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Conserved domains on  [gi|41152371|ref|NP_956259|]
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retinol binding protein 4, like precursor [Danio rerio]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
lipocalin_RBP_like cd00743
retinol-binding protein 4 and similar proteins; Retinol-Binding Protein 4 (RBP4) is a plasma ...
 24-196 3.04e-117

retinol-binding protein 4 and similar proteins; Retinol-Binding Protein 4 (RBP4) is a plasma protein that transports retinol (vitamin A) from the liver stores to the peripheral tissues. The RBP4-retinol complex interacts with transthyretin (TTR - transports thyroxine and retinol) which protects it from renal excretion. In addition to retinol, other endogenous and synthetic retinoids bind RBP4, including all-trans and 13-cis retinoic acid, retinyl acetate, N-(ethyl)retinamide, and fenretinide. This group also includes purpurin, a retinol-specific protein that plays a role in neural retina cell adhesion during development of the chicken retina; it also binds retinol and may participate in retinol transporter in the retina. This group belongs to the lipocalin/cytosolic fatty-acid binding protein family which have a large beta-barrel ligand-binding cavity. Lipocalins are mainly low molecular weight extracellular proteins that bind principally small hydrophobic ligands, and form covalent or non-covalent complexes with soluble macromolecules, as well as membrane bound-receptors. They participate in processes such as ligand transport, modulation of cell growth and metabolism, regulation of immune response, smell reception, tissue development and animal behavior. Cytosolic fatty-acid binding proteins, also bind hydrophobic ligands in a non-covalent, reversible manner, and have been implicated in intracellular uptake, transport and storage of hydrophobic ligands, regulation of lipid metabolism and sequestration of excess toxic fatty acids, as well as in signaling, gene expression, inflammation, cell growth and proliferation, and cancer development.


:

Pssm-ID: 381184  Cd Length: 171  Bit Score: 329.79  E-value: 3.04e-117
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152371  24 CAVESFTVKDDFDPKRYAGKWYAQQKKDPEGLFLQDNISAEYTIDDDGTMTASSKGRVTLFGFWVVCADMAAQYSVPDpt 103
Cdd:cd00743   1 CRVSSFRVKENFDKARYAGTWYAMAKKDPEGLFLQDNIVAEFSVDENGTMTATAKGRVRLLNNWDVCADMVGTFTDTE-- 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152371 104 TPAKMFMNYQGLASYLSSGGDNYWVIDTDYDNYAITYACRTLKDDGSCDDGYSLVFSRNPRGLPPAIQRLVRQKQDEICM 183
Cdd:cd00743  79 DPAKFKMKYWGVASYLQKGNDDHWVIDTDYDTYAITYSCRLLNLDGTCADSYSFVFSRDPNGLPPEVQKIVRQRQEELCL 158

                       170
                ....*....|...
gi 41152371 184 AGQFQPVLQSGAC 196
Cdd:cd00743 159 ARQYRLVVHNGYC 171
 
Name Accession Description Interval E-value
lipocalin_RBP_like cd00743
retinol-binding protein 4 and similar proteins; Retinol-Binding Protein 4 (RBP4) is a plasma ...
 24-196 3.04e-117

retinol-binding protein 4 and similar proteins; Retinol-Binding Protein 4 (RBP4) is a plasma protein that transports retinol (vitamin A) from the liver stores to the peripheral tissues. The RBP4-retinol complex interacts with transthyretin (TTR - transports thyroxine and retinol) which protects it from renal excretion. In addition to retinol, other endogenous and synthetic retinoids bind RBP4, including all-trans and 13-cis retinoic acid, retinyl acetate, N-(ethyl)retinamide, and fenretinide. This group also includes purpurin, a retinol-specific protein that plays a role in neural retina cell adhesion during development of the chicken retina; it also binds retinol and may participate in retinol transporter in the retina. This group belongs to the lipocalin/cytosolic fatty-acid binding protein family which have a large beta-barrel ligand-binding cavity. Lipocalins are mainly low molecular weight extracellular proteins that bind principally small hydrophobic ligands, and form covalent or non-covalent complexes with soluble macromolecules, as well as membrane bound-receptors. They participate in processes such as ligand transport, modulation of cell growth and metabolism, regulation of immune response, smell reception, tissue development and animal behavior. Cytosolic fatty-acid binding proteins, also bind hydrophobic ligands in a non-covalent, reversible manner, and have been implicated in intracellular uptake, transport and storage of hydrophobic ligands, regulation of lipid metabolism and sequestration of excess toxic fatty acids, as well as in signaling, gene expression, inflammation, cell growth and proliferation, and cancer development.


Pssm-ID: 381184  Cd Length: 171  Bit Score: 329.79  E-value: 3.04e-117
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152371  24 CAVESFTVKDDFDPKRYAGKWYAQQKKDPEGLFLQDNISAEYTIDDDGTMTASSKGRVTLFGFWVVCADMAAQYSVPDpt 103
Cdd:cd00743   1 CRVSSFRVKENFDKARYAGTWYAMAKKDPEGLFLQDNIVAEFSVDENGTMTATAKGRVRLLNNWDVCADMVGTFTDTE-- 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152371 104 TPAKMFMNYQGLASYLSSGGDNYWVIDTDYDNYAITYACRTLKDDGSCDDGYSLVFSRNPRGLPPAIQRLVRQKQDEICM 183
Cdd:cd00743  79 DPAKFKMKYWGVASYLQKGNDDHWVIDTDYDTYAITYSCRLLNLDGTCADSYSFVFSRDPNGLPPEVQKIVRQRQEELCL 158

                       170
                ....*....|...
gi 41152371 184 AGQFQPVLQSGAC 196
Cdd:cd00743 159 ARQYRLVVHNGYC 171
Lipocalin pfam00061
Lipocalin / cytosolic fatty-acid binding protein family; Lipocalins are transporters for small ...
 41-175 2.94e-10

Lipocalin / cytosolic fatty-acid binding protein family; Lipocalins are transporters for small hydrophobic molecules, such as lipids, steroid hormones, bilins, and retinoids. The family also encompasses the enzyme prostaglandin D synthase (EC:5.3.99.2). Alignment subsumes both the lipocalin and fatty acid binding protein signatures from PROSITE. This is supported on structural and functional grounds. The structure is an eight-stranded beta barrel.


Pssm-ID: 395015  Cd Length: 143  Bit Score: 55.91  E-value: 2.94e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152371    41 AGKWYAQQKKD----PEGLFLQDNISAEYTIDDDGTMTASSkgrVTLFGFWvvCADMAAQYSVPDptTPAKMFMNYQGla 116
Cdd:pfam00061   1 SGKWYLIASANfnelEEEMKALGVGFATIKVLENGNLPVTE---ITKEGGK--CKTVSVTFKKTE--EPGKLGVEFDE-- 71

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 41152371   117 sylSSGGDNYWVIDTDYDNYAITYACrtlKDDGSCDDGYSLVFSRNPRGLPPAIQRLVR 175
Cdd:pfam00061  72 ---YAGGRKVKVLTTDYDNYLIFYQK---GDKDGKTTIVRELYGRDPELSPELLEKFKK 124
Blc COG3040
Bacterial lipocalin Blc [Cell wall/membrane/envelope biogenesis];
1-174 3.54e-09

Bacterial lipocalin Blc [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442274  Cd Length: 178  Bit Score: 53.70  E-value: 3.54e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152371   1 MGFYKFALLVVFLsyierCFSASCAV---ESFTVKDDFDPKRYAGKWYAQQKKDP---EGLflqDNISAEYTIDDDGTMT 74
Cdd:COG3040   1 MKRLRLLLALAAA-----LLLAGCASappPPVTPVPPVDLDRYLGTWYEIARLPHrfeRGC---VNVTAEYSLREDGTIK 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152371  75 ASSKGRVTLFGFWVVcadMAAQYSVPDPTTPAKMFMNYQGLASYlssggdNYWVI--DTDYDnYAITyacrtlkddGSCD 152
Cdd:COG3040  73 VINRGRKGFDGEWKE---AEGKARVVDDPTNAKLKVSFFGPFYG------DYWILalDPDYQ-YALV---------GGPD 133

                       170       180
                ....*....|....*....|...
gi 41152371 153 DGYSLVFSRNPRgLPPAI-QRLV 174
Cdd:COG3040 134 RDYLWILSRTPT-LPDAVyQELL 155
PLN02372 PLN02372
violaxanthin de-epoxidase
 33-170 1.40e-03

violaxanthin de-epoxidase


Pssm-ID: 215212 [Multi-domain]  Cd Length: 455  Bit Score: 38.67  E-value: 1.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152371   33 DDFDPKRYAGKWY--AQQKKDPEGLFLQDNisaEYTIDDDGTMTASSKGRV-TLFGFWVVCADMaaQYSVPDPTTPAKM- 108
Cdd:PLN02372 199 QNFDTADFNGRWYitSGLNKTFDTFDCQLH---EFTAEDPDKLVGNLNWRInTPDGGFFTRSAV--QRFVQDPNQPGILy 273

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 41152371  109 -----FMNYQglasylssggDNYWVIDTDYDNYAITYACRTLKDDGSCDDGY--SLVFSRNPRgLPPAI 170
Cdd:PLN02372 274 nhdneYLHYQ----------DDWYILSSKIENKPDDYVFVYYRGRNDAWDGYggAVVYTRSST-LPESI 331
 
Name Accession Description Interval E-value
lipocalin_RBP_like cd00743
retinol-binding protein 4 and similar proteins; Retinol-Binding Protein 4 (RBP4) is a plasma ...
 24-196 3.04e-117

retinol-binding protein 4 and similar proteins; Retinol-Binding Protein 4 (RBP4) is a plasma protein that transports retinol (vitamin A) from the liver stores to the peripheral tissues. The RBP4-retinol complex interacts with transthyretin (TTR - transports thyroxine and retinol) which protects it from renal excretion. In addition to retinol, other endogenous and synthetic retinoids bind RBP4, including all-trans and 13-cis retinoic acid, retinyl acetate, N-(ethyl)retinamide, and fenretinide. This group also includes purpurin, a retinol-specific protein that plays a role in neural retina cell adhesion during development of the chicken retina; it also binds retinol and may participate in retinol transporter in the retina. This group belongs to the lipocalin/cytosolic fatty-acid binding protein family which have a large beta-barrel ligand-binding cavity. Lipocalins are mainly low molecular weight extracellular proteins that bind principally small hydrophobic ligands, and form covalent or non-covalent complexes with soluble macromolecules, as well as membrane bound-receptors. They participate in processes such as ligand transport, modulation of cell growth and metabolism, regulation of immune response, smell reception, tissue development and animal behavior. Cytosolic fatty-acid binding proteins, also bind hydrophobic ligands in a non-covalent, reversible manner, and have been implicated in intracellular uptake, transport and storage of hydrophobic ligands, regulation of lipid metabolism and sequestration of excess toxic fatty acids, as well as in signaling, gene expression, inflammation, cell growth and proliferation, and cancer development.


Pssm-ID: 381184  Cd Length: 171  Bit Score: 329.79  E-value: 3.04e-117
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152371  24 CAVESFTVKDDFDPKRYAGKWYAQQKKDPEGLFLQDNISAEYTIDDDGTMTASSKGRVTLFGFWVVCADMAAQYSVPDpt 103
Cdd:cd00743   1 CRVSSFRVKENFDKARYAGTWYAMAKKDPEGLFLQDNIVAEFSVDENGTMTATAKGRVRLLNNWDVCADMVGTFTDTE-- 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152371 104 TPAKMFMNYQGLASYLSSGGDNYWVIDTDYDNYAITYACRTLKDDGSCDDGYSLVFSRNPRGLPPAIQRLVRQKQDEICM 183
Cdd:cd00743  79 DPAKFKMKYWGVASYLQKGNDDHWVIDTDYDTYAITYSCRLLNLDGTCADSYSFVFSRDPNGLPPEVQKIVRQRQEELCL 158

                       170
                ....*....|...
gi 41152371 184 AGQFQPVLQSGAC 196
Cdd:cd00743 159 ARQYRLVVHNGYC 171
lipocalin_apoD-like cd19437
apolipoprotein D and similar proteins; Human apolipoprotein D (ApoD) is a small glycoprotein ...
 29-142 1.01e-18

apolipoprotein D and similar proteins; Human apolipoprotein D (ApoD) is a small glycoprotein associated with high density lipoproteins (HDL) in plasma. It appears promiscuous since it can bind hydrophobic ligands belonging to different lipid groups, with different shapes and biochemical properties; however, it exhibits specificity between very similar lipidic species. Some ligands, such as progesterone and arachidonic acid, bind to the ligand-binding pocket with high affinity, while others may interact with ApoD via its region of surface hydrophobicity. This hydrophobic surface cluster may facilitate its association with HDL particles and facilitate its insertion into cellular lipid membranes. Drosophila NLaz and Schistocerca Laz belong to this group, and share functional properties with human ApoD, including regulation of lifespan, lipid and carbohydrate metabolism control, and protection against oxidative stress or starvation. This group also includes Sandercyanin, a blue protein secreted in the skin mucus of blue forms of walleye, Sander vitreus. Walleye is an important golden yellow commercial and sport fish; the findings of blue walleye are recent. This group belongs to the lipocalin/cytosolic fatty-acid binding protein family which have a large beta-barrel ligand-binding cavity. Lipocalins are mainly low molecular weight extracellular proteins that bind principally small hydrophobic ligands, and form covalent or non-covalent complexes with soluble macromolecules, as well as membrane bound-receptors. They participate in processes such as ligand transport, modulation of cell growth and metabolism, regulation of immune response, smell reception, tissue development and animal behavior. Cytosolic fatty-acid binding proteins, also bind hydrophobic ligands in a non-covalent, reversible manner, and have been implicated in intracellular uptake, transport and storage of hydrophobic ligands, regulation of lipid metabolism and sequestration of excess toxic fatty acids, as well as in signaling, gene expression, inflammation, cell growth and proliferation, and cancer development.


Pssm-ID: 381212 [Multi-domain]  Cd Length: 160  Bit Score: 78.83  E-value: 1.01e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152371  29 FTVKDDFDPKRYAGKWYAQQKKDpegLFLQDN---ISAEYTIDDDGTMTASSKGRVTLFG-FWVVcadmAAQYSVPDPTT 104
Cdd:cd19437   7 VPVQEDFDVDKYLGRWYEIERYP---APFEKGgdcVTANYSLNDDGTVRVVNSGINLTDGsINTI----EGSARCPDPNE 79

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 41152371 105 PAKMFMNYQGLASYlssggDNYWVIDTDYDNYAITYAC 142
Cdd:cd19437  80 PAKLGVSFPGFPPA-----GPYWVLDTDYDNYAIVYSC 112
lipocalin_FABP cd00301
lipocalin/cytosolic fatty acid-binding protein family; Lipocalins are diverse, mainly low ...
 39-161 4.83e-13

lipocalin/cytosolic fatty acid-binding protein family; Lipocalins are diverse, mainly low molecular weight extracellular proteins that bind principally small hydrophobic ligands, and form covalent or non-covalent complexes with soluble macromolecules as well as membrane bound-receptors. They have a large beta-barrel ligand-binding cavity. Members include retinol-binding protein, retinoic acid-binding protein, complement protein C8 gamma, Can f 2, apolipoprotein D, extracellular fatty acid-binding protein, beta-lactoglobulin, oderant-binding protein, and bacterial lipocalin Blc. Lipocalins are involved in many important processes such as ligand transport, modulation of cell growth and metabolism, regulation of immune response, smell reception, tissue development and animal behavior. Cytosolic fatty acid-binding proteins also bind hydrophobic ligands in a non-covalent, reversible manner, and are involved in protection and shuttling of fatty acids within the cell, and in acquisition and removal of fatty acids from intracellular sites.


Pssm-ID: 381182  Cd Length: 109  Bit Score: 62.56  E-value: 4.83e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152371  39 RYAGKWYAQQK-KDPEGLFLQDNISAEYTIDDDGTMTASSKGRVTlfgfwVVCADMAAQYSVPDptTPAKMFMNYQGLAs 117
Cdd:cd00301   1 KFSGKWYEVASaSNAPEEDEGKCTTAEYTLEGNGNLKVTNSFVRD-----GVCKSITGTLKKTD--GPGKFTVTYPGYT- 72

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 41152371 118 ylssGGDNYWVIDTDYDNYAITYACRTLKDDGScddGYSLVFSR 161
Cdd:cd00301  73 ----GKNELYVLSTDYDNYAIVYSCKNLDGGHT---VVAWLLSR 109
Lipocalin pfam00061
Lipocalin / cytosolic fatty-acid binding protein family; Lipocalins are transporters for small ...
 41-175 2.94e-10

Lipocalin / cytosolic fatty-acid binding protein family; Lipocalins are transporters for small hydrophobic molecules, such as lipids, steroid hormones, bilins, and retinoids. The family also encompasses the enzyme prostaglandin D synthase (EC:5.3.99.2). Alignment subsumes both the lipocalin and fatty acid binding protein signatures from PROSITE. This is supported on structural and functional grounds. The structure is an eight-stranded beta barrel.


Pssm-ID: 395015  Cd Length: 143  Bit Score: 55.91  E-value: 2.94e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152371    41 AGKWYAQQKKD----PEGLFLQDNISAEYTIDDDGTMTASSkgrVTLFGFWvvCADMAAQYSVPDptTPAKMFMNYQGla 116
Cdd:pfam00061   1 SGKWYLIASANfnelEEEMKALGVGFATIKVLENGNLPVTE---ITKEGGK--CKTVSVTFKKTE--EPGKLGVEFDE-- 71

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 41152371   117 sylSSGGDNYWVIDTDYDNYAITYACrtlKDDGSCDDGYSLVFSRNPRGLPPAIQRLVR 175
Cdd:pfam00061  72 ---YAGGRKVKVLTTDYDNYLIFYQK---GDKDGKTTIVRELYGRDPELSPELLEKFKK 124
Blc COG3040
Bacterial lipocalin Blc [Cell wall/membrane/envelope biogenesis];
1-174 3.54e-09

Bacterial lipocalin Blc [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442274  Cd Length: 178  Bit Score: 53.70  E-value: 3.54e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152371   1 MGFYKFALLVVFLsyierCFSASCAV---ESFTVKDDFDPKRYAGKWYAQQKKDP---EGLflqDNISAEYTIDDDGTMT 74
Cdd:COG3040   1 MKRLRLLLALAAA-----LLLAGCASappPPVTPVPPVDLDRYLGTWYEIARLPHrfeRGC---VNVTAEYSLREDGTIK 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152371  75 ASSKGRVTLFGFWVVcadMAAQYSVPDPTTPAKMFMNYQGLASYlssggdNYWVI--DTDYDnYAITyacrtlkddGSCD 152
Cdd:COG3040  73 VINRGRKGFDGEWKE---AEGKARVVDDPTNAKLKVSFFGPFYG------DYWILalDPDYQ-YALV---------GGPD 133

                       170       180
                ....*....|....*....|...
gi 41152371 153 DGYSLVFSRNPRgLPPAI-QRLV 174
Cdd:COG3040 134 RDYLWILSRTPT-LPDAVyQELL 155
lipocalin_crustacyanin cd19436
crustacyanin Type I CRTC and Type II CRTA subunits; Alpha crustacyanin bound with the ...
 24-172 1.64e-08

crustacyanin Type I CRTC and Type II CRTA subunits; Alpha crustacyanin bound with the carotenoid astaxanthisn (AXT) is the predominant cartenoprotein generating the slate-grey/blue color of the lobster carapace. Crustacyanin forms heterodimers (beta-crustacyanin) or complexes of 16 subunits (alpha-crustacyanin) assembled from beta-crustacyanin. Beta-crustacyanin is formed from one type I CRTC lipocalin subunit, and one type II CRTA lipocalin subunit (and two bound astaxanthin molecules). Homarus gammarus (European lobster) crustacyanin has of five distinct subunits evident on 6 M urea-PAGE gels: type I CRTC ( A1, C1, C2) and type II CRTA ( A2, A3). Homarus americanus crustacyanin consists of only two major subunits, namely type I CRTC (H1) and type II CRTA (H2), both of which behave like Ax subunits on a 6 M urea-PAGE gel. This family includes both type I CRTC subunit and type II CRTA subunits and belongs to the lipocalin/cytosolic fatty-acid binding protein family which have a large beta-barrel ligand-binding cavity. Lipocalins are mainly low molecular weight extracellular proteins that bind principally small hydrophobic ligands, and form covalent or non-covalent complexes with soluble macromolecules, as well as membrane bound-receptors. They participate in processes such as ligand transport, modulation of cell growth and metabolism, regulation of immune response, smell reception, tissue development and animal behavior. Cytosolic fatty-acid binding proteins, also bind hydrophobic ligands in a non-covalent, reversible manner, and have been implicated in intracellular uptake, transport and storage of hydrophobic ligands, regulation of lipid metabolism and sequestration of excess toxic fatty acids, as well as in signaling, gene expression, inflammation, cell growth and proliferation, and cancer development.


Pssm-ID: 381211  Cd Length: 169  Bit Score: 51.70  E-value: 1.64e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152371  24 CAveSFTVKDDFDPKRYAGKWYAQQKKDPEGLFLQDNISAEYTIDDdgtmtasskgrvTLFGFWVVCADMAA-------Q 96
Cdd:cd19436  10 CA--SVANQDNFDLRRYAGRWYQTHLINNPYQPVTRCVHSNYSYSG------------SDYGFKVTSAGFNPdnnylkrN 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152371  97 YSVpdptTPAKMFMNYQGLASYLSSGGDNYWVIDTDYDNYAITYACRTLkddgscdDGY----SLVFSRNPRGLPPAIQR 172
Cdd:cd19436  76 GKV----YPTKEFPAAHMLIDYPSVFAAPYEVIETDYENYSCVYSCIDT-------DGYksefGFVFSRSPQLAGPAVEK 144
lipocalin_Bla_g_4_Per_a_4 cd19440
major allergens Bla g 4 and Per a 4; Inhalant allergens from cockroaches are an important ...
 24-142 2.00e-07

major allergens Bla g 4 and Per a 4; Inhalant allergens from cockroaches are an important cause of asthma. Bla g 4 and Per a 4 are male pheromone transport lipocalins, and both are major allergens. Bla g 4 is produced by Blattella germanica (German cockroach) and has been shown to bind two biogenic amines, tyramine and octopamine which may be its physiological ligands. Per a 4 is produced by Periplaneta americana (American cockroach) and may bind different ligands from Bla g 4 or have different modes for tyramine/octopamine binding. This group belongs to the lipocalin/cytosolic fatty-acid binding protein family which have a large beta-barrel ligand-binding cavity. Lipocalins are mainly low molecular weight extracellular proteins that bind principally small hydrophobic ligands, and form covalent or non-covalent complexes with soluble macromolecules, as well as membrane bound-receptors. They participate in processes such as ligand transport, modulation of cell growth and metabolism, regulation of immune response, smell reception, tissue development and animal behavior. Cytosolic fatty-acid binding proteins, also bind hydrophobic ligands in a non-covalent, reversible manner, and have been implicated in intracellular uptake, transport and storage of hydrophobic ligands, regulation of lipid metabolism and sequestration of excess toxic fatty acids, as well as in signaling, gene expression, inflammation, cell growth and proliferation, and cancer development.


Pssm-ID: 381215  Cd Length: 148  Bit Score: 48.26  E-value: 2.00e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152371  24 CAVESFTVKDdFDPKRYAGKWYAQQKKDPEGLFLQDNISAEYTIDDDGTM-------TASSKGRVTLFGFWVVcadmaaq 96
Cdd:cd19440   1 CQRGDSLFTG-FDYTKYLGVWYEAFRTPNAHEEQYKCWIDRFSLDPEGPIavtsvayDSRGKNRVTLTGTVPV------- 72

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 41152371  97 ysvpdpTTPAKMFMNYQGLASYLSSggdnYWVIDTDYDNYAITYAC 142
Cdd:cd19440  73 ------STGNKFDIDYGDDEAWSSQ----YWVLGTDYETYAILAGC 108
Lipocalin_2 pfam08212
Lipocalin-like domain; Lipocalins are transporters for small hydrophobic molecules, such as ...
 35-177 2.50e-07

Lipocalin-like domain; Lipocalins are transporters for small hydrophobic molecules, such as lipids, steroid hormones, bilins, and retinoids. The structure is an eight-stranded beta barrel.


Pssm-ID: 400495  Cd Length: 143  Bit Score: 48.10  E-value: 2.50e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152371    35 FDPKRYAGKWYAQQKKDpegLFLQDN---ISAEYTIDDDGTMTASSKGRvTLFGFWVVcadMAAQYSVPDPTTPAKMFMN 111
Cdd:pfam08212   1 VDLSRYMGTWYEIARLP---MRFQRGcvdVTATYTLRDDGTIAVTNRCR-TFDGKLKT---AEGVAKVADPGSNAKLKVS 73

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 41152371   112 YQGLASYLSSggdNYWVIDTDYD-NYAITyacrtlkddGSCDDGYSLVFSRNPRgLPPAIQRLVRQK 177
Cdd:pfam08212  74 FLGWFFPVKG---DYWVLYIDPDySWAIV---------GSPSRKYLWILSRTPQ-LSDAQYEQLLEK 127
lipocalin_Blc-like cd19438
bacterial lipocalin Blc, Arabidopsis thaliana temperature-induced lipocalin-1, and similar ...
 33-177 2.87e-06

bacterial lipocalin Blc, Arabidopsis thaliana temperature-induced lipocalin-1, and similar proteins; Escherichia coli bacterial lipocalin (Blc, also known as YjeL) is an outer membrane lipoprotein involved in the storage or transport of lipids necessary for membrane maintenance under stressful conditions. Blc has a binding preference for lysophospholipids. This group includes eukaryotic lipocalins such as Arabidopsis thaliana temperature-induced lipocalin-1 (TIL) which is involved in thermotolerance, oxidative, salt, drought and high light stress tolerance, and is needed for seed longevity by ensuring polyunsaturated lipids integrity. This group belongs to the lipocalin/cytosolic fatty-acid binding protein family which have a large beta-barrel ligand-binding cavity. Lipocalins are mainly low molecular weight extracellular proteins that bind principally small hydrophobic ligands, and form covalent or non-covalent complexes with soluble macromolecules, as well as membrane bound-receptors. They participate in processes such as ligand transport, modulation of cell growth and metabolism, regulation of immune response, smell reception, tissue development and animal behavior. Cytosolic fatty-acid binding proteins, also bind hydrophobic ligands in a non-covalent, reversible manner, and have been implicated in intracellular uptake, transport and storage of hydrophobic ligands, regulation of lipid metabolism and sequestration of excess toxic fatty acids, as well as in signaling, gene expression, inflammation, cell growth and proliferation, and cancer development.


Pssm-ID: 381213  Cd Length: 143  Bit Score: 44.86  E-value: 2.87e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152371  33 DDFDPKRYAGKWYaQQKKDP----EGLFlqdNISAEYTIDDDGTMTASSKGRVTLFGFWVVCADMAaqySVPDPTTPAKM 108
Cdd:cd19438   2 PNVDLDRYMGTWY-EIARLPnrfeKGCV---NVTATYTLNDDGTISVVNRCRDGDEGKWKEAEGKA---RVVDPSDNAKL 74

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 41152371 109 FMNYQGLASYlssgGDnYWVI--DTDYDnYAITyacrtlkddGSCDDGYSLVFSRNPRgLPPAIQRLVRQK 177
Cdd:cd19438  75 KVSFFGPPFY----GD-YWVLalDPDYQ-WALV---------GGPSRDYLWILSRTPQ-LSEETLQRLLEK 129
lipocalin_LTBP1-like cd19423
Triatominae salivary lipocalins such as Rhodnius prolixus LTBP1 and Meccus pallidipennis ...
 30-162 1.77e-05

Triatominae salivary lipocalins such as Rhodnius prolixus LTBP1 and Meccus pallidipennis triabin, and similar proteins; This subfamily includes various insect proteins found in the saliva of Triatominae (kissing bugs), including Rhodnius prolixus leukotriene-binding LTBP1. Rhodnius prolixus, a vector of the pathogen Trypanosoma cruzi, sequesters cysteinyl leukotrienes during feeding to inhibit immediate inflammatory responses; LTBP1 binds leukotrienes C4 (LTC4), D4 (LTD4), and E4 (LTE4). Meccus pallidipennis (syn Triatoma pallidipennis) triabin is a potent and selective thrombin inhibitor. It also includes Triatoma protracta procalin, a major salivary allergen which causes an allergic reaction in humans. It belongs to the lipocalin/cytosolic fatty-acid binding protein family which have a large beta-barrel ligand-binding cavity. Lipocalins are mainly low molecular weight extracellular proteins that bind principally small hydrophobic ligands, and form covalent or non-covalent complexes with soluble macromolecules, as well as membrane bound-receptors. They participate in processes such as ligand transport, modulation of cell growth and metabolism, regulation of immune response, smell reception, tissue development and animal behavior. Cytosolic fatty-acid binding proteins, also bind hydrophobic ligands in a non-covalent, reversible manner, and have been implicated in intracellular uptake, transport and storage of hydrophobic ligands, regulation of lipid metabolism and sequestration of excess toxic fatty acids, as well as in signaling, gene expression, inflammation, cell growth and proliferation, and cancer development.


Pssm-ID: 381198  Cd Length: 132  Bit Score: 42.73  E-value: 1.77e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152371  30 TVKDDFDPKRY-AGKWYAQQKKDPEglflQDNISAEYTI---DDDGTMTASSKGRVTLFGFWVVCA----DMAAQYS--- 98
Cdd:cd19423   7 EPMSNFDSTKFfSGTWYVTHAKNGT----NSTVCRKYKTsknDGKITINYGGYYGGKGKNYEVRCSgtkkSKKGQFSfdc 82

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 41152371  99 -VPDPTtpaKMFMNYQGLASylssggdnywVIDTDYDNYAITYACRTLKDDGScDDGYsLVFSRN 162
Cdd:cd19423  83 kQKNDR---KENTNFQVEFS----------VIDTDYDNYALVYRCVTYGSGKK-KDNY-LVLQRD 132
PLN02372 PLN02372
violaxanthin de-epoxidase
 33-170 1.40e-03

violaxanthin de-epoxidase


Pssm-ID: 215212 [Multi-domain]  Cd Length: 455  Bit Score: 38.67  E-value: 1.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152371   33 DDFDPKRYAGKWY--AQQKKDPEGLFLQDNisaEYTIDDDGTMTASSKGRV-TLFGFWVVCADMaaQYSVPDPTTPAKM- 108
Cdd:PLN02372 199 QNFDTADFNGRWYitSGLNKTFDTFDCQLH---EFTAEDPDKLVGNLNWRInTPDGGFFTRSAV--QRFVQDPNQPGILy 273

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 41152371  109 -----FMNYQglasylssggDNYWVIDTDYDNYAITYACRTLKDDGSCDDGY--SLVFSRNPRgLPPAI 170
Cdd:PLN02372 274 nhdneYLHYQ----------DDWYILSSKIENKPDDYVFVYYRGRNDAWDGYggAVVYTRSST-LPESI 331
Triabin pfam03973
Triabin; Triabin is a serine-protease inhibitor with a calycin fold.
 31-168 4.34e-03

Triabin; Triabin is a serine-protease inhibitor with a calycin fold.


Pssm-ID: 397875  Cd Length: 147  Bit Score: 36.08  E-value: 4.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152371    31 VKDDFDPKRY-AGKWYAQQKKDPEglflQDNISAEYTIDDDGTMTASSK-GRVTLFGFWVVCA-----DMAAQYSVPDPT 103
Cdd:pfam03973  17 AMDDFDLEKFfSGHWYLTHARNVT----HPQVCQKYTTTGNKDGTVTSDiKFNGPYGSEVKCTntkvsGKKGQYSFECEV 92

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 41152371   104 TPAKMFmnyqglASYLSsggdnywVIDTDYDNYAITYACrtLKDDGSCDDGYsLVFSRNPRGLPP 168
Cdd:pfam03973  93 SGGKKF------TAETS-------VIATDYKNYALLYRC--GKTESPIEDNF-LVFQRKKSGTDP 141
lipocalin_VDE cd19420
lipocalin domain of violaxanthin deepoxidase and similar proteins; Plant violaxanthin ...
 34-170 6.14e-03

lipocalin domain of violaxanthin deepoxidase and similar proteins; Plant violaxanthin de-epoxidase (VDE, EC 1.23.5.1) participates in the xanthophyll cycle for controlling the concentration of zeaxanthin in chloroplasts. It catalyzes the conversion of violaxanthin to antheraxanthin and zeaxanthin in strong light, and plays a central role in adjusting photosynthetic activity to changing light conditions. In addition, maize VDE has been shown to interact with sugarcane mosaic virus helper component-proteinase, HC-(SCMV), and to attenuate the RNA silencing suppression activity of the latter. VDE belongs to the lipocalin/cytosolic fatty-acid binding protein family which have a large beta-barrel ligand-binding cavity. Lipocalins are mainly low molecular weight extracellular proteins that bind principally small hydrophobic ligands, and form covalent or non-covalent complexes with soluble macromolecules, as well as membrane bound-receptors. They participate in processes such as ligand transport, modulation of cell growth and metabolism, regulation of immune response, smell reception, tissue development and animal behavior. Cytosolic fatty-acid binding proteins, also bind hydrophobic ligands in a non-covalent, reversible manner, and have been implicated in intracellular uptake, transport and storage of hydrophobic ligands, regulation of lipid metabolism and sequestration of excess toxic fatty acids, as well as in signaling, gene expression, inflammation, cell growth and proliferation, and cancer development.


Pssm-ID: 381195  Cd Length: 177  Bit Score: 35.98  E-value: 6.14e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152371  34 DFDPKRYAGKWY--AQQKKDPEGLFLQDNisaEYTIDDDGTMTASSKGRVTLF--GFWvvcADMAAQYSVPDPTTPAKM- 108
Cdd:cd19420  16 SFDMNDFNGKWYitAGLNPTFDTFDCQLH---FFHVEGDDKLVGKINWRIKTPdgGFF---TRSAVQRFVQDPNQPGILy 89

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 41152371 109 -----FMNYQglasylssggDNYWVIDTDYDNYAITYACRTLKDDGSCDDGY--SLVFSRNPRgLPPAI 170
Cdd:cd19420  90 nhdneYLHYQ----------DDWYILSYKIENKPEDYIFVYYRGRNDAWDGYggAVVYTRSST-LPPSY 147
PRK10477 PRK10477
outer membrane lipoprotein Blc; Provisional
 30-79 6.96e-03

outer membrane lipoprotein Blc; Provisional


Pssm-ID: 182489  Cd Length: 177  Bit Score: 35.84  E-value: 6.96e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 41152371   30 TVKDDFDPKRYAGKWYAQQKKD---PEGLflqDNISAEYTIDDDGTMTASSKG 79
Cdd:PRK10477  29 TVVNNFDAKRYLGTWYEIARFDhrfERGL---EKVTATYSLRDDGGLNVINKG 78
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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