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Conserved domains on  [gi|2025761542|ref|XP_005084325|]
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ADAMTS-like protein 4 isoform X1 [Mesocricetus auratus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 453-566 7.84e-30

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


:

Pssm-ID: 461796  Cd Length: 115  Bit Score: 114.60  E-value: 7.84e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025761542  453 LVSGNLTdRGGPLGYQKILWIPAGASRLQISQLRPSSNYLALRGPGGRSIINGNWAVDP-PGSYSAIGTVFQYNRPPREe 531
Cdd:pfam05986    1 TVSGSFT-EGRAKGYVTFVTIPAGATHIHIVNRKPSFTHLAVKNVQGKYILNGKGSISLnPTYPSLLGTVLEYRRSLPA- 78

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 2025761542  532 gkGESLSAQGPTTQPVDVYMIFQED---NPGVFYQYVI 566
Cdd:pfam05986   79 --LEELHAPGPTQEDLEIQVLRQYGkgtNPGITYEYFI 114
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 694-750 1.63e-14

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 68.63  E-value: 1.63e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2025761542  694 WEAGEWTSCSRSCGPGTQQRQLLCRQEfgDGGSSVPPERCGHLPRPNITQPCQLRLC 750
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQK--GGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 881-937 6.76e-14

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 67.09  E-value: 6.76e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2025761542  881 WYTGPWSECSSECGSGTQHRDVICVSKLGAEfnVTPPSNCSHLPRPPALQPCQGQAC 937
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGS--IVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 812-875 1.18e-10

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 57.85  E-value: 1.18e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2025761542  812 WFYSDWSSkCSAECGTGIQRRSVVCLRSGEtlqehqeaGAESAEHGCPLRSRPPDMRACSLGPC 875
Cdd:pfam19030    1 WVAGPWGE-CSVTCGGGVQTRLVQCVQKGG--------GSIVPDSECSAQKKPPETQSCNLKPC 55
PLAC pfam08686
PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short ...
 1000-1029 2.11e-10

PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short six-cysteine region that is usually found at the C terminal of proteins. It is found in a range of proteins including PACE4 (paired basic amino acid cleaving enzyme 4) and the extracellular matrix protein lacunin.


:

Pssm-ID: 462560  Cd Length: 31  Bit Score: 56.39  E-value: 2.11e-10
                           10        20        30
                   ....*....|....*....|....*....|
gi 2025761542 1000 CKDSSPHCPLVVQARLCVYPYYTATCCRSC 1029
Cdd:pfam08686    1 CKDKFANCSLVVQARLCSHKYYRQFCCRSC 30
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 941-992 2.45e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 54.00  E-value: 2.45e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2025761542  941 WFSTLWSPCSRSCQGGMQTREVQC---LSANQTLGTRCPPRLRPSRKRSCNSQPC 992
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCvqkGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 758-808 4.90e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 50.53  E-value: 4.90e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2025761542  758 PWGQCSVRCGRGQRNRQVRCVGSDGDEVSSQECASGPPPPPSREACDMGPC 808
Cdd:pfam19030    5 PWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKPPETQSCNLKPC 55
dnaA super family cl42516
chromosomal replication initiator protein DnaA;
104-287 7.42e-06

chromosomal replication initiator protein DnaA;


The actual alignment was detected with superfamily member PRK14086:

Pssm-ID: 455861 [Multi-domain]  Cd Length: 617  Bit Score: 49.82  E-value: 7.42e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025761542  104 PQSPHRPQPRgrggpLQGPASHLGREKTQETQGTQRSwgrDPIRPGMFGYGRAPFALPLHRSRRHPSRPSQ--PKNSSAG 181
Cdd:PRK14086    95 PAPPPPHARR-----TSEPELPRPGRRPYEGYGGPRA---DDRPPGLPRQDQLPTARPAYPAYQQRPEPGAwpRAADDYG 166

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025761542  182 AEAFPSQ-PPSAEPPSANRSSPVQ----------LPELHARSPPAETPRTGSTQtevsprssPAHSDTGTPSPMSFFG-D 249
Cdd:PRK14086   167 WQQQRLGfPPRAPYASPASYAPEQerdrepydagRPEYDQRRRDYDHPRPDWDR--------PRRDRTDRPEPPPGAGhV 238

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 2025761542  250 SRSFQGSP----RPRMPASQGWNSPQGAERRPHPFPSVPWSR 287
Cdd:PRK14086   239 HRGGPGPPerddAPVVPIRPSAPGPLAAQPAPAPGPGEPTAR 280
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 46-70 1.77e-05

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 42.96  E-value: 1.77e-05
                            10        20
                    ....*....|....*....|....*
gi 2025761542    46 WGHWSPWASCSQPCGVGVQRRSRTC 70
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSC 25
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 641-690 1.01e-04

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 40.90  E-value: 1.01e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 2025761542  641 SECSASCGKGVWRPVFLCISRESGEELDEQSCAMGARPPASaEPCHGPPC 690
Cdd:pfam19030    7 GECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKPPET-QSCNLKPC 55
ADAMTS_CR_3 super family cl41950
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 357-451 2.79e-04

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


The actual alignment was detected with superfamily member pfam19236:

Pssm-ID: 437068  Cd Length: 115  Bit Score: 41.62  E-value: 2.79e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025761542  357 QCAAFDSQEFM-----GQLYQW-EPFTEVQGSQRCELNCRPRGFRFYVRHTEKVQDGTLCQP------GSLDICVAGRCL 424
Cdd:pfam19236    9 QCARTDGQPLRsspggASFYHWgAAVPHSQGDALCRHMCRAIGESFIMKRGDSFLDGTRCMPsgpredGTLSLCVLGSCR 88

                           90       100
                   ....*....|....*....|....*..
gi 2025761542  425 SPGCDGILGSGRRPDGCGVCGGDGSTC 451
Cdd:pfam19236   89 TFGCDGRMDSQQVWDRCQVCGGDNSTC 115
 
Name Accession Description Interval E-value
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 453-566 7.84e-30

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


Pssm-ID: 461796  Cd Length: 115  Bit Score: 114.60  E-value: 7.84e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025761542  453 LVSGNLTdRGGPLGYQKILWIPAGASRLQISQLRPSSNYLALRGPGGRSIINGNWAVDP-PGSYSAIGTVFQYNRPPREe 531
Cdd:pfam05986    1 TVSGSFT-EGRAKGYVTFVTIPAGATHIHIVNRKPSFTHLAVKNVQGKYILNGKGSISLnPTYPSLLGTVLEYRRSLPA- 78

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 2025761542  532 gkGESLSAQGPTTQPVDVYMIFQED---NPGVFYQYVI 566
Cdd:pfam05986   79 --LEELHAPGPTQEDLEIQVLRQYGkgtNPGITYEYFI 114
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 694-750 1.63e-14

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 68.63  E-value: 1.63e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2025761542  694 WEAGEWTSCSRSCGPGTQQRQLLCRQEfgDGGSSVPPERCGHLPRPNITQPCQLRLC 750
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQK--GGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 881-937 6.76e-14

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 67.09  E-value: 6.76e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2025761542  881 WYTGPWSECSSECGSGTQHRDVICVSKLGAEfnVTPPSNCSHLPRPPALQPCQGQAC 937
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGS--IVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 812-875 1.18e-10

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 57.85  E-value: 1.18e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2025761542  812 WFYSDWSSkCSAECGTGIQRRSVVCLRSGEtlqehqeaGAESAEHGCPLRSRPPDMRACSLGPC 875
Cdd:pfam19030    1 WVAGPWGE-CSVTCGGGVQTRLVQCVQKGG--------GSIVPDSECSAQKKPPETQSCNLKPC 55
PLAC pfam08686
PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short ...
 1000-1029 2.11e-10

PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short six-cysteine region that is usually found at the C terminal of proteins. It is found in a range of proteins including PACE4 (paired basic amino acid cleaving enzyme 4) and the extracellular matrix protein lacunin.


Pssm-ID: 462560  Cd Length: 31  Bit Score: 56.39  E-value: 2.11e-10
                           10        20        30
                   ....*....|....*....|....*....|
gi 2025761542 1000 CKDSSPHCPLVVQARLCVYPYYTATCCRSC 1029
Cdd:pfam08686    1 CKDKFANCSLVVQARLCSHKYYRQFCCRSC 30
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 941-992 2.45e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 54.00  E-value: 2.45e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2025761542  941 WFSTLWSPCSRSCQGGMQTREVQC---LSANQTLGTRCPPRLRPSRKRSCNSQPC 992
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCvqkGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 758-808 4.90e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 50.53  E-value: 4.90e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2025761542  758 PWGQCSVRCGRGQRNRQVRCVGSDGDEVSSQECASGPPPPPSREACDMGPC 808
Cdd:pfam19030    5 PWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKPPETQSCNLKPC 55
dnaA PRK14086
chromosomal replication initiator protein DnaA;
104-287 7.42e-06

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 49.82  E-value: 7.42e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025761542  104 PQSPHRPQPRgrggpLQGPASHLGREKTQETQGTQRSwgrDPIRPGMFGYGRAPFALPLHRSRRHPSRPSQ--PKNSSAG 181
Cdd:PRK14086    95 PAPPPPHARR-----TSEPELPRPGRRPYEGYGGPRA---DDRPPGLPRQDQLPTARPAYPAYQQRPEPGAwpRAADDYG 166

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025761542  182 AEAFPSQ-PPSAEPPSANRSSPVQ----------LPELHARSPPAETPRTGSTQtevsprssPAHSDTGTPSPMSFFG-D 249
Cdd:PRK14086   167 WQQQRLGfPPRAPYASPASYAPEQerdrepydagRPEYDQRRRDYDHPRPDWDR--------PRRDRTDRPEPPPGAGhV 238

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 2025761542  250 SRSFQGSP----RPRMPASQGWNSPQGAERRPHPFPSVPWSR 287
Cdd:PRK14086   239 HRGGPGPPerddAPVVPIRPSAPGPLAAQPAPAPGPGEPTAR 280
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 46-70 1.77e-05

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 42.96  E-value: 1.77e-05
                            10        20
                    ....*....|....*....|....*
gi 2025761542    46 WGHWSPWASCSQPCGVGVQRRSRTC 70
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSC 25
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 946-992 3.66e-05

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 42.19  E-value: 3.66e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*...
gi 2025761542   946 WSPCSRSCQGGMQTREVQCLSANQTL-GTRCPPRLRpsRKRSCNSQPC 992
Cdd:smart00209    7 WSPCSVTCGGGVQTRTRSCCSPPPQNgGGPCTGEDV--ETRACNEQPC 52
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 641-690 1.01e-04

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 40.90  E-value: 1.01e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 2025761542  641 SECSASCGKGVWRPVFLCISRESGEELDEQSCAMGARPPASaEPCHGPPC 690
Cdd:pfam19030    7 GECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKPPET-QSCNLKPC 55
ADAMTS_CR_3 pfam19236
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 357-451 2.79e-04

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


Pssm-ID: 437068  Cd Length: 115  Bit Score: 41.62  E-value: 2.79e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025761542  357 QCAAFDSQEFM-----GQLYQW-EPFTEVQGSQRCELNCRPRGFRFYVRHTEKVQDGTLCQP------GSLDICVAGRCL 424
Cdd:pfam19236    9 QCARTDGQPLRsspggASFYHWgAAVPHSQGDALCRHMCRAIGESFIMKRGDSFLDGTRCMPsgpredGTLSLCVLGSCR 88

                           90       100
                   ....*....|....*....|....*..
gi 2025761542  425 SPGCDGILGSGRRPDGCGVCGGDGSTC 451
Cdd:pfam19236   89 TFGCDGRMDSQQVWDRCQVCGGDNSTC 115
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 49-69 6.42e-04

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 38.41  E-value: 6.42e-04
                           10        20
                   ....*....|....*....|.
gi 2025761542   49 WSPWASCSQPCGVGVQRRSRT 69
Cdd:pfam19028    6 WSEWSECSVTCGGGVQTRTRT 26
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 165-351 8.24e-04

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 43.49  E-value: 8.24e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025761542  165 SRRHPSRPSQPKNSSAGAEAFPSQPPSAEPPSANR----------SSPVQLPELHARSPPAETPRTGSTQTEVSPRSSPA 234
Cdd:pfam09770  103 NRQQPAARAAQSSAQPPASSLPQYQYASQQSQQPSkpvrtgyekyKEPEPIPDLQVDASLWGVAPKKAAAPAPAPQPAAQ 182

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025761542  235 HSDTGTPSP--MSF--FGDSRSFQGSPRPRMPASQGWNSPQGAERRPHPFP-SVPWSRGQQSRGHGRPRESSHGFPDGWL 309
Cdd:pfam09770  183 PASLPAPSRkmMSLeeVEAAMRAQAKKPAQQPAPAPAQPPAAPPAQQAQQQqQFPPQIQQQQQPQQQPQQPQQHPGQGHP 262

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....
gi 2025761542  310 P--LTRDSSPlwslfAPNSPVPNCSGENEQLRacSQEPCPPEQP 351
Cdd:pfam09770  263 VtiLQRPQSP-----QPDPAQPSIQPQAQQFH--QQPPPVPVQP 299
rad23 TIGR00601
UV excision repair protein Rad23; All proteins in this family for which functions are known ...
 173-245 1.52e-03

UV excision repair protein Rad23; All proteins in this family for which functions are known are components of a multiprotein complex used for targeting nucleotide excision repair to specific parts of the genome. In humans, Rad23 complexes with the XPC protein. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273167 [Multi-domain]  Cd Length: 378  Bit Score: 42.19  E-value: 1.52e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2025761542  173 SQPKNSSAGAEAFPSQPPSAEPPSanrSSPVQLPELHARSPPAETPRTGSTQTEVSPRSSPAHSDTGTPSPMS 245
Cdd:TIGR00601   75 SKPKTGTGKVAPPAATPTSAPTPT---PSPPASPASGMSAAPASAVEEKSPSEESATATAPESPSTSVPSSGS 144
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 694-750 4.42e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 36.41  E-value: 4.42e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 2025761542   694 WEAGEWTSCSRSCGPGTQQRQLLCRqefgDGGSSVPPERCGHLPRpnITQPCQLRLC 750
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCC----SPPPQNGGGPCTGEDV--ETRACNEQPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 750-808 9.74e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 35.26  E-value: 9.74e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 2025761542   750 CGHWkisSPWGQCSVRCGRGQRNRQVRCVGSDGDeVSSQECasgPPPPPSREACDMGPC 808
Cdd:smart00209    1 WSEW---SEWSPCSVTCGGGVQTRTRSCCSPPPQ-NGGGPC---TGEDVETRACNEQPC 52
 
Name Accession Description Interval E-value
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 453-566 7.84e-30

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


Pssm-ID: 461796  Cd Length: 115  Bit Score: 114.60  E-value: 7.84e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025761542  453 LVSGNLTdRGGPLGYQKILWIPAGASRLQISQLRPSSNYLALRGPGGRSIINGNWAVDP-PGSYSAIGTVFQYNRPPREe 531
Cdd:pfam05986    1 TVSGSFT-EGRAKGYVTFVTIPAGATHIHIVNRKPSFTHLAVKNVQGKYILNGKGSISLnPTYPSLLGTVLEYRRSLPA- 78

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 2025761542  532 gkGESLSAQGPTTQPVDVYMIFQED---NPGVFYQYVI 566
Cdd:pfam05986   79 --LEELHAPGPTQEDLEIQVLRQYGkgtNPGITYEYFI 114
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 694-750 1.63e-14

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 68.63  E-value: 1.63e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2025761542  694 WEAGEWTSCSRSCGPGTQQRQLLCRQEfgDGGSSVPPERCGHLPRPNITQPCQLRLC 750
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQK--GGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 881-937 6.76e-14

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 67.09  E-value: 6.76e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2025761542  881 WYTGPWSECSSECGSGTQHRDVICVSKLGAEfnVTPPSNCSHLPRPPALQPCQGQAC 937
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGS--IVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 812-875 1.18e-10

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 57.85  E-value: 1.18e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2025761542  812 WFYSDWSSkCSAECGTGIQRRSVVCLRSGEtlqehqeaGAESAEHGCPLRSRPPDMRACSLGPC 875
Cdd:pfam19030    1 WVAGPWGE-CSVTCGGGVQTRLVQCVQKGG--------GSIVPDSECSAQKKPPETQSCNLKPC 55
PLAC pfam08686
PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short ...
 1000-1029 2.11e-10

PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short six-cysteine region that is usually found at the C terminal of proteins. It is found in a range of proteins including PACE4 (paired basic amino acid cleaving enzyme 4) and the extracellular matrix protein lacunin.


Pssm-ID: 462560  Cd Length: 31  Bit Score: 56.39  E-value: 2.11e-10
                           10        20        30
                   ....*....|....*....|....*....|
gi 2025761542 1000 CKDSSPHCPLVVQARLCVYPYYTATCCRSC 1029
Cdd:pfam08686    1 CKDKFANCSLVVQARLCSHKYYRQFCCRSC 30
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 941-992 2.45e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 54.00  E-value: 2.45e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2025761542  941 WFSTLWSPCSRSCQGGMQTREVQC---LSANQTLGTRCPPRLRPSRKRSCNSQPC 992
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCvqkGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 758-808 4.90e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 50.53  E-value: 4.90e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2025761542  758 PWGQCSVRCGRGQRNRQVRCVGSDGDEVSSQECASGPPPPPSREACDMGPC 808
Cdd:pfam19030    5 PWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKPPETQSCNLKPC 55
dnaA PRK14086
chromosomal replication initiator protein DnaA;
104-287 7.42e-06

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 49.82  E-value: 7.42e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025761542  104 PQSPHRPQPRgrggpLQGPASHLGREKTQETQGTQRSwgrDPIRPGMFGYGRAPFALPLHRSRRHPSRPSQ--PKNSSAG 181
Cdd:PRK14086    95 PAPPPPHARR-----TSEPELPRPGRRPYEGYGGPRA---DDRPPGLPRQDQLPTARPAYPAYQQRPEPGAwpRAADDYG 166

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025761542  182 AEAFPSQ-PPSAEPPSANRSSPVQ----------LPELHARSPPAETPRTGSTQtevsprssPAHSDTGTPSPMSFFG-D 249
Cdd:PRK14086   167 WQQQRLGfPPRAPYASPASYAPEQerdrepydagRPEYDQRRRDYDHPRPDWDR--------PRRDRTDRPEPPPGAGhV 238

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 2025761542  250 SRSFQGSP----RPRMPASQGWNSPQGAERRPHPFPSVPWSR 287
Cdd:PRK14086   239 HRGGPGPPerddAPVVPIRPSAPGPLAAQPAPAPGPGEPTAR 280
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 46-70 1.77e-05

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 42.96  E-value: 1.77e-05
                            10        20
                    ....*....|....*....|....*
gi 2025761542    46 WGHWSPWASCSQPCGVGVQRRSRTC 70
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSC 25
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 946-992 3.66e-05

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 42.19  E-value: 3.66e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*...
gi 2025761542   946 WSPCSRSCQGGMQTREVQCLSANQTL-GTRCPPRLRpsRKRSCNSQPC 992
Cdd:smart00209    7 WSPCSVTCGGGVQTRTRSCCSPPPQNgGGPCTGEDV--ETRACNEQPC 52
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 946-992 8.71e-05

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 41.11  E-value: 8.71e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 2025761542  946 WSPCSRSCQGGMQTREVQCLSANQTLGTRCPPRLrpsRKRSCNSQPC 992
Cdd:pfam19028    9 WSECSVTCGGGVQTRTRTVIVEPQNGGRPCPELL---ERRPCNLPPC 52
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 641-690 1.01e-04

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 40.90  E-value: 1.01e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 2025761542  641 SECSASCGKGVWRPVFLCISRESGEELDEQSCAMGARPPASaEPCHGPPC 690
Cdd:pfam19030    7 GECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKPPET-QSCNLKPC 55
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 90-284 1.16e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 46.13  E-value: 1.16e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025761542   90 RPRGQSSRPQVSRGPQSPHRPQPRGRGGPLQGPASHLGREKTQETQGTQRSWGRDPIRPGMFGYGRAPFALPLHRSRRHP 169
Cdd:PRK07764   607 GPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPA 686

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025761542  170 SRPSQPknSSAGAEAFPSQPPSAEPPSANRSSPvqlpelhaRSPPAETPRTGSTQTEVSPRSSPAHSDTGTPSpmsfFGD 249
Cdd:PRK07764   687 PAAPAA--PAGAAPAQPAPAPAATPPAGQADDP--------AAQPPQAAQGASAPSPAADDPVPLPPEPDDPP----DPA 752

                          170       180       190
                   ....*....|....*....|....*....|....*
gi 2025761542  250 SRSFQGSPRPRMPASQGWNSPQGAERRPHPFPSVP 284
Cdd:PRK07764   753 GAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEMAE 787
ADAMTS_CR_3 pfam19236
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 357-451 2.79e-04

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


Pssm-ID: 437068  Cd Length: 115  Bit Score: 41.62  E-value: 2.79e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025761542  357 QCAAFDSQEFM-----GQLYQW-EPFTEVQGSQRCELNCRPRGFRFYVRHTEKVQDGTLCQP------GSLDICVAGRCL 424
Cdd:pfam19236    9 QCARTDGQPLRsspggASFYHWgAAVPHSQGDALCRHMCRAIGESFIMKRGDSFLDGTRCMPsgpredGTLSLCVLGSCR 88

                           90       100
                   ....*....|....*....|....*..
gi 2025761542  425 SPGCDGILGSGRRPDGCGVCGGDGSTC 451
Cdd:pfam19236   89 TFGCDGRMDSQQVWDRCQVCGGDNSTC 115
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 49-69 6.42e-04

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 38.41  E-value: 6.42e-04
                           10        20
                   ....*....|....*....|.
gi 2025761542   49 WSPWASCSQPCGVGVQRRSRT 69
Cdd:pfam19028    6 WSEWSECSVTCGGGVQTRTRT 26
PHA03247 PHA03247
large tegument protein UL36; Provisional
 56-355 6.44e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.16  E-value: 6.44e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025761542   56 SQPCGVGVQRRSRTCELRPGLPLPPRPPrhpealRPRgqSSRPQVSRGPQSPHRPQPrgrgGPLQGPASHLGREKTQETQ 135
Cdd:PHA03247  2656 PAPGRVSRPRRARRLGRAAQASSPPQRP------RRR--AARPTVGSLTSLADPPPP----PPTPEPAPHALVSATPLPP 2723

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025761542  136 GTQRSWGRDPIRPGMFGYGRAPFALPLHRSRRHPSRPSQPKN--SSAGAEAFPSQPPSAEPPSANRSSPVQLPELHARSP 213
Cdd:PHA03247  2724 GPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGppAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWD 2803

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025761542  214 PAETPRTGSTQTE-VSPRSSPAhsdTGTPSPMSFFGDSRSFQGSPRPRMPASQGWNSPQGAERRPHP---------FPSV 283
Cdd:PHA03247  2804 PADPPAAVLAPAAaLPPAASPA---GPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPsrspaakpaAPAR 2880

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2025761542  284 PWSRGQQSRGHGRPRESSHGFPDGWLPLTRDSSPLWSLFAPNSPVPNCSGENEQLRACSQEPCPPeQPDPRA 355
Cdd:PHA03247  2881 PPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAP-TTDPAG 2951
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 165-351 8.24e-04

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 43.49  E-value: 8.24e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025761542  165 SRRHPSRPSQPKNSSAGAEAFPSQPPSAEPPSANR----------SSPVQLPELHARSPPAETPRTGSTQTEVSPRSSPA 234
Cdd:pfam09770  103 NRQQPAARAAQSSAQPPASSLPQYQYASQQSQQPSkpvrtgyekyKEPEPIPDLQVDASLWGVAPKKAAAPAPAPQPAAQ 182

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025761542  235 HSDTGTPSP--MSF--FGDSRSFQGSPRPRMPASQGWNSPQGAERRPHPFP-SVPWSRGQQSRGHGRPRESSHGFPDGWL 309
Cdd:pfam09770  183 PASLPAPSRkmMSLeeVEAAMRAQAKKPAQQPAPAPAQPPAAPPAQQAQQQqQFPPQIQQQQQPQQQPQQPQQHPGQGHP 262

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....
gi 2025761542  310 P--LTRDSSPlwslfAPNSPVPNCSGENEQLRacSQEPCPPEQP 351
Cdd:pfam09770  263 VtiLQRPQSP-----QPDPAQPSIQPQAQQFH--QQPPPVPVQP 299
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 47-245 8.28e-04

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 43.41  E-value: 8.28e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025761542   47 GHWSPWASCSQPCGVGVQRRSRtcELRPGLPLPPRPPRHPEALRPRGQSSRPQVSRGPQSPHRPQPRGRGGPLQGPASHL 126
Cdd:PTZ00441   241 GPWDEWTPCSVTCGKGTHSRSR--PILHEGCTTHMVEECEEEECPVEPEPLPVPAPVPPTPEDDNPRPTDDEFAVPNFNE 318

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025761542  127 GREKTQETQgtqrswgrDPIRPGMFGYGRAPFALPLH---------RSRRHPSRPSQPKNSSAGAEAFPSQPPSAEPPSA 197
Cdd:PTZ00441   319 GLDVPDNPQ--------DPVPPPNEGKDGNPNEENLFppgddevpdESNVPPNPPNVPGGSNSEFSSDVENPPNPPNPDI 390

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 2025761542  198 NRSSPvQLPELHARSPPAETPRTG--STQTEVSPRSSPAHSDTGTPSPMS 245
Cdd:PTZ00441   391 PEQEP-NIPEDSNKEVPEDVPMEPedDRDNNFNEPKKPENKGDGQNEPVI 439
PHA03247 PHA03247
large tegument protein UL36; Provisional
 155-355 9.02e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.39  E-value: 9.02e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025761542  155 RAPFALPLHRSRRHPSRPSQPKNSSAgAEAFPSQPPSAEPPSANRSSPVQLPELHARSPPAETPrtgstQTEVSPRSSPA 234
Cdd:PHA03247  2869 RSPAAKPAAPARPPVRRLARPAVSRS-TESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQP-----PPPPPPRPQPP 2942

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025761542  235 HSDTGTPSPMSffgdsRSFQGSPRPRMPASQGWNSPQGAERRPHPFPSV--PWSRGQQSRGHGRPRESShgfpdgW---L 309
Cdd:PHA03247  2943 LAPTTDPAGAG-----EPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSReaPASSTPPLTGHSLSRVSS------WassL 3011

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2025761542  310 PLTRDSSP-----LWSLFAPN-----SPVPNCSGENEQLRACSQEPCPPEQPDPRA 355
Cdd:PHA03247  3012 ALHEETDPppvslKQTLWPPDdtedsDADSLFDSDSERSDLEALDPLPPEPHDPFA 3067
TSP_1 pfam00090
Thrombospondin type 1 domain;
47-70 1.15e-03

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 37.78  E-value: 1.15e-03
                           10        20
                   ....*....|....*....|....
gi 2025761542   47 GHWSPWASCSQPCGVGVQRRSRTC 70
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTC 24
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 172-277 1.49e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 42.67  E-value: 1.49e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025761542  172 PSQPKNSSAGAEAFPSQPP-SAEPPSANRSSPVQLPELHARSPPAETPRTGSTQTEVSPRSSPAHSDTGTPSPMSFFGDS 250
Cdd:PRK07764   394 PAAAAPSAAAAAPAAAPAPaAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPAAA 473

                           90       100
                   ....*....|....*....|....*..
gi 2025761542  251 RSFQGSPRPRMPASQgwnSPQGAERRP 277
Cdd:PRK07764   474 PEPTAAPAPAPPAAP---APAAAPAAP 497
rad23 TIGR00601
UV excision repair protein Rad23; All proteins in this family for which functions are known ...
 173-245 1.52e-03

UV excision repair protein Rad23; All proteins in this family for which functions are known are components of a multiprotein complex used for targeting nucleotide excision repair to specific parts of the genome. In humans, Rad23 complexes with the XPC protein. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273167 [Multi-domain]  Cd Length: 378  Bit Score: 42.19  E-value: 1.52e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2025761542  173 SQPKNSSAGAEAFPSQPPSAEPPSanrSSPVQLPELHARSPPAETPRTGSTQTEVSPRSSPAHSDTGTPSPMS 245
Cdd:TIGR00601   75 SKPKTGTGKVAPPAATPTSAPTPT---PSPPASPASGMSAAPASAVEEKSPSEESATATAPESPSTSVPSSGS 144
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 166-327 1.56e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 42.85  E-value: 1.56e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025761542  166 RRHPSRPSQPKNSSAGAEAFPSQPPSAEPPSANRSSPVQLPELHARSPPA----------ETPRTGSTQTEVSPRSSPAH 235
Cdd:PHA03307   139 RPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSppaepppstpPAAASPRPPRRSSPISASAS 218

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025761542  236 SDTGTPSPMSFFGDSRSFQGSPRPRMPASQgwNSPQGAERRPHPFPSV-PWSRGQQSRGHGRPRESSHGFPDGwlpLTRD 314
Cdd:PHA03307   219 SPAPAPGRSAADDAGASSSDSSSSESSGCG--WGPENECPLPRPAPITlPTRIWEASGWNGPSSRPGPASSSS---SPRE 293

                          170
                   ....*....|...
gi 2025761542  315 SSPLWSLFAPNSP 327
Cdd:PHA03307   294 RSPSPSPSSPGSG 306
PHA03247 PHA03247
large tegument protein UL36; Provisional
 97-329 1.70e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.62  E-value: 1.70e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025761542   97 RPQVSRGPQSPHRPQprgrgGPLQGPASHLGREKTQETQGTQRSW--GRDPIRPGMFGYGRAPfALPLHRSrrhPSRPSQ 174
Cdd:PHA03247  2759 RPPTTAGPPAPAPPA-----APAAGPPRRLTRPAVASLSESRESLpsPWDPADPPAAVLAPAA-ALPPAAS---PAGPLP 2829

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025761542  175 PKNSSAGAEAFPSQPPSaEPPSANRSSPVQLPELHARSPPAETPRTGSTQTEVSPRSSPAHSDTGTPSPMSFFGDSRSFQ 254
Cdd:PHA03247  2830 PPTSAQPTAPPPPPGPP-PPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERP 2908

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025761542  255 GSPR-PRMPASQGWNSPQGAERRPHPFPSVPWSRGQQSRGHGRPRESSHGFPDGWL----------PLTRDSSPLWSLFA 323
Cdd:PHA03247  2909 PQPQaPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLgalvpgrvavPRFRVPQPAPSREA 2988


                   ....*.
gi 2025761542  324 PNSPVP 329
Cdd:PHA03247  2989 PASSTP 2994
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 171-290 1.75e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 42.39  E-value: 1.75e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025761542  171 RPSQPKNSSAGAEAFPSQPPSAEPPSANRSSPVQLPELHARSPPAETPRTGSTQTEVSP-RSSPAHSDTGTPSPMSffGD 249
Cdd:PRK14951   365 KPAAAAEAAAPAEKKTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPaPVAAPAAAAPAAAPAA--AP 442

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 2025761542  250 SRSFQGSPRPRMPASQGWNSPQGAERRPHPFPSVPWSRGQQ 290
Cdd:PRK14951   443 AAVALAPAPPAQAAPETVAIPVRVAPEPAVASAAPAPAAAP 483
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 91-334 2.09e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 42.08  E-value: 2.09e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025761542   91 PRGQSSRPQVSRGPQSPHRPQPRGRGGPLQGPASHLGREKTQETQGTQRSWGRDPIRP-GMFGYGRAP-----FALPLHR 164
Cdd:PHA03307   199 PAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPlPRPAPITLPtriweASGWNGP 278

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025761542  165 SRRHPSRPSQPKNSSAGAEAFPSQPPSAEPPSANRSSPVQLPElhARSPPAETPRTGSTQTEVSPRSSPAHSDTGTPSPm 244
Cdd:PHA03307   279 SSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSS--RESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSR- 355

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025761542  245 sffgDSRSFQGSPRPRMPASqgwNSPQGAERRPHPFPSVPWSRGQQSrGHGRPRESSHGFPDGWLPLT-RDSSPLWSLFA 323
Cdd:PHA03307   356 ----PPPPADPSSPRKRPRP---SRAPSSPAASAGRPTRRRARAAVA-GRARRRDATGRFPAGRPRPSpLDAGAASGAFY 427

                          250
                   ....*....|.
gi 2025761542  324 PNSPVPNCSGE 334
Cdd:PHA03307   428 ARYPLLTPSGE 438
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 90-292 2.78e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 41.60  E-value: 2.78e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025761542   90 RPRGQSSrPQVSRGPQSPHRP-QPRGRGGPLQGPASHLGREKTQETQGTQRSWGRDPIRPGMFGYGRAPFALPLHRSRRH 168
Cdd:PTZ00449   647 RPEGPKI-IKSPKPPKSPKPPfDPKFKEKFYDDYLDAAAKSKETKTTVVLDESFESILKETLPETPGTPFTTPRPLPPKL 725

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025761542  169 PSRPSQPKNSsagaeafPSQPPSAEPPSANRSSPVQLPELHARSPPAETPRTGSTQTEVspRSSPAHSDTGTPSpmsffg 248
Cdd:PTZ00449   726 PRDEEFPFEP-------IGDPDAEQPDDIEFFTPPEEERTFFHETPADTPLPDILAEEF--KEEDIHAETGEPD------ 790

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....
gi 2025761542  249 dsrsfQGSPRPRMPASQgwnspqgAERRPHPFPSVPWSRGQQSR 292
Cdd:PTZ00449   791 -----EAMKRPDSPSEH-------EDKPPGDHPSLPKKRHRLDG 822
KAR9 pfam08580
Yeast cortical protein KAR9; The KAR9 protein in Saccharomyces cerevisiae is a cytoskeletal ...
 157-316 3.13e-03

Yeast cortical protein KAR9; The KAR9 protein in Saccharomyces cerevisiae is a cytoskeletal protein required for karyogamy, correct positioning of the mitotic spindle and for orientation of cytoplasmic microtubules. KAR9 localizes at the shmoo tip in mating cells and at the tip of the growing bud in anaphase.


Pssm-ID: 430088 [Multi-domain]  Cd Length: 684  Bit Score: 41.35  E-value: 3.13e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025761542  157 PFALPLHRSRRHPSRPSQPKNSSAGAEAFPSQPPSAEPPSANRSSPVQLPELHARSPPAETPRTGSTQTEVSP---RSSP 233
Cdd:pfam08580  491 PSKIPRASPNHSGFLSTPSNTATSETPTPALRPPSRPQPPPPGNRPRWNASTNTNDLDVGHNFKPLTLTTPSPtpsRSSR 570

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025761542  234 AHSDTGTPSPMSfFGDSRSFQGSPRPRMPASQGWNSPQGAE-RRPHPFPSV----PWSRGQQSRGHGRPRESSHGFpdGW 308
Cdd:pfam08580  571 SSSTLPPVSPLS-RDKSRSPAPTCRSVSRASRRRASRKPTRiGSPNSRTSLldepPYPKLTLSKGLPRTPRNRQSY--AG 647


                   ....*...
gi 2025761542  309 LPLTRDSS 316
Cdd:pfam08580  648 TSPSRSVS 655
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 694-750 4.42e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 36.41  E-value: 4.42e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 2025761542   694 WEAGEWTSCSRSCGPGTQQRQLLCRqefgDGGSSVPPERCGHLPRpnITQPCQLRLC 750
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCC----SPPPQNGGGPCTGEDV--ETRACNEQPC 52
TSP_1 pfam00090
Thrombospondin type 1 domain;
944-992 6.68e-03

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 35.86  E-value: 6.68e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 2025761542  944 TLWSPCSRSCQGGMQTREVQClSANQTLGTRCPPRLRPSRKrsCNSQPC 992
Cdd:pfam00090    4 SPWSPCSVTCGKGIQVRQRTC-KSPFPGGEPCTGDDIETQA--CKMDKC 49
PHA03378 PHA03378
EBNA-3B; Provisional
 110-305 7.05e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 40.44  E-value: 7.05e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025761542  110 PQPRGRGGPLQGPASHLGREKTQE---TQGTQRSWGRdPIRPGMFGYGRAPFALPLHRSRRHPSRPSQ--PKNSSAGAEA 184
Cdd:PHA03378   590 PSYAQTPWPVPHPSQTPEPPTTQShipETSAPRQWPM-PLRPIPMRPLRMQPITFNVLVFPTPHQPPQveITPYKPTWTQ 668

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025761542  185 FPSQPPSAEPPSANRSSPVQLPELHARSPPAETPRTGSTQTEVSPRSSPAHSDTGTPSPMSFFGDSRSFQGSP---RPRM 261
Cdd:PHA03378   669 IGHIPYQPSPTGANTMLPIQWAPGTMQPPPRAPTPMRPPAAPPGRAQRPAAATGRARPPAAAPGRARPPAAAPgraRPPA 748

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2025761542  262 PASQGWNSPQGAERR------------PHPFPSVPWSRGQQSRGHGRPRESSHGFP 305
Cdd:PHA03378   749 AAPGRARPPAAAPGRarppaaapgaptPQPPPQAPPAPQQRPRGAPTPQPPPQAGP 804
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 750-808 9.74e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 35.26  E-value: 9.74e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 2025761542   750 CGHWkisSPWGQCSVRCGRGQRNRQVRCVGSDGDeVSSQECasgPPPPPSREACDMGPC 808
Cdd:smart00209    1 WSEW---SEWSPCSVTCGGGVQTRTRSCCSPPPQ-NGGGPC---TGEDVETRACNEQPC 52
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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