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Conserved domains on  [gi|528492384|ref|XP_005172698|]
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transducin beta-like protein 2 isoform X1 [Danio rerio]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
72-389 8.44e-47

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 166.24  E-value: 8.44e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528492384  72 THQLLASALKSHSGHVTCLDFSSNGKYLASCSDDRTIRIWSTkdfldRDHKCLRA-NIEFDHATLVRFSPDSRAFITWLA 150
Cdd:COG2319  108 ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL-----ATGKLLRTlTGHSGAVTSVAFSPDGKLLASGSD 182

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528492384 151 NGeTIRIYKmVKKDDGTFNFKAapgdfpqkHKGVIINIGIAETGKFIMSASVDTTIVIWDLK-GEVLATINTNQMTNSHA 229
Cdd:COG2319  183 DG-TVRLWD-LATGKLLRTLTG--------HTGAVRSVAFSPDGKLLASGSADGTVRLWDLAtGKLLRTLTGHSGSVRSV 252

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528492384 230 AVSPCGRFVASCGFTPDVKVWEVcfgKSGEFREVarafdLKGHSAGVYSFDFSNDSRRMVTVSKDGTWKLWDTDveykkk 309
Cdd:COG2319  253 AFSPDGRLLASGSADGTVRLWDL---ATGELLRT-----LTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA------ 318

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528492384 310 qDPYLLRTVPCKVSEGSRIALSPDGRVVAI-SNVCDIAMYNATTGELEEEFhSVHNGEITDLKFDINNRFLLSTG-DRVI 387
Cdd:COG2319  319 -TGKLLRTLTGHTGAVRSVAFSPDGKTLASgSDDGTVRLWDLATGELLRTL-TGHTGAVTSVAFSPDGRTLASGSaDGTV 396


                 ..
gi 528492384 388 RV 389
Cdd:COG2319  397 RL 398
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
72-389 8.44e-47

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 166.24  E-value: 8.44e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528492384  72 THQLLASALKSHSGHVTCLDFSSNGKYLASCSDDRTIRIWSTkdfldRDHKCLRA-NIEFDHATLVRFSPDSRAFITWLA 150
Cdd:COG2319  108 ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL-----ATGKLLRTlTGHSGAVTSVAFSPDGKLLASGSD 182

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528492384 151 NGeTIRIYKmVKKDDGTFNFKAapgdfpqkHKGVIINIGIAETGKFIMSASVDTTIVIWDLK-GEVLATINTNQMTNSHA 229
Cdd:COG2319  183 DG-TVRLWD-LATGKLLRTLTG--------HTGAVRSVAFSPDGKLLASGSADGTVRLWDLAtGKLLRTLTGHSGSVRSV 252

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528492384 230 AVSPCGRFVASCGFTPDVKVWEVcfgKSGEFREVarafdLKGHSAGVYSFDFSNDSRRMVTVSKDGTWKLWDTDveykkk 309
Cdd:COG2319  253 AFSPDGRLLASGSADGTVRLWDL---ATGELLRT-----LTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA------ 318

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528492384 310 qDPYLLRTVPCKVSEGSRIALSPDGRVVAI-SNVCDIAMYNATTGELEEEFhSVHNGEITDLKFDINNRFLLSTG-DRVI 387
Cdd:COG2319  319 -TGKLLRTLTGHTGAVRSVAFSPDGKTLASgSDDGTVRLWDLATGELLRTL-TGHTGAVTSVAFSPDGRTLASGSaDGTV 396


                 ..
gi 528492384 388 RV 389
Cdd:COG2319  397 RL 398
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 76-390 4.39e-33

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 126.30  E-value: 4.39e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528492384  76 LASALKSHSGHVTCLDFSSNGKYLASCSDDRTIRIWSTKDflDRDHKCLRANIEFDHAtlVRFSPDSRAFITwLANGETI 155
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLET--GELLRTLKGHTGPVRD--VAASADGTYLAS-GSSDKTI 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528492384 156 RIYKmVKKDDGTFNFKAapgdfpqkHKGVIINIGIAETGKFIMSASVDTTIVIWDL-KGEVLATINTNQMTNSHAAVSPC 234
Cdd:cd00200   76 RLWD-LETGECVRTLTG--------HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVeTGKCLTTLRGHTDWVNSVAFSPD 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528492384 235 GRFVASCGFTPDVKVWEVcfgKSGEFREVarafdLKGHSAGVYSFDFSNDSRRMVTVSKDGTWKLWDTDveyKKKQdpyl 314
Cdd:cd00200  147 GTFVASSSQDGTIKLWDL---RTGKCVAT-----LTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS---TGKC---- 211

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 528492384 315 LRTVPCKVSEGSRIALSPDGRVVAISNV-CDIAMYNATTGELEEEFHSvHNGEITDLKFDINNRFLLSTG-DRVIRVF 390
Cdd:cd00200  212 LGTLRGHENGVNSVAFSPDGYLLASGSEdGTIRVWDLRTGECVQTLSG-HTNSVTSLAWSPDGKRLASGSaDGTIRIW 288
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 80-112 4.76e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 54.63  E-value: 4.76e-10
                           10        20        30
                   ....*....|....*....|....*....|...
gi 528492384    80 LKSHSGHVTCLDFSSNGKYLASCSDDRTIRIWS 112
Cdd:smart00320   8 LKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
80-112 7.88e-10

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 53.89  E-value: 7.88e-10
                          10        20        30
                  ....*....|....*....|....*....|...
gi 528492384   80 LKSHSGHVTCLDFSSNGKYLASCSDDRTIRIWS 112
Cdd:pfam00400   7 LEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
72-389 8.44e-47

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 166.24  E-value: 8.44e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528492384  72 THQLLASALKSHSGHVTCLDFSSNGKYLASCSDDRTIRIWSTkdfldRDHKCLRA-NIEFDHATLVRFSPDSRAFITWLA 150
Cdd:COG2319  108 ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL-----ATGKLLRTlTGHSGAVTSVAFSPDGKLLASGSD 182

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528492384 151 NGeTIRIYKmVKKDDGTFNFKAapgdfpqkHKGVIINIGIAETGKFIMSASVDTTIVIWDLK-GEVLATINTNQMTNSHA 229
Cdd:COG2319  183 DG-TVRLWD-LATGKLLRTLTG--------HTGAVRSVAFSPDGKLLASGSADGTVRLWDLAtGKLLRTLTGHSGSVRSV 252

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528492384 230 AVSPCGRFVASCGFTPDVKVWEVcfgKSGEFREVarafdLKGHSAGVYSFDFSNDSRRMVTVSKDGTWKLWDTDveykkk 309
Cdd:COG2319  253 AFSPDGRLLASGSADGTVRLWDL---ATGELLRT-----LTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA------ 318

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528492384 310 qDPYLLRTVPCKVSEGSRIALSPDGRVVAI-SNVCDIAMYNATTGELEEEFhSVHNGEITDLKFDINNRFLLSTG-DRVI 387
Cdd:COG2319  319 -TGKLLRTLTGHTGAVRSVAFSPDGKTLASgSDDGTVRLWDLATGELLRTL-TGHTGAVTSVAFSPDGRTLASGSaDGTV 396


                 ..
gi 528492384 388 RV 389
Cdd:COG2319  397 RL 398
WD40 COG2319
WD40 repeat [General function prediction only];
72-303 1.52e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 132.73  E-value: 1.52e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528492384  72 THQLLASaLKSHSGHVTCLDFSSNGKYLASCSDDRTIRIWSTkdfldRDHKCLRaniEFDHATL----VRFSPDSRAFIT 147
Cdd:COG2319  193 TGKLLRT-LTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDL-----ATGKLLR---TLTGHSGsvrsVAFSPDGRLLAS 263

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528492384 148 WLANGeTIRIYKMvkkDDGtfnfkaAPGDFPQKHKGVIINIGIAETGKFIMSASVDTTIVIWDLK-GEVLATINTNQMTN 226
Cdd:COG2319  264 GSADG-TVRLWDL---ATG------ELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLAtGKLLRTLTGHTGAV 333

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 528492384 227 SHAAVSPCGRFVASCGFTPDVKVWEVcfgKSGEFREVarafdLKGHSAGVYSFDFSNDSRRMVTVSKDGTWKLWDTD 303
Cdd:COG2319  334 RSVAFSPDGKTLASGSDDGTVRLWDL---ATGELLRT-----LTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 76-390 4.39e-33

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 126.30  E-value: 4.39e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528492384  76 LASALKSHSGHVTCLDFSSNGKYLASCSDDRTIRIWSTKDflDRDHKCLRANIEFDHAtlVRFSPDSRAFITwLANGETI 155
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLET--GELLRTLKGHTGPVRD--VAASADGTYLAS-GSSDKTI 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528492384 156 RIYKmVKKDDGTFNFKAapgdfpqkHKGVIINIGIAETGKFIMSASVDTTIVIWDL-KGEVLATINTNQMTNSHAAVSPC 234
Cdd:cd00200   76 RLWD-LETGECVRTLTG--------HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVeTGKCLTTLRGHTDWVNSVAFSPD 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528492384 235 GRFVASCGFTPDVKVWEVcfgKSGEFREVarafdLKGHSAGVYSFDFSNDSRRMVTVSKDGTWKLWDTDveyKKKQdpyl 314
Cdd:cd00200  147 GTFVASSSQDGTIKLWDL---RTGKCVAT-----LTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS---TGKC---- 211

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 528492384 315 LRTVPCKVSEGSRIALSPDGRVVAISNV-CDIAMYNATTGELEEEFHSvHNGEITDLKFDINNRFLLSTG-DRVIRVF 390
Cdd:cd00200  212 LGTLRGHENGVNSVAFSPDGYLLASGSEdGTIRVWDLRTGECVQTLSG-HTNSVTSLAWSPDGKRLASGSaDGTIRIW 288
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 76-301 3.27e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 112.81  E-value: 3.27e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528492384  76 LASALKSHSGHVTCLDFSSNGKYLASCSDDRTIRIWSTKDFldrdhKCLRAniEFDH---ATLVRFSPDSRaFITWLANG 152
Cdd:cd00200   85 CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETG-----KCLTT--LRGHtdwVNSVAFSPDGT-FVASSSQD 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528492384 153 ETIRIYkmvkkDDGTFNFKAapgDFPQkHKGVIINIGIAETGKFIMSASVDTTIVIWDLK-GEVLATINTNQMTNSHAAV 231
Cdd:cd00200  157 GTIKLW-----DLRTGKCVA---TLTG-HTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLStGKCLGTLRGHENGVNSVAF 227

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528492384 232 SPCGRFVASCGFTPDVKVWEVCFGKsgefrevaRAFDLKGHSAGVYSFDFSNDSRRMVTVSKDGTWKLWD 301
Cdd:cd00200  228 SPDGYLLASGSEDGTIRVWDLRTGE--------CVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
181-395 2.76e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 86.12  E-value: 2.76e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528492384 181 HKGVIINIGIAETGKFIMSASVDTTIVIWDL-KGEVLATINTNQMTNSHAAVSPCGRFVASCGFTPDVKVWEV------- 252
Cdd:COG2319   35 LAAAVASLAASPDGARLAAGAGDLTLLLLDAaAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLatglllr 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528492384 253 -CFGKSGEFREVA-----------------RAFD---------LKGHSAGVYSFDFSNDSRRMVTVSKDGTWKLWDTDve 305
Cdd:COG2319  115 tLTGHTGAVRSVAfspdgktlasgsadgtvRLWDlatgkllrtLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLA-- 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528492384 306 ykkkqDPYLLRTVPCKVSEGSRIALSPDGRVVAISNVcD--IAMYNATTGELEEEFHSvHNGEITDLKFDINNRFLLSTG 383
Cdd:COG2319  193 -----TGKLLRTLTGHTGAVRSVAFSPDGKLLASGSA-DgtVRLWDLATGKLLRTLTG-HSGSVRSVAFSPDGRLLASGS 265

                        250
                 ....*....|...
gi 528492384 384 -DRVIRVFHNVTG 395
Cdd:COG2319  266 aDGTVRLWDLATG 278
WD40 COG2319
WD40 repeat [General function prediction only];
72-213 3.14e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 76.87  E-value: 3.14e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528492384  72 THQLLASaLKSHSGHVTCLDFSSNGKYLASCSDDRTIRIWSTKDfldrdHKCLRA-NIEFDHATLVRFSPDSRAFITWLA 150
Cdd:COG2319  277 TGELLRT-LTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLAT-----GKLLRTlTGHTGAVRSVAFSPDGKTLASGSD 350

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 528492384 151 NGeTIRIYKMvkkDDGTfnfkaaPGDFPQKHKGVIINIGIAETGKFIMSASVDTTIVIWDLKG 213
Cdd:COG2319  351 DG-TVRLWDL---ATGE------LLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
199-395 1.86e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 65.32  E-value: 1.86e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528492384 199 SASVDTTIVIWDLK-GEVLATINTNQMTNSHAAVSPCGRFVASCGFTPDVKVWEVcfgksgefREVARAFDLKGHSAGVY 277
Cdd:COG2319   11 AASADLALALLAAAlGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDA--------AAGALLATLLGHTAAVL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528492384 278 SFDFSNDSRRMVTVSKDGTWKLWDTDveykkkqDPYLLRTVPCKVSEGSRIALSPDGRVVAI-SNVCDIAMYNATTGELE 356
Cdd:COG2319   83 SVAFSPDGRLLASASADGTVRLWDLA-------TGLLLRTLTGHTGAVRSVAFSPDGKTLASgSADGTVRLWDLATGKLL 155

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 528492384 357 EEFHSvHNGEITDLKFDINNRFLLSTG-DRVIRVFHNVTG 395
Cdd:COG2319  156 RTLTG-HSGAVTSVAFSPDGKLLASGSdDGTVRLWDLATG 194
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 80-112 4.76e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 54.63  E-value: 4.76e-10
                           10        20        30
                   ....*....|....*....|....*....|...
gi 528492384    80 LKSHSGHVTCLDFSSNGKYLASCSDDRTIRIWS 112
Cdd:smart00320   8 LKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
80-112 7.88e-10

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 53.89  E-value: 7.88e-10
                          10        20        30
                  ....*....|....*....|....*....|...
gi 528492384   80 LKSHSGHVTCLDFSSNGKYLASCSDDRTIRIWS 112
Cdd:pfam00400   7 LEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 269-301 2.58e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.92  E-value: 2.58e-07
                           10        20        30
                   ....*....|....*....|....*....|...
gi 528492384   269 LKGHSAGVYSFDFSNDSRRMVTVSKDGTWKLWD 301
Cdd:smart00320   8 LKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
269-301 1.65e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.64  E-value: 1.65e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 528492384  269 LKGHSAGVYSFDFSNDSRRMVTVSKDGTWKLWD 301
Cdd:pfam00400   7 LEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 196-354 4.30e-04

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 40.81  E-value: 4.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528492384 196 FIMSASVDTTIVIWDLKGEVLATINTNQMTNSHAAVSPCGR---FVASCGFTPDVKVWEVcfgKSGEFREVARAfdlkgh 272
Cdd:COG0823    3 FTLSRDGNSDIYVVDLDGGEPRRLTNSPGIDTSPAWSPDGRriaFTSDRGGGPQIYVVDA---DGGEPRRLTFG------ 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528492384 273 SAGVYSFDFSNDSRRMVTVS-KDGTWKLWDTDVEykkkqdpyllRTVPCKVSEGSR-IALSPDGRVVAIS----NVCDIA 346
Cdd:COG0823   74 GGYNASPSWSPDGKRLAFVSrSDGRFDIYVLDLD----------GGAPRRLTDGPGsPSWSPDGRRIVFSsdrgGRPDLY 143


                 ....*...
gi 528492384 347 MYNATTGE 354
Cdd:COG0823  144 VVDLDGRK 151
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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