

Beta/gamma crystallins; Beta/gamma crystallins


Pssm-ID: 214583  Cd Length: 82  Bit Score: 78.32  E-value: 2.56e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198   1445 IFLYGLECFEGKEIELSREVRSLQAEGFNNHVLSVRIKGGIWVLCEHSDFRGRQWLVGSCEITNWLTYSGTQ-RVGSLYP 1523
Cdd:smart00247    2 ITLYEDENFQGRSYELSDDCPSLQDYGSRDNVSSVRVESGCWVLYEQPNYRGRQYVLEPGEYPDYQEWGGFNdQISSIRR 81

                    .
gi 530361198   1524 I 1524
Cdd:smart00247   82 I 82
Crystall pfam00030
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ...
987-1066 2.31e-15

Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.


Pssm-ID: 459639  Cd Length: 82  Bit Score: 72.53  E-value: 2.31e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198   987 KVIFFSESGCQGSGREVWGDI--VDASGWAP-VASIRVVRGCWVLYEEPEFRGQKLVLPEGdmELRTPgTKWSPQG--IG 1061
Cdd:pfam00030    1 KIVLYEKENFQGRSIELTDDCpsLQERGFNSrVNSIRVLSGAWVLYEHPNFRGRQYVLEPG--EYPDW-SDWGAPNdrIG 77

                   ....*
gi 530361198  1062 SLRRV 1066
Cdd:pfam00030   78 SLRPI 82
XTALbg smart00247
Beta/gamma crystallins; Beta/gamma crystallins
1357-1433 5.08e-15

Beta/gamma crystallins; Beta/gamma crystallins


Pssm-ID: 214583  Cd Length: 82  Bit Score: 71.77  E-value: 5.08e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198   1357 KIQLFSRPDFLGDHFSFEDDQAALPASFRP---QSCRVHGGSWILFDETNFEGDQHILSEGEFPTLTAMGCLASTVlGSL 1433
Cdd:smart00247    1 KITLYEDENFQGRSYELSDDCPSLQDYGSRdnvSSVRVESGCWVLYEQPNYRGRQYVLEPGEYPDYQEWGGFNDQI-SSI 79
XTALbg smart00247
Beta/gamma crystallins; Beta/gamma crystallins
1264-1344 6.42e-15

Beta/gamma crystallins; Beta/gamma crystallins


Pssm-ID: 214583  Cd Length: 82  Bit Score: 71.39  E-value: 6.42e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198   1264 VVLFEAMDFEGHGVEVSKALPDVELVQHGPSTQAIHVLSGVWVAYQEVGFSGEQYVLEKGVYRNCEDWGAGNSTLASLQP 1343
Cdd:smart00247    2 ITLYEDENFQGRSYELSDDCPSLQDYGSRDNVSSVRVESGCWVLYEQPNYRGRQYVLEPGEYPDYQEWGGFNDQISSIRR 81

                    .
gi 530361198   1344 V 1344
Cdd:smart00247   82 I 82
PHA03247 PHA03247
large tegument protein UL36; Provisional
248-710 1.86e-11

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 69.58  E-value: 1.86e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  248 PPASHLPRPTagGPRSTGLGSTVGAALRqlPETGTAELKDSSALASTGIPASAhlpknqdAPAACPDRDQGRAPDARACE 327
Cdd:PHA03247 2569 PPPRPAPRPS--EPAVTSRARRPDAPPQ--SARPRAPVDDRGDPRGPAPPSPL-------PPDTHAPDPPPPSPSPAANE 2637
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  328 LwqvlGAPSSTELPLQTSQGQASVPSSPRLETHVPSPG-LTHPAKQPVVPTHPGAR-----LTPLVLPPKKKDGPVDPPA 401
Cdd:PHA03247 2638 P----DPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGrAAQASSPPQRPRRRAARptvgsLTSLADPPPPPPTPEPAPH 2713
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  402 ATVlpmvrsehvTVPGQPPAPSTTRRKDVPSPGGLSAPSSPRNKFVQNSENVPVLPFTqrevVKGPGAPA-----ASSPT 476
Cdd:PHA03247 2714 ALV---------SATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPT----TAGPPAPAppaapAAGPP 2780
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  477 RKEVVQGSSASAASSPTwKEVVKGPGAPAASSPTQKEVVQGSSAPAALFPTWKEVVKGPGAPDASFPTWKEVVKG---PG 553
Cdd:PHA03247 2781 RRLTRPAVASLSESRES-LPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGsvaPG 2859
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  554 APAASSPTQKEVVQGSGAPA--ALSTTPKEVVKGPGAPAASSPTQKEVVKGPCAPAASSPTQKEVVQGSGAPA----ALS 627
Cdd:PHA03247 2860 GDVRRRPPSRSPAAKPAAPArpPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPppppPRP 2939
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  628 PKSTEVVQGPKGSSSIQKEAVQGIAGSLAPPLTKEETVQGPiAPATSLPKQDKGVQDSEGSPISSLTQ--KEVVQDPDAL 705
Cdd:PHA03247 2940 QPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVP-QPAPSREAPASSTPPLTGHSLSRVSSwaSSLALHEETD 3018

                  ....*
gi 530361198  706 PAPSS 710
Cdd:PHA03247 3019 PPPVS 3023
XTALbg smart00247
Beta/gamma crystallins; Beta/gamma crystallins
987-1066 7.71e-11

Beta/gamma crystallins; Beta/gamma crystallins


Pssm-ID: 214583  Cd Length: 82  Bit Score: 59.83  E-value: 7.71e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198    987 KVIFFSESGCQGSGREVWGD---IVDASGWAPVASIRVVRGCWVLYEEPEFRGQKLVLPEGdmELRTPGTkWSPQG--IG 1061
Cdd:smart00247    1 KITLYEDENFQGRSYELSDDcpsLQDYGSRDNVSSVRVESGCWVLYEQPNYRGRQYVLEPG--EYPDYQE-WGGFNdqIS 77

                    ....*
gi 530361198   1062 SLRRV 1066
Cdd:smart00247   78 SIRRI 82
beta-trefoil_Ricin_SCDase cd23456
ricin B-type lectin domain, beta-trefoil fold, found in Shewanella algae sphingolipid ceramide ...
1530-1656 2.15e-10

ricin B-type lectin domain, beta-trefoil fold, found in Shewanella algae sphingolipid ceramide N-deacylase (SCDase) and similar proteins; SCDase (EC 3.5.1.69) is an enzyme which hydrolyzes the N-acyl linkage between fatty acid and sphingosine in ceramide of various glycosphingolipids and sphingomyelin. Shewanella algae SCDase contains two ricin B-type lectin domains at its C-terminus. The ricin B-type lectin domain shows a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain may harbor a sugar-binding pocket.


Pssm-ID: 467334 [Multi-domain]  Cd Length: 122  Bit Score: 59.68  E-value: 2.15e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198 1530 YFRLWNAALGGFLAVPDHVedMKAGRVVVADPQAGGSCIWYYE-DGLLKNQMAPTMSLQVIGPPSPGSKVVLWAESRLPR 1608
Cdd:cd23456     2 YFQLKSQASGLCLDVSGGA--TNGANVVVYDCNNSNSQKWYYDaTGRLHSKANPGKCLDAGGENSNGANVVLWACNDSAN 79
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 530361198 1609 QTWSIsESGHICSQMFEGQILDVKGGRGydrDHVVLWEPDEDrASQIW 1656
Cdd:cd23456    80 QRWDF-DGNFIRSRNNTNLALDAYGSQG---SNVGLWQFHGG-ANQQW 122
PHA03247 PHA03247
large tegument protein UL36; Provisional
350-866 5.47e-10

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 64.96  E-value: 5.47e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  350 SVPSsPRLETHVPSPGLTHPAKQPVVPTHPGARLTPL-----------VLPPKKKDGPVDPPAATvlPMVRSEHVTVPGQ 418
Cdd:PHA03247 2567 SVPP-PRPAPRPSEPAVTSRARRPDAPPQSARPRAPVddrgdprgpapPSPLPPDTHAPDPPPPS--PSPAANEPDPHPP 2643
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  419 PPAPSTTRRKDVPSPGGLSAPSSPRNKFVQNSENVPVlpftqrevvKGPGAPAASSPTRKEVVQGSSASAASSPtwkEVV 498
Cdd:PHA03247 2644 PTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPP---------QRPRRRAARPTVGSLTSLADPPPPPPTP---EPA 2711
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  499 KGPGAPAASSPTQKEVVQGSSAPAALFPTWKEVVKGPGAPDAsfPTWKEVVKGPGAPAASSPTQKEVvqgsGAPAALSTT 578
Cdd:PHA03247 2712 PHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGG--PARPARPPTTAGPPAPAPPAAPA----AGPPRRLTR 2785
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  579 PKEVVKGPGAPAASSPtqkevvKGPCAPAASSPTQKEVVQGSGAPAALSPKSTEVVQGPKGSSSIQKEAVQGIAGSLAP- 657
Cdd:PHA03247 2786 PAVASLSESRESLPSP------WDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPg 2859
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  658 -PLTKEETVQGPIAPATSLPKqdkgvqdsegSPISSLTQKEVVQDPDALPAPSSSVDRvSPSPGGTPAPVPTGAEASTES 736
Cdd:PHA03247 2860 gDVRRRPPSRSPAAKPAAPAR----------PPVRRLARPAVSRSTESFALPPDQPER-PPQPQAPPPPQPQPQPPPPPQ 2928
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  737 QLVSDPTEGKtctetsreedevalaadleifldtlrsmePPEilrthrlPRAPRSSYLSMYATLPAIEEDQLGPWVlgPG 816
Cdd:PHA03247 2929 PQPPPPPPPR-----------------------------PQP-------PLAPTTDPAGAGEPSGAVPQPWLGALV--PG 2970
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|
gi 530361198  817 PQEVPsleekeeeeeeepenpylsddeklqrRQEKAGPSPSRDLhPARPT 866
Cdd:PHA03247 2971 RVAVP--------------------------RFRVPQPAPSREA-PASST 2993
XTALbg smart00247
Beta/gamma crystallins; Beta/gamma crystallins
1075-1155 6.93e-10

Beta/gamma crystallins; Beta/gamma crystallins


Pssm-ID: 214583  Cd Length: 82  Bit Score: 57.13  E-value: 6.93e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198   1075 ISLFSEEGLKGEQVKLTEALKNSQGLEKPLQVASATVSAGLWLLYPKPLFEDTPYILEPGEYPTSEAWGTSDPSVGSLKP 1154
Cdd:smart00247    2 ITLYEDENFQGRSYELSDDCPSLQDYGSRDNVSSVRVESGCWVLYEQPNYRGRQYVLEPGEYPDYQEWGGFNDQISSIRR 81

                    .
gi 530361198   1155 M 1155
Cdd:smart00247   82 I 82
PHA03247 PHA03247
large tegument protein UL36; Provisional
103-742 6.59e-09

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 61.11  E-value: 6.59e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  103 PPPkekRPEGRLKEAVDQS-DGSRQAPRTEPPCVGAMARTELLVPLPG-PREPsphpgvgltsgssrsleeyrvtrtvrt 180
Cdd:PHA03247 2552 PPP---LPPAAPPAAPDRSvPPPRPAPRPSEPAVTSRARRPDAPPQSArPRAP--------------------------- 2601
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  181 ttvvgghVDRRMSSSVTVRPVSsgealprgrqvsrmvppvvvgsppgspsrsqavkvlsnlvpaghSPPASHLPRPTAGG 260
Cdd:PHA03247 2602 -------VDDRGDPRGPAPPSP--------------------------------------------LPPDTHAPDPPPPS 2630
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  261 PRSTGlgstvgaalRQLPETGTAELKDSSALASTGIPASAHLPKNQdapaacpdRDQGRAPDARA-CELWQVLGAPSSTe 339
Cdd:PHA03247 2631 PSPAA---------NEPDPHPPPTVPPPERPRDDPAPGRVSRPRRA--------RRLGRAAQASSpPQRPRRRAARPTV- 2692
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  340 lplqtsqgqASVPSSPRLETHVPSPGLTHPAKQPVVPTHPGARLTPLVLPPKKKD-GPVDPPAATVLPMVrsehVTVPGQ 418
Cdd:PHA03247 2693 ---------GSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAApAPPAVPAGPATPGG----PARPAR 2759
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  419 PPAPSTTRRKDVPS-PGGLSAPSSPRNKFVQNSENVPVLPFTqrevvKGPGAPAASSPTRKEVVQGSSASAASSPTWKEV 497
Cdd:PHA03247 2760 PPTTAGPPAPAPPAaPAAGPPRRLTRPAVASLSESRESLPSP-----WDPADPPAAVLAPAAALPPAASPAGPLPPPTSA 2834
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  498 VKGPGAPAASSPTQKEVVQGSSAPAALF---PTWKEVVKGPGAP----------------DASFPTWKEVVKGPGAPAAS 558
Cdd:PHA03247 2835 QPTAPPPPPGPPPPSLPLGGSVAPGGDVrrrPPSRSPAAKPAAParppvrrlarpavsrsTESFALPPDQPERPPQPQAP 2914
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  559 SPTQKevvQGSGAPAALSTTPKEVVKGPGAPAAssPTQKEVVKGPCAPAASSPTQKEVVQGS-GAPAALSPKSTEVVQGP 637
Cdd:PHA03247 2915 PPPQP---QPQPPPPPQPQPPPPPPPRPQPPLA--PTTDPAGAGEPSGAVPQPWLGALVPGRvAVPRFRVPQPAPSREAP 2989
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  638 KGSSSIQKE----AVQGIAGSLApplTKEETVQGPIAPATSLPKQDKGVQDSEGSPISSLTQKEVVQDPDALPAPSSSVD 713
Cdd:PHA03247 2990 ASSTPPLTGhslsRVSSWASSLA---LHEETDPPPVSLKQTLWPPDDTEDSDADSLFDSDSERSDLEALDPLPPEPHDPF 3066
                         650       660
                  ....*....|....*....|....*....
gi 530361198  714 RVSPSPgGTPApvpTGAEASTESQLVSDP 742
Cdd:PHA03247 3067 AHEPDP-ATPE---AGARESPSSQFGPPP 3091
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
293-742 1.28e-07

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 56.85  E-value: 1.28e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198   293 STGIPASAHLPKNQDAPAACpdrdqgrAPdaracelwQVLGAPSSTELPLQTSQGQASVPSSPRLE---THVPSPGLTHP 369
Cdd:pfam05109  445 TTGLPSSTHVPTNLTAPAST-------GP--------TVSTADVTSPTPAGTTSGASPVTPSPSPRdngTESKAPDMTSP 509
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198   370 AKQPVVPTHPGARLTPLVLPPKKKdgPVDPPAATVLPmvrSEHVTVPgQPPAPSTTRRKDVPSPgglsapssprnkfvqn 449
Cdd:pfam05109  510 TSAVTTPTPNATSPTPAVTTPTPN--ATSPTLGKTSP---TSAVTTP-TPNATSPTPAVTTPTP---------------- 567
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198   450 SENVPVLPFTQREVVKGPGAPAASSPTRKEVV--QGSSASAASSPTWKEVVKGPGAPAASSPT--QKEVVQGSSAPAALF 525
Cdd:pfam05109  568 NATIPTLGKTSPTSAVTTPTPNATSPTVGETSpqANTTNHTLGGTSSTPVVTSPPKNATSAVTtgQHNITSSSTSSMSLR 647
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198   526 PTWKEVVKGPGAPDASfptwkeVVKGPGAPAASSPTQKEVVQGSGApaalSTTPKEVVKGPGAPAASSPTQkevVKGPCA 605
Cdd:pfam05109  648 PSSISETLSPSTSDNS------TSHMPLLTSAHPTGGENITQVTPA----STSTHHVSTSSPAPRPGTTSQ---ASGPGN 714
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198   606 PAASS-PTQKEVVQGSGAPAALSPkstevvQGPKGsssiQKEAVQGI--AGSLAPPLTKEETVQGPIAPATSLPKQDKGV 682
Cdd:pfam05109  715 SSTSTkPGEVNVTKGTPPKNATSP------QAPSG----QKTAVPTVtsTGGKANSTTGGKHTTGHGARTSTEPTTDYGG 784
                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198   683 qdsegspiSSLTQKEVVQDPDALPAPSSSvdRVSPSPGGTPAPVPTgAEASTESQLVSDP 742
Cdd:pfam05109  785 --------DSTTPRTRYNATTYLPPSTSS--KLRPRWTFTSPPVTT-AQATVPVPPTSQP 833
PHA03247 PHA03247
large tegument protein UL36; Provisional
331-866 1.44e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 56.87  E-value: 1.44e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  331 VLGAPSSTEL---------PLQTSQGQASVPSSPRletHVPSPGLTHPaKQPVVPTHPGaRLTPLVLPPKKKDGPVDPPA 401
Cdd:PHA03247 2459 ILGAPFSLSLllgelfpgaPVYRRPAEARFPFAAG---AAPDPGGGGP-PDPDAPPAPS-RLAPAILPDEPVGEPVHPRM 2533
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  402 ATVLPMVRSEHVTVPGQPP------APSTTRRKDVPSPGGLSAPSSPRNKFVQNSENVPVLPFTQREVVKGPGAPAASSP 475
Cdd:PHA03247 2534 LTWIRGLEELASDDAGDPPpplppaAPPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAP 2613
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  476 trkevvqgssasaaSSPTWKEVVKGPGAPAASSPTQKEVVQGSSAPAalfPTWKEVVKGPGAPDASFPtwKEVVKGPGAP 555
Cdd:PHA03247 2614 --------------PSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTV---PPPERPRDDPAPGRVSRP--RRARRLGRAA 2674
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  556 AASSPTQKEVVQGSGAPAAlSTTPKEVVKGPGAPAASSPTqkevvkgPCAPAASSPTQKEVVQGSGAPAALSPKSTEVVQ 635
Cdd:PHA03247 2675 QASSPPQRPRRRAARPTVG-SLTSLADPPPPPPTPEPAPH-------ALVSATPLPPGPAAARQASPALPAAPAPPAVPA 2746
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  636 GPKGSSSIQKEAvqgiagslAPPLTkeetvQGPIAPATSlpkqdkgvQDSEGSPISSLTQKEVV---QDPDALPAPSSSV 712
Cdd:PHA03247 2747 GPATPGGPARPA--------RPPTT-----AGPPAPAPP--------AAPAAGPPRRLTRPAVAslsESRESLPSPWDPA 2805
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  713 DRVSPSPGGTPAPVPTGAEAS-----TESQLVSDPTEGKTCTETSREEDEVALAADLEifldtlRSMEPPEILRTHRLPR 787
Cdd:PHA03247 2806 DPPAAVLAPAAALPPAASPAGplpppTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVR------RRPPSRSPAAKPAAPA 2879
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 530361198  788 APRSSYLSMYATLPAIEEDQLGPwvLGPGPQEVPSLEEKeeeeeeepenPYLSDDEKLQRRQEKAGPSPSRDLHPARPT 866
Cdd:PHA03247 2880 RPPVRRLARPAVSRSTESFALPP--DQPERPPQPQAPPP----------PQPQPQPPPPPQPQPPPPPPPRPQPPLAPT 2946
beta-trefoil_Ricin-like cd00161
ricin B-type lectin domain, beta-trefoil fold; The ricin B-type lectin domain is a ...
1530-1656 2.04e-06

ricin B-type lectin domain, beta-trefoil fold; The ricin B-type lectin domain is a carbohydrate-binding domain formed from presumed gene triplication. It shows a beta-trefoil fold characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. The ricin B-type lectin domain was originally found in Ricin, which is a legume lectin from the seeds of the castor bean plant, Ricinus communis. It is also found in many carbohydrate-recognition proteins like plant and bacterial AB-toxins, glycosidases, or proteases, which serve diverse functions such as inhibitory toxicity, enzymatic activity, and signal transduction. The ricin B-type lectin domain can be present in one or more copies and has been shown in some instances to bind simple sugars, such as galactose or lactose. The most characteristic, though not completely conserved, sequence feature is the presence of a Q-W pattern. Consequently, the ricin B-type lectin domain has also been referred as the (QxW)3 domain and the three homologous regions as the QxW repeats. A disulfide bond is also conserved in some QxW repeats.


Pssm-ID: 467293 [Multi-domain]  Cd Length: 134  Bit Score: 48.91  E-value: 2.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198 1530 YFRLWNAALGGFLAVPDHveDMKAG-RVVVADPQAGGSCIWYYED-----GLLKNqMAPTMSLQVIG-PPSPGSKVVLWA 1602
Cdd:cd00161     2 TYRIVNAASGKCLDVAGG--STANGaPVQQWTCNGGANQQWTLTPvgdgyYTIRN-VASGKCLDVAGgSTANGANVQQWT 78
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 530361198 1603 ESRLPRQTWSISESG----HICSQMfEGQILDVKGGRGYDRDHVVLWePDEDRASQIW 1656
Cdd:cd00161    79 CNGGDNQQWRLEPVGdgyyRIVNKH-SGKCLDVSGGSTANGANVQQW-TCNGGANQQW 134
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
261-767 2.55e-06

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 52.30  E-value: 2.55e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  261 PRSTGLGSTVGAAL----RQLPETGTAELKDSSALASTGIPASAHLPKNQDAPAAcpdrDQGRAPDARAcelwqvlgAPS 336
Cdd:PRK07764  365 PSASDDERGLLARLerleRRLGVAGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAA----AAAPAPAAAP--------QPA 432
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  337 STELPLQTSQGQASVPSSPRLETHVPSPGLT-HPAKQPVVPTHPGARLTPLVLPPKKKDGPVDPPAATVLPMVRSEHVTV 415
Cdd:PRK07764  433 PAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSaQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAGADDAATL 512
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  416 PGQPPAPSTTRRKDVPSPGGLSAPssprnkfvqnseNVPVLPFTQREVV----KGPGAPAASSPTRKEVVQGSSASAASS 491
Cdd:PRK07764  513 RERWPEILAAVPKRSRKTWAILLP------------EATVLGVRGDTLVlgfsTGGLARRFASPGNAEVLVTALAEELGG 580
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  492 pTWK-EVVKGPGAPAASSPTQKEVVQGSSAPAALFPTwkevvkgpgAPDAsfptwkevvkgPGAPAASSPTqkevvQGSG 570
Cdd:PRK07764  581 -DWQvEAVVGPAPGAAGGEGPPAPASSGPPEEAARPA---------APAA-----------PAAPAAPAPA-----GAAA 634
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  571 APAALSTTpkevvkgPGAPAASSPTQKEVVKGPCAPAASSPTQKEVvqGSGAPAALSPKSTEVVQGPKGSSSiqkeavqg 650
Cdd:PRK07764  635 APAEASAA-------PAPGVAAPEHHPKHVAVPDASDGGDGWPAKA--GGAAPAAPPPAPAPAAPAAPAGAA-------- 697
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  651 iAGSLAPPLTKEETVQGPIAPATSLPKQDKG-VQDSEGSPISSLTQKEVVQDPDALPAPSSSVDRVSPSPGGTPAPVPTG 729
Cdd:PRK07764  698 -PAQPAPAPAATPPAGQADDPAAQPPQAAQGaSAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPP 776
                         490       500       510
                  ....*....|....*....|....*....|....*...
gi 530361198  730 AEASTESQLVSDPTEGkTCTETSREEDEVALAADLEIF 767
Cdd:PRK07764  777 SPPSEEEEMAEDDAPS-MDDEDRRDAEEVAMELLEEEL 813
Ricin_B_lectin pfam00652
Ricin-type beta-trefoil lectin domain;
1569-1656 5.97e-06

Ricin-type beta-trefoil lectin domain;


Pssm-ID: 395527 [Multi-domain]  Cd Length: 126  Bit Score: 47.14  E-value: 5.97e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  1569 W-YYEDGLLKNqMAPTMSLQVIGPpSPGSKVVLWA-ESRLPRQTWSISESGHICSQMFEGQILDVKGGrGYDRDHVVLWE 1646
Cdd:pfam00652   40 WtLTGDGTIRS-VASDLCLDVGST-ADGAKVVLWPcHPGNGNQRWRYDEDGTQIRNPQSGKCLDVSGA-GTSNGKVILWT 116
                           90
                   ....*....|
gi 530361198  1647 PDEDRASQIW 1656
Cdd:pfam00652  117 CDSGNPNQQW 126
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
307-742 7.95e-06

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 50.94  E-value: 7.95e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  307 DAPAACPDRDQGRAPDARACeLWQVLGAPSSTELPLQTSQGQASVPSSPRLETHVPSPGLTHPAKQPvvPTHPGARLTPL 386
Cdd:PHA03307   47 SAELAAVTVVAGAAACDRFE-PPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPS--SPDPPPPTPPP 123
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  387 VLPPKkkdgPVDPPAATVLPMVRSeHVTVPGQPPAPSTTRRKDVPSPGGLSAPSSPRNKFVQNSENVPVLPFTQREVVKG 466
Cdd:PHA03307  124 ASPPP----SPAPDLSEMLRPVGS-PGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTP 198
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  467 PGAPAASSPTRKEVVQGSSASAASSPTwkevvKGPGAPAASSPTqkevvqGSSAPAALFPTWKEVVKGPGAPDASF--PT 544
Cdd:PHA03307  199 PAAASPRPPRRSSPISASASSPAPAPG-----RSAADDAGASSS------DSSSSESSGCGWGPENECPLPRPAPItlPT 267
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  545 WKEVVKGPGAPAASSPTQKEvvqgSGAPAALSTTPKEVVKGPGAPAASSPTQKEVVKGPCAPAASSPTQKEVVQGSGAPA 624
Cdd:PHA03307  268 RIWEASGWNGPSSRPGPASS----SSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSP 343
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  625 ALSPKStevvqGPKGSSSiqkeavqgiAGSLAPPLTKEETVQGPIAPATSLPKqdkgvqdseGSPISSLTQKevvqdpdA 704
Cdd:PHA03307  344 GPSPSR-----SPSPSRP---------PPPADPSSPRKRPRPSRAPSSPAASA---------GRPTRRRARA-------A 393
                         410       420       430
                  ....*....|....*....|....*....|....*...
gi 530361198  705 LPAPSSSVDRVSPSPGGTPAPVPTGAEASTESQLVSDP 742
Cdd:PHA03307  394 VAGRARRRDATGRFPAGRPRPSPLDAGAASGAFYARYP 431
PHA03378 PHA03378
EBNA-3B; Provisional
248-624 1.29e-05

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 50.07  E-value: 1.29e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  248 PPASHLPRPTAGGP---------RSTGLGSTVGAALRQLPETGTAELK------DSSALASTGIPASAHLPKNQDAPAAC 312
Cdd:PHA03378  526 PPSPPQPRAGRRAPcvytedldiESDEPASTEPVHDQLLPAPGLGPLQiqpltsPTTSQLASSAPSYAQTPWPVPHPSQT 605
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  313 PD--RDQGRAPDARACELWQVLGAPSSTElPLQTSQGQASVP------SSPRLETHVPSPGLTHPAKQPVVPTHPGARLT 384
Cdd:PHA03378  606 PEppTTQSHIPETSAPRQWPMPLRPIPMR-PLRMQPITFNVLvfptphQPPQVEITPYKPTWTQIGHIPYQPSPTGANTM 684
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  385 plvLPPKKKDGPVDPPAATVLPMVRSEHVTVPGQPPAPSTTRRKD-------VPSPGGLSAPSSPRNKFVQNSENVPVLP 457
Cdd:PHA03378  685 ---LPIQWAPGTMQPPPRAPTPMRPPAAPPGRAQRPAAATGRARPpaaapgrARPPAAAPGRARPPAAAPGRARPPAAAP 761
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  458 FTQREVVKGPGAPAASSPTRKEVVQGSSASAASSPTWKE-------VVKGPGAPAASSPTQKEVVQG------SSAPAAL 524
Cdd:PHA03378  762 GRARPPAAAPGAPTPQPPPQAPPAPQQRPRGAPTPQPPPqagptsmQLMPRAAPGQQGPTKQILRQLltggvkRGRPSLK 841
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  525 FPTWKEVVKGPG-APDASFPTWKEVVKGP-GAPAASSPTQKEVVQGSGAPAALSTTPKEVVKGPGAPAASSPTQKEVVKG 602
Cdd:PHA03378  842 KPAALERQAAAGpTPSPGSGTSDKIVQAPvFYPPVLQPIQVMRQLGSVRAAAASTVTQAPTEYTGERRGVGPMHPTDIPP 921
                         410       420
                  ....*....|....*....|..
gi 530361198  603 PCAPAASSPTQKEVVQGSGAPA 624
Cdd:PHA03378  922 SKRAKTDAYVESQPPHGGQSHS 943
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
473-743 2.46e-05

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 49.14  E-value: 2.46e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198   473 SSPTRKEVVQGSSASAASSPTWKEVVKGPGAPAASSPTQKEVVQGSSAPAALFPTWKEVVKGPG---------APDASFP 543
Cdd:pfam05109  430 TSPTLNTTGFAAPNTTTGLPSSTHVPTNLTAPASTGPTVSTADVTSPTPAGTTSGASPVTPSPSprdngteskAPDMTSP 509
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198   544 TWKEVVKGPGA----PAASSPTQKevvqgSGAPAALSTTPKEVVKGPgAPAASSPTqkevvkgpcaPAASSPTQKEVVQG 619
Cdd:pfam05109  510 TSAVTTPTPNAtsptPAVTTPTPN-----ATSPTLGKTSPTSAVTTP-TPNATSPT----------PAVTTPTPNATIPT 573
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198   620 SGAPaalSPKSTEVVQGPKGSSSiqkeavqgIAGSLAPPL-TKEETVQGPIAP--ATSLPKQDKGVQDSEGSPISSLTQK 696
Cdd:pfam05109  574 LGKT---SPTSAVTTPTPNATSP--------TVGETSPQAnTTNHTLGGTSSTpvVTSPPKNATSAVTTGQHNITSSSTS 642
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|
gi 530361198   697 EVVQDPDALP---APSSSVDRVSPSPGGTPAPvPTGAEASTESQLVSDPT 743
Cdd:pfam05109  643 SMSLRPSSISetlSPSTSDNSTSHMPLLTSAH-PTGGENITQVTPASTST 691
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
369-594 4.34e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 48.33  E-value: 4.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  369 PAKQPVVPTHPGARLTPLVLPPKKKDGPVDPPAATVLPMVRSEHVTVPGQ-PPAP---STTRRKDVPSPGGLSAPSSprn 444
Cdd:PRK12323  376 TAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARrSPAPealAAARQASARGPGGAPAPAP--- 452
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  445 kfvqNSENVPVlpftqrevvkGPGAPAASSPtrkevvqgssasaassptwkevvKGPGAPAASSPTQKEVVQGSSAPAAL 524
Cdd:PRK12323  453 ----APAAAPA----------AAARPAAAGP-----------------------RPVAAAAAAAPARAAPAAAPAPADDD 495
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530361198  525 FPTWKEV-----VKGPGAPDASFPTW-KEVVKGPGAPAASSPTQKEVVQGSGAPAALSTTPKEVVKGPGAPAASSP 594
Cdd:PRK12323  496 PPPWEELppefaSPAPAQPDAAPAGWvAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASAS 571
beta-trefoil_Ricin_SCDase_rpt1 cd23499
first ricin B-type lectin domain, beta-trefoil fold, found in Shewanella algae sphingolipid ...
1530-1656 7.25e-05

first ricin B-type lectin domain, beta-trefoil fold, found in Shewanella algae sphingolipid ceramide N-deacylase (SCDase) and similar proteins; SCDase (EC 3.5.1.69) is an enzyme which hydrolyzes the N-acyl linkage between fatty acid and sphingosine in ceramide of various glycosphingolipids and sphingomyelin. Shewanella algae SCDase contains two ricin B-type lectin domains at its C-terminus. The ricin B-type lectin domain shows a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain may harbor a sugar-binding pocket. The model corresponds to the first lectin domain.


Pssm-ID: 467377 [Multi-domain]  Cd Length: 131  Bit Score: 44.36  E-value: 7.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198 1530 YFRLWNAALGGFLAVPDHVEDMKAGRVVVADPQAGGSCI--WYY--EDGLLKNQMAPTMSLQVIGPPSPGSKVVLWAESR 1605
Cdd:cd23499     2 FVRIVNRASGKCLDIPGNDNDVVNGANVILWDCADKSADqrWIYdaASGMLRNKANPSYCLDNRGQAYNGGEVVLWQCED 81
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 530361198 1606 LPRQTWSISeSGHICSQMFEGQILDVkGGRGYDrDHVVLWEpDEDRASQIW 1656
Cdd:cd23499    82 SDNLRWTYD-NGVLRSKHNPNIVLDA-YGRDNN-SQVGQWE-YHGGANQQW 128
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
500-766 8.20e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 47.56  E-value: 8.20e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  500 GPGAPAASSPTQKEVVQGSSAPAALFPTWKEVVKGPGAPDASFPTWKEVVkgpGAPAASSPtqkevvqgsgAPAALSTTP 579
Cdd:PRK12323  371 GAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVA---AAPARRSP----------APEALAAAR 437
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  580 KEVVKGPGAPAASSPTQkevvkgPCAPAASSPTQKEVVQGSGAPAALSPksteVVQGPKGSSSIQKEAVqgiagslaPPL 659
Cdd:PRK12323  438 QASARGPGGAPAPAPAP------AAAPAAAARPAAAGPRPVAAAAAAAP----ARAAPAAAPAPADDDP--------PPW 499
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  660 tkEETvqGPIAPATSLPKQDKGVQDSEGSPISsltqKEVVQDPDAlpapsssvDRVSPSPGGTPAPVPTGAEASTESQLV 739
Cdd:PRK12323  500 --EEL--PPEFASPAPAQPDAAPAGWVAESIP----DPATADPDD--------AFETLAPAPAAAPAPRAAAATEPVVAP 563
                         250       260
                  ....*....|....*....|....*..
gi 530361198  740 SDPTEGKTCTETSREEDEVALAADLEI 766
Cdd:PRK12323  564 RPPRASASGLPDMFDGDWPALAARLPV 590
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
362-603 8.71e-05

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 47.38  E-value: 8.71e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  362 PSPGLTH-PAKQPVVPTHPGArltplvlpPKKKDGPVDP--PAATVLPMVRSEhvtvPGQPPAPSTTRRKDVP-SPGGLS 437
Cdd:PTZ00449  561 PGPAKEHkPSKIPTLSKKPEF--------PKDPKHPKDPeePKKPKRPRSAQR----PTRPKSPKLPELLDIPkSPKRPE 628
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  438 APSSPRNkfvqnsenvPVLPftQRevvkgpgapaASSPTRKEvvqgssasaasSPTWKEVVKGPGAPAAS-SPTQKEVVQ 516
Cdd:PTZ00449  629 SPKSPKR---------PPPP--QR----------PSSPERPE-----------GPKIIKSPKPPKSPKPPfDPKFKEKFY 676
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  517 GSSAPAAlfPTWKEVVKGPGAPDASFPTWKEVVkgPGAPAASSPTQKEVvqgsgaPAALSTTPKEVVKGPGAPAASSPTQ 596
Cdd:PTZ00449  677 DDYLDAA--AKSKETKTTVVLDESFESILKETL--PETPGTPFTTPRPL------PPKLPRDEEFPFEPIGDPDAEQPDD 746

                  ....*..
gi 530361198  597 KEVVKGP 603
Cdd:PTZ00449  747 IEFFTPP 753
beta-trefoil_Ricin_GllA-1 cd23454
GllA-1 domain, beta-trefoil fold, found in Mucor circinelloides Gellins and similar proteins; ...
1555-1658 9.04e-05

GllA-1 domain, beta-trefoil fold, found in Mucor circinelloides Gellins and similar proteins; Gellin proteins act as central effectors of wound-induced protoplasmic gelation. They possess ten related N-terminal beta-trefoil domains (Gll-1 to Gll-10) that contribute to distinct gelation-related activities. The beta-trefoil domains show low sequence similarity to members of the functionally diverse ricin B lectin domain family. They are characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain bears a potential sugar binding site. Gellin from M. circinelloides has been called GellinA (also known as GllA). The model corresponds to GllA-1 domain, which is a remote family member of the ricin B-type lectin domain.


Pssm-ID: 467332 [Multi-domain]  Cd Length: 136  Bit Score: 44.23  E-value: 9.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198 1555 RVVVAD--PQAGGSCIWYYEDGLLKNQMaptmSLQVI----GPPSPGSKVVLWAESRLPR---QTWSISESGHICSQMFE 1625
Cdd:cd23454    26 KVVLAPlkTKDYESQLWRYDDGYLVNKA----SGLVLdiqgGVVKSGTRLVQSPKKPSKDannQRWGLTADGYIYLLSNP 101
                          90       100       110
                  ....*....|....*....|....*....|....*
gi 530361198 1626 GQILDVKGGRGYDRDHVVLWE--PDEDRASQIWTI 1658
Cdd:cd23454   102 SLVLGIKGNETREGARVILQErkLQKDALNQRWTF 136
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
532-733 1.19e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 47.15  E-value: 1.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  532 VKGPGAPDASFPTwkEVVKGPGAPAASSPTQKEVVQGSGAPAALSTTPKEVVKGPGAPAASSPTQKEVVKGPCAPAASSP 611
Cdd:PRK07003  362 VTGGGAPGGGVPA--RVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRG 439
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  612 TQKEVVQGSGAPAALSPKSTEVVQGPKGSSSIQKEAVQGIAGSLAPPLTKEEtvqgPIAPATSLPKQDKGVQDSEGSPIS 691
Cdd:PRK07003  440 DDAADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFE----PAPRAAAPSAATPAAVPDARAPAA 515
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 530361198  692 SLTQKEVVqdPDALPAPSSSvdrvSPSPG-GTPAPVPTGAEAS 733
Cdd:PRK07003  516 ASREDAPA--AAAPPAPEAR----PPTPAaAAPAARAGGAAAA 552
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
248-686 1.72e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 46.52  E-value: 1.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  248 PPASHLPRPTAGGPRSTGlgstVGAALRQLPETGTAELKDSSALASTGIPASAHLPKNQDAPAACPDRDQGRAPDARAce 327
Cdd:PRK07764  386 GVAGGAGAPAAAAPSAAA----AAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPA-- 459
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  328 lwqvlGAPSSTELPLQTSQGQASVPSSPRLETHVPSPGLTHPAKQPVVPTHPGARLTP------LVLPPKKKDGPVDP-- 399
Cdd:PRK07764  460 -----AAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAGADDAATLrerwpeILAAVPKRSRKTWAil 534
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  400 -PAATVLpMVRSEHVTVpgqppapsttrrkDVPSPGGLSAPSSPRN--KFVQNSENVPVLPFtQREVVKGPGAPAASSPT 476
Cdd:PRK07764  535 lPEATVL-GVRGDTLVL-------------GFSTGGLARRFASPGNaeVLVTALAEELGGDW-QVEAVVGPAPGAAGGEG 599
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  477 RKEVVQgssasaassPTWKEVVKGPGAPAASSPTQKEVVQGSSAPAALFPTWKE--------VVKGPGAPDASFPTWKEV 548
Cdd:PRK07764  600 PPAPAS---------SGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPApgvaapehHPKHVAVPDASDGGDGWP 670
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  549 VK-GPGAPAASSPTQKEVVQGSGAPAAlsttPKEVVKGPGAPAASSPTQKEVVKGPCAPAASSPTQKevVQGSGAPAALS 627
Cdd:PRK07764  671 AKaGGAAPAAPPPAPAPAAPAAPAGAA----PAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSP--AADDPVPLPPE 744
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 530361198  628 PKSTEVVQGPKGSSSIQKEAVQGIAGSLAPPLTKEETVQGPIAPATSlPKQDKGVQDSE 686
Cdd:PRK07764  745 PDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEMAEDDAP-SMDDEDRRDAE 802
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
433-726 2.06e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 46.00  E-value: 2.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  433 PGGLSAPSSPRNKFVQNSENVPVLPFTQREVVKGPGAPAASSPTRKEVVQGSSASAASSPtwkevvKGPGAPAASSPTQK 512
Cdd:PRK07003  368 PGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPP------AAPAPPATADRGDD 441
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  513 EVVQGSSAPAALfPTWKEVVKGPGAPDASFPTWKEVVKGPgAPAASSPTQKE------VVQGSGAPAALSTTPKEVVKGP 586
Cdd:PRK07003  442 AADGDAPVPAKA-NARASADSRCDERDAQPPADSGSASAP-ASDAPPDAAFEpapraaAPSAATPAAVPDARAPAAASRE 519
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  587 GAPAASSPTQKEVvkGPCAPAASSPTQKevvqGSGAPAAL-----------SPKSTEVVQGPK---GSSSIQKEAVQGIA 652
Cdd:PRK07003  520 DAPAAAAPPAPEA--RPPTPAAAAPAAR----AGGAAAALdvlrnagmrvsSDRGARAAAAAKpaaAPAAAPKPAAPRVA 593
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  653 GSLAPPLTKEETVQGPIAPATSLPKQdkgvQDSEGSP----------ISSLTQKEVVQDPDA--LPAPSSSVD--RVSPS 718
Cdd:PRK07003  594 VQVPTPRARAATGDAPPNGAARAEQA----AESRGAPppwedippddYVPLSADEGFGGPDDgfVPVFDSGPDdvRVAPK 669

                  ....*...
gi 530361198  719 PGGTPAPV 726
Cdd:PRK07003  670 PADAPAPP 677
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
466-674 7.28e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 44.48  E-value: 7.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  466 GPGAPAASSPTRKEVVQGSSASAASSPTWKEVVKGPGAPAASSPTQKEVVQG----SSAPAALFPTWKEVVKGPGAPDAS 541
Cdd:PRK12323  371 GAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAparrSPAPEALAAARQASARGPGGAPAP 450
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  542 FPTwkevvkgpgAPAASSPTQKEVVQGSGAPAALSTTPKEVVKGPGAPAASSPTQKEVVKGPCAPAASSPTQKEvvqGSG 621
Cdd:PRK12323  451 APA---------PAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPD---AAP 518
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 530361198  622 APAALSPKSTEVVQGPKGSSSIQKEAvqGIAGSLAPPLTKEETVQGPIAPATS 674
Cdd:PRK12323  519 AGWVAESIPDPATADPDDAFETLAPA--PAAAPAPRAAAATEPVVAPRPPRAS 569
PHA03379 PHA03379
EBNA-3A; Provisional
344-676 1.17e-03

EBNA-3A; Provisional


Pssm-ID: 223066 [Multi-domain]  Cd Length: 935  Bit Score: 43.89  E-value: 1.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  344 TSQGQASVPSSPrlETHVPSPGLTH--------PAKQ----PVVPTHPGARLTPLVLPPKKKDGPVDPPAATVLPMVRSE 411
Cdd:PHA03379  435 TSHGSAQVPEPP--PVHDLEPGPLHdqhsmapcPVAQlppgPLQDLEPGDQLPGVVQDGRPACAPVPAPAGPIVRPWEAS 512
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  412 HVTVPGQPPAPSttrrkdvpSPGGLSAPSSPRNKFVQNSenvPVLPFTQREVVKGPGAPAASSPTRKevvqgssasaass 491
Cdd:PHA03379  513 LSQVPGVAFAPV--------MPQPMPVEPVPVPTVALER---PVCPAPPLIAMQGPGETSGIVRVRE------------- 568
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  492 pTWKEVVKGPGAPAASSPTQ--------KEVVQGSSAPAALFPTwkEVVKGPGAPDASFPTWKEVVKGPGAPAASSPtqk 563
Cdd:PHA03379  569 -RWRPAPWTPNPPRSPSQMSvrdrlarlRAEAQPYQASVEVQPP--QLTQVSPQQPMEYPLEPEQQMFPGSPFSQVA--- 642
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  564 EVVQGSGAPA------ALSTTPKEVVKGPGAPAASSPTQKEVVKGPCAPAASSPTQKEVVQGSGAPAALSPKSTEVVQGP 637
Cdd:PHA03379  643 DVMRAGGVPAmqpqyfDLPLQQPISQGAPLAPLRASMGPVPPVPATQPQYFDIPLTEPINQGASAAHFLPQQPMEGPLVP 722
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 530361198  638 K----GSSSIQKEAVQGIAGS--LAPPLTKEETVQGPIAPATSLP 676
Cdd:PHA03379  723 ErwmfQGATLSQSVRPGVAQSqyFDLPLTQPINHGAPAAHFLHQP 767
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
296-678 1.41e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 43.60  E-value: 1.41e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198   296 IPASAHLPKNQDAPAACPDRDQGRAPDAracelwqvlGAPSSTELPLQTSQGQAS---VPSSPRLETH-VPSPgltHPAK 371
Cdd:pfam03154  182 SPPSPPPPGTTQAATAGPTPSAPSVPPQ---------GSPATSQPPNQTQSTAAPhtlIQQTPTLHPQrLPSP---HPPL 249
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198   372 QPVVPTHPGARLTPLVLPPKKKDGPVDPPAATVLPMVRSEHVTVPGQP-PAPSTTRRKDVPSPGGLSAPSSPRNKFVQ-N 449
Cdd:pfam03154  250 QPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPVPPQPfPLTPQSSQSQVPPGPSPAAPGQSQQRIHTpP 329
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198   450 SENVPVLPFTQREVVKGPGA---PAASSPTRKEVVQGSSASAASSPtwkevvkgpgaPAASSPTQKEVVQGSSAPAALFP 526
Cdd:pfam03154  330 SQSQLQSQQPPREQPLPPAPlsmPHIKPPPTTPIPQLPNPQSHKHP-----------PHLSGPSPFQMNSNLPPPPALKP 398
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198   527 TWKEVVKGPgaPDASFPTWKEVVKGPGAPaaSSPTQKEVV-QGSGAPAALSTTPKEVVKGPGAPAASSPTQKEVVKGPca 605
Cdd:pfam03154  399 LSSLSTHHP--PSAHPPPLQLMPQSQQLP--PPPAQPPVLtQSQSLPPPAASHPPTSGLHQVPSQSPFPQHPFVPGGP-- 472
                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 530361198   606 PAASSPtqkevvqgSGAPAALSPKSTEVVQGPKGSSSIQKEAVQGIAGSLAPPLTKEETVQGPIAPATSLPKQ 678
Cdd:pfam03154  473 PPITPP--------SGPPTSTSSAMPGIQPPSSASVSSSGPVPAAVSCPLPPVQIKEEALDEAEEPESPPPPP 537
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
551-672 2.07e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 42.78  E-value: 2.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  551 GPGAPAASSPTQKEVVQGSGAPAALSTTPKEVVKGPGAPAASSPTQKEVVKGPCAPAASSPTQKEVVQGSGAPAALSPKS 630
Cdd:PRK14951  370 AEAAAPAEKKTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAPAAVALAP 449
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 530361198  631 TEVVQGPKGSSSIQKEAVQGIAGSLAPPLTKEETVQGPIAPA 672
Cdd:PRK14951  450 APPAQAAPETVAIPVRVAPEPAVASAAPAPAAAPAAARLTPT 491
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
386-625 2.31e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 42.56  E-value: 2.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  386 LVLPPKKKDGPVDPPAATVLPMVRsehVTVPGQPPAPSTTRRKDVPSPGGLSAPSSPRNKFVQnsenvpvlpftqrevvk 465
Cdd:PRK12323  361 LAFRPGQSGGGAGPATAAAAPVAQ---PAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVA----------------- 420
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  466 gpGAPAASSPTRKEVvqgssasaasSPTWKEVVKGPGAPAASSPTQKEV-----------VQGSSAPAALFPTWKEVVKG 534
Cdd:PRK12323  421 --AAPARRSPAPEAL----------AAARQASARGPGGAPAPAPAPAAApaaaarpaaagPRPVAAAAAAAPARAAPAAA 488
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  535 PGAPDASFPTWKEVvkgPGAPAASSPTQKEvvqGSGAPAALSTTPKEvvkGPGAPAASSPTQKEVVKGPCAPAASSPTQK 614
Cdd:PRK12323  489 PAPADDDPPPWEEL---PPEFASPAPAQPD---AAPAGWVAESIPDP---ATADPDDAFETLAPAPAAAPAPRAAAATEP 559
                         250
                  ....*....|.
gi 530361198  615 EVVQGSGAPAA 625
Cdd:PRK12323  560 VVAPRPPRASA 570
DUF959 pfam06121
Domain of Unknown Function (DUF959); This N-terminal domain is not expressed in the 'Short' ...
498-612 2.36e-03

Domain of Unknown Function (DUF959); This N-terminal domain is not expressed in the 'Short' isoform of Collagen A.


Pssm-ID: 399255 [Multi-domain]  Cd Length: 192  Bit Score: 40.97  E-value: 2.36e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198   498 VKGPGAPAASSPTQKEVVQGSSAPAALFPTWKEVVKGPGAPdasfPTWKEVVKGPGAPAASSPTQKEVVQGSGAPAAL-- 575
Cdd:pfam06121   41 VQPAAAPATHVAPQDDPAEQATAAASPELPLEELEAAPGRA----PGAPISAAAPAALAARPDMREENVAGVGAKILNia 116
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 530361198   576 -----------STTPKEVVKGPGAPAASSPTQKEVVKGPCAPAASSPT 612
Cdd:pfam06121  117 qgiqsfiqlwnDAAPTESPAGAGTLAASAPTDPLALAEPSGPAAESGT 164
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
466-632 2.51e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 42.53  E-value: 2.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  466 GPGAPAASSPTRKEVVQGSSASAASSPTWKEVVKGPGAPAASSPTQKEVVQGSSAPAALFP------TWKEVVKGPGAPD 539
Cdd:PRK07003  367 APGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPaapappATADRGDDAADGD 446
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  540 ASFPTwKEVVKGPGAPAASSPTQKEVVQGSGAPAALSTTPKEVVKGPGAPAASSPTQKEVVKGPCAPAASSPTQKEV-VQ 618
Cdd:PRK07003  447 APVPA-KANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASREDAPaAA 525
                         170
                  ....*....|....
gi 530361198  619 GSGAPAALSPKSTE 632
Cdd:PRK07003  526 APPAPEARPPTPAA 539
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
396-737 2.73e-03

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 42.25  E-value: 2.73e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198   396 PVDPPAATVLPMVRSEHVTVPGQPPAPSTTRRKDVPSPGGLSAPSSPRNKFVQNSENVPVLPFTQREVVKGPGAPAASSP 475
Cdd:pfam17823  115 LAAAASSSPSSAAQSLPAAIAALPSEAFSAPRAAACRANASAAPRAAIAAASAPHAASPAPRTAASSTTAASSTTAASSA 194
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198   476 TRKEVVQGSSASAASSPTWKEVVkGPGAPAASSPTQKevvQGSSAPAalfptwkevvkgPGAPDASFPTWKEVVKGPGAP 555
Cdd:pfam17823  195 PTTAASSAPATLTPARGISTAAT-ATGHPAAGTALAA---VGNSSPA------------AGTVTAAVGTVTPAALATLAA 258
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198   556 AASSPTQKEVVQGSGAPAALSTTPKEVVKGPGAPAASSPTQKEVVKGPCAPAAsspTQKEVVQGSGAPAALSPKSTEVVQ 635
Cdd:pfam17823  259 AAGTVASAAGTINMGDPHARRLSPAKHMPSDTMARNPAAPMGAQAQGPIIQVS---TDQPVHNTAGEPTPSPSNTTLEPN 335
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198   636 GPKGSSSIQKEAVqgiagSLAPPLTKEETVQG-PIAPATSLPKQDKGVQDSEGSPISSlTQKevVQDPDALPAP------ 708
Cdd:pfam17823  336 TPKSVASTNLAVV-----TTTKAQAKEPSASPvPVLHTSMIPEVEATSPTTQPSPLLP-TQG--AAGPGILLAPeqvate 407
                          330       340       350
                   ....*....|....*....|....*....|...
gi 530361198   709 -SSSVDRVSPSP---GGTPAPVPTGAEASTESQ 737
Cdd:pfam17823  408 aTAGTASAGPTPrssGDPKTLAMASCQLSTQGQ 440
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
566-773 2.82e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 42.53  E-value: 2.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  566 VQGSGAPAALSttPKEVVKGPGAPAASSPTQKEVVKGPCAPAASSPTQKEVVQGSGAPAALSPKSTEVVQGPKGSSSIQK 645
Cdd:PRK07003  362 VTGGGAPGGGV--PARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRG 439
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  646 EAVQGIAGSLAPPLTKEETVQGPIAPATSLPKQDKGVQDSEGSPISSLTQKEvvqdpdalPAPSSSVDRVSPSPGGTPAP 725
Cdd:PRK07003  440 DDAADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFE--------PAPRAAAPSAATPAAVPDAR 511
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 530361198  726 VPTGAEASTESQLVSDPTEgKTCTETSREEDEVALAADLEIFLDTLRS 773
Cdd:PRK07003  512 APAAASREDAPAAAAPPAP-EARPPTPAAAAPAARAGGAAAALDVLRN 558
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
526-626 3.07e-03

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 42.57  E-value: 3.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  526 PTWKEV----VKGPGAPDASFPTWKEVVKGPGAPAASSPTQKEVVQGSGAPAALSTTPKEVVKGPGAPAASSPTQKEVVk 601
Cdd:PRK12270   27 PSWREFfadyGPGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPAAAAAAAAAPAAPPAAAAA- 105
                          90       100
                  ....*....|....*....|....*
gi 530361198  602 gpcAPAASSPTQKEVVQGSGAPAAL 626
Cdd:PRK12270  106 ---AAPAAAAVEDEVTPLRGAAAAV 127
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
498-737 5.56e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 41.37  E-value: 5.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  498 VKGPGAPAASSPTQkeVVQGSSAPAALFPTWKEVVKGPGAPDASFPTWKEVVKGPGAPAASSPTQKEVVQGSGAPAALST 577
Cdd:PRK07003  362 VTGGGAPGGGVPAR--VAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRG 439
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  578 TPKEVVKGPGAPAASSPTQKEVVKGPCA--PAASSPTQKEVVQGSGAPAALSPKSTEVVQGPKGSSSIQKEAVQGIA--G 653
Cdd:PRK07003  440 DDAADGDAPVPAKANARASADSRCDERDaqPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAAsrE 519
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530361198  654 SLAPPLTKEETVQGPIAPATSLPKQDKG-------VQDSEGSPISSltqkEVVQDPDALPAPSSSVDRVSPSPGGTPA-P 725
Cdd:PRK07003  520 DAPAAAAPPAPEARPPTPAAAAPAARAGgaaaaldVLRNAGMRVSS----DRGARAAAAAKPAAAPAAAPKPAAPRVAvQ 595
                         250
                  ....*....|...
gi 530361198  726 VPT-GAEASTESQ 737
Cdd:PRK07003  596 VPTpRARAATGDA 608
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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