R3H domain-containing protein 1 [Mus musculus]
Protein Classification
List of domain hits
| Name | Accession | Description | Interval | E-value | ||||||
| R3H_encore_like | cd02642 | R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the ... |
167-228 | 1.34e-26 | ||||||
R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H domain is a potential regulator of DBF1 activity in stress responses. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to bind ssDNA or ssRNA in a sequence-specific manner. : Pssm-ID: 100071 Cd Length: 63 Bit Score: 103.45 E-value: 1.34e-26
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| SUZ | pfam12752 | SUZ domain; The SUZ domain is a conserved RNA-binding domain found in eukaryotes and enriched ... |
251-302 | 2.27e-12 | ||||||
SUZ domain; The SUZ domain is a conserved RNA-binding domain found in eukaryotes and enriched in positively charged amino acids. It was first characterized in the C.elegans protein Szy-20 where it has been shown to bind RNA and allow their localization to the centrosome. Warning- the domain has a compositionally biased character. : Pssm-ID: 463689 [Multi-domain] Cd Length: 56 Bit Score: 62.72 E-value: 2.27e-12
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| Atrophin-1 super family | cl38111 | Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
535-860 | 1.15e-03 | ||||||
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity. The actual alignment was detected with superfamily member pfam03154: Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 43.22 E-value: 1.15e-03
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| Name | Accession | Description | Interval | E-value | ||||||
| R3H_encore_like | cd02642 | R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the ... |
167-228 | 1.34e-26 | ||||||
R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H domain is a potential regulator of DBF1 activity in stress responses. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to bind ssDNA or ssRNA in a sequence-specific manner. Pssm-ID: 100071 Cd Length: 63 Bit Score: 103.45 E-value: 1.34e-26
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| R3H | smart00393 | Putative single-stranded nucleic acids-binding domain; |
151-228 | 7.13e-18 | ||||||
Putative single-stranded nucleic acids-binding domain; Pssm-ID: 214647 Cd Length: 79 Bit Score: 79.27 E-value: 7.13e-18
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| SUZ | pfam12752 | SUZ domain; The SUZ domain is a conserved RNA-binding domain found in eukaryotes and enriched ... |
251-302 | 2.27e-12 | ||||||
SUZ domain; The SUZ domain is a conserved RNA-binding domain found in eukaryotes and enriched in positively charged amino acids. It was first characterized in the C.elegans protein Szy-20 where it has been shown to bind RNA and allow their localization to the centrosome. Warning- the domain has a compositionally biased character. Pssm-ID: 463689 [Multi-domain] Cd Length: 56 Bit Score: 62.72 E-value: 2.27e-12
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| R3H | pfam01424 | R3H domain; The name of the R3H domain comes from the characteriztic spacing of the most ... |
169-227 | 1.48e-11 | ||||||
R3H domain; The name of the R3H domain comes from the characteriztic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to be binding ssDNA. Pssm-ID: 460206 Cd Length: 60 Bit Score: 60.58 E-value: 1.48e-11
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| Atrophin-1 | pfam03154 | Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
535-860 | 1.15e-03 | ||||||
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity. Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 43.22 E-value: 1.15e-03
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| Name | Accession | Description | Interval | E-value | ||||||
| R3H_encore_like | cd02642 | R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the ... |
167-228 | 1.34e-26 | ||||||
R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H domain is a potential regulator of DBF1 activity in stress responses. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to bind ssDNA or ssRNA in a sequence-specific manner. Pssm-ID: 100071 Cd Length: 63 Bit Score: 103.45 E-value: 1.34e-26
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| R3H | smart00393 | Putative single-stranded nucleic acids-binding domain; |
151-228 | 7.13e-18 | ||||||
Putative single-stranded nucleic acids-binding domain; Pssm-ID: 214647 Cd Length: 79 Bit Score: 79.27 E-value: 7.13e-18
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| SUZ | pfam12752 | SUZ domain; The SUZ domain is a conserved RNA-binding domain found in eukaryotes and enriched ... |
251-302 | 2.27e-12 | ||||||
SUZ domain; The SUZ domain is a conserved RNA-binding domain found in eukaryotes and enriched in positively charged amino acids. It was first characterized in the C.elegans protein Szy-20 where it has been shown to bind RNA and allow their localization to the centrosome. Warning- the domain has a compositionally biased character. Pssm-ID: 463689 [Multi-domain] Cd Length: 56 Bit Score: 62.72 E-value: 2.27e-12
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| R3H | pfam01424 | R3H domain; The name of the R3H domain comes from the characteriztic spacing of the most ... |
169-227 | 1.48e-11 | ||||||
R3H domain; The name of the R3H domain comes from the characteriztic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to be binding ssDNA. Pssm-ID: 460206 Cd Length: 60 Bit Score: 60.58 E-value: 1.48e-11
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| R3H | cd02325 | R3H domain. The name of the R3H domain comes from the characteristic spacing of the most ... |
171-227 | 3.66e-11 | ||||||
R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich repeats, ring-type zinc fingers, and KH domains. The function of the domain is predicted to bind ssDNA or ssRNA in a sequence-specific manner. Pssm-ID: 100064 Cd Length: 59 Bit Score: 59.55 E-value: 3.66e-11
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| Atrophin-1 | pfam03154 | Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
535-860 | 1.15e-03 | ||||||
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity. Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 43.22 E-value: 1.15e-03
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| Blast search parameters | ||||
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