NCBI Conserved Domain Search

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

322-583

2.48e-52

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

Pssm-ID: 442289 [Multi-domain] Cd Length: 277 Bit Score: 180.35 E-value: 2.48e-52

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238 322 PKADLPSPRKEFSASAIGCKVYVTGGRgSENGVSKDVWVYDTVHEEWSKAAPM-LIARFGHGSAELENCLYVVGGHTSla 400
Cdd:COG3055   5 SLPDLPTPRSEAAAALLDGKVYVAGGL-SGGSASNSFEVYDPATNTWSELAPLpGPPRHHAAAVAQDGKLYVFGGFTG-- 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238 401 gifPASPSVSLKQVEKYDPGDNKWTMVAPMRDGVSNAAVVSAKLKLFVFGGTSIHRDmVSKVQCFDPSENRWTIKAECPQ 480
Cdd:COG3055  82 ---ANPSSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGN-VAWVEVYDPATGTWTQLAPLPT 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238 481 P-WRYTAAAVLGSQIFIMGGDTEYTAasayrfdceTNQWTRIGDMTAKRMSCHAVASGNKLYVVGGYFGTQrcKTLDCYD 559
Cdd:COG3055 158 PrDHLAAAVLPDGKILVIGGRNGSGF---------SNTWTTLAPLPTARAGHAAAVLGGKILVFGGESGFS--DEVEAYD 226

                       250       260
                ....*....|....*....|....
gi 33354238 560 PTSDTWNCITTVPYSLIPTAFVST 583
Cdd:COG3055 227 PATNTWTALGELPTPRHGHAAVLT 250

BACK

pfam07707

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...

149-250

1.66e-38

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).

Pssm-ID: 462237 [Multi-domain] Cd Length: 103 Bit Score: 136.91 E-value: 1.66e-38

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238   149 CLGMMVLSDAHQCRRLYEFSCRMSLVHFETVRQSEDFNSLSRDTLLDLISRDELETEDERVVFEAILQWVKHDLEQRKAH 228
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKH 80

                          90       100
                  ....*....|....*....|..
gi 33354238   229 LPLLLRNVRLALLPSDCLKNAV 250
Cdd:pfam07707  81 LPELLSAVRLPLLSPQYLLNLV 102

BACK

smart00875

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...

149-248

4.15e-34

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.

Pssm-ID: 197943 [Multi-domain] Cd Length: 101 Bit Score: 124.76 E-value: 4.15e-34

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238    149 CLGMMVLSDAHQCRRLYEFSCRMSLVHFETVRQSEDFNSLSRDTLLDLISRDELETEDERVVFEAILQWVKHDLEQRKAH 228
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREH 80

                           90       100
                   ....*....|....*....|
gi 33354238    229 LPLLLRNVRLALLPSDCLKN 248
Cdd:smart00875  81 LPELLEHVRLPLLSPDYLLE 100

BTB

pfam00651

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...

36-144

8.25e-31

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

Pssm-ID: 395526 [Multi-domain] Cd Length: 107 Bit Score: 115.82 E-value: 8.25e-31

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238    36 LNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQDnLHPEVLELLLDFAYSSRIvINEE 115
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDD-VSPEDFEALLEFMYTGKL-ISEE 78

                          90       100
                  ....*....|....*....|....*....
gi 33354238   116 NAESLLEAGDMLQFHDVRDAAAEFLEKNL 144
Cdd:pfam00651  79 NVDDLLAAADKLQIPSLVDKCEEFLIKSL 107

BTB

smart00225

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...

47-144

4.09e-26

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

Pssm-ID: 197585 [Multi-domain] Cd Length: 97 Bit Score: 102.38 E-value: 4.09e-26

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238     47 DVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQDnLHPEVLELLLDFAYSSRIVINEENAESLLEAGDM 126
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDD-VSPEDFRALLNFLYTGKLDLPEENVEELLELADY 79

                           90
                   ....*....|....*...
gi 33354238    127 LQFHDVRDAAAEFLEKNL 144
Cdd:smart00225  80 LQIPGLVELCEEFLLKLL 97

muta_rot_YjhT

TIGR03547

mutatrotase, YjhT family; Members of this protein family contain multiple copies of the ...

325-547

1.85e-05

mutatrotase, YjhT family; Members of this protein family contain multiple copies of the beta-propeller-forming Kelch repeat. All are full-length homologs to YjhT of Escherichia coli, which has been identified as a mutarotase for sialic acid. This protein improves bacterial ability to obtain host sialic acid, and thus serves as a virulence factor. Some bacteria carry what appears to be a cyclically permuted homolog of this protein.

Pssm-ID: 274641 [Multi-domain] Cd Length: 346 Bit Score: 46.93 E-value: 1.85e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238   325 DLPSPRKEFSASAIGCKVYVtgGRGSengVSKDVWVYDT--VHEEWSKAAPML-IARFGHGSAELENCLYVVGGhtslAG 401
Cdd:TIGR03547   3 DLPVGFKNGTGAIIGDKVYV--GLGS---AGTSWYKLDLkkPSKGWQKIADFPgGPRNQAVAAAIDGKLYVFGG----IG 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238   402 IFPASPSVS-LKQVEKYDPGDNKWTMVaPMRDGVSNAAVVSAKL---KLFVFGGT-----------------------SI 454
Cdd:TIGR03547  74 KANSEGSPQvFDDVYRYDPKKNSWQKL-DTRSPVGLLGASGFSLhngQAYFTGGVnknifdgyfadlsaadkdsepkdKL 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238   455 HRDMVSK----------VQCFDPSENRWTIKAECPQPWRYTAAAVL-GSQIFIMGGDTE---YTAAS-AYRFDCETNQWT 519
Cdd:TIGR03547 153 IAAYFSQppedyfwnknVLSYDPSTNQWRNLGENPFLGTAGSAIVHkGNKLLLINGEIKpglRTAEVkQYLFTGGKLEWN 232

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 33354238   520 RIGDMTAKRMSCH-AVA------SGNKLYVVGG-YF 547
Cdd:TIGR03547 233 KLPPLPPPKSSSQeGLAgafagiSNGVLLVAGGaNF 268

Name

Accession

Description

Interval

E-value

BTB_POZ_KLHL25

cd18254

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

24-151

6.83e-95

Pssm-ID: 349563 [Multi-domain] Cd Length: 128 Bit Score: 286.14 E-value: 6.83e-95

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  24 HKASHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQDNLHPEVLELLLD 103
Cdd:cd18254   1 HKPSHPDCVLTHLNTLRKQCMFTDVTLWAGNRSFPCHRAVLAACSRYFEAMFSNGLRESLDSTVNFHDSLHPEVLELLLD 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 33354238 104 FAYSSRIVINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLSPSNCLG 151
Cdd:cd18254  81 FAYSSRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNCLG 128

BTB_POZ_KLHL37_ENC1

cd18267

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

6-152

1.24e-89

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349576 [Multi-domain] Cd Length: 147 Bit Score: 273.40 E-value: 1.24e-89

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238   6 HETRKSRSSTGSMNISVFHKASHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDD 85
Cdd:cd18267   1 HENRKSRASSGSMNIYLFHKSSYADSVLTHLNLLRQQRLFTDVLLHAGNRSFPCHRAVLAACSRYFEAMFSGGLKESQDS 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 33354238  86 TVNFQDNLHPEVLELLLDFAYSSRIVINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLSPSNCLGM 152
Cdd:cd18267  81 EVNFHDSIHPEVLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLHPTNCLGM 147

PHA03098

kelch-like protein; Provisional

39-566

3.09e-59

kelch-like protein; Provisional

Pssm-ID: 222983 [Multi-domain] Cd Length: 534 Bit Score: 206.16 E-value: 3.09e-59

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238   39 LRKHCMFTdVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLREsrdDTVNFQDNLHpeVLELLLDFAYSSRIVINEENAE 118
Cdd:PHA03098   6 LQKFCDES-IIIVNGGGIIKVHKIILSSSSEYFKKMFKNNFKE---NEINLNIDYD--SFNEVIKYIYTGKINITSNNVK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  119 SLLEAGDMLQFHDVRDAAAEFLEKNLSPSNCLGMMVLSDAHQCRRLYEFSCRMSLVHFETVRQSEDFNSLSRDTLLDLIS 198
Cdd:PHA03098  80 DILSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKILS 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  199 RDELETEDERVVFEAILQWVKHDLEQRKAHLPLLLRNVRLALLPSDCLKnavSGEALLMADECTKLILDEAFRC----KT 274
Cdd:PHA03098 160 DDKLNVSSEDVVLEIIIKWLTSKKNNKYKDICLILKVLRITFLSEEGIK---KLKRWKLRIKKKKIVFNKRCIKiiysKK 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  275 KILLNDGVVTSPFARPrkaghtLLILGGQTFMCDKIYQVDHKAKEIIPKADLPSPRKeFSASAIGCKVYVTGGRGSENGV 354
Cdd:PHA03098 237 YNLNKILPRSSTFGSI------IYIHITMSIFTYNYITNYSPLSEINTIIDIHYVYC-FGSVVLNNVIYFIGGMNKNNLS 309

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  355 SKDVWVYDTVHEEWSKAAPMLIARFGHGSAELENCLYVVGGhtslagifpASPSVSLKQVEKYDPGDNKWTMVAPMRDGV 434
Cdd:PHA03098 310 VNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGG---------IYNSISLNTVESWKPGESKWREEPPLIFPR 380

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  435 SNAAVVSAKLKLFVFGGTSIHRDMVSKVQCFDPSENRWTIKAECPQPWRYTAAAVLGSQIFIMGGDTEYTAASAY----R 510
Cdd:PHA03098 381 YNPCVVNVNNLIYVIGGISKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGISYIDNIKVYniveS 460

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 33354238  511 FDCETNQWTRIGDMTAKRMSCHAVASGNKLYVVGGYFGTQRCKTLDCYDPTSDTWN 566
Cdd:PHA03098 461 YNPVTNKWTELSSLNFPRINASLCIFNNKIYVVGGDKYEYYINEIEVYDDKTNTWT 516

BACK_KLHL25_ENC2

cd18514

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also ...

144-242

2.58e-57

Pssm-ID: 350589 [Multi-domain] Cd Length: 99 Bit Score: 187.36 E-value: 2.58e-57

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238 144 LSPSNCLGMMVLSDAHQCRRLYEFSCRMSLVHFETVRQSEDFNSLSRDTLLDLISRDELETEDERVVFEAILQWVKHDLE 223
Cdd:cd18514   1 LHPSNCLGMMLLSDAHQCRRLYELSWRMCLVHFETVRESEDFYSLSKDKLLDLISSDELEIEDEQVVFNAVLQWVKYDLE 80

                        90
                ....*....|....*....
gi 33354238 224 QRKAHLPLLLRNVRLALLP 242
Cdd:cd18514  81 KRKDYLPELLRNVRLALLP 99

NanM

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

322-583

2.48e-52

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

Pssm-ID: 442289 [Multi-domain] Cd Length: 277 Bit Score: 180.35 E-value: 2.48e-52

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238 322 PKADLPSPRKEFSASAIGCKVYVTGGRgSENGVSKDVWVYDTVHEEWSKAAPM-LIARFGHGSAELENCLYVVGGHTSla 400
Cdd:COG3055   5 SLPDLPTPRSEAAAALLDGKVYVAGGL-SGGSASNSFEVYDPATNTWSELAPLpGPPRHHAAAVAQDGKLYVFGGFTG-- 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238 401 gifPASPSVSLKQVEKYDPGDNKWTMVAPMRDGVSNAAVVSAKLKLFVFGGTSIHRDmVSKVQCFDPSENRWTIKAECPQ 480
Cdd:COG3055  82 ---ANPSSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGN-VAWVEVYDPATGTWTQLAPLPT 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238 481 P-WRYTAAAVLGSQIFIMGGDTEYTAasayrfdceTNQWTRIGDMTAKRMSCHAVASGNKLYVVGGYFGTQrcKTLDCYD 559
Cdd:COG3055 158 PrDHLAAAVLPDGKILVIGGRNGSGF---------SNTWTTLAPLPTARAGHAAAVLGGKILVFGGESGFS--DEVEAYD 226

                       250       260
                ....*....|....*....|....
gi 33354238 560 PTSDTWNCITTVPYSLIPTAFVST 583
Cdd:COG3055 227 PATNTWTALGELPTPRHGHAAVLT 250

BACK_KLHL25_like

cd18464

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The ...

146-242

5.55e-52

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The family includes KLHL25 and KLHL37. KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.

Pssm-ID: 350539 [Multi-domain] Cd Length: 98 Bit Score: 173.07 E-value: 5.55e-52

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238 146 PSNCLGMMVLSDAHQCRRLYEFSCRMSLVHFETVRQSEDFNSLSRDTLLDLISRDELETEDERVVFEAILQWVKHDLEQR 225
Cdd:cd18464   2 PSNCLGMLLLSDAHQCQRLYELSWRMCLANFTTLRKTEDFLSLPKDKLLELVSSEELEVEDERLVYEAVIGWIRYDLPRR 81

                        90
                ....*....|....*..
gi 33354238 226 KAHLPLLLRNVRLALLP 242
Cdd:cd18464  82 HEVLPELLRSVRLALLP 98

NanM

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

284-545

5.72e-45

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

Pssm-ID: 442289 [Multi-domain] Cd Length: 277 Bit Score: 160.71 E-value: 5.72e-45

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238 284 TSPFARPRKAGHTLLI------LGGQTF--MCDKIYQVDHKAKEIIPKADLPSPRKEFSASA-IGCKVYVTGGRGSENG- 353
Cdd:COG3055   6 LPDLPTPRSEAAAALLdgkvyvAGGLSGgsASNSFEVYDPATNTWSELAPLPGPPRHHAAAVaQDGKLYVFGGFTGANPs 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238 354 --VSKDVWVYDTVHEEWSKAAPMLIARFGHGSAELENCLYVVGGHTSlagifpaspSVSLKQVEKYDPGDNKWTMVAPM- 430
Cdd:COG3055  86 stPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDD---------GGNVAWVEVYDPATGTWTQLAPLp 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238 431 --RDGVsnAAVVSAKLKLFVFGGTSihrdmvskvqcFDPSENRWTIKAECPQPWRYTAAAVLGSQIFIMGGDTEYTaASA 508
Cdd:COG3055 157 tpRDHL--AAAVLPDGKILVIGGRN-----------GSGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGGESGFS-DEV 222

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 33354238 509 YRFDCETNQWTRIGDMTAKRMSCHAVASGNKLYVVGG 545
Cdd:COG3055 223 EAYDPATNTWTALGELPTPRHGHAAVLTDGKVYVIGG 259

BACK_KLHL37_ENC1

cd18515

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also ...

146-242

3.94e-42

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.

Pssm-ID: 350590 [Multi-domain] Cd Length: 98 Bit Score: 146.66 E-value: 3.94e-42

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238 146 PSNCLGMMVLSDAHQCRRLYEFSCRMSLVHFETVRQSEDFNSLSRDTLLDLISRDELETEDERVVFEAILQWVKHDLEQR 225
Cdd:cd18515   2 PTNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTICKTEDFLQLPKDMVVQLLSSEELETEDERLVYEAAINWVNYDLKKR 81

                        90
                ....*....|....*..
gi 33354238 226 KAHLPLLLRNVRLALLP 242
Cdd:cd18515  82 HCYLSELLQTVRLALLP 98

BTB_POZ_KLHL21

cd18250

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

26-149

5.65e-42

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349559 [Multi-domain] Cd Length: 124 Bit Score: 147.22 E-value: 5.65e-42

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  26 ASHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQDnLHPEVLELLLDFA 105
Cdd:cd18250   2 PAHALHLLRGLSELRAERKFFDVTLCAGGREFPCHRTVLAAASSYFRAMFAGELRESRADRVVLHG-VSAEILGLLLDFS 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 33354238 106 YSSRIVINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLSPSNC 149
Cdd:cd18250  81 YTGRVTVTQDNVEALLRAADLFQFPSVKEACCAYLQQRLDVSNC 124

BTB_POZ_KLHL27_IPP

cd18256

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

26-151

1.10e-38

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349565 [Multi-domain] Cd Length: 125 Bit Score: 138.31 E-value: 1.10e-38

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  26 ASHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQdNLHPEVLELLLDFA 105
Cdd:cd18256   1 DKHASLILAQLNKLRGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALFAGGMSESSKDVVQIH-GVEPDIFHILLDFI 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 33354238 106 YSSRIVINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLSPSNCLG 151
Cdd:cd18256  80 YTGVVEVTVSNVQELLVAADMLQLTEVVEICCEFLKGQLHPSNCIG 125

BACK

pfam07707

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...

149-250

1.66e-38

Pssm-ID: 462237 [Multi-domain] Cd Length: 103 Bit Score: 136.91 E-value: 1.66e-38

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238   149 CLGMMVLSDAHQCRRLYEFSCRMSLVHFETVRQSEDFNSLSRDTLLDLISRDELETEDERVVFEAILQWVKHDLEQRKAH 228
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKH 80

                          90       100
                  ....*....|....*....|..
gi 33354238   229 LPLLLRNVRLALLPSDCLKNAV 250
Cdd:pfam07707  81 LPELLSAVRLPLLSPQYLLNLV 102

BTB_POZ_KLHL30

cd18259

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

23-151

1.64e-36

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349568 [Multi-domain] Cd Length: 137 Bit Score: 132.65 E-value: 1.64e-36

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  23 FHKASHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQDnLHPEVLELLL 102
Cdd:cd18259  10 FCLPSHPQSILDGLQTLRSNPKLSDVTLLVGGREFPCHRSVLALCSHYFNAMFTGDFVESISARVEIKD-VDPAVMESLI 88

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 33354238 103 DFAYSSRIVINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLSPSNCLG 151
Cdd:cd18259  89 DFAYTGKLTINQGNVEALIRTSNRLQFPTVRKVCSRYLQQQIDATNCLG 137

BTB_POZ_KLHL24_KRIP6

cd18253

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-149

8.79e-36

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349562 [Multi-domain] Cd Length: 121 Bit Score: 130.34 E-value: 8.79e-36

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  28 HPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFqDNLHPEVLELLLDFAYS 107
Cdd:cd18253   1 HSESILQVFNEFRDSRLFTDVIICVEGREFPCHRAILSACSSYFRAMFCNDHRESREMLVEI-NGILAEAMDCFLQYVYT 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 33354238 108 SRIVINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLSPSNC 149
Cdd:cd18253  80 GKVKITTENVQYLFETSSLFQISPLRDACAKFLEEQLDPCNC 121

BTB_POZ_KLHL35

cd18265

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-151

1.75e-35

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349574 [Multi-domain] Cd Length: 128 Bit Score: 129.51 E-value: 1.75e-35

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  28 HPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQDnLHPEVLELLLDFAYS 107
Cdd:cd18265   6 HAERILQVLNAYRRSGTFTDVVLLVDGKDFPCHRATLSANSAYFRAMFGGHLKESRQAVVEIQK-VSAAAMEVLLDYMYG 84

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 33354238 108 SRIVINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLSPSNCLG 151
Cdd:cd18265  85 GGLRIQEDNVESVLEASDLLQVSKLREACVRFLEGQLHPCNCLG 128

BTB_POZ_KLHL8

cd18238

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

36-151

4.54e-35

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349547 [Multi-domain] Cd Length: 120 Bit Score: 128.18 E-value: 4.54e-35

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  36 LNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQDnLHPEVLELLLDFAYSSRIVINEE 115
Cdd:cd18238   6 LHQFYENGELCDVTLKVGEKSIHCHRLVLACVSPYFRAMFTSEMAESKQDSITIKD-IDEEAVELLVDFAYTGKLTLTVD 84

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 33354238 116 NAESLLEAGDMLQFHDVRDAAAEFLEKNLSPSNCLG 151
Cdd:cd18238  85 NVQSLLYAASLLQVEEVAKACCEFMKDHLHPSNCLG 120

BTB_POZ_KLHL38

cd18268

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

31-152

2.76e-34

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349577 [Multi-domain] Cd Length: 129 Bit Score: 126.44 E-value: 2.76e-34

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  31 CVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQdNLHPEVLELLLDFAYSSRI 110
Cdd:cd18268   9 ELLRQLNSLRQERILTDVILCTGDKEIPCHRNVLASSSPYFRAMFCNNFRESSQAKVDLK-GIDSDVLDQIVDYVYTGEI 87

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 33354238 111 VINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLSPSNCLGM 152
Cdd:cd18268  88 LITRDNVLPLMEAASMLQYPKLFEACSLYLQDQLTPENCLSM 129

BACK

smart00875

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...

149-248

4.15e-34

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.

Pssm-ID: 197943 [Multi-domain] Cd Length: 101 Bit Score: 124.76 E-value: 4.15e-34

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238    149 CLGMMVLSDAHQCRRLYEFSCRMSLVHFETVRQSEDFNSLSRDTLLDLISRDELETEDERVVFEAILQWVKHDLEQRKAH 228
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREH 80

                           90       100
                   ....*....|....*....|
gi 33354238    229 LPLLLRNVRLALLPSDCLKN 248
Cdd:smart00875  81 LPELLEHVRLPLLSPDYLLE 100

BTB_POZ_KBTBD6_7

cd18273

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

26-153

2.86e-31

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349582 [Multi-domain] Cd Length: 142 Bit Score: 118.39 E-value: 2.86e-31

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  26 ASHPDCVLAHLNTLRKHCMFTDVTL--------WAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQDnLHPEV 97
Cdd:cd18273   7 AAHARALLAQLKSFYDARLLTDVTIevngpgsgPGSGRLFPCNRNVLAAASPYFKSMFTGGLYESKQETVTIHD-VDSES 85

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 33354238  98 LELLLDFAYSSRIVINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLSPSNCLGMM 153
Cdd:cd18273  86 MALIIDYCYTGRVTLSEANVQRLYAAANMLQLEYVREACASFLARRLDLSNCVGIL 141

BTB_POZ_KLHL2-like

cd18235

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

36-146

3.15e-31

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349544 [Multi-domain] Cd Length: 121 Bit Score: 117.53 E-value: 3.15e-31

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  36 LNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQDnLHPEVLELLLDFAYSSRIVINEE 115
Cdd:cd18235  12 MNELRKQNLLCDVILVADGVEIPAHRVVLASCSPYFHAMFTGDLSESRANRVTLQD-VDGKALLLLIDYVYTAEIQVTEE 90

                        90       100       110
                ....*....|....*....|....*....|.
gi 33354238 116 NAESLLEAGDMLQFHDVRDAAAEFLEKNLSP 146
Cdd:cd18235  91 NVQVLLPAANLLQLTDVRDACCDFLQSQLHP 121

BTB

pfam00651

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...

36-144

8.25e-31

Pssm-ID: 395526 [Multi-domain] Cd Length: 107 Bit Score: 115.82 E-value: 8.25e-31

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238    36 LNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQDnLHPEVLELLLDFAYSSRIvINEE 115
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDD-VSPEDFEALLEFMYTGKL-ISEE 78

                          90       100
                  ....*....|....*....|....*....
gi 33354238   116 NAESLLEAGDMLQFHDVRDAAAEFLEKNL 144
Cdd:pfam00651  79 NVDDLLAAADKLQIPSLVDKCEEFLIKSL 107

BTB_POZ_KLHL7

cd18237

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

26-151

1.52e-30

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349546 [Multi-domain] Cd Length: 126 Bit Score: 116.05 E-value: 1.52e-30

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  26 ASHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQDnLHPEVLELLLDFA 105
Cdd:cd18237   2 AKLLADFMGVMNNMRKQKTLCDVILIVEGREIKAHRVVLAAASHFFHLMFTSNMTESKSSEVELKD-AEPDIIELLVEFA 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 33354238 106 YSSRIVINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLSPSNCLG 151
Cdd:cd18237  81 YTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQLDASNCLG 126

BTB_POZ_KLHL12_C3IP1_DKIR

cd18242

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

27-149

1.77e-30

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349551 [Multi-domain] Cd Length: 124 Bit Score: 115.62 E-value: 1.77e-30

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  27 SHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQdNLHPEVLELLLDFAY 106
Cdd:cd18242   3 SHAKSILNTMNSLRKSNTLCDVTLRVEGKEFPAHRIVLAACSDYFCAMFTSEMSEKGKSEVELQ-GLTASTMEILLDFVY 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 33354238 107 SSRIVINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLSPSNC 149
Cdd:cd18242  82 TETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSNC 124

NanM

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

424-572

3.05e-30

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

Pssm-ID: 442289 [Multi-domain] Cd Length: 277 Bit Score: 119.88 E-value: 3.05e-30

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238 424 WTMVAPMRDGVSNAAVVSAKLKLFVFGGTSiHRDMVSKVQCFDPSENRWTIKAECPQPWR-YTAAAVLGSQIFIMGGDTE 502
Cdd:COG3055   3 WSSLPDLPTPRSEAAAALLDGKVYVAGGLS-GGSASNSFEVYDPATNTWSELAPLPGPPRhHAAAVAQDGKLYVFGGFTG 81

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 33354238 503 YTA-----ASAYRFDCETNQWTRIGDMTAKRMSCHAVASGNKLYVVGGYFGTQRCKTLDCYDPTSDTWNCITTVP 572
Cdd:COG3055  82 ANPsstplNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLP 156

BTB_POZ_ZBTB_KLHL-like

cd18186

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

45-127

3.45e-30

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349497 [Multi-domain] Cd Length: 82 Bit Score: 113.42 E-value: 3.45e-30

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  45 FTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQDnLHPEVLELLLDFAYSSRIVINEENAESLLEAG 124
Cdd:cd18186   1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESSSSEIELDD-VSPEAFEALLDYIYTGELELSEENVEELLAAA 79


                ...
gi 33354238 125 DML 127
Cdd:cd18186  80 DKL 82

BTB_POZ_KLHL20_KLEIP

cd18249

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-151

7.99e-30

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349558 [Multi-domain] Cd Length: 128 Bit Score: 114.09 E-value: 7.99e-30

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  28 HPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQDnLHPEVLELLLDFAYS 107
Cdd:cd18249   6 HPRQTLEAINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVTIRD-IDERAMELLIDFAYT 84

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 33354238 108 SRIVINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLSPSNCLG 151
Cdd:cd18249  85 SQITVEEGNVQTLLPAACLLQLAEIQEVCCEFLKRQLDPSNCLG 128

BTB_POZ_KLHL18

cd18247

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

36-142

1.70e-29

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349556 [Multi-domain] Cd Length: 116 Bit Score: 112.37 E-value: 1.70e-29

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  36 LNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQDnLHPEVLELLLDFAYSSRIVINEE 115
Cdd:cd18247  10 MEEIRRQGKLCDVTLKVGDQKFSAHRIVLAATIPYFHAMFTHDMVESKQDEITMQG-IEPSALEALINFAYSGRIAIDTS 88

                        90       100
                ....*....|....*....|....*..
gi 33354238 116 NAESLLEAGDMLQFHDVRDAAAEFLEK 142
Cdd:cd18247  89 NVQSLLVGASFLQLQSVKDACCEFLKE 115

BACK_KLHL12

cd18452

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also ...

144-271

2.43e-29

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also termed CUL3-interacting protein 1 (C3IP1), or DKIR, is a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport.

Pssm-ID: 350527 [Multi-domain] Cd Length: 136 Bit Score: 112.88 E-value: 2.43e-29

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238 144 LSPSNCLGMMVLSDAHQCRRLYEFSCRMSLVHFETVRQSEDFNSLSRDTLLDLISRDELETEDERVVFEAILQWVKHDLE 223
Cdd:cd18452   1 LDPSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFMLLSQEEVEKLIKSDEIQVDSEEPVFEAVLNWVKHDKE 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 33354238 224 QRKAHLPLLLRNVRLALLPSDCLKNAVSGEALLMAD-ECTKLIlDEAFR 271
Cdd:cd18452  81 EREDYLPELLQYVRLPLLSPRYITDVVDAEPLIRCSlECRDLV-DEAKK 128

BTB_POZ_KLHL1-like

cd18234

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

46-150

2.96e-29

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349543 [Multi-domain] Cd Length: 105 Bit Score: 111.30 E-value: 2.96e-29

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  46 TDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQDNlHPEVLELLLDFAYSSRIVINEENAESLLEAGD 125
Cdd:cd18234   2 CDVILIAGDRRIPAHRLVLSAVSDYFAAMFTNDVREATEEEIKLKDV-DPDALWTLVQYCYTGRLELKEDNVESLLATAC 80

                        90       100
                ....*....|....*....|....*
gi 33354238 126 MLQFHDVRDAAAEFLEKNLSPSNCL 150
Cdd:cd18234  81 LLQLSEVVEACCGFLMKQLHPSNCL 105

BTB_POZ_KLHL19_KEAP1

cd18248

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

27-144

1.73e-28

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349557 [Multi-domain] Cd Length: 124 Bit Score: 110.16 E-value: 1.73e-28

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  27 SHPDCVLAHLNTLRKHCMFTDVTLWAG----DRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQDnLHPEVLELLL 102
Cdd:cd18248   3 DHTKEAFQIMNELRLSQQLCDVTLKVKyqdpKEEFMAHKVVLASSSPYFKAMFTSGLRECGMEVVPIEG-VHPCVMSRLI 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 33354238 103 DFAYSSRIVINEENAESLLEAGDMLQFHDVRDAAAEFLEKNL 144
Cdd:cd18248  82 EFAYTASISVGEKCVLHVLPGAVMYQMDSVVKACCDFLEQQL 123

BTB_POZ_NS1BP

cd18306

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-151

3.52e-27

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349615 [Multi-domain] Cd Length: 124 Bit Score: 106.19 E-value: 3.52e-27

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  28 HPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFqDNLHPEVLELLLDFAYS 107
Cdd:cd18306   1 HPESVLAKLNALRKNRQFCDVILQVGGHEIPAHRAVLACASPYLFELFSSDSDGESILTVKL-DGLDPDAVEVLVNYAYT 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 33354238 108 SRIVINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLSPSNCLG 151
Cdd:cd18306  80 SRLEVPADLVKSVYSAAKKLKMDRVKKACGDFLLEKLTPQNCIG 123

BTB_POZ_KLHL23

cd18252

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

26-151

5.84e-27

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349561 [Multi-domain] Cd Length: 127 Bit Score: 105.68 E-value: 5.84e-27

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  26 ASHPDCVLAHLNTLRKHCMFTDVTLWAGD-RAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQdNLHPEVLELLLDF 104
Cdd:cd18252   2 SSHPADFLDAFRTFYLDGLFTDITLQCASgQIFHCHKAALAACSSYFKVMFTADMKEKSNNVIKLS-GIDHDILEALVNY 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 33354238 105 AYSSRIVINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLSPSNCLG 151
Cdd:cd18252  81 VYTSQICITERNVQSLLEAADLLQFISVKKACEQFLVRHLDIDNCLG 127

BTB_POZ_KLHL6

cd18236

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

36-151

8.25e-27

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349545 [Multi-domain] Cd Length: 129 Bit Score: 105.32 E-value: 8.25e-27

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  36 LNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQdNLHPEVLELLLDFAYSSRIVINEE 115
Cdd:cd18236  15 LENLRLENSLTDVILCVDSQEFSCHRVVLAAASNYFRAMFCNDLKEKYEEKIIIK-GVDAETMQILLDYTYTSKVLITKQ 93

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 33354238 116 NAESLLEAGDMLQFHDVRDAAAEFLEKNLSPSNCLG 151
Cdd:cd18236  94 NVQRVLEAASLFQFLRMVDACASFLTEALHPENCVG 129

BACK_KLHL18

cd18457

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as ...

144-241

1.05e-26

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A.

Pssm-ID: 350532 [Multi-domain] Cd Length: 107 Bit Score: 104.31 E-value: 1.05e-26

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238 144 LSPSNCLGMMVLSDAHQCRRLYEFSCRMSLVHFETVRQSEDFNSLSRDTLLDLISRDELETEDERVVFEAILQWVKHDLE 223
Cdd:cd18457   1 LHPNNCLGIRQFAETMMCSSLVDAANKYIQQHFIEVSKSEEFLALSKEEVLEILSRDELNVKSEEQVFEAALAWVKYDRE 80

                        90
                ....*....|....*...
gi 33354238 224 QRKAHLPLLLRNVRLALL 241
Cdd:cd18457  81 NREEYLPELLSKVRLPLL 98

BACK_KLHL2_like

cd18445

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This ...

144-256

3.58e-26

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This subfamily includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. Both KLHL2 and KLHL3 function as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins.

Pssm-ID: 350520 [Multi-domain] Cd Length: 114 Bit Score: 103.08 E-value: 3.58e-26

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238 144 LSPSNCLGMMVLSDAHQCRRLYEFSCRMSLVHFETVRQSEDFNSLSRDTLLDLISRDELETEDERVVFEAILQWVKHDLE 223
Cdd:cd18445   1 LHPSNCLGIRAFADLHSCTDLLKYAQTYTEQHFSEVVKGEEFLLLSKEQVCELISSDDLTVPSEEKVFEAVMSWVNHDPE 80

                        90       100       110
                ....*....|....*....|....*....|...
gi 33354238 224 QRKAHLPLLLRNVRLALLPSDCLKNAVSGEALL 256
Cdd:cd18445  81 NRKEHLAELLEHVRLPLLSPEYLVQRVEEEELI 113

BTB

smart00225

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...

47-144

4.09e-26

Pssm-ID: 197585 [Multi-domain] Cd Length: 97 Bit Score: 102.38 E-value: 4.09e-26

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238     47 DVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQDnLHPEVLELLLDFAYSSRIVINEENAESLLEAGDM 126
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDD-VSPEDFRALLNFLYTGKLDLPEENVEELLELADY 79

                           90
                   ....*....|....*...
gi 33354238    127 LQFHDVRDAAAEFLEKNL 144
Cdd:smart00225  80 LQIPGLVELCEEFLLKLL 97

BACK_KLHL3

cd18513

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as ...

144-271

1.00e-25

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as a substrate adapter in Cullin3 (Cul3) E3 ubiquitin ligase complexes. It is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation.

Pssm-ID: 350588 [Multi-domain] Cd Length: 130 Bit Score: 102.45 E-value: 1.00e-25

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238 144 LSPSNCLGMMVLSDAHQCRRLYEFSCRMSLVHFETVRQSEDFNSLSRDTLLDLISRDELETEDERVVFEAILQWVKHDLE 223
Cdd:cd18513   1 LHPTNCLGIRAFADVHTCTELLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISWIKYDKE 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 33354238 224 QRKAHLPLLLRNVRLALLPSDCLKNAVSGEALLMADECTKLILDEAFR 271
Cdd:cd18513  81 ARLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMK 128

BTB_POZ_KLHL26

cd18255

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-149

1.47e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349564 [Multi-domain] Cd Length: 121 Bit Score: 101.70 E-value: 1.47e-25

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  28 HPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQdNLHPEVLELLLDFAYS 107
Cdd:cd18255   1 HSVTLLQGLNALRAKGQLLDVTLIADGQRFQAHKVVLASCSDYFRAMFTGGMRESSQDEIELK-GVSAKGLKHILDFAYT 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 33354238 108 SRIVINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLSPSNC 149
Cdd:cd18255  80 SELTLDLDCIQDVLGAAVHLQMLPVVELCEEFLKSAMSVENC 121

BTB_POZ_KLHL10

cd18240

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

36-149

4.18e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349549 [Multi-domain] Cd Length: 120 Bit Score: 100.48 E-value: 4.18e-25

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  36 LNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQDnLHPEVLELLLDFAYSSRIVINEE 115
Cdd:cd18240   8 FNELRLEGKLCDVVIRVNGVEFPAHRNILCACSPYFRALFTNGWNETEKKVYKIPG-VSPEMMELIIEYAYTRTVPITAE 86

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 33354238 116 NAESLLEAGDmlQFH--DVRDAAAEFLEKNLSPSNC 149
Cdd:cd18240  87 NVEELLPAAD--QFNimGIVKACCDFLEDQLCPENC 120

BACK_KLHL1_like

cd18444

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; ...

144-242

7.71e-25

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This subfamily contains Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. Members of this subfamily contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels.

Pssm-ID: 350519 [Multi-domain] Cd Length: 106 Bit Score: 98.94 E-value: 7.71e-25

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238 144 LSPSNCLGMMVLSDAHQCRRLYEFSCRMSLVHFETVRQSEDFNSLSRDTLLDLISRDELETEDERVVFEAILQWVKHDLE 223
Cdd:cd18444   2 LHPSNCLGIRSFADAQGCTDLLKVAHNYTMEHFMEVIQNQEFLLLPAEEVAKLLASDDLNVPSEETIFHALLLWVKHDLP 81

                        90
                ....*....|....*....
gi 33354238 224 QRKAHLPLLLRNVRLALLP 242
Cdd:cd18444  82 ERKKHLAKLLALIRLPLLT 100

BTB_POZ_KLHL40-like

cd18269

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

36-150

1.16e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349578 [Multi-domain] Cd Length: 133 Bit Score: 99.40 E-value: 1.16e-24

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  36 LNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFqDNLHPEVLELLLDFAYSSRIVINEE 115
Cdd:cd18269  18 LKDLLDENKFVDCVLKIGDKEFPCHRLVLAACSPYFRAMFLSDLEESKKKEVVL-EDVDPDVMGMILKYLYTSEIDLNDQ 96

                        90       100       110
                ....*....|....*....|....*....|....*
gi 33354238 116 NAESLLEAGDMLQFHDVRDAAAEFLEKNLSPSNCL 150
Cdd:cd18269  97 NVQDIFALASRFQIPSIFTVCVSYLQKRLSLSNCL 131

BTB_POZ_KLHL28_BTBD5

cd18257

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-146

2.61e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349566 [Multi-domain] Cd Length: 118 Bit Score: 97.99 E-value: 2.61e-24

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  28 HPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQdNLHPEVLELLLDFAYS 107
Cdd:cd18257   1 HSEQLLQGLNLLRQHHELCDVVLRVGDVKIHAHKVVLASCSPYFKAMFTGNLSEKENSEVEFQ-CIDETALQAIVEYAYT 79

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 33354238 108 SRIVINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLSP 146
Cdd:cd18257  80 GTVFISQATVESLLPAANLLQIKLVLKECCDFLESQLDP 118

BTB_POZ_KLHL4

cd18336

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

27-152

6.93e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349645 [Multi-domain] Cd Length: 126 Bit Score: 97.04 E-value: 6.93e-24

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  27 SHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQdNLHPEVLELLLDFAY 106
Cdd:cd18336   1 NHAEQTFRKMENYLQHKQLCDVLLIAGNLKIPAHRLVLSAVSDYFAAMFTNDVREAKQEEIKME-GVDPDALKALVHYAY 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 33354238 107 SSRIVINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLSPSNCLGM 152
Cdd:cd18336  80 TGVLELKEDTIESLLAAACLLQLSQVIDVCCNFLMKQLHPSNCLGI 125

BACK_KLHL2_Mayven

cd18512

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also ...

144-271

8.07e-24

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation.

Pssm-ID: 350587 [Multi-domain] Cd Length: 130 Bit Score: 97.02 E-value: 8.07e-24

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238 144 LSPSNCLGMMVLSDAHQCRRLYEFSCRMSLVHFETVRQSEDFNSLSRDTLLDLISRDELETEDERVVFEAILQWVKHDLE 223
Cdd:cd18512   1 LHPTNCLGIRAFADMHACTELLNQANTYAEQHFSDVVLSEEFLNLGIEQVCSLIASDKLTISSEEKVFEAVIAWVNHDKE 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 33354238 224 QRKAHLPLLLRNVRLALLPSDCLKNAVSGEALLMADECTKLILDEAFR 271
Cdd:cd18512  81 VRQEHMAHLMEHVRLPLLSREYLVQRVEEETLVKNSSACKDYLIEAMK 128

BTB_POZ_KLHL40_KBTBD5

cd18340

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

36-152

9.75e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349649 [Multi-domain] Cd Length: 134 Bit Score: 96.83 E-value: 9.75e-24

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  36 LNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQDnLHPEVLELLLDFAYSSRIVINEE 115
Cdd:cd18340  18 LKDLLDHNKFVDCVLKIKEKEFPCHRLVLAACSPYFRAMFLSDLEESKKREIVLED-VDPDVMGKILHYIYTSEIEITEQ 96

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 33354238 116 NAESLLEAGDMLQFHDVRDAAAEFLEKNLSPSNCLGM 152
Cdd:cd18340  97 NVQDIFAAANMFQIPSIFTVCVSFLQKRLCLSNCLAI 133

BACK_KLHL29_KBTBD9

cd18468

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also ...

146-243

4.47e-23

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also termed Kelch repeat and BTB domain-containing protein 9 (KBTBD9), belongs to the KLHL family. Its function remains unclear. A nuclear receptor subfamily 5, group A, member 2 (NR5A2)-Kelch-like family member 29 (KLHL29) fusion transcript may participate in the origin or progression of some colon cancers.

Pssm-ID: 350543 [Multi-domain] Cd Length: 102 Bit Score: 94.02 E-value: 4.47e-23

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238 146 PSNCLGMMVLSDAHQCRRLYEFSCRMSLVHFETVRQSEDFNSLSRDTLLDLISRDELETEDERVVFEAILQWVKHDLEQR 225
Cdd:cd18468   2 PSNCLGIWALAEALQCTELHNMAKAYALQNFPDVARQEEILSISKDDIVEYLSHDSLNTKAEELVFETAIKWLKKDPKNR 81

                        90
                ....*....|....*....
gi 33354238 226 KAHLPLLLRNVRLALL-PS 243
Cdd:cd18468  82 KQHIAELLAVVRLPFIhPS 100

BACK_KLHL20

cd18459

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also ...

144-241

5.75e-23

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also termed Kelch-like ECT2-interacting protein (KLEIP), or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis.

Pssm-ID: 350534 [Multi-domain] Cd Length: 100 Bit Score: 93.65 E-value: 5.75e-23

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238 144 LSPSNCLGMMVLSDAHQCRRLYEFSCRMSLVHFETVRQSEDFNSLSRDTLLDLISRDELETEDERVVFEAILQWVKHDLE 223
Cdd:cd18459   2 LDPSNCLGIRAFADTHACRELLRIADKFTQHNFQEVMESEEFMLLPVNQLIDIISSDELNVRSEEQVFNAVMAWVKYNIQ 81

                        90
                ....*....|....*...
gi 33354238 224 QRKAHLPLLLRNVRLALL 241
Cdd:cd18459  82 ERRPHLPQVLQHVRLPLL 99

BTB_POZ_KBTBD3_BKLHD3

cd18271

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

27-150

9.69e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349580 [Multi-domain] Cd Length: 130 Bit Score: 94.13 E-value: 9.69e-23

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  27 SHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQdNLHPEVLELLLDFAY 106
Cdd:cd18271   6 CHGQQILSVLQNFREQNAFFDFNIIVKDETIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTIS-NLSPKAVKAFLDYAY 84

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 33354238 107 SSRIVINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLSPSNCL 150
Cdd:cd18271  85 TGKAEITDDNVEMFFQMSSFLQVSLLSKACSDFLIKSIDLTNCL 128

BTB_POZ_KBTBD8

cd18274

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

26-152

1.46e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349583 [Multi-domain] Cd Length: 129 Bit Score: 93.51 E-value: 1.46e-22

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  26 ASHPDCVLAHLNTLRKHCMFTDVTLWAG-DRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQdNLHPEVLELLLDF 104
Cdd:cd18274   3 PLHACSILQQLKAMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIV-GVEAESMHLVLDY 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 33354238 105 AYSSRIVINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLSPSNCLGM 152
Cdd:cd18274  82 AYTSRVTLTEANVQALFTAASIFQIPSLQDQCAQFMISRLDPQNSIGV 129

BACK_KLHL38

cd18476

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs ...

144-238

2.12e-22

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs to the KLHL family. Its function remains unclear. The klhl38 gene has recently been identified as a possible diapause (a temporary arrest of development during early ontogeny) gene, as it is significantly up-regulated during diapause. It may also be involved in chicken preadipocyte differentiation.

Pssm-ID: 350551 [Multi-domain] Cd Length: 99 Bit Score: 91.73 E-value: 2.12e-22

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238 144 LSPSNCLGMMVLSDAHQCRRLYEFSCRMSLVHFETVRQSEDFNSLSRDTLLDLISRDELETEDERvVFEAILQWVKHDLE 223
Cdd:cd18476   1 LTPSNCLSMIRLSEILNCETLKKKAKDMALQCFPDVAASEDLKELCASELLDYLGDDELCGEEEQ-VFETLMVWIRHDPK 79

                        90
                ....*....|....*
gi 33354238 224 QRKAHLPLLLRNVRL 238
Cdd:cd18476  80 ARKGYIHDLFKKVRL 94

BTB_POZ_KLHL16_gigaxonin

cd18245

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

33-141

2.95e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349554 [Multi-domain] Cd Length: 111 Bit Score: 92.02 E-value: 2.95e-22

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  33 LAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQ-DNLHPEVLELLLDFAYSSRIV 111
Cdd:cd18245   2 LRALNSFREEPHLCDATLVVGGEEIPVQKNVLAAASPYFRAKLNYNPPKDDGSTYKIElEGISVEVMEEILDYIYTGQIK 81

                        90       100       110
                ....*....|....*....|....*....|
gi 33354238 112 INEENAESLLEAGDMLQFHDVRDAAAEFLE 141
Cdd:cd18245  82 LSEDNIQDIVQAADLLLMTDLKDLCCEFLE 111

BTB_POZ_KLHL29_KBTBD9

cd18258

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

29-151

3.23e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349567 [Multi-domain] Cd Length: 125 Bit Score: 92.34 E-value: 3.23e-22

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  29 PDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVN--FQDNLHPEVLELLLDFAY 106
Cdd:cd18258   1 PKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSSRDSGGGEKLelTMSNINADVLELLLEFVY 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 33354238 107 SSRIVINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLSPSNCLG 151
Cdd:cd18258  81 TGSLIIDSANAKTLLEAANKFQFHTFCKVCVSFLEKQLTASNCLG 125

BTB_POZ_KBTBD2_BKLHD1

cd18270

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

32-153

3.55e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349579 [Multi-domain] Cd Length: 133 Bit Score: 92.37 E-value: 3.55e-22

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  32 VLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQdNLHPEVLELLLDFAYSSRIV 111
Cdd:cd18270  13 LLEQLKFFYEQQLLTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQTHVHLR-NVDAATLQIIITYAYTGNLA 91

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 33354238 112 INEENAESLLEAGDMLQFHDVRDAAAEFLEKNLSPSNCLGMM 153
Cdd:cd18270  92 INDSTVEQLYETACFLQVEDVLQRCREYLIKKINAENCVRLL 133

BTB_POZ_KLHL5

cd18337

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

23-152

4.58e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It is abundantly expressed in the ovary, adrenal gland, and thymus. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349646 [Multi-domain] Cd Length: 130 Bit Score: 92.05 E-value: 4.58e-22

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  23 FHKASHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQdNLHPEVLELLL 102
Cdd:cd18337   1 FQALNHAEQTFKKMENYLRHKQLCDVVLVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREAKQEEIKME-GVEPNALWALV 79

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 33354238 103 DFAYSSRIVINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLSPSNCLGM 152
Cdd:cd18337  80 QYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGI 129

BTB_POZ_KLHL2_Mayven

cd18338

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

36-146

9.01e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349647 [Multi-domain] Cd Length: 121 Bit Score: 90.90 E-value: 9.01e-22

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  36 LNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQDnLHPEVLELLLDFAYSSRIVINEE 115
Cdd:cd18338  12 MNELRSQNLLCDVTIVAEDVEIAAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKE-VDGWTLKMLIDYVYTAEIQVTEE 90

                        90       100       110
                ....*....|....*....|....*....|.
gi 33354238 116 NAESLLEAGDMLQFHDVRDAAAEFLEKNLSP 146
Cdd:cd18338  91 NVQVLLPAAGLLQLQDVKKTCCEFLESQLHP 121

BTB_POZ_KLHL3

cd18339

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

36-146

2.05e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349648 [Multi-domain] Cd Length: 121 Bit Score: 89.78 E-value: 2.05e-21

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  36 LNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQDnLHPEVLELLLDFAYSSRIVINEE 115
Cdd:cd18339  12 MNELRSKQLLCDVTIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKD-VDGQTLSKLIDYIYTAEIEVTEE 90

                        90       100       110
                ....*....|....*....|....*....|.
gi 33354238 116 NAESLLEAGDMLQFHDVRDAAAEFLEKNLSP 146
Cdd:cd18339  91 NVQVLLPAASLLQLMDVRQNCCDFLQSQLHP 121

BACK_KLHL19_KEAP1

cd18458

BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); ...

143-233

3.31e-21

BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also termed cytosolic inhibitor of Nrf2 (INrf2), or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression.

Pssm-ID: 350533 [Multi-domain] Cd Length: 91 Bit Score: 88.12 E-value: 3.31e-21

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238 143 NLSPSNCLGMMVLSDAHQCRRLY----EFSCRmslvHFETVRQSEDFNSLSRDTLLDLISRDELETEDERVVFEAILQWV 218
Cdd:cd18458   1 QLDPSNCIGIANFAEQHGCTELHkkarEYIYM----HFSEVSQSEEFFNLSPCQLVALISRDELNVRCESEVYNAVIRWV 76

                        90
                ....*....|....*
gi 33354238 219 KHDLEQRKAHLPLLL 233
Cdd:cd18458  77 KYDEENRRQYLEALL 91

BACK_KLHL1

cd18509

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a ...

144-248

1.43e-20

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton in brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.

Pssm-ID: 350584 [Multi-domain] Cd Length: 106 Bit Score: 87.00 E-value: 1.43e-20

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238 144 LSPSNCLGMMVLSDAHQCRRLYEFSCRMSLVHFETVRQSEDFNSLSRDTLLDLISRDELETEDERVVFEAILQWVKHDLE 223
Cdd:cd18509   2 LHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQ 81

                        90       100
                ....*....|....*....|....*
gi 33354238 224 QRKAHLPLLLRNVRLALLPSDCLKN 248
Cdd:cd18509  82 RRCSDLSMLLAYIRLPLLPPQLLAD 106

BACK_KLHL17

cd18456

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also ...

144-244

1.59e-20

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also termed actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GluR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in the actin-based neuronal function.

Pssm-ID: 350531 [Multi-domain] Cd Length: 102 Bit Score: 86.59 E-value: 1.59e-20

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238 144 LSPSNCLGMMVLSDAHQCRRLYEFSCRMSLVHFETVRQSEDFNSLSRDTLLDLISRDELETEDERVVFEAILQWVKHDLE 223
Cdd:cd18456   1 LDPSNCLGIRGFADTHSCSDLLKSAHKYVLQHFVEVSKTEEFMLLPLKQVLDLISSDSLNVPSEEEVYRAVLSWVKHDVD 80

                        90       100
                ....*....|....*....|.
gi 33354238 224 QRKAHLPLLLRNVRLALLPSD 244
Cdd:cd18456  81 GRRQHVPRLMKCVRLPLLSRD 101

BTB_POZ_KBTBD12

cd18276

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

25-152

1.75e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349585 [Multi-domain] Cd Length: 127 Bit Score: 87.55 E-value: 1.75e-20

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  25 KASHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQDnLHPEVLELLLDF 104
Cdd:cd18276   1 RQKHSLTLLDQLNRMKELAELTDVVLVAEGEKFPCHRLVLAAFSPYFKAMFTCGLMECSQREVVLHD-ITAESVSIILNY 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 33354238 105 AYSSRIVINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLSPSNCLGM 152
Cdd:cd18276  80 MYSSDLHLTNSNVQGVATAAFFLQMEDIFSVCQKYMMDHMDASNCLGI 127

BACK_KLHL24

cd18463

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also ...

144-220

2.95e-20

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6), or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of the BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation.

Pssm-ID: 350538 [Multi-domain] Cd Length: 78 Bit Score: 85.14 E-value: 2.95e-20

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 33354238 144 LSPSNCLGMMVLSDAHQCRRLYEFSCRMSLVHFETVRQSEDFNSLSRDTLLDLISRDELETEDERVVFEAILQWVKH 220
Cdd:cd18463   2 LDPCNCLGIQKFADTHSLKQLFEKCKKFALENFVEVSQHEEFLELCKDELIEYISNDELVVPKEEEVFEAVMRWVYH 78

BTB_POZ_KLHL32

cd18261

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

24-150

4.38e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349570 [Multi-domain] Cd Length: 133 Bit Score: 86.56 E-value: 4.38e-20

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  24 HKASHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQdNLHPEVLELLLD 103
Cdd:cd18261   7 QSKSHKDAVLAALNQQRNDGILCDITLVAEEQKFHAHKAVLAACSDYFRAMFSLCMVESEADEVNLH-GVTSLGLKQALD 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 33354238 104 FAYSSRIVINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLSPSNCL 150
Cdd:cd18261  86 FAYTGQILLEPGVIQDVLAAGSHLQLLELLSLCSHYLIQELNSFNYL 132

BACK_KLHL4

cd18510

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares ...

144-246

4.45e-20

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.

Pssm-ID: 350585 [Multi-domain] Cd Length: 106 Bit Score: 85.74 E-value: 4.45e-20

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238 144 LSPSNCLGMMVLSDAHQCRRLYEFSCRMSLVHFETVRQSEDFNSLSRDTLLDLISRDELETEDERVVFEAILQWVKHDLE 223
Cdd:cd18510   2 LHPSNCLGIRSFGDAQGCTELLKVAHSYTMEHFLEVIKNQEFLLLPASEIVKLLASDDINVPDEETIFQALMMWVRHDLQ 81

                        90       100
                ....*....|....*....|...
gi 33354238 224 QRKAHLPLLLRNVRLALLPSDCL 246
Cdd:cd18510  82 NRQKDLGMLLSYIRLPLLPPQLL 104

BTB_POZ_KLHL17_actinfilin

cd18246

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

36-146

5.86e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349555 [Multi-domain] Cd Length: 139 Bit Score: 86.24 E-value: 5.86e-20

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  36 LNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQDnLHPEVLELLLDFAYSSRIVINEE 115
Cdd:cd18246  30 MNRMRQRGLLCDIVLHVGTKEIKAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHD-IDPQALEQLVQYAYTAEIVVGEG 108

                        90       100       110
                ....*....|....*....|....*....|.
gi 33354238 116 NAESLLEAGDMLQFHDVRDAAAEFLEKNLSP 146
Cdd:cd18246 109 NVQTLLPAASLLQLNGVRDACCKFLLSQLDP 139

BACK_KLHL16_gigaxonin

cd18455

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, ...

145-241

7.82e-20

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, also termed Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy.

Pssm-ID: 350530 [Multi-domain] Cd Length: 97 Bit Score: 84.68 E-value: 7.82e-20

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238 145 SPSNCLGMMVLSDAHQCRRLYEFSCRMSLVHFETVRQSEDFNSLSRDTLLDLISRDELETEDERVVFEAILQWVKHDLEQ 224
Cdd:cd18455   1 SAENCIGIRDFAERFSCPHVHYVATEYLETHFRDVSSTEEFLELSPEKLKELLSRDKLNVGNEEYIFEAVLRWVRHDPEE 80

                        90
                ....*....|....*..
gi 33354238 225 RKAHLPLLLRNVRLALL 241
Cdd:cd18455  81 RKVHLKDLMSSCWRSGL 97

BTB_POZ_KLHL41_KBTBD10

cd18341

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

45-152

1.24e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349650 [Multi-domain] Cd Length: 133 Bit Score: 85.28 E-value: 1.24e-19

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  45 FTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFqDNLHPEVLELLLDFAYSSRIVINEENAESLLEAG 124
Cdd:cd18341  27 FVDCTLKAGDKSLPCHRLILAACSPYFREYFLSEESEEKKKEVVL-DNVDPNIMDMILKYLYSAEIDLNDGNVQDIFALA 105

                        90       100
                ....*....|....*....|....*...
gi 33354238 125 DMLQFHDVRDAAAEFLEKNLSPSNCLGM 152
Cdd:cd18341 106 SRFQIPSVFTVCVTYLQKRLSPANCLAI 133

BTB_POZ_KLHL36

cd18266

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

22-150

1.41e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349575 [Multi-domain] Cd Length: 135 Bit Score: 84.94 E-value: 1.41e-19

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  22 VFHKASHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQDNLHPEvLELL 101
Cdd:cd18266   2 VYRWADHSNLVLQGLNEQRQRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAHQKEVELVGASYIG-LKAV 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 33354238 102 LDFAYSSRIVINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLSPSNCL 150
Cdd:cd18266  81 IDFLYSSELPLDGGNIDYVLETAHLLQIWKVVDFCCEYLENEVSEENYL 129

BTB_POZ_KLHL34

cd18264

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

18-149

3.27e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349573 [Multi-domain] Cd Length: 136 Bit Score: 84.08 E-value: 3.27e-19

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  18 MNISVFHKASHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQdNLHPEV 97
Cdd:cd18264   1 MSYFLAYSKSHGEAVLSQYQSLRAEGFLCDVVLEAEGNEFPAHRSLLACSSDYFRALFKDYTQESKARVIHLP-VVSAAG 79

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 33354238  98 LELLLDFAYSSRIVINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLSPSNC 149
Cdd:cd18264  80 LQRVLDFIYTSWLSLSLDTLEDTLEAASYLQVTEAIGLCSQYLINNLAPENC 131

BACK_KLHL27_IPP

cd18466

BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide ...

144-243

3.85e-19

BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also termed Kelch-like protein 27 (KLHL27), is an actin-binding protein that may play a role in organizing the actin cytoskeleton.

Pssm-ID: 350541 [Multi-domain] Cd Length: 103 Bit Score: 82.91 E-value: 3.85e-19

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238 144 LSPSNCLGMMVLSDAHQCRRLYEFSCRMSLVHFETVRQSEDFNSLSRDTLLDLISRDELETEDERVVFEAILQWVKHDLE 223
Cdd:cd18466   1 IDPANCIGIFQFSEQIACHDLLEFTENYIHVHFLEVQSGEEFLGLTKDQLVKILRSEELSIEDEYQVFTAAMEWILKDVG 80

                        90       100
                ....*....|....*....|
gi 33354238 224 QRKAHLPLLLRNVRLALLPS 243
Cdd:cd18466  81 KRKKHVVEVLEPVRFPLLPP 100

BACK_KLHL8

cd18448

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a ...

144-239

8.39e-19

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN.

Pssm-ID: 350523 [Multi-domain] Cd Length: 97 Bit Score: 81.58 E-value: 8.39e-19

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238 144 LSPSNCLGMMVLSDAHQCRRLYEFSCRMSLVHFETVRQSEDFNSLSRDTLLDLISRDELETEDERVVFEAILQWVKHDLE 223
Cdd:cd18448   2 LHPSNCLGVRTFAEQHNRVDLMKMADKYACDHFNEVVECEEFVSISAQHLEKLISSSDLNVESESQVYEAVMKWVKHDPQ 81

                        90
                ....*....|....*.
gi 33354238 224 QRKAHLPLLLRNVRLA 239
Cdd:cd18448  82 HRKRHLDDLLSQVRLP 97

BACK_KLHL5

cd18511

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares ...

144-241

2.60e-18

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. It is abundantly expressed in ovary, adrenal gland, and thymus.

Pssm-ID: 350586 [Multi-domain] Cd Length: 106 Bit Score: 80.50 E-value: 2.60e-18

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238 144 LSPSNCLGMMVLSDAHQCRRLYEFSCRMSLVHFETVRQSEDFNSLSRDTLLDLISRDELETEDERVVFEAILQWVKHDLE 223
Cdd:cd18511   2 LHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFLLLPASEIAKLLASDDMNIPNEETILNALLSWVRHDVE 81

                        90
                ....*....|....*...
gi 33354238 224 QRKAHLPLLLRNVRLALL 241
Cdd:cd18511  82 QRRKDLSKLLAYIRLPLL 99

BTB_POZ_KLHL1

cd18335

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-152

3.51e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton the brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349644 [Multi-domain] Cd Length: 126 Bit Score: 80.86 E-value: 3.51e-18

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  28 HPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQdNLHPEVLELLLDFAYS 107
Cdd:cd18335   2 HAEQTFRKMESYLKQQQLCDVILIAGNRKIPAHRLVLSAVSDYFAAMFTSDVCEAKQEEIKME-GIDPNALWDLVQFAYT 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 33354238 108 SRIVINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLSPSNCLGM 152
Cdd:cd18335  81 GCLELKEDTIENLLAAACLLQLSQVVEVCCHFLMKLLHPSNCLGI 125

PHA02790

Kelch-like protein; Provisional

63-566

4.06e-18

Kelch-like protein; Provisional

Pssm-ID: 165153 [Multi-domain] Cd Length: 480 Bit Score: 87.41 E-value: 4.06e-18

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238   63 VLAASSRYFEAMFSHGLRESRDDTVNFQDNLHPEVLELLLDFAYSSRIVINEENAESLLEAGDMLQFHDVRDAAAEFLEK 142
Cdd:PHA02790  39 ILKKLSPYFRTHLRQKYTKNKDPVTRVCLDLDIHSLTSIVIYSYTGKVYIDSHNVVNLLRASILTSVEFIIYTCINFILR 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  143 NLSPSNCLGMMVLSDAHQCRRLYEFSCRMSLVHFETVRQS--EDFNSLSRDTLLDlisRDELETEDERVVFEAILQWVKH 220
Cdd:PHA02790 119 DFRKEYCVECYMMGIEYGLSNLLCHTKDFIAKHFLELEDDiiDNFDYLSMKLILE---SDELNVPDEDYVVDFVIKWYMK 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  221 DlEQRKAHLPLLLRNV-RLALLPSDCLKNavsgeallmadecTKLILDeafrCkTKILLNDgvvtspfARPRKAGHTLLI 299
Cdd:PHA02790 196 R-RNRLGNLLLLIKNViRSNYLSPRGINN-------------VKWILD----C-TKIFHCD-------KQPRKSYKYPFI 249

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  300 lgGQTFMCDKIYQVDHKAkeiipkadlpsprkefSASAIGCKVYVTGGrGSENGVSKDVWVYDTVHEEWSKAAPMLIARF 379
Cdd:PHA02790 250 --EYPMNMDQIIDIFHMC----------------TSTHVGEVVYLIGG-WMNNEIHNNAIAVNYISNNWIPIPPMNSPRL 310

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  380 GHGSAELENCLYVVGGhtslagiFPASPSVslkqvEKYDPGDNKWTMVAPMRDGVSNAAVVSAKLKLFVFGGtsiHRDMV 459
Cdd:PHA02790 311 YASGVPANNKLYVVGG-------LPNPTSV-----ERWFHGDAAWVNMPSLLKPRCNPAVASINNVIYVIGG---HSETD 375

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  460 SKVQCFDPSENRWTIKAECPQPWRYTAAAVLGSQIFIMGGDTEytaasayrFDCE-TNQWTRIGDMTAKRMSCHAVASGN 538
Cdd:PHA02790 376 TTTEYLLPNHDQWQFGPSTYYPHYKSCALVFGRRLFLVGRNAE--------FYCEsSNTWTLIDDPIYPRDNPELIIVDN 447

                        490       500
                 ....*....|....*....|....*...
gi 33354238  539 KLYVVGGYFGTQRCKTLDCYDPTSDTWN 566
Cdd:PHA02790 448 KLLLIGGFYRGSYIDTIEVYNNRTYSWN 475

BACK_KLHL28_BTBD5

cd18467

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also ...

144-241

6.66e-18

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also termed BTB/POZ domain-containing protein 5 (BTBD5), belongs to the KLHL family. Its function remains unclear.

Pssm-ID: 350542 [Multi-domain] Cd Length: 99 Bit Score: 79.22 E-value: 6.66e-18

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238 144 LSPSNCLGMMVLSDAHQCRRLYEFSCRMSLVHFETVRQSEDFNSLSRDTLLDLISRDELETEDERVVFEAILQWVKHDLE 223
Cdd:cd18467   1 LDPGNCIGISRFAETYGCHDLYLAANKYICQNFEDVCQTEEFFELTHAELDEIVSNDCLNVVTEETVFYALESWIKYDVQ 80

                        90
                ....*....|....*...
gi 33354238 224 QRKAHLPLLLRNVRLALL 241
Cdd:cd18467  81 ERQKYLAQLLHCVRLPLL 98

BTB_POZ_KLHL9_13

cd18239

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

23-149

7.39e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13; KLHL9 and KLHL13 (also called BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes, thereby coordinating faithful mitotic progression and completion of cytokinesis. They contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349548 [Multi-domain] Cd Length: 128 Bit Score: 79.85 E-value: 7.39e-18

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  23 FHKASHPDCVLAHLNTLRKHCMFTDVTLWAGD--RAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQdNLHPEVLEL 100
Cdd:cd18239   1 FTSNTHSSVVLQGFDQLRGEGLLCDVTLVPGDgdETFPVHRAMMASASDYFKAMFTGGMKEQELMCIKLH-GVSKIGLKN 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 33354238 101 LLDFAYSSRIVINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLSPSNC 149
Cdd:cd18239  80 IIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVLLISGVTLENC 128

BTB_POZ_ZBTB8A_BOZF1

cd18329

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

26-132

1.30e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349638 [Multi-domain] Cd Length: 116 Bit Score: 78.71 E-value: 1.30e-17

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  26 ASHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQDNLHPEVLELLLDFA 105
Cdd:cd18329   2 SSHQSRLLQQLDEQRKQELFCDCSILVEGQVFKAHRNVLFASSGYFKMLLSQNAKETGQPTVATFDVFSPDTFTIILDFV 81

                        90       100
                ....*....|....*....|....*..
gi 33354238 106 YSSRIVINEENAESLLEAGDMLQFHDV 132
Cdd:cd18329  82 YSGKLSLTSQNVIEVMSAASYLQMTDV 108

BTB_POZ_KLHL11

cd18241

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

23-149

1.42e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349550 [Multi-domain] Cd Length: 135 Bit Score: 79.52 E-value: 1.42e-17

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  23 FHKASHPDCVLAHLNTLRKHCMFTDVTL---WAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQDN-----LH 94
Cdd:cd18241   1 FECSSHCSELSWRQNEQRKQGLFCDITLafgGAGGREFRAHRSVLAAATEYFTPLLSGQFSESRSGRVEMRKWssepgPD 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 33354238  95 PEVLELLLDFAYSSRIVINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLSPSNC 149
Cdd:cd18241  81 PDTVEAVIQYMYTGRIRVSTGNVHEVLELADRFLLIRLKEFCGEFLKKKLNLSNC 135

BACK_KLHL30

cd18469

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs ...

144-245

2.10e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs to the KLHL family. Its function remains unclear. Differential expression of the KLHL30 gene has been observed in glioblastoma multiforme versus normal brain.

Pssm-ID: 350544 [Multi-domain] Cd Length: 104 Bit Score: 77.87 E-value: 2.10e-17

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238 144 LSPSNCLGMMVLSDAHQCRRLYEFSCRMSLVHFETVRQSEDFNSLSRDTLLDLISRDELETEDERVVFEAILQWVKHDLE 223
Cdd:cd18469   3 IDATNCLGICEFGETHGCPEVAAKAWSFLLENFEAVSQEEEFLQLEKERLVACLGDDLLQVRDEQSRLEAVLRWVGHDPQ 82

                        90       100
                ....*....|....*....|..
gi 33354238 224 QRKAHLPLLLRNVRLALLPSDC 245
Cdd:cd18469  83 ARAAHLPELLSLVHLSLLTDQY 104

BACK_KEL_like

cd18508

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch ...

147-221

2.53e-17

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch protein (KEL) and similar proteins; KEL, also termed kelch short protein, is a component of ring canals that regulates the flow of cytoplasm between cells. It binds actin and may be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis.

Pssm-ID: 350583 [Multi-domain] Cd Length: 77 Bit Score: 76.68 E-value: 2.53e-17

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 33354238 147 SNCLGMMVLSDAHQCRRLYEFSCRMSLVHFETVRQSEDFNSLSRDTLLDLISRDELETEDERVVFEAILQWVKHD 221
Cdd:cd18508   3 TNCLGIHEFADAHSCVELEEAAQNYIYQHFNEVIQGEEFLSLDHESLTELISSDRLNVPSEERVYEAAVAWLKHD 77

BTB_POZ_ZBTB44

cd18228

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

27-144

3.86e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349537 [Multi-domain] Cd Length: 126 Bit Score: 77.98 E-value: 3.86e-17

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  27 SHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLreSRDDTVNFQDNlhPEVLEL------ 100
Cdd:cd18228   1 SHSQELLGKLNSLRNEGHFCDVTIRVQDKIFRAHKVVLAACSDFFRSKLVGQA--SPRLVLVSPAG--KCVLDLhhvtvt 76

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 33354238 101 ----LLDFAYSSRIVINEENAESLLEAGDMLQFHDVRDAAAEFLEKNL 144
Cdd:cd18228  77 gfapLLEYAYTSTLSINTENIIDVLAAASYMQMFNVANTCSEFMKSSI 124

BTB_POZ_SPOPL

cd18343

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

29-148

1.29e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349652 [Multi-domain] Cd Length: 123 Bit Score: 76.20 E-value: 1.29e-16

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  29 PDCVLAH-LNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQDnLHPEVLELLLDFAYS 107
Cdd:cd18343   4 PECRLAEdLGNLWENSRFTDCSLFVGGQEFKAHKSILAARSPVFNAMFEHEMEESKKNRVEIND-VDPEVFKEMMRFIYT 82

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 33354238 108 SRIVINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLSPSN 148
Cdd:cd18343  83 GKAPNLDKMADNLLAAADKYALERLKVMCEEALCNNLSVEN 123

BTB_POZ_SPOP-like

cd18279

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

29-148

2.59e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349588 [Multi-domain] Cd Length: 120 Bit Score: 75.26 E-value: 2.59e-16

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  29 PDCVLA-HLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQDnLHPEVLELLLDFAYS 107
Cdd:cd18279   1 PECRLAeDLGNLWENSRFTDCCLCVGGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEIND-VDPEVFKEMMRFIYT 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 33354238 108 SRIVINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLSPSN 148
Cdd:cd18279  80 GKAPNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVEN 120

BTB_POZ_ZBTB8

cd18199

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-132

6.48e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349508 [Multi-domain] Cd Length: 113 Bit Score: 74.00 E-value: 6.48e-16

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  28 HPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQDNLHPEVLELLLDFAYS 107
Cdd:cd18199   1 HQSRLLGQLNEQRKQDFFCDCSIIVEGRIFKAHRNVLFASSGYFRMLLSHYIQDTGRPSTASFDVFSSDAFSIILDFVYS 80

                        90       100
                ....*....|....*....|....*
gi 33354238 108 SRIVINEENAESLLEAGDMLQFHDV 132
Cdd:cd18199  81 GKLSLTSQNVIEVMSAASYLQMTDV 105

BACK_KLHL21

cd18460

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a ...

144-238

6.92e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively.

Pssm-ID: 350535 [Multi-domain] Cd Length: 101 Bit Score: 73.29 E-value: 6.92e-16

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238 144 LSPSNCLGMMVLSDAHQCRRLYEFSCRMSLVHFETVRQSEDFNSLSRDTLLDLISRDELETEDERVVFEAILQWVKHDLE 223
Cdd:cd18460   1 LDVSNCLEMQDFAEAFACRGLAEAAKRFILRHIVELAKGEQFERLPLKRLLEYLSDDGLCVDKEETAYQIALRWVKADPK 80

                        90
                ....*....|....*
gi 33354238 224 QRKAHLPLLLRNVRL 238
Cdd:cd18460  81 HRQHFWPELLQHVRL 95

BACK_KLHL40_like

cd18477

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The ...

144-242

8.36e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells.

Pssm-ID: 350552 [Multi-domain] Cd Length: 99 Bit Score: 72.95 E-value: 8.36e-16

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238 144 LSPSNCLGMMVLSDAHQCRRL----YEFSCRmslvHFETVRQSEDFNSLSRDTLLDLISRDELETEDERVVFEAILQWVK 219
Cdd:cd18477   1 LCLGNCLAIFRLGLLLDCPRLavsaRDFICA----HFTLVAKDEDFLGLSADELIAIISSDGLNVEKEEAVFEAVMKWVR 76

                        90       100
                ....*....|....*....|...
gi 33354238 220 HDLEQRKAHLPLLLRNVRLALLP 242
Cdd:cd18477  77 EAKENRQKALPTVFESIRFRLLP 99

NanM

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

284-418

1.11e-15

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

Pssm-ID: 442289 [Multi-domain] Cd Length: 277 Bit Score: 77.50 E-value: 1.11e-15

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238 284 TSPFARPRkAGHTLLILGGqtfmcDKIY-----QVDHKAKEIIPKADLPSPRKEFSASAIGCKVYVTGGrgsENGVSKDV 358
Cdd:COG3055 152 LAPLPTPR-DHLAAAVLPD-----GKILviggrNGSGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGG---ESGFSDEV 222

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238 359 WVYDTVHEEWSKAAPMLIARFGHGSAELENCLYVVGGHTSlagifPASPSVSLKQVEKYD 418
Cdd:COG3055 223 EAYDPATNTWTALGELPTPRHGHAAVLTDGKVYVIGGETK-----PGVRTPLVTSAEVYD 277

BTB_POZ_ZBTB19_PATZ1

cd18207

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

23-143

1.12e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349516 [Multi-domain] Cd Length: 128 Bit Score: 73.85 E-value: 1.12e-15

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  23 FHKASHPDCVLAHLNTLRKHC-MFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQDNLHPEVLELL 101
Cdd:cd18207   4 YQVSQHSADMLHNLNQQRKSGgRFCDVLLRVGEESFPAHRAVLAACSEYFESVFSAQEGDGGTPRELEMHTISSKVFGDI 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 33354238 102 LDFAYSSRIVINEENAESLLEAGDMLQFHDVRDAAAEFLEKN 143
Cdd:cd18207  84 LDFAYTSRIVVRLESFPELMTAAKFLLMRSVIDICQEVIKQS 125

BACK_KLHL10

cd18450

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be ...

144-221

1.29e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis.

Pssm-ID: 350525 [Multi-domain] Cd Length: 80 Bit Score: 71.87 E-value: 1.29e-15

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 33354238 144 LSPSNCLGMMVLSDAHQCRRLYEFSCRMSLVHFETV-RQSEDFNSLSRDTLLDLISRDELETEDERVVFEAILQWVKHD 221
Cdd:cd18450   1 LTPENCIGIRKFARYYFCPELERKAYRYILRNFEEVaKDSEEFLELSCEELEDIIEDDELNVKEEEVVFEAIVKWIDHD 79

BTB_POZ_ZBTB7A

cd18326

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-141

1.77e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349635 [Multi-domain] Cd Length: 120 Bit Score: 73.05 E-value: 1.77e-15

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  28 HPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFqDNLHPEVLELLLDFAYS 107
Cdd:cd18326   8 HSSDILSSLNEQRTQGLLCDVVILVEGREFPTHRSVLAACSQYFKKLFTSGAVVDQQNVYEI-DFVSAEALTALLDFAYT 86

                        90       100       110
                ....*....|....*....|....*....|....
gi 33354238 108 SRIVINEENAESLLEAGDMLQFHDVRDAAAEFLE 141
Cdd:cd18326  87 ATLTVSTSNVGDILSAARLLEIPAVSHVCADLLD 120

BTB_POZ_BTBD9

cd18287

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

45-122

2.26e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349596 [Multi-domain] Cd Length: 119 Bit Score: 72.65 E-value: 2.26e-15

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 33354238  45 FTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQDnLHPEVLELLLDFAYSSRIVINEENAESLLE 122
Cdd:cd18287  22 YSDVTFVVEEKRFPAHRVILAARSEYFRALLYGGMRESQQSEIELKD-TNAEAFKALLKYIYTGRLTLTDLKEDVLLD 98

BACK_KLHL6

cd18446

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a ...

144-241

2.31e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation.

Pssm-ID: 350521 [Multi-domain] Cd Length: 108 Bit Score: 72.12 E-value: 2.31e-15

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238 144 LSPSNCLGMMVLSDAHQCRRLYEFSCRMSLVHFETVRQSEDFNSLSRDTLLDLISRDELETEDERVVFEAILQWVKHDLE 223
Cdd:cd18446   1 LHPENCVGILRLADAHSLESLKKQVQNYIIQNFSQVLNHEEFLELPVDILCHILKSDDLYVTEEEQVFETVMRWVRYKES 80

                        90
                ....*....|....*...
gi 33354238 224 QRKAHLPLLLRNVRLALL 241
Cdd:cd18446  81 ERLPLLPRVLENVRLPLL 98

BTB_POZ

cd01165

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

48-127

2.43e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.

Pssm-ID: 349496 [Multi-domain] Cd Length: 79 Bit Score: 71.16 E-value: 2.43e-15

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  48 VTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFqDNLHPEVLELLLDFAYSSRIVINEENAESLLEAGDML 127
Cdd:cd01165   1 VVLVVEGEKFHVNKELLAQSSEYFRALFRGGFRESGQAEINL-RDISPEDFRALLEFLYGGKRDLDASNLLELLEAANFL 79

BTB_POZ_roadkill-like

cd18345

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

29-148

2.44e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349654 [Multi-domain] Cd Length: 121 Bit Score: 72.57 E-value: 2.44e-15

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  29 PDCVLAH-LNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQDNLHpEVLELLLDFAYS 107
Cdd:cd18345   1 PECRLSDdLGLLFERSAFSDVTLCVGGREFQAHKAILAARSPVFNAMFEHEMEERKQNRVEITDVDH-EVMREMLRFIYT 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 33354238 108 SRIVINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLSPSN 148
Cdd:cd18345  80 GKAPNLDKMADDLLAAADKYALERLKVMCEEALCSNLSVEN 120

BTB_POZ_ZBTB7

cd18198

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-141

4.54e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349507 [Multi-domain] Cd Length: 120 Bit Score: 71.82 E-value: 4.54e-15

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  28 HPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFqDNLHPEVLELLLDFAYS 107
Cdd:cd18198   8 HSSEILSGLNEQRTQGLLCDVVILVQGREYRTHRSVLAACSQYFKKLFTSGAVVDQQNVYEI-DFVSPEALTALLEFAYT 86

                        90       100       110
                ....*....|....*....|....*....|....
gi 33354238 108 SRIVINEENAESLLEAGDMLQFHDVRDAAAEFLE 141
Cdd:cd18198  87 ATLTVSTANVGDILSAARLLEIPCVSHVCAEILD 120

BACK_KLHL40_KBTBD5

cd18516

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also ...

144-242

4.55e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5, or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy.

Pssm-ID: 350591 [Multi-domain] Cd Length: 99 Bit Score: 70.94 E-value: 4.55e-15

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238 144 LSPSNCLGMMVLSDAHQCRRL----YEFSCRmslvHFETVRQSEDFNSLSRDTLLDLISRDELETEDERVVFEAILQWVK 219
Cdd:cd18516   1 LCLSNCLAIFRLGLLLDCPRLavaaRDFICD----RFQLIARDEDFLQLSPDELIAIISSDSLNVEKEEDVFEAVMKWVG 76

                        90       100
                ....*....|....*....|...
gi 33354238 220 HDLEQRKAHLPLLLRNVRLALLP 242
Cdd:cd18516  77 KDQEERTKALPVLLESIRFRLMP 99

BTB_POZ_ZBTB7B_ZBTB15

cd18327

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-141

4.73e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349636 [Multi-domain] Cd Length: 127 Bit Score: 71.80 E-value: 4.73e-15

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  28 HPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQ------DNLHPEVLELL 101
Cdd:cd18327   8 HSSELLSCLNEQRRAGLLCDLTIKTRGLEYRTHRAVLAACSLYFRKLFTGGGGGSGDLGAGGGqdvcelDFVGPEALGAL 87

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 33354238 102 LDFAYSSRIVINEENAESLLEAGDMLQFHDVRDAAAEFLE 141
Cdd:cd18327  88 LEFAYTATLTISSSNMREVLRAARLLEIPCVADACADILQ 127

BTB_POZ_ZBTB24_ZNF450

cd18212

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

24-139

9.65e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349521 [Multi-domain] Cd Length: 118 Bit Score: 70.59 E-value: 9.65e-15

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  24 HKASHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHglRESRDDTVNFQDNLHPEVLELLLD 103
Cdd:cd18212   2 HSKTHKDTVLTNFEEQRKKDFLCDITLIVENVQFRAHKALLAASSEYFSMMFAD--EGEVGQSIYMLEGMVAETFGALLE 79

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 33354238 104 FAYSSRIVINEENAESLLEAGDMLQFHDVRDAAAEF 139
Cdd:cd18212  80 FIYTGCLQVGEKSLEQILATAQFLKVNDLVKAYSDY 115

BTB_POZ_trishanku-like

cd18314

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...

45-133

9.72e-15

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349623 [Multi-domain] Cd Length: 96 Bit Score: 70.07 E-value: 9.72e-15

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  45 FTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQDnLHPEVLELLLDFAYSSRIVINEENAESLLEAG 124
Cdd:cd18314   6 FSDVVLCVGDRKFFAHRIVLCARSPVFRSMLTGSMIESNLKEVTLED-VEPEIFETVLKYMYTGQVTLSEENVLDLLMLA 84


                ....*....
gi 33354238 125 DMLQFHDVR 133
Cdd:cd18314  85 SKYQVPDLE 93

BACK_KLHL23

cd18462

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is ...

148-240

1.59e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is involved in tumorigenesis and resistance to anticancer drug treatment. It also associates with cone-rod dystrophy.

Pssm-ID: 350537 [Multi-domain] Cd Length: 102 Bit Score: 69.76 E-value: 1.59e-14

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238 148 NCLGMMVLSDAHQCRRLYEFSCRMSLVHFETVRQSEDFNSLSRDTLLDLISRDELETEDERVVFEAILQWVKHDLEQRKA 227
Cdd:cd18462   5 NCLGMHSFAEFHVCPELEKESRRIILSRFEEVWQQEEFLELSKEKLLYILSRENLNVWKEEVLIEAVVKWVAHDVEKRIE 84

                        90
                ....*....|...
gi 33354238 228 HLPLLLRNVRLAL 240
Cdd:cd18462  85 CAYDLLSSIKLDL 97

BACK_KLHL41_KBTBD10

cd18517

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also ...

144-242

2.12e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also called Kel-like protein 23, or Kelch repeat and BTB domain-containing protein 10, or Kelch-related protein 1 (Krp1), or sarcosine, is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils.

Pssm-ID: 350592 [Multi-domain] Cd Length: 99 Bit Score: 69.03 E-value: 2.12e-14

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238 144 LSPSNCLGMMVLSDAHQCRRL----YEFSCRmslvHFETVRQSEDFNSLSRDTLLDLISRDELETEDERVVFEAILQWVK 219
Cdd:cd18517   1 LSVGNCLAIFRLGLLLDCPRLavsaRDFVSD----RFEQISKEEDFLQLAPHELIAIISSDSLNVEKEELVFEAVMKWVR 76

                        90       100
                ....*....|....*....|...
gi 33354238 220 HDLEQRKAHLPLLLRNVRLALLP 242
Cdd:cd18517  77 TDKENRVKSLGEIFDCIRFRLMP 99

BACK_KBTBD2

cd18479

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...

144-238

4.90e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulating the insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation.

Pssm-ID: 350554 [Multi-domain] Cd Length: 96 Bit Score: 68.16 E-value: 4.90e-14

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238 144 LSPSNCLGMMVLSDAHQCRRLYEFSCRMSLVHFETVRQSEDFNSLSRDTLLDLISRDELETEDERVVFEAILQWVKHDLE 223
Cdd:cd18479   1 INAENCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYHQEAFMQLSHDLLIDILSSDNLNVEKEETVREAAMLWLEYNTE 80

                        90
                ....*....|....*
gi 33354238 224 QRKAHLPLLLRNVRL 238
Cdd:cd18479  81 SRSQYLSSVLSQIRI 95

BTB2_POZ_KLHL33

cd18263

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

47-150

5.48e-14

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349572 [Multi-domain] Cd Length: 118 Bit Score: 68.69 E-value: 5.48e-14

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  47 DVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQdNLHPEVLELLLDFAYSSRIVINEENAESLLEAGDM 126
Cdd:cd18263  15 DVQLEADGSIFRVHRVILAAGSDYFRAMFTSGMKESTQSVVQLP-TIPAKDLRLLISFAYSGILHLSWENLFEATCTALQ 93

                        90       100
                ....*....|....*....|....
gi 33354238 127 LQFHDVRDAAAEFLEKNLSPSNCL 150
Cdd:cd18263  94 LQISGALALCLDFLQREISPARCL 117

BTB_POZ_ZBTB27-like

cd18215

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-139

6.86e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349524 [Multi-domain] Cd Length: 113 Bit Score: 67.98 E-value: 6.86e-14

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  28 HPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRdDTVNFQDNLHPEVLELLLDFAYS 107
Cdd:cd18215   2 HASDVLLNLNRLRSRDILTDVVLVVGREQFRAHKTVLMACSGLFYSIFTDQLKNNV-SVINLDPEIEPEGFRILLDFMYT 80

                        90       100       110
                ....*....|....*....|....*....|..
gi 33354238 108 SRIVINEENAESLLEAGDMLQFHDVRDAAAEF 139
Cdd:cd18215  81 SRLNLREGNIMAVMATAMYLQMEHVVDTCRKF 112

BTB_POZ_BAB-like

cd18315

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...

45-128

8.97e-14

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349624 [Multi-domain] Cd Length: 85 Bit Score: 66.80 E-value: 8.97e-14

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  45 FTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHglRESRDDTVNFQDNLHPEVLELLLDFAYSSRIVINEENAESLLEAG 124
Cdd:cd18315   1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKE--TPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLA 78


                ....
gi 33354238 125 DMLQ 128
Cdd:cd18315  79 ELLQ 82

BTB_POZ_KBTBD4

cd18272

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

44-153

1.00e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349581 [Multi-domain] Cd Length: 140 Bit Score: 68.38 E-value: 1.00e-13

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  44 MFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQDnLHPEVLELLLDFAYSSRIVINEENAESLLEA 123
Cdd:cd18272  31 LFADVTISVEGKEFQLHRLVLSAQSCFFRSMFTSNLKEARNRVIELKD-VSESVFQLLVDYIYHGTVKLRVEELQETYEV 109

                        90       100       110
                ....*....|....*....|....*....|
gi 33354238 124 GDMLQFHDVRDAAAEFLEKNLSPSNCLGMM 153
Cdd:cd18272 110 ADMYQLTALFEECSRFLARTVQVRNCLQVM 139

BTB_POZ_ZBTB7C_ZBTB36

cd18328

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

27-141

1.87e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349637 [Multi-domain] Cd Length: 120 Bit Score: 67.21 E-value: 1.87e-13

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  27 SHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFqDNLHPEVLELLLDFAY 106
Cdd:cd18328   7 NHSSEVLCSLNEQRHDGLLCDVVLIVQDQEYRTHRSVLAACSKYFKKLFTAGTLADQPYVYEI-DFVTPEALSAILEFAY 85

                        90       100       110
                ....*....|....*....|....*....|....*
gi 33354238 107 SSRIVINEENAESLLEAGDMLQFHDVRDAAAEFLE 141
Cdd:cd18328  86 TSTLTITTSNVKHILNAAQMLEIQCIINVCLEIMD 120

BACK_KBTBD3

cd18480

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...

147-225

1.95e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also termed BTB and kelch domain-containing protein 3 (BKLHD3), is a BTB-Kelch family protein. Its function remains unclear.

Pssm-ID: 350555 [Multi-domain] Cd Length: 82 Bit Score: 65.81 E-value: 1.95e-13

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 33354238 147 SNCLGMMVLSDAHQCRRLYEFSCRMSLVHFETVRQSEDFNSLSRDTLLDLISRDELETEDERVVFEAILQWVKHDLEQR 225
Cdd:cd18480   4 SNCLQLLSFAESYGSTRLLDHALEFVMQHFSLLSQSQEFLELNFEVLEKILEADELNVPDEEAVLKAVLRWTKHDLEAR 82

BTB_POZ_ZBTB28_BCL6B

cd18332

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-141

2.45e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349641 [Multi-domain] Cd Length: 114 Bit Score: 66.42 E-value: 2.45e-13

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  28 HPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRdDTVNFQDNLHPEVLELLLDFAYS 107
Cdd:cd18332   2 HSSDVLLNLNELRKRDILTDVTLLVGGTPLRAHKAVLIACSGFFYSIFSGRVGEGV-SVLTLPSGLEARGFQLLLDFMYT 80

                        90       100       110
                ....*....|....*....|....*....|....
gi 33354238 108 SRIVINEENAESLLEAGDMLQFHDVRDAAAEFLE 141
Cdd:cd18332  81 SRLPLTPRTVPAVLAAATYLQMEHVVETCRRFIQ 114

BTB_POZ_ZBTB4

cd18195

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-112

3.74e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4); ZBTB4, also called KAISO-like zinc finger protein 1 (KAISO-L1), is a transcriptional repressor with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. ZBTB4 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349504 [Multi-domain] Cd Length: 124 Bit Score: 66.45 E-value: 3.74e-13

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  28 HPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSH--GLRESRDDTVNFQDNLHPEVLEL----- 100
Cdd:cd18195   1 HAGALLLQLNEQRLRGLFCDVTLIAGDTKFRAHRSVLAASSPYFRELLSSplPLGAAAVAAAPGATQSPERVLELpgvka 80

                        90
                ....*....|....*..
gi 33354238 101 -----LLDFAYSSRIVI 112
Cdd:cd18195  81 gvfsdVLNFIYSSRVAL 97

BTB_POZ_BACH

cd18955

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

47-140

3.88e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349736 [Multi-domain] Cd Length: 94 Bit Score: 65.18 E-value: 3.88e-13

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  47 DVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLREsrDDTVNFQDNLHPEVLELLLDFAYSSRIVINEENAESLLEAGDM 126
Cdd:cd18955   3 DVTIVVEDQRFRAHRAVLAACSDYFLSRVVGQTDG--DLVITLPEEVTVKGFEPLLQFAYTAKLLLSKENVLEVCRCAEF 80

                        90
                ....*....|....
gi 33354238 127 LQFHDVRDAAAEFL 140
Cdd:cd18955  81 LGVHNIEKACFDFL 94

BACK_KLHL35

cd18474

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs ...

144-221

5.30e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs to the KLHL family. Its function remains unclear. Hypermethylation of KLHL35 is associated with hepatocellular carcinoma and abdominal aortic aneurysm.

Pssm-ID: 350549 [Multi-domain] Cd Length: 79 Bit Score: 64.45 E-value: 5.30e-13

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 33354238 144 LSPSNCLGMMVLSDAHQCRRLYEFSCRMSLVHFETVRQSEDFNSLSRDTLLDLISRDELETEDERVVFEAILQWVKHD 221
Cdd:cd18474   1 IGANNCLALLAAADALHCAPLQEHCIRVLLRDFAQAARHPSFLKLELQLVLELLADDSLAVRSEEVVLEAALRWVDAD 78

BTB_POZ_ZBTB46

cd18230

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

27-147

5.66e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349539 [Multi-domain] Cd Length: 125 Bit Score: 65.85 E-value: 5.66e-13

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  27 SHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQDNLHPEVLELLLDFAY 106
Cdd:cd18230   3 SHYRHLLRELNEQRQHGILCDVCIIVEGKIFKAHKNVLLGSSRYFKTLYCQVQKTSDQATVTHLDIVTAQGFKAIIDFMY 82

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 33354238 107 SSRIVINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLSPS 147
Cdd:cd18230  83 SAHLALTSKNVIEVMSAASYLQMTDIVQACHNFIKAALDIS 123

BTB2_POZ_BTBD8

cd18286

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

46-144

8.33e-13

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349595 [Multi-domain] Cd Length: 121 Bit Score: 65.36 E-value: 8.33e-13

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  46 TDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQDNlHPEVLELLLDFAYSSRIVI-NEENAESLLEAG 124
Cdd:cd18286  18 SDITIKVDGKTFKAHRCILCARSSYFAAMLSGSWAESNSSEITLTGV-SHAAVSFVLLFIYGGVLDLpDDVNLGELLSLA 96

                        90       100
                ....*....|....*....|
gi 33354238 125 DMLQFHDVRDAAAEFLEKNL 144
Cdd:cd18286  97 DMYGLDGLKDVVAYTLRRDY 116

BTB_POZ_BACH1

cd18277

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

23-140

8.64e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349586 [Multi-domain] Cd Length: 120 Bit Score: 65.09 E-value: 8.64e-13

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  23 FHKASHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHglRESRDDTVNFQDNLHPEVLELLL 102
Cdd:cd18277   5 YESSVHSTNVLLSLNDQRKKDVLCDVTILVEGQRFRAHRSVLAACSSYFHSRIVG--QADAELNITLPEEVTVKGFEPLI 82

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 33354238 103 DFAYSSRIVINEENAESLLEAGDMLQFHDVRDAAAEFL 140
Cdd:cd18277  83 QFAYTAKLILSKDNVDEVCKCVEFLSVHNIEESCFQFL 120

BTB_POZ_KLHL22

cd18251

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

23-140

1.09e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349560 [Multi-domain] Cd Length: 125 Bit Score: 65.23 E-value: 1.09e-12

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  23 FHKASHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQDNLHPEVLElLL 102
Cdd:cd18251   1 YRSVAHSQALLDGLVALRDSGILFDVVLVVEGKPIEAHRILLAASCDYFRGMFAGGLREMQQTEVLIHGVSYNAMCK-IL 79

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 33354238 103 DFAYSSRIVINEENAESLLEAGDMLQFHDVRDAAAEFL 140
Cdd:cd18251  80 DFIYTSELELSLDNVQETLTAACQLQIPEVIGFCCDFL 117

BTB_POZ_ZBTB8B

cd18330

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

32-132

1.65e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349639 [Multi-domain] Cd Length: 113 Bit Score: 64.18 E-value: 1.65e-12

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  32 VLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQDNLHPEVLELLLDFAYSSRIV 111
Cdd:cd18330   5 LLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALLIHYIQDSGRHSTASLDIVTSEAFSIILDFLYSGKLD 84

                        90       100
                ....*....|....*....|.
gi 33354238 112 INEENAESLLEAGDMLQFHDV 132
Cdd:cd18330  85 LCSENVIEVMSAASYLQMTDV 105

BACK_KBTBD8

cd18483

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...

144-230

2.50e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor for a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralogue TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome.

Pssm-ID: 350558 [Multi-domain] Cd Length: 97 Bit Score: 63.34 E-value: 2.50e-12

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238 144 LSPSNCLGMMVLSDAHQCRRLYEFSCRMSLVHFETVRQSEDFNSLSRDTLLDLISRDELETEDERVVFEAILQWVKHDLE 223
Cdd:cd18483   1 LDPQNSIGVFIFADHYGHQELKERSQDYIRKKFLSVTKEQEFLHLTKDQLISILNSDDLNVEKEEHVYESIIHWFEHEQS 80


                ....*..
gi 33354238 224 QRKAHLP 230
Cdd:cd18483  81 KREMHLP 87

BTB_POZ_BTBD14B_NAC1

cd18290

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

32-142

2.53e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349599 [Multi-domain] Cd Length: 123 Bit Score: 63.90 E-value: 2.53e-12

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  32 VLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFShglrESRDDTVNFQDNLHPEVLELLLDFAYSSRIV 111
Cdd:cd18290  14 ILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFN----SSRSAVVELPAAVQPQSFQQILSFCYTGRLS 89

                        90       100       110
                ....*....|....*....|....*....|.
gi 33354238 112 INEENAESLLEAGDMLQFHDVRDAAAEFLEK 142
Cdd:cd18290  90 MNVGDQFLLMYTAGFLQIQEIMEKGTEFFLK 120

BACK_KLHL33

cd18472

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs ...

144-218

3.40e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs to the KLHL family. Its function remains unclear. KLHL33 SNPs may be associated with prostate cancer risk.

Pssm-ID: 350547 [Multi-domain] Cd Length: 75 Bit Score: 62.02 E-value: 3.40e-12

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 33354238 144 LSPSNCLGMMVLSDAHQCRRLYEFSCRMSLVHFETVRQSEDFNSLSRDTLLDLISRDELETEDERVVFEAILQWV 218
Cdd:cd18472   1 LSPANCLELWAFADAATLPRLAAAARAFALKHFAEVAASAAFLSLPLARLLELLRSDELEVAEEEAVFEAAVRWL 75

BTB_POZ_SPOP

cd18342

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

29-148

5.91e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349651 [Multi-domain] Cd Length: 125 Bit Score: 63.20 E-value: 5.91e-12

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  29 PDCVLA-HLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQDnLHPEVLELLLDFAYS 107
Cdd:cd18342   5 PECRLAdELGGLWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEIND-VEPEVFKEMMCFIYT 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 33354238 108 SRIVINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLSPSN 148
Cdd:cd18342  84 GKAPNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVEN 124

BTB_POZ_ZBTB10

cd18201

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

32-145

8.77e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349510 [Multi-domain] Cd Length: 122 Bit Score: 62.28 E-value: 8.77e-12

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  32 VLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDD-TVNFQDNLHPEVLELLLDFAYSSRI 110
Cdd:cd18201   8 LLQELNEQRKKGILCDVNIVVSGKVFRAHKNILVAGSRFFKTLYCFTNKESCDQtTVTHLDVVAVQGFSVILDFMYSGNL 87

                        90       100       110
                ....*....|....*....|....*....|....*
gi 33354238 111 VINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLS 145
Cdd:cd18201  88 VLTSQNAIEVMSVASYLQMTEVVQSCRNFIKDALN 122

BTB_POZ_ZBTB38_CIBZ

cd18223

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-148

9.52e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349532 [Multi-domain] Cd Length: 114 Bit Score: 62.11 E-value: 9.52e-12

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  28 HPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMF-SHGLRESrdDTVNFQDNLHPEVLELLLDFAY 106
Cdd:cd18223   1 HSDTVLSCLNEQRIQGILCDVTIVVEDTKFKAHKNVLAASSLYFKNAFsSQEIWIS--SHVLELPDLKAEVFAEILNFIY 78

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 33354238 107 SSRIVINE-ENAESLLEAGDMLqfhdvrdaAAEFLEkNLSPSN 148
Cdd:cd18223  79 SSKVVVKRqETVTDLVAAGKKL--------GITFLE-NLTDQN 112

BACK_KBTBD12

cd18485

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...

144-240

1.05e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also termed Kelch domain-containing protein 6 (KLHDC6), is a BTB-Kelch family protein. Its function remains unclear.

Pssm-ID: 350560 [Multi-domain] Cd Length: 100 Bit Score: 61.67 E-value: 1.05e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238 144 LSPSNCLGMMVLSD-------AHQCRR-LYEfscrmslvHFETVRQSEDFNSLSRDTLLDLISRDELETEDERVVFEAIL 215
Cdd:cd18485   1 MDASNCLGIYYFAKqigaedlSDRARKyLYQ--------HFTEVCLHEEVLEIEAHQLLTLIKSDDLNVSREESILDLVL 72

                        90       100
                ....*....|....*....|....*
gi 33354238 216 QWVKHDLEQRKAHLPLLLRNVRLAL 240
Cdd:cd18485  73 RWVNHNRKSRVQHLVELLKQVRLEL 97

BTB_POZ_BACH2

cd18278

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

22-140

1.48e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349587 [Multi-domain] Cd Length: 124 Bit Score: 61.89 E-value: 1.48e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  22 VFHKASHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHglRESRDDTVNFQDNLHPEVLELL 101
Cdd:cd18278   8 VYESTVHCTNILLCLNDQRKQDILCDVTLIVEGKEFRAHRAVLAACSEYFLQALVG--QTENDLVVSLPEEVTARGFGPL 85

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 33354238 102 LDFAYSSRIVINEENAESLLEAGDMLQFHDVRDAAAEFL 140
Cdd:cd18278  86 LQFAYTAKLLLSRENIQEVIRCAEFLRMHNLEDSCFRFL 124

BACK

cd14733

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...

145-199

1.66e-11

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.

Pssm-ID: 350515 [Multi-domain] Cd Length: 55 Bit Score: 59.60 E-value: 1.66e-11

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 33354238 145 SPSNCLGMMVLSDAHQCRRLYEFSCRMSLVHFETVRQSEDFNSLSRDTLLDLISR 199
Cdd:cd14733   1 DPENCLGILELADLYNLEELKEKALKFILENFEEVSKSEEFLELSVELLLELLSS 55

BTB_POZ_ZBTB37

cd18222

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

30-141

1.95e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37); ZBTB37 may be involved in transcriptional regulation. It is differentially expressed in aryl hydrocarbon receptor (AhR)-KO mice compared with WT mice, and may potentially contribute to the aging phenotype of AhR-KO mice. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349531 [Multi-domain] Cd Length: 123 Bit Score: 61.60 E-value: 1.95e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  30 DCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFShgLRESRDDTVNFQDNlhPEVLELLLDFAYSSR 109
Cdd:cd18222  10 NSVLSHLNQLRMQGRLCDIVVNVQGQSFRAHKVVLAASSPYFRDHMS--LNEMSTVSISVIKN--PTVFEQLLSFCYTGR 85

                        90       100       110
                ....*....|....*....|....*....|..
gi 33354238 110 IVINEENAESLLEAGDMLQFHDVRDAAAEFLE 141
Cdd:cd18222  86 ICLQLADIISYLTAASFLQMQHIIDKCTQILE 117

BTB_POZ_KLHL15

cd18244

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

19-153

1.98e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349553 [Multi-domain] Cd Length: 137 Bit Score: 61.90 E-value: 1.98e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  19 NISVFHKASHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQdNLHPEVL 98
Cdd:cd18244   4 DVEVYNSSIHDTSVSAGFRALYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQDKIHLK-GLTATGF 82

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 33354238  99 ELLLDFAYSSRIVINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLSPSNCLGMM 153
Cdd:cd18244  83 SHVLQFMYYGTIELSMLTVHEILQAAMYVQLTEVVKFCCSFLLAKICLDNCAEIM 137

BTB_POZ_ARIA_plant

cd18352

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...

46-125

2.89e-11

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349661 [Multi-domain] Cd Length: 116 Bit Score: 60.57 E-value: 2.89e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  46 TDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQdNLHPEVLELLLDFAYSSRIVINEENAESLLEAGD 125
Cdd:cd18352  14 SDVTFLVEGRRFYAHRIALLASSDAFRAMFDGGYREKEARDIEIP-NIRWEVFELMMRFIYTGSVDITNDIAKDLLRAAD 92

BTB_POZ_ZBTB1

cd18192

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

25-134

3.26e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 1 (ZBTB1); ZBTB1 acts as a transcriptional repressor that represses cAMP-responsive element (CRE)-mediated transcriptional activation. It also has a role in translesion DNA synthesis, and is essential for lymphocyte development. ZBTB1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349501 [Multi-domain] Cd Length: 114 Bit Score: 60.60 E-value: 3.26e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  25 KASHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMF-SHGLRESRDDTVNFQdnLHPEVLELLLD 103
Cdd:cd18192   1 RPSHSSYVLQQLNNQREWGFLCDCCIAIDDIYFQAHKAVLAACSSYFRMMFiNHQHTTAQLNLSNMK--ISAECFDLILQ 78

                        90       100       110
                ....*....|....*....|....*....|.
gi 33354238 104 FAYSSRIVINEENAESLLEAGDMLQFHDVRD 134
Cdd:cd18192  79 FMYLGKIMTAPSDFEQLKVAMNYLQLYYIPE 109

Kelch

Kelch domain;

389-441

3.31e-11

Kelch domain;

Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 58.34 E-value: 3.31e-11

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 33354238    389 CLYVVGGHtslagifpaSPSVSLKQVEKYDPGDNKWTMVAPMRDGVSNAAVVS 441
Cdd:smart00612   1 KIYVVGGF---------DGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAV 44

BTB_POZ_calicin

cd18307

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

45-139

3.64e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa. It contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349616 [Multi-domain] Cd Length: 97 Bit Score: 59.82 E-value: 3.64e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  45 FTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDD---TVNFqDNLHPEVLELLLDFAYSSRIVINEENAESLL 121
Cdd:cd18307   1 FCDVVISVDNHSFAAHRNVLAAVSPFVKSLISSNDMKATDElsiTIDC-DYLSPETVEQLLDYFYTGKIVISEKNVEDLL 79

                        90
                ....*....|....*...
gi 33354238 122 EAGDMLQFHDVRDAAAEF 139
Cdd:cd18307  80 KGAKYFNIPRLKDHCVDF 97

BTB_POZ_ZBTB39

cd18224

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

24-135

3.74e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 39 (ZBTB39); ZBTB39 may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349533 [Multi-domain] Cd Length: 123 Bit Score: 60.62 E-value: 3.74e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  24 HKASHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSH-GLRESRDDTVNFqdnLHPEVLELLL 102
Cdd:cd18224   5 HSSDHPNNLLKELNKCRLSETMCDVTIVVGNRSFAAHKAVLACAAGYFQKLFLStELDVARTYVVDF---ITPANFEKVL 81

                        90       100       110
                ....*....|....*....|....*....|...
gi 33354238 103 DFAYSSRIVINEENAESLLEAGDMLQFHDVRDA 135
Cdd:cd18224  82 SFIYTSELFTDLINVGVIYEVAEKLGMEDLLKA 114

BTB_POZ_ZBTB30_HIC2

cd18334

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

27-143

4.27e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349643 [Multi-domain] Cd Length: 120 Bit Score: 60.37 E-value: 4.27e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  27 SHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHglresrDDTVNFQ-DNLHPEVLELLLDFA 105
Cdd:cd18334   3 NHAKQLLLQLNQQRAKGFLCDVIIVVENALFRAHKNILAASSMYFKSLVLH------DNLINLDtDMVNPTVFRQILDFI 76

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 33354238 106 YSSRIVIN----EENAESLLEAGDMLQFHDVRDAAAEFLEKN 143
Cdd:cd18334  77 YTGKLLTSdqpgEQNFNALLTAASYLQLHDLAALCRKKLKRN 118

BTB_POZ_ZBTB31_myoneurin

cd18217

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-132

8.69e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349526 [Multi-domain] Cd Length: 111 Bit Score: 59.38 E-value: 8.69e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  28 HPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFshglrESRDDTVNF--QDNLHPEVLELLLDFA 105
Cdd:cd18217   1 HCEQLLERLNKQREAGFLCDCTIVIGQFQFKAHRNVLAAFSEYFGAQY-----KDTEDNIVFldQSQVSADGFQKLLEFI 75

                        90       100
                ....*....|....*....|....*..
gi 33354238 106 YSSRIVINEENAESLLEAGDMLQFHDV 132
Cdd:cd18217  76 YTGNLNLDSWNVAEIHQAASYLGMEEV 102

BTB_POZ_ZBTB21_ZNF295

cd18209

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-124

8.96e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21); ZBTB21, also called zinc finger protein 295 (ZNF295), is a transcription repressor that acts in a selective manner on different promoters. It may be involved in the bi-directional control of gene expression in concert with another transcription factor ZFP161. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349518 [Multi-domain] Cd Length: 112 Bit Score: 59.12 E-value: 8.96e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  28 HPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHglRESRDDTVNFQDNLHPEVLELLLDFAYS 107
Cdd:cd18209   1 HAISLLSALNEERLKGQLCDVLLIVGDQKFRAHKNVLAASSEYFQSLFTE--KENESQSVFQLDFCEPDAFENVLNYIYS 78

                        90
                ....*....|....*..
gi 33354238 108 SRIVINEENAESLLEAG 124
Cdd:cd18209  79 SSLFVEKSSLAAVQELG 95

BTB_POZ_ZBTB27_BCL6

cd18331

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-140

9.72e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349640 [Multi-domain] Cd Length: 118 Bit Score: 59.49 E-value: 9.72e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  28 HPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRdDTVNFQDNLHPEVLELLLDFAYS 107
Cdd:cd18331   7 HASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSIFTDQLKCNL-SVINLDPEINPEGFNILLDFMYT 85

                        90       100       110
                ....*....|....*....|....*....|...
gi 33354238 108 SRIVINEENAESLLEAGDMLQFHDVRDAAAEFL 140
Cdd:cd18331  86 SRLNLREGNIMAVMATAMYLQMEHVVDTCRKFI 118

PHA02713

hypothetical protein; Provisional

32-566

1.05e-10

hypothetical protein; Provisional

Pssm-ID: 165086 [Multi-domain] Cd Length: 557 Bit Score: 64.26 E-value: 1.05e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238   32 VLAHLNTLRKHCMFTDVTLWAGD-RAFPCHRAVLAASSRYFEAMFSHGLReSRD--DTVNFQdNLHPEVLELLLDFAYSS 108
Cdd:PHA02713  12 VVSNISNLLDDDILCDVIITIGDgEEIKAHKTILAAGSKYFRTLFTTPMI-IRDlvTRVNLQ-MFDKDAVKNIVQYLYNR 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  109 RIviNEENAESLLEAGDMLQFHDVRDAAAEFLEKNLSPSNCLGMMvlsdahqcRRLYEFSC--------RMSLVHFETVR 180
Cdd:PHA02713  90 HI--SSMNVIDVLKCADYLLIDDLVTDCESYIKDYTNHDTCIYMY--------HRLYEMSHipivkyikRMLMSNIPTLI 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  181 QSEDFNSLSRDTLLDLISRDE---LETEDERVVFeaILQWVKHDLEQRKAHLPLL----LRNV----RLALLpsdclkna 249
Cdd:PHA02713 160 TTDAFKKTVFEILFDIISTNDnvyLYREGYKVTI--LLKWLEYNYITEEQLLCILscidIQNLdkksRLLLY-------- 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  250 vSGEALLMADECTKLILDEAfrcktkilLNDGVVtspfarPRKaghtLLILGGQTFM-----CDKIYQVDHKAKEIIpkA 324
Cdd:PHA02713 230 -SNKTINMYPSCIQFLLDNK--------QNRNII------PRQ----LCLVCHDTKYnvcnpCILVYNINTMEYSVI--S 288

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  325 DLPSPRKEFSASAIGCKVYVTGGRGSENGVSKDVWVYDTVHEEWSKAAPMLIARFGHGSAELENCLYVVGGHTSlagifp 404
Cdd:PHA02713 289 TIPNHIINYASAIVDNEIIIAGGYNFNNPSLNKVYKINIENKIHVELPPMIKNRCRFSLAVIDDTIYAIGGQNG------ 362

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  405 aspSVSLKQVEKYDPGDNKWTMVAPMRDGVSNAAVVSAKLKLFVFGGTSIHRDMVS-----------------KVQCFDP 467
Cdd:PHA02713 363 ---TNVERTIECYTMGDDKWKMLPDMPIALSSYGMCVLDQYIYIIGGRTEHIDYTSvhhmnsidmeedthssnKVIRYDT 439

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  468 SENRWtikAECPQPWRYTAAAVLGSQ---IFIMGG--DTEYTAASAYRFDCET-NQWTRIGDMTAKRMSCHAVASGNKLY 541
Cdd:PHA02713 440 VNNIW---ETLPNFWTGTIRPGVVSHkddIYVVCDikDEKNVKTCIFRYNTNTyNGWELITTTESRLSALHTILHDNTIM 516

                        570       580
                 ....*....|....*....|....*
gi 33354238  542 VVGGYfgtQRCKTLDCYDPTSDTWN 566
Cdd:PHA02713 517 MLHCY---ESYMLQDTFNVYTYEWN 538

BTB2_POZ_ABTB1_BPOZ1

cd18296

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

42-127

1.26e-10

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349605 [Multi-domain] Cd Length: 121 Bit Score: 59.23 E-value: 1.26e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  42 HCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRD-----DTVNFQDnLHPEVLELLLDFAYSSRIVINEEN 116
Cdd:cd18296  14 ELSFPDVCFQVEGHRFPCHKAFFCGRSDYFKALLRDHFAESEEnngsiPVVTLHD-VSPEVFAIVLYYIYTDDTDLPPEN 92

                        90
                ....*....|.
gi 33354238 117 AESLLEAGDML 127
Cdd:cd18296  93 AYDVLYVADMY 103

BTB_POZ_BTBD19

cd18294

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

44-140

1.67e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349603 [Multi-domain] Cd Length: 111 Bit Score: 58.41 E-value: 1.67e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  44 MFTDVTLWAGDRAFP--CHRAVLAASSRYFEAMFSHGLRESRDDTVNFQDNLHPEVLELLLDFAYSSRIVINEENAESLL 121
Cdd:cd18294  13 EFSDVKFLVGPERQEifAHKCILAARCEVFRAMFLTGPQKESTQSPLVLSDIEPEVFRAVLEFIYTNCVTLSNHTVIEVL 92

                        90
                ....*....|....*....
gi 33354238 122 EAGDMLQFHDVRDAAAEFL 140
Cdd:cd18294  93 AAAVEYGLDELRKLCERFI 111

BTB_POZ_TDPOZ

cd18344

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

29-148

3.73e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349653 [Multi-domain] Cd Length: 128 Bit Score: 58.04 E-value: 3.73e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  29 PDCVLAH-LNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQDnLHPEVLELLLDFAYS 107
Cdd:cd18344   6 PRHMLTDdLGELWENSLFTDCCLLVAGHEFRAHKAILAARSPVFRAMFEHEMEERLKNPIEIHD-LDPQVFKEMMGFIYT 84

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 33354238 108 SRI--VINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLSPSN 148
Cdd:cd18344  85 GKAphLHSHSMACDVLAAADKYGLEGLKVLCEDALCRNLSVEN 127

BTB_POZ_ZBTB17_MIZ1

cd18206

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-139

4.45e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349515 [Multi-domain] Cd Length: 112 Bit Score: 57.25 E-value: 4.45e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  28 HPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFshglresrddtVNFQDNLHPEV-----LELLL 102
Cdd:cd18206   5 HSQHVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFRMLF-----------VDQKDVVHLDIsnaagLGQVL 73

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 33354238 103 DFAYSSRIVINEENAESLLEAGDMLQFHDVRDAAAEF 139
Cdd:cd18206  74 EFMYTAKLSLSPENVDDVLAVATFLQMQDIVTACHAL 110

BTB_POZ_KLHL14_printor

cd18243

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

27-148

4.78e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14); KLHL14 is also called protein interactor of Torsin-1A (TOR1A), protein interactor of torsinA, or Printor. It is a novel torsinA-interacting protein that preferentially interacts with ATP-free form of TOR1A and is implicated in dystonia pathogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349552 [Multi-domain] Cd Length: 130 Bit Score: 57.74 E-value: 4.78e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  27 SHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFShglresrDDTVNFQDNLHPEvLELLLDFAY 106
Cdd:cd18243  14 SHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFS-------INNLVLQGCSSIG-LRLVLEYLY 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 33354238 107 SSRIVINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLSPSN 148
Cdd:cd18243  86 TANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQN 127

BTB2_POZ_IBtk

cd18302

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

41-107

4.95e-10

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349611 [Multi-domain] Cd Length: 113 Bit Score: 56.99 E-value: 4.95e-10

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 33354238  41 KHCMFTDVTLWAGD-RAFPCHRAVLAASSRYFEAMFSHGLRE-SRDDTVNFQdnLHPEVLELLLDFAYS 107
Cdd:cd18302   1 KHSDLYDVTIVSEDgKEFPCHKCVLVARLEYFHSMLSSSWIEaSSCSALTMP--IPSDILEIILDYLYT 67

BTB_POZ_KLHL42

cd18319

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

53-141

6.55e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also called Cullin-3-binding protein 9 (Ctb9) or Kelch domain-containing protein 5, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of katanin (KATNA1). KLHL42 is involved in microtubule dynamics throughout mitosis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349628 [Multi-domain] Cd Length: 93 Bit Score: 56.03 E-value: 6.55e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  53 GDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQdNLHPEVLELLLDFAYSSRIVINEENAESLLEAGDMLQfhDV 132
Cdd:cd18319   9 EDRCYNVSKRKLIEQSDYFRALYRSGMRESGEEVVQLR-GLSAPGLELVLDFINTSKVHESQGDSTDTLEENELLE--DL 85


                ....*....
gi 33354238 133 RDAAAeFLE 141
Cdd:cd18319  86 VEAAS-FLQ 93

BTB_POZ_ZBTB48_TZAP_KR3

cd18232

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-131

7.45e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349541 [Multi-domain] Cd Length: 108 Bit Score: 56.31 E-value: 7.45e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  28 HPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLresrDDTVNFQDNLhPEVLELLLDFAYS 107
Cdd:cd18232   1 HSVKVLQALNKQREEGQYCDATLDVGGRVFKAHWSVLACCSHFFQSLYGDGT----SGSVVLPESF-AEVFGLLLDFFYT 75

                        90       100
                ....*....|....*....|....
gi 33354238 108 SRIVINEENAESLLEAGDMLQFHD 131
Cdd:cd18232  76 GELALTRENRDRVLLAAKELRVPE 99

PLN02193

nitrile-specifier protein

337-521

9.93e-10

nitrile-specifier protein

Pssm-ID: 177844 [Multi-domain] Cd Length: 470 Bit Score: 61.12 E-value: 9.93e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  337 AIGCKVYVTGGRGSE---NGVskdvWVYDTVHEEWSKAAPML---IARFGHGSAELENCLYVVGGhtslagifpASPSVS 410
Cdd:PLN02193 226 SIGSTLYVFGGRDASrqyNGF----YSFDTTTNEWKLLTPVEegpTPRSFHSMAADEENVYVFGG---------VSATAR 292

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  411 LKQVEKYDPGDNKWTMVAPMRD-----GVSNAAVVSAKL-KLFVFGGTSihrdmVSKVQCFDPSENRWT---IKAECPQP 481
Cdd:PLN02193 293 LKTLDSYNIVDKKWFHCSTPGDsfsirGGAGLEVVQGKVwVVYGFNGCE-----VDDVHYYDPVQDKWTqveTFGVRPSE 367

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 33354238  482 WRYTAAAVLGSQIFIMGGDTEYTAAS----------AYRFDCETNQWTRI 521
Cdd:PLN02193 368 RSVFASAAVGKHIVIFGGEIAMDPLAhvgpgqltdgTFALDTETLQWERL 417

BTB2_POZ_LZTR1

cd18309

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

45-148

1.03e-09

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349618 [Multi-domain] Cd Length: 126 Bit Score: 56.63 E-value: 1.03e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  45 FTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLREsrDDTVNFQ-DNLHP--EVLELLLDFAYSSRIVINEENAESLL 121
Cdd:cd18309  20 FCDITLLLDGHPIPAHKAILAARCSYFEAMFRSFMPE--DNTVNISiGEMVPsrQAFDSLLRYIYYGDVTMPPEDSLYLF 97

                        90       100
                ....*....|....*....|....*....
gi 33354238 122 EAGDMLQFHDVRDAAA--EFLEKNLSPSN 148
Cdd:cd18309  98 SAPYFYGFTNNRLQAYckQNLEMNVSFEN 126

BTB1_POZ_KLHL33

cd18262

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

28-127

1.12e-09

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349571 [Multi-domain] Cd Length: 101 Bit Score: 55.68 E-value: 1.12e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  28 HPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFeamfshglRESRDDTVNFQDNLHPEV----LELLLD 103
Cdd:cd18262   1 HPSQFFGEAQRLREQRLLLDETVSVGGRSYGVHSVILAAVSSLF--------RERLLGSNGPLPPLSLEVtpvgWEAVLT 72

                        90       100
                ....*....|....*....|....
gi 33354238 104 FAYSSRIVINEENAESLLEAGDML 127
Cdd:cd18262  73 FAYTGVLGRNPATVGDILVAAEAL 96

BTB_POZ_ZBTB47_ZNF651

cd18231

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

47-140

1.16e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349540 [Multi-domain] Cd Length: 115 Bit Score: 56.08 E-value: 1.16e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  47 DVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVnfQDNLHPEVLELLLDFAYSSRIVINEENAESLLEAGDM 126
Cdd:cd18231  18 DIVLVRQRSTFPAHKGVLAAYSQFFHSLFTQNKQLQRVELS--LEALTSQGLQQILNFIYTSKLLVNSCNVQDVLNAAAV 95

                        90
                ....*....|....
gi 33354238 127 LQFHDVRDAAAEFL 140
Cdd:cd18231  96 LQMNDIAASCQELI 109

BTB_POZ_GCL

cd18305

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

47-143

1.23e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; GCL proteins are nuclear envelope proteins highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in embryos. Both, human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 2 (GMCL2), also called germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L), may function in spermatogenesis. They may also be substrate-specific adaptors of E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. They contain BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349614 [Multi-domain] Cd Length: 115 Bit Score: 56.13 E-value: 1.23e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  47 DVTLWAGDRAFPCHRAVLAASSrYFEAMFSHGLRESRDDTVNFQ---DNLHPEVLELLLDFAYSSRIVINEENAESLLEA 123
Cdd:cd18305  17 DITICALGREWKLHKIYLCQSG-YFASMFSGSWKESKETVINLEipdDNITVEALNVVFGSLYRDEIEIKPSRVVSILAA 95

                        90       100
                ....*....|....*....|
gi 33354238 124 GDMLQFHDVRDAAAEFLEKN 143
Cdd:cd18305  96 ATLLQLDGLIQQCSEVMKET 115

BTB_POZ_ZBTB3-like

cd18194

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-132

1.56e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349503 [Multi-domain] Cd Length: 128 Bit Score: 55.98 E-value: 1.56e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  28 HPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHglRESRDDTVNFQ-DNLHPEVLELLLDFAY 106
Cdd:cd18194   6 HSRQLLQCLREQRSQGFLCDCTVLVGSAQFPAHRAVLASCSMYFHLFYRD--RLDKRDLVRLNsDIVTAPAFGLLLDFMY 83

                        90       100
                ....*....|....*....|....*.
gi 33354238 107 SSRIVINEENAESLLEAGDMLQFHDV 132
Cdd:cd18194  84 EGRLALRDLPVEDVLAAASYLHMYDI 109

Kelch_1

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

528-572

1.72e-09

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.

Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 53.38 E-value: 1.72e-09

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 33354238   528 RMSCHAVASGNKLYVVGGYFGTQRCKTLDCYDPTSDTWNCITTVP 572
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46

BTB_POZ_ZBTB33_KAISO

cd18219

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

26-127

1.93e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kaiso; Kaiso, also called zinc finger and BTB domain-containing protein 33 (ZBTB33), is a DNA methylation-dependent transcriptional repressor that binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3'. It also binds to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349528 [Multi-domain] Cd Length: 106 Bit Score: 55.22 E-value: 1.93e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  26 ASHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGlreSRDDTVNFqdnLHPEVLELLLDFA 105
Cdd:cd18219   2 TQYSGSLLKSLNEQRGHGLFCDVTVIVEDRKFRAHKNILSASSTYFHQLFSVA---GQVVELNF---IRADIFAEILNYI 75

                        90       100
                ....*....|....*....|...
gi 33354238 106 YSSRIV-INEENAESLLEAGDML 127
Cdd:cd18219  76 YSSKIVrVRSDLLEELIKSGQLL 98

BTB_POZ_ETO1-like

cd18190

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...

47-126

2.13e-09

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana ethylene-overproduction protein 1 (ETO1) and similar proteins; ETO1, also called protein ethylene overproducer 1, is an essential regulator of the ethylene pathway, which acts by regulating the stability of 1-aminocyclopropane-1-carboxylate synthase (ACS) enzymes. It may act as a substrate-specific adaptor that connects ACS enzymes, such as ACS5, to ubiquitin ligase complexes, leading to proteasomal degradation of ACS enzymes. The family also includes ETO1-like proteins 1 (EOL1) and 2 (EOL2). ETO1, EOL1, and EOL2 contain a BTB domain and tetratricopeptide (TPR) repeats. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349499 [Multi-domain] Cd Length: 83 Bit Score: 54.44 E-value: 2.13e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  47 DVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQDN-LHPEVLELLLDFAYSSR-IVINEENAESLLEAG 124
Cdd:cd18190   1 DLVFCVGGEKFCCVRKKIASLSRPFKAMLYGNFRESTSDCIDFEENgISIEAMRAVIDFSVTGRlDLFSVENVHEVLELA 80


                ..
gi 33354238 125 DM 126
Cdd:cd18190  81 SK 82

BTB_POZ_ZBTB40

cd18225

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

32-132

2.44e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 40 (ZBTB40); ZBTB40 may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB40 are associated with bone mineral density in European and East-Asian populations. ZBTB40 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349534 [Multi-domain] Cd Length: 116 Bit Score: 55.22 E-value: 2.44e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  32 VLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVnfqdnLHPEVLELLLDFAYSSRIV 111
Cdd:cd18225  10 LLQQLHTLRKEQQFCDCTIFIGTFHFRAHKLVLAASSLLFKSLLDSTDTISIDASV-----VSPEEFALLLEMVYTGKLP 84

                        90       100
                ....*....|....*....|.
gi 33354238 112 INEENAESLLEAGDMLQFHDV 132
Cdd:cd18225  85 PGKHNFTKIISVADSLQMFDV 105

BTB1_POZ_IBtk

cd18301

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

47-108

3.73e-09

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349610 [Multi-domain] Cd Length: 99 Bit Score: 54.22 E-value: 3.73e-09

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 33354238  47 DVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQ---DNLHPEVLELLLDFAYSS 108
Cdd:cd18301  20 DVVFQVGGKTFPAHKFILASRSDYFRKLFLSSLLTSEDAVGCDVvhiEKVPPEIFEQLLQFIYTD 84

BTB_POZ_BTBD17

cd18292

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

44-139

4.19e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349601 [Multi-domain] Cd Length: 114 Bit Score: 54.60 E-value: 4.19e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  44 MFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHglresrDDTVNFQDN---LHPE-----VLELLLDFAYSSRIVINEE 115
Cdd:cd18292  16 ELSDIVLRVGGKVFHAHRLILAKSSDVFRVMLSN------DWWSESKQSeieLVEDpecaaVFEKFLRYLYTGQISVNLE 89

                        90       100
                ....*....|....*....|....
gi 33354238 116 NAESLLEAGDMLQFHDVRDAAAEF 139
Cdd:cd18292  90 TALPLLMLADKYNVTDLKQLCVDF 113

BTB_POZ_BPM_plant

cd18280

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

46-126

4.71e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349589 [Multi-domain] Cd Length: 121 Bit Score: 54.64 E-value: 4.71e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  46 TDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQDnLHPEVLELLLDFAY------------SSRIVIN 113
Cdd:cd18280  15 ADVTFNVDGEKFRAHKLVLAARSPVFRSMLFGPMREENEGEIVIED-VEPPVFKALLHFIYkdelpddvepagSDSSSLD 93

                        90
                ....*....|...
gi 33354238 114 EENAESLLEAGDM 126
Cdd:cd18280  94 TTMAQHLLAAADR 106

BTB_POZ_ZBTB42

cd18956

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-132

4.78e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 42 (ZBTB42); ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. It is enriched in skeletal muscles, especially at the neuromuscular junction. A ZBTB42 mutation has been identified to define a novel lethal congenital contracture syndrome (LCCS6), a lethal autosomal recessive form of arthrogryposis multiplex congenita (AMC). ZBTB42 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349737 [Multi-domain] Cd Length: 129 Bit Score: 54.82 E-value: 4.78e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  28 HPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQDNLHPEVLELLLDFAYS 107
Cdd:cd18956   6 HGGRLLGRLRQQRELGFLCDCTVLVGDARFPAHRAVLAACSVYFHLFYRDRPAGGRDTVRLNGDIVTAPAFGRLLDFMYE 85

                        90       100
                ....*....|....*....|....*
gi 33354238 108 SRIVINEENAESLLEAGDMLQFHDV 132
Cdd:cd18956  86 GRLDLRSLPVEDVLAAASYLHMYDI 110

BTB_POZ_BTBD14A_NAC2

cd18289

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

32-146

4.83e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349598 [Multi-domain] Cd Length: 131 Bit Score: 55.04 E-value: 4.83e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  32 VLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESrddtVNFQDNLHPEVLELLLDFAYSSRIV 111
Cdd:cd18289  16 VLGCLNEQRLMGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSGNSKSA----FELPATVPPACFQQILSFCYTGKLT 91

                        90       100       110
                ....*....|....*....|....*....|....*
gi 33354238 112 INEENAESLLEAGDMLQFHDVRDAAAEFLEKNLSP 146
Cdd:cd18289  92 MAASEQLVVMYTAGFLQIQHIVERGTDLMFKVSSP 126

BTB_POZ_ZBTB34

cd18220

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

23-141

5.03e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34); ZBTB34 acts as a transcriptional regulator. It downregulates specificity protein (Sp) transcription factors Sp1, Sp3, and Sp4 in pancreatic cancer cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349529 [Multi-domain] Cd Length: 120 Bit Score: 54.65 E-value: 5.03e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  23 FHKASHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNfqdnLHPEVLELLL 102
Cdd:cd18220   3 FDVPEYSNTVLSQLNELRLQGKLCDIIVHIQGQPFRAHKAVLAASSPYFRDHSALSTMSGLSISVI----KNPNVFEQLL 78

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 33354238 103 DFAYSSRIVINEENAESLLEAGDMLQFHDVRDAAAEFLE 141
Cdd:cd18220  79 SFCYTGRMSLQLKDVVSFLTAASFLQMQCVIDKCTQILE 117

BTB_POZ_ZBTB43

cd18227

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

32-143

5.26e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349536 [Multi-domain] Cd Length: 121 Bit Score: 54.56 E-value: 5.26e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  32 VLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYF--EAMFSHGLResrddtVNFQDNLHPEVLELLLDFAYSSR 109
Cdd:cd18227  12 ILQKLNQQRQQGQLCDISVVVQGHLFRAHKAVLAASSPYFcdQVLLKNSRR------IVLPDVMNPRVFENILLSCYTGR 85

                        90       100       110
                ....*....|....*....|....*....|....
gi 33354238 110 IVINEENAESLLEAGDMLQFHDVRDAAAEFLEKN 143
Cdd:cd18227  86 LVLPAPEIVSYLTAASFLQMWHVVDKCTELLEGN 119

BTB2_POZ_RhoBTB

cd18300

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

44-128

5.58e-09

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349609 [Multi-domain] Cd Length: 108 Bit Score: 53.78 E-value: 5.58e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  44 MFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQDnLHPEVLELLLDFAYSSRIVINEEN-AESLLE 122
Cdd:cd18300   8 LFSDVTFIVEDGTIPAHKALLVARCDVMAAMFGGNFRESSAKEVELPG-VSKETFLALLEYLYTDQAPILEDGdCVGLIV 86


                ....*.
gi 33354238 123 AGDMLQ 128
Cdd:cd18300  87 LANRLC 92

BTB_POZ_ZBTB29_HIC1

cd18333

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

27-143

8.43e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1); Hic-1, also called zinc finger and BTB domain-containing protein 29 (ZBTB29), is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. It may act as a tumor suppressor, and is involved in regulatory loops modulating P53-dependent and E2F1-dependent cell survival, growth control, and stress responses. It also regulates intestinal immunity and homeostasis. Hic-1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349642 [Multi-domain] Cd Length: 121 Bit Score: 53.75 E-value: 8.43e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  27 SHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHglresrDDTVNF-QDNLHPEVLELLLDFA 105
Cdd:cd18333   3 SHSRQLLLQLNTQRTKGFLCDVIIVVQNALFRAHKNILAASSVYLKSLVVH------DNLINLdHEMVSPGIFRLILDYI 76

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 33354238 106 YSSRIVINEENAE----SLLEAGDMLQFHDVRDAAAEFLEKN 143
Cdd:cd18333  77 YTGRLSEGDPGSEqnlgAVLAAASYLQIPDLVALCKKKLKRN 118

BTB_POZ_ZBTB41

cd18226

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-135

8.97e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41); ZBTB41, also called FRBZ1, may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349535 [Multi-domain] Cd Length: 114 Bit Score: 53.65 E-value: 8.97e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  28 HPDCVLAHLNTLR-KHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFShglRESRDDTVNFqDNLHPEVLELLLDFAY 106
Cdd:cd18226   4 YNKNLLKYLNDDRqKQSSFCDLVITVEGKEFSAHKVVVAVGSSYFHACLS---KNPNTDAVTL-DHVSYSVFQHLLEFLY 79

                        90       100
                ....*....|....*....|....*....
gi 33354238 107 SSRIVINEENAESLLEAGdmlQFHDVRDA 135
Cdd:cd18226  80 TSEFFVYENEIPLVLEAA---KFLDIIDA 105

BTB_POZ_ZBTB29-like

cd18216

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

27-132

9.22e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349525 [Multi-domain] Cd Length: 118 Bit Score: 53.69 E-value: 9.22e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  27 SHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHglresrDDTVNF-QDNLHPEVLELLLDFA 105
Cdd:cd18216   2 SHATQLLLQLNNQRTKGFLCDVIIVVENSLFRAHKNVLAASSGYFKSLVLH------DNLIHLdQDMVSPTVFQQILDFI 75

                        90       100       110
                ....*....|....*....|....*....|
gi 33354238 106 YSSRIV---INEENAESLLEAGDMLQFHDV 132
Cdd:cd18216  76 YTGKLLdslFEEPNLSEVLAAANYLQLPDL 105

Kelch_1

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

377-431

9.64e-09

Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 51.46 E-value: 9.64e-09

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 33354238   377 ARFGHGSAELENCLYVVGGHTSlagifpaspSVSLKQVEKYDPGDNKWTMVAPMR 431
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDG---------NQSLNSVEVYDPETNTWSKLPSMP 46

Kelch_1

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

329-374

2.03e-08

Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 50.30 E-value: 2.03e-08

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 33354238   329 PRKEFSASAIGCKVYVTGGRGSENGVSkDVWVYDTVHEEWSKAAPM 374
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLN-SVEVYDPETNTWSKLPSM 45

BTB_POZ_ZBTB3

cd18323

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-132

2.03e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3); ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB3 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349632 [Multi-domain] Cd Length: 128 Bit Score: 52.91 E-value: 2.03e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  28 HPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEaMFSHGLRESRDDTVNFQDNLHPEVLELLLDFAYS 107
Cdd:cd18323   6 HSRHLLQSLREQRHQGFLCDCTVLVGSTQFLAHRAVLASCSPFFH-MFYKEQLDKRDLVCINNEIVTAPAFSLLLEFMYE 84

                        90       100
                ....*....|....*....|....*
gi 33354238 108 SRIVINEENAESLLEAGDMLQFHDV 132
Cdd:cd18323  85 GRLSFNDTPVEDVLAAASYLHMNDI 109

Kelch

Kelch domain;

539-585

2.24e-08

Kelch domain;

Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 50.25 E-value: 2.24e-08

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 33354238    539 KLYVVGGYFGTQRCKTLDCYDPTSDTWNCITTVPYSLIPTAFVSTWK 585
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47

BTB_POZ_ZBTB5

cd18196

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-146

2.32e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 5 (ZBTB5); ZBTB5 is a POZ domain Kruppel-like zinc finger (POK) family transcription repressor of cell cycle arrest gene p21 and a potential proto-oncogene stimulating cell proliferation. ZBTB5 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349505 [Multi-domain] Cd Length: 126 Bit Score: 52.74 E-value: 2.32e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  28 HPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFShgLRESrDDTVNF----QDNLHPEVLELLLD 103
Cdd:cd18196   4 HFEQIFQQLNYQRLHGQLCDCVIVVGNRHFKAHRSVLAACSTHFRALFT--VAEG-DQTMNMiqldSEVVTAEAFAALID 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 33354238 104 FAYSSRIVINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLSP 146
Cdd:cd18196  81 MMYTSTLMLGESNVMDVLLAASHLHLNSVVKACKHYLTTRTLP 123

BTB_POZ_BTBD1_2

cd18281

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

58-148

2.36e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349590 [Multi-domain] Cd Length: 127 Bit Score: 52.82 E-value: 2.36e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  58 PCHRAVLAASSRYFEAMFSHGLReSRDDTVNFQDnLHPEVLELLLDFAYSSRIVINEENAESLLEAGDMLQFHDVRDAAA 137
Cdd:cd18281  39 PAHKFVLSIGSAVFDAMFNGGMA-TTSAEIELPD-VEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALESACV 116

                        90
                ....*....|.
gi 33354238 138 EFLEKNLSPSN 148
Cdd:cd18281 117 EFLKKNLSSDN 127

BTB_POZ_ZBTB16_PLZF

cd18205

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-140

3.20e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 16 (ZBTB16); ZBTB16 is also called promyelocytic leukemia zinc finger protein, zinc finger protein 145, or zinc finger protein PLZF. It is a DNA-binding transcription factor essential for undifferentiated cell maintenance. ZBTB16 also acts as a downstream transcriptional regulator of Osterix and can be useful as a late marker of osteoblastic differentiation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349514 [Multi-domain] Cd Length: 107 Bit Score: 51.96 E-value: 3.20e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  28 HPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFShglRESRDDTVNFqdnLHPEVLELLLDFAYS 107
Cdd:cd18205   1 HPTGLLHKANQMRLAGTLCDVVIMVDSQEFHAHRTVLACTSKMFEILFH---RNSQHYTLDF---LSPKTFQQILEYAYT 74

                        90       100       110
                ....*....|....*....|....*....|...
gi 33354238 108 SRIVINEENAESLLEAGDMLQFHDVRDAAAEFL 140
Cdd:cd18205  75 ATLQAKVEDLDDLLYAAEILEIEYLEEQCLKIL 107

BTB_POZ_ZBTB49

cd18233

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-141

3.41e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49); ZBTB49, also called zinc finger protein 509 (ZNF509), is a transcription factor that inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. There are four ZNF509 isoforms generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). ZBTB49 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349542 [Multi-domain] Cd Length: 112 Bit Score: 51.82 E-value: 3.41e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  28 HPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDdtVNFQDNLHPEVLELLLDFAYS 107
Cdd:cd18233   1 HSCHLLQQLHEQRIQGLLCDCMLVVKGVCFKAHKNVLAAFSQYFRSLFQNSSSQKND--VFHLDIKNVGGIGQILDFMYT 78

                        90       100       110
                ....*....|....*....|....*....|....
gi 33354238 108 SRIVINEENAESLLEAGDMLQFHDVRDAAAEFLE 141
Cdd:cd18233  79 SHLDLNQDNVQVMLDIAQCLQVQNVLNMCYTFLK 112

BACK_KLHL7

cd18447

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a ...

147-240

3.61e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a BTB-Kelch protein that constitutes a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 cause autosomal-dominant retinitis pigmentosa.

Pssm-ID: 350522 [Multi-domain] Cd Length: 98 Bit Score: 51.59 E-value: 3.61e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238 147 SNCLGMMVLSDAHQCRRLYEFSCRMSLVHFETVRQSEDFNSLSRDTLLDLISRDELETEDERVVFEAILQWVKHDLEQRK 226
Cdd:cd18447   5 SNCLGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDEPNRQ 84

                        90
                ....*....|....
gi 33354238 227 AHLPLLLRNVRLAL 240
Cdd:cd18447  85 PYMVDILAKVRFPL 98

BTB_POZ_ZBTB35_ZNF131

cd18221

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-131

3.89e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349530 [Multi-domain] Cd Length: 113 Bit Score: 51.93 E-value: 3.89e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  28 HPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTvnfqDNLHPEVLELLLDFAYS 107
Cdd:cd18221   1 HYKVMLDRLNEQRELDQFTDITLIVDGHQFKAHKAVLAACSQFFYKFFQDFTQEPLVEI----EGVSNMAFRHLIEFTYT 76

                        90       100
                ....*....|....*....|....*
gi 33354238 108 SRIVIN-EENAESLLEAGDMLQFHD 131
Cdd:cd18221  77 AKLMVQgEEEANDVWKAAEYLQMQE 101

Kelch

Kelch domain;

341-388

3.99e-08

Kelch domain;

Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 49.48 E-value: 3.99e-08

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 33354238    341 KVYVTGGRGSENgVSKDVWVYDTVHEEWSKAAPMLIARFGHGSAELEN 388
Cdd:smart00612   1 KIYVVGGFDGGQ-RLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47

BTB1_POZ_RhoBTB

cd18299

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

36-135

4.67e-08

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349608 [Multi-domain] Cd Length: 103 Bit Score: 51.06 E-value: 4.67e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  36 LNTLRKHCMFTDVTLWAGDR-AFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNfqdnlhPEVLELLLDFAYSSRIVINE 114
Cdd:cd18299   3 LRNLLHSPSCADVVFILQGGvRIFAHRIVLAAASSVFADLFLMMTVVTLDSDIT------PEAFRRVLEFLYTGVLDENE 76

                        90       100
                ....*....|....*....|.
gi 33354238 115 ENAESLLEAGDMLQFHDVRDA 135
Cdd:cd18299  77 DDLKELKDAAELLELFDLVMM 97

NanM

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

517-565

6.63e-08

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

Pssm-ID: 442289 [Multi-domain] Cd Length: 277 Bit Score: 54.39 E-value: 6.63e-08

                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 33354238 517 QWTRIGDMTAKRMSCHAVASGNKLYVVGGYFGTQRCKTLDCYDPTSDTW 565
Cdd:COG3055   2 TWSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTW 50

BACK_KLHL11

cd18451

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a ...

144-229

7.56e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.

Pssm-ID: 350526 [Multi-domain] Cd Length: 88 Bit Score: 50.34 E-value: 7.56e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238 144 LSPSNCLGMMVLSDAHQCRRLYEFSCRMSLVHFETVRQSEDFNSLSRDTLLDLISRDELETEDERVVFEAILQWVKHDLE 223
Cdd:cd18451   1 LNLSNCVAIHSLAHMYSLDQLALKAADMIRRNFHKVIQDEEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVLKWVQRNAE 80


                ....*.
gi 33354238 224 QRKAHL 229
Cdd:cd18451  81 ERERYF 86

BTB_POZ_KLHL31_KBTBD1

cd18260

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-150

9.88e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349569 [Multi-domain] Cd Length: 120 Bit Score: 50.58 E-value: 9.88e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  28 HPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFShglRESRDDTVNFQDnLHPEVLELLLDFAYS 107
Cdd:cd18260   1 YGANLLEGLNRMRQERFLCDLTIATKTKSFDVHKVVMASCSEYFRNILK---KDPSLQRVELND-ISPLGLATVITYAYT 76

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 33354238 108 SRIVINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLSPSNCL 150
Cdd:cd18260  77 GKLTLSLYTIGSTISAASYLQIHALVKMCCDFLMQEMNVENCM 119

BTB_POZ_BTBD18

cd18293

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

45-132

1.32e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349602 [Multi-domain] Cd Length: 120 Bit Score: 50.56 E-value: 1.32e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  45 FTDVTLWAGDRAFPCHRAVLAASSRYFEAMFShglRESRDDTvnfqdnlHPEVLEL----------LLDFAYSSRIVINE 114
Cdd:cd18293  15 FCDVLLQAEGESVPAHCCVLSACSPYLTERLS---SEPPPAG-------QKVVLELqglkahtllkLVDFLYTSELEVSS 84

                        90
                ....*....|....*...
gi 33354238 115 ENAESLLEAGDMLQFHDV 132
Cdd:cd18293  85 EEAQDVLAAARRLQISEL 102

BTB_POZ_ZBTB14

cd18204

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-131

1.32e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14); ZBTB14 is also called zinc finger protein 161 (Zfp-161), zinc finger protein 478, zinc finger protein 5 (ZF5), or Zfp-5. It is a novel transcriptional activator of the dopamine transporter, binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. It also binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. ZBTB14 acts as a transcriptional repressor of MYC and thymidine kinase promoters. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349513 [Multi-domain] Cd Length: 114 Bit Score: 50.42 E-value: 1.32e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  28 HPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHglRESRDDTVNFQDNLHPEVLELLLDFAYS 107
Cdd:cd18204   1 HKTVFLKTLNEQRLEGEFCDIAIVVEDVKFRAHRCVLAACSTYFKKLFKK--LEVDSSSVIEIDFLRSDIFEEVLNYMYT 78

                        90       100
                ....*....|....*....|....*.
gi 33354238 108 SRIVINEENAESLLEAGDML--QFHD 131
Cdd:cd18204  79 AKISVKKEDVNLMMSSGQILgiRFLD 104

BACK_BTBD9

cd14822

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); ...

160-242

1.67e-07

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation.

Pssm-ID: 350518 [Multi-domain] Cd Length: 101 Bit Score: 49.53 E-value: 1.67e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238 160 QCRRLYEFSCRMSLVHFETVRQSEDFNSLSRDTLLDLISRDELETeDERVVFEAILQWVKHDLEQRKAHLPlLLRNVRLA 239
Cdd:cd14822  17 SLDDLCQTCCQFMDRNAQEVLSSEGFLTLSKSALKELLSRDSFCA-PEVDIFNAVRRWCEHNPDSKEDAKE-ILEAVRLP 94


                ...
gi 33354238 240 LLP 242
Cdd:cd14822  95 LMS 97

PLN02153

epithiospecifier protein

327-545

1.86e-07

epithiospecifier protein

Pssm-ID: 177814 [Multi-domain] Cd Length: 341 Bit Score: 53.45 E-value: 1.86e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  327 PSPRKEFSASAIGCKVYVTGGRGSEN-GVSKDVWVYDTVHEEWSKAAPM----LIARFGHGSAELENCLYVVGGHTSlag 401
Cdd:PLN02153  20 PGPRCSHGIAVVGDKLYSFGGELKPNeHIDKDLYVFDFNTHTWSIAPANgdvpRISCLGVRMVAVGTKLYIFGGRDE--- 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  402 ifpaspSVSLKQVEKYDPGDNKWTMVAPM-RDGVSNA----AVVSAKLKLFVFGGTSIHRDMVS-----KVQCFDPSENR 471
Cdd:PLN02153  97 ------KREFSDFYSYDTVKNEWTFLTKLdEEGGPEArtfhSMASDENHVYVFGGVSKGGLMKTperfrTIEAYNIADGK 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  472 WtikAECPQPW-----RYTAA-AVLGSQIFIM---------GGDTEYTAASAYRFDCETNQWTRI----GDMTAKRMSCH 532
Cdd:PLN02153 171 W---VQLPDPGenfekRGGAGfAVVQGKIWVVygfatsilpGGKSDYESNAVQFFDPASGKWTEVettgAKPSARSVFAH 247

                        250
                 ....*....|...
gi 33354238  533 AVAsGNKLYVVGG 545
Cdd:PLN02153 248 AVV-GKYIIIFGG 259

BTB_POZ_KBTBD11

cd18275

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

47-150

3.02e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11 is also called chronic myelogenous leukemia-associated protein (CMLAP) or Kelch domain-containing protein 7B, or KLHDC7C. It is a BTB-Kelch family protein whose function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349584 [Multi-domain] Cd Length: 104 Bit Score: 49.02 E-value: 3.02e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  47 DVTLWAGDRAFPCHRAVLAASSRYFEAmfshglRESRDdTVNFQdNLHPEVLELLLDFAYSSRIVINEENAESLLEAGDM 126
Cdd:cd18275   6 DLVIEVSGQRIRAHKSVLAAKSDYFRA------RLSRD-ILKVK-GLSYATLRLLVDYVYSGRMAVSKDNVVEVVAGARF 77

                        90       100
                ....*....|....*....|....
gi 33354238 127 LQFHDVRDAAAEFLEKNLSPSNCL 150
Cdd:cd18275  78 LQMPCAAQCAVDAVRAQLCLGNCY 101

BTB_POZ_ZBTB23_GZF1

cd18211

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

27-132

3.07e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1); GZF1 is also called GDNF-inducible zinc finger protein 1, zinc finger and BTB domain-containing protein 23 (ZBTB23), or zinc finger protein 336 (ZNF336). It is a sequence-specific transcriptional repressor that binds the GZF1 responsive element (GRE), with the consensus sequence of 5'-TGCGCN[TG][CA]TATA-3'. It may play a role in renal branching morphogenesis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349520 [Multi-domain] Cd Length: 128 Bit Score: 49.47 E-value: 3.07e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  27 SHPDCVLAHLNTLRKHCMFTDVTL---WAGDRA-FPCHRAVLAASSRYFEAMF-SHGLRESRDDTVNFQDnLHPEVLELL 101
Cdd:cd18211   7 SAPSNLLNEMHKLRLLGHLCDVTVqveHQGSKEeFSAHKAVLAASSKYFKEVFlNEKISDGKNTNVMLNE-IYTADFASF 85

                        90       100       110
                ....*....|....*....|....*....|.
gi 33354238 102 LDFAYSSRIVINEENAESLLEAGDMLQFHDV 132
Cdd:cd18211  86 LEFVYTAKVEVEEDRVQRMLEIAEKLKCLDL 116

PLN02193

nitrile-specifier protein

331-569

3.52e-07

nitrile-specifier protein

Pssm-ID: 177844 [Multi-domain] Cd Length: 470 Bit Score: 53.04 E-value: 3.52e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  331 KEFSASAIGCKVYVTGGRGSENGVSKDVWVYDTVHEEWSKAAPMLIARFG-----HGSAelenclyVVGGHTSLAGIFPA 405
Cdd:PLN02193  64 EEFEIDADDYIVYVEGYREKVNDMTSEMITFLSFKTYKGKTSHPIEKRPGvkfvlQGGK-------IVGFHGRSTDVLHS 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  406 SPS-VSLKQVEKYDpgdNKWTMVAPMRDGVS---NAAVVSAKLKLFVFGGTSIHRDMVSK-VQCFDPSENRWTIKAECPQ 480
Cdd:PLN02193 137 LGAyISLPSTPKLL---GKWIKVEQKGEGPGlrcSHGIAQVGNKIYSFGGEFTPNQPIDKhLYVFDLETRTWSISPATGD 213

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  481 PWRYTAAAV----LGSQIFIMGG-DTEYTAASAYRFDCETNQW---TRIGDMTAKRmSCHAVASG-NKLYVVGGYFGTQR 551
Cdd:PLN02193 214 VPHLSCLGVrmvsIGSTLYVFGGrDASRQYNGFYSFDTTTNEWkllTPVEEGPTPR-SFHSMAADeENVYVFGGVSATAR 292

                        250
                 ....*....|....*....
gi 33354238  552 CKTLDCYDPTSDTW-NCIT 569
Cdd:PLN02193 293 LKTLDSYNIVDKKWfHCST 311

BTB_POZ_ZBTB45

cd18229

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

32-143

3.95e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45); ZBTB45, also called zinc finger protein 499 (ZNF499), may act as a transcriptional regulator that is essential for proper glial differentiation of neural and oligodendrocyte progenitor cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349538 [Multi-domain] Cd Length: 112 Bit Score: 48.70 E-value: 3.95e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  32 VLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVnfqdnLHPEVLELLLDFAYSSRIV 111
Cdd:cd18229   5 LLETLNAQRLGGHFCDVTVRIHDASLRAHRCVLAAGSPFFHDKLLLGHSEIEVPPV-----VPAQTVRQLVEFMYSGSLV 79

                        90       100       110
                ....*....|....*....|....*....|..
gi 33354238 112 INEENAESLLEAGDMLQFHDVRDAAAEFLEKN 143
Cdd:cd18229  80 VAQSEALQILTAASILQIKTVIDECTQIISQS 111

BTB_POZ_ZBTB18_RP58

cd18324

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-132

5.62e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349633 [Multi-domain] Cd Length: 147 Bit Score: 49.27 E-value: 5.62e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  28 HPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLrESRDDTVNFQDNLHPEVLELLLDFAYS 107
Cdd:cd18324   6 HSRHLLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMYFHLFYKDQL-DKRDIVHLNSDIVTAPAFALLLEFMYE 84

                        90       100
                ....*....|....*....|....*
gi 33354238 108 SRIVINEENAESLLEAGDMLQFHDV 132
Cdd:cd18324  85 GKLQFKDLPIEDVLAAASYLHMYDI 109

BTB_POZ_ZBTB11

cd18202

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-113

5.80e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349511 [Multi-domain] Cd Length: 118 Bit Score: 48.69 E-value: 5.80e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  28 HPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMF-SHGLRESRDDTVNFQDNLHPEVLElLLDFAY 106
Cdd:cd18202   2 HGQTVLDQLNQQRLNNQFCDVTLLIEGEEYKAHKSVLAANSEYFRELFiEKGAVSSHEAVVDLSGFCKSSFLP-LLEFAY 80


                ....*..
gi 33354238 107 SSRIVIN 113
Cdd:cd18202  81 TSELTFD 87

Kelch_1

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

481-525

5.91e-07

Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 46.45 E-value: 5.91e-07

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 33354238   481 PWRYTAAAVLGSQIFIMGGDTEYTA-ASAYRFDCETNQWTRIGDMT 525
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSlNSVEVYDPETNTWSKLPSMP 46

BTB_POZ_ZBTB18_2-like

cd18325

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-146

6.59e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18.2 and similar proteins; This subfamily is composed of Xenopus laevis zinc finger and BTB domain-containing protein 18.2, encoded by the znf238.2.L gene, and similar proteins. Many proteins in this group are annotated as zinc finger and BTB domain-containing protein 42 (ZBTB42). However, characterized mammalian ZBTB42 does not belong to this subfamily. ZBTB18.2, like ZBTB18, functions as a transcriptional repressor that plays a role in various developmental processes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349634 [Multi-domain] Cd Length: 128 Bit Score: 48.49 E-value: 6.59e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  28 HPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLrESRDDTVNFQDNLHPEVLELLLDFAYS 107
Cdd:cd18325   6 HSRQLLQCLSQQRHQGFLCDCTVLVGEAQFRAHRAVLASCSMYFHLFYRDQL-DKRDIVHLNSDIVTAPAFSLLLEFMYE 84

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 33354238 108 SRIVINEENAESLLEAGDMLQFHD-VRDAAAEFLEKNLSP 146
Cdd:cd18325  85 GKLEFSSLPVEDVLAAASYLHMYDiVKVCKGKLKDKELCS 124

BTB_POZ_ZBTB25_ZNF46_KUP

cd18213

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

26-109

6.66e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25); ZBTB25, also called zinc finger protein 46 (ZNF46) or zinc finger protein KUP, is a transcription repressor that facilitates viral RNA transcription and replication. It interacts with viral RNA-dependent RNA polymerase (RdRp) proteins and modulates their transcription activity. It also functions as a viral RNA-binding protein, binding preferentially to the U-rich sequence within 5' UTR of vRNA. ZBTB25 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349522 [Multi-domain] Cd Length: 128 Bit Score: 48.74 E-value: 6.66e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  26 ASHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLREsrddTVNFQ-DNLHPEVLELLLDF 104
Cdd:cd18213   2 SSHSLVLLQQLNMQREFGFLCDCTVAIGDVYFKAHRAVLAAFSNYFKMIFIHQSSE----CIKIQpTDIQPDIFSYLLHI 77


                ....*
gi 33354238 105 AYSSR 109
Cdd:cd18213  78 MYTGK 82

BTB_POZ_ABTB2-like

cd18297

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

44-128

8.39e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349606 [Multi-domain] Cd Length: 117 Bit Score: 48.04 E-value: 8.39e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  44 MFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFqDNLHPEVLELLLDFAYS---SRIVINEENAESL 120
Cdd:cd18297  11 EMSDVTFLVEGRPFYAHKIVLVTASDRFKSMLSSGSTEAQTPVIEI-PDIRYDIFQLMMQYLYTggvESLDVAQDDALEL 89


                ....*...
gi 33354238 121 LEAGDMLQ 128
Cdd:cd18297  90 LRAASFFQ 97

PRK14131

N-acetylneuraminate epimerase;

325-501

1.50e-06

N-acetylneuraminate epimerase;

Pssm-ID: 237617 [Multi-domain] Cd Length: 376 Bit Score: 50.78 E-value: 1.50e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  325 DLPSPRKEFSASAIGCKVYVtgGRGSengVSKDVWVYDT--VHEEWSKaapmlIARFGHG------SAELENCLYVVGGh 396
Cdd:PRK14131  24 DLPVPFKNGTGAIDNNTVYV--GLGS---AGTSWYKLDLnaPSKGWTK-----IAAFPGGpreqavAAFIDGKLYVFGG- 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  397 tslAGIFPASPSVSL-KQVEKYDPGDNKWTMV---APMrdGVSNAAVVSA-KLKLFVFGGTSIH------RDMVS----- 460
Cdd:PRK14131  93 ---IGKTNSEGSPQVfDDVYKYDPKTNSWQKLdtrSPV--GLAGHVAVSLhNGKAYITGGVNKNifdgyfEDLAAagkdk 167

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 33354238  461 ----------------------KVQCFDPSENRWtiKAECPQPWRYTAaavlGSQIFIMGGDT 501
Cdd:PRK14131 168 tpkdkindayfdkkpedyffnkEVLSYDPSTNQW--KNAGESPFLGTA----GSAVVIKGNKL 224

BTB_POZ_ZBTB22_BING1

cd18210

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

32-140

1.65e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 22 (ZBTB22); ZBTB22, also called protein BING1 or zinc finger protein 297, may be involved in transcriptional regulation. Its gene, together with BING 3-5, TAPASIN, DAXX, RGL2, and HKE2, form a dense cluster at the centromeric end of the major histocompatibility complex class I region. ZBTB22 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349519 [Multi-domain] Cd Length: 112 Bit Score: 47.14 E-value: 1.65e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  32 VLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYF-EAMFSHGLresrdDTVNFQDNLHPEVLELLLDFAYSSRI 110
Cdd:cd18210   8 LLESLNQQRMEGKLCDISIHVQGRVFRAHRAVLAASSPYFhDQVLLKNM-----SSISLPGVMDPGAFESVLASAYTGKL 82

                        90       100       110
                ....*....|....*....|....*....|
gi 33354238 111 VINEENAESLLEAGDMLQFHDVRDAAAEFL 140
Cdd:cd18210  83 TMLADEIVNYLTVGSVLQMWHIVDKCTELL 112

BTB_POZ_CP190-like

cd18311

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...

33-128

2.12e-06

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster centrosomal protein 190kD (CP190) and similar proteins; CP190 is a large, multi-domain protein, first identified as a centrosome protein with oscillatory localization over the course of the cell cycle. It has an essential function in the nucleus as a chromatin insulator. It is known to associate with the nuclear matrix, components of the RNAi machinery, active promoters and borders of the repressive chromatin domains. CP190 contains an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349620 [Multi-domain] Cd Length: 110 Bit Score: 46.81 E-value: 2.12e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  33 LAHLNTLRKHCMFTDVTL-WAGDRAFPCHRAVLAASSRYFEAMfsHGLRESRDDTVNFQDNLHPEVLELLLDFAYSSRIV 111
Cdd:cd18311   2 LQRLQNLFNKTEYCDLTLqFRDNEQLKVHRLVLSACTDYFNVL--EQTCEIVDDTLIMPNELQADAVVPVINFMYTGQLE 79

                        90
                ....*....|....*..
gi 33354238 112 INEENAESLLEAGDMLQ 128
Cdd:cd18311  80 FEEKSYGKLLRTAKELN 96

Kelch_4

pfam13418

Galactose oxidase, central domain;

329-374

2.43e-06

Galactose oxidase, central domain;

Pssm-ID: 433191 [Multi-domain] Cd Length: 49 Bit Score: 44.53 E-value: 2.43e-06

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 33354238   329 PRKEFSASAIGC-KVYVTGGRGSENGVSKDVWVYDTVHEEWSKAAPM 374
Cdd:pfam13418   1 PRAYHTSTSIPDdTIYLFGGEGEDGTLLSDLWVFDLSTNEWTRLGSL 47

BTB_POZ_ZBTB2

cd18193

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

26-110

9.02e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 2 (ZBTB2); ZBTB2 is a POZ domain Kruppel-like zinc finger (POK) family transcription factor acting as a potent repressor of the ARF-HDM2-p53-p21 pathway, which is important in cell cycle regulation. It represses transcription of the ARF, p53, and p21 genes, but activates the HDM2 gene. ZBTB2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349502 [Multi-domain] Cd Length: 115 Bit Score: 44.98 E-value: 9.02e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  26 ASHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHglreSRDDTVNFQ-DNLHPEVLELLLDF 104
Cdd:cd18193   2 ANHGLILLQQLNAQREFGFLCDCTVAIGDVYFKAHKSVLASFSNYFKMLFVH----QTSECVRLKpTDIQPDIFSYLLHL 77


                ....*.
gi 33354238 105 AYSSRI 110
Cdd:cd18193  78 MYTGKM 83

BACK_KLHL36

cd18475

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act ...

144-242

9.04e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Pssm-ID: 350550 Cd Length: 100 Bit Score: 44.45 E-value: 9.04e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238 144 LSPSNCLGMMVLSDAHQCRRLYEFSCRMSLVHFETVRQSEDF-NSLSRDTLLDLISRDELETEDERVVFEAILQWVKHDL 222
Cdd:cd18475   1 VSEENYLYLQELASIYSLERLDSFIDSFILQNFGTLSFTPDFlQNVSMQKLCQYLSSNQVQHECEHDLLQAALQWLTQSP 80

                        90       100
                ....*....|....*....|
gi 33354238 223 EqRKAHLPLLLRNVRLALLP 242
Cdd:cd18475  81 E-RENEAYQVLSNIHFPLIP 99

PLN02193

nitrile-specifier protein

378-570

9.83e-06

nitrile-specifier protein

Pssm-ID: 177844 [Multi-domain] Cd Length: 470 Bit Score: 48.41 E-value: 9.83e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  378 RFGHGSAELENCLYVVGGHTSlagifPASPSVslKQVEKYDPGDNKWTmVAPMRDGVSNAA-----VVSAKLKLFVFGGT 452
Cdd:PLN02193 166 RCSHGIAQVGNKIYSFGGEFT-----PNQPID--KHLYVFDLETRTWS-ISPATGDVPHLSclgvrMVSIGSTLYVFGGR 237

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  453 SIHRDMvSKVQCFDPSENRW---TIKAECPQPWRYTAAAVLGSQIFIMGGDT---------EYTAASAYRFDCETNQwtr 520
Cdd:PLN02193 238 DASRQY-NGFYSFDTTTNEWkllTPVEEGPTPRSFHSMAADEENVYVFGGVSatarlktldSYNIVDKKWFHCSTPG--- 313

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 33354238  521 iGDMTAKRMSCHAVASGnKLYVVGGYFGtqrCKTLD--CYDPTSDTWNCITT 570
Cdd:PLN02193 314 -DSFSIRGGAGLEVVQG-KVWVVYGFNG---CEVDDvhYYDPVQDKWTQVET 360

BTB_POZ_ZBTB9

cd18200

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-142

1.02e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 9 (ZBTB9); ZBTB9 may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349509 [Multi-domain] Cd Length: 111 Bit Score: 44.84 E-value: 1.02e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  28 HPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEamfsHGLRESRDDTVNFQDNLHPEVLELLLDFAYS 107
Cdd:cd18200   1 YSSALLETLNKHRLEGKFCDLSVHVQGRVFRAHKAVLAASSPYFH----DKLLLNDTNCLVLPSVIEAAAFENLLQLIYS 76

                        90       100       110
                ....*....|....*....|....*....|....*
gi 33354238 108 SRIVINEENAESLLEAGDMLQFHDVRDAAAEFLEK 142
Cdd:cd18200  77 GRLTLCMDALPSHLLVASGLQMWQVVDRCSELLKE 111

Kelch_6

pfam13964

Kelch motif;

481-528

1.16e-05

Kelch motif;

Pssm-ID: 404790 [Multi-domain] Cd Length: 50 Bit Score: 42.71 E-value: 1.16e-05

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 33354238   481 PWRYTAAAVLGSQIFIMGGDTEYTAASA--YRFDCETNQWTRIGDMTAKR 528
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYTNASPALNklEVYNPLTKSWEELPPLPTPR 50

BTB_POZ_ZBTB32_FAZF_TZFP

cd18218

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-135

1.18e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 32 (ZBTB32); ZBTB32 is also called FANCC-interacting protein, fanconi anemia zinc finger protein (FAZF), testis zinc finger protein (TZFP), or zinc finger protein 538 (ZNF538). It is a DNA-binding transcription factor that binds to the 5'-TGTACAGTGT-3' core sequence. It acts as a transcription suppressor that controls T cell-mediated autoimmunity. ZBTB32 is essential for down-regulation of GATA3 via ZPO2; this promotes aggressive breast cancer development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349527 [Multi-domain] Cd Length: 110 Bit Score: 44.54 E-value: 1.18e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  28 HPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRyfeaMFSHGLRESRDDTVNFQDNLHPEVLELLLDFAYS 107
Cdd:cd18218   1 HSDRLLHLAARLRPAGALCDTLITVGSQEFPAHSLVLAGASQ----QLGRQLTNPNPGQWCLGEGISPSTFKQLLDFVYG 76

                        90       100
                ....*....|....*....|....*...
gi 33354238 108 SRIVINEENAESLLEAGDMLQFHDVRDA 135
Cdd:cd18218  77 ESVEVQPGELRPLLEAARALEVESLEEA 104

BTB_POZ_ZBTB26_Bioref

cd18214

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

23-146

1.40e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 26 (ZBTB26); ZBTB26, also called zinc finger protein 481 (ZNF481) or zinc finger protein Bioref, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349523 [Multi-domain] Cd Length: 122 Bit Score: 44.82 E-value: 1.40e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  23 FHKASHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFShgLRESRDDTVNFQDNlhPEVLELLL 102
Cdd:cd18214   3 FRFENYGDSMLQKMNKLREQNKFCDVTVHIDDLEVPGHKVVFAAGSPFLRDQFL--LNDSREVQISILQN--SEVGRQLL 78

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 33354238 103 DFAYSSRIVINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLSP 146
Cdd:cd18214  79 LSCYTGVLEFPEMELVNYLTAASFLQMSHIVERCTQALWKFIKP 122

Kelch

Kelch domain;

493-539

1.77e-05

Kelch domain;

Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 42.16 E-value: 1.77e-05

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 33354238    493 QIFIMGG-DTEYTAASAYRFDCETNQWTRIGDMTAKRMScHAVASGNK 539
Cdd:smart00612   1 KIYVVGGfDGGQRLKSVEVYDPETNKWTPLPSMPTPRSG-HGVAVING 47

muta_rot_YjhT

TIGR03547

mutatrotase, YjhT family; Members of this protein family contain multiple copies of the ...

325-547

1.85e-05

Pssm-ID: 274641 [Multi-domain] Cd Length: 346 Bit Score: 46.93 E-value: 1.85e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238   325 DLPSPRKEFSASAIGCKVYVtgGRGSengVSKDVWVYDT--VHEEWSKAAPML-IARFGHGSAELENCLYVVGGhtslAG 401
Cdd:TIGR03547   3 DLPVGFKNGTGAIIGDKVYV--GLGS---AGTSWYKLDLkkPSKGWQKIADFPgGPRNQAVAAAIDGKLYVFGG----IG 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238   402 IFPASPSVS-LKQVEKYDPGDNKWTMVaPMRDGVSNAAVVSAKL---KLFVFGGT-----------------------SI 454
Cdd:TIGR03547  74 KANSEGSPQvFDDVYRYDPKKNSWQKL-DTRSPVGLLGASGFSLhngQAYFTGGVnknifdgyfadlsaadkdsepkdKL 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238   455 HRDMVSK----------VQCFDPSENRWTIKAECPQPWRYTAAAVL-GSQIFIMGGDTE---YTAAS-AYRFDCETNQWT 519
Cdd:TIGR03547 153 IAAYFSQppedyfwnknVLSYDPSTNQWRNLGENPFLGTAGSAIVHkGNKLLLINGEIKpglRTAEVkQYLFTGGKLEWN 232

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 33354238   520 RIGDMTAKRMSCH-AVA------SGNKLYVVGG-YF 547
Cdd:TIGR03547 233 KLPPLPPPKSSSQeGLAgafagiSNGVLLVAGGaNF 268

BTB_POZ_BTBD1

cd18346

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

53-148

1.92e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 1 (BTBD1); BTBD1, also called Hepatitis C virus NS5A-transactivated protein 8 or HCV NS5A-transactivated protein 8, is a BTB-domain-containing Kelch-like protein that is expressed in skeletal muscle and interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. BTBD1 may serve as substrate-specific adaptor of an E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349655 [Multi-domain] Cd Length: 133 Bit Score: 44.66 E-value: 1.92e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  53 GDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDtVNFQDnLHPEVLELLLDFAYSSRIVINEENAESLLEAGDMLQFHDV 132
Cdd:cd18346  40 GAQRIPAHRFVLAAGSAVFDAMFNGGMATTSAE-IELPD-VEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPAL 117

                        90
                ....*....|....*.
gi 33354238 133 RDAAAEFLEKNLSPSN 148
Cdd:cd18346 118 EAHCVEFLTKHLRADN 133

BTB1_POZ_BTBD8

cd18285

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

44-120

1.92e-05

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349594 [Multi-domain] Cd Length: 104 Bit Score: 43.88 E-value: 1.92e-05

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 33354238  44 MFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGL-RESRDDTVNFqDNLHPEVLELLLDFAYSSRIVINEENAESL 120
Cdd:cd18285  14 LHTDVTFYVGSTLFKAHKAILLARVPEFFSHIIGKLsSLEDQEPINI-ENLEASEFKTFLRQVYTSDKNIKMLEEEIL 90

BACK_BTBD17

cd18493

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); ...

176-218

1.93e-05

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also termed galectin-3-binding protein-like, is a BTB-domain-containing Kelch-like protein. Its function remains unclear. It may be involved in hepatocellular carcinoma development and progression.

Pssm-ID: 350568 Cd Length: 74 Bit Score: 42.95 E-value: 1.93e-05

                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 33354238 176 FETVRQSEDFNSLSRDTLLDLISRDELETEDERVVFEAILQWV 218
Cdd:cd18493  32 FEKVLKSPDWLNLDLDLLVSLLQSSDLVVEDEYTLFQAVEKWL 74

Kelch_3

pfam13415

Galactose oxidase, central domain;

339-384

2.93e-05

Galactose oxidase, central domain;

Pssm-ID: 433188 [Multi-domain] Cd Length: 49 Bit Score: 41.51 E-value: 2.93e-05

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 33354238   339 GCKVYVTGGRGSENG-VSKDVWVYDTVHEEWSKAAPMLIARFGHGSA 384
Cdd:pfam13415   1 GDKLYIFGGLGFDGQtRLNDLYVYDLDTNTWTQIGDLPPPRSGHSAT 47

BTB_POZ_ZBTB6

cd18197

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

23-128

3.00e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 6 (ZBTB6); ZBTB6, also called zinc finger protein 482 (ZNF482) or zinc finger protein with interaction domain, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349506 [Multi-domain] Cd Length: 116 Bit Score: 43.71 E-value: 3.00e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  23 FHKASHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFShgLRESRDDTVNFQDNlhPEVLELLL 102
Cdd:cd18197   3 FKFEQQGDAVLQKMNLLRQQNLFCDVSIYINDTEFHGHKVILAACSTFMRDQFL--LNQSKQVRITILQS--AEVGRKLL 78

                        90       100
                ....*....|....*....|....*.
gi 33354238 103 DFAYSSRIVINEENAESLLEAGDMLQ 128
Cdd:cd18197  79 LSCYTGALEVKKKELLKYLTAASYLQ 104

PRK14131

N-acetylneuraminate epimerase;

468-546

3.00e-05

N-acetylneuraminate epimerase;

Pssm-ID: 237617 [Multi-domain] Cd Length: 376 Bit Score: 46.55 E-value: 3.00e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  468 SENRWTIKAECPQPWRYTA-AAVLGSQIFIMGG------DTEYTAAS-AYRFDCETNQWTRIGDMTAKRMSCHAVAS--G 537
Cdd:PRK14131  60 PSKGWTKIAAFPGGPREQAvAAFIDGKLYVFGGigktnsEGSPQVFDdVYKYDPKTNSWQKLDTRSPVGLAGHVAVSlhN 139


                 ....*....
gi 33354238  538 NKLYVVGGY 546
Cdd:PRK14131 140 GKAYITGGV 148

Kelch_6

pfam13964

Kelch motif;

329-378

3.76e-05

Kelch motif;

Pssm-ID: 404790 [Multi-domain] Cd Length: 50 Bit Score: 41.17 E-value: 3.76e-05

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 33354238   329 PRKEFSASAIGCKVYVTGGRGSENGVSKDVWVYDTVHEEWSKAAPMLIAR 378
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYTNASPALNKLEVYNPLTKSWEELPPLPTPR 50

BTB_POZ_BTBD2

cd18347

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

53-148

4.14e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 2 (BTBD2); BTBD2 is a BTB-domain-containing Kelch-like protein that interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349656 [Multi-domain] Cd Length: 127 Bit Score: 43.52 E-value: 4.14e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  53 GDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDtVNFQDnLHPEVLELLLDFAYSSRIVINEENAESLLEAGDMLQFHDV 132
Cdd:cd18347  34 GSQRIPAHRFVLAVGSAVFDAMFNGGMATTSTE-IELPD-VEPAAFLALLKFLYSDEVQIGPETVMTTLYTAKKYAVPAL 111

                        90
                ....*....|....*.
gi 33354238 133 RDAAAEFLEKNLSPSN 148
Cdd:cd18347 112 EAHCVEFLKKNLRADN 127

BTB_POZ_KBTBD13

cd18320

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

45-90

7.48e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 13 (KBTBD13); KBTBD13 is a muscle specific protein. Its autosomal dominant mutations may cause Nemaline Myopathy (NEM). KBTBD13 may act as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that functions as a muscle specific ubiquitin ligase, and thereby implicating the ubiquitin proteasome pathway in the pathogenesis of KBTBD13-associated NEM. KBTBD13 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349629 [Multi-domain] Cd Length: 83 Bit Score: 41.64 E-value: 7.48e-05

                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 33354238  45 FTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQ 90
Cdd:cd18320   1 MQKVKVWVEEQLFTVDKALLVENSEYFRALFRSGMRECTQDEIRLQ 46

BACK_BTBD6

cd18525

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 6 (BTBD6); ...

177-240

7.56e-05

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 6 (BTBD6); BTBD6, also called lens BTB domain protein, is a BTB-domain-containing Kelch-like protein that is required for proper embryogenesis and plays an essential evolutionarily-conserved role during neuronal development.

Pssm-ID: 350600 Cd Length: 95 Bit Score: 41.99 E-value: 7.56e-05

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 33354238 177 ETVRQSEDFNSLSRDTLLDLISRDELETEdERVVFEAILQWVkhDLEQRKAHLPLLLRNVRLAL 240
Cdd:cd18525  34 ELALKSEGFCEIDQQTLEIILTRETLNTK-EVVVFEAVLNWA--EAECKRQGLPPTARNKRNVL 94

PLN02193

nitrile-specifier protein

294-451

8.98e-05

nitrile-specifier protein

Pssm-ID: 177844 [Multi-domain] Cd Length: 470 Bit Score: 45.33 E-value: 8.98e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  294 GHTLLILGGQTF--MCDKIYQVD---HKAKEIIPKADLPSPRKEFSASAIGCKVYVTGGRGSENGVsKDVWVYDTVHEEW 368
Cdd:PLN02193 228 GSTLYVFGGRDAsrQYNGFYSFDtttNEWKLLTPVEEGPTPRSFHSMAADEENVYVFGGVSATARL-KTLDSYNIVDKKW 306

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  369 ---SKAAPMLIARFGHGSAELENCLYVVGGHTslagifpaspSVSLKQVEKYDPGDNKWTMVA-----PMRDGVSNAAVV 440
Cdd:PLN02193 307 fhcSTPGDSFSIRGGAGLEVVQGKVWVVYGFN----------GCEVDDVHYYDPVQDKWTQVEtfgvrPSERSVFASAAV 376

                        170
                 ....*....|.
gi 33354238  441 SAklKLFVFGG 451
Cdd:PLN02193 377 GK--HIVIFGG 385

BTB_POZ_ZBTB12

cd18203

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

23-141

9.76e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 12 (ZBTB12); ZBTB12, also called protein G10, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349512 [Multi-domain] Cd Length: 122 Bit Score: 42.17 E-value: 9.76e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  23 FHKASHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFShgLRESRDDTVNFqdnLH-PEVLELL 101
Cdd:cd18203   3 FQLPGHEAATLRNMNQLRSEERFCDVTIVADSLKFRGHKVVLAACSPFLRDQFL--LNPSSELQVSL---MHsSRVVADL 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 33354238 102 LDFAYSSRIVINEENAESLLEAGDMLQFHDV----RDAAAEFLE 141
Cdd:cd18203  78 LLSCYTGALEFSVRDIVNYLTAASYLQMEHVvekcRGALSQFIE 121

BTB_POZ_ZBTB20_DPZF

cd18208

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

30-142

1.04e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20); ZBTB20, also called dendritic-derived BTB/POZ zinc finger protein (DPZF) or zinc finger protein 288, may be a transcription factor involved in hematopoiesis, oncogenesis, and immune responses. It is an essential regulator of hepatic lipogenesis and may be a therapeutic target for the treatment of fatty liver disease. It also functions as a critical regulator of anterior pituitary development and lactotrope specification. Moreover, it promotes astrocytogenesis during neocortical development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349517 [Multi-domain] Cd Length: 117 Bit Score: 41.97 E-value: 1.04e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  30 DCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVnfqdnLHPEVLELLLDFAYSSR 109
Cdd:cd18208  10 NSVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSDIEIPSV-----VSVQSVQKLIDFMYSGV 84

                        90       100       110
                ....*....|....*....|....*....|...
gi 33354238 110 IVINEENAESLLEAGDMLQFHDVRDAAAEFLEK 142
Cdd:cd18208  85 LRVSQSEALQILTAASILQIKTVIDECTRIVSQ 117

BTB_POZ_BTBD3_6

cd18282

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

58-144

1.55e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This family includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349591 [Multi-domain] Cd Length: 108 Bit Score: 41.23 E-value: 1.55e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  58 PCHRAVLAASSRYFEAMFSHGLRESRDDTVnfQDNLHPEVLELLLDFAYSSRIVINEENA-ESLLEAGDMLQFHDVRdAA 136
Cdd:cd18282  24 PAHKYVLATGSSVFYAMFYGGLAENKNEIE--IPDVEPAAFLNLLRYLYCDEIDLEPDTVlATLYAAKKYLVPHLAR-AC 100


                ....*...
gi 33354238 137 AEFLEKNL 144
Cdd:cd18282 101 VQFLETSL 108

BTB1_POZ_ABTB1_BPOZ1

cd18295

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

44-121

2.51e-04

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349604 [Multi-domain] Cd Length: 119 Bit Score: 41.08 E-value: 2.51e-04

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 33354238  44 MFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHglRESRDDTVNFQDNL-HPEVLELLLDFAYSSRIVINEENAESLL 121
Cdd:cd18295  18 SYSDVTFNVHGESFPAHRCILSARSPYFAEMFET--KWKDKREINLKHPLvNPDAFRALLQYLYTGRLEIHVDDVEDCK 94

PLN02193

nitrile-specifier protein

475-582

3.75e-04

nitrile-specifier protein

Pssm-ID: 177844 [Multi-domain] Cd Length: 470 Bit Score: 43.41 E-value: 3.75e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  475 KAECPQPWRYTAAAVLGSQIFIMGGdtEYTAASA-----YRFDCETNQWT---RIGDMtaKRMSC---HAVASGNKLYVV 543
Cdd:PLN02193 159 KGEGPGLRCSHGIAQVGNKIYSFGG--EFTPNQPidkhlYVFDLETRTWSispATGDV--PHLSClgvRMVSIGSTLYVF 234

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 33354238  544 GGYFGTQRCKTLDCYDPTSDTWNCITTVPYSLIPTAFVS 582
Cdd:PLN02193 235 GGRDASRQYNGFYSFDTTTNEWKLLTPVEEGPTPRSFHS 273

PRK14131

N-acetylneuraminate epimerase;

477-582

4.25e-04

N-acetylneuraminate epimerase;

Pssm-ID: 237617 [Multi-domain] Cd Length: 376 Bit Score: 43.08 E-value: 4.25e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  477 ECPQPWRYTAAAVLGSQIFIMGGDTEytaASAYRFDCET--NQWTRIGDM-TAKRMSCHAVASGNKLYVVGGyFG----- 548
Cdd:PRK14131  24 DLPVPFKNGTGAIDNNTVYVGLGSAG---TSWYKLDLNApsKGWTKIAAFpGGPREQAVAAFIDGKLYVFGG-IGktnse 99

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 33354238  549 --TQRCKTLDCYDPTSDTWNCI-TTVPYSLIPTAFVS 582
Cdd:PRK14131 100 gsPQVFDDVYKYDPKTNSWQKLdTRSPVGLAGHVAVS 136

BACK_KBTBD4

cd18481

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...

148-227

5.25e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also termed BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates.

Pssm-ID: 350556 Cd Length: 88 Bit Score: 39.10 E-value: 5.25e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238 148 NCLGMMVLSDAHQCRRLYEFSCRMSLVHFETVRQSEDFNSLSRDTLLDLISRDELETEDERvvfEAILQWVKHDLEQRKA 227
Cdd:cd18481   5 NCLQVMWLADQHSDQELYTAAKHCAKTHLSQLHQTEEFLNLPLRLLTDIIKDGVPCSQNPT---AAIEAWINHNKEEREG 81

Kelch_5

pfam13854

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

327-363

5.27e-04

Pssm-ID: 433528 [Multi-domain] Cd Length: 41 Bit Score: 37.93 E-value: 5.27e-04

                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 33354238   327 PSPRKEFSASAIGCKVYVTGGR-GSENGVSKDVWVYDT 363
Cdd:pfam13854   1 PVPRYGHCAVTVGDYIYLYGGYtGGEGQPSDDVYVLSL 38

Kelch_3

pfam13415

Galactose oxidase, central domain;

491-535

5.50e-04

Galactose oxidase, central domain;

Pssm-ID: 433188 [Multi-domain] Cd Length: 49 Bit Score: 38.04 E-value: 5.50e-04

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 33354238   491 GSQIFIMGGDTEYTAA---SAYRFDCETNQWTRIGDMTAKRMSCHAVA 535
Cdd:pfam13415   1 GDKLYIFGGLGFDGQTrlnDLYVYDLDTNTWTQIGDLPPPRSGHSATY 48

PLN02153

epithiospecifier protein

479-569

6.26e-04

epithiospecifier protein

Pssm-ID: 177814 [Multi-domain] Cd Length: 341 Bit Score: 42.28 E-value: 6.26e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  479 PQPWRYTAAAVLGSQIFIMGGD---TEYTAASAYRFDCETNQWTRI---GDmtAKRMSC---HAVASGNKLYVVGGYFGT 549
Cdd:PLN02153  20 PGPRCSHGIAVVGDKLYSFGGElkpNEHIDKDLYVFDFNTHTWSIApanGD--VPRISClgvRMVAVGTKLYIFGGRDEK 97

                         90       100
                 ....*....|....*....|
gi 33354238  550 QRCKTLDCYDPTSDTWNCIT 569
Cdd:PLN02153  98 REFSDFYSYDTVKNEWTFLT 117

BACK_KLHL14

cd18453

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 14 (KLHL14); KLHL14, also ...

205-243

8.12e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 14 (KLHL14); KLHL14, also termed protein interactor of Torsin-1A, or Printor, or protein interactor of torsinA, is a novel ATP-free form of torsinA-interacting protein implicated in dystonia pathogenesis.

Pssm-ID: 350528 Cd Length: 102 Bit Score: 39.23 E-value: 8.12e-04

                        10        20        30
                ....*....|....*....|....*....|....*....
gi 33354238 205 EDERVVFEAILQWVKHDLEQRKAHLPLLLRNVRLALLPS 243
Cdd:cd18453  53 ESELALFQMSVLWLEHDRETRMQYAPDLMKRLRFALIPA 91

BACK_KLHL9_13

cd18449

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 ...

173-239

1.14e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 and KLHL13 (also termed BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.

Pssm-ID: 350524 [Multi-domain] Cd Length: 95 Bit Score: 38.56 E-value: 1.14e-03

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 33354238 173 LVHFETVRQSEDFNSLSRDTLLDLISRDELETEDERVVFEAILQWVKHDlEQRKAHLPLLLRNVRLA 239
Cdd:cd18449  30 LKNFPALLSTGDFVKLPFERLAFVLSSNSLKGCTELELFKAACRWLRHE-DDRMQFAAKLMENIRFP 95

Kelch_2

pfam07646

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

528-571

1.47e-03

Pssm-ID: 462220 [Multi-domain] Cd Length: 47 Bit Score: 36.93 E-value: 1.47e-03

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 33354238   528 RMSCHAVAS-GNKLYVVGGYFGTQRCKTLD--CYDPTSDTWNCITTV 571
Cdd:pfam07646   1 PRYPHASSVpGGKLYVVGGSDGLGDLSSSDvlVYDPETNVWTEVPRL 47

Kelch_2

pfam07646

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

481-524

1.50e-03

Pssm-ID: 462220 [Multi-domain] Cd Length: 47 Bit Score: 36.55 E-value: 1.50e-03

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 33354238   481 PWRYTAAAVLGSQIFIMGGDTEYTAAS---AYRFDCETNQWTRIGDM 524
Cdd:pfam07646   1 PRYPHASSVPGGKLYVVGGSDGLGDLSssdVLVYDPETNVWTEVPRL 47

BTB_POZ_BTBD6

cd18349

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

53-144

1.64e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 6 (BTBD6); BTBD6, also termed lens BTB domain protein, is a BTB-domain-containing Kelch-like protein required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349658 [Multi-domain] Cd Length: 109 Bit Score: 38.43 E-value: 1.64e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238  53 GDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDtVNFQDnLHPEVLELLLDFAYSSRIVINEENAESLLEAGDMLQFHDV 132
Cdd:cd18349  20 ASQRVPAHKYVLAVGSSVFYAMFYGDLAEVKSE-IHIPD-VEPAAFLILLKYMYSDEIDLEADTVLATLYAAKKYIVPAL 97

                        90
                ....*....|..
gi 33354238 133 RDAAAEFLEKNL 144
Cdd:cd18349  98 AKACVNFLETSL 109

Kelch_1

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

435-479

1.78e-03

Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 36.44 E-value: 1.78e-03

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 33354238   435 SNAAVVSAKLKLFVFGGtSIHRDMVSKVQCFDPSENRWTIKAECP 479
Cdd:pfam01344   3 SGAGVVVVGGKIYVIGG-FDGNQSLNSVEVYDPETNTWSKLPSMP 46

BACK_KBTBD6_7

cd18482

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing ...

144-237

1.99e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing proteins, KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling.

Pssm-ID: 350557 [Multi-domain] Cd Length: 99 Bit Score: 37.87 E-value: 1.99e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238 144 LSPSNCLGMMVLSDAHQCRRLYEFSCRMSLVHFET-VRQSEDFNSLSRDTLLDLISRDELETEDERVVFEAILQWVKHDL 222
Cdd:cd18482   1 LDLSNCAGILKFADAFDNRELKSKALAFIARNFQQlLAKEEELCELSLAQLKEVLMLDSLDVDSERKVCSVAVQWIEANL 80

                        90
                ....*....|....*
gi 33354238 223 EQRKAHLPLLLRNVR 237
Cdd:cd18482  81 KERAASAAEVLKCVR 95

BACK_KLHL22

cd18461

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a ...

148-241

2.23e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of Polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation.

Pssm-ID: 350536 Cd Length: 104 Bit Score: 37.82 E-value: 2.23e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33354238 148 NCLGMMVLSDAHQCRRLYEFSCRMSLVHFETVRQSEDFNSLSRDTLLDLISRDELETEDERVVFEAIL--QWVKHDLEQR 225
Cdd:cd18461   5 NILDVYKLADLFHLTHLSEQLDSYILKNFPTFSRTETYRQLPLEKVYSLLSSNRLEVDSENEVYEGALlyHYTPEQVEKD 84

                        90
                ....*....|....*....
gi 33354238 226 KAHL---PLLLRNVRLALL 241
Cdd:cd18461  85 QVSLqepPKLLEAVRFPLM 103

Kelch_4

pfam13418

Galactose oxidase, central domain;

528-573

2.40e-03

Galactose oxidase, central domain;

Pssm-ID: 433191 [Multi-domain] Cd Length: 49 Bit Score: 36.05 E-value: 2.40e-03

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 33354238   528 RMSCHAVASGN-KLYVVGGYFG-TQRCKTLDCYDPTSDTWNCITTVPY 573
Cdd:pfam13418   2 RAYHTSTSIPDdTIYLFGGEGEdGTLLSDLWVFDLSTNEWTRLGSLPS 49

BTB2_POZ_RHOBTB1

cd18358

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

41-115

2.62e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1); RhoBTB1 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB1 functions as a tumor suppressor that regulates the integrity of the Golgi complex through the methyltransferase METTL7B. It also acts an adaptor of the Cullin-3-dependent E3 ubiquitin ligase complex. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349667 [Multi-domain] Cd Length: 126 Bit Score: 38.41 E-value: 2.62e-03

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 33354238  41 KHCM----FTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQdNLHPEVLELLLDFAYSSRIVINEE 115
Cdd:cd18358  12 KECLskgtFSDVTFKLDDGTINAHKPLLICSCEWMAAMFGGSFIESANSEVVLP-NISKVSMQAVLDYLYTKQLSPTAD 89

Kelch_6

pfam13964

Kelch motif;

377-431

4.00e-03

Kelch motif;

Pssm-ID: 404790 [Multi-domain] Cd Length: 50 Bit Score: 35.77 E-value: 4.00e-03

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 33354238   377 ARFGHGSAELENCLYVVGGHTSlagifpasPSVSLKQVEKYDPGDNKWTMVAPMR 431
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYTN--------ASPALNKLEVYNPLTKSWEELPPLP 47

Kelch