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Conserved domains on  [gi|283806707|ref|NP_848497|]
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MARVEL domain-containing protein 2 isoform 2 [Mus musculus]

Protein Classification

ELL and Occludin_ELL domain-containing protein( domain architecture ID 10538136)

ELL and Occludin_ELL domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Occludin_ELL pfam07303
Occludin homology domain; This domain represents a conserved region approximately 100 residues ...
 166-268 1.16e-46

Occludin homology domain; This domain represents a conserved region approximately 100 residues long within eukaryotic occludin proteins and the RNA polymerase II elongation factor ELL. Occludin is an integral membrane protein that localizes to tight junctions, while ELL is an elongation factor that can increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by polymerase at multiple sites along the DNA. This shared domain is thought to mediate protein interactions.


:

Pssm-ID: 462140 [Multi-domain]  Cd Length: 101  Bit Score: 151.53  E-value: 1.16e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283806707  166 YPVIQTDDDRERYKAVFQDQFSEYKELSAEVQAILRKFDELDTVMSRLPHHSEnrQEHERISRIHEEFRKKKNDPSFLEK 245
Cdd:pfam07303   1 YPPITSDEQRQRYKQEFNAEYDEYKELHAELDAVSRKFQKLDRELKSLPEGSK--EYQDIAEEILQEYKKKKKDPEYQEK 78

                          90       100
                  ....*....|....*....|...
gi 283806707  246 KERCDYLKNKLSHIKQRIQEYDK 268
Cdd:pfam07303  79 KKRCEYLHNKLSHIKRLILEYDQ 101
 
Name Accession Description Interval E-value
Occludin_ELL pfam07303
Occludin homology domain; This domain represents a conserved region approximately 100 residues ...
 166-268 1.16e-46

Occludin homology domain; This domain represents a conserved region approximately 100 residues long within eukaryotic occludin proteins and the RNA polymerase II elongation factor ELL. Occludin is an integral membrane protein that localizes to tight junctions, while ELL is an elongation factor that can increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by polymerase at multiple sites along the DNA. This shared domain is thought to mediate protein interactions.


Pssm-ID: 462140 [Multi-domain]  Cd Length: 101  Bit Score: 151.53  E-value: 1.16e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283806707  166 YPVIQTDDDRERYKAVFQDQFSEYKELSAEVQAILRKFDELDTVMSRLPHHSEnrQEHERISRIHEEFRKKKNDPSFLEK 245
Cdd:pfam07303   1 YPPITSDEQRQRYKQEFNAEYDEYKELHAELDAVSRKFQKLDRELKSLPEGSK--EYQDIAEEILQEYKKKKKDPEYQEK 78

                          90       100
                  ....*....|....*....|...
gi 283806707  246 KERCDYLKNKLSHIKQRIQEYDK 268
Cdd:pfam07303  79 KKRCEYLHNKLSHIKRLILEYDQ 101
PRK01156 PRK01156
chromosome segregation protein; Provisional
 170-270 1.30e-03

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 40.27  E-value: 1.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283806707 170 QTDDDreryKAVFQDQFSEYKELSAEVQAILRKFDELDTVMSRLPHHSE--NRQEHE----------------RISRIHE 231
Cdd:PRK01156 205 QIADD----EKSHSITLKEIERLSIEYNNAMDDYNNLKSALNELSSLEDmkNRYESEiktaesdlsmeleknnYYKELEE 280

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 283806707 232 EFRKKKNDPSFLEKKERCDYLKNK---------LSHIKQRIQEYDKVM 270
Cdd:PRK01156 281 RHMKIINDPVYKNRNYINDYFKYKndienkkqiLSNIDAEINKYHAII 328
 
Name Accession Description Interval E-value
Occludin_ELL pfam07303
Occludin homology domain; This domain represents a conserved region approximately 100 residues ...
 166-268 1.16e-46

Occludin homology domain; This domain represents a conserved region approximately 100 residues long within eukaryotic occludin proteins and the RNA polymerase II elongation factor ELL. Occludin is an integral membrane protein that localizes to tight junctions, while ELL is an elongation factor that can increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by polymerase at multiple sites along the DNA. This shared domain is thought to mediate protein interactions.


Pssm-ID: 462140 [Multi-domain]  Cd Length: 101  Bit Score: 151.53  E-value: 1.16e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283806707  166 YPVIQTDDDRERYKAVFQDQFSEYKELSAEVQAILRKFDELDTVMSRLPHHSEnrQEHERISRIHEEFRKKKNDPSFLEK 245
Cdd:pfam07303   1 YPPITSDEQRQRYKQEFNAEYDEYKELHAELDAVSRKFQKLDRELKSLPEGSK--EYQDIAEEILQEYKKKKKDPEYQEK 78

                          90       100
                  ....*....|....*....|...
gi 283806707  246 KERCDYLKNKLSHIKQRIQEYDK 268
Cdd:pfam07303  79 KKRCEYLHNKLSHIKRLILEYDQ 101
PRK01156 PRK01156
chromosome segregation protein; Provisional
 170-270 1.30e-03

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 40.27  E-value: 1.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283806707 170 QTDDDreryKAVFQDQFSEYKELSAEVQAILRKFDELDTVMSRLPHHSE--NRQEHE----------------RISRIHE 231
Cdd:PRK01156 205 QIADD----EKSHSITLKEIERLSIEYNNAMDDYNNLKSALNELSSLEDmkNRYESEiktaesdlsmeleknnYYKELEE 280

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 283806707 232 EFRKKKNDPSFLEKKERCDYLKNK---------LSHIKQRIQEYDKVM 270
Cdd:PRK01156 281 RHMKIINDPVYKNRNYINDYFKYKndienkkqiLSNIDAEINKYHAII 328
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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