NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|149744263|ref|XP_001489886|]
View 

ankyrin repeat and SOCS box protein 11 isoform X1 [Equus caballus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
25-282 7.20e-35

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 128.53  E-value: 7.20e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149744263  25 KLLIKVFLALLTHFYIVKGNRKEAARIAEEIYGGISDCWADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHE 104
Cdd:COG0666   14 ALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHA 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149744263 105 ACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKA-QLEAHLASPIHEAVKRGHRECMEILL 183
Cdd:COG0666   94 AARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVnAQDNDGNTPLHLAAANGNLEIVKLLL 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149744263 184 ANNVNIDQEVPQLGTPLYVACTFQRVDCVKKLLELGASVDH-GQWLDTPLHAAARQSSVEVIHLLTDYGANLKCRNAQGK 262
Cdd:COG0666  174 EAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAkDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGL 253

                        250       260
                 ....*....|....*....|
gi 149744263 263 SALDLAAPKSSVEQALLLRE 282
Cdd:COG0666  254 TALLLAAAAGAALIVKLLLL 273
SOCS_ASB_9_11 cd03728
SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have ...
 282-323 1.66e-19

SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


:

Pssm-ID: 239698  Cd Length: 42  Bit Score: 80.22  E-value: 1.66e-19
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 149744263 282 EGPSALSQLCRLCVRKCLGRACHQTIHKLHLPEPLERFLLYQ 323
Cdd:cd03728    1 EGPPSLMQLCRLCIRKCFGRKQHHKIHKLHLPEPLKHFLLYR 42
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
25-282 7.20e-35

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 128.53  E-value: 7.20e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149744263  25 KLLIKVFLALLTHFYIVKGNRKEAARIAEEIYGGISDCWADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHE 104
Cdd:COG0666   14 ALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHA 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149744263 105 ACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKA-QLEAHLASPIHEAVKRGHRECMEILL 183
Cdd:COG0666   94 AARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVnAQDNDGNTPLHLAAANGNLEIVKLLL 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149744263 184 ANNVNIDQEVPQLGTPLYVACTFQRVDCVKKLLELGASVDH-GQWLDTPLHAAARQSSVEVIHLLTDYGANLKCRNAQGK 262
Cdd:COG0666  174 EAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAkDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGL 253

                        250       260
                 ....*....|....*....|
gi 149744263 263 SALDLAAPKSSVEQALLLRE 282
Cdd:COG0666  254 TALLLAAAAGAALIVKLLLL 273
SOCS_ASB_9_11 cd03728
SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have ...
 282-323 1.66e-19

SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239698  Cd Length: 42  Bit Score: 80.22  E-value: 1.66e-19
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 149744263 282 EGPSALSQLCRLCVRKCLGRACHQTIHKLHLPEPLERFLLYQ 323
Cdd:cd03728    1 EGPPSLMQLCRLCIRKCFGRKQHHKIHKLHLPEPLKHFLLYR 42
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 39-286 2.45e-17

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 82.02  E-value: 2.45e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149744263  39 YIVKG-----NRKEAARIAEEIYGGISDCWADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVA- 112
Cdd:PHA03100   4 YIVLTksriiKVKNIKYIIMEDDLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNLt 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149744263 113 ----CAKALLENGAHVNGVTVHGATPLFNA--CCSGSAACVNVLLEFGAKAQL-EAHLASPIHEAVKRGHR--ECMEILL 183
Cdd:PHA03100  84 dvkeIVKLLLEYGANVNAPDNNGITPLLYAisKKSNSYSIVEYLLDNGANVNIkNSDGENLLHLYLESNKIdlKILKLLI 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149744263 184 ANNVNIDqevpqlgtplyvACTfqRVDCvkkLLELGASVD----HGqwlDTPLHAAARQSSVEVIHLLTDYGANLKCRNA 259
Cdd:PHA03100 164 DKGVDIN------------AKN--RVNY---LLSYGVPINikdvYG---FTPLHYAVYNNNPEFVKYLLDLGANPNLVNK 223

                        250       260
                 ....*....|....*....|....*...
gi 149744263 260 QGKSALDLAAPKSSVE-QALLLREGPSA 286
Cdd:PHA03100 224 YGDTPLHIAILNNNKEiFKLLLNNGPSI 251
Ank_2 pfam12796
Ankyrin repeats (3 copies);
102-191 6.65e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 68.99  E-value: 6.65e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149744263  102 LHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFgAKAQLEAHLASPIHEAVKRGHRECMEI 181
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGRTALHYAARSGHLEIVKL 79

                          90
                  ....*....|
gi 149744263  182 LLANNVNIDQ 191
Cdd:pfam12796  80 LLEKGADINV 89
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 283-321 2.08e-10

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 55.25  E-value: 2.08e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 149744263  283 GPSALSQLCRLCVRKCLGRACHQTIHKLHLPEPLERFLL 321
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRRLGAIDKLPLPPLLKDYLL 39
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 287-323 3.66e-06

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 42.78  E-value: 3.66e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 149744263   287 LSQLCRLCVRKCLGRachqtIHKLHLPEPLERFLLYQ 323
Cdd:smart00969   3 LQHLCRLAIRRSLGG-----IDKLPLPPRLKDYLLYY 34
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
25-282 7.20e-35

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 128.53  E-value: 7.20e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149744263  25 KLLIKVFLALLTHFYIVKGNRKEAARIAEEIYGGISDCWADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHE 104
Cdd:COG0666   14 ALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHA 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149744263 105 ACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKA-QLEAHLASPIHEAVKRGHRECMEILL 183
Cdd:COG0666   94 AARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVnAQDNDGNTPLHLAAANGNLEIVKLLL 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149744263 184 ANNVNIDQEVPQLGTPLYVACTFQRVDCVKKLLELGASVDH-GQWLDTPLHAAARQSSVEVIHLLTDYGANLKCRNAQGK 262
Cdd:COG0666  174 EAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAkDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGL 253

                        250       260
                 ....*....|....*....|
gi 149744263 263 SALDLAAPKSSVEQALLLRE 282
Cdd:COG0666  254 TALLLAAAAGAALIVKLLLL 273
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
32-265 6.46e-31

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 117.75  E-value: 6.46e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149744263  32 LALLTHFYIVKGNRKEAARIAEEIYGGISDCWADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHV 111
Cdd:COG0666   54 GALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNL 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149744263 112 ACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLE-AHLASPIHEAVKRGHRECMEILLANNVNID 190
Cdd:COG0666  134 EIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARdNDGETPLHLAAENGHLEIVKLLLEAGADVN 213

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 149744263 191 QEVPQLGTPLYVACTFQRVDCVKKLLELGASVDH-GQWLDTPLHAAARQSSVEVIHLLTDYGANLKCRNAQGKSAL 265
Cdd:COG0666  214 AKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAkDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
SOCS_ASB_9_11 cd03728
SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have ...
 282-323 1.66e-19

SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239698  Cd Length: 42  Bit Score: 80.22  E-value: 1.66e-19
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 149744263 282 EGPSALSQLCRLCVRKCLGRACHQTIHKLHLPEPLERFLLYQ 323
Cdd:cd03728    1 EGPPSLMQLCRLCIRKCFGRKQHHKIHKLHLPEPLKHFLLYR 42
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 39-286 2.45e-17

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 82.02  E-value: 2.45e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149744263  39 YIVKG-----NRKEAARIAEEIYGGISDCWADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVA- 112
Cdd:PHA03100   4 YIVLTksriiKVKNIKYIIMEDDLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNLt 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149744263 113 ----CAKALLENGAHVNGVTVHGATPLFNA--CCSGSAACVNVLLEFGAKAQL-EAHLASPIHEAVKRGHR--ECMEILL 183
Cdd:PHA03100  84 dvkeIVKLLLEYGANVNAPDNNGITPLLYAisKKSNSYSIVEYLLDNGANVNIkNSDGENLLHLYLESNKIdlKILKLLI 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149744263 184 ANNVNIDqevpqlgtplyvACTfqRVDCvkkLLELGASVD----HGqwlDTPLHAAARQSSVEVIHLLTDYGANLKCRNA 259
Cdd:PHA03100 164 DKGVDIN------------AKN--RVNY---LLSYGVPINikdvYG---FTPLHYAVYNNNPEFVKYLLDLGANPNLVNK 223

                        250       260
                 ....*....|....*....|....*...
gi 149744263 260 QGKSALDLAAPKSSVE-QALLLREGPSA 286
Cdd:PHA03100 224 YGDTPLHIAILNNNKEiFKLLLNNGPSI 251
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 45-268 3.63e-16

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 78.95  E-value: 3.63e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149744263  45 RKEAARIAEEIYGGISDCWAD----RSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLEN 120
Cdd:PHA02876 154 QQDELLIAEMLLEGGADVNAKdiycITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDN 233

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149744263 121 -----------------------------GAHVNGVTVHGATPLFNACCSGS-AACVNVLLEFGAKAQLE-AHLASPIHE 169
Cdd:PHA02876 234 rsninkndlsllkairnedletslllydaGFSVNSIDDCKNTPLHHASQAPSlSRLVPKLLERGADVNAKnIKGETPLYL 313

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149744263 170 AVKRGH-RECMEILLANNVNIDQEVPQLGTPLYVACTFQRV-DCVKKLLELGASVDHGQWLD-TPLHAAARQSSVEVIHL 246
Cdd:PHA02876 314 MAKNGYdTENIRTLIMLGADVNAADRLYITPLHQASTLDRNkDIVITLLELGANVNARDYCDkTPIHYAAVRNNVVIINT 393

                        250       260
                 ....*....|....*....|..
gi 149744263 247 LTDYGANLKCRNAQGKSALDLA 268
Cdd:PHA02876 394 LLDYGADIEALSQKIGTALHFA 415
Ank_2 pfam12796
Ankyrin repeats (3 copies);
102-191 6.65e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 68.99  E-value: 6.65e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149744263  102 LHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFgAKAQLEAHLASPIHEAVKRGHRECMEI 181
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGRTALHYAARSGHLEIVKL 79

                          90
                  ....*....|
gi 149744263  182 LLANNVNIDQ 191
Cdd:pfam12796  80 LLEKGADINV 89
Ank_2 pfam12796
Ankyrin repeats (3 copies);
69-156 2.81e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 67.45  E-value: 2.81e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149744263   69 LHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENgAHVNgVTVHGATPLFNACCSGSAACVN 148
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVN-LKDNGRTALHYAARSGHLEIVK 78


                  ....*...
gi 149744263  149 VLLEFGAK 156
Cdd:pfam12796  79 LLLEKGAD 86
SOCS_ASB_like cd03716
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB ...
 282-323 4.29e-14

SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable number of repeats. SSB proteins contain a central SPRY domain and a C-terminal SOCS. Recently, it has been shown that all four SSB proteins interact with the MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), and that SSB-1, SSB-2, and SSB-4 interact with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain.


Pssm-ID: 239686  Cd Length: 42  Bit Score: 65.21  E-value: 4.29e-14
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 149744263 282 EGPSALSQLCRLCVRKCLGRACHQTIHKLHLPEPLERFLLYQ 323
Cdd:cd03716    1 STPRSLQHLCRLAIRRCLGRRRLELIKKLPLPPRLKDYLLYE 42
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 81-268 5.02e-14

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 72.30  E-value: 5.02e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149744263  81 LKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQL- 159
Cdd:PHA02874 107 IKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVk 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149744263 160 EAHLASPIHEAVKRGHRECMEILLANNVNIDQEVPQLGTPLYVACTFQRvdCVKKLLELGASVDHgQWLD--TPLHAAAR 237
Cdd:PHA02874 187 DNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNR--SAIELLINNASIND-QDIDgsTPLHHAIN 263

                        170       180       190
                 ....*....|....*....|....*....|..
gi 149744263 238 -QSSVEVIHLLTDYGANLKCRNAQGKSALDLA 268
Cdd:PHA02874 264 pPCDIDIIDILLYHKADISIKDNKGENPIDTA 295
Ank_2 pfam12796
Ankyrin repeats (3 copies);
167-258 8.22e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 65.91  E-value: 8.22e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149744263  167 IHEAVKRGHRECMEILLANNVNIDQEVPQLGTPLYVACTFQRVDCVKKLLElGASVDHGQWLDTPLHAAARQSSVEVIHL 246
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDNGRTALHYAARSGHLEIVKL 79

                          90
                  ....*....|..
gi 149744263  247 LTDYGANLKCRN 258
Cdd:pfam12796  80 LLEKGADINVKD 91
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 59-279 3.99e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 67.01  E-value: 3.99e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149744263  59 ISDCwaDRSPLHEAAAQGRLLAL-KTLIAQGVNVNLVTINRVSSLHEACLGGH-VACAKALLENGAHVNGVTVHGATPLF 136
Cdd:PHA02876 269 IDDC--KNTPLHHASQAPSLSRLvPKLLERGADVNAKNIKGETPLYLMAKNGYdTENIRTLIMLGADVNAADRLYITPLH 346

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149744263 137 NACC-SGSAACVNVLLEFGAKAQLEAHL-ASPIHEAVKRGHRECMEILLANNVNIDQEVPQLGTPLYVA-CTFQRVDCVK 213
Cdd:PHA02876 347 QASTlDRNKDIVITLLELGANVNARDYCdKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFAlCGTNPYMSVK 426

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 149744263 214 KLLELGASVD-HGQWLDTPLHAAARQS-SVEVIHLLTDYGANLKCRNAQGKSALDLAAPKSSVEQALL 279
Cdd:PHA02876 427 TLIDRGANVNsKNKDLSTPLHYACKKNcKLDVIEMLLDNGADVNAINIQNQYPLLIALEYHGIVNILL 494
SOCS cd03587
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 284-323 5.42e-12

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239641  Cd Length: 41  Bit Score: 59.41  E-value: 5.42e-12
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 149744263 284 PSALSQLCRLCVRKCLGRACHQTIHKLHLPEPLERFLLYQ 323
Cdd:cd03587    2 PRSLQHLCRLAIRRCLGKRRLDLIDKLPLPPRLKDYLLYK 41
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 101-275 1.21e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 65.01  E-value: 1.21e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149744263 101 SLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEA-HLASPIHEAVKRGHRECM 179
Cdd:PHA02875   5 ALCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYpDIESELHDAVEEGDVKAV 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149744263 180 EILLANNVNIDQEVPQLG-TPLYVACTFQRVDCVKKLLELGASVDHGQwLD--TPLHAAARQSSVEVIHLLTDYGANLKC 256
Cdd:PHA02875  85 EELLDLGKFADDVFYKDGmTPLHLATILKKLDIMKLLIARGADPDIPN-TDkfSPLHLAVMMGDIKGIELLIDHKACLDI 163

                        170
                 ....*....|....*....
gi 149744263 257 RNAQGKSALDLAAPKSSVE 275
Cdd:PHA02875 164 EDCCGCTPLIIAMAKGDIA 182
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 115-273 1.28e-11

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 64.90  E-value: 1.28e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149744263 115 KALLENGAHVNGVTVH-GATPLFNACCSGSAACVNVLLEFGAKAQ-LEAHLASPIHEAVKRGHRECMEILLANNVNIDQE 192
Cdd:PHA02878 151 KLLLSYGADINMKDRHkGNTALHYATENKDQRLTELLLSYGANVNiPDKTNNSPLHHAVKHYNKPIVHILLENGASTDAR 230

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149744263 193 VPQLGTPLYVACTF-QRVDCVKKLLELGASVDHGQWLD--TPLHAAARqsSVEVIHLLTDYGANLKCRNAQGKSALDLAA 269
Cdd:PHA02878 231 DKCGNTPLHISVGYcKDYDILKLLLEHGVDVNAKSYILglTALHSSIK--SERKLKLLLEYGADINSLNSYKLTPLSSAV 308


                 ....
gi 149744263 270 PKSS 273
Cdd:PHA02878 309 KQYL 312
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 283-321 2.08e-10

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 55.25  E-value: 2.08e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 149744263  283 GPSALSQLCRLCVRKCLGRACHQTIHKLHLPEPLERFLL 321
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRRLGAIDKLPLPPLLKDYLL 39
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 72-224 9.31e-10

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 59.88  E-value: 9.31e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149744263  72 AAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLL 151
Cdd:PLN03192 532 VASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILY 611

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 149744263 152 EFgakaqleAHLASP------IHEAVKRGHRECMEILLANNVNIDQEVPQLGTPLYVACTFQRVDCVKKLLELGASVDH 224
Cdd:PLN03192 612 HF-------ASISDPhaagdlLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDK 683
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 76-269 1.39e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 58.82  E-value: 1.39e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149744263  76 GRLLALKTLIAQGVN-VNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFG 154
Cdd:PHA02874  12 GDIEAIEKIIKNKGNcINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNG 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149744263 155 AKAQLeahLASPIHEavkrghRECMEILLANNVNIDQEVPQLGTPLYVACTFQRVDCVKKLLELGASV----DHGQWldt 230
Cdd:PHA02874  92 VDTSI---LPIPCIE------KDMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVniedDNGCY--- 159

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 149744263 231 PLHAAARQSSVEVIHLLTDYGANLKCRNAQGKSALDLAA 269
Cdd:PHA02874 160 PIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAA 198
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 54-253 2.76e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 57.69  E-value: 2.76e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149744263  54 EIYGGISdcwadrsPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVH-GA 132
Cdd:PHA02875  31 EIYDGIS-------PIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKFADDVFYKdGM 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149744263 133 TPLFNACCSGSAACVNVLLEFGAKAQL-EAHLASPIHEAVKRGHRECMEILLANNVNIDQEVPQLGTPLYVACTFQRVDC 211
Cdd:PHA02875 104 TPLHLATILKKLDIMKLLIARGADPDIpNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAI 183

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 149744263 212 VKKLLELGASVDH-GQWLD-TPLHAAARQSSVEVIHLLTDYGAN 253
Cdd:PHA02875 184 CKMLLDSGANIDYfGKNGCvAALCYAIENNKIDIVRLFIKRGAD 227
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 67-258 4.31e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 57.28  E-value: 4.31e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149744263  67 SPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVhgatPLFNaccsgsAAC 146
Cdd:PHA02874  37 TPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVDTSILPI----PCIE------KDM 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149744263 147 VNVLLEFGAKAQL-EAHLASPIHEAVKRGHRECMEILLANNVNIDQEVPQLGTPLYVACTFQRVDCVKKLLELGASVD-H 224
Cdd:PHA02874 107 IKTILDCGIDVNIkDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANvK 186

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 149744263 225 GQWLDTPLHAAARQSSVEVIHLLTDYGANL--KCRN 258
Cdd:PHA02874 187 DNNGESPLHNAAEYGDYACIKLLIDHGNHImnKCKN 222
SOCS_ASB5 cd03724
SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a ...
 284-323 1.29e-07

SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB5 has been implicated in the initiation of arteriogenesis. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239694  Cd Length: 42  Bit Score: 47.18  E-value: 1.29e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 149744263 284 PSALSQLCRLCVRKCLGRACHQTIHKLHLPEPLERFLLYQ 323
Cdd:cd03724    3 PSSLCQLCRLCIRNYIGRSRLHLIPQLQLPTLLKNFLQYR 42
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 67-190 1.62e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 52.36  E-value: 1.62e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149744263  67 SPLHEAAAQGR--LLALKTLIAQGVNVNLvtINRVsslheaclgghvacaKALLENGAHVNGVTVHGATPLFNACCSGSA 144
Cdd:PHA03100 143 NLLHLYLESNKidLKILKLLIDKGVDINA--KNRV---------------NYLLSYGVPINIKDVYGFTPLHYAVYNNNP 205

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 149744263 145 ACVNVLLEFGAKAQLEAHLA-SPIHEAVKRGHRECMEILLANNVNID 190
Cdd:PHA03100 206 EFVKYLLDLGANPNLVNKYGdTPLHIAILNNNKEIFKLLLNNGPSIK 252
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 114-183 2.53e-07

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 52.21  E-value: 2.53e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 149744263 114 AKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQ-LEAHLASPIHEAVKRGHRECMEILL 183
Cdd:PTZ00322  98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTlLDKDGKTPLELAEENGFREVVQLLS 168
PHA03095 PHA03095
ankyrin-like protein; Provisional
 71-280 3.45e-07

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 51.56  E-value: 3.45e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149744263  71 EAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAK---ALLENGAHVNGVTVHGATPLFNACCSGS-AAC 146
Cdd:PHA03095  20 LNASNVTVEEVRRLLAAGADVNFRGEYGKTPLHLYLHYSSEKVKDivrLLLEAGADVNAPERCGFTPLHLYLYNATtLDV 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149744263 147 VNVLLEFGA---------KAQLEAHLASP-IHEAVkrghrecMEILLANNVNIDQEVPQLGTPLYVACTFQRVD--CVKK 214
Cdd:PHA03095 100 IKLLIKAGAdvnakdkvgRTPLHVYLSGFnINPKV-------IRLLLRKGADVNALDLYGMTPLAVLLKSRNANveLLRL 172

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 149744263 215 LLELGASV-DHGQWLDTPLH--AAARQSSVEVIHLLTDYGANLKCRNAQGKSALDLAAPKSSVEQALLL 280
Cdd:PHA03095 173 LIDAGADVyAVDDRFRSLLHhhLQSFKPRARIVRELIRAGCDPAATDMLGNTPLHSMATGSSCKRSLVL 241
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 36-233 4.21e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 51.22  E-value: 4.21e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149744263  36 THFYIVKGNRKEAARIAEEIYGGISDCWADR---SPLHEAAAQGRLL-ALKTLIAQGVNVNLVTINRVSSLHEACLGGHV 111
Cdd:PHA02876 309 TPLYLMAKNGYDTENIRTLIMLGADVNAADRlyiTPLHQASTLDRNKdIVITLLELGANVNARDYCDKTPIHYAAVRNNV 388

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149744263 112 ACAKALLENGAHVNGVTVHGATPL-FNACCSGSAACVNVLLEFGAKAQLE-AHLASPIHEAVKRGHR-ECMEILLANNVN 188
Cdd:PHA02876 389 VIINTLLDYGADIEALSQKIGTALhFALCGTNPYMSVKTLIDRGANVNSKnKDLSTPLHYACKKNCKlDVIEMLLDNGAD 468

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 149744263 189 IDQEVPQLGTPLYVACTFQRVdcVKKLLELGASVDHGQWLDTPLH 233
Cdd:PHA02876 469 VNAINIQNQYPLLIALEYHGI--VNILLHYGAELRDSRVLHKSLN 511
Ank_4 pfam13637
Ankyrin repeats (many copies);
66-118 4.58e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 46.11  E-value: 4.58e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 149744263   66 RSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALL 118
Cdd:pfam13637   2 LTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
SOCS_SSB1_4 cd03718
SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box ...
 284-323 5.40e-07

SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF) and also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239688  Cd Length: 42  Bit Score: 45.37  E-value: 5.40e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 149744263 284 PSALSQLCRLCVRKCLGRACHQTIHKLHLPEPLERFLLYQ 323
Cdd:cd03718    3 PLPLMDLCRRRVRVALGRDRLEEIEQLPLPPSLKNYLLYQ 42
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 133-282 7.81e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 50.35  E-value: 7.81e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149744263 133 TPLFNACCSGSAACVNVLLEFGAKA-QLEAHLASPIHEAVKRGHRECMEILLANNVniDQEVpqlgtpLYVACTFQrvDC 211
Cdd:PHA02874  37 TPLIDAIRSGDAKIVELFIKHGADInHINTKIPHPLLTAIKIGAHDIIKLLIDNGV--DTSI------LPIPCIEK--DM 106

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 149744263 212 VKKLLELGASVD-HGQWLDTPLHAAARQSSVEVIHLLTDYGANLKCRNAQGKSALDLAAPKSSVEQALLLRE 282
Cdd:PHA02874 107 IKTILDCGIDVNiKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLE 178
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 95-269 9.87e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 50.06  E-value: 9.87e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149744263  95 TINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEAHLASPIHE-AVKR 173
Cdd:PHA02876 142 SIEYMKLIKERIQQDELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLEcAVDS 221

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149744263 174 GHRECMEILLANNVNIDQEvpqlGTPLYVACTFQRVDCVKKLLELGASVDH-GQWLDTPLHAAARQSSV-EVIHLLTDYG 251
Cdd:PHA02876 222 KNIDTIKAIIDNRSNINKN----DLSLLKAIRNEDLETSLLLYDAGFSVNSiDDCKNTPLHHASQAPSLsRLVPKLLERG 297

                        170
                 ....*....|....*...
gi 149744263 252 ANLKCRNAQGKSALDLAA 269
Cdd:PHA02876 298 ADVNAKNIKGETPLYLMA 315
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 165-280 1.27e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 49.60  E-value: 1.27e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149744263 165 SPIHEAVKRGHRECMEILLANNVNIDQEVPQLGTPLYVACTFQRVDCVKKLLELGASVDHGQWLD--TPLHAAARQSSVE 242
Cdd:PHA02875  37 SPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKFADDVFYKDgmTPLHLATILKKLD 116

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 149744263 243 VIHLLTDYGANLKCRNAQGKSALDLAAPKSSVEQALLL 280
Cdd:PHA02875 117 IMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELL 154
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 65-253 2.00e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 48.83  E-value: 2.00e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149744263  65 DRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSA 144
Cdd:PHA02875   2 DQVALCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149744263 145 ACVNVLLEFGAKAQ--LEAHLASPIHEAVKRGHRECMEILLANNVNIDQEVPQLGTPLYVACTFQRVDCVKKLLELGASV 222
Cdd:PHA02875  82 KAVEELLDLGKFADdvFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACL 161

                        170       180       190
                 ....*....|....*....|....*....|..
gi 149744263 223 D-HGQWLDTPLHAAARQSSVEVIHLLTDYGAN 253
Cdd:PHA02875 162 DiEDCCGCTPLIIAMAKGDIAICKMLLDSGAN 193
Ank_2 pfam12796
Ankyrin repeats (3 copies);
66-125 2.17e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 45.11  E-value: 2.17e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 149744263   66 RSPLHEAAAQGRLLALKTLIAQgVNVNLVTINRvSSLHEACLGGHVACAKALLENGAHVN 125
Cdd:pfam12796  31 RTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGR-TALHYAARSGHLEIVKLLLEKGADIN 88
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 287-323 3.66e-06

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 42.78  E-value: 3.66e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 149744263   287 LSQLCRLCVRKCLGRachqtIHKLHLPEPLERFLLYQ 323
Cdd:smart00969   3 LQHLCRLAIRRSLGG-----IDKLPLPPRLKDYLLYY 34
SOCS_ASB2 cd03721
SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a ...
 282-323 4.02e-06

SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB2 targets specific proteins to destruction by the proteasome in leukemia cells that have been induced to differentiate. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239691  Cd Length: 45  Bit Score: 43.32  E-value: 4.02e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 149744263 282 EGPSALSQLCRLCVRKCLGRACHQTIHKLHLPEPLERFLLYQ 323
Cdd:cd03721    1 EPPRPLAHLCRLKVRTLIGINRIKLIDTLPLPPRLIRYLNHQ 42
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 29-214 1.19e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 46.50  E-value: 1.19e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149744263  29 KVFLallthFYIVKGNRKEAARIAEEiYGG------ISDCWadrsPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSL 102
Cdd:PHA02874 125 KTFL-----HYAIKKGDLESIKMLFE-YGAdvniedDNGCY----PIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPL 194

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149744263 103 HEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAAcVNVLLEFGAKAQLEAHLASPIHEAVKRG-HRECMEI 181
Cdd:PHA02874 195 HNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNRSA-IELLINNASINDQDIDGSTPLHHAINPPcDIDIIDI 273

                        170       180       190
                 ....*....|....*....|....*....|...
gi 149744263 182 LLANNVNIDQEVPQLGTPLYVACTFQRVDCVKK 214
Cdd:PHA02874 274 LLYHKADISIKDNKGENPIDTAFKYINKDPVIK 306
SOCS_ASB1 cd03720
SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a ...
 284-323 1.59e-05

SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239690  Cd Length: 42  Bit Score: 41.25  E-value: 1.59e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 149744263 284 PSALSQLCRLCVRKCLGRACHQTIHKLHLPEPLERFLLYQ 323
Cdd:cd03720    3 PRSLLSLCRIAVRRALGKQRLSLICSLPLPDPIKKFLLHE 42
SOCS_SSB1 cd03744
SOCS (suppressors of cytokine signaling) box of SSB1 (SPRY domain-containing SOCS box proteins) ...
 284-323 2.66e-05

SOCS (suppressors of cytokine signaling) box of SSB1 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), both the absence and the presence of HGF and enhances the HGF-MET-induced mitogen-activated protein kinases Erk-transcription factor Elk-1-serum response elements (SRE) pathway. SSB1, like SSB2 and SSB4, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239713  Cd Length: 42  Bit Score: 40.73  E-value: 2.66e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 149744263 284 PSALSQLCRLCVRKCLGRACHQTIHKLHLPEPLERFLLYQ 323
Cdd:cd03744    3 PLPLMDLCRRSVRLALGRERLSEIHTLPLPASLKNYLLYQ 42
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 102-283 2.86e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 45.64  E-value: 2.86e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149744263 102 LHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNAC-----------------CSGS--------------------- 143
Cdd:PHA02878  41 LHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICkepnklgmkemirsinkCSVFytlvaikdafnnrnveifkii 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149744263 144 --------------------------AACVNVLLEFGAKAQL--EAHLASPIHEAVKRGHRECMEILLANNVNIDqeVPQ 195
Cdd:PHA02878 121 ltnrykniqtidlvyidkkskddiieAEITKLLLSYGADINMkdRHKGNTALHYATENKDQRLTELLLSYGANVN--IPD 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149744263 196 LG--TPLYVACTFQRVDCVKKLLELGASVDH-GQWLDTPLH-AAARQSSVEVIHLLTDYGAnlkCRNAQ----GKSALDL 267
Cdd:PHA02878 199 KTnnSPLHHAVKHYNKPIVHILLENGASTDArDKCGNTPLHiSVGYCKDYDILKLLLEHGV---DVNAKsyilGLTALHS 275

                        250
                 ....*....|....*.
gi 149744263 268 AApKSSVEQALLLREG 283
Cdd:PHA02878 276 SI-KSERKLKLLLEYG 290
SOCS_ASB4_ASB18 cd03723
SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members ...
 284-321 3.14e-05

SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239693  Cd Length: 48  Bit Score: 40.89  E-value: 3.14e-05
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 149744263 284 PSALSQLCRLCVRKCLGRACHQTIHKLHLPEPLERFLL 321
Cdd:cd03723    3 PRSLQHLCRCAIRKLLGSRCHKLVPQLSLPTSLKNYLL 40
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 120-280 3.48e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 45.63  E-value: 3.48e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149744263 120 NGAHVNGVTvhgATPLFNACCSGSAACVNVLLEFGAKAQL-EAHLASPIHEAVKRGHRECMEILLANNVNIDQEVPQLGT 198
Cdd:PLN03192 517 GGEHDDPNM---ASNLLTVASTGNAALLEELLKAKLDPDIgDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNT 593

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149744263 199 PLYVACTFQRVDCVKKLLELGASVDHGQWLDTpLHAAARQSSVEVIHLLTDYGANLKCRNAQGKSALDLAAPKSSVEQAL 278
Cdd:PLN03192 594 ALWNAISAKHHKIFRILYHFASISDPHAAGDL-LCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVR 672


                 ..
gi 149744263 279 LL 280
Cdd:PLN03192 673 LL 674
SOCS_ASB13 cd03729
SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a ...
 284-322 5.55e-05

SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239699  Cd Length: 42  Bit Score: 39.77  E-value: 5.55e-05
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 149744263 284 PSALSQLCRLCVRKCLGRACHQTIHKLHLPEPLERFLLY 322
Cdd:cd03729    3 PLSLQQLCRINLRKALGTRALEKIAKLNIPNRIIDYLSY 41
Ank_4 pfam13637
Ankyrin repeats (many copies);
98-151 6.56e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.95  E-value: 6.56e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 149744263   98 RVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLL 151
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 69-157 8.43e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 44.12  E-value: 8.43e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149744263  69 LHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVN 148
Cdd:PTZ00322  86 LCQLAASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQ 165

                         90
                 ....*....|....*.
gi 149744263 149 VLL-------EFGAKA 157
Cdd:PTZ00322 166 LLSrhsqchfELGANA 181
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 68-268 1.54e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 43.33  E-value: 1.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149744263  68 PLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLengahvngvTVHGATPLFNACCSGSAACV 147
Cdd:PHA02878  40 PLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMI---------RSINKCSVFYTLVAIKDAFN 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149744263 148 N--------VLLEFGAKAQleahlASPIHEAVKRGHRECME-----ILLANNVNIDQEVPQLG-TPLYVACTFQRVDCVK 213
Cdd:PHA02878 111 NrnveifkiILTNRYKNIQ-----TIDLVYIDKKSKDDIIEaeitkLLLSYGADINMKDRHKGnTALHYATENKDQRLTE 185

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 149744263 214 KLLELGASVDHGQWLD-TPLHAAARQSSVEVIHLLTDYGANLKCRNAQGKSALDLA 268
Cdd:PHA02878 186 LLLSYGANVNIPDKTNnSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHIS 241
Ank_4 pfam13637
Ankyrin repeats (many copies);
198-247 1.59e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 38.79  E-value: 1.59e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 149744263  198 TPLYVACTFQRVDCVKKLLELGASVDH--GQWlDTPLHAAARQSSVEVIHLL 247
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAvdGNG-ETALHFAASNGNVEVLKLL 53
SOCS_SSB4 cd03743
SOCS (suppressors of cytokine signaling) box of SSB4 (SPRY domain-containing SOCS box ...
 284-323 1.65e-04

SOCS (suppressors of cytokine signaling) box of SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF). SSB4, like SSB2 and SSB1, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239712  Cd Length: 42  Bit Score: 38.40  E-value: 1.65e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 149744263 284 PSALSQLCRLCVRKCLGRACHQTIHKLHLPEPLERFLLYQ 323
Cdd:cd03743    3 PLPLMDLCRRSARQALGRHRLHHIQSLPLPQTLKNYLQYQ 42
SOCS_SSB2 cd03719
SOCS (suppressors of cytokine signaling) box of SSB2 (SPRY domain-containing SOCS box proteins) ...
 282-323 1.71e-04

SOCS (suppressors of cytokine signaling) box of SSB2 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB2 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF). SSB2, like SSB4 and SSB1, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239689  Cd Length: 42  Bit Score: 38.46  E-value: 1.71e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 149744263 282 EGPSALSQLCRLCVRKCLGRACHQTIHKLHLPEPLERFLLYQ 323
Cdd:cd03719    1 AEPHSLLHLSRLCVRHALGDTRLGQVSALPLPPAMKRYLLYQ 42
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 65-185 1.81e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 42.95  E-value: 1.81e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149744263  65 DRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEA---CLGGHVacAKALLENGAHVNG-VTVHGATPLFNACc 140
Cdd:PHA02878 201 NNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISvgyCKDYDI--LKLLLEHGVDVNAkSYILGLTALHSSI- 277

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 149744263 141 sGSAACVNVLLEFGAKAQ-LEAHLASPIHEAVK-RGHRECMEILLAN 185
Cdd:PHA02878 278 -KSERKLKLLLEYGADINsLNSYKLTPLSSAVKqYLCINIGRILISN 323
Ank_4 pfam13637
Ankyrin repeats (many copies);
230-280 4.38e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 37.64  E-value: 4.38e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 149744263  230 TPLHAAARQSSVEVIHLLTDYGANLKCRNAQGKSALDLAAPKSSVEQALLL 280
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 198-273 6.33e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 41.42  E-value: 6.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149744263 198 TPLYVACTFQRVDCVKKLLELGASVdhgQWLD----TPLHAAARQSSVEVIHLLT-------DYGANLKCRNAQGKSALD 266
Cdd:PTZ00322 117 TPLHIACANGHVQVVRVLLEFGADP---TLLDkdgkTPLELAEENGFREVVQLLSrhsqchfELGANAKPDSFTGKPPSL 193


                 ....*..
gi 149744263 267 LAAPKSS 273
Cdd:PTZ00322 194 EDSPISS 200
SOCS_ASB14 cd03730
SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a ...
 282-323 7.06e-04

SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239700  Cd Length: 57  Bit Score: 37.13  E-value: 7.06e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 149744263 282 EGPSALSQLCRLCVRKCLGR---ACHQTIHKLHLPEPLERFLLYQ 323
Cdd:cd03730    1 TNPRSLKHLCRLKIRACMGRlrlRCPVFMSFLPLPNRLKAYILYK 45
Ank_4 pfam13637
Ankyrin repeats (many copies);
165-216 9.35e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 36.87  E-value: 9.35e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 149744263  165 SPIHEAVKRGHRECMEILLANNVNIDQEVPQLGTPLYVACTFQRVDCVKKLL 216
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
SOCS smart00253
suppressors of cytokine signalling; suppressors of cytokine signalling
 278-322 1.53e-03

suppressors of cytokine signalling; suppressors of cytokine signalling


Pssm-ID: 128549  Cd Length: 43  Bit Score: 35.73  E-value: 1.53e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 149744263   278 LLLREGPSALSQLCRLCVRKCLGRachQTIHKLHLPEPLERFLLY 322
Cdd:smart00253   1 LPRPSNVPSLQHLCRFTIRRCTRT---DQIKTLPLPPKLKDYLSY 42
Ank_5 pfam13857
Ankyrin repeats (many copies);
84-135 1.72e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 36.17  E-value: 1.72e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 149744263   84 LIAQG-VNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPL 135
Cdd:pfam13857   1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
Ank_5 pfam13857
Ankyrin repeats (many copies);
226-268 2.31e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 35.79  E-value: 2.31e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 149744263  226 QWLDTPLHAAARQSSVEVIHLLTDYGANLKCRNAQGKSALDLA 268
Cdd:pfam13857  14 GEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 56-130 3.25e-03

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 39.08  E-value: 3.25e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 149744263  56 YGGISDCWADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVH 130
Cdd:PLN03192 613 FASISDPHAAGDLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKANTD 687
SOCS_ASB15 cd03731
SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a ...
 282-323 5.20e-03

SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB15 is expressed predominantly in skeletal muscle and participates in the regulation of protein turnover and muscle cell development by stimulating protein synthesis and regulating differentiation of muscle cells. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239701  Cd Length: 56  Bit Score: 34.81  E-value: 5.20e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 149744263 282 EGPSALSQLCRLCVRKCLG--RACH-QTIHKLHLPEPLERFLLYQ 323
Cdd:cd03731    1 ENPRPLKHLCRLKIRKLMGlqKLQQpSSMKKLPLPPALKRYILYK 45
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH