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Conserved domains on  [gi|529015990|ref|XP_005228489|]
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ankyrin repeat and SOCS box protein 11 isoform X2 [Bos taurus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
43-261 3.96e-35

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 128.53  E-value: 3.96e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529015990  43 ADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGS 122
Cdd:COG0666   53 LGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGN 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529015990 123 AACVNVLLEFGAKA-QLEVHLASPIHEAVKRGNRECMEILLANNVNIDQEVPHLGTPLYAACTYQRLDCVKKLLELGANV 201
Cdd:COG0666  133 LEIVKLLLEAGADVnAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADV 212

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 529015990 202 NH-GQWLDTPLHAAAKQNSVEIIHLLIDYGANLKCKNAQGQSALDLAAPKSSVEQALLLRE 261
Cdd:COG0666  213 NAkDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLL 273
SOCS super family cl02533
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 261-302 4.73e-18

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


The actual alignment was detected with superfamily member cd03728:

Pssm-ID: 470605  Cd Length: 42  Bit Score: 75.98  E-value: 4.73e-18
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 529015990 261 EGPPALSQLCRLCVRKCLGRNCHKTIHKLYLPDPLEKFLLYQ 302
Cdd:cd03728    1 EGPPSLMQLCRLCIRKCFGRKQHHKIHKLHLPEPLKHFLLYR 42
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
43-261 3.96e-35

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 128.53  E-value: 3.96e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529015990  43 ADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGS 122
Cdd:COG0666   53 LGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGN 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529015990 123 AACVNVLLEFGAKA-QLEVHLASPIHEAVKRGNRECMEILLANNVNIDQEVPHLGTPLYAACTYQRLDCVKKLLELGANV 201
Cdd:COG0666  133 LEIVKLLLEAGADVnAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADV 212

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 529015990 202 NH-GQWLDTPLHAAAKQNSVEIIHLLIDYGANLKCKNAQGQSALDLAAPKSSVEQALLLRE 261
Cdd:COG0666  213 NAkDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLL 273
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 45-247 1.39e-18

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 85.89  E-value: 1.39e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529015990  45 RSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLEN------------------------- 99
Cdd:PHA02876 179 ITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNrsninkndlsllkairnedletsll 258

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529015990 100 ----GAHVNGVTVHGATPLFNACCSGS-AACVNVLLEFGAKAQLE-VHLASPIHEAVKRG-NRECMEILLANNVNIDQEV 172
Cdd:PHA02876 259 lydaGFSVNSIDDCKNTPLHHASQAPSlSRLVPKLLERGADVNAKnIKGETPLYLMAKNGyDTENIRTLIMLGADVNAAD 338

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 529015990 173 PHLGTPLYAACTYQRL-DCVKKLLELGANVNHGQWLD-TPLHAAAKQNSVEIIHLLIDYGANLKCKNAQGQSALDLA 247
Cdd:PHA02876 339 RLYITPLHQASTLDRNkDIVITLLELGANVNARDYCDkTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFA 415
SOCS_ASB_9_11 cd03728
SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have ...
 261-302 4.73e-18

SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239698  Cd Length: 42  Bit Score: 75.98  E-value: 4.73e-18
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 529015990 261 EGPPALSQLCRLCVRKCLGRNCHKTIHKLYLPDPLEKFLLYQ 302
Cdd:cd03728    1 EGPPSLMQLCRLCIRKCFGRKQHHKIHKLHLPEPLKHFLLYR 42
Ank_2 pfam12796
Ankyrin repeats (3 copies);
146-237 7.61e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 71.30  E-value: 7.61e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529015990  146 IHEAVKRGNRECMEILLANNVNIDQEVPHLGTPLYAACTYQRLDCVKKLLElGANVNHGQWLDTPLHAAAKQNSVEIIHL 225
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDNGRTALHYAARSGHLEIVKL 79

                          90
                  ....*....|..
gi 529015990  226 LIDYGANLKCKN 237
Cdd:pfam12796  80 LLEKGADINVKD 91
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 262-300 2.51e-10

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 54.86  E-value: 2.51e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 529015990  262 GPPALSQLCRLCVRKCLGRNCHKTIHKLYLPDPLEKFLL 300
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRRLGAIDKLPLPPLLKDYLL 39
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 264-302 2.36e-05

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 40.47  E-value: 2.36e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 529015990   264 PALSQLCRLCVRKCLGRnchktIHKLYLPDPLEKFLLYQ 302
Cdd:smart00969   1 RSLQHLCRLAIRRSLGG-----IDKLPLPPRLKDYLLYY 34
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 112-244 1.49e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 43.08  E-value: 1.49e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529015990 112 TPLFNACCSGSAACVNVLLEFGAKAQLE--VHLASPIHEAVKRGNRECMEILLAN-----NVNIDQEvPHLG-TPLYAAC 183
Cdd:cd22192   19 SPLLLAAKENDVQAIKKLLKCPSCDLFQrgALGETALHVAALYDNLEAAVVLMEAapelvNEPMTSD-LYQGeTALHIAV 97

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 529015990 184 TYQRLDCVKKLLELGANVNHGQWLDT---------------PLHAAAKQNSVEIIHLLIDYGANLKCKNAQGQSAL 244
Cdd:cd22192   98 VNQNLNLVRELIARGADVVSPRATGTffrpgpknliyygehPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVL 173
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 208-233 4.31e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.80  E-value: 4.31e-04
                           10        20
                   ....*....|....*....|....*.
gi 529015990   208 DTPLHAAAKQNSVEIIHLLIDYGANL 233
Cdd:smart00248   3 RTPLHLAAENGNLEVVKLLLDKGADI 28
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
43-261 3.96e-35

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 128.53  E-value: 3.96e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529015990  43 ADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGS 122
Cdd:COG0666   53 LGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGN 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529015990 123 AACVNVLLEFGAKA-QLEVHLASPIHEAVKRGNRECMEILLANNVNIDQEVPHLGTPLYAACTYQRLDCVKKLLELGANV 201
Cdd:COG0666  133 LEIVKLLLEAGADVnAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADV 212

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 529015990 202 NH-GQWLDTPLHAAAKQNSVEIIHLLIDYGANLKCKNAQGQSALDLAAPKSSVEQALLLRE 261
Cdd:COG0666  213 NAkDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLL 273
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
43-261 4.22e-33

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 123.14  E-value: 4.22e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529015990  43 ADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGS 122
Cdd:COG0666   20 LLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGD 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529015990 123 AACVNVLLEFGAK-AQLEVHLASPIHEAVKRGNRECMEILLANNVNIDQEVPHLGTPLYAACTYQRLDCVKKLLELGANV 201
Cdd:COG0666  100 LEIVKLLLEAGADvNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADV 179

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 529015990 202 NH-GQWLDTPLHAAAKQNSVEIIHLLIDYGANLKCKNAQGQSALDLAAPKSSVEQALLLRE 261
Cdd:COG0666  180 NArDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLE 240
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
44-202 2.20e-25

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 102.72  E-value: 2.20e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529015990  44 DRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSA 123
Cdd:COG0666  120 GETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHL 199

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529015990 124 ACVNVLLEFGAKAQLEVHL-ASPIHEAVKRGNRECMEILLANNVNIDQEVPHLGTPLYAACTYQRLDCVKKLLELGANVN 202
Cdd:COG0666  200 EIVKLLLEAGADVNAKDNDgKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLA 279
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 45-247 1.39e-18

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 85.89  E-value: 1.39e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529015990  45 RSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLEN------------------------- 99
Cdd:PHA02876 179 ITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNrsninkndlsllkairnedletsll 258

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529015990 100 ----GAHVNGVTVHGATPLFNACCSGS-AACVNVLLEFGAKAQLE-VHLASPIHEAVKRG-NRECMEILLANNVNIDQEV 172
Cdd:PHA02876 259 lydaGFSVNSIDDCKNTPLHHASQAPSlSRLVPKLLERGADVNAKnIKGETPLYLMAKNGyDTENIRTLIMLGADVNAAD 338

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 529015990 173 PHLGTPLYAACTYQRL-DCVKKLLELGANVNHGQWLD-TPLHAAAKQNSVEIIHLLIDYGANLKCKNAQGQSALDLA 247
Cdd:PHA02876 339 RLYITPLHQASTLDRNkDIVITLLELGANVNARDYCDkTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFA 415
SOCS_ASB_9_11 cd03728
SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have ...
 261-302 4.73e-18

SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239698  Cd Length: 42  Bit Score: 75.98  E-value: 4.73e-18
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 529015990 261 EGPPALSQLCRLCVRKCLGRNCHKTIHKLYLPDPLEKFLLYQ 302
Cdd:cd03728    1 EGPPSLMQLCRLCIRKCFGRKQHHKIHKLHLPEPLKHFLLYR 42
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 41-263 1.75e-17

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 82.02  E-value: 1.75e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529015990  41 CWADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVA-----CAKALLENGAHVNGVTVHGATPLF 115
Cdd:PHA03100  32 YKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNLtdvkeIVKLLLEYGANVNAPDNNGITPLL 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529015990 116 NA--CCSGSAACVNVLLEFGAKAQL-EVHLASPIHEAVKRGNR--ECMEILLANNVNIDQEvphlgtplyaactyqrlDC 190
Cdd:PHA03100 112 YAisKKSNSYSIVEYLLDNGANVNIkNSDGENLLHLYLESNKIdlKILKLLIDKGVDINAK-----------------NR 174

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 529015990 191 VKKLLELGANVN----HGqwlDTPLHAAAKQNSVEIIHLLIDYGANLKCKNAQGQSALDLAAPKSSVE-QALLLREGP 263
Cdd:PHA03100 175 VNYLLSYGVPINikdvYG---FTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEiFKLLLNNGP 249
Ank_2 pfam12796
Ankyrin repeats (3 copies);
146-237 7.61e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 71.30  E-value: 7.61e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529015990  146 IHEAVKRGNRECMEILLANNVNIDQEVPHLGTPLYAACTYQRLDCVKKLLElGANVNHGQWLDTPLHAAAKQNSVEIIHL 225
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDNGRTALHYAARSGHLEIVKL 79

                          90
                  ....*....|..
gi 529015990  226 LIDYGANLKCKN 237
Cdd:pfam12796  80 LLEKGADINVKD 91
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
42-179 1.18e-15

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 75.76  E-value: 1.18e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529015990  42 WADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSG 121
Cdd:COG0666  151 NDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENG 230

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 529015990 122 SAACVNVLLEFGAKAQLEV-HLASPIHEAVKRGNRECMEILLANNVNIDQEVPHLGTPL 179
Cdd:COG0666  231 NLEIVKLLLEAGADLNAKDkDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 46-258 1.20e-15

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 77.03  E-value: 1.20e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529015990  46 SPLHEAAAQGRLLAL-KTLIAQGVNVNLVTINRVSSLHEACLGGH-VACAKALLENGAHVNGVTVHGATPLFNACC-SGS 122
Cdd:PHA02876 275 TPLHHASQAPSLSRLvPKLLERGADVNAKNIKGETPLYLMAKNGYdTENIRTLIMLGADVNAADRLYITPLHQASTlDRN 354

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529015990 123 AACVNVLLEFGAKAQL-EVHLASPIHEAVKRGNRECMEILLANNVNIDQEVPHLGTPL-YAACTYQRLDCVKKLLELGAN 200
Cdd:PHA02876 355 KDIVITLLELGANVNArDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALhFALCGTNPYMSVKTLIDRGAN 434

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 529015990 201 VN-HGQWLDTPLHAAAKQN-SVEIIHLLIDYGANLKCKNAQGQSALDLAAPKSSVEQALL 258
Cdd:PHA02876 435 VNsKNKDLSTPLHYACKKNcKLDVIEMLLDNGADVNAINIQNQYPLLIALEYHGIVNILL 494
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 60-247 1.59e-15

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 76.54  E-value: 1.59e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529015990  60 LKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQL- 138
Cdd:PHA02874 107 IKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVk 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529015990 139 EVHLASPIHEAVKRGNRECMEILLANNVNIDQEVPHLGTPLYAACTYQRldCVKKLLELGANVNHgQWLD--TPLHAAAK 216
Cdd:PHA02874 187 DNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNR--SAIELLINNASIND-QDIDgsTPLHHAIN 263

                        170       180       190
                 ....*....|....*....|....*....|..
gi 529015990 217 QN-SVEIIHLLIDYGANLKCKNAQGQSALDLA 247
Cdd:PHA02874 264 PPcDIDIIDILLYHKADISIKDNKGENPIDTA 295
SOCS_ASB_like cd03716
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB ...
 261-302 2.43e-14

SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable number of repeats. SSB proteins contain a central SPRY domain and a C-terminal SOCS. Recently, it has been shown that all four SSB proteins interact with the MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), and that SSB-1, SSB-2, and SSB-4 interact with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain.


Pssm-ID: 239686  Cd Length: 42  Bit Score: 65.98  E-value: 2.43e-14
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 529015990 261 EGPPALSQLCRLCVRKCLGRNCHKTIHKLYLPDPLEKFLLYQ 302
Cdd:cd03716    1 STPRSLQHLCRLAIRRCLGRRRLELIKKLPLPPRLKDYLLYE 42
Ank_2 pfam12796
Ankyrin repeats (3 copies);
81-170 2.81e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 67.06  E-value: 2.81e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529015990   81 LHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFgAKAQLEVHLASPIHEAVKRGNRECMEI 160
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGRTALHYAARSGHLEIVKL 79

                          90
                  ....*....|
gi 529015990  161 LLANNVNIDQ 170
Cdd:pfam12796  80 LLEKGADINV 89
Ank_2 pfam12796
Ankyrin repeats (3 copies);
48-135 5.01e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 66.29  E-value: 5.01e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529015990   48 LHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENgAHVNgVTVHGATPLFNACCSGSAACVN 127
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVN-LKDNGRTALHYAARSGHLEIVK 78


                  ....*...
gi 529015990  128 VLLEFGAK 135
Cdd:pfam12796  79 LLLEKGAD 86
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 94-252 3.72e-13

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 69.52  E-value: 3.72e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529015990  94 KALLENGAHVNGVTVH-GATPLFNACCSGSAACVNVLLEFGAKAQ-LEVHLASPIHEAVKRGNRECMEILLANNVNIDQE 171
Cdd:PHA02878 151 KLLLSYGADINMKDRHkGNTALHYATENKDQRLTELLLSYGANVNiPDKTNNSPLHHAVKHYNKPIVHILLENGASTDAR 230

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529015990 172 VPHLGTPLYAACTY-QRLDCVKKLLELGANVNHGQWLD--TPLHAAAKqnSVEIIHLLIDYGANLKCKNAQGQSALDLAA 248
Cdd:PHA02878 231 DKCGNTPLHISVGYcKDYDILKLLLEHGVDVNAKSYILglTALHSSIK--SERKLKLLLEYGADINSLNSYKLTPLSSAV 308


                 ....
gi 529015990 249 PKSS 252
Cdd:PHA02878 309 KQYL 312
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 55-248 1.07e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 68.07  E-value: 1.07e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529015990  55 GRLLALKTLIAQGVN-VNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFG 133
Cdd:PHA02874  12 GDIEAIEKIIKNKGNcINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNG 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529015990 134 AKAQLevhlaSPIHEAvkrgNRECMEILLANNVNIDQEVPHLGTPLYAACTYQRLDCVKKLLELGANVN----HGQWldt 209
Cdd:PHA02874  92 VDTSI-----LPIPCI----EKDMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNieddNGCY--- 159

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 529015990 210 PLHAAAKQNSVEIIHLLIDYGANLKCKNAQGQSALDLAA 248
Cdd:PHA02874 160 PIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAA 198
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 46-232 3.56e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 66.17  E-value: 3.56e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529015990  46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVH-GATPLFNACCSGSAA 124
Cdd:PHA02875  37 SPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKFADDVFYKdGMTPLHLATILKKLD 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529015990 125 CVNVLLEFGAKAQL-EVHLASPIHEAVKRGNRECMEILLANNVNIDQEVPHLGTPLYAACTYQRLDCVKKLLELGANVNH 203
Cdd:PHA02875 117 IMKLLIARGADPDIpNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDY 196

                        170       180       190
                 ....*....|....*....|....*....|.
gi 529015990 204 -GQWLD-TPLHAAAKQNSVEIIHLLIDYGAN 232
Cdd:PHA02875 197 fGKNGCvAALCYAIENNKIDIVRLFIKRGAD 227
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 80-254 1.30e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 64.63  E-value: 1.30e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529015990  80 SLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEV-HLASPIHEAVKRGNRECM 158
Cdd:PHA02875   5 ALCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYpDIESELHDAVEEGDVKAV 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529015990 159 EILLANNVNIDQEVPHLG-TPLYAACTYQRLDCVKKLLELGANVNHGQwLD--TPLHAAAKQNSVEIIHLLIDYGANLKC 235
Cdd:PHA02875  85 EELLDLGKFADDVFYKDGmTPLHLATILKKLDIMKLLIARGADPDIPN-TDkfSPLHLAVMMGDIKGIELLIDHKACLDI 163

                        170
                 ....*....|....*....
gi 529015990 236 KNAQGQSALDLAAPKSSVE 254
Cdd:PHA02875 164 EDCCGCTPLIIAMAKGDIA 182
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 48-241 1.34e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 64.60  E-value: 1.34e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529015990  48 LHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVN 127
Cdd:PHA02874 128 LHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIK 207

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529015990 128 VLLEFGAKAQLEVHLA-SPIHEAVKRgNRECMEiLLANNVNIDQEVPHLGTPLYAACTYQ-RLDCVKKLLELGANV---- 201
Cdd:PHA02874 208 LLIDHGNHIMNKCKNGfTPLHNAIIH-NRSAIE-LLINNASINDQDIDGSTPLHHAINPPcDIDIIDILLYHKADIsikd 285

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 529015990 202 NHGQwldTPLHAAAKQ-NSVEIIHLLIdygANLKCKNAQGQ 241
Cdd:PHA02874 286 NKGE---NPIDTAFKYiNKDPVIKDII---ANAVLIKEADK 320
SOCS cd03587
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 263-302 1.64e-11

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239641  Cd Length: 41  Bit Score: 57.87  E-value: 1.64e-11
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 529015990 263 PPALSQLCRLCVRKCLGRNCHKTIHKLYLPDPLEKFLLYQ 302
Cdd:cd03587    2 PRSLQHLCRLAIRRCLGKRRLDLIDKLPLPPRLKDYLLYK 41
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 46-237 6.17e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 62.67  E-value: 6.17e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529015990  46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVhgatPLFNAccsgsaAC 125
Cdd:PHA02874  37 TPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVDTSILPI----PCIEK------DM 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529015990 126 VNVLLEFGAKAQL-EVHLASPIHEAVKRGNRECMEILLANNVNIDQEVPHLGTPLYAACTYQRLDCVKKLLELGA--NVN 202
Cdd:PHA02874 107 IKTILDCGIDVNIkDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAyaNVK 186

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 529015990 203 HgQWLDTPLHAAAKQNSVEIIHLLIDYGANL--KCKN 237
Cdd:PHA02874 187 D-NNGESPLHNAAEYGDYACIKLLIDHGNHImnKCKN 222
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 262-300 2.51e-10

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 54.86  E-value: 2.51e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 529015990  262 GPPALSQLCRLCVRKCLGRNCHKTIHKLYLPDPLEKFLL 300
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRRLGAIDKLPLPPLLKDYLL 39
PHA03095 PHA03095
ankyrin-like protein; Provisional
 50-245 1.83e-09

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 58.11  E-value: 1.83e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529015990  50 EAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAK---ALLENGAHVNGVTVHGATPLFnaCCSGSAACV 126
Cdd:PHA03095  20 LNASNVTVEEVRRLLAAGADVNFRGEYGKTPLHLYLHYSSEKVKDivrLLLEAGADVNAPERCGFTPLH--LYLYNATTL 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529015990 127 NVllefgakaqlevhlaspiheavkrgnrecMEILLANNVNIDQEVPHLGTPLYAACTYQRLD--CVKKLLELGANVN-- 202
Cdd:PHA03095  98 DV-----------------------------IKLLIKAGADVNAKDKVGRTPLHVYLSGFNINpkVIRLLLRKGADVNal 148

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 529015990 203 --HGQwldTPLHAAAKQN--SVEIIHLLIDYGANLKCKNAQGQSALD 245
Cdd:PHA03095 149 dlYGM---TPLAVLLKSRnaNVELLRLLIDAGADVYAVDDRFRSLLH 192
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 112-261 3.00e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 57.67  E-value: 3.00e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529015990 112 TPLFNACCSGSAACVNVLLEFGAKA-QLEVHLASPIHEAVKRGNRECMEILLANNVNID-QEVPHLGTplyaactyqrlD 189
Cdd:PHA02874  37 TPLIDAIRSGDAKIVELFIKHGADInHINTKIPHPLLTAIKIGAHDIIKLLIDNGVDTSiLPIPCIEK-----------D 105

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 529015990 190 CVKKLLELGANVN-HGQWLDTPLHAAAKQNSVEIIHLLIDYGANLKCKNAQGQSALDLAAPKSSVEQALLLRE 261
Cdd:PHA02874 106 MIKTILDCGIDVNiKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLE 178
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 74-248 3.81e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 57.38  E-value: 3.81e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529015990  74 TINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQ-LEVHLASPIHEAVKR 152
Cdd:PHA02876 142 SIEYMKLIKERIQQDELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNiIALDDLSVLECAVDS 221

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529015990 153 GNRECMEILLANNVNIDQEvphlGTPLYAACTYQRLDCVKKLLELGANVNH-GQWLDTPLHAAAKQNSV-EIIHLLIDYG 230
Cdd:PHA02876 222 KNIDTIKAIIDNRSNINKN----DLSLLKAIRNEDLETSLLLYDAGFSVNSiDDCKNTPLHHASQAPSLsRLVPKLLERG 297

                        170
                 ....*....|....*...
gi 529015990 231 ANLKCKNAQGQSALDLAA 248
Cdd:PHA02876 298 ADVNAKNIKGETPLYLMA 315
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
127-259 5.36e-09

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 56.12  E-value: 5.36e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529015990 127 NVLLEFGAKAQLEVHLASPIHEAVKRGNRECMEILLANNVNIDQEVPHLGTPLYAACTYQRLDCVKKLLELGANVNH-GQ 205
Cdd:COG0666    6 LLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAkDD 85

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 529015990 206 WLDTPLHAAAKQNSVEIIHLLIDYGANLKCKNAQGQSALDLAAPKSSVEQALLL 259
Cdd:COG0666   86 GGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLL 139
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 114-259 7.23e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 56.15  E-value: 7.23e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529015990 114 LFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKRGNRECMEILLANNVNIDQEVPHLGTPLYAACTYQRLDCVK 192
Cdd:PHA02875   6 LCDAILFGELDIARRLLDIGINPNFEIYDGiSPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVE 85

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 529015990 193 KLLELGANVNHGQWLD--TPLHAAAKQNSVEIIHLLIDYGANLKCKNAQGQSALDLAAPKSSVEQALLL 259
Cdd:PHA02875  86 ELLDLGKFADDVFYKDgmTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELL 154
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 51-203 4.80e-08

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 54.10  E-value: 4.80e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529015990  51 AAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLL 130
Cdd:PLN03192 532 VASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILY 611

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 529015990 131 EFGAKAqlEVHLASPIH-EAVKRGNRECMEILLANNVNIDQEVPHLGTPLYAACTYQRLDCVKKLLELGANVNH 203
Cdd:PLN03192 612 HFASIS--DPHAAGDLLcTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDK 683
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 46-175 7.26e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 53.13  E-value: 7.26e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529015990  46 SPLHEAAAQGR--LLALKTLIAQGVNVNLvtINRVsslheaclgghvacaKALLENGAHVNGVTVHGATPLFNACCSGSA 123
Cdd:PHA03100 143 NLLHLYLESNKidLKILKLLIDKGVDINA--KNRV---------------NYLLSYGVPINIKDVYGFTPLHYAVYNNNP 205

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 529015990 124 ACVNVLLEFGA----KAQLEVhlaSPIHEAVKRGNRECMEILLANNVNIDQEVPHL 175
Cdd:PHA03100 206 EFVKYLLDLGAnpnlVNKYGD---TPLHIAILNNNKEIFKLLLNNGPSIKTIIETL 258
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 44-227 9.15e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 52.96  E-value: 9.15e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529015990  44 DRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLfnaccsgsa 123
Cdd:PHA02878 168 GNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPL--------- 238

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529015990 124 acvnvllefgakaqlevhlaspiHEAVKR-GNRECMEILLANNVNIDQEVPHLG-TPLYAACTYQRLdcVKKLLELGANV 201
Cdd:PHA02878 239 -----------------------HISVGYcKDYDILKLLLEHGVDVNAKSYILGlTALHSSIKSERK--LKLLLEYGADI 293

                        170       180
                 ....*....|....*....|....*...
gi 529015990 202 NHGQWL-DTPLHAAAKQNS-VEIIHLLI 227
Cdd:PHA02878 294 NSLNSYkLTPLSSAVKQYLcINIGRILI 321
SOCS_ASB2 cd03721
SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a ...
 261-302 2.36e-07

SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB2 targets specific proteins to destruction by the proteasome in leukemia cells that have been induced to differentiate. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239691  Cd Length: 45  Bit Score: 46.40  E-value: 2.36e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 529015990 261 EGPPALSQLCRLCVRKCLGRNCHKTIHKLYLPDPLEKFLLYQ 302
Cdd:cd03721    1 EPPRPLAHLCRLKVRTLIGINRIKLIDTLPLPPRLIRYLNHQ 42
Ank_4 pfam13637
Ankyrin repeats (many copies);
45-97 3.32e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 46.50  E-value: 3.32e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 529015990   45 RSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALL 97
Cdd:pfam13637   2 LTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 93-162 3.35e-07

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 51.44  E-value: 3.35e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 529015990  93 AKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQ-LEVHLASPIHEAVKRGNRECMEILL 162
Cdd:PTZ00322  98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTlLDKDGKTPLELAEENGFREVVQLLS 168
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 13-134 4.71e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 50.76  E-value: 4.71e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529015990  13 EVSESGRSLGVWKEISFGDYICHTFQGDcwaDRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVAC 92
Cdd:PHA02875  74 DAVEEGDVKAVEELLDLGKFADDVFYKD---GMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKG 150

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 529015990  93 AKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGA 134
Cdd:PHA02875 151 IELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGA 192
SOCS_SSB1_4 cd03718
SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box ...
 263-302 5.81e-07

SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF) and also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239688  Cd Length: 42  Bit Score: 45.37  E-value: 5.81e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 529015990 263 PPALSQLCRLCVRKCLGRNCHKTIHKLYLPDPLEKFLLYQ 302
Cdd:cd03718    3 PLPLMDLCRRRVRVALGRDRLEEIEQLPLPPSLKNYLLYQ 42
PHA03095 PHA03095
ankyrin-like protein; Provisional
 60-203 6.10e-07

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 50.41  E-value: 6.10e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529015990  60 LKTLIAQGVNVNLVTINRVSSLHeACLGG---HVACAKALLENGAHVNGVTVHGATPLfnACCSGSAAC----VNVLLEF 132
Cdd:PHA03095 100 IKLLIKAGADVNAKDKVGRTPLH-VYLSGfniNPKVIRLLLRKGADVNALDLYGMTPL--AVLLKSRNAnvelLRLLIDA 176

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529015990 133 GAKAQ---------LEVHLASP------IHEAVKRG-----------------------NRECMEILLANNVNIDQEVPH 174
Cdd:PHA03095 177 GADVYavddrfrslLHHHLQSFkprariVRELIRAGcdpaatdmlgntplhsmatgsscKRSLVLPLLIAGISINARNRY 256

                        170       180       190
                 ....*....|....*....|....*....|
gi 529015990 175 LGTPL-YAACTYQRLDCVKkLLELGANVNH 203
Cdd:PHA03095 257 GQTPLhYAAVFNNPRACRR-LIALGADINA 285
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 47-200 8.97e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 49.96  E-value: 8.97e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529015990  47 PLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAAcV 126
Cdd:PHA02874 160 PIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNRSA-I 238

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 529015990 127 NVLLEFGAKAQLEVHLASPIHEAVKRG-NRECMEILLANNVNIDQEVPHLGTPLYAACTYQRLDCVKKllELGAN 200
Cdd:PHA02874 239 ELLINNASINDQDIDGSTPLHHAINPPcDIDIIDILLYHKADISIKDNKGENPIDTAFKYINKDPVIK--DIIAN 311
SOCS_ASB5 cd03724
SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a ...
 263-302 3.10e-06

SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB5 has been implicated in the initiation of arteriogenesis. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239694  Cd Length: 42  Bit Score: 43.33  E-value: 3.10e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 529015990 263 PPALSQLCRLCVRKCLGRNCHKTIHKLYLPDPLEKFLLYQ 302
Cdd:cd03724    3 PSSLCQLCRLCIRNYIGRSRLHLIPQLQLPTLLKNFLQYR 42
Ank_4 pfam13637
Ankyrin repeats (many copies);
177-227 3.32e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 43.42  E-value: 3.32e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 529015990  177 TPLYAACTYQRLDCVKKLLELGANVNH--GQWlDTPLHAAAKQNSVEIIHLLI 227
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAvdGNG-ETALHFAASNGNVEVLKLLL 54
Ank_2 pfam12796
Ankyrin repeats (3 copies);
45-104 3.36e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 44.72  E-value: 3.36e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 529015990   45 RSPLHEAAAQGRLLALKTLIAQgVNVNLVTINRvSSLHEACLGGHVACAKALLENGAHVN 104
Cdd:pfam12796  31 RTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGR-TALHYAARSGHLEIVKLLLEKGADIN 88
SOCS_ASB1 cd03720
SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a ...
 263-302 5.14e-06

SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239690  Cd Length: 42  Bit Score: 42.79  E-value: 5.14e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 529015990 263 PPALSQLCRLCVRKCLGRNCHKTIHKLYLPDPLEKFLLYQ 302
Cdd:cd03720    3 PRSLLSLCRIAVRRALGKQRLSLICSLPLPDPIKKFLLHE 42
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 81-262 6.68e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 47.18  E-value: 6.68e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529015990  81 LHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNAC-----------------CSGS--------------------- 122
Cdd:PHA02878  41 LHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICkepnklgmkemirsinkCSVFytlvaikdafnnrnveifkii 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529015990 123 --------------------------AACVNVLLEFGAKAQL--EVHLASPIHEAVKRGNRECMEILLANNVNIDqeVPH 174
Cdd:PHA02878 121 ltnrykniqtidlvyidkkskddiieAEITKLLLSYGADINMkdRHKGNTALHYATENKDQRLTELLLSYGANVN--IPD 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529015990 175 LG--TPLYAACTYQRLDCVKKLLELGANVNH-GQWLDTPLH-AAAKQNSVEIIHLLIDYGAnlkCKNAQ----GQSALDL 246
Cdd:PHA02878 199 KTnnSPLHHAVKHYNKPIVHILLENGASTDArDKCGNTPLHiSVGYCKDYDILKLLLEHGV---DVNAKsyilGLTALHS 275

                        250
                 ....*....|....*.
gi 529015990 247 AApKSSVEQALLLREG 262
Cdd:PHA02878 276 SI-KSERKLKLLLEYG 290
Ank_5 pfam13857
Ankyrin repeats (many copies);
194-247 7.49e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 42.72  E-value: 7.49e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 529015990  194 LLELG-ANVNH-GQWLDTPLHAAAKQNSVEIIHLLIDYGANLKCKNAQGQSALDLA 247
Cdd:pfam13857   1 LLEHGpIDLNRlDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
Ank_4 pfam13637
Ankyrin repeats (many copies);
209-259 1.68e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 41.49  E-value: 1.68e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 529015990  209 TPLHAAAKQNSVEIIHLLIDYGANLKCKNAQGQSALDLAAPKSSVEQALLL 259
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
SOCS_ASB4_ASB18 cd03723
SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members ...
 263-300 2.14e-05

SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239693  Cd Length: 48  Bit Score: 41.27  E-value: 2.14e-05
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 529015990 263 PPALSQLCRLCVRKCLGRNCHKTIHKLYLPDPLEKFLL 300
Cdd:cd03723    3 PRSLQHLCRCAIRKLLGSRCHKLVPQLSLPTSLKNYLL 40
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 264-302 2.36e-05

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 40.47  E-value: 2.36e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 529015990   264 PALSQLCRLCVRKCLGRnchktIHKLYLPDPLEKFLLYQ 302
Cdd:smart00969   1 RSLQHLCRLAIRRSLGG-----IDKLPLPPRLKDYLLYY 34
SOCS_SSB1 cd03744
SOCS (suppressors of cytokine signaling) box of SSB1 (SPRY domain-containing SOCS box proteins) ...
 263-302 4.06e-05

SOCS (suppressors of cytokine signaling) box of SSB1 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), both the absence and the presence of HGF and enhances the HGF-MET-induced mitogen-activated protein kinases Erk-transcription factor Elk-1-serum response elements (SRE) pathway. SSB1, like SSB2 and SSB4, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239713  Cd Length: 42  Bit Score: 40.35  E-value: 4.06e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 529015990 263 PPALSQLCRLCVRKCLGRNCHKTIHKLYLPDPLEKFLLYQ 302
Cdd:cd03744    3 PLPLMDLCRRSVRLALGRERLSEIHTLPLPASLKNYLLYQ 42
SOCS_ASB13 cd03729
SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a ...
 263-301 4.94e-05

SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239699  Cd Length: 42  Bit Score: 39.77  E-value: 4.94e-05
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 529015990 263 PPALSQLCRLCVRKCLGRNCHKTIHKLYLPDPLEKFLLY 301
Cdd:cd03729    3 PLSLQQLCRINLRKALGTRALEKIAKLNIPNRIIDYLSY 41
Ank_4 pfam13637
Ankyrin repeats (many copies);
77-130 5.17e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 40.34  E-value: 5.17e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 529015990   77 RVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLL 130
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 48-136 7.33e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 44.12  E-value: 7.33e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529015990  48 LHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVN 127
Cdd:PTZ00322  86 LCQLAASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQ 165

                         90
                 ....*....|....*.
gi 529015990 128 VLL-------EFGAKA 136
Cdd:PTZ00322 166 LLSrhsqchfELGANA 181
PHA03095 PHA03095
ankyrin-like protein; Provisional
 180-262 8.50e-05

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 43.86  E-value: 8.50e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529015990 180 YAACTYQRLDCVKKLLELGANVNH-GQWLDTPLHA---AAKQNSVEIIHLLIDYGANLKCKNAQGQSALDLAAPKSSVEQ 255
Cdd:PHA03095  19 LLNASNVTVEEVRRLLAAGADVNFrGEYGKTPLHLylhYSSEKVKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATTLD 98


                 ....*....
gi 529015990 256 --ALLLREG 262
Cdd:PHA03095  99 viKLLIKAG 107
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 42-135 1.12e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 43.51  E-value: 1.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529015990  42 WADRSPLHEAAAQGRL----------------------------------LALKTLIAQGVNVNLVTINRVSSLHEACLG 87
Cdd:PHA02876 373 YCDKTPIHYAAVRNNVviintlldygadiealsqkigtalhfalcgtnpyMSVKTLIDRGANVNSKNKDLSTPLHYACKK 452

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 529015990  88 G-HVACAKALLENGAHVNGVTVHGATPLFNACcsGSAACVNVLLEFGAK 135
Cdd:PHA02876 453 NcKLDVIEMLLDNGADVNAINIQNQYPLLIAL--EYHGIVNILLHYGAE 499
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 112-244 1.49e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 43.08  E-value: 1.49e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529015990 112 TPLFNACCSGSAACVNVLLEFGAKAQLE--VHLASPIHEAVKRGNRECMEILLAN-----NVNIDQEvPHLG-TPLYAAC 183
Cdd:cd22192   19 SPLLLAAKENDVQAIKKLLKCPSCDLFQrgALGETALHVAALYDNLEAAVVLMEAapelvNEPMTSD-LYQGeTALHIAV 97

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 529015990 184 TYQRLDCVKKLLELGANVNHGQWLDT---------------PLHAAAKQNSVEIIHLLIDYGANLKCKNAQGQSAL 244
Cdd:cd22192   98 VNQNLNLVRELIARGADVVSPRATGTffrpgpknliyygehPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVL 173
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 46-170 2.38e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 42.26  E-value: 2.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529015990  46 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLggHVACAKALLENGAHVNGVTVHGATPLFNAC---CSGS 122
Cdd:PHA02874 192 SPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAII--HNRSAIELLINNASINDQDIDGSTPLHHAInppCDID 269

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 529015990 123 AacVNVLLEFGAKAQLEVHLA-SPIHEAVKRGNRE-CMEILLANNVNIDQ 170
Cdd:PHA02874 270 I--IDILLYHKADISIKDNKGeNPIDTAFKYINKDpVIKDIIANAVLIKE 317
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 160-252 4.04e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 41.81  E-value: 4.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529015990 160 ILLANNVNIDQEVPHLGTPLYAACTYQRLDCVKKLLELGANVNhgqWLD----TPLHAAAKQNSVEIIHLLI-------D 228
Cdd:PTZ00322 100 ILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPT---LLDkdgkTPLELAEENGFREVVQLLSrhsqchfE 176

                         90       100
                 ....*....|....*....|....
gi 529015990 229 YGANLKCKNAQGQSALDLAAPKSS 252
Cdd:PTZ00322 177 LGANAKPDSFTGKPPSLEDSPISS 200
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 208-233 4.31e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.80  E-value: 4.31e-04
                           10        20
                   ....*....|....*....|....*.
gi 529015990   208 DTPLHAAAKQNSVEIIHLLIDYGANL 233
Cdd:smart00248   3 RTPLHLAAENGNLEVVKLLLDKGADI 28
SOCS_SSB4 cd03743
SOCS (suppressors of cytokine signaling) box of SSB4 (SPRY domain-containing SOCS box ...
 263-302 8.48e-04

SOCS (suppressors of cytokine signaling) box of SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF). SSB4, like SSB2 and SSB1, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239712  Cd Length: 42  Bit Score: 36.47  E-value: 8.48e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 529015990 263 PPALSQLCRLCVRKCLGRNCHKTIHKLYLPDPLEKFLLYQ 302
Cdd:cd03743    3 PLPLMDLCRRSARQALGRHRLHHIQSLPLPQTLKNYLQYQ 42
SOCS_ASB14 cd03730
SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a ...
 261-302 1.30e-03

SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239700  Cd Length: 57  Bit Score: 36.36  E-value: 1.30e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 529015990 261 EGPPALSQLCRLCVRKCLGR---NCHKTIHKLYLPDPLEKFLLYQ 302
Cdd:cd03730    1 TNPRSLKHLCRLKIRACMGRlrlRCPVFMSFLPLPNRLKAYILYK 45
SOCS_SSB2 cd03719
SOCS (suppressors of cytokine signaling) box of SSB2 (SPRY domain-containing SOCS box proteins) ...
 261-302 1.34e-03

SOCS (suppressors of cytokine signaling) box of SSB2 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB2 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF). SSB2, like SSB4 and SSB1, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239689  Cd Length: 42  Bit Score: 35.77  E-value: 1.34e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 529015990 261 EGPPALSQLCRLCVRKCLGRNCHKTIHKLYLPDPLEKFLLYQ 302
Cdd:cd03719    1 AEPHSLLHLSRLCVRHALGDTRLGQVSALPLPPAMKRYLLYQ 42
Ank_2 pfam12796
Ankyrin repeats (3 copies);
211-248 1.42e-03

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 37.02  E-value: 1.42e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 529015990  211 LHAAAKQNSVEIIHLLIDYGANLKCKNAQGQSALDLAA 248
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAA 38
Ank_4 pfam13637
Ankyrin repeats (many copies);
144-195 1.82e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 35.71  E-value: 1.82e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 529015990  144 SPIHEAVKRGNRECMEILLANNVNIDqEVPHLG-TPLYAACTYQRLDCVKKLL 195
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADIN-AVDGNGeTALHFAASNGNVEVLKLLL 54
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 208-237 2.10e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 34.96  E-value: 2.10e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 529015990  208 DTPLHAAAKQ-NSVEIIHLLIDYGANLKCKN 237
Cdd:pfam00023   3 NTPLHLAAGRrGNLEIVKLLLSKGADVNARD 33
PHA02989 PHA02989
ankyrin repeat protein; Provisional
 189-242 2.29e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222954 [Multi-domain]  Cd Length: 494  Bit Score: 39.34  E-value: 2.29e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 529015990 189 DCVKKLLELGANVNHGQWLDTPLHAAAKQNSV------EIIHLLIDYGANLKCKNAQGQS 242
Cdd:PHA02989  51 KIVKLLIDNGADVNYKGYIETPLCAVLRNREItsnkikKIVKLLLKFGADINLKTFNGVS 110
PHA02798 PHA02798
ankyrin-like protein; Provisional
 94-244 2.60e-03

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 39.05  E-value: 2.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529015990  94 KALLENGAHVNGVTVHGATPLfnaCCSGSAACVNVL------LEFGAKAQLevhlaspiheaVKRGNRECMEILLANNVN 167
Cdd:PHA02798  93 KILIENGADINKKNSDGETPL---YCLLSNGYINNLeillfmIENGADTTL-----------LDKDGFTMLQVYLQSNHH 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529015990 168 IDqevphlgtplyaactyqrLDCVKKLLELGANVN-HGQWLD-TPLHAAAKQN----SVEIIHLLIDYGANLKCKNAQGQ 241
Cdd:PHA02798 159 ID------------------IEIIKLLLEKGVDINtHNNKEKyDTLHCYFKYNidriDADILKLFVDNGFIINKENKSHK 220


                 ...
gi 529015990 242 SAL 244
Cdd:PHA02798 221 KKF 223
Ank_5 pfam13857
Ankyrin repeats (many copies);
63-114 2.92e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 35.40  E-value: 2.92e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 529015990   63 LIAQG-VNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPL 114
Cdd:pfam13857   1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 11-109 4.46e-03

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 38.70  E-value: 4.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529015990  11 NLEVSESGRSLGVWKEISFGDY----ICHTFQ--GDCWADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEA 84
Cdd:PLN03192 583 NVHIRDANGNTALWNAISAKHHkifrILYHFAsiSDPHAAGDLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVA 662

                         90       100
                 ....*....|....*....|....*
gi 529015990  85 CLGGHVACAKALLENGAHVNGVTVH 109
Cdd:PLN03192 663 MAEDHVDMVRLLIMNGADVDKANTD 687
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 194-254 4.72e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 38.51  E-value: 4.72e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 529015990 194 LLELGANVNHGQ-WLDTPLHAAAKQNSVEIIHLLIDYGANLKCKNAQGQSALDLAAPKSSVE 254
Cdd:PHA02876 164 LLEGGADVNAKDiYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNID 225
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 177-202 5.03e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.10  E-value: 5.03e-03
                           10        20
                   ....*....|....*....|....*.
gi 529015990   177 TPLYAACTYQRLDCVKKLLELGANVN 202
Cdd:smart00248   4 TPLHLAAENGNLEVVKLLLDKGADIN 29
PHA02859 PHA02859
ankyrin repeat protein; Provisional
 144-244 5.43e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165195 [Multi-domain]  Cd Length: 209  Bit Score: 37.49  E-value: 5.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529015990 144 SPIHEAV--KRGNRECMEILLANNVNIDQEVPHLG-TPLYAACTYQR---LDCVKKLLELGANVNHgqwLD----TPLHA 213
Cdd:PHA02859  53 TPIFSCLekDKVNVEILKFLIENGADVNFKTRDNNlSALHHYLSFNKnvePEILKILIDSGSSITE---EDedgkNLLHM 129

                         90       100       110
                 ....*....|....*....|....*....|...
gi 529015990 214 AAKQNSV--EIIHLLIDYGANLKCKNAQGQSAL 244
Cdd:PHA02859 130 YMCNFNVriNVIKLLIDSGVSFLNKDFDNNNIL 162
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 209-233 7.54e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 33.38  E-value: 7.54e-03
                          10        20
                  ....*....|....*....|....*
gi 529015990  209 TPLHAAAKQNSVEIIHLLIDYGANL 233
Cdd:pfam13606   4 TPLHLAARNGRLEIVKLLLENGADI 28
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 208-266 8.30e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 37.68  E-value: 8.30e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 529015990 208 DTPLHAAAKQNSVE-IIHLLIDYGANLKCKNAQGQSALDLAAPKSSVEQALLLREGPPAL 266
Cdd:cd22192   18 ESPLLLAAKENDVQaIKKLLKCPSCDLFQRGALGETALHVAALYDNLEAAVVLMEAAPEL 77
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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