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Conserved domains on  [gi|45269145|ref|NP_987096|]
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kelch-like ECH-associated protein 1 [Homo sapiens]

Protein Classification

BTB_POZ_KLHL19_KEAP1 and BACK_KLHL19_KEAP1 domain-containing protein( domain architecture ID 13033114)

BTB_POZ_KLHL19_KEAP1 and BACK_KLHL19_KEAP1 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BTB_POZ_KLHL19_KEAP1 cd18248
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 56-180 1.47e-78

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


:

Pssm-ID: 349557 [Multi-domain]  Cd Length: 124  Bit Score: 244.60  E-value: 1.47e-78
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  56 LEDHTKQAFGIMNELRLSQQLCDVTLQVKYQDaPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMER 135
Cdd:cd18248   1 LEDHTKEAFQIMNELRLSQQLCDVTLKVKYQD-PKEEFMAHKVVLASSSPYFKAMFTSGLRECGMEVVPIEGVHPCVMSR 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 45269145 136 LIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLD 180
Cdd:cd18248  80 LIEFAYTASISVGEKCVLHVLPGAVMYQMDSVVKACCDFLEQQLD 124
PHA03098 super family cl33709
kelch-like protein; Provisional
 95-596 5.50e-63

kelch-like protein; Provisional


The actual alignment was detected with superfamily member PHA03098:

Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 217.33  E-value: 5.50e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145   95 AHKVVLASSSPVFKAMFTNGLREqgmEVVSIEGIHpKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDF 174
Cdd:PHA03098  25 VHKIILSSSSEYFKKMFKNNFKE---NEINLNIDY-DSFNEVIKYIYTGKINITSNNVKDILSIANYLIIDFLINLCINY 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  175 LVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVK 254
Cdd:PHA03098 101 IIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKILSDDKLNVSSEDVVLEIIIKWLT 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  255 YDCEQRRFYVQALLRAVRCHSLTPNFL-QMQLQKCEILQSDSRCKDYLVKIFeeLTLHKPTQVMPCRAPKVGRLIYTAGG 333
Cdd:PHA03098 181 SKKNNKYKDICLILKVLRITFLSEEGIkKLKRWKLRIKKKKIVFNKRCIKII--YSKKYNLNKILPRSSTFGSIIYIHIT 258

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  334 YFRQSLSYLEAYNPSDgTWLRLADlqVPRSGLAGCVV-GGLLYAVGGRNNSPDGNTDSSAldcYNPMTNQWSPCAPMSVP 412
Cdd:PHA03098 259 MSIFTYNYITNYSPLS-EINTIID--IHYVYCFGSVVlNNVIYFIGGMNKNNLSVNSVVS---YDTKTKSWNKVPELIYP 332

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  413 RNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGG-FDGTNRLNSAECYY 491
Cdd:PHA03098 333 RKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGGiSKNDELLKTVECFS 412

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  492 PERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGY---DGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYV 568
Cdd:PHA03098 413 LNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGIsyiDNIKVYNIVESYNPVTNKWTELSSLNFPRINASLCIFNNKIYV 492

                        490       500
                 ....*....|....*....|....*...
gi 45269145  569 LGGYDGHTFLDSVECYDPDTDTWSEVTR 596
Cdd:PHA03098 493 VGGDKYEYYINEIEVYDDKTNTWTLFCK 520
 
Name Accession Description Interval E-value
BTB_POZ_KLHL19_KEAP1 cd18248
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 56-180 1.47e-78

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349557 [Multi-domain]  Cd Length: 124  Bit Score: 244.60  E-value: 1.47e-78
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  56 LEDHTKQAFGIMNELRLSQQLCDVTLQVKYQDaPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMER 135
Cdd:cd18248   1 LEDHTKEAFQIMNELRLSQQLCDVTLKVKYQD-PKEEFMAHKVVLASSSPYFKAMFTSGLRECGMEVVPIEGVHPCVMSR 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 45269145 136 LIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLD 180
Cdd:cd18248  80 LIEFAYTASISVGEKCVLHVLPGAVMYQMDSVVKACCDFLEQQLD 124
PHA03098 PHA03098
kelch-like protein; Provisional
 95-596 5.50e-63

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 217.33  E-value: 5.50e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145   95 AHKVVLASSSPVFKAMFTNGLREqgmEVVSIEGIHpKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDF 174
Cdd:PHA03098  25 VHKIILSSSSEYFKKMFKNNFKE---NEINLNIDY-DSFNEVIKYIYTGKINITSNNVKDILSIANYLIIDFLINLCINY 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  175 LVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVK 254
Cdd:PHA03098 101 IIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKILSDDKLNVSSEDVVLEIIIKWLT 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  255 YDCEQRRFYVQALLRAVRCHSLTPNFL-QMQLQKCEILQSDSRCKDYLVKIFeeLTLHKPTQVMPCRAPKVGRLIYTAGG 333
Cdd:PHA03098 181 SKKNNKYKDICLILKVLRITFLSEEGIkKLKRWKLRIKKKKIVFNKRCIKII--YSKKYNLNKILPRSSTFGSIIYIHIT 258

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  334 YFRQSLSYLEAYNPSDgTWLRLADlqVPRSGLAGCVV-GGLLYAVGGRNNSPDGNTDSSAldcYNPMTNQWSPCAPMSVP 412
Cdd:PHA03098 259 MSIFTYNYITNYSPLS-EINTIID--IHYVYCFGSVVlNNVIYFIGGMNKNNLSVNSVVS---YDTKTKSWNKVPELIYP 332

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  413 RNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGG-FDGTNRLNSAECYY 491
Cdd:PHA03098 333 RKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGGiSKNDELLKTVECFS 412

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  492 PERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGY---DGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYV 568
Cdd:PHA03098 413 LNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGIsyiDNIKVYNIVESYNPVTNKWTELSSLNFPRINASLCIFNNKIYV 492

                        490       500
                 ....*....|....*....|....*...
gi 45269145  569 LGGYDGHTFLDSVECYDPDTDTWSEVTR 596
Cdd:PHA03098 493 VGGDKYEYYINEIEVYDDKTNTWTLFCK 520
BACK_KLHL19_KEAP1 cd18458
BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); ...
 178-268 2.96e-62

BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also termed cytosolic inhibitor of Nrf2 (INrf2), or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression.


Pssm-ID: 350533 [Multi-domain]  Cd Length: 91  Bit Score: 200.60  E-value: 2.96e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145 178 QLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDC 257
Cdd:cd18458   1 QLDPSNCIGIANFAEQHGCTELHKKAREYIYMHFSEVSQSEEFFNLSPCQLVALISRDELNVRCESEVYNAVIRWVKYDE 80

                        90
                ....*....|.
gi 45269145 258 EQRRFYVQALL 268
Cdd:cd18458  81 ENRRQYLEALL 91
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
350-609 1.03e-58

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 198.07  E-value: 1.03e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145 350 GTWLRLADLQVPRSGLAGCVVGGLLYAVGGRnnspDGNTDSSALDCYNPMTNQWSPCAPMS-VPRNRIGVGVIDGHIYAV 428
Cdd:COG3055   1 ATWSSLPDLPTPRSEAAAALLDGKVYVAGGL----SGGSASNSFEVYDPATNTWSELAPLPgPPRHHAAAVAQDGKLYVF 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145 429 GGSHGCIHH----NSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMN 504
Cdd:COG3055  77 GGFTGANPSstplNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLP 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145 505 TIRSG-AGVCVLHNCIYAAGGYDGQDQLNsverydveteTWTFVAPMKHRRSALGITVHQGRIYVLGGYDGhtFLDSVEC 583
Cdd:COG3055 157 TPRDHlAAAVLPDGKILVIGGRNGSGFSN----------TWTTLAPLPTARAGHAAAVLGGKILVFGGESG--FSDEVEA 224

                       250       260
                ....*....|....*....|....*.
gi 45269145 584 YDPDTDTWSEVTRMTSGRSGVGVAVT 609
Cdd:COG3055 225 YDPATNTWTALGELPTPRHGHAAVLT 250
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 184-286 5.34e-40

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 141.53  E-value: 5.34e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145   184 AIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCEQRRFY 263
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKH 80

                          90       100
                  ....*....|....*....|...
gi 45269145   264 VQALLRAVRCHSLTPNFLQMQLQ 286
Cdd:pfam07707  81 LPELLSAVRLPLLSPQYLLNLVE 103
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 184-282 2.98e-35

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 128.23  E-value: 2.98e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145    184 AIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCEQRRFY 263
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREH 80

                           90
                   ....*....|....*....
gi 45269145    264 VQALLRAVRCHSLTPNFLQ 282
Cdd:smart00875  81 LPELLEHVRLPLLSPDYLL 99
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 67-179 2.57e-33

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 123.14  E-value: 2.57e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145    67 MNELRLSQQLCDVTLQVKYQdapaaQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASIs 146
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDK-----EFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGKL- 74

                          90       100       110
                  ....*....|....*....|....*....|...
gi 45269145   147 MGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQL 179
Cdd:pfam00651  75 ISEENVDDLLAAADKLQIPSLVDKCEEFLIKSL 107
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 78-179 1.64e-25

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 100.84  E-value: 1.64e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145     78 DVTLQVKYQdapaaQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMN 157
Cdd:smart00225   1 DVTLVVGGK-----KFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLE 75

                           90       100
                   ....*....|....*....|..
gi 45269145    158 GAVMYQIDSVVRACSDFLVQQL 179
Cdd:smart00225  76 LADYLQIPGLVELCEEFLLKLL 97
 
Name Accession Description Interval E-value
BTB_POZ_KLHL19_KEAP1 cd18248
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 56-180 1.47e-78

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349557 [Multi-domain]  Cd Length: 124  Bit Score: 244.60  E-value: 1.47e-78
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  56 LEDHTKQAFGIMNELRLSQQLCDVTLQVKYQDaPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMER 135
Cdd:cd18248   1 LEDHTKEAFQIMNELRLSQQLCDVTLKVKYQD-PKEEFMAHKVVLASSSPYFKAMFTSGLRECGMEVVPIEGVHPCVMSR 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 45269145 136 LIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLD 180
Cdd:cd18248  80 LIEFAYTASISVGEKCVLHVLPGAVMYQMDSVVKACCDFLEQQLD 124
PHA03098 PHA03098
kelch-like protein; Provisional
 95-596 5.50e-63

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 217.33  E-value: 5.50e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145   95 AHKVVLASSSPVFKAMFTNGLREqgmEVVSIEGIHpKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDF 174
Cdd:PHA03098  25 VHKIILSSSSEYFKKMFKNNFKE---NEINLNIDY-DSFNEVIKYIYTGKINITSNNVKDILSIANYLIIDFLINLCINY 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  175 LVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVK 254
Cdd:PHA03098 101 IIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKILSDDKLNVSSEDVVLEIIIKWLT 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  255 YDCEQRRFYVQALLRAVRCHSLTPNFL-QMQLQKCEILQSDSRCKDYLVKIFeeLTLHKPTQVMPCRAPKVGRLIYTAGG 333
Cdd:PHA03098 181 SKKNNKYKDICLILKVLRITFLSEEGIkKLKRWKLRIKKKKIVFNKRCIKII--YSKKYNLNKILPRSSTFGSIIYIHIT 258

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  334 YFRQSLSYLEAYNPSDgTWLRLADlqVPRSGLAGCVV-GGLLYAVGGRNNSPDGNTDSSAldcYNPMTNQWSPCAPMSVP 412
Cdd:PHA03098 259 MSIFTYNYITNYSPLS-EINTIID--IHYVYCFGSVVlNNVIYFIGGMNKNNLSVNSVVS---YDTKTKSWNKVPELIYP 332

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  413 RNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGG-FDGTNRLNSAECYY 491
Cdd:PHA03098 333 RKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGGiSKNDELLKTVECFS 412

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  492 PERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGY---DGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYV 568
Cdd:PHA03098 413 LNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGIsyiDNIKVYNIVESYNPVTNKWTELSSLNFPRINASLCIFNNKIYV 492

                        490       500
                 ....*....|....*....|....*...
gi 45269145  569 LGGYDGHTFLDSVECYDPDTDTWSEVTR 596
Cdd:PHA03098 493 VGGDKYEYYINEIEVYDDKTNTWTLFCK 520
BACK_KLHL19_KEAP1 cd18458
BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); ...
 178-268 2.96e-62

BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also termed cytosolic inhibitor of Nrf2 (INrf2), or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression.


Pssm-ID: 350533 [Multi-domain]  Cd Length: 91  Bit Score: 200.60  E-value: 2.96e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145 178 QLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDC 257
Cdd:cd18458   1 QLDPSNCIGIANFAEQHGCTELHKKAREYIYMHFSEVSQSEEFFNLSPCQLVALISRDELNVRCESEVYNAVIRWVKYDE 80

                        90
                ....*....|.
gi 45269145 258 EQRRFYVQALL 268
Cdd:cd18458  81 ENRRQYLEALL 91
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
350-609 1.03e-58

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 198.07  E-value: 1.03e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145 350 GTWLRLADLQVPRSGLAGCVVGGLLYAVGGRnnspDGNTDSSALDCYNPMTNQWSPCAPMS-VPRNRIGVGVIDGHIYAV 428
Cdd:COG3055   1 ATWSSLPDLPTPRSEAAAALLDGKVYVAGGL----SGGSASNSFEVYDPATNTWSELAPLPgPPRHHAAAVAQDGKLYVF 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145 429 GGSHGCIHH----NSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMN 504
Cdd:COG3055  77 GGFTGANPSstplNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLP 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145 505 TIRSG-AGVCVLHNCIYAAGGYDGQDQLNsverydveteTWTFVAPMKHRRSALGITVHQGRIYVLGGYDGhtFLDSVEC 583
Cdd:COG3055 157 TPRDHlAAAVLPDGKILVIGGRNGSGFSN----------TWTTLAPLPTARAGHAAAVLGGKILVFGGESG--FSDEVEA 224

                       250       260
                ....*....|....*....|....*.
gi 45269145 584 YDPDTDTWSEVTRMTSGRSGVGVAVT 609
Cdd:COG3055 225 YDPATNTWTALGELPTPRHGHAAVLT 250
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
328-585 3.99e-49

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 172.65  E-value: 3.99e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145 328 IYTAGGYFRQS-LSYLEAYNPSDGTWLRLADLQVPRSGLAGCVV-GGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSP 405
Cdd:COG3055  25 VYVAGGLSGGSaSNSFEVYDPATNTWSELAPLPGPPRHHAAAVAqDGKLYVFGGFTGANPSSTPLNDVYVYDPATNTWTK 104

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145 406 CAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVL-NRLLYAVGGFDGTNRL 484
Cdd:COG3055 105 LAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDHLAAAVLpDGKILVIGGRNGSGFS 184

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145 485 NSaecyyperneWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGqdQLNSVERYDVETETWTFVAPMKHRRSALGITVHQG 564
Cdd:COG3055 185 NT----------WTTLAPLPTARAGHAAAVLGGKILVFGGESG--FSDEVEAYDPATNTWTALGELPTPRHGHAAVLTDG 252

                       250       260
                ....*....|....*....|....*
gi 45269145 565 RIYVLGGYD----GHTFLDSVECYD 585
Cdd:COG3055 253 KVYVIGGETkpgvRTPLVTSAEVYD 277
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 184-286 5.34e-40

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 141.53  E-value: 5.34e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145   184 AIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCEQRRFY 263
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKH 80

                          90       100
                  ....*....|....*....|...
gi 45269145   264 VQALLRAVRCHSLTPNFLQMQLQ 286
Cdd:pfam07707  81 LPELLSAVRLPLLSPQYLLNLVE 103
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 184-282 2.98e-35

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 128.23  E-value: 2.98e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145    184 AIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCEQRRFY 263
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREH 80

                           90
                   ....*....|....*....
gi 45269145    264 VQALLRAVRCHSLTPNFLQ 282
Cdd:smart00875  81 LPELLEHVRLPLLSPDYLL 99
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 67-179 2.57e-33

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 123.14  E-value: 2.57e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145    67 MNELRLSQQLCDVTLQVKYQdapaaQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASIs 146
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDK-----EFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGKL- 74

                          90       100       110
                  ....*....|....*....|....*....|...
gi 45269145   147 MGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQL 179
Cdd:pfam00651  75 ISEENVDDLLAAADKLQIPSLVDKCEEFLIKSL 107
BACK_KLHL2_like cd18445
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This ...
 179-292 2.83e-33

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This subfamily includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. Both KLHL2 and KLHL3 function as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins.


Pssm-ID: 350520 [Multi-domain]  Cd Length: 114  Bit Score: 123.11  E-value: 2.83e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145 179 LDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCE 258
Cdd:cd18445   1 LHPSNCLGIRAFADLHSCTDLLKYAQTYTEQHFSEVVKGEEFLLLSKEQVCELISSDDLTVPSEEKVFEAVMSWVNHDPE 80

                        90       100       110
                ....*....|....*....|....*....|....
gi 45269145 259 QRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQ 292
Cdd:cd18445  81 NRKEHLAELLEHVRLPLLSPEYLVQRVEEEELIK 114
BTB_POZ_KLHL12_C3IP1_DKIR cd18242
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 57-183 7.60e-33

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349551 [Multi-domain]  Cd Length: 124  Bit Score: 122.55  E-value: 7.60e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  57 EDHTKQAFGIMNELRLSQQLCDVTLQVKYQDapaaqFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERL 136
Cdd:cd18242   2 NSHAKSILNTMNSLRKSNTLCDVTLRVEGKE-----FPAHRIVLAACSDYFCAMFTSEMSEKGKSEVELQGLTASTMEIL 76

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 45269145 137 IEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSN 183
Cdd:cd18242  77 LDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSN 123
BACK_KLHL18 cd18457
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as ...
 179-281 1.66e-32

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A.


Pssm-ID: 350532 [Multi-domain]  Cd Length: 107  Bit Score: 120.88  E-value: 1.66e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145 179 LDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCE 258
Cdd:cd18457   1 LHPNNCLGIRQFAETMMCSSLVDAANKYIQQHFIEVSKSEEFLALSKEEVLEILSRDELNVKSEEQVFEAALAWVKYDRE 80

                        90       100
                ....*....|....*....|...
gi 45269145 259 QRRFYVQALLRAVRCHSLTPNFL 281
Cdd:cd18457  81 NREEYLPELLSKVRLPLLRPQFL 103
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 63-186 7.82e-32

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 119.32  E-value: 7.82e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  63 AFGIMNELRLSQQLCDVTLQVKYQdapaaQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYT 142
Cdd:cd18238   2 SFKVLHQFYENGELCDVTLKVGEK-----SIHCHRLVLACVSPYFRAMFTSEMAESKQDSITIKDIDEEAVELLVDFAYT 76

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 45269145 143 ASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIG 186
Cdd:cd18238  77 GKLTLTVDNVQSLLYAASLLQVEEVAKACCEFMKDHLHPSNCLG 120
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 67-186 1.40e-31

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 119.05  E-value: 1.40e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  67 MNELRLSQQLCDVTLQVKyqdapAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASIS 146
Cdd:cd18256  11 LNKLRGQHEFCDVQLQVG-----MELFSVHRLVLAASSPYFAALFAGGMSESSKDVVQIHGVEPDIFHILLDFIYTGVVE 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 45269145 147 MGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIG 186
Cdd:cd18256  86 VTVSNVQELLVAADMLQLTEVVEICCEFLKGQLHPSNCIG 125
BTB_POZ_KLHL18 cd18247
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 58-178 8.74e-31

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349556 [Multi-domain]  Cd Length: 116  Bit Score: 116.23  E-value: 8.74e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  58 DHTKQAFGIMNELRLSQQLCDVTLQVKYQdapaaQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLI 137
Cdd:cd18247   1 DLPSSGFPVMEEIRRQGKLCDVTLKVGDQ-----KFSAHRIVLAATIPYFHAMFTHDMVESKQDEITMQGIEPSALEALI 75

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 45269145 138 EFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQ 178
Cdd:cd18247  76 NFAYSGRIAIDTSNVQSLLVGASFLQLQSVKDACCEFLKER 116
BTB_POZ_KLHL7 cd18237
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 64-186 1.50e-30

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349546 [Multi-domain]  Cd Length: 126  Bit Score: 116.05  E-value: 1.50e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  64 FGIMNELRLSQQLCDVTLQVKyqdapAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTA 143
Cdd:cd18237   9 MGVMNNMRKQKTLCDVILIVE-----GREIKAHRVVLAAASHFFHLMFTSNMTESKSSEVELKDAEPDIIELLVEFAYTA 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 45269145 144 SISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIG 186
Cdd:cd18237  84 RISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQLDASNCLG 126
BTB_POZ_KLHL2-like cd18235
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 57-181 8.72e-30

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349544 [Multi-domain]  Cd Length: 121  Bit Score: 113.68  E-value: 8.72e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  57 EDHTKQAFGIMNELRLSQQLCDVTLQvkyqdAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERL 136
Cdd:cd18235   2 PQHTQKAFDVMNELRKQNLLCDVILV-----ADGVEIPAHRVVLASCSPYFHAMFTGDLSESRANRVTLQDVDGKALLLL 76

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 45269145 137 IEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDP 181
Cdd:cd18235  77 IDYVYTAEIQVTEENVQVLLPAANLLQLTDVRDACCDFLQSQLHP 121
BACK_KLHL1_like cd18444
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; ...
 178-281 9.65e-29

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This subfamily contains Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. Members of this subfamily contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels.


Pssm-ID: 350519 [Multi-domain]  Cd Length: 106  Bit Score: 110.11  E-value: 9.65e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145 178 QLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDC 257
Cdd:cd18444   1 QLHPSNCLGIRSFADAQGCTDLLKVAHNYTMEHFMEVIQNQEFLLLPAEEVAKLLASDDLNVPSEETIFHALLLWVKHDL 80

                        90       100
                ....*....|....*....|....
gi 45269145 258 EQRRFYVQALLRAVRCHSLTPNFL 281
Cdd:cd18444  81 PERKKHLAKLLALIRLPLLTPQFL 104
BTB_POZ_KLHL26 cd18255
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 67-183 9.99e-28

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349564 [Multi-domain]  Cd Length: 121  Bit Score: 107.87  E-value: 9.99e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  67 MNELRLSQQLCDVTLQVKYQdapaaQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASIS 146
Cdd:cd18255   9 LNALRAKGQLLDVTLIADGQ-----RFQAHKVVLASCSDYFRAMFTGGMRESSQDEIELKGVSAKGLKHILDFAYTSELT 83

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 45269145 147 MGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSN 183
Cdd:cd18255  84 LDLDCIQDVLGAAVHLQMLPVVELCEEFLKSAMSVEN 120
BTB_POZ_KLHL10 cd18240
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 61-183 1.30e-27

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349549 [Multi-domain]  Cd Length: 120  Bit Score: 107.41  E-value: 1.30e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  61 KQAFGIMNELRLSQQLCDVTLQVKYQdapaaQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFA 140
Cdd:cd18240   2 AMACNVFNELRLEGKLCDVVIRVNGV-----EFPAHRNILCACSPYFRALFTNGWNETEKKVYKIPGVSPEMMELIIEYA 76

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 45269145 141 YTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSN 183
Cdd:cd18240  77 YTRTVPITAENVEELLPAADQFNIMGIVKACCDFLEDQLCPEN 119
BACK_KLHL12 cd18452
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also ...
 179-281 2.64e-27

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also termed CUL3-interacting protein 1 (C3IP1), or DKIR, is a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport.


Pssm-ID: 350527 [Multi-domain]  Cd Length: 136  Bit Score: 107.10  E-value: 2.64e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145 179 LDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCE 258
Cdd:cd18452   1 LDPSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFMLLSQEEVEKLIKSDEIQVDSEEPVFEAVLNWVKHDKE 80

                        90       100
                ....*....|....*....|...
gi 45269145 259 QRRFYVQALLRAVRCHSLTPNFL 281
Cdd:cd18452  81 EREDYLPELLQYVRLPLLSPRYI 103
BTB_POZ_KLHL20_KLEIP cd18249
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 54-186 2.46e-26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349558 [Multi-domain]  Cd Length: 128  Bit Score: 104.07  E-value: 2.46e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  54 YTLEDHTKQAFGIMNELRLSQQLCDVTLQVKyqdapAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVM 133
Cdd:cd18249   1 YTSDKHPRQTLEAINLLRKHRELCDVVLVVG-----AKKIYAHRVILSACSPYFRAMFTGELAESRQTEVTIRDIDERAM 75

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 45269145 134 ERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIG 186
Cdd:cd18249  76 ELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEVCCEFLKRQLDPSNCLG 128
BTB_POZ_KLHL1-like cd18234
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 76-185 3.95e-26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349543 [Multi-domain]  Cd Length: 105  Bit Score: 102.83  E-value: 3.95e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  76 LCDVTLQVKYQDAPAaqfmaHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHV 155
Cdd:cd18234   1 LCDVILIAGDRRIPA-----HRLVLSAVSDYFAAMFTNDVREATEEEIKLKDVDPDALWTLVQYCYTGRLELKEDNVESL 75

                        90       100       110
                ....*....|....*....|....*....|
gi 45269145 156 MNGAVMYQIDSVVRACSDFLVQQLDPSNAI 185
Cdd:cd18234  76 LATACLLQLSEVVEACCGFLMKQLHPSNCL 105
BACK_KEL_like cd18508
BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch ...
 180-256 5.12e-26

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch protein (KEL) and similar proteins; KEL, also termed kelch short protein, is a component of ring canals that regulates the flow of cytoplasm between cells. It binds actin and may be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis.


Pssm-ID: 350583 [Multi-domain]  Cd Length: 77  Bit Score: 101.33  E-value: 5.12e-26
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 45269145 180 DPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYD 256
Cdd:cd18508   1 DATNCLGIHEFADAHSCVELEEAAQNYIYQHFNEVIQGEEFLSLDHESLTELISSDRLNVPSEERVYEAAVAWLKHD 77
BACK_KLHL28_BTBD5 cd18467
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also ...
 179-272 6.18e-26

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also termed BTB/POZ domain-containing protein 5 (BTBD5), belongs to the KLHL family. Its function remains unclear.


Pssm-ID: 350542 [Multi-domain]  Cd Length: 99  Bit Score: 101.95  E-value: 6.18e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145 179 LDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCE 258
Cdd:cd18467   1 LDPGNCIGISRFAETYGCHDLYLAANKYICQNFEDVCQTEEFFELTHAELDEIVSNDCLNVVTEETVFYALESWIKYDVQ 80

                        90
                ....*....|....
gi 45269145 259 QRRFYVQALLRAVR 272
Cdd:cd18467  81 ERQKYLAQLLHCVR 94
BACK_KLHL29_KBTBD9 cd18468
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also ...
 180-281 9.40e-26

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also termed Kelch repeat and BTB domain-containing protein 9 (KBTBD9), belongs to the KLHL family. Its function remains unclear. A nuclear receptor subfamily 5, group A, member 2 (NR5A2)-Kelch-like family member 29 (KLHL29) fusion transcript may participate in the origin or progression of some colon cancers.


Pssm-ID: 350543 [Multi-domain]  Cd Length: 102  Bit Score: 101.72  E-value: 9.40e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145 180 DPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCEQ 259
Cdd:cd18468   1 TPSNCLGIWALAEALQCTELHNMAKAYALQNFPDVARQEEILSISKDDIVEYLSHDSLNTKAEELVFETAIKWLKKDPKN 80

                        90       100
                ....*....|....*....|..
gi 45269145 260 RRFYVQALLRAVRCHSLTPNFL 281
Cdd:cd18468  81 RKQHIAELLAVVRLPFIHPSYL 102
BTB_POZ_KLHL21 cd18250
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 67-184 1.53e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349559 [Multi-domain]  Cd Length: 124  Bit Score: 101.77  E-value: 1.53e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  67 MNELRLSQQLCDVTLQVKYQDAPAaqfmaHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASIS 146
Cdd:cd18250  12 LSELRAERKFFDVTLCAGGREFPC-----HRTVLAAASSYFRAMFAGELRESRADRVVLHGVSAEILGLLLDFSYTGRVT 86

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 45269145 147 MGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNA 184
Cdd:cd18250  87 VTQDNVEALLRAADLFQFPSVKEACCAYLQQRLDVSNC 124
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 78-179 1.64e-25

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 100.84  E-value: 1.64e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145     78 DVTLQVKYQdapaaQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMN 157
Cdd:smart00225   1 DVTLVVGGK-----KFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLE 75

                           90       100
                   ....*....|....*....|..
gi 45269145    158 GAVMYQIDSVVRACSDFLVQQL 179
Cdd:smart00225  76 LADYLQIPGLVELCEEFLLKLL 97
BTB_POZ_KLHL28_BTBD5 cd18257
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 59-181 2.15e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349566 [Multi-domain]  Cd Length: 118  Bit Score: 101.08  E-value: 2.15e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  59 HTKQAFGIMNELRLSQQLCDVTLQVKyqdapAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIE 138
Cdd:cd18257   1 HSEQLLQGLNLLRQHHELCDVVLRVG-----DVKIHAHKVVLASCSPYFKAMFTGNLSEKENSEVEFQCIDETALQAIVE 75

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 45269145 139 FAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDP 181
Cdd:cd18257  76 YAYTGTVFISQATVESLLPAANLLQIKLVLKECCDFLESQLDP 118
BTB_POZ_KLHL4 cd18336
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 58-187 2.86e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349645 [Multi-domain]  Cd Length: 126  Bit Score: 101.28  E-value: 2.86e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  58 DHTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAaqfmaHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLI 137
Cdd:cd18336   1 NHAEQTFRKMENYLQHKQLCDVLLIAGNLKIPA-----HRLVLSAVSDYFAAMFTNDVREAKQEEIKMEGVDPDALKALV 75

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 45269145 138 EFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGI 187
Cdd:cd18336  76 HYAYTGVLELKEDTIESLLAAACLLQLSQVIDVCCNFLMKQLHPSNCLGI 125
BACK_KLHL5 cd18511
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares ...
 178-281 3.66e-25

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. It is abundantly expressed in ovary, adrenal gland, and thymus.


Pssm-ID: 350586 [Multi-domain]  Cd Length: 106  Bit Score: 100.14  E-value: 3.66e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145 178 QLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDC 257
Cdd:cd18511   1 QLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFLLLPASEIAKLLASDDMNIPNEETILNALLSWVRHDV 80

                        90       100
                ....*....|....*....|....
gi 45269145 258 EQRRFYVQALLRAVRCHSLTPNFL 281
Cdd:cd18511  81 EQRRKDLSKLLAYIRLPLLAPQFL 104
BACK_KLHL8 cd18448
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a ...
 178-272 3.75e-25

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN.


Pssm-ID: 350523 [Multi-domain]  Cd Length: 97  Bit Score: 99.69  E-value: 3.75e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145 178 QLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDC 257
Cdd:cd18448   1 HLHPSNCLGVRTFAEQHNRVDLMKMADKYACDHFNEVVECEEFVSISAQHLEKLISSSDLNVESESQVYEAVMKWVKHDP 80

                        90
                ....*....|....*
gi 45269145 258 EQRRFYVQALLRAVR 272
Cdd:cd18448  81 QHRKRHLDDLLSQVR 95
BACK_KLHL2_Mayven cd18512
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also ...
 179-303 3.94e-25

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation.


Pssm-ID: 350587 [Multi-domain]  Cd Length: 130  Bit Score: 100.88  E-value: 3.94e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145 179 LDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCE 258
Cdd:cd18512   1 LHPTNCLGIRAFADMHACTELLNQANTYAEQHFSDVVLSEEFLNLGIEQVCSLIASDKLTISSEEKVFEAVIAWVNHDKE 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 45269145 259 QRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDYLVK 303
Cdd:cd18512  81 VRQEHMAHLMEHVRLPLLSREYLVQRVEEETLVKNSSACKDYLIE 125
BTB_POZ_NS1BP cd18306
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 67-187 5.24e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349615 [Multi-domain]  Cd Length: 124  Bit Score: 100.41  E-value: 5.24e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  67 MNELRLSQQLCDVTLQVKYQDAPAaqfmaHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASIS 146
Cdd:cd18306   9 LNALRKNRQFCDVILQVGGHEIPA-----HRAVLACASPYLFELFSSDSDGESILTVKLDGLDPDAVEVLVNYAYTSRLE 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 45269145 147 MGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGI 187
Cdd:cd18306  84 VPADLVKSVYSAAKKLKMDRVKKACGDFLLEKLTPQNCIGI 124
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 76-162 1.30e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 97.62  E-value: 1.30e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  76 LCDVTLQVKYQdapaaQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHV 155
Cdd:cd18186   1 LCDVTLVVGGR-----EFPAHRAVLAARSPYFRAMFSSGMKESSSSEIELDDVSPEAFEALLDYIYTGELELSEENVEEL 75


                ....*..
gi 45269145 156 MNGAVMY 162
Cdd:cd18186  76 LAAADKL 82
BTB_POZ_KLHL3 cd18339
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 59-181 2.93e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349648 [Multi-domain]  Cd Length: 121  Bit Score: 98.25  E-value: 2.93e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  59 HTKQAFGIMNELRLSQQLCDVTLQvkyqdAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIE 138
Cdd:cd18339   4 HMKKAFKVMNELRSKQLLCDVTIV-----AEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVDGQTLSKLID 78

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 45269145 139 FAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDP 181
Cdd:cd18339  79 YIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHP 121
BTB_POZ_KLHL38 cd18268
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 67-187 5.53e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349577 [Multi-domain]  Cd Length: 129  Bit Score: 97.55  E-value: 5.53e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  67 MNELRLSQQLCDVTLQvkyqdAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASIS 146
Cdd:cd18268  14 LNSLRQERILTDVILC-----TGDKEIPCHRNVLASSSPYFRAMFCNNFRESSQAKVDLKGIDSDVLDQIVDYVYTGEIL 88

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 45269145 147 MGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGI 187
Cdd:cd18268  89 ITRDNVLPLMEAASMLQYPKLFEACSLYLQDQLTPENCLSM 129
BTB_POZ_KLHL2_Mayven cd18338
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 59-181 6.94e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349647 [Multi-domain]  Cd Length: 121  Bit Score: 97.06  E-value: 6.94e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  59 HTKQAFGIMNELRLSQQLCDVTLQvkyqdAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIE 138
Cdd:cd18338   4 HMKKAFKVMNELRSQNLLCDVTIV-----AEDVEIAAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLKMLID 78

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 45269145 139 FAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDP 181
Cdd:cd18338  79 YVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHP 121
BACK_KLHL3 cd18513
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as ...
 179-303 7.54e-24

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as a substrate adapter in Cullin3 (Cul3) E3 ubiquitin ligase complexes. It is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation.


Pssm-ID: 350588 [Multi-domain]  Cd Length: 130  Bit Score: 97.44  E-value: 7.54e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145 179 LDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCE 258
Cdd:cd18513   1 LHPTNCLGIRAFADVHTCTELLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISWIKYDKE 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 45269145 259 QRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDYLVK 303
Cdd:cd18513  81 ARLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIE 125
BTB_POZ_KLHL17_actinfilin cd18246
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 51-181 1.27e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349555 [Multi-domain]  Cd Length: 139  Bit Score: 97.02  E-value: 1.27e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  51 TFSYTLEDHTKQAFGIMNELRLSQQLCDVTLQVKyqdapAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHP 130
Cdd:cd18246  14 SISHNSKRHYHDAFVSMNRMRQRGLLCDIVLHVG-----TKEIKAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDP 88

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 45269145 131 KVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDP 181
Cdd:cd18246  89 QALEQLVQYAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDP 139
BTB_POZ_KBTBD6_7 cd18273
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 56-187 1.67e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349582 [Multi-domain]  Cd Length: 142  Bit Score: 93.74  E-value: 1.67e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  56 LEDhTKQAFGIMNELRL---SQQLCDVTLQVKYQDA---PAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIH 129
Cdd:cd18273   4 LED-AAHARALLAQLKSfydARLLTDVTIEVNGPGSgpgSGRLFPCNRNVLAAASPYFKSMFTGGLYESKQETVTIHDVD 82

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 45269145 130 PKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGI 187
Cdd:cd18273  83 SESMALIIDYCYTGRVTLSEANVQRLYAAANMLQLEYVREACASFLARRLDLSNCVGI 140
BACK_KLHL16_gigaxonin cd18455
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, ...
 181-276 2.38e-22

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, also termed Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy.


Pssm-ID: 350530 [Multi-domain]  Cd Length: 97  Bit Score: 91.61  E-value: 2.38e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145 181 PSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCEQR 260
Cdd:cd18455   2 AENCIGIRDFAERFSCPHVHYVATEYLETHFRDVSSTEEFLELSPEKLKELLSRDKLNVGNEEYIFEAVLRWVRHDPEER 81

                        90
                ....*....|....*.
gi 45269145 261 RFYVQALLRAVRCHSL 276
Cdd:cd18455  82 KVHLKDLMSSCWRSGL 97
BACK_KLHL1 cd18509
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a ...
 179-281 2.90e-22

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton in brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350584 [Multi-domain]  Cd Length: 106  Bit Score: 92.01  E-value: 2.90e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145 179 LDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCE 258
Cdd:cd18509   2 LHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQ 81

                        90       100
                ....*....|....*....|...
gi 45269145 259 QRRFYVQALLRAVRCHSLTPNFL 281
Cdd:cd18509  82 RRCSDLSMLLAYIRLPLLPPQLL 104
BACK_KLHL27_IPP cd18466
BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide ...
 179-281 6.95e-22

BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also termed Kelch-like protein 27 (KLHL27), is an actin-binding protein that may play a role in organizing the actin cytoskeleton.


Pssm-ID: 350541 [Multi-domain]  Cd Length: 103  Bit Score: 90.62  E-value: 6.95e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145 179 LDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCE 258
Cdd:cd18466   1 IDPANCIGIFQFSEQIACHDLLEFTENYIHVHFLEVQSGEEFLGLTKDQLVKILRSEELSIEDEYQVFTAAMEWILKDVG 80

                        90       100
                ....*....|....*....|...
gi 45269145 259 QRRFYVQALLRAVRCHSLTPNFL 281
Cdd:cd18466  81 KRKKHVVEVLEPVRFPLLPPQRL 103
BACK_KLHL20 cd18459
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also ...
 178-272 7.50e-22

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also termed Kelch-like ECT2-interacting protein (KLEIP), or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis.


Pssm-ID: 350534 [Multi-domain]  Cd Length: 100  Bit Score: 90.57  E-value: 7.50e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145 178 QLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDC 257
Cdd:cd18459   1 QLDPSNCLGIRAFADTHACRELLRIADKFTQHNFQEVMESEEFMLLPVNQLIDIISSDELNVRSEEQVFNAVMAWVKYNI 80

                        90
                ....*....|....*
gi 45269145 258 EQRRFYVQALLRAVR 272
Cdd:cd18459  81 QERRPHLPQVLQHVR 95
BACK_KBTBD12 cd18485
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 179-272 1.48e-21

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also termed Kelch domain-containing protein 6 (KLHDC6), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350560 [Multi-domain]  Cd Length: 100  Bit Score: 89.79  E-value: 1.48e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145 179 LDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCE 258
Cdd:cd18485   1 MDASNCLGIYYFAKQIGAEDLSDRARKYLYQHFTEVCLHEEVLEIEAHQLLTLIKSDDLNVSREESILDLVLRWVNHNRK 80

                        90
                ....*....|....
gi 45269145 259 QRRFYVQALLRAVR 272
Cdd:cd18485  81 SRVQHLVELLKQVR 94
BTB_POZ_KLHL5 cd18337
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 58-187 4.70e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It is abundantly expressed in the ovary, adrenal gland, and thymus. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349646 [Multi-domain]  Cd Length: 130  Bit Score: 89.35  E-value: 4.70e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  58 DHTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAaqfmaHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLI 137
Cdd:cd18337   5 NHAEQTFKKMENYLRHKQLCDVVLVAGDRRIPA-----HRLVLSSVSDYFAAMFTNDVREAKQEEIKMEGVEPNALWALV 79

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 45269145 138 EFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGI 187
Cdd:cd18337  80 QYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGI 129
BACK_KLHL4 cd18510
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares ...
 178-281 6.42e-21

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350585 [Multi-domain]  Cd Length: 106  Bit Score: 88.05  E-value: 6.42e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145 178 QLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDC 257
Cdd:cd18510   1 QLHPSNCLGIRSFGDAQGCTELLKVAHSYTMEHFLEVIKNQEFLLLPASEIVKLLASDDINVPDEETIFQALMMWVRHDL 80

                        90       100
                ....*....|....*....|....
gi 45269145 258 EQRRFYVQALLRAVRCHSLTPNFL 281
Cdd:cd18510  81 QNRQKDLGMLLSYIRLPLLPPQLL 104
BACK_KLHL17 cd18456
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also ...
 179-280 9.23e-21

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also termed actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GluR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in the actin-based neuronal function.


Pssm-ID: 350531 [Multi-domain]  Cd Length: 102  Bit Score: 87.36  E-value: 9.23e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145 179 LDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCE 258
Cdd:cd18456   1 LDPSNCLGIRGFADTHSCSDLLKSAHKYVLQHFVEVSKTEEFMLLPLKQVLDLISSDSLNVPSEEEVYRAVLSWVKHDVD 80

                        90       100
                ....*....|....*....|..
gi 45269145 259 QRRFYVQALLRAVRCHSLTPNF 280
Cdd:cd18456  81 GRRQHVPRLMKCVRLPLLSRDF 102
BTB_POZ_KBTBD8 cd18274
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 75-187 1.75e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349583 [Multi-domain]  Cd Length: 129  Bit Score: 87.74  E-value: 1.75e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  75 QLCDVTLQVKYqdapAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLH 154
Cdd:cd18274  21 QLTDIVVEVDH----GKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMHLVLDYAYTSRVTLTEANVQA 96

                        90       100       110
                ....*....|....*....|....*....|...
gi 45269145 155 VMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGI 187
Cdd:cd18274  97 LFTAASIFQIPSLQDQCAQFMISRLDPQNSIGV 129
BTB_POZ_KLHL6 cd18236
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 67-186 3.15e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349545 [Multi-domain]  Cd Length: 129  Bit Score: 86.83  E-value: 3.15e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  67 MNELRLSQQLCDVTLQVKYQdapaaQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASIS 146
Cdd:cd18236  15 LENLRLENSLTDVILCVDSQ-----EFSCHRVVLAAASNYFRAMFCNDLKEKYEEKIIIKGVDAETMQILLDYTYTSKVL 89

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 45269145 147 MGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIG 186
Cdd:cd18236  90 ITKQNVQRVLEAASLFQFLRMVDACASFLTEALHPENCVG 129
BTB_POZ_KLHL1 cd18335
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 59-187 8.37e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton the brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349644 [Multi-domain]  Cd Length: 126  Bit Score: 85.48  E-value: 8.37e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  59 HTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAaqfmaHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIE 138
Cdd:cd18335   2 HAEQTFRKMESYLKQQQLCDVILIAGNRKIPA-----HRLVLSAVSDYFAAMFTSDVCEAKQEEIKMEGIDPNALWDLVQ 76

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 45269145 139 FAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGI 187
Cdd:cd18335  77 FAYTGCLELKEDTIENLLAAACLLQLSQVVEVCCHFLMKLLHPSNCLGI 125
BTB_POZ_KLHL23 cd18252
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 78-186 9.63e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349561 [Multi-domain]  Cd Length: 127  Bit Score: 85.26  E-value: 9.63e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  78 DVTLQVkyqdAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMN 157
Cdd:cd18252  23 DITLQC----ASGQIFHCHKAALAACSSYFKVMFTADMKEKSNNVIKLSGIDHDILEALVNYVYTSQICITERNVQSLLE 98

                        90       100
                ....*....|....*....|....*....
gi 45269145 158 GAVMYQIDSVVRACSDFLVQQLDPSNAIG 186
Cdd:cd18252  99 AADLLQFISVKKACEQFLVRHLDIDNCLG 127
BACK_KLHL7 cd18447
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a ...
 178-272 1.49e-19

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a BTB-Kelch protein that constitutes a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 cause autosomal-dominant retinitis pigmentosa.


Pssm-ID: 350522 [Multi-domain]  Cd Length: 98  Bit Score: 83.95  E-value: 1.49e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145 178 QLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDC 257
Cdd:cd18447   1 QVDASNCLGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDE 80

                        90
                ....*....|....*
gi 45269145 258 EQRRFYVQALLRAVR 272
Cdd:cd18447  81 PNRQPYMVDILAKVR 95
BTB_POZ_KLHL25 cd18254
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 59-186 2.63e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349563 [Multi-domain]  Cd Length: 128  Bit Score: 84.29  E-value: 2.63e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  59 HTKQAFGIMNELRLSQQLCDVTLQvkyqdAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSI-EGIHPKVMERLI 137
Cdd:cd18254   5 HPDCVLTHLNTLRKQCMFTDVTLW-----AGNRSFPCHRAVLAACSRYFEAMFSNGLRESLDSTVNFhDSLHPEVLELLL 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 45269145 138 EFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIG 186
Cdd:cd18254  80 DFAYSSRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNCLG 128
BTB_POZ_KLHL24_KRIP6 cd18253
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 59-183 6.73e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349562 [Multi-domain]  Cd Length: 121  Bit Score: 82.96  E-value: 6.73e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  59 HTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAaqfmaHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIE 138
Cdd:cd18253   1 HSESILQVFNEFRDSRLFTDVIICVEGREFPC-----HRAILSACSSYFRAMFCNDHRESREMLVEINGILAEAMDCFLQ 75

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 45269145 139 FAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSN 183
Cdd:cd18253  76 YVYTGKVKITTENVQYLFETSSLFQISPLRDACAKFLEEQLDPCN 120
BACK_KBTBD8 cd18483
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 179-260 1.38e-18

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor for a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralogue TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome.


Pssm-ID: 350558 [Multi-domain]  Cd Length: 97  Bit Score: 81.06  E-value: 1.38e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145 179 LDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCE 258
Cdd:cd18483   1 LDPQNSIGVFIFADHYGHQELKERSQDYIRKKFLSVTKEQEFLHLTKDQLISILNSDDLNVEKEEHVYESIIHWFEHEQS 80


                ..
gi 45269145 259 QR 260
Cdd:cd18483  81 KR 82
BTB_POZ_KLHL30 cd18259
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 52-186 1.90e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349568 [Multi-domain]  Cd Length: 137  Bit Score: 82.19  E-value: 1.90e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  52 FSYTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAaqfmaHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPK 131
Cdd:cd18259   8 LDFCLPSHPQSILDGLQTLRSNPKLSDVTLLVGGREFPC-----HRSVLALCSHYFNAMFTGDFVESISARVEIKDVDPA 82

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 45269145 132 VMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIG 186
Cdd:cd18259  83 VMESLIDFAYTGKLTINQGNVEALIRTSNRLQFPTVRKVCSRYLQQQIDATNCLG 137
BACK_KLHL24 cd18463
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also ...
 178-255 2.47e-18

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6), or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of the BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation.


Pssm-ID: 350538 [Multi-domain]  Cd Length: 78  Bit Score: 79.75  E-value: 2.47e-18
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 45269145 178 QLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKY 255
Cdd:cd18463   1 QLDPCNCLGIQKFADTHSLKQLFEKCKKFALENFVEVSQHEEFLELCKDELIEYISNDELVVPKEEEVFEAVMRWVYH 78
BTB_POZ_KLHL40-like cd18269
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 66-187 5.17e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349578 [Multi-domain]  Cd Length: 133  Bit Score: 80.53  E-value: 5.17e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  66 IMNELRLSQQ------LCDVTLQVKYQD----APAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMER 135
Cdd:cd18269   2 QKEELRLYQQtllqdgLKDLLDENKFVDcvlkIGDKEFPCHRLVLAACSPYFRAMFLSDLEESKKKEVVLEDVDPDVMGM 81

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 45269145 136 LIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGI 187
Cdd:cd18269  82 ILKYLYTSEIDLNDQNVQDIFALASRFQIPSIFTVCVSYLQKRLSLSNCLAI 133
BTB_POZ_KLHL40_KBTBD5 cd18340
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 67-187 7.33e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349649 [Multi-domain]  Cd Length: 134  Bit Score: 80.26  E-value: 7.33e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  67 MNELRLSQQ------LCDVTLQVKYQD----APAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERL 136
Cdd:cd18340   3 VEELRLYQQtllqdgLKDLLDHNKFVDcvlkIKEKEFPCHRLVLAACSPYFRAMFLSDLEESKKREIVLEDVDPDVMGKI 82

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 45269145 137 IEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGI 187
Cdd:cd18340  83 LHYIYTSEIEITEQNVQDIFAAANMFQIPSIFTVCVSFLQKRLCLSNCLAI 133
BACK_KLHL10 cd18450
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be ...
 179-256 1.06e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis.


Pssm-ID: 350525 [Multi-domain]  Cd Length: 80  Bit Score: 78.04  E-value: 1.06e-17
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 45269145 179 LDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQ-EEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYD 256
Cdd:cd18450   1 LTPENCIGIRKFARYYFCPELERKAYRYILRNFEEVAKDsEEFLELSCEELEDIIEDDELNVKEEEVVFEAIVKWIDHD 79
BTB_POZ_KLHL37_ENC1 cd18267
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 67-187 1.56e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349576 [Multi-domain]  Cd Length: 147  Bit Score: 79.65  E-value: 1.56e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  67 MNELRLSQQLCDVTLQvkyqdAPAAQFMAHKVVLASSSPVFKAMFTNGLRE-QGMEVVSIEGIHPKVMERLIEFAYTASI 145
Cdd:cd18267  31 LNLLRQQRLFTDVLLH-----AGNRSFPCHRAVLAACSRYFEAMFSGGLKEsQDSEVNFHDSIHPEVLELLLDYAYSSRV 105

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 45269145 146 SMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGI 187
Cdd:cd18267 106 IINEENAESLLEAGDMLEFQDIRDACAEFLEKNLHPTNCLGM 147
BTB_POZ_KLHL34 cd18264
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 70-189 2.05e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349573 [Multi-domain]  Cd Length: 136  Bit Score: 79.07  E-value: 2.05e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  70 LRLSQQLCDVTLQVKyqdapAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGE 149
Cdd:cd18264  22 LRAEGFLCDVVLEAE-----GNEFPAHRSLLACSSDYFRALFKDYTQESKARVIHLPVVSAAGLQRVLDFIYTSWLSLSL 96

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 45269145 150 KCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGIAN 189
Cdd:cd18264  97 DTLEDTLEAASYLQVTEAIGLCSQYLINNLAPENCCFSAN 136
BTB2_POZ_KLHL33 cd18263
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 77-181 4.22e-17

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349572 [Multi-domain]  Cd Length: 118  Bit Score: 77.54  E-value: 4.22e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  77 CDVTLQvkyqdAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVM 156
Cdd:cd18263  14 CDVQLE-----ADGSIFRVHRVILAAGSDYFRAMFTSGMKESTQSVVQLPTIPAKDLRLLISFAYSGILHLSWENLFEAT 88

                        90       100
                ....*....|....*....|....*
gi 45269145 157 NGAVMYQIDSVVRACSDFLVQQLDP 181
Cdd:cd18263  89 CTALQLQISGALALCLDFLQREISP 113
BTB_POZ_KLHL9_13 cd18239
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 54-183 5.08e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13; KLHL9 and KLHL13 (also called BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes, thereby coordinating faithful mitotic progression and completion of cytokinesis. They contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349548 [Multi-domain]  Cd Length: 128  Bit Score: 77.54  E-value: 5.08e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  54 YTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYQDApaaQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVM 133
Cdd:cd18239   1 FTSNTHSSVVLQGFDQLRGEGLLCDVTLVPGDGDE---TFPVHRAMMASASDYFKAMFTGGMKEQELMCIKLHGVSKIGL 77

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 45269145 134 ERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSN 183
Cdd:cd18239  78 KNIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVLLISGVTLEN 127
BTB_POZ_KLHL35 cd18265
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 59-186 6.01e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349574 [Multi-domain]  Cd Length: 128  Bit Score: 77.50  E-value: 6.01e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  59 HTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAaqfmaHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIE 138
Cdd:cd18265   6 HAERILQVLNAYRRSGTFTDVVLLVDGKDFPC-----HRATLSANSAYFRAMFGGHLKESRQAVVEIQKVSAAAMEVLLD 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 45269145 139 FAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIG 186
Cdd:cd18265  81 YMYGGGLRIQEDNVESVLEASDLLQVSKLREACVRFLEGQLHPCNCLG 128
BTB_POZ_ZBTB7 cd18198
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 58-175 6.83e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349507 [Multi-domain]  Cd Length: 120  Bit Score: 77.21  E-value: 6.83e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  58 DHTKQAFGIMNELRLSQQLCDVTLQVKYQdapaaQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLI 137
Cdd:cd18198   7 DHSSEILSGLNEQRTQGLLCDVVILVQGR-----EYRTHRSVLAACSQYFKKLFTSGAVVDQQNVYEIDFVSPEALTALL 81

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 45269145 138 EFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFL 175
Cdd:cd18198  82 EFAYTATLTVSTANVGDILSAARLLEIPCVSHVCAEIL 119
BACK_KLHL30 cd18469
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs ...
 177-277 9.70e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs to the KLHL family. Its function remains unclear. Differential expression of the KLHL30 gene has been observed in glioblastoma multiforme versus normal brain.


Pssm-ID: 350544 [Multi-domain]  Cd Length: 104  Bit Score: 75.95  E-value: 9.70e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145 177 QQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYD 256
Cdd:cd18469   1 QQIDATNCLGICEFGETHGCPEVAAKAWSFLLENFEAVSQEEEFLQLEKERLVACLGDDLLQVRDEQSRLEAVLRWVGHD 80

                        90       100
                ....*....|....*....|.
gi 45269145 257 CEQRRFYVQALLRAVRCHSLT 277
Cdd:cd18469  81 PQARAAHLPELLSLVHLSLLT 101
BTB_POZ_BTBD19 cd18294
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 73-175 1.98e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349603 [Multi-domain]  Cd Length: 111  Bit Score: 75.36  E-value: 1.98e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  73 SQQLCDVTLQVkyqdAPAAQ-FMAHKVVLASSSPVFKAMFTNGLREQG-MEVVSIEGIHPKVMERLIEFAYTASISMGEK 150
Cdd:cd18294  11 NPEFSDVKFLV----GPERQeIFAHKCILAARCEVFRAMFLTGPQKEStQSPLVLSDIEPEVFRAVLEFIYTNCVTLSNH 86

                        90       100
                ....*....|....*....|....*
gi 45269145 151 CVLHVMNGAVMYQIDSVVRACSDFL 175
Cdd:cd18294  87 TVIEVLAAAVEYGLDELRKLCERFI 111
PHA02790 PHA02790
Kelch-like protein; Provisional
 87-544 2.12e-16

Kelch-like protein; Provisional


Pssm-ID: 165153 [Multi-domain]  Cd Length: 480  Bit Score: 82.40  E-value: 2.12e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145   87 DAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSI---EGIHPkvMERLIEFAYTASISMGEKCVLHVMNGAVMYQ 163
Cdd:PHA02790  27 EAIGGNIIVNSTILKKLSPYFRTHLRQKYTKNKDPVTRVcldLDIHS--LTSIVIYSYTGKVYIDSHNVVNLLRASILTS 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  164 IDSVVRACSDFLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVaKQEEFFNLSHCQLVTLISRDDLNVRCES 243
Cdd:PHA02790 105 VEFIIYTCINFILRDFRKEYCVECYMMGIEYGLSNLLCHTKDFIAKHFLEL-EDDIIDNFDYLSMKLILESDELNVPDED 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  244 EVFHACINWVKydceQRRFYVQALL----RAVRCHSLTP---NFLQMQLQKCEILQSDSRCKDYLVKIFEELTLHKpTQV 316
Cdd:PHA02790 184 YVVDFVIKWYM----KRRNRLGNLLllikNVIRSNYLSPrgiNNVKWILDCTKIFHCDKQPRKSYKYPFIEYPMNM-DQI 258

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  317 MP----CRAPKVGRLIYTAGGYFRQSL-SYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNspdgntdSS 391
Cdd:PHA02790 259 IDifhmCTSTHVGEVVYLIGGWMNNEIhNNAIAVNYISNNWIPIPPMNSPRLYASGVPANNKLYVVGGLPN-------PT 331

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  392 ALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCihHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRL 471
Cdd:PHA02790 332 SVERWFHGDAAWVNMPSLLKPRCNPAVASINNVIYVIGGHSET--DTTTEYLLPNHDQWQFGPSTYYPHYKSCALVFGRR 409

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 45269145  472 LYAVGgfdgtnrlNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETW 544
Cdd:PHA02790 410 LFLVG--------RNAEFYCESSNTWTLIDDPIYPRDNPELIIVDNKLLLIGGFYRGSYIDTIEVYNNRTYSW 474
BTB_POZ_ZBTB7A cd18326
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 58-175 2.49e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349635 [Multi-domain]  Cd Length: 120  Bit Score: 75.36  E-value: 2.49e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  58 DHTKQAFGIMNELRLSQQLCDVTLQVKYQdapaaQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLI 137
Cdd:cd18326   7 DHSSDILSSLNEQRTQGLLCDVVILVEGR-----EFPTHRSVLAACSQYFKKLFTSGAVVDQQNVYEIDFVSAEALTALL 81

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 45269145 138 EFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFL 175
Cdd:cd18326  82 DFAYTATLTVSTSNVGDILSAARLLEIPAVSHVCADLL 119
Kelch smart00612
Kelch domain;
471-517 3.19e-16

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 72.59  E-value: 3.19e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 45269145    471 LLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHN 517
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Kelch smart00612
Kelch domain;
565-611 3.70e-16

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 72.59  E-value: 3.70e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 45269145    565 RIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSGRSGVGVAVTME 611
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BACK_KLHL25_ENC2 cd18514
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also ...
 179-272 4.36e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1).


Pssm-ID: 350589 [Multi-domain]  Cd Length: 99  Bit Score: 74.11  E-value: 4.36e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145 179 LDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCE 258
Cdd:cd18514   1 LHPSNCLGMMLLSDAHQCRRLYELSWRMCLVHFETVRESEDFYSLSKDKLLDLISSDELEIEDEQVVFNAVLQWVKYDLE 80

                        90
                ....*....|....
gi 45269145 259 QRRFYVQALLRAVR 272
Cdd:cd18514  81 KRKDYLPELLRNVR 94
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 73-171 4.96e-16

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 73.92  E-value: 4.96e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  73 SQQLCDVTLQVKyqdapAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCV 152
Cdd:cd18314   3 DSEFSDVVLCVG-----DRKFFAHRIVLCARSPVFRSMLTGSMIESNLKEVTLEDVEPEIFETVLKYMYTGQVTLSEENV 77

                        90
                ....*....|....*....
gi 45269145 153 LHVMNGAVMYQIDSVVRAC 171
Cdd:cd18314  78 LDLLMLASKYQVPDLEKLC 96
BTB_POZ_KLHL16_gigaxonin cd18245
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 67-175 6.67e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349554 [Multi-domain]  Cd Length: 111  Bit Score: 73.91  E-value: 6.67e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  67 MNELRLSQQLCDVTLQVKYQdapaaQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSI--EGIHPKVMERLIEFAYTAS 144
Cdd:cd18245   5 LNSFREEPHLCDATLVVGGE-----EIPVQKNVLAAASPYFRAKLNYNPPKDDGSTYKIelEGISVEVMEEILDYIYTGQ 79

                        90       100       110
                ....*....|....*....|....*....|.
gi 45269145 145 ISMGEKCVLHVMNGAVMYQIDSVVRACSDFL 175
Cdd:cd18245  80 IKLSEDNIQDIVQAADLLLMTDLKDLCCEFL 110
Kelch smart00612
Kelch domain;
518-564 7.32e-16

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 71.44  E-value: 7.32e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 45269145    518 CIYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQG 564
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BTB_POZ_KBTBD2_BKLHD1 cd18270
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 59-185 1.84e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349579 [Multi-domain]  Cd Length: 133  Bit Score: 73.50  E-value: 1.84e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  59 HTKQAFGIMNELRL---SQQLCDVTLQVKyqdapAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMER 135
Cdd:cd18270   6 NTEYAVSLLEQLKFfyeQQLLTDIVLIVE-----GTEFPCHKMVLATCSSYFRAMFMSGLSESKQTHVHLRNVDAATLQI 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 45269145 136 LIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAI 185
Cdd:cd18270  81 IITYAYTGNLAINDSTVEQLYETACFLQVEDVLQRCREYLIKKINAENCV 130
BTB_POZ_KBTBD3_BKLHD3 cd18271
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 57-187 3.56e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349580 [Multi-domain]  Cd Length: 130  Bit Score: 72.56  E-value: 3.56e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  57 EDHTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAaqfmaHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERL 136
Cdd:cd18271   5 ECHGQQILSVLQNFREQNAFFDFNIIVKDETIPC-----HRCVLAACSDFFRAMFEVNMKERDDGSVTISNLSPKAVKAF 79

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 45269145 137 IEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGI 187
Cdd:cd18271  80 LDYAYTGKAEITDDNVEMFFQMSSFLQVSLLSKACSDFLIKSIDLTNCLQL 130
BTB_POZ_ZBTB7C_ZBTB36 cd18328
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 58-175 3.91e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349637 [Multi-domain]  Cd Length: 120  Bit Score: 71.84  E-value: 3.91e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  58 DHTKQAFGIMNELRLSQQLCDVTLQVKYQdapaaQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLI 137
Cdd:cd18328   7 NHSSEVLCSLNEQRHDGLLCDVVLIVQDQ-----EYRTHRSVLAACSKYFKKLFTAGTLADQPYVYEIDFVTPEALSAIL 81

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 45269145 138 EFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFL 175
Cdd:cd18328  82 EFAYTSTLTITTSNVKHILNAAQMLEIQCIINVCLEIM 119
BACK_KLHL38 cd18476
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs ...
 179-278 4.19e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs to the KLHL family. Its function remains unclear. The klhl38 gene has recently been identified as a possible diapause (a temporary arrest of development during early ontogeny) gene, as it is significantly up-regulated during diapause. It may also be involved in chicken preadipocyte differentiation.


Pssm-ID: 350551 [Multi-domain]  Cd Length: 99  Bit Score: 71.31  E-value: 4.19e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145 179 LDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLnVRCESEVFHACINWVKYDCE 258
Cdd:cd18476   1 LTPSNCLSMIRLSEILNCETLKKKAKDMALQCFPDVAASEDLKELCASELLDYLGDDEL-CGEEEQVFETLMVWIRHDPK 79

                        90       100
                ....*....|....*....|
gi 45269145 259 QRRFYVQALLRAVRCHSLTP 278
Cdd:cd18476  80 ARKGYIHDLFKKVRLQYVHP 99
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 507-551 1.32e-14

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 68.02  E-value: 1.32e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 45269145   507 RSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMK 551
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
BACK_KBTBD2 cd18479
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 179-272 1.67e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulating the insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation.


Pssm-ID: 350554 [Multi-domain]  Cd Length: 96  Bit Score: 69.31  E-value: 1.67e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145 179 LDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCE 258
Cdd:cd18479   1 INAENCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYHQEAFMQLSHDLLIDILSSDNLNVEKEETVREAAMLWLEYNTE 80

                        90
                ....*....|....
gi 45269145 259 QRRFYVQALLRAVR 272
Cdd:cd18479  81 SRSQYLSSVLSQIR 94
BTB_POZ_ZBTB24_ZNF450 cd18212
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 59-174 1.72e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349521 [Multi-domain]  Cd Length: 118  Bit Score: 70.21  E-value: 1.72e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  59 HTKQAFGIMNELRLSQQLCDVTLQVKyqdapAAQFMAHKVVLASSSPVFKAMFTNGlREQGMEVVSIEGIHPKVMERLIE 138
Cdd:cd18212   6 HKDTVLTNFEEQRKKDFLCDITLIVE-----NVQFRAHKALLAASSEYFSMMFADE-GEVGQSIYMLEGMVAETFGALLE 79

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 45269145 139 FAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDF 174
Cdd:cd18212  80 FIYTGCLQVGEKSLEQILATAQFLKVNDLVKAYSDY 115
BACK_KLHL23 cd18462
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is ...
 179-272 1.96e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is involved in tumorigenesis and resistance to anticancer drug treatment. It also associates with cone-rod dystrophy.


Pssm-ID: 350537 [Multi-domain]  Cd Length: 102  Bit Score: 69.38  E-value: 1.96e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145 179 LDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCE 258
Cdd:cd18462   1 LDIDNCLGMHSFAEFHVCPELEKESRRIILSRFEEVWQQEEFLELSKEKLLYILSRENLNVWKEEVLIEAVVKWVAHDVE 80

                        90
                ....*....|....
gi 45269145 259 QRRFYVQALLRAVR 272
Cdd:cd18462  81 KRIECAYDLLSSIK 94
BTB_POZ_KLHL32 cd18261
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 57-183 2.04e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349570 [Multi-domain]  Cd Length: 133  Bit Score: 70.38  E-value: 2.04e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  57 EDHTKQAFGIMNELRLSQQLCDVTLQVKYQdapaaQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERL 136
Cdd:cd18261   9 KSHKDAVLAALNQQRNDGILCDITLVAEEQ-----KFHAHKAVLAACSDYFRAMFSLCMVESEADEVNLHGVTSLGLKQA 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 45269145 137 IEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSN 183
Cdd:cd18261  84 LDFAYTGQILLEPGVIQDVLAAGSHLQLLELLSLCSHYLIQELNSFN 130
BTB_POZ_KBTBD12 cd18276
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 67-187 2.20e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349585 [Multi-domain]  Cd Length: 127  Bit Score: 70.22  E-value: 2.20e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  67 MNELRLSQQLCDVTLQvkyqdAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASIS 146
Cdd:cd18276  12 LNRMKELAELTDVVLV-----AEGEKFPCHRLVLAAFSPYFKAMFTCGLMECSQREVVLHDITAESVSIILNYMYSSDLH 86

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 45269145 147 MGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGI 187
Cdd:cd18276  87 LTNSNVQGVATAAFFLQMEDIFSVCQKYMMDHMDASNCLGI 127
Kelch smart00612
Kelch domain;
424-469 2.43e-14

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 67.20  E-value: 2.43e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 45269145    424 HIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLN 469
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVIN 46
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 553-598 2.67e-14

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 67.25  E-value: 2.67e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 45269145   553 RRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMT 598
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
BACK cd14733
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 180-234 3.00e-14

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


Pssm-ID: 350515 [Multi-domain]  Cd Length: 55  Bit Score: 67.30  E-value: 3.00e-14
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 45269145 180 DPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISR 234
Cdd:cd14733   1 DPENCLGILELADLYNLEELKEKALKFILENFEEVSKSEEFLELSVELLLELLSS 55
BTB_POZ_ZBTB44 cd18228
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 59-175 3.20e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349537 [Multi-domain]  Cd Length: 126  Bit Score: 69.50  E-value: 3.20e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  59 HTKQAFGIMNELRLSQQLCDVTLQVkyQDApaaQFMAHKVVLASSSPVFKAMFTNGLREQ-------GMEVVSIEGIHPK 131
Cdd:cd18228   2 HSQELLGKLNSLRNEGHFCDVTIRV--QDK---IFRAHKVVLAACSDFFRSKLVGQASPRlvlvspaGKCVLDLHHVTVT 76

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 45269145 132 VMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFL 175
Cdd:cd18228  77 GFAPLLEYAYTSTLSINTENIIDVLAAASYMQMFNVANTCSEFM 120
BTB_POZ_ZBTB7B_ZBTB15 cd18327
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 58-175 5.23e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349636 [Multi-domain]  Cd Length: 127  Bit Score: 69.10  E-value: 5.23e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  58 DHTKQAFGIMNELRLSQQLCDVTLQVKyqdapAAQFMAHKVVLASSSPVFKAMFTNGLREQGM-------EVVSIEGIHP 130
Cdd:cd18327   7 EHSSELLSCLNEQRRAGLLCDLTIKTR-----GLEYRTHRAVLAACSLYFRKLFTGGGGGSGDlgagggqDVCELDFVGP 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 45269145 131 KVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFL 175
Cdd:cd18327  82 EALGALLEFAYTATLTISSSNMREVLRAARLLEIPCVADACADIL 126
BTB_POZ_BPM_plant cd18280
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 73-145 8.01e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349589 [Multi-domain]  Cd Length: 121  Bit Score: 68.12  E-value: 8.01e-14
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 45269145  73 SQQLCDVTLQVKYQdapaaQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASI 145
Cdd:cd18280  11 SEEGADVTFNVDGE-----KFRAHKLVLAARSPVFRSMLFGPMREENEGEIVIEDVEPPVFKALLHFIYKDEL 78
BTB_POZ_KLHL36 cd18266
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 54-183 1.22e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349575 [Multi-domain]  Cd Length: 135  Bit Score: 68.38  E-value: 1.22e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  54 YTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAaqfmaHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVM 133
Cdd:cd18266   3 YRWADHSNLVLQGLNEQRQRGLFCDVVLVADEQRVPA-----HRNLLAVCSDYFNSMFTIGMREAHQKEVELVGASYIGL 77

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 45269145 134 ERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSN 183
Cdd:cd18266  78 KAVIDFLYSSELPLDGGNIDYVLETAHLLQIWKVVDFCCEYLENEVSEEN 127
BTB_POZ_ABTB2-like cd18297
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 76-183 1.26e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349606 [Multi-domain]  Cd Length: 117  Bit Score: 67.68  E-value: 1.26e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  76 LCDVTLQVKyqdapAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASIS---MGEKCV 152
Cdd:cd18297  12 MSDVTFLVE-----GRPFYAHKIVLVTASDRFKSMLSSGSTEAQTPVIEIPDIRYDIFQLMMQYLYTGGVEsldVAQDDA 86

                        90       100       110
                ....*....|....*....|....*....|.
gi 45269145 153 LHVMNGAVMYQIDSVVRACSDFLVQQLDPSN 183
Cdd:cd18297  87 LELLRAASFFQLDGLKRHCEILLSQQIDLDN 117
BACK_KLHL40_like cd18477
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The ...
 179-277 1.46e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells.


Pssm-ID: 350552 [Multi-domain]  Cd Length: 99  Bit Score: 66.79  E-value: 1.46e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145 179 LDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCE 258
Cdd:cd18477   1 LCLGNCLAIFRLGLLLDCPRLAVSARDFICAHFTLVAKDEDFLGLSADELIAIISSDGLNVEKEEAVFEAVMKWVREAKE 80

                        90
                ....*....|....*....
gi 45269145 259 QRRFYVQALLRAVRCHSLT 277
Cdd:cd18477  81 NRQKALPTVFESIRFRLLP 99
BTB_POZ_KLHL31_KBTBD1 cd18260
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 67-185 1.65e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349569 [Multi-domain]  Cd Length: 120  Bit Score: 67.53  E-value: 1.65e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  67 MNELRLSQQLCDVTLQVKyqdapAAQFMAHKVVLASSSPVFKAMFTnglREQGMEVVSIEGIHPKVMERLIEFAYTASIS 146
Cdd:cd18260   9 LNRMRQERFLCDLTIATK-----TKSFDVHKVVMASCSEYFRNILK---KDPSLQRVELNDISPLGLATVITYAYTGKLT 80

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 45269145 147 MGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAI 185
Cdd:cd18260  81 LSLYTIGSTISAASYLQIHALVKMCCDFLMQEMNVENCM 119
BTB_POZ_KLHL22 cd18251
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 70-183 3.45e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349560 [Multi-domain]  Cd Length: 125  Bit Score: 66.77  E-value: 3.45e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  70 LRLSQQLCDVTLQVKyqdapAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGE 149
Cdd:cd18251  17 LRDSGILFDVVLVVE-----GKPIEAHRILLAASCDYFRGMFAGGLREMQQTEVLIHGVSYNAMCKILDFIYTSELELSL 91

                        90       100       110
                ....*....|....*....|....*....|....
gi 45269145 150 KCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSN 183
Cdd:cd18251  92 DNVQETLTAACQLQIPEVIGFCCDFLMSWVDNEN 125
BACK_KBTBD3 cd18480
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 179-260 4.30e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also termed BTB and kelch domain-containing protein 3 (BKLHD3), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350555 [Multi-domain]  Cd Length: 82  Bit Score: 65.04  E-value: 4.30e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145 179 LDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCE 258
Cdd:cd18480   1 LDLSNCLQLLSFAESYGSTRLLDHALEFVMQHFSLLSQSQEFLELNFEVLEKILEADELNVPDEEAVLKAVLRWTKHDLE 80


                ..
gi 45269145 259 QR 260
Cdd:cd18480  81 AR 82
BTB_POZ_ZBTB5 cd18196
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 59-181 8.43e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 5 (ZBTB5); ZBTB5 is a POZ domain Kruppel-like zinc finger (POK) family transcription repressor of cell cycle arrest gene p21 and a potential proto-oncogene stimulating cell proliferation. ZBTB5 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349505 [Multi-domain]  Cd Length: 126  Bit Score: 65.45  E-value: 8.43e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  59 HTKQAFGIMNELRLSQQLCDVTLQVKYQdapaaQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSI--EGIHPKVMERL 136
Cdd:cd18196   4 HFEQIFQQLNYQRLHGQLCDCVIVVGNR-----HFKAHRSVLAACSTHFRALFTVAEGDQTMNMIQLdsEVVTAEAFAAL 78

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 45269145 137 IEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDP 181
Cdd:cd18196  79 IDMMYTSTLMLGESNVMDVLLAASHLHLNSVVKACKHYLTTRTLP 123
BTB_POZ_ZBTB37 cd18222
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 56-175 9.43e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37); ZBTB37 may be involved in transcriptional regulation. It is differentially expressed in aryl hydrocarbon receptor (AhR)-KO mice compared with WT mice, and may potentially contribute to the aging phenotype of AhR-KO mice. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349531 [Multi-domain]  Cd Length: 123  Bit Score: 65.45  E-value: 9.43e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  56 LEDHTKQAFGIMNELRLSQQLCDVTLQVKYQdapaaQFMAHKVVLASSSPVFKAMFTngLREqgMEVVSIEGI-HPKVME 134
Cdd:cd18222   5 IPDFSNSVLSHLNQLRMQGRLCDIVVNVQGQ-----SFRAHKVVLAASSPYFRDHMS--LNE--MSTVSISVIkNPTVFE 75

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 45269145 135 RLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFL 175
Cdd:cd18222  76 QLLSFCYTGRICLQLADIISYLTAASFLQMQHIIDKCTQIL 116
BACK_KLHL25_like cd18464
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The ...
 181-272 9.44e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The family includes KLHL25 and KLHL37. KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350539 [Multi-domain]  Cd Length: 98  Bit Score: 64.44  E-value: 9.44e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145 181 PSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCEQR 260
Cdd:cd18464   2 PSNCLGMLLLSDAHQCQRLYELSWRMCLANFTTLRKTEDFLSLPKDKLLELVSSEELEVEDERLVYEAVIGWIRYDLPRR 81

                        90
                ....*....|..
gi 45269145 261 RFYVQALLRAVR 272
Cdd:cd18464  82 HEVLPELLRSVR 93
BACK_KLHL21 cd18460
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a ...
 179-272 1.09e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively.


Pssm-ID: 350535 [Multi-domain]  Cd Length: 101  Bit Score: 64.43  E-value: 1.09e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145 179 LDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCE 258
Cdd:cd18460   1 LDVSNCLEMQDFAEAFACRGLAEAAKRFILRHIVELAKGEQFERLPLKRLLEYLSDDGLCVDKEETAYQIALRWVKADPK 80

                        90
                ....*....|....
gi 45269145 259 QRRFYVQALLRAVR 272
Cdd:cd18460  81 HRQHFWPELLQHVR 94
BACK_KLHL40_KBTBD5 cd18516
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also ...
 182-273 1.11e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5, or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy.


Pssm-ID: 350591 [Multi-domain]  Cd Length: 99  Bit Score: 64.39  E-value: 1.11e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145 182 SNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCEQRR 261
Cdd:cd18516   4 SNCLAIFRLGLLLDCPRLAVAARDFICDRFQLIARDEDFLQLSPDELIAIISSDSLNVEKEEDVFEAVMKWVGKDQEERT 83

                        90
                ....*....|..
gi 45269145 262 FYVQALLRAVRC 273
Cdd:cd18516  84 KALPVLLESIRF 95
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 58-175 1.25e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 64.95  E-value: 1.25e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  58 DHTKQAFGIMNELRLSQQLCDVTLQVKYQdapaaQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLI 137
Cdd:cd18287   4 DHVHFLSEDIGALFLNEEYSDVTFVVEEK-----RFPAHRVILAARSEYFRALLYGGMRESQQSEIELKDTNAEAFKALL 78

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 45269145 138 EFAYTASISMG---EKCVLHVMNGAVMYQIDSVVRACSDFL 175
Cdd:cd18287  79 KYIYTGRLTLTdlkEDVLLDVLGLAHQYGFEELEAAISDYL 119
BACK_NS1BP_IVNS1ABP cd18502
BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); ...
 179-268 2.61e-12

BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); NS1-BP, also called NS1-binding protein, or Aryl hydrocarbon receptor-associated protein 3, or IVNS1ABP, is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control.


Pssm-ID: 350577  Cd Length: 99  Bit Score: 63.41  E-value: 2.61e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145 179 LDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQL-VTLISRDDLNVRCESEVFHACINWVKYDC 257
Cdd:cd18502   1 LTPENCIGIRSFAGRMNDSELLQKVDSYIQENIEEVAESKEFLKLPRLQIeVILESNQELESINERKLCQLVLEWVQRSI 80

                        90
                ....*....|.
gi 45269145 258 EQRRFYVQALL 268
Cdd:cd18502  81 EEGGLDLDDLT 91
BTB_POZ_KLHL41_KBTBD10 cd18341
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 66-187 2.95e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349650 [Multi-domain]  Cd Length: 133  Bit Score: 64.10  E-value: 2.95e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  66 IMNELRLSQQ------LCDVTLQVKYQD----APAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMER 135
Cdd:cd18341   2 IKEELRLYQStllqdgLKELLDENKFVDctlkAGDKSLPCHRLILAACSPYFREYFLSEESEEKKKEVVLDNVDPNIMDM 81

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 45269145 136 LIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGI 187
Cdd:cd18341  82 ILKYLYSAEIDLNDGNVQDIFALASRFQIPSVFTVCVTYLQKRLSPANCLAI 133
PLN02193 PLN02193
nitrile-specifier protein
 461-594 3.30e-12

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 68.83  E-value: 3.30e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  461 IGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMN---TIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERY 537
Cdd:PLN02193 220 LGVRMVSIGSTLYVFGGRDASRQYNGFYSFDTTTNEWKLLTPVEegpTPRSFHSMAADEENVYVFGGVSATARLKTLDSY 299

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  538 DVETETWTFVA-PMKH--RRSALGITVHQGRIYVLGGYDGHTfLDSVECYDPDTDTWSEV 594
Cdd:PLN02193 300 NIVDKKWFHCStPGDSfsIRGGAGLEVVQGKVWVVYGFNGCE-VDDVHYYDPVQDKWTQV 358
BACK_KLHL41_KBTBD10 cd18517
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also ...
 179-273 3.35e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also called Kel-like protein 23, or Kelch repeat and BTB domain-containing protein 10, or Kelch-related protein 1 (Krp1), or sarcosine, is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils.


Pssm-ID: 350592 [Multi-domain]  Cd Length: 99  Bit Score: 62.87  E-value: 3.35e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145 179 LDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCE 258
Cdd:cd18517   1 LSVGNCLAIFRLGLLLDCPRLAVSARDFVSDRFEQISKEEDFLQLAPHELIAIISSDSLNVEKEELVFEAVMKWVRTDKE 80

                        90
                ....*....|....*
gi 45269145 259 QRrfyVQALLRAVRC 273
Cdd:cd18517  81 NR---VKSLGEIFDC 92
BACK_KLHL6 cd18446
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a ...
 179-281 5.09e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation.


Pssm-ID: 350521 [Multi-domain]  Cd Length: 108  Bit Score: 62.87  E-value: 5.09e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145 179 LDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCE 258
Cdd:cd18446   1 LHPENCVGILRLADAHSLESLKKQVQNYIIQNFSQVLNHEEFLELPVDILCHILKSDDLYVTEEEQVFETVMRWVRYKES 80

                        90       100
                ....*....|....*....|...
gi 45269145 259 QRRFYVQALLRAVRCHSLTPNFL 281
Cdd:cd18446  81 ERLPLLPRVLENVRLPLLDPWYF 103
BACK_KLHL37_ENC1 cd18515
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also ...
 181-272 5.66e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350590 [Multi-domain]  Cd Length: 98  Bit Score: 62.30  E-value: 5.66e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145 181 PSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCEQR 260
Cdd:cd18515   2 PTNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTICKTEDFLQLPKDMVVQLLSSEELETEDERLVYEAAINWVNYDLKKR 81

                        90
                ....*....|..
gi 45269145 261 RFYVQALLRAVR 272
Cdd:cd18515  82 HCYLSELLQTVR 93
BTB_POZ_ZBTB27_BCL6 cd18331
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 67-175 7.69e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349640 [Multi-domain]  Cd Length: 118  Bit Score: 62.57  E-value: 7.69e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  67 MNELRLSQQLCDVTLQVKYQdapaaQFMAHKVVLASSSPVFKAMFTNGLReQGMEVVSIE-GIHPKVMERLIEFAYTASI 145
Cdd:cd18331  15 LNRLRSRDILTDVVIVVSRE-----QFRAHKTVLMACSGLFYSIFTDQLK-CNLSVINLDpEINPEGFNILLDFMYTSRL 88

                        90       100       110
                ....*....|....*....|....*....|
gi 45269145 146 SMGEKCVLHVMNGAVMYQIDSVVRACSDFL 175
Cdd:cd18331  89 NLREGNIMAVMATAMYLQMEHVVDTCRKFI 118
BTB_POZ_ZBTB46 cd18230
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 59-182 7.72e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349539 [Multi-domain]  Cd Length: 125  Bit Score: 62.77  E-value: 7.72e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  59 HTKQAFGIMNELRLSQQLCDVTLQVKyqdapAAQFMAHKVVLASSSPVFKAMFTNGLR-EQGMEVVSIEGIHPKVMERLI 137
Cdd:cd18230   4 HYRHLLRELNEQRQHGILCDVCIIVE-----GKIFKAHKNVLLGSSRYFKTLYCQVQKtSDQATVTHLDIVTAQGFKAII 78

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 45269145 138 EFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPS 182
Cdd:cd18230  79 DFMYSAHLALTSKNVIEVMSAASYLQMTDIVQACHNFIKAALDIS 123
BTB_POZ_ZBTB34 cd18220
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 54-175 8.57e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34); ZBTB34 acts as a transcriptional regulator. It downregulates specificity protein (Sp) transcription factors Sp1, Sp3, and Sp4 in pancreatic cancer cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349529 [Multi-domain]  Cd Length: 120  Bit Score: 62.35  E-value: 8.57e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  54 YTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYQdapaaQFMAHKVVLASSSPVFKAMFTNGLreqgMEVVSIEGI-HPKV 132
Cdd:cd18220   3 FDVPEYSNTVLSQLNELRLQGKLCDIIVHIQGQ-----PFRAHKAVLAASSPYFRDHSALST----MSGLSISVIkNPNV 73

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 45269145 133 MERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFL 175
Cdd:cd18220  74 FEQLLSFCYTGRMSLQLKDVVSFLTAASFLQMQCVIDKCTQIL 116
BTB_POZ_ZBTB47_ZNF651 cd18231
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 67-175 1.03e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349540 [Multi-domain]  Cd Length: 115  Bit Score: 62.25  E-value: 1.03e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  67 MNELRLSQ-QLCDVTLQVKYQdapAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVvSIEGIHPKVMERLIEFAYTASI 145
Cdd:cd18231   4 LNEQRLFQpDLCDVDIVLVRQ---RSTFPAHKGVLAAYSQFFHSLFTQNKQLQRVEL-SLEALTSQGLQQILNFIYTSKL 79

                        90       100       110
                ....*....|....*....|....*....|
gi 45269145 146 SMGEKCVLHVMNGAVMYQIDSVVRACSDFL 175
Cdd:cd18231  80 LVNSCNVQDVLNAAAVLQMNDIAASCQELI 109
BTB_POZ_ZBTB28_BCL6B cd18332
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 59-175 1.20e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349641 [Multi-domain]  Cd Length: 114  Bit Score: 61.80  E-value: 1.20e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  59 HTKQAFGIMNELRLSQQLCDVTLQVKYQdapaaQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIE 138
Cdd:cd18332   2 HSSDVLLNLNELRKRDILTDVTLLVGGT-----PLRAHKAVLIACSGFFYSIFSGRVGEGVSVLTLPSGLEARGFQLLLD 76

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 45269145 139 FAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFL 175
Cdd:cd18332  77 FMYTSRLPLTPRTVPAVLAAATYLQMEHVVETCRRFI 113
BTB_POZ_BTBD1_2 cd18281
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 73-183 1.26e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349590 [Multi-domain]  Cd Length: 127  Bit Score: 62.07  E-value: 1.26e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  73 SQQLCDVTLQVKyQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEvVSIEGIHPKVMERLIEFAYTASISMGEKCV 152
Cdd:cd18281  19 NETLSDVHFIVG-KGDNEQRIPAHKFVLSIGSAVFDAMFNGGMATTSAE-IELPDVEPAAFLALLRFLYSDEVQIGPETV 96

                        90       100       110
                ....*....|....*....|....*....|.
gi 45269145 153 LHVMNGAVMYQIDSVVRACSDFLVQQLDPSN 183
Cdd:cd18281  97 MTTLYTAKKYAVPALESACVEFLKKNLSSDN 127
BTB_POZ_ZBTB23_GZF1 cd18211
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 67-179 1.28e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1); GZF1 is also called GDNF-inducible zinc finger protein 1, zinc finger and BTB domain-containing protein 23 (ZBTB23), or zinc finger protein 336 (ZNF336). It is a sequence-specific transcriptional repressor that binds the GZF1 responsive element (GRE), with the consensus sequence of 5'-TGCGCN[TG][CA]TATA-3'. It may play a role in renal branching morphogenesis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349520 [Multi-domain]  Cd Length: 128  Bit Score: 62.18  E-value: 1.28e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  67 MNELRLSQQLCDVTLQVKYQDApAAQFMAHKVVLASSSPVFKAMFTNGLREQG-MEVVSIEGIHPKVMERLIEFAYTASI 145
Cdd:cd18211  16 MHKLRLLGHLCDVTVQVEHQGS-KEEFSAHKAVLAASSKYFKEVFLNEKISDGkNTNVMLNEIYTADFASFLEFVYTAKV 94

                        90       100       110
                ....*....|....*....|....*....|....
gi 45269145 146 SMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQL 179
Cdd:cd18211  95 EVEEDRVQRMLEIAEKLKCLDLSETCFQLKKQML 128
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 459-504 1.43e-11

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 59.55  E-value: 1.43e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 45269145   459 RRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMN 504
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
BACK_KLHL33 cd18472
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs ...
 179-253 1.55e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs to the KLHL family. Its function remains unclear. KLHL33 SNPs may be associated with prostate cancer risk.


Pssm-ID: 350547 [Multi-domain]  Cd Length: 75  Bit Score: 60.09  E-value: 1.55e-11
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 45269145 179 LDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWV 253
Cdd:cd18472   1 LSPANCLELWAFADAATLPRLAAAARAFALKHFAEVAASAAFLSLPLARLLELLRSDELEVAEEEAVFEAAVRWL 75
BTB_POZ_KLHL15 cd18244
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 76-179 1.60e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349553 [Multi-domain]  Cd Length: 137  Bit Score: 62.28  E-value: 1.60e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  76 LCDVTLQVKYQdapaaQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHV 155
Cdd:cd18244  30 LLDVTLVIEDH-----QFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTATGFSHVLQFMYYGTIELSMLTVHEI 104

                        90       100
                ....*....|....*....|....
gi 45269145 156 MNGAVMYQIDSVVRACSDFLVQQL 179
Cdd:cd18244 105 LQAAMYVQLTEVVKFCCSFLLAKI 128
Kelch smart00612
Kelch domain;
373-423 1.72e-11

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 59.11  E-value: 1.72e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 45269145    373 LLYAVGGRNnspdGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDG 423
Cdd:smart00612   1 KIYVVGGFD----GGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BTB_POZ_BTBD14A_NAC2 cd18289
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 64-181 3.21e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349598 [Multi-domain]  Cd Length: 131  Bit Score: 61.20  E-value: 3.21e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  64 FGIMNELRLSQQLCDVTLQVKYQdapaaQFMAHKVVLASSSPVFKAMFtNGLREQGMEVVSieGIHPKVMERLIEFAYTA 143
Cdd:cd18289  17 LGCLNEQRLMGLYCDVSIVVKGQ-----AFKAHRAVLAASSLYFRDLF-SGNSKSAFELPA--TVPPACFQQILSFCYTG 88

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 45269145 144 SISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDP 181
Cdd:cd18289  89 KLTMAASEQLVVMYTAGFLQIQHIVERGTDLMFKVSSP 126
BTB2_POZ_ABTB1_BPOZ1 cd18296
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 78-180 3.52e-11

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349605 [Multi-domain]  Cd Length: 121  Bit Score: 60.77  E-value: 3.52e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  78 DVTLQVKyqdapAAQFMAHKVVLASSSPVFKAMFTNGLRE-----QGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCV 152
Cdd:cd18296  19 DVCFQVE-----GHRFPCHKAFFCGRSDYFKALLRDHFAEseennGSIPVVTLHDVSPEVFAIVLYYIYTDDTDLPPENA 93

                        90       100
                ....*....|....*....|....*...
gi 45269145 153 LHVMNGAVMYQIDSVVRACSDFLVQQLD 180
Cdd:cd18296  94 YDVLYVADMYLLPGLKRLCGTVLAQSLD 121
BTB_POZ_ARIA_plant cd18352
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 76-179 4.54e-11

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349661 [Multi-domain]  Cd Length: 116  Bit Score: 60.18  E-value: 4.54e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  76 LCDVTLQVKyqdapAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHV 155
Cdd:cd18352  13 LSDVTFLVE-----GRRFYAHRIALLASSDAFRAMFDGGYREKEARDIEIPNIRWEVFELMMRFIYTGSVDITNDIAKDL 87

                        90       100
                ....*....|....*....|....
gi 45269145 156 MNGAVMYQIDSVVRACSDFLVQQL 179
Cdd:cd18352  88 LRAADQYLLEGLKRLCEYTIAQDL 111
BTB_POZ_roadkill-like cd18345
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 73-184 5.92e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349654 [Multi-domain]  Cd Length: 121  Bit Score: 60.25  E-value: 5.92e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  73 SQQLCDVTLQVKYQdapaaQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCV 152
Cdd:cd18345  15 RSAFSDVTLCVGGR-----EFQAHKAILAARSPVFNAMFEHEMEERKQNRVEITDVDHEVMREMLRFIYTGKAPNLDKMA 89

                        90       100       110
                ....*....|....*....|....*....|..
gi 45269145 153 LHVMNGAVMYQIDSVVRACSDFLVQQLDPSNA 184
Cdd:cd18345  90 DDLLAAADKYALERLKVMCEEALCSNLSVENV 121
BTB_POZ_KBTBD4 cd18272
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 53-187 6.11e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349581 [Multi-domain]  Cd Length: 140  Bit Score: 60.68  E-value: 6.11e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  53 SYTLEDHT---KQAFGIMNELRLSQQLCDVTLQVKYQDapaaqFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIH 129
Cdd:cd18272   6 SYTFTDRShssRVAQSIMDLCLEDGLFADVTISVEGKE-----FQLHRLVLSAQSCFFRSMFTSNLKEARNRVIELKDVS 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 45269145 130 PKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGI 187
Cdd:cd18272  81 ESVFQLLVDYIYHGTVKLRVEELQETYEVADMYQLTALFEECSRFLARTVQVRNCLQV 138
BTB_POZ_BTBD3_6 cd18282
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 95-179 6.33e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This family includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349591 [Multi-domain]  Cd Length: 108  Bit Score: 59.72  E-value: 6.33e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  95 AHKVVLASSSPVFKAMFTNGLREQGMEVVsIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDF 174
Cdd:cd18282  25 AHKYVLATGSSVFYAMFYGGLAENKNEIE-IPDVEPAAFLNLLRYLYCDEIDLEPDTVLATLYAAKKYLVPHLARACVQF 103


                ....*
gi 45269145 175 LVQQL 179
Cdd:cd18282 104 LETSL 108
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 412-456 9.32e-11

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 57.24  E-value: 9.32e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 45269145   412 PRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPM 456
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSM 45
BTB_POZ_ZBTB27-like cd18215
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 59-174 1.13e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349524 [Multi-domain]  Cd Length: 113  Bit Score: 59.12  E-value: 1.13e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  59 HTKQAFGIMNELRLSQQLCDVTLQVKYQdapaaQFMAHKVVLASSSPVFKAMFTNGLReQGMEVVSIEG-IHPKVMERLI 137
Cdd:cd18215   2 HASDVLLNLNRLRSRDILTDVVLVVGRE-----QFRAHKTVLMACSGLFYSIFTDQLK-NNVSVINLDPeIEPEGFRILL 75

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 45269145 138 EFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDF 174
Cdd:cd18215  76 DFMYTSRLNLREGNIMAVMATAMYLQMEHVVDTCRKF 112
BTB_POZ_ZBTB17_MIZ1 cd18206
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 59-174 1.15e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349515 [Multi-domain]  Cd Length: 112  Bit Score: 59.17  E-value: 1.15e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  59 HTKQAFGIMNELRLSQQLCDVTLQVKYQDapaaqFMAHKVVLASSSPVFKAMFTNGlreqgMEVVSIEGIHPKVMERLIE 138
Cdd:cd18206   5 HSQHVLEQLNQQRQLGLLCDCTFVVDGVD-----FKAHKAVLAACSEYFRMLFVDQ-----KDVVHLDISNAAGLGQVLE 74

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 45269145 139 FAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDF 174
Cdd:cd18206  75 FMYTAKLSLSPENVDDVLAVATFLQMQDIVTACHAL 110
BACK_KLHL35 cd18474
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs ...
 179-256 1.47e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs to the KLHL family. Its function remains unclear. Hypermethylation of KLHL35 is associated with hepatocellular carcinoma and abdominal aortic aneurysm.


Pssm-ID: 350549 [Multi-domain]  Cd Length: 79  Bit Score: 57.52  E-value: 1.47e-10
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 45269145 179 LDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYD 256
Cdd:cd18474   1 IGANNCLALLAAADALHCAPLQEHCIRVLLRDFAQAARHPSFLKLELQLVLELLADDSLAVRSEEVVLEAALRWVDAD 78
PHA02713 PHA02713
hypothetical protein; Provisional
 396-569 1.59e-10

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 63.88  E-value: 1.59e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  396 YNPMTNQWSPCApmSVPRNRIGV--GVIDGHIYAVGG-SHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLL 472
Cdd:PHA02713 277 YNINTMEYSVIS--TIPNHIINYasAIVDNEIIIAGGyNFNNPSLNKVYKINIENKIHVELPPMIKNRCRFSLAVIDDTI 354

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  473 YAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGG------YDGQDQLNSVE----------- 535
Cdd:PHA02713 355 YAIGGQNGTNVERTIECYTMGDDKWKMLPDMPIALSSYGMCVLDQYIYIIGGrtehidYTSVHHMNSIDmeedthssnkv 434

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 45269145  536 -RYDVETETWTFVAPMKHRRSALGITVHQGRIYVL 569
Cdd:PHA02713 435 iRYDTVNNIWETLPNFWTGTIRPGVVSHKDDIYVV 469
BTB_POZ_SPOPL cd18343
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 69-183 2.21e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349652 [Multi-domain]  Cd Length: 123  Bit Score: 58.48  E-value: 2.21e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  69 ELRLSQQLCDVTLQVKYQDAP----AAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTAS 144
Cdd:cd18343   5 ECRLAEDLGNLWENSRFTDCSlfvgGQEFKAHKSILAARSPVFNAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTGK 84

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 45269145 145 ISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSN 183
Cdd:cd18343  85 APNLDKMADNLLAAADKYALERLKVMCEEALCNNLSVEN 123
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 361-410 2.73e-10

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 55.70  E-value: 2.73e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 45269145   361 PRSGLAGCVVGGLLYAVGGRnnspDGNTDSSALDCYNPMTNQWSPCAPMS 410
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGF----DGNQSLNSVEVYDPETNTWSKLPSMP 46
BTB_POZ_TDPOZ cd18344
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 92-184 3.22e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349653 [Multi-domain]  Cd Length: 128  Bit Score: 58.04  E-value: 3.22e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  92 QFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTasismGEKCVLH-------VMNGAVMYQI 164
Cdd:cd18344  34 EFRAHKAILAARSPVFRAMFEHEMEERLKNPIEIHDLDPQVFKEMMGFIYT-----GKAPHLHshsmacdVLAAADKYGL 108

                        90       100
                ....*....|....*....|
gi 45269145 165 DSVVRACSDFLVQQLDPSNA 184
Cdd:cd18344 109 EGLKVLCEDALCRNLSVENA 128
BTB_POZ_SPOP-like cd18279
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 67-179 4.87e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349588 [Multi-domain]  Cd Length: 120  Bit Score: 57.54  E-value: 4.87e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  67 MNELRLSQQLCDVTLQVKYQdapaaQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASIS 146
Cdd:cd18279   9 LGNLWENSRFTDCCLCVGGQ-----EFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTGKAP 83

                        90       100       110
                ....*....|....*....|....*....|...
gi 45269145 147 MGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQL 179
Cdd:cd18279  84 NLDKMADDLLAAADKYALERLKVMCEDALCSNL 116
BTB_POZ_ZBTB35_ZNF131 cd18221
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 59-170 5.78e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349530 [Multi-domain]  Cd Length: 113  Bit Score: 56.93  E-value: 5.78e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  59 HTKQAFGIMNELRLSQQLCDVTLQVKyqdapAAQFMAHKVVLASSSPVFKAMFTNGLREqgmEVVSIEGIHPKVMERLIE 138
Cdd:cd18221   1 HYKVMLDRLNEQRELDQFTDITLIVD-----GHQFKAHKAVLAACSQFFYKFFQDFTQE---PLVEIEGVSNMAFRHLIE 72

                        90       100       110
                ....*....|....*....|....*....|...
gi 45269145 139 FAYTASISM-GEKCVLHVMNGAVMYQIDSVVRA 170
Cdd:cd18221  73 FTYTAKLMVqGEEEANDVWKAAEYLQMQEAIKA 105
BTB_POZ_BTBD14B_NAC1 cd18290
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 67-177 7.62e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349599 [Multi-domain]  Cd Length: 123  Bit Score: 56.97  E-value: 7.62e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  67 MNELRLSQQLCDVTLQVKYQdapaaQFMAHKVVLASSSPVFKAMFTNGlREQGMEVVSieGIHPKVMERLIEFAYTASIS 146
Cdd:cd18290  18 LNEQRLQGLYCDVSVVVKGH-----AFKAHRAVLAASSSYFRDLFNSS-RSAVVELPA--AVQPQSFQQILSFCYTGRLS 89

                        90       100       110
                ....*....|....*....|....*....|...
gi 45269145 147 M--GEKCVLhvMNGAVMYQIDSVVRACSDFLVQ 177
Cdd:cd18290  90 MnvGDQFLL--MYTAGFLQIQEIMEKGTEFFLK 120
BTB_POZ_BAB-like cd18315
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 76-176 7.91e-10

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349624 [Multi-domain]  Cd Length: 85  Bit Score: 55.63  E-value: 7.91e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  76 LCDVTLQVKyqdapAAQFMAHKVVLASSSPVFKAMFTNgLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKcvlhv 155
Cdd:cd18315   1 LVDVTLACE-----GGSLKAHKLVLAAASPYFAALLKE-TPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQE----- 69

                        90       100
                ....*....|....*....|.
gi 45269145 156 mngavmyQIDSVVRACSDFLV 176
Cdd:cd18315  70 -------QLESLLKLAELLQI 83
BTB_POZ_ZBTB3 cd18323
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 58-171 8.48e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3); ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB3 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349632 [Multi-domain]  Cd Length: 128  Bit Score: 57.14  E-value: 8.48e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  58 DHTKQAFGIMNELRLSQQLCDVTLQVKyqdapAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLI 137
Cdd:cd18323   5 DHSRHLLQSLREQRHQGFLCDCTVLVG-----STQFLAHRAVLASCSPFFHMFYKEQLDKRDLVCINNEIVTAPAFSLLL 79

                        90       100       110
                ....*....|....*....|....*....|....
gi 45269145 138 EFAYTASISMGEKCVLHVMNGAVMYQIDSVVRAC 171
Cdd:cd18323  80 EFMYEGRLSFNDTPVEDVLAAASYLHMNDIVKVC 113
BTB_POZ_BTBD17 cd18292
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 67-174 9.18e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349601 [Multi-domain]  Cd Length: 114  Bit Score: 56.53  E-value: 9.18e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  67 MNELRLSQQLCDVTLQVKYQdapaaQFMAHKVVLASSSPVFKAMFTNG--LREQGMEVVSIEgihP----KVMERLIEFA 140
Cdd:cd18292   8 IAQLYNNEELSDIVLRVGGK-----VFHAHRLILAKSSDVFRVMLSNDwwSESKQSEIELVE---DpecaAVFEKFLRYL 79

                        90       100       110
                ....*....|....*....|....*....|....
gi 45269145 141 YTASISMGEKCVLHVMNGAVMYQIDSVVRACSDF 174
Cdd:cd18292  80 YTGQISVNLETALPLLMLADKYNVTDLKQLCVDF 113
BTB_POZ_SPOP cd18342
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 69-184 1.19e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349651 [Multi-domain]  Cd Length: 125  Bit Score: 56.65  E-value: 1.19e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  69 ELRLSQQLCDVTLQVKYQD----APAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTAS 144
Cdd:cd18342   6 ECRLADELGGLWENSRFTDcclcVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYTGK 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 45269145 145 ISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNA 184
Cdd:cd18342  86 APNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVENA 125
BACK_KBTBD6_7 cd18482
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing ...
 179-274 1.44e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing proteins, KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling.


Pssm-ID: 350557 [Multi-domain]  Cd Length: 99  Bit Score: 55.59  E-value: 1.44e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145 179 LDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGE-VAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDC 257
Cdd:cd18482   1 LDLSNCAGILKFADAFDNRELKSKALAFIARNFQQlLAKEEELCELSLAQLKEVLMLDSLDVDSERKVCSVAVQWIEANL 80

                        90
                ....*....|....*..
gi 45269145 258 EQRRFYVQALLRAVRCH 274
Cdd:cd18482  81 KERAASAAEVLKCVRWQ 97
BTB2_POZ_RhoBTB cd18300
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 74-179 1.51e-09

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349609 [Multi-domain]  Cd Length: 108  Bit Score: 55.71  E-value: 1.51e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  74 QQLCDVTLQVKYQDAPAaqfmaHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGE--KC 151
Cdd:cd18300   7 GLFSDVTFIVEDGTIPA-----HKALLVARCDVMAAMFGGNFRESSAKEVELPGVSKETFLALLEYLYTDQAPILEdgDC 81

                        90       100
                ....*....|....*....|....*...
gi 45269145 152 VlHVMNGAVMYQIDSVVRACSDFLVQQL 179
Cdd:cd18300  82 V-GLIVLANRLCLPRLVALCEQYIVKEL 108
BTB_POZ_ZBTB21_ZNF295 cd18209
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 59-145 2.08e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21); ZBTB21, also called zinc finger protein 295 (ZNF295), is a transcription repressor that acts in a selective manner on different promoters. It may be involved in the bi-directional control of gene expression in concert with another transcription factor ZFP161. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349518 [Multi-domain]  Cd Length: 112  Bit Score: 55.26  E-value: 2.08e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  59 HTKQAFGIMNELRLSQQLCDVTLQVKYQdapaaQFMAHKVVLASSSPVFKAMFTNGLREQgMEVVSIEGIHPKVMERLIE 138
Cdd:cd18209   1 HAISLLSALNEERLKGQLCDVLLIVGDQ-----KFRAHKNVLAASSEYFQSLFTEKENES-QSVFQLDFCEPDAFENVLN 74


                ....*..
gi 45269145 139 FAYTASI 145
Cdd:cd18209  75 YIYSSSL 81
BTB_POZ_ZBTB43 cd18227
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 67-175 2.13e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349536 [Multi-domain]  Cd Length: 121  Bit Score: 55.72  E-value: 2.13e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  67 MNELRLSQQLCDVTLQVKyqdapAAQFMAHKVVLASSSPVF--KAMFTNGLReqgmeVVSIEGIHPKVMERLIEFAYTAS 144
Cdd:cd18227  16 LNQQRQQGQLCDISVVVQ-----GHLFRAHKAVLAASSPYFcdQVLLKNSRR-----IVLPDVMNPRVFENILLSCYTGR 85

                        90       100       110
                ....*....|....*....|....*....|.
gi 45269145 145 ISMGEKCVLHVMNGAVMYQIDSVVRACSDFL 175
Cdd:cd18227  86 LVLPAPEIVSYLTAASFLQMWHVVDKCTELL 116
BTB_POZ_ZBTB19_PATZ1 cd18207
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 51-177 2.19e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349516 [Multi-domain]  Cd Length: 128  Bit Score: 55.74  E-value: 2.19e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  51 TFSYTLEDHTKQAFGIMNELRLSQ-QLCDVTLQVKYQDAPAaqfmaHKVVLASSSPVFKAMFTNGLrEQGMEVVSIE--G 127
Cdd:cd18207   1 SYTYQVSQHSADMLHNLNQQRKSGgRFCDVLLRVGEESFPA-----HRAVLAACSEYFESVFSAQE-GDGGTPRELEmhT 74

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 45269145 128 IHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQ 177
Cdd:cd18207  75 ISSKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIDICQEVIKQ 124
BTB_POZ_KLHL29_KBTBD9 cd18258
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 67-186 2.88e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349567 [Multi-domain]  Cd Length: 125  Bit Score: 55.36  E-value: 2.88e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  67 MNELRLSQQLCDVTLQVKyqdapAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEV---VSIEGIHPKVMERLIEFAYTA 143
Cdd:cd18258   8 LNQQRRAKEFTDLKIIVE-----GKEFEVHQNVLASCSLYFKDLIKRSSRDSGGGEkleLTMSNINADVLELLLEFVYTG 82

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 45269145 144 SISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIG 186
Cdd:cd18258  83 SLIIDSANAKTLLEAANKFQFHTFCKVCVSFLEKQLTASNCLG 125
BTB_POZ_ZBTB45 cd18229
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 67-177 3.68e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45); ZBTB45, also called zinc finger protein 499 (ZNF499), may act as a transcriptional regulator that is essential for proper glial differentiation of neural and oligodendrocyte progenitor cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349538 [Multi-domain]  Cd Length: 112  Bit Score: 54.87  E-value: 3.68e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  67 MNELRLSQQLCDVTLQVKyqdapAAQFMAHKVVLASSSPVFKAMFTNGLREqgMEVVSIegIHPKVMERLIEFAYTASIS 146
Cdd:cd18229   9 LNAQRLGGHFCDVTVRIH-----DASLRAHRCVLAAGSPFFHDKLLLGHSE--IEVPPV--VPAQTVRQLVEFMYSGSLV 79

                        90       100       110
                ....*....|....*....|....*....|.
gi 45269145 147 MGEKCVLHVMNGAVMYQIDSVVRACSDFLVQ 177
Cdd:cd18229  80 VAQSEALQILTAASILQIKTVIDECTQIISQ 110
BTB_POZ_calicin cd18307
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 77-174 4.04e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa. It contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349616 [Multi-domain]  Cd Length: 97  Bit Score: 54.04  E-value: 4.04e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  77 CDVTLQVKyqdapAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEV---VSIEGIHPKVMERLIEFAYTASISMGEKCVL 153
Cdd:cd18307   2 CDVVISVD-----NHSFAAHRNVLAAVSPFVKSLISSNDMKATDELsitIDCDYLSPETVEQLLDYFYTGKIVISEKNVE 76

                        90       100
                ....*....|....*....|.
gi 45269145 154 HVMNGAVMYQIDSVVRACSDF 174
Cdd:cd18307  77 DLLKGAKYFNIPRLKDHCVDF 97
Kelch smart00612
Kelch domain;
327-372 4.08e-09

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 52.56  E-value: 4.08e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 45269145    327 LIYTAGGY-FRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGG 372
Cdd:smart00612   1 KIYVVGGFdGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BTB1_POZ_IBtk cd18301
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 78-147 7.33e-09

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349610 [Multi-domain]  Cd Length: 99  Bit Score: 53.45  E-value: 7.33e-09
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 45269145  78 DVTLQVKYQdapaaQFMAHKVVLASSSPVFKAMFTNGLREQGM----EVVSIEGIHPKVMERLIEFAYTASISM 147
Cdd:cd18301  20 DVVFQVGGK-----TFPAHKFILASRSDYFRKLFLSSLLTSEDavgcDVVHIEKVPPEIFEQLLQFIYTDTCDL 88
BTB_POZ_BTBD1 cd18346
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 88-183 9.16e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 1 (BTBD1); BTBD1, also called Hepatitis C virus NS5A-transactivated protein 8 or HCV NS5A-transactivated protein 8, is a BTB-domain-containing Kelch-like protein that is expressed in skeletal muscle and interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. BTBD1 may serve as substrate-specific adaptor of an E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349655 [Multi-domain]  Cd Length: 133  Bit Score: 54.29  E-value: 9.16e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  88 APAAQFM-AHKVVLASSSPVFKAMFTNGLREQGMEvVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDS 166
Cdd:cd18346  38 GPGAQRIpAHRFVLAAGSAVFDAMFNGGMATTSAE-IELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPA 116

                        90
                ....*....|....*..
gi 45269145 167 VVRACSDFLVQQLDPSN 183
Cdd:cd18346 117 LEAHCVEFLTKHLRADN 133
BTB2_POZ_BTBD8 cd18286
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 69-167 1.12e-08

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349595 [Multi-domain]  Cd Length: 121  Bit Score: 53.42  E-value: 1.12e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  69 ELRLSQQLC--DVTLQVKYQdapaaQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASIS 146
Cdd:cd18286   8 LLQLFLNGEdsDITIKVDGK-----TFKAHRCILCARSSYFAAMLSGSWAESNSSEITLTGVSHAAVSFVLLFIYGGVLD 82

                        90       100
                ....*....|....*....|..
gi 45269145 147 MGEKCVL-HVMNGAVMYQIDSV 167
Cdd:cd18286  83 LPDDVNLgELLSLADMYGLDGL 104
BTB_POZ_ZBTB12 cd18203
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 53-181 1.28e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 12 (ZBTB12); ZBTB12, also called protein G10, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349512 [Multi-domain]  Cd Length: 122  Bit Score: 53.34  E-value: 1.28e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  53 SYTLEDHTKQAFGIMNELRLSQQLCDVTLQvkyqdAPAAQFMAHKVVLASSSPVFKAMFTngLREQGMEVVSIegIH-PK 131
Cdd:cd18203   2 RFQLPGHEAATLRNMNQLRSEERFCDVTIV-----ADSLKFRGHKVVLAACSPFLRDQFL--LNPSSELQVSL--MHsSR 72

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 45269145 132 VMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDP 181
Cdd:cd18203  73 VVADLLLSCYTGALEFSVRDIVNYLTAASYLQMEHVVEKCRGALSQFIEP 122
BTB1_POZ_RhoBTB cd18299
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 67-175 1.46e-08

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349608 [Multi-domain]  Cd Length: 103  Bit Score: 52.60  E-value: 1.46e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  67 MNELRLSQQLCDVTLQVKYQdapaAQFMAHKVVLASSSPVFKAMFTNglreqgMEVVSIEG-IHPKVMERLIEFAYTASI 145
Cdd:cd18299   3 LRNLLHSPSCADVVFILQGG----VRIFAHRIVLAAASSVFADLFLM------MTVVTLDSdITPEAFRRVLEFLYTGVL 72

                        90       100       110
                ....*....|....*....|....*....|
gi 45269145 146 SMGEKCVLHVMNGAVMYQIDSVVRACSDFL 175
Cdd:cd18299  73 DENEDDLKELKDAAELLELFDLVMMCTNVL 102
BTB_POZ_ZBTB22_BING1 cd18210
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 67-175 1.68e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 22 (ZBTB22); ZBTB22, also called protein BING1 or zinc finger protein 297, may be involved in transcriptional regulation. Its gene, together with BING 3-5, TAPASIN, DAXX, RGL2, and HKE2, form a dense cluster at the centromeric end of the major histocompatibility complex class I region. ZBTB22 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349519 [Multi-domain]  Cd Length: 112  Bit Score: 52.92  E-value: 1.68e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  67 MNELRLSQQLCDVTLQVKYQdapaaQFMAHKVVLASSSPVFKamftNGLREQGMEVVSIEGI-HPKVMERLIEFAYTASI 145
Cdd:cd18210  12 LNQQRMEGKLCDISIHVQGR-----VFRAHRAVLAASSPYFH----DQVLLKNMSSISLPGVmDPGAFESVLASAYTGKL 82

                        90       100       110
                ....*....|....*....|....*....|
gi 45269145 146 SMGEKCVLHVMNGAVMYQIDSVVRACSDFL 175
Cdd:cd18210  83 TMLADEIVNYLTVGSVLQMWHIVDKCTELL 112
BTB_POZ_BACH1 cd18277
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 52-175 1.93e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349586 [Multi-domain]  Cd Length: 120  Bit Score: 52.76  E-value: 1.93e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  52 FSYTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYQdapaaQFMAHKVVLASSSPVFKAMFTnGLREQGMEVVSIEGIHPK 131
Cdd:cd18277   3 FAYESSVHSTNVLLSLNDQRKKDVLCDVTILVEGQ-----RFRAHRSVLAACSSYFHSRIV-GQADAELNITLPEEVTVK 76

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 45269145 132 VMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFL 175
Cdd:cd18277  77 GFEPLIQFAYTAKLILSKDNVDEVCKCVEFLSVHNIEESCFQFL 120
BTB_POZ_ZBTB8A_BOZF1 cd18329
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 67-175 2.06e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349638 [Multi-domain]  Cd Length: 116  Bit Score: 52.52  E-value: 2.06e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  67 MNELRLSQQLCDVTLQVKYQdapaaQFMAHKVVLASSSPVFKAMFTNGLREQGMEVV-SIEGIHPKVMERLIEFAYTASI 145
Cdd:cd18329  12 LDEQRKQELFCDCSILVEGQ-----VFKAHRNVLFASSGYFKMLLSQNAKETGQPTVaTFDVFSPDTFTIILDFVYSGKL 86

                        90       100       110
                ....*....|....*....|....*....|
gi 45269145 146 SMGEKCVLHVMNGAVMYQIDSVVRACSDFL 175
Cdd:cd18329  87 SLTSQNVIEVMSAASYLQMTDVISVCKTFI 116
BTB_POZ_ZBTB11 cd18202
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 67-146 3.38e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349511 [Multi-domain]  Cd Length: 118  Bit Score: 52.16  E-value: 3.38e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  67 MNELRLSQQLCDVTLQVKYQdapaaQFMAHKVVLASSSPVFKAMFT-NGLREQGMEVVSIEGIHPKVMERLIEFAYTASI 145
Cdd:cd18202  10 LNQQRLNNQFCDVTLLIEGE-----EYKAHKSVLAANSEYFRELFIeKGAVSSHEAVVDLSGFCKSSFLPLLEFAYTSEL 84


                .
gi 45269145 146 S 146
Cdd:cd18202  85 T 85
PHA02713 PHA02713
hypothetical protein; Provisional
 76-555 3.86e-08

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 56.17  E-value: 3.86e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145   76 LCDVTLQVKyqdaPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEV-VSIEGIHPKVMERLIEFAYTASISmgEKCVLH 154
Cdd:PHA02713  25 LCDVIITIG----DGEEIKAHKTILAAGSKYFRTLFTTPMIIRDLVTrVNLQMFDKDAVKNIVQYLYNRHIS--SMNVID 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  155 VMNGAVMYQIDSVVRACSDFlvqqldpsnaigIANFAEQIGCVELHQRAREYIYMHFGEVAKQ------------EEFFN 222
Cdd:PHA02713  99 VLKCADYLLIDDLVTDCESY------------IKDYTNHDTCIYMYHRLYEMSHIPIVKYIKRmlmsniptlittDAFKK 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  223 LSHCQLVTLISRDDlNVRCESEVFHACI--NWVKYD--------CEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQ 292
Cdd:PHA02713 167 TVFEILFDIISTND-NVYLYREGYKVTIllKWLEYNyiteeqllCILSCIDIQNLDKKSRLLLYSNKTINMYPSCIQFLL 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  293 SDSR------------CKD------------YLVKIFEELTLHK-PTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAY-- 345
Cdd:PHA02713 246 DNKQnrniiprqlclvCHDtkynvcnpcilvYNINTMEYSVISTiPNHIINYASAIVDNEIIIAGGYNFNNPSLNKVYki 325

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  346 NPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNnspdGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHI 425
Cdd:PHA02713 326 NIENKIHVELPPMIKNRCRFSLAVIDDTIYAIGGQN----GTNVERTIECYTMGDDKWKMLPDMPIALSSYGMCVLDQYI 401

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  426 YAVGGS-----HGCIHH-------------NSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVggFDGTNRLNSA 487
Cdd:PHA02713 402 YIIGGRtehidYTSVHHmnsidmeedthssNKVIRYDTVNNIWETLPNFWTGTIRPGVVSHKDDIYVV--CDIKDEKNVK 479

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 45269145  488 ECYY----PERNEWRMITAMNTiRSGAGVCVLH-NCIYAAGGYDG---QDQLNsverydVETETWTFVApmkHRRS 555
Cdd:PHA02713 480 TCIFryntNTYNGWELITTTES-RLSALHTILHdNTIMMLHCYESymlQDTFN------VYTYEWNHIC---HQHS 545
BTB_POZ_BACH cd18955
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 76-175 4.04e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349736 [Multi-domain]  Cd Length: 94  Bit Score: 51.32  E-value: 4.04e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  76 LCDVTLQVKYQdapaaQFMAHKVVLASSSPVFKAMFTNGLREQGM----EVVSIEGIHPkvmerLIEFAYTASISMGEKC 151
Cdd:cd18955   1 LCDVTIVVEDQ-----RFRAHRAVLAACSDYFLSRVVGQTDGDLVitlpEEVTVKGFEP-----LLQFAYTAKLLLSKEN 70

                        90       100
                ....*....|....*....|....
gi 45269145 152 VLHVMNGAVMYQIDSVVRACSDFL 175
Cdd:cd18955  71 VLEVCRCAEFLGVHNIEKACFDFL 94
BTB_POZ_ZBTB14 cd18204
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 59-172 5.88e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14); ZBTB14 is also called zinc finger protein 161 (Zfp-161), zinc finger protein 478, zinc finger protein 5 (ZF5), or Zfp-5. It is a novel transcriptional activator of the dopamine transporter, binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. It also binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. ZBTB14 acts as a transcriptional repressor of MYC and thymidine kinase promoters. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349513 [Multi-domain]  Cd Length: 114  Bit Score: 51.19  E-value: 5.88e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  59 HTKQAFGIMNELRLSQQLCDVTLQVKyqdapAAQFMAHKVVLASSSPVFKAMFTNgLREQGMEVVSIEGIHPKVMERLIE 138
Cdd:cd18204   1 HKTVFLKTLNEQRLEGEFCDIAIVVE-----DVKFRAHRCVLAACSTYFKKLFKK-LEVDSSSVIEIDFLRSDIFEEVLN 74

                        90       100       110
                ....*....|....*....|....*....|....
gi 45269145 139 FAYTASISMGEKCVLHVMNGAVMYQIDSVVRACS 172
Cdd:cd18204  75 YMYTAKISVKKEDVNLMMSSGQILGIRFLDKLCS 108
BTB_POZ_ZBTB31_myoneurin cd18217
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 59-171 7.13e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349526 [Multi-domain]  Cd Length: 111  Bit Score: 50.91  E-value: 7.13e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  59 HTKQAFGIMNELRLSQQLCDVTLQVKyqdapAAQFMAHKVVLASSSPVFKAMFtnglREQGMEVVSI--EGIHPKVMERL 136
Cdd:cd18217   1 HCEQLLERLNKQREAGFLCDCTIVIG-----QFQFKAHRNVLAAFSEYFGAQY----KDTEDNIVFLdqSQVSADGFQKL 71

                        90       100       110
                ....*....|....*....|....*....|....*
gi 45269145 137 IEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRAC 171
Cdd:cd18217  72 LEFIYTGNLNLDSWNVAEIHQAASYLGMEEVVAKC 106
BTB_POZ_ABTB2_BPOZ2 cd18350
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 73-185 7.26e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2); ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins with various functions ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. It inhibits the aggregation of alpha-synuclein, with implications for Parkinson's disease. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. It is also involved in the growth suppressive effect of the phosphatase and tensin homolog (PTEN). It contains an ankyrin repeat, BTB/POZ, and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349659 [Multi-domain]  Cd Length: 134  Bit Score: 51.77  E-value: 7.26e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  73 SQQLCDVTLQVKyqdapAAQFMAHKVVLASSSPVFKAMFTN--GLREQGMEVVSIEGIHPKVMERLIEFAY---TASISM 147
Cdd:cd18350  21 NKEMSDVTFLVE-----GKLFYAHKVLLVTASNRFKSLLTNksEQESQGSKTIEISDIKYHIFQMLMQYLYyggTESMEI 95

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 45269145 148 GEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAI 185
Cdd:cd18350  96 PIADVLELLSAASLFQLDALQRHCEILCSQTINLENAV 133
BTB_POZ_KLHL11 cd18241
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 68-183 8.11e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349550 [Multi-domain]  Cd Length: 135  Bit Score: 51.40  E-value: 8.11e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  68 NELRLSQQLCDVTLqvKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIE------GIHPKVMERLIEFAY 141
Cdd:cd18241  15 NEQRKQGLFCDITL--AFGGAGGREFRAHRSVLAAATEYFTPLLSGQFSESRSGRVEMRkwssepGPDPDTVEAVIQYMY 92

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 45269145 142 TASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSN 183
Cdd:cd18241  93 TGRIRVSTGNVHEVLELADRFLLIRLKEFCGEFLKKKLNLSN 134
BTB_POZ_ZBTB20_DPZF cd18208
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 56-177 8.68e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20); ZBTB20, also called dendritic-derived BTB/POZ zinc finger protein (DPZF) or zinc finger protein 288, may be a transcription factor involved in hematopoiesis, oncogenesis, and immune responses. It is an essential regulator of hepatic lipogenesis and may be a therapeutic target for the treatment of fatty liver disease. It also functions as a critical regulator of anterior pituitary development and lactotrope specification. Moreover, it promotes astrocytogenesis during neocortical development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349517 [Multi-domain]  Cd Length: 117  Bit Score: 50.83  E-value: 8.68e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  56 LEDHTKQAFGIMNELRLSQQLCDVTLQVKyqdapAAQFMAHKVVLASSSPVFKAMFTNGLREqgMEVVSIEGIHPkvMER 135
Cdd:cd18208   5 LHNFSNSVLETLNEQRNRGHFCDVTVRIH-----GSMLRAHRCVLAAGSPFFQDKLLLGYSD--IEIPSVVSVQS--VQK 75

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 45269145 136 LIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQ 177
Cdd:cd18208  76 LIDFMYSGVLRVSQSEALQILTAASILQIKTVIDECTRIVSQ 117
BTB_POZ_ZBTB32_FAZF_TZFP cd18218
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 69-171 1.12e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 32 (ZBTB32); ZBTB32 is also called FANCC-interacting protein, fanconi anemia zinc finger protein (FAZF), testis zinc finger protein (TZFP), or zinc finger protein 538 (ZNF538). It is a DNA-binding transcription factor that binds to the 5'-TGTACAGTGT-3' core sequence. It acts as a transcription suppressor that controls T cell-mediated autoimmunity. ZBTB32 is essential for down-regulation of GATA3 via ZPO2; this promotes aggressive breast cancer development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349527 [Multi-domain]  Cd Length: 110  Bit Score: 50.32  E-value: 1.12e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  69 ELRLSQQLCDVTLQVKYQDapaaqFMAHKVVLASSSPVFKAMFTNGLREQgmeVVSIEGIHPKVMERLIEFAYTASISMG 148
Cdd:cd18218  11 RLRPAGALCDTLITVGSQE-----FPAHSLVLAGASQQLGRQLTNPNPGQ---WCLGEGISPSTFKQLLDFVYGESVEVQ 82

                        90       100
                ....*....|....*....|...
gi 45269145 149 EKCVLHVMNGAVMYQIDSVVRAC 171
Cdd:cd18218  83 PGELRPLLEAARALEVESLEEAC 105
BTB_POZ_BTBD6 cd18349
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 95-179 2.42e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 6 (BTBD6); BTBD6, also termed lens BTB domain protein, is a BTB-domain-containing Kelch-like protein required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349658 [Multi-domain]  Cd Length: 109  Bit Score: 49.60  E-value: 2.42e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  95 AHKVVLASSSPVFKAMFTNGLREQGMEvVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDF 174
Cdd:cd18349  26 AHKYVLAVGSSVFYAMFYGDLAEVKSE-IHIPDVEPAAFLILLKYMYSDEIDLEADTVLATLYAAKKYIVPALAKACVNF 104


                ....*
gi 45269145 175 LVQQL 179
Cdd:cd18349 105 LETSL 109
BACK_KLHL31_KBTBD1 cd18470
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also ...
 183-272 2.58e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also termed BTB and kelch domain-containing protein 6, or Kelch repeat and BTB domain-containing protein 1, or Kelch-like protein KLHL, is a transcriptional repressor in MAPK/JNK signaling pathway that regulates cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE).


Pssm-ID: 350545  Cd Length: 98  Bit Score: 49.10  E-value: 2.58e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145 183 NAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDcEQRRF 262
Cdd:cd18470   5 NCMYVVNIAETYGLKNTKEAAQKFIRDNFIEFSETDQFLKLTFEQINEFLIDDDLQLPSEITAFQIAMKWLDFD-QKRVK 83

                        90
                ....*....|
gi 45269145 263 YVQALLRAVR 272
Cdd:cd18470  84 YAADLLSNIR 93
BTB_POZ_BTBD2 cd18347
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 63-183 2.65e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 2 (BTBD2); BTBD2 is a BTB-domain-containing Kelch-like protein that interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349656 [Multi-domain]  Cd Length: 127  Bit Score: 49.69  E-value: 2.65e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  63 AFGIMNELrlsqqLCDVTLQVKyQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVvSIEGIHPKVMERLIEFAYT 142
Cdd:cd18347  14 AFLFNNEV-----LSDVHFLVG-KGLGSQRIPAHRFVLAVGSAVFDAMFNGGMATTSTEI-ELPDVEPAAFLALLKFLYS 86

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 45269145 143 ASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSN 183
Cdd:cd18347  87 DEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADN 127
BTB_POZ_KLHL14_printor cd18243
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-183 4.02e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14); KLHL14 is also called protein interactor of Torsin-1A (TOR1A), protein interactor of torsinA, or Printor. It is a novel torsinA-interacting protein that preferentially interacts with ATP-free form of TOR1A and is implicated in dystonia pathogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349552 [Multi-domain]  Cd Length: 130  Bit Score: 49.27  E-value: 4.02e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  45 SQHGNRTFSYTlEDHTKQAFGIMNELRLSQQLCDVTLQVKYQdapaaQFMAHKVVLASSSPVFKAMFT-NGLREQGMEVV 123
Cdd:cd18243   2 SRSGDRTSTFD-PSHSDNLLHGLNLLWRKQLFCDVTLTAQGQ-----QFHCHKAVLASCSQYFRSLFSiNNLVLQGCSSI 75

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145 124 SIEGIhpkvmerlIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSN 183
Cdd:cd18243  76 GLRLV--------LEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQN 127
BTB_POZ_ZBTB16_PLZF cd18205
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 68-175 4.11e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 16 (ZBTB16); ZBTB16 is also called promyelocytic leukemia zinc finger protein, zinc finger protein 145, or zinc finger protein PLZF. It is a DNA-binding transcription factor essential for undifferentiated cell maintenance. ZBTB16 also acts as a downstream transcriptional regulator of Osterix and can be useful as a late marker of osteoblastic differentiation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349514 [Multi-domain]  Cd Length: 107  Bit Score: 48.88  E-value: 4.11e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  68 NELRLSQQLCDVTLQVKYQdapaaQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSiegihPKVMERLIEFAYTASISM 147
Cdd:cd18205  10 NQMRLAGTLCDVVIMVDSQ-----EFHAHRTVLACTSKMFEILFHRNSQHYTLDFLS-----PKTFQQILEYAYTATLQA 79

                        90       100
                ....*....|....*....|....*...
gi 45269145 148 GEKCVLHVMNGAVMYQIDSVVRACSDFL 175
Cdd:cd18205  80 KVEDLDDLLYAAEILEIEYLEEQCLKIL 107
Kelch_6 pfam13964
Kelch motif;
506-554 4.19e-07

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 46.94  E-value: 4.19e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 45269145   506 IRSGAGVCVLHNCIYAAGGYDGQDQ-LNSVERYDVETETWTFVAPMKHRR 554
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYTNASPaLNKLEVYNPLTKSWEELPPLPTPR 50
BTB_POZ_ZBTB8 cd18199
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 59-175 6.18e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349508 [Multi-domain]  Cd Length: 113  Bit Score: 48.19  E-value: 6.18e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  59 HTKQAFGIMNELRLSQQLCDVTLQVKYQdapaaQFMAHKVVLASSSPVFKAMFTNGLREQGMEVV-SIEGIHPKVMERLI 137
Cdd:cd18199   1 HQSRLLGQLNEQRKQDFFCDCSIIVEGR-----IFKAHRNVLFASSGYFRMLLSHYIQDTGRPSTaSFDVFSSDAFSIIL 75

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 45269145 138 EFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFL 175
Cdd:cd18199  76 DFVYSGKLSLTSQNVIEVMSAASYLQMTDVINVCKTFI 113
BACK_calicin cd18503
BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal ...
 179-255 7.97e-07

BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa.


Pssm-ID: 350578 [Multi-domain]  Cd Length: 78  Bit Score: 46.96  E-value: 7.97e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 45269145 179 LDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKY 255
Cdd:cd18503   1 LDRDNCLTALCLATTAGLKDLSDEIYDYIRDNFFDVSGTREFLQCPYDIFSRLLKDENLHVNNEDQVLLALLNWTEH 77
Kelch_3 pfam13415
Galactose oxidase, central domain;
564-608 9.71e-07

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 45.74  E-value: 9.71e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 45269145   564 GRIYVLGGYD--GHTFLDSVECYDPDTDTWSEVTRMTSGRSGVGVAV 608
Cdd:pfam13415   2 DKLYIFGGLGfdGQTRLNDLYVYDLDTNTWTQIGDLPPPRSGHSATY 48
BTB_POZ_ZBTB3-like cd18194
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 58-171 1.08e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349503 [Multi-domain]  Cd Length: 128  Bit Score: 48.28  E-value: 1.08e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  58 DHTKQAFGIMNELRLSQQLCDVTLQVKyqdapAAQFMAHKVVLASSSPVFKAMFTNglREQGMEVVSIEG--IHPKVMER 135
Cdd:cd18194   5 EHSRQLLQCLREQRSQGFLCDCTVLVG-----SAQFPAHRAVLASCSMYFHLFYRD--RLDKRDLVRLNSdiVTAPAFGL 77

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 45269145 136 LIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRAC 171
Cdd:cd18194  78 LLDFMYEGRLALRDLPVEDVLAAASYLHMYDIVKVC 113
BTB_POZ_ZBTB40 cd18225
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 56-175 1.11e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 40 (ZBTB40); ZBTB40 may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB40 are associated with bone mineral density in European and East-Asian populations. ZBTB40 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349534 [Multi-domain]  Cd Length: 116  Bit Score: 47.90  E-value: 1.11e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  56 LEDHTKQAFGIMNELRLSQQLCDVTLQVKyqdapAAQFMAHKVVLASSSPVFKAMFtnglreQGMEVVSIEG--IHPKVM 133
Cdd:cd18225   3 LPNYSRQLLQQLHTLRKEQQFCDCTIFIG-----TFHFRAHKLVLAASSLLFKSLL------DSTDTISIDAsvVSPEEF 71

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 45269145 134 ERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFL 175
Cdd:cd18225  72 ALLLEMVYTGKLPPGKHNFTKIISVADSLQMFDVAVSCKNLL 113
PHA02713 PHA02713
hypothetical protein; Provisional
 514-608 1.54e-06

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 51.16  E-value: 1.54e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  514 VLHNCIYAAGGYDGQD-QLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWS 592
Cdd:PHA02713 301 IVDNEIIIAGGYNFNNpSLNKVYKINIENKIHVELPPMIKNRCRFSLAVIDDTIYAIGGQNGTNVERTIECYTMGDDKWK 380

                         90
                 ....*....|....*.
gi 45269145  593 EVTRMTSGRSGVGVAV 608
Cdd:PHA02713 381 MLPDMPIALSSYGMCV 396
Kelch_6 pfam13964
Kelch motif;
554-601 1.64e-06

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 45.40  E-value: 1.64e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 45269145   554 RSALGITVHQGRIYVLGGY-DGHTFLDSVECYDPDTDTWSEVTRMTSGR 601
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGYtNASPALNKLEVYNPLTKSWEELPPLPTPR 50
BTB_POZ_ZBTB39 cd18224
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 58-145 1.91e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 39 (ZBTB39); ZBTB39 may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349533 [Multi-domain]  Cd Length: 123  Bit Score: 47.13  E-value: 1.91e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  58 DHTKQAFGIMNELRLSQQLCDVTLQVKYQdapaaQFMAHKVVLASSSPVFKAMFTNglreQGMEVV---SIEGIHPKVME 134
Cdd:cd18224   8 DHPNNLLKELNKCRLSETMCDVTIVVGNR-----SFAAHKAVLACAAGYFQKLFLS----TELDVArtyVVDFITPANFE 78

                        90
                ....*....|.
gi 45269145 135 RLIEFAYTASI 145
Cdd:cd18224  79 KVLSFIYTSEL 89
BTB_POZ_BTBD3 cd18348
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 95-184 2.63e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 3 (BTBD3); BTBD3 is a BTB-domain-containing Kelch-like protein that controls dendrite orientation toward active axons in the mammalian neocortex. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349657 [Multi-domain]  Cd Length: 131  Bit Score: 46.94  E-value: 2.63e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  95 AHKVVLASSSPVFKAMFTNGLREQGMEVvSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDF 174
Cdd:cd18348  39 GHKYVLAVGSSVFHAMFYGELAEDKDEI-RIPDVEPAAFLAMLKYIYCDEIDLAADTVLATLYAAKKYIVPHLARACVNF 117

                        90
                ....*....|
gi 45269145 175 LVQQLDPSNA 184
Cdd:cd18348 118 LETSLSAKNA 127
BTB_POZ_ZBTB10 cd18201
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 67-180 2.82e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349510 [Multi-domain]  Cd Length: 122  Bit Score: 46.87  E-value: 2.82e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  67 MNELRLSQQLCDVTLQVKYQdapaaQFMAHKVVLASSSPVFKAM--FTNG-LREQG----MEVVSIEGihpkvMERLIEF 139
Cdd:cd18201  12 LNEQRKKGILCDVNIVVSGK-----VFRAHKNILVAGSRFFKTLycFTNKeSCDQTtvthLDVVAVQG-----FSVILDF 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 45269145 140 AYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLD 180
Cdd:cd18201  82 MYSGNLVLTSQNAIEVMSVASYLQMTEVVQSCRNFIKDALN 122
PLN02193 PLN02193
nitrile-specifier protein
 370-571 3.67e-06

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 49.95  E-value: 3.67e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  370 VGGLLYAVGGRNnSPDGNTDSSaLDCYNPMTNQWSpCAPMS--VPR-NRIGVGV--IDGHIYAVGGSHGCIHHNSVERYE 444
Cdd:PLN02193 174 VGNKIYSFGGEF-TPNQPIDKH-LYVFDLETRTWS-ISPATgdVPHlSCLGVRMvsIGSTLYVFGGRDASRQYNGFYSFD 250

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  445 PERDEWHLVAPM---LTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMN---TIRSGAGVCVLHNC 518
Cdd:PLN02193 251 TTTNEWKLLTPVeegPTPRSFHSMAADEENVYVFGGVSATARLKTLDSYNIVDKKWFHCSTPGdsfSIRGGAGLEVVQGK 330

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 45269145  519 IYAAGGYDGQdQLNSVERYDVETETWTFVAPMKHR---RSALGITVHQGRIYVLGG 571
Cdd:PLN02193 331 VWVVYGFNGC-EVDDVHYYDPVQDKWTQVETFGVRpseRSVFASAAVGKHIVIFGG 385
BTB_POZ_ZBTB4 cd18195
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 67-147 4.69e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4); ZBTB4, also called KAISO-like zinc finger protein 1 (KAISO-L1), is a transcriptional repressor with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. ZBTB4 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349504 [Multi-domain]  Cd Length: 124  Bit Score: 46.04  E-value: 4.69e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  67 MNELRLSQQLCDVTLQvkyqdAPAAQFMAHKVVLASSSPVFK-------------AMFTNGLREQGMEVVSIEGIHPKVM 133
Cdd:cd18195   9 LNEQRLRGLFCDVTLI-----AGDTKFRAHRSVLAASSPYFRellssplplgaaaVAAAPGATQSPERVLELPGVKAGVF 83

                        90
                ....*....|....
gi 45269145 134 ERLIEFAYTASISM 147
Cdd:cd18195  84 SDVLNFIYSSRVAL 97
BTB_POZ_ZBTB38_CIBZ cd18223
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 59-150 6.24e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349532 [Multi-domain]  Cd Length: 114  Bit Score: 45.55  E-value: 6.24e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  59 HTKQAFGIMNELRLSQQLCDVTLQVKyqdapAAQFMAHKVVLASSSPVFKAMFTN-GLREQGmEVVSIEGIHPKVMERLI 137
Cdd:cd18223   1 HSDTVLSCLNEQRIQGILCDVTIVVE-----DTKFKAHKNVLAASSLYFKNAFSSqEIWISS-HVLELPDLKAEVFAEIL 74

                        90
                ....*....|...
gi 45269145 138 EFAYTASISMGEK 150
Cdd:cd18223  75 NFIYSSKVVVKRQ 87
BTB_POZ_ZBTB18_RP58 cd18324
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 58-178 7.17e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349633 [Multi-domain]  Cd Length: 147  Bit Score: 46.18  E-value: 7.17e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  58 DHTKQAFGIMNELRLSQQLCDVTLQVKyqdapAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLI 137
Cdd:cd18324   5 DHSRHLLQCLSEQRHQGFLCDCTVLVG-----DAQFRAHRAVLASCSMYFHLFYKDQLDKRDIVHLNSDIVTAPAFALLL 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 45269145 138 EFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQ 178
Cdd:cd18324  80 EFMYEGKLQFKDLPIEDVLAAASYLHMYDIVKVCKKKLKEK 120
Kelch_2 pfam07646
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 553-597 7.85e-06

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 462220 [Multi-domain]  Cd Length: 47  Bit Score: 43.09  E-value: 7.85e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 45269145   553 RRSALGITVHQGRIYVLGGYDGH--TFLDSVECYDPDTDTWSEVTRM 597
Cdd:pfam07646   1 PRYPHASSVPGGKLYVVGGSDGLgdLSSSDVLVYDPETNVWTEVPRL 47
BTB_POZ cd01165
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 79-142 8.97e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


Pssm-ID: 349496 [Multi-domain]  Cd Length: 79  Bit Score: 44.19  E-value: 8.97e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 45269145  79 VTLQVKYQdapaaQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYT 142
Cdd:cd01165   1 VVLVVEGE-----KFHVNKELLAQSSEYFRALFRGGFRESGQAEINLRDISPEDFRALLEFLYG 59
BTB_POZ_ZBTB18_2-like cd18325
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 58-171 1.17e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18.2 and similar proteins; This subfamily is composed of Xenopus laevis zinc finger and BTB domain-containing protein 18.2, encoded by the znf238.2.L gene, and similar proteins. Many proteins in this group are annotated as zinc finger and BTB domain-containing protein 42 (ZBTB42). However, characterized mammalian ZBTB42 does not belong to this subfamily. ZBTB18.2, like ZBTB18, functions as a transcriptional repressor that plays a role in various developmental processes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349634 [Multi-domain]  Cd Length: 128  Bit Score: 45.03  E-value: 1.17e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  58 DHTKQAFGIMNELRLSQQLCDVTLQVKyqdapAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLI 137
Cdd:cd18325   5 DHSRQLLQCLSQQRHQGFLCDCTVLVG-----EAQFRAHRAVLASCSMYFHLFYRDQLDKRDIVHLNSDIVTAPAFSLLL 79

                        90       100       110
                ....*....|....*....|....*....|....
gi 45269145 138 EFAYTASISMGEKCVLHVMNGAVMYQIDSVVRAC 171
Cdd:cd18325  80 EFMYEGKLEFSSLPVEDVLAAASYLHMYDIVKVC 113
BTB_POZ_ZBTB30_HIC2 cd18334
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 56-145 1.20e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349643 [Multi-domain]  Cd Length: 120  Bit Score: 44.96  E-value: 1.20e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  56 LEDHTKQAFGIMNELRLSQQLCDVTLQVKyqdapAAQFMAHKVVLASSSPVFKAMftngLREQGMEVVSIEGIHPKVMER 135
Cdd:cd18334   1 LPNHAKQLLLQLNQQRAKGFLCDVIIVVE-----NALFRAHKNILAASSMYFKSL----VLHDNLINLDTDMVNPTVFRQ 71

                        90
                ....*....|
gi 45269145 136 LIEFAYTASI 145
Cdd:cd18334  72 ILDFIYTGKL 81
BTB_POZ_BACH2 cd18278
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 67-175 1.21e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349587 [Multi-domain]  Cd Length: 124  Bit Score: 44.94  E-value: 1.21e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  67 MNELRLSQQLCDVTLQVKyqdapAAQFMAHKVVLASSSPVFKAMFTnGLREQGMEVVSIEGIHPKVMERLIEFAYTASIS 146
Cdd:cd18278  22 LNDQRKQDILCDVTLIVE-----GKEFRAHRAVLAACSEYFLQALV-GQTENDLVVSLPEEVTARGFGPLLQFAYTAKLL 95

                        90       100
                ....*....|....*....|....*....
gi 45269145 147 MGEKCVLHVMNGAVMYQIDSVVRACSDFL 175
Cdd:cd18278  96 LSRENIQEVIRCAEFLRMHNLEDSCFRFL 124
Kelch_6 pfam13964
Kelch motif;
361-413 1.26e-05

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 42.71  E-value: 1.26e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 45269145   361 PRSGLAGCVVGGLLYAVGGRNNspdGNTDSSALDCYNPMTNQWSPCAPMSVPR 413
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYTN---ASPALNKLEVYNPLTKSWEELPPLPTPR 50
BTB_POZ_ZBTB8B cd18330
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 64-175 1.30e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349639 [Multi-domain]  Cd Length: 113  Bit Score: 44.53  E-value: 1.30e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  64 FGIMNELRLSQQLCDVTLQVKyqdapAAQFMAHKVVLASSSPVFKAMFTNGLREQGM-EVVSIEGIHPKVMERLIEFAYT 142
Cdd:cd18330   6 LGELNEQRKRDFFCDCSIIVE-----GRIFKAHRNILFANSGYFRALLIHYIQDSGRhSTASLDIVTSEAFSIILDFLYS 80

                        90       100       110
                ....*....|....*....|....*....|...
gi 45269145 143 ASISMGEKCVLHVMNGAVMYQIDSVVRACSDFL 175
Cdd:cd18330  81 GKLDLCSENVIEVMSAASYLQMTDVVNFCKGYI 113
BTB_POZ_ZBTB9 cd18200
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 67-175 1.99e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 9 (ZBTB9); ZBTB9 may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349509 [Multi-domain]  Cd Length: 111  Bit Score: 44.07  E-value: 1.99e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  67 MNELRLSQQLCDVTLQVKYQdapaaQFMAHKVVLASSSPVFKAMFtngLREQGMEVVSIEGIHPKVMERLIEFAYTASIS 146
Cdd:cd18200   9 LNKHRLEGKFCDLSVHVQGR-----VFRAHKAVLAASSPYFHDKL---LLNDTNCLVLPSVIEAAAFENLLQLIYSGRLT 80

                        90       100       110
                ....*....|....*....|....*....|..
gi 45269145 147 MGEKCV---LHVMNGAVMYQidsVVRACSDFL 175
Cdd:cd18200  81 LCMDALpshLLVASGLQMWQ---VVDRCSELL 109
BACK_BTBD17 cd18493
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); ...
 198-253 2.24e-05

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also termed galectin-3-binding protein-like, is a BTB-domain-containing Kelch-like protein. Its function remains unclear. It may be involved in hepatocellular carcinoma development and progression.


Pssm-ID: 350568  Cd Length: 74  Bit Score: 42.57  E-value: 2.24e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 45269145 198 ELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWV 253
Cdd:cd18493  19 ELAEACLEFIAWNFEKVLKSPDWLNLDLDLLVSLLQSSDLVVEDEYTLFQAVEKWL 74
BTB_POZ_ZBTB26_Bioref cd18214
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 54-181 2.51e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 26 (ZBTB26); ZBTB26, also called zinc finger protein 481 (ZNF481) or zinc finger protein Bioref, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349523 [Multi-domain]  Cd Length: 122  Bit Score: 44.05  E-value: 2.51e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  54 YTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYQDAPaaqfmAHKVVLASSSPVFKAMFTngLREQGMEVVSIEGiHPKVM 133
Cdd:cd18214   3 FRFENYGDSMLQKMNKLREQNKFCDVTVHIDDLEVP-----GHKVVFAAGSPFLRDQFL--LNDSREVQISILQ-NSEVG 74

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 45269145 134 ERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDP 181
Cdd:cd18214  75 RQLLLSCYTGVLEFPEMELVNYLTAASFLQMSHIVERCTQALWKFIKP 122
BACK_BTBD3_like cd18488
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing proteins, BTBD3 and ...
 198-260 2.62e-05

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This subfamily includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionarily-conserved role during neuronal development.


Pssm-ID: 350563  Cd Length: 95  Bit Score: 43.12  E-value: 2.62e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 45269145 198 ELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRcESEVFHACINWVKYDCEQR 260
Cdd:cd18488  20 ELMQRCWEVIDAQAELALKSEGFTEIDYKTLESILRRETLNAK-ESVVFEAALRWAEAECQRR 81
BACK_KLHL26 cd18465
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a ...
 185-278 2.68e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a kelch family protein encoded by gene klhl26, which is regulated by p53 via fuzzy tandem repeats.


Pssm-ID: 350540  Cd Length: 97  Bit Score: 43.36  E-value: 2.68e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145 185 IGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCEQRRFYV 264
Cdd:cd18465   7 LNIGQMATTFSLASLKESVDAFTFRHFLQIAEEEDFLHLPLERLVFFLQSNKLKNCSEIDLFRAAIRWLQHDPSRRASAS 86

                        90
                ....*....|....
gi 45269145 265 QALlravrCHSLTP 278
Cdd:cd18465  87 HVL-----CHIRFP 95
BTB_POZ_ZBTB41 cd18226
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 59-149 2.78e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41); ZBTB41, also called FRBZ1, may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349535 [Multi-domain]  Cd Length: 114  Bit Score: 43.63  E-value: 2.78e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  59 HTKQAFGIMNELRLSQ-QLCDVTLQVKyqdapAAQFMAHKVVLASSSPVFKAMFTnglREQGMEVVSIEGIHPKVMERLI 137
Cdd:cd18226   4 YNKNLLKYLNDDRQKQsSFCDLVITVE-----GKEFSAHKVVVAVGSSYFHACLS---KNPNTDAVTLDHVSYSVFQHLL 75

                        90
                ....*....|..
gi 45269145 138 EFAYTASISMGE 149
Cdd:cd18226  76 EFLYTSEFFVYE 87
BTB_POZ_ZBTB49 cd18233
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 67-175 2.81e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49); ZBTB49, also called zinc finger protein 509 (ZNF509), is a transcription factor that inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. There are four ZNF509 isoforms generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). ZBTB49 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349542 [Multi-domain]  Cd Length: 112  Bit Score: 43.73  E-value: 2.81e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  67 MNELRLSQQLCDVTLQVKyqdapAAQFMAHKVVLASSSPVFKAMFTNGlREQGMEVVSIEGIHPKVMERLIEFAYTASIS 146
Cdd:cd18233   9 LHEQRIQGLLCDCMLVVK-----GVCFKAHKNVLAAFSQYFRSLFQNS-SSQKNDVFHLDIKNVGGIGQILDFMYTSHLD 82

                        90       100
                ....*....|....*....|....*....
gi 45269145 147 MGEKCVLHVMNGAVMYQIDSVVRACSDFL 175
Cdd:cd18233  83 LNQDNVQVMLDIAQCLQVQNVLNMCYTFL 111
BTB_POZ_KBTBD11 cd18275
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 95-183 3.06e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11 is also called chronic myelogenous leukemia-associated protein (CMLAP) or Kelch domain-containing protein 7B, or KLHDC7C. It is a BTB-Kelch family protein whose function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349584 [Multi-domain]  Cd Length: 104  Bit Score: 43.24  E-value: 3.06e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  95 AHKVVLASSSPVFKAMFTNglreqgmEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDF 174
Cdd:cd18275  18 AHKSVLAAKSDYFRARLSR-------DILKVKGLSYATLRLLVDYVYSGRMAVSKDNVVEVVAGARFLQMPCAAQCAVDA 90


                ....*....
gi 45269145 175 LVQQLDPSN 183
Cdd:cd18275  91 VRAQLCLGN 99
PLN02153 PLN02153
epithiospecifier protein
 412-594 4.02e-05

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 46.13  E-value: 4.02e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  412 PRNRIGVGVIDGHIYAVGGSHGCIHHNSVERY--EPERDEWHLV-----APMLTRrIGVGVAVLNRLLYAVGGFDGTNRL 484
Cdd:PLN02153  22 PRCSHGIAVVGDKLYSFGGELKPNEHIDKDLYvfDFNTHTWSIApangdVPRISC-LGVRMVAVGTKLYIFGGRDEKREF 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  485 NSAECYYPERNEWRMITAMNTI-----RSGAGVCVLHNCIYAAGG------YDGQDQLNSVERYDVETETWTFVA-PMKH 552
Cdd:PLN02153 101 SDFYSYDTVKNEWTFLTKLDEEggpeaRTFHSMASDENHVYVFGGvskgglMKTPERFRTIEAYNIADGKWVQLPdPGEN 180

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 45269145  553 --RRSALGITVHQGRIYVL---------GGYDGHTFlDSVECYDPDTDTWSEV 594
Cdd:PLN02153 181 feKRGGAGFAVVQGKIWVVygfatsilpGGKSDYES-NAVQFFDPASGKWTEV 232
BTB_POZ_ZBTB48_TZAP_KR3 cd18232
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 59-174 4.50e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349541 [Multi-domain]  Cd Length: 108  Bit Score: 42.82  E-value: 4.50e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  59 HTKQAFGIMNELRLSQQLCDVTLQVKyqdapAAQFMAHKVVLASSSPVFKAMFTNGLreqGMEVVSIEGIhPKVMERLIE 138
Cdd:cd18232   1 HSVKVLQALNKQREEGQYCDATLDVG-----GRVFKAHWSVLACCSHFFQSLYGDGT---SGSVVLPESF-AEVFGLLLD 71

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 45269145 139 FAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDF 174
Cdd:cd18232  72 FFYTGELALTRENRDRVLLAAKELRVPEAVELCQRF 107
BTB_POZ_BT cd18313
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 93-179 5.59e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana BTB/POZ and TAZ domain-containing proteins, BT1-5; BT1-5 may act as substrate-specific adaptors of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. They contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349622 [Multi-domain]  Cd Length: 102  Bit Score: 42.46  E-value: 5.59e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  93 FMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGE--KCVLHVMNGAVMYQIDSVVRA 170
Cdd:cd18313  14 IPAHSNVLASASPVIAGMLKQPRRKSSKKVIKILGVPCDAVRVFIRFLYSSCYEEEEmeKFGIHLLVLSHVYVVPQLKRV 93


                ....*....
gi 45269145 171 CSDFLVQQL 179
Cdd:cd18313  94 CEKGLEQGL 102
BACK_KLHL11 cd18451
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a ...
 179-265 8.70e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.


Pssm-ID: 350526 [Multi-domain]  Cd Length: 88  Bit Score: 41.48  E-value: 8.70e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145 179 LDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCE 258
Cdd:cd18451   1 LNLSNCVAIHSLAHMYSLDQLALKAADMIRRNFHKVIQDEEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVLKWVQRNAE 80


                ....*..
gi 45269145 259 QRRFYVQ 265
Cdd:cd18451  81 ERERYFE 87
BTB_POZ_ZBTB6 cd18197
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 67-175 9.63e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 6 (ZBTB6); ZBTB6, also called zinc finger protein 482 (ZNF482) or zinc finger protein with interaction domain, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349506 [Multi-domain]  Cd Length: 116  Bit Score: 42.16  E-value: 9.63e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  67 MNELRLSQQLCDVTLQVKyqdapAAQFMAHKVVLASSSPVFKAMFtngLREQGMEVVSIEGIHPKVMERLIEFAYTASIS 146
Cdd:cd18197  16 MNLLRQQNLFCDVSIYIN-----DTEFHGHKVILAACSTFMRDQF---LLNQSKQVRITILQSAEVGRKLLLSCYTGALE 87

                        90       100
                ....*....|....*....|....*....
gi 45269145 147 MGEKCVLHVMNGAVMYQIDSVVRACSDFL 175
Cdd:cd18197  88 VKKKELLKYLTAASYLQMVHIVEKCTEAL 116
Kelch_6 pfam13964
Kelch motif;
420-460 1.03e-04

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 40.01  E-value: 1.03e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 45269145   420 VIDGHIYAVGG-SHGCIHHNSVERYEPERDEWHLVAPMLTRR 460
Cdd:pfam13964   9 SVGGYIYVFGGyTNASPALNKLEVYNPLTKSWEELPPLPTPR 50
BTB_POZ_Rank-5 cd18303
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 73-185 1.05e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349612 [Multi-domain]  Cd Length: 120  Bit Score: 42.31  E-value: 1.05e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  73 SQQLCDVTLQVKYQdapaaQFMAHKVVLASSSPVFKamFTNGLREQGMEvvsIEGIHPKVMERLIEFAYT--ASISMGEK 150
Cdd:cd18303  15 KELYSDITIKLADK-----SIPAHKFVLAARSEKWS--NENLASTNELD---LSDISYEVVLALLRWLYTdeLDLTLDDE 84

                        90       100       110
                ....*....|....*....|....*....|....*
gi 45269145 151 CVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAI 185
Cdd:cd18303  85 FLLELMKAAKRFQLTDLVERCERALMSSVNVDNCI 119
BTB_POZ_BTBD11 cd18351
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 73-185 1.32e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 11 (BTBD11); BTBD11, also called ankyrin repeat and BTB/POZ domain-containing protein BTBD11, is a BTB-domain-containing protein. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349660 [Multi-domain]  Cd Length: 131  Bit Score: 42.27  E-value: 1.32e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  73 SQQLCDVTLQVKyqdapAAQFMAHKVVLASSSPVFKAMFTNGLREQGmEVVSIEGIHPKVMERLIEFAY---TASISMGE 149
Cdd:cd18351  21 NKEMSDVTFLVE-----GRPFYAHKVLLFTASPRFKALLSNKPSAEN-TCIEISYVKYHIFQLVMQYLYcggTESLLIKN 94

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 45269145 150 KCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAI 185
Cdd:cd18351  95 NEIMELLSAAKFFQLEALQRHCEIICAKSINTENCV 130
BTB_POZ_ZBTB29_HIC1 cd18333
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 59-171 1.37e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1); Hic-1, also called zinc finger and BTB domain-containing protein 29 (ZBTB29), is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. It may act as a tumor suppressor, and is involved in regulatory loops modulating P53-dependent and E2F1-dependent cell survival, growth control, and stress responses. It also regulates intestinal immunity and homeostasis. Hic-1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349642 [Multi-domain]  Cd Length: 121  Bit Score: 41.81  E-value: 1.37e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  59 HTKQAFGIMNELRLSQQLCDVTLQVKyqdapAAQFMAHKVVLASSSPVFKAMFT-NGLREQGMEVVSiegihPKVMERLI 137
Cdd:cd18333   4 HSRQLLLQLNTQRTKGFLCDVIIVVQ-----NALFRAHKNILAASSVYLKSLVVhDNLINLDHEMVS-----PGIFRLIL 73

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 45269145 138 EFAYTASISMG----EKCVLHVMNGAVMYQIDSVVRAC 171
Cdd:cd18333  74 DYIYTGRLSEGdpgsEQNLGAVLAAASYLQIPDLVALC 111
BTB1_POZ_KLHL33 cd18262
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 59-159 1.77e-04

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349571 [Multi-domain]  Cd Length: 101  Bit Score: 41.04  E-value: 1.77e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  59 HTKQAFGIMNELRLSQQLCDVTLQVKYQdapaaQFMAHKVVLASSSPVFKAMFTNglREQGMEVVSIEgIHPKVMERLIE 138
Cdd:cd18262   1 HPSQFFGEAQRLREQRLLLDETVSVGGR-----SYGVHSVILAAVSSLFRERLLG--SNGPLPPLSLE-VTPVGWEAVLT 72

                        90       100
                ....*....|....*....|.
gi 45269145 139 FAYTASISMGEKCVLHVMNGA 159
Cdd:cd18262  73 FAYTGVLGRNPATVGDILVAA 93
BTB_POZ_BTBD18 cd18293
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 62-173 2.09e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349602 [Multi-domain]  Cd Length: 120  Bit Score: 41.31  E-value: 2.09e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  62 QAFGIMNELRLSQQLCDVTLQVKYQDAPaaqfmAHKVVLASSSPVFKAMFTNGLREQGMEVV-SIEGIHPKVMERLIEFA 140
Cdd:cd18293   1 TAFLQLHRQQNSGVFCDVLLQAEGESVP-----AHCCVLSACSPYLTERLSSEPPPAGQKVVlELQGLKAHTLLKLVDFL 75

                        90       100       110
                ....*....|....*....|....*....|...
gi 45269145 141 YTASISMGEKCVLHVMNGAVMYQIDSVVRACSD 173
Cdd:cd18293  76 YTSELEVSSEEAQDVLAAARRLQISELESLCLE 108
BACK_KLHL9_13 cd18449
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 ...
 183-272 4.23e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 and KLHL13 (also termed BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.


Pssm-ID: 350524 [Multi-domain]  Cd Length: 95  Bit Score: 39.71  E-value: 4.23e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145 183 NAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDcEQRRF 262
Cdd:cd18449   5 NCVEIGRIANTYHLTEVDKYVNDFILKNFPALLSTGDFVKLPFERLAFVLSSNSLKGCTELELFKAACRWLRHE-DDRMQ 83

                        90
                ....*....|
gi 45269145 263 YVQALLRAVR 272
Cdd:cd18449  84 FAAKLMENIR 93
Kelch_2 pfam07646
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 361-409 7.37e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 462220 [Multi-domain]  Cd Length: 47  Bit Score: 37.70  E-value: 7.37e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 45269145   361 PRSGLAGCVVGGLLYAVGGRNNSPDgnTDSSALDCYNPMTNQWSPCAPM 409
Cdd:pfam07646   1 PRYPHASSVPGGKLYVVGGSDGLGD--LSSSDVLVYDPETNVWTEVPRL 47
Kelch_3 pfam13415
Galactose oxidase, central domain;
469-515 8.56e-04

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 37.65  E-value: 8.56e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 45269145   469 NRLLYAVGG--FDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVL 515
Cdd:pfam13415   1 GDKLYIFGGlgFDGQTRLNDLYVYDLDTNTWTQIGDLPPPRSGHSATYI 49
Kelch_3 pfam13415
Galactose oxidase, central domain;
371-413 1.16e-03

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 37.27  E-value: 1.16e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 45269145   371 GGLLYAVGGRNnsPDGNTDSSALDCYNPMTNQWSPCAPMSVPR 413
Cdd:pfam13415   1 GDKLYIFGGLG--FDGQTRLNDLYVYDLDTNTWTQIGDLPPPR 41
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 324-359 1.38e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 36.82  E-value: 1.38e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 45269145   324 VGRLIYTAGGY-FRQSLSYLEAYNPSDGTWLRLADLQ 359
Cdd:pfam01344  10 VGGKIYVIGGFdGNQSLNSVEVYDPETNTWSKLPSMP 46
Kelch_2 pfam07646
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 507-550 1.48e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 462220 [Multi-domain]  Cd Length: 47  Bit Score: 36.93  E-value: 1.48e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 45269145   507 RSGAGVCVLHNCIYAAGGYDGQDQL--NSVERYDVETETWTFVAPM 550
Cdd:pfam07646   2 RYPHASSVPGGKLYVVGGSDGLGDLssSDVLVYDPETNVWTEVPRL 47
BTB2_POZ_LZTR1 cd18309
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 77-147 1.93e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349618 [Multi-domain]  Cd Length: 126  Bit Score: 38.52  E-value: 1.93e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 45269145  77 CDVTLQVKYQDAPAaqfmaHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHP--KVMERLIEFAYTASISM 147
Cdd:cd18309  21 CDITLLLDGHPIPA-----HKAILAARCSYFEAMFRSFMPEDNTVNISIGEMVPsrQAFDSLLRYIYYGDVTM 88
BACK_BTBD9 cd14822
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); ...
 198-272 2.06e-03

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation.


Pssm-ID: 350518 [Multi-domain]  Cd Length: 101  Bit Score: 37.98  E-value: 2.06e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 45269145 198 ELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLnvrC--ESEVFHACINWVKYDcEQRRFYVQALLRAVR 272
Cdd:cd14822  20 DLCQTCCQFMDRNAQEVLSSEGFLTLSKSALKELLSRDSF---CapEVDIFNAVRRWCEHN-PDSKEDAKEILEAVR 92
BTB_POZ_GCL cd18305
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 96-177 2.15e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; GCL proteins are nuclear envelope proteins highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in embryos. Both, human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 2 (GMCL2), also called germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L), may function in spermatogenesis. They may also be substrate-specific adaptors of E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. They contain BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349614 [Multi-domain]  Cd Length: 115  Bit Score: 38.42  E-value: 2.15e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  96 HKVVLaSSSPVFKAMFTNGLREQGMEVVSIEGIHPKV-MERL-IEFA--YTASISMGEKCVLHVMNGAVMYQIDSVVRAC 171
Cdd:cd18305  30 HKIYL-CQSGYFASMFSGSWKESKETVINLEIPDDNItVEALnVVFGslYRDEIEIKPSRVVSILAAATLLQLDGLIQQC 108


                ....*.
gi 45269145 172 SDFLVQ 177
Cdd:cd18305 109 SEVMKE 114
PRK14131 PRK14131
N-acetylneuraminate epimerase;
507-611 2.24e-03

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 40.77  E-value: 2.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  507 RSGAGVCVLHNCIYAAGGY-----DGQDQL-NSVERYDVETETWTFV---APMKHRRSAlGITVHQGRIYVLGGYDGHTF 577
Cdd:PRK14131  75 REQAVAAFIDGKLYVFGGIgktnsEGSPQVfDDVYKYDPKTNSWQKLdtrSPVGLAGHV-AVSLHNGKAYITGGVNKNIF 153

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 45269145  578 -----------LDSVE-----------------------CYDPDTDTWSEVTRMT-SGRSgvGVAVTME 611
Cdd:PRK14131 154 dgyfedlaaagKDKTPkdkindayfdkkpedyffnkevlSYDPSTNQWKNAGESPfLGTA--GSAVVIK 220
PRK14131 PRK14131
N-acetylneuraminate epimerase;
323-431 2.26e-03

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 40.77  E-value: 2.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  323 KVGRLIYTAGGYFRQSLSYLEAYNPSDGtWLRLADLQ-VPRSGLAGCVVGGLLYAVGGRNNSPDgNTDSSALD---CYNP 398
Cdd:PRK14131  36 IDNNTVYVGLGSAGTSWYKLDLNAPSKG-WTKIAAFPgGPREQAVAAFIDGKLYVFGGIGKTNS-EGSPQVFDdvyKYDP 113

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 45269145  399 MTNQWSPCAPMSvPRNRIG-VGVI--DGHIYAVGGS 431
Cdd:PRK14131 114 KTNSWQKLDTRS-PVGLAGhVAVSlhNGKAYITGGV 148
BTB_POZ_ZBTB29-like cd18216
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 59-172 2.49e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349525 [Multi-domain]  Cd Length: 118  Bit Score: 38.28  E-value: 2.49e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  59 HTKQAFGIMNELRLSQQLCDVTLQVKyqdapAAQFMAHKVVLASSSPVFKAMFTNglreQGMEVVSIEGIHPKVMERLIE 138
Cdd:cd18216   3 HATQLLLQLNNQRTKGFLCDVIIVVE-----NSLFRAHKNVLAASSGYFKSLVLH----DNLIHLDQDMVSPTVFQQILD 73

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 45269145 139 FAYTASISMGEKCVLH---VMNGAVMYQIDSVVRACS 172
Cdd:cd18216  74 FIYTGKLLDSLFEEPNlseVLAAANYLQLPDLAALCR 110
BTB_POZ_KLHL42 cd18319
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 100-149 3.89e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also called Cullin-3-binding protein 9 (Ctb9) or Kelch domain-containing protein 5, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of katanin (KATNA1). KLHL42 is involved in microtubule dynamics throughout mitosis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349628 [Multi-domain]  Cd Length: 93  Bit Score: 37.16  E-value: 3.89e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 45269145 100 LASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGE 149
Cdd:cd18319  20 LIEQSDYFRALYRSGMRESGEEVVQLRGLSAPGLELVLDFINTSKVHESQ 69
Kelch_6 pfam13964
Kelch motif;
324-362 7.58e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 35.00  E-value: 7.58e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 45269145   324 VGRLIYTAGGYFRQS--LSYLEAYNPSDGTWLRLADLQVPR 362
Cdd:pfam13964  10 VGGYIYVFGGYTNASpaLNKLEVYNPLTKSWEELPPLPTPR 50
BTB2_POZ_IBtk cd18302
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 76-146 7.95e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349611 [Multi-domain]  Cd Length: 113  Bit Score: 36.57  E-value: 7.95e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 45269145  76 LCDVTLQVKyqdaPAAQFMAHKVVLASSSPVFKAMFTNGLREqGMEVVSIE-GIHPKVMERLIEFAYTASIS 146
Cdd:cd18302   5 LYDVTIVSE----DGKEFPCHKCVLVARLEYFHSMLSSSWIE-ASSCSALTmPIPSDILEIILDYLYTDEAS 71
BTB2_POZ_RHOBTB3 cd18360
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 76-179 8.79e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3); RhoBTB3 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB3 is a Golgi-associated Rho-related ATPase that regulates the S/G2 transition of the cell cycle by targeting cyclin E for ubiquitylation. It is involved in vesicle trafficking and in targeting proteins for degradation in the proteasome. It binds directly to Rab9 GTPase and functions with Rab9 in protein transport from endosomes to the trans Golgi network. It also promotes proteasomal degradation of Hypoxia-inducible factor alpha (HIFalpha) through facilitating hydroxylation and suppresses the Warburg effect. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349669 [Multi-domain]  Cd Length: 110  Bit Score: 36.37  E-value: 8.79e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  76 LCDVTLQVKYQDAPAaqfmaHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEkcVLHV 155
Cdd:cd18360  10 LADVVFKIQGTTVPA-----HRAVLVARCEVMAAMFNGNYAEAKSFLVPIYGVSKDTFLSFLEYLYTDSCCPAS--ILQA 82

                        90       100
                ....*....|....*....|....*..
gi 45269145 156 MN---GAVMYQIDSVVRACSDFLVQQL 179
Cdd:cd18360  83 MAlliCAEMYQVSRLQHICELYIITQL 109
BTB_POZ_ZBTB42 cd18956
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 71-182 9.21e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 42 (ZBTB42); ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. It is enriched in skeletal muscles, especially at the neuromuscular junction. A ZBTB42 mutation has been identified to define a novel lethal congenital contracture syndrome (LCCS6), a lethal autosomal recessive form of arthrogryposis multiplex congenita (AMC). ZBTB42 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349737 [Multi-domain]  Cd Length: 129  Bit Score: 36.71  E-value: 9.21e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269145  71 RLSQQ-----LCDVTLQVKyqdapAAQFMAHKVVLASSSpVFKAMFTNGLREQGMEVVSIEG--IHPKVMERLIEFAYTA 143
Cdd:cd18956  13 RLRQQrelgfLCDCTVLVG-----DARFPAHRAVLAACS-VYFHLFYRDRPAGGRDTVRLNGdiVTAPAFGRLLDFMYEG 86

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 45269145 144 SISMGEKCVLHVMNGAVMYQIDSVVRACSDFLvQQLDPS 182
Cdd:cd18956  87 RLDLRSLPVEDVLAAASYLHMYDIVKVCKGRL-REKDPA 124
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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