NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|29029530|ref|NP_789795|]
View 

sulfotransferase 1C2 isoform b [Homo sapiens]

Protein Classification

sulfotransferase domain-containing protein( domain architecture ID 10464534)

sulfotransferase domain-containing protein such as mammalian sulfotransferases that utilize 3'-phospho-5'-adenylyl sulfate (PAPS) as the sulfonate donor to catalyze the sulfate conjugation of a variety of substrates including catecholamines, phenolic drugs, neurotransmitters, heparan, and estrogen, among others

CATH:  3.40.50.300
EC:  2.8.2.-
Gene Ontology:  GO:0008146
PubMed:  9360604|31270211
SCOP:  4003933

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
39-299 4.89e-108

Sulfotransferase domain;


:

Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 314.28  E-value: 4.89e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029530    39 PDDLLICTYPKAGTTWIQEIVDMIEQNGDVEKCQRAII---QHRHPFIEW--ARPPQPSETGFHHVAQ-AGLKLLSSSNP 112
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLfnnHNRSPFLEWypGDTYFDVAEGPVRLNAlPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029530   113 PastsqsakitDLLPPSFWENNCKFLYVARNAKDCMVSYYHFQRMNHMLPDPGTWEEYFETFINGKVVWGSWFDHVKGWW 192
Cdd:pfam00685  81 L----------HLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWW 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029530   193 EMKDRHQILFLFYEDIKRDPKHEIRKVMQFMGKKVDETVLDKIVQETSFEKMKENPMTNRSTvsksiLDQSISSFMRKGT 272
Cdd:pfam00685 151 KLRPPGNILFLRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSK-----LPKEVSPFFRKGL 225

                         250       260
                  ....*....|....*....|....*..
gi 29029530   273 VGDWKNHFTVAQNERFDEIYRRKMEGT 299
Cdd:pfam00685 226 VGDWKNYFTPEQAEKFDEIYQEKMKGT 252
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
39-299 4.89e-108

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 314.28  E-value: 4.89e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029530    39 PDDLLICTYPKAGTTWIQEIVDMIEQNGDVEKCQRAII---QHRHPFIEW--ARPPQPSETGFHHVAQ-AGLKLLSSSNP 112
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLfnnHNRSPFLEWypGDTYFDVAEGPVRLNAlPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029530   113 PastsqsakitDLLPPSFWENNCKFLYVARNAKDCMVSYYHFQRMNHMLPDPGTWEEYFETFINGKVVWGSWFDHVKGWW 192
Cdd:pfam00685  81 L----------HLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWW 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029530   193 EMKDRHQILFLFYEDIKRDPKHEIRKVMQFMGKKVDETVLDKIVQETSFEKMKENPMTNRSTvsksiLDQSISSFMRKGT 272
Cdd:pfam00685 151 KLRPPGNILFLRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSK-----LPKEVSPFFRKGL 225

                         250       260
                  ....*....|....*....|....*..
gi 29029530   273 VGDWKNHFTVAQNERFDEIYRRKMEGT 299
Cdd:pfam00685 226 VGDWKNYFTPEQAEKFDEIYQEKMKGT 252
PLN02164 PLN02164
sulfotransferase
 35-301 1.11e-32

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 123.49  E-value: 1.11e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029530   35 FEAKPDDLLICTYPKAGTTWIQEIVDMIEQNGDVEKCQRAIIQHR-H---PFIEWARPPQPSetgFHHVAQAGLKLLSSS 110
Cdd:PLN02164  75 FQARPNDFLVCSYPKTGTTWLKALTFAIANRSRFDDSSNPLLKRNpHefvPYIEIDFPFFPS---VDVLKDKGNTLFSTH 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029530  111 NPpastsqsakiTDLLPPSFWENNCKFLYVARNAKDCMVSYYHF-QRMNHMLPDPGTWEEYFETFINGKVVWGSWFDHVK 189
Cdd:PLN02164 152 IP----------YGLLPDSVVKSGCKMVYIWRDPKDTFISMWTFlHKERSQQGPLNSLEESFDMFCRGLSVYGPYLDHVL 221

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029530  190 GWWE--MKDRHQILFLFYEDIKRDPKHEIRKVMQFMG-----KKVDETVLDKIVQETSFEKMK-------ENPMTNRSTV 255
Cdd:PLN02164 222 GYWKayQENPDRILFLKYETMRADPLPYVKRLAEFMGygftaEEEEKGVVEKVVKLCSFETLKnleankgEKDREDRPAV 301

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 29029530  256 SKSildqsiSSFMRKGTVGDWKNHFTVAQNERFDEIYRRKMEGTSI 301
Cdd:PLN02164 302 YAN------SAYFRKGKVGDWQNYLTPEMAARIDGLMEEKFKGTGL 341
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
39-299 4.89e-108

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 314.28  E-value: 4.89e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029530    39 PDDLLICTYPKAGTTWIQEIVDMIEQNGDVEKCQRAII---QHRHPFIEW--ARPPQPSETGFHHVAQ-AGLKLLSSSNP 112
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLfnnHNRSPFLEWypGDTYFDVAEGPVRLNAlPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029530   113 PastsqsakitDLLPPSFWENNCKFLYVARNAKDCMVSYYHFQRMNHMLPDPGTWEEYFETFINGKVVWGSWFDHVKGWW 192
Cdd:pfam00685  81 L----------HLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWW 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029530   193 EMKDRHQILFLFYEDIKRDPKHEIRKVMQFMGKKVDETVLDKIVQETSFEKMKENPMTNRSTvsksiLDQSISSFMRKGT 272
Cdd:pfam00685 151 KLRPPGNILFLRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSK-----LPKEVSPFFRKGL 225

                         250       260
                  ....*....|....*....|....*..
gi 29029530   273 VGDWKNHFTVAQNERFDEIYRRKMEGT 299
Cdd:pfam00685 226 VGDWKNYFTPEQAEKFDEIYQEKMKGT 252
PLN02164 PLN02164
sulfotransferase
 35-301 1.11e-32

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 123.49  E-value: 1.11e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029530   35 FEAKPDDLLICTYPKAGTTWIQEIVDMIEQNGDVEKCQRAIIQHR-H---PFIEWARPPQPSetgFHHVAQAGLKLLSSS 110
Cdd:PLN02164  75 FQARPNDFLVCSYPKTGTTWLKALTFAIANRSRFDDSSNPLLKRNpHefvPYIEIDFPFFPS---VDVLKDKGNTLFSTH 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029530  111 NPpastsqsakiTDLLPPSFWENNCKFLYVARNAKDCMVSYYHF-QRMNHMLPDPGTWEEYFETFINGKVVWGSWFDHVK 189
Cdd:PLN02164 152 IP----------YGLLPDSVVKSGCKMVYIWRDPKDTFISMWTFlHKERSQQGPLNSLEESFDMFCRGLSVYGPYLDHVL 221

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029530  190 GWWE--MKDRHQILFLFYEDIKRDPKHEIRKVMQFMG-----KKVDETVLDKIVQETSFEKMK-------ENPMTNRSTV 255
Cdd:PLN02164 222 GYWKayQENPDRILFLKYETMRADPLPYVKRLAEFMGygftaEEEEKGVVEKVVKLCSFETLKnleankgEKDREDRPAV 301

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 29029530  256 SKSildqsiSSFMRKGTVGDWKNHFTVAQNERFDEIYRRKMEGTSI 301
Cdd:PLN02164 302 YAN------SAYFRKGKVGDWQNYLTPEMAARIDGLMEEKFKGTGL 341
Sulfotransfer_3 pfam13469
Sulfotransferase family;
48-224 1.76e-04

Sulfotransferase family;


Pssm-ID: 463887  Cd Length: 173  Bit Score: 41.51  E-value: 1.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029530    48 PKAGTTWIQEIVD-------MIEQNGDVEKCqRAIIQHRHPFIEW-ARPPQPSETGF----HHVAQAGLkllsssnppas 115
Cdd:pfam13469   7 PRSGTTLLHRLLAahpdvrpPEETWFVIPRI-LALLQAWGKSLEAlARVPSYARWLCdkspSHLFHLDL----------- 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29029530   116 tsqsakITDLLPpsfwenNCKFLYVARNAKDCMVSyyhfQRMNHMLPDPGTWEEYFETFINGKVVWgsWFDHVKGWWEMK 195
Cdd:pfam13469  75 ------LLKAFP------DAKFIHLHRDPVDTVIS----SYCSLFGFTLSSYSTAFLRDIGLALAR--WSRAYERLMAAR 136

                         170       180       190
                  ....*....|....*....|....*....|..
gi 29029530   196 DRH---QILFLFYEDIKRDPKHEIRKVMQFMG 224
Cdd:pfam13469 137 ARVppgRFLDVRYEDLVADPEGTLRRILEFLG 168
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH