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Conserved domains on  [gi|268370222|ref|NP_932128|]
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uncharacterized protein LOC101604 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204806)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
22-81 2.10e-25

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 98.43  E-value: 2.10e-25
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370222    22 VSFADVAVYFSPEEWRCLRPAQRTLYREVMRETYGLLASLEVGGDKPALICWVEEESEVW 81
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPW 60
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
223-383 4.93e-06

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.92  E-value: 4.93e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370222 223 PHQCPDCGKSFTQRSTLVAHMYT--HTGE--KPFHCP--DCNKSFSRPSSLSSHRAIHRGERPHCCSDCGRAFTHRSGLI 296
Cdd:COG5048  289 PIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLN 368

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370222 297 AHLRVHT-------GEKPYCCAD--CGRCFSQSSGLREHqRVVHSGVTP--FTCTHCGRAFARAAYLQCHMRTHTGEKPY 365
Cdd:COG5048  369 NEPPQSLqqykdlkNDKKSETLSnsCIRNFKRDSNLSLH-IITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                        170
                 ....*....|....*...
gi 268370222 366 SCPDCGRcFRQSSDMAAH 383
Cdd:COG5048  448 LCSILKS-FRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
183-205 9.67e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 9.67e-04
                          10        20
                  ....*....|....*....|...
gi 268370222  183 LVEHLYTHTGEKPFQCPDCDKYF 205
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
383-402 7.61e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 7.61e-03
                          10        20
                  ....*....|....*....|
gi 268370222  383 HRRTHSGERPYPCPQCGRRF 402
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSF 24
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
22-81 2.10e-25

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 98.43  E-value: 2.10e-25
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370222    22 VSFADVAVYFSPEEWRCLRPAQRTLYREVMRETYGLLASLEVGGDKPALICWVEEESEVW 81
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPW 60
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 22-61 5.86e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 82.52  E-value: 5.86e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 268370222   22 VSFADVAVYFSPEEWRCLRPAQRTLYREVMRETYGLLASL 61
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 22-61 5.20e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 77.20  E-value: 5.20e-18
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 268370222  22 VSFADVAVYFSPEEWRCLRPAQRTLYREVMRETYGLLASL 61
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
223-383 4.93e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.92  E-value: 4.93e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370222 223 PHQCPDCGKSFTQRSTLVAHMYT--HTGE--KPFHCP--DCNKSFSRPSSLSSHRAIHRGERPHCCSDCGRAFTHRSGLI 296
Cdd:COG5048  289 PIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLN 368

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370222 297 AHLRVHT-------GEKPYCCAD--CGRCFSQSSGLREHqRVVHSGVTP--FTCTHCGRAFARAAYLQCHMRTHTGEKPY 365
Cdd:COG5048  369 NEPPQSLqqykdlkNDKKSETLSnsCIRNFKRDSNLSLH-IITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                        170
                 ....*....|....*...
gi 268370222 366 SCPDCGRcFRQSSDMAAH 383
Cdd:COG5048  448 LCSILKS-FRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
355-376 5.58e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 5.58e-04
                          10        20
                  ....*....|....*....|..
gi 268370222  355 HMRTHTGEKPYSCPDCGRCFRQ 376
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
183-205 9.67e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 9.67e-04
                          10        20
                  ....*....|....*....|...
gi 268370222  183 LVEHLYTHTGEKPFQCPDCDKYF 205
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
PRK05580 PRK05580
primosome assembly protein PriA; Validated
 170-232 3.35e-03

primosome assembly protein PriA; Validated


Pssm-ID: 235514 [Multi-domain]  Cd Length: 679  Bit Score: 39.75  E-value: 3.35e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 268370222 170 CHVCGKSFahqsklvehlythtgekpfQCPDCDkyfgraSSLSMHRAIHR------GER---PHQCPDCGKS 232
Cdd:PRK05580 384 CRDCGWVA-------------------ECPHCD------ASLTLHRFQRRlrchhcGYQepiPKACPECGST 430
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
112-287 5.26e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.29  E-value: 5.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370222 112 EETKATKKILSPEAGPMEPRPSFASPS--CNLELLFKNSQQGHPTVAVHNPILKA-------DQRHGCHVCGKSFAHQSK 182
Cdd:COG5048  225 SSLPLTTNSQLSPKSLLSQSPSSLSSSdsSSSASESPRSSLPTASSQSSSPNESDsssekgfSLPIKSKQCNISFSRSSP 304

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370222 183 LVEHLYT--HTGE--KPFQCP--DCDKYFGRASSLSMHRAIHRGERPHQC------------------------------ 226
Cdd:COG5048  305 LTRHLRSvnHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEkllnssskfspllnneppqslqqykdlknd 384

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370222 227 -------PDCGKSFTQRSTLVAHMYTHTGEKP--FHCPDCNKSFSRPSSLSSHRAIHRGERPHCCSDCGR 287
Cdd:COG5048  385 kksetlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
zf-H2C2_2 pfam13465
Zinc-finger double domain;
383-402 7.61e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 7.61e-03
                          10        20
                  ....*....|....*....|
gi 268370222  383 HRRTHSGERPYPCPQCGRRF 402
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSF 24
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
22-81 2.10e-25

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 98.43  E-value: 2.10e-25
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370222    22 VSFADVAVYFSPEEWRCLRPAQRTLYREVMRETYGLLASLEVGGDKPALICWVEEESEVW 81
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPW 60
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 22-61 5.86e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 82.52  E-value: 5.86e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 268370222   22 VSFADVAVYFSPEEWRCLRPAQRTLYREVMRETYGLLASL 61
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 22-61 5.20e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 77.20  E-value: 5.20e-18
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 268370222  22 VSFADVAVYFSPEEWRCLRPAQRTLYREVMRETYGLLASL 61
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
223-383 4.93e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.92  E-value: 4.93e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370222 223 PHQCPDCGKSFTQRSTLVAHMYT--HTGE--KPFHCP--DCNKSFSRPSSLSSHRAIHRGERPHCCSDCGRAFTHRSGLI 296
Cdd:COG5048  289 PIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLN 368

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370222 297 AHLRVHT-------GEKPYCCAD--CGRCFSQSSGLREHqRVVHSGVTP--FTCTHCGRAFARAAYLQCHMRTHTGEKPY 365
Cdd:COG5048  369 NEPPQSLqqykdlkNDKKSETLSnsCIRNFKRDSNLSLH-IITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                        170
                 ....*....|....*...
gi 268370222 366 SCPDCGRcFRQSSDMAAH 383
Cdd:COG5048  448 LCSILKS-FRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
194-342 1.75e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.00  E-value: 1.75e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370222 194 KPFQCPDCDKYFGRASSLSMHR--AIHRGE--RPHQCP--DCGKSFTQRSTLVAHMYTHTGEKPFHCPDCN-------KS 260
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEKLLNssskfspLL 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370222 261 FSRPSSLSSHRAIHRGERPHCCSD--CGRAFTHRSGLIAHLRVHTGEKPYCC--ADCGRCFSQSSGLREHQRVVHSGVTP 336
Cdd:COG5048  368 NNEPPQSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAPL 447


                 ....*.
gi 268370222 337 FTCTHC 342
Cdd:COG5048  448 LCSILK 453
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
158-443 3.36e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.76  E-value: 3.36e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370222 158 HNPILKADQRHGCHVCGKSFAHQSKLVEHLYTHTGEKPFQCPD--CDKYFGRASSLSMHRAIHRGERPH----------- 224
Cdd:COG5048   24 LKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDlnskslplsns 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370222 225 ------------------QCPDCGKSFTQRSTLVAHMYTHTGEKPFHCPDCNKSFSRPSSLSSHRAIHRGER-------- 278
Cdd:COG5048  104 kasssslsssssnsndnnLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSlskdpssn 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370222 279 --PHCCSDcgRAFTHRSGLIAHLRVHTGEKPYCCADCGRCFSQSS------GLREHQRVVH----SGVTPFTCTHCG--- 343
Cdd:COG5048  184 lsLLISSN--VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSlplttnSQLSPKSLLSqspsSLSSSDSSSSASesp 261

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370222 344 ------RAFARAAYLQCHMRTHTG-EKPYSCPDCGRCFRQSSDMAAHRRT--HSGE--RPYPCP--QCGRRFPTKSAVTK 410
Cdd:COG5048  262 rsslptASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPysLCGKLFSRNDALKR 341

                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 268370222 411 HQWVH---RPGAK--GHKDKKFSQLSISLDPSQEDPDP 443
Cdd:COG5048  342 HILLHtsiSPAKEklLNSSSKFSPLLNNEPPQSLQQYK 379
zf-H2C2_2 pfam13465
Zinc-finger double domain;
355-376 5.58e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 5.58e-04
                          10        20
                  ....*....|....*....|..
gi 268370222  355 HMRTHTGEKPYSCPDCGRCFRQ 376
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
210-235 9.48e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 9.48e-04
                          10        20
                  ....*....|....*....|....*.
gi 268370222  210 SLSMHRAIHRGERPHQCPDCGKSFTQ 235
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
183-205 9.67e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 9.67e-04
                          10        20
                  ....*....|....*....|...
gi 268370222  183 LVEHLYTHTGEKPFQCPDCDKYF 205
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 224-246 1.13e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.12  E-value: 1.13e-03
                          10        20
                  ....*....|....*....|...
gi 268370222  224 HQCPDCGKSFTQRSTLVAHMYTH 246
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 365-387 3.22e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 3.22e-03
                          10        20
                  ....*....|....*....|...
gi 268370222  365 YSCPDCGRCFRQSSDMAAHRRTH 387
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
PRK05580 PRK05580
primosome assembly protein PriA; Validated
 170-232 3.35e-03

primosome assembly protein PriA; Validated


Pssm-ID: 235514 [Multi-domain]  Cd Length: 679  Bit Score: 39.75  E-value: 3.35e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 268370222 170 CHVCGKSFahqsklvehlythtgekpfQCPDCDkyfgraSSLSMHRAIHR------GER---PHQCPDCGKS 232
Cdd:PRK05580 384 CRDCGWVA-------------------ECPHCD------ASLTLHRFQRRlrchhcGYQepiPKACPECGST 430
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
112-287 5.26e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.29  E-value: 5.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370222 112 EETKATKKILSPEAGPMEPRPSFASPS--CNLELLFKNSQQGHPTVAVHNPILKA-------DQRHGCHVCGKSFAHQSK 182
Cdd:COG5048  225 SSLPLTTNSQLSPKSLLSQSPSSLSSSdsSSSASESPRSSLPTASSQSSSPNESDsssekgfSLPIKSKQCNISFSRSSP 304

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370222 183 LVEHLYT--HTGE--KPFQCP--DCDKYFGRASSLSMHRAIHRGERPHQC------------------------------ 226
Cdd:COG5048  305 LTRHLRSvnHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEkllnssskfspllnneppqslqqykdlknd 384

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268370222 227 -------PDCGKSFTQRSTLVAHMYTHTGEKP--FHCPDCNKSFSRPSSLSSHRAIHRGERPHCCSDCGR 287
Cdd:COG5048  385 kksetlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
zf-H2C2_2 pfam13465
Zinc-finger double domain;
383-402 7.61e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 7.61e-03
                          10        20
                  ....*....|....*....|
gi 268370222  383 HRRTHSGERPYPCPQCGRRF 402
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSF 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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