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Conserved domains on  [gi|294774572|ref|NP_859051|]
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serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform c [Homo sapiens]

Protein Classification

HEAT repeat domain-containing protein( domain architecture ID 11444369)

HEAT repeat domain-containing protein may function as a scaffold, anchoring and/or adaptor protein

CATH:  1.25.10.10
Gene Ontology:  GO:0005515
PubMed:  35552740|10378263
SCOP:  4001283

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
HEAT COG1413
HEAT repeat [General function prediction only];
129-300 4.04e-08

HEAT repeat [General function prediction only];


:

Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 52.32  E-value: 4.04e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294774572 129 VRRAAASKLGEFAKvleldsvkSEIVPLFTSLASDEQDSVRLLAVEAcvsIAQLLSQDDLETLVmptlrQAAEDKSWRVR 208
Cdd:COG1413    1 VRRAAARALGRLGD--------PAAVPALIAALADEDPDVRAAAARA---LGRLGDPRAVPALL-----EALKDPDPEVR 64

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294774572 209 YMVADrfselqkAMGpKITLNDLIPAFQNLLKDCEAEVRAAAAHKVKELGEnlpiedretiimNQILPYIKELVSDTNQH 288
Cdd:COG1413   65 AAAAE-------ALG-RIGDPEAVPALIAALKDEDPEVRRAAAEALGRLGD------------PAAVPALLEALKDPDWE 124

                        170
                 ....*....|..
gi 294774572 289 VKSALASVIMGL 300
Cdd:COG1413  125 VRRAAARALGRL 136
HEAT COG1413
HEAT repeat [General function prediction only];
26-175 1.19e-06

HEAT repeat [General function prediction only];


:

Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 48.09  E-value: 1.19e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294774572  26 AVLIDELRNEDVQPPLENLATVEETVVRDKAVESLRQIsqeHTPVALEayfvPLVKRLASGDWFTSRTSACGLFSVCYPR 105
Cdd:COG1413    6 ARALGRLGDPAAVPALIAALADEDPDVRAAAARALGRL---GDPRAVP----ALLEALKDPDPEVRAAAAEALGRIGDPE 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294774572 106 ASNAVKAeirqqfrsLCSDDTPMVRRAAASKLGEFAKVleldsvksEIVPLFTSLASDEQDSVRLLAVEA 175
Cdd:COG1413   79 AVPALIA--------ALKDEDPEVRRAAAEALGRLGDP--------AAVPALLEALKDPDWEVRRAAARA 132
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 314-414 4.55e-03

HEAT repeats; This family includes multiple HEAT repeats.


:

Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 36.55  E-value: 4.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294774572  314 LPLFLAQL-KDECPDVRLNIIsnldcvnEVIGiRQLSQSLLPAIVELAEDAKWRVRLAIIEYMpllaGQLGVEffdEKLN 392
Cdd:pfam13646   1 LPALLQALlRDPDPEVRAAAI-------RALG-RIGDPEAVPALLELLKDEDPAVRRAAAEAL----GKIGDP---EALP 65

                          90       100
                  ....*....|....*....|..
gi 294774572  393 SLCMAWLVDHVYAIREAATNNL 414
Cdd:pfam13646  66 ALLELLRDDDDDVVRAAAAEAL 87
 
Name Accession Description Interval E-value
HEAT COG1413
HEAT repeat [General function prediction only];
129-300 4.04e-08

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 52.32  E-value: 4.04e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294774572 129 VRRAAASKLGEFAKvleldsvkSEIVPLFTSLASDEQDSVRLLAVEAcvsIAQLLSQDDLETLVmptlrQAAEDKSWRVR 208
Cdd:COG1413    1 VRRAAARALGRLGD--------PAAVPALIAALADEDPDVRAAAARA---LGRLGDPRAVPALL-----EALKDPDPEVR 64

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294774572 209 YMVADrfselqkAMGpKITLNDLIPAFQNLLKDCEAEVRAAAAHKVKELGEnlpiedretiimNQILPYIKELVSDTNQH 288
Cdd:COG1413   65 AAAAE-------ALG-RIGDPEAVPALIAALKDEDPEVRRAAAEALGRLGD------------PAAVPALLEALKDPDWE 124

                        170
                 ....*....|..
gi 294774572 289 VKSALASVIMGL 300
Cdd:COG1413  125 VRRAAARALGRL 136
HEAT COG1413
HEAT repeat [General function prediction only];
26-175 1.19e-06

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 48.09  E-value: 1.19e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294774572  26 AVLIDELRNEDVQPPLENLATVEETVVRDKAVESLRQIsqeHTPVALEayfvPLVKRLASGDWFTSRTSACGLFSVCYPR 105
Cdd:COG1413    6 ARALGRLGDPAAVPALIAALADEDPDVRAAAARALGRL---GDPRAVP----ALLEALKDPDPEVRAAAAEALGRIGDPE 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294774572 106 ASNAVKAeirqqfrsLCSDDTPMVRRAAASKLGEFAKVleldsvksEIVPLFTSLASDEQDSVRLLAVEA 175
Cdd:COG1413   79 AVPALIA--------ALKDEDPEVRRAAAEALGRLGDP--------AAVPALLEALKDPDWEVRRAAARA 132
PRK13800 PRK13800
fumarate reductase/succinate dehydrogenase flavoprotein subunit;
123-258 1.21e-05

fumarate reductase/succinate dehydrogenase flavoprotein subunit;


Pssm-ID: 237512 [Multi-domain]  Cd Length: 897  Bit Score: 48.31  E-value: 1.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294774572 123 SDDTPMVRRAAASKLGEFAKVLE--------LDS----VKSEIV-----------PLFTSLASDEQDSVRLLAVEACVSI 179
Cdd:PRK13800 662 GDGAAAVRRAAAEGLRELVEVLPpapalrdhLGSpdpvVRAAALdvlralragdaALFAAALGDPDHRVRIEAVRALVSV 741

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 294774572 180 aqllsqDDLETLVMptlrqAAEDKSWRVRYMVADRFSELQKAMGPKitlndlIPAFQNLLKDCEAEVRAAAAHKVKELG 258
Cdd:PRK13800 742 ------DDVESVAG-----AATDENREVRIAVAKGLATLGAGGAPA------GDAVRALTGDPDPLVRAAALAALAELG 803
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 153-252 2.04e-05

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 43.10  E-value: 2.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294774572  153 IVPLFTSLASDEQDSVRLLAVEAcvsIAQLLSQDdletlVMPTLRQAAEDKSWRVRYMVAdrfselqKAMGpKITLNDLI 232
Cdd:pfam13646   1 LPALLQALLRDPDPEVRAAAIRA---LGRIGDPE-----AVPALLELLKDEDPAVRRAAA-------EALG-KIGDPEAL 64

                          90       100
                  ....*....|....*....|.
gi 294774572  233 PAFQNLLKDCEAE-VRAAAAH 252
Cdd:pfam13646  65 PALLELLRDDDDDvVRAAAAE 85
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 314-414 4.55e-03

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 36.55  E-value: 4.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294774572  314 LPLFLAQL-KDECPDVRLNIIsnldcvnEVIGiRQLSQSLLPAIVELAEDAKWRVRLAIIEYMpllaGQLGVEffdEKLN 392
Cdd:pfam13646   1 LPALLQALlRDPDPEVRAAAI-------RALG-RIGDPEAVPALLELLKDEDPAVRRAAAEAL----GKIGDP---EALP 65

                          90       100
                  ....*....|....*....|..
gi 294774572  393 SLCMAWLVDHVYAIREAATNNL 414
Cdd:pfam13646  66 ALLELLRDDDDDVVRAAAAEAL 87
HEAT COG1413
HEAT repeat [General function prediction only];
304-456 7.59e-03

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 37.30  E-value: 7.59e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294774572 304 LGKENTIEHLLPLflaqLKDECPDVRLNIISNLdcvnEVIGirqlSQSLLPAIVELAEDAKWRVRLAIIEYMpllaGQLG 383
Cdd:COG1413   12 LGDPAAVPALIAA----LADEDPDVRAAAARAL----GRLG----DPRAVPALLEALKDPDPEVRAAAAEAL----GRIG 75

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 294774572 384 veffDEKLNSLCMAWLVDHVYAIREAATNNLmklvQKFGTEWAqntiVPKVLVMANDPNYLHRMTTLFCINAL 456
Cdd:COG1413   76 ----DPEAVPALIAALKDEDPEVRRAAAEAL----GRLGDPAA----VPALLEALKDPDWEVRRAAARALGRL 136
 
Name Accession Description Interval E-value
HEAT COG1413
HEAT repeat [General function prediction only];
129-300 4.04e-08

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 52.32  E-value: 4.04e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294774572 129 VRRAAASKLGEFAKvleldsvkSEIVPLFTSLASDEQDSVRLLAVEAcvsIAQLLSQDDLETLVmptlrQAAEDKSWRVR 208
Cdd:COG1413    1 VRRAAARALGRLGD--------PAAVPALIAALADEDPDVRAAAARA---LGRLGDPRAVPALL-----EALKDPDPEVR 64

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294774572 209 YMVADrfselqkAMGpKITLNDLIPAFQNLLKDCEAEVRAAAAHKVKELGEnlpiedretiimNQILPYIKELVSDTNQH 288
Cdd:COG1413   65 AAAAE-------ALG-RIGDPEAVPALIAALKDEDPEVRRAAAEALGRLGD------------PAAVPALLEALKDPDWE 124

                        170
                 ....*....|..
gi 294774572 289 VKSALASVIMGL 300
Cdd:COG1413  125 VRRAAARALGRL 136
HEAT COG1413
HEAT repeat [General function prediction only];
26-175 1.19e-06

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 48.09  E-value: 1.19e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294774572  26 AVLIDELRNEDVQPPLENLATVEETVVRDKAVESLRQIsqeHTPVALEayfvPLVKRLASGDWFTSRTSACGLFSVCYPR 105
Cdd:COG1413    6 ARALGRLGDPAAVPALIAALADEDPDVRAAAARALGRL---GDPRAVP----ALLEALKDPDPEVRAAAAEALGRIGDPE 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294774572 106 ASNAVKAeirqqfrsLCSDDTPMVRRAAASKLGEFAKVleldsvksEIVPLFTSLASDEQDSVRLLAVEA 175
Cdd:COG1413   79 AVPALIA--------ALKDEDPEVRRAAAEALGRLGDP--------AAVPALLEALKDPDWEVRRAAARA 132
PRK13800 PRK13800
fumarate reductase/succinate dehydrogenase flavoprotein subunit;
123-258 1.21e-05

fumarate reductase/succinate dehydrogenase flavoprotein subunit;


Pssm-ID: 237512 [Multi-domain]  Cd Length: 897  Bit Score: 48.31  E-value: 1.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294774572 123 SDDTPMVRRAAASKLGEFAKVLE--------LDS----VKSEIV-----------PLFTSLASDEQDSVRLLAVEACVSI 179
Cdd:PRK13800 662 GDGAAAVRRAAAEGLRELVEVLPpapalrdhLGSpdpvVRAAALdvlralragdaALFAAALGDPDHRVRIEAVRALVSV 741

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 294774572 180 aqllsqDDLETLVMptlrqAAEDKSWRVRYMVADRFSELQKAMGPKitlndlIPAFQNLLKDCEAEVRAAAAHKVKELG 258
Cdd:PRK13800 742 ------DDVESVAG-----AATDENREVRIAVAKGLATLGAGGAPA------GDAVRALTGDPDPLVRAAALAALAELG 803
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 153-252 2.04e-05

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 43.10  E-value: 2.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294774572  153 IVPLFTSLASDEQDSVRLLAVEAcvsIAQLLSQDdletlVMPTLRQAAEDKSWRVRYMVAdrfselqKAMGpKITLNDLI 232
Cdd:pfam13646   1 LPALLQALLRDPDPEVRAAAIRA---LGRIGDPE-----AVPALLELLKDEDPAVRRAAA-------EALG-KIGDPEAL 64

                          90       100
                  ....*....|....*....|.
gi 294774572  233 PAFQNLLKDCEAE-VRAAAAH 252
Cdd:pfam13646  65 PALLELLRDDDDDvVRAAAAE 85
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 121-208 2.14e-03

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 37.70  E-value: 2.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294774572  121 LCSDDTPMVRRAAASKLGEFAKvleldsvkSEIVPLFTSLASDEQDSVRLLAVEACVSIAqllSQDDLETLvmptLRQAA 200
Cdd:pfam13646   8 LLRDPDPEVRAAAIRALGRIGD--------PEAVPALLELLKDEDPAVRRAAAEALGKIG---DPEALPAL----LELLR 72


                  ....*...
gi 294774572  201 EDKSWRVR 208
Cdd:pfam13646  73 DDDDDVVR 80
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 314-414 4.55e-03

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 36.55  E-value: 4.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294774572  314 LPLFLAQL-KDECPDVRLNIIsnldcvnEVIGiRQLSQSLLPAIVELAEDAKWRVRLAIIEYMpllaGQLGVEffdEKLN 392
Cdd:pfam13646   1 LPALLQALlRDPDPEVRAAAI-------RALG-RIGDPEAVPALLELLKDEDPAVRRAAAEAL----GKIGDP---EALP 65

                          90       100
                  ....*....|....*....|..
gi 294774572  393 SLCMAWLVDHVYAIREAATNNL 414
Cdd:pfam13646  66 ALLELLRDDDDDVVRAAAAEAL 87
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 127-176 4.75e-03

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 35.42  E-value: 4.75e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 294774572  127 PMVRRAAASKLGEFAKVLE--LDSVKSEIVPLFTSLASDEQDSVRLLAVEAC 176
Cdd:pfam13513   1 WRVREAAALALGSLAEGGPdlLAPAVPELLPALLPLLNDDSDLVREAAAWAL 52
HEAT pfam02985
HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see ...
 231-261 6.96e-03

HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514).


Pssm-ID: 460773  Cd Length: 31  Bit Score: 34.43  E-value: 6.96e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 294774572  231 LIPAFQNLLKDCEAEVRAAAAHKVKELGENL 261
Cdd:pfam02985   1 LLPLLLKLLNDPSPEVREAAAEALGELAEVL 31
HEAT pfam02985
HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see ...
 114-144 7.24e-03

HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514).


Pssm-ID: 460773  Cd Length: 31  Bit Score: 34.43  E-value: 7.24e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 294774572  114 IRQQFRSLCSDDTPMVRRAAASKLGEFAKVL 144
Cdd:pfam02985   1 LLPLLLKLLNDPSPEVREAAAEALGELAEVL 31
HEAT COG1413
HEAT repeat [General function prediction only];
304-456 7.59e-03

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 37.30  E-value: 7.59e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294774572 304 LGKENTIEHLLPLflaqLKDECPDVRLNIISNLdcvnEVIGirqlSQSLLPAIVELAEDAKWRVRLAIIEYMpllaGQLG 383
Cdd:COG1413   12 LGDPAAVPALIAA----LADEDPDVRAAAARAL----GRLG----DPRAVPALLEALKDPDPEVRAAAAEAL----GRIG 75

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 294774572 384 veffDEKLNSLCMAWLVDHVYAIREAATNNLmklvQKFGTEWAqntiVPKVLVMANDPNYLHRMTTLFCINAL 456
Cdd:COG1413   76 ----DPEAVPALIAALKDEDPEVRRAAAEAL----GRLGDPAA----VPALLEALKDPDWEVRRAAARALGRL 136
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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