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Conserved domains on  [gi|33636746|ref|NP_780622|]
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leucine-rich repeat-containing protein 39 isoform 2 [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
74-280 1.98e-43

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 154.71  E-value: 1.98e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636746  74 TLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQHLIVLDLSRNTISEIPRGIGLLTRLQELILSYNKIKTVPKELSNCTS 153
Cdd:COG4886  81 LLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTN 160

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636746 154 LEKLELAVNRdISDLPPELSKLLKLTHLDLSMNQFTTIPHAVLDMPALEWLDMGSNSLQQLPDSLDRMRSLHTLWLQRNE 233
Cdd:COG4886 161 LKSLDLSNNQ-LTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQ 239

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 33636746 234 ITCLPEtIKNMKNLGTLVLSNNKLQDIPGCMeEMTNLRFVNFRDNPL 280
Cdd:COG4886 240 LTDLPE-LGNLTNLEELDLSNNQLTDLPPLA-NLTNLKTLDLSNNQL 284
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
74-280 1.98e-43

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 154.71  E-value: 1.98e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636746  74 TLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQHLIVLDLSRNTISEIPRGIGLLTRLQELILSYNKIKTVPKELSNCTS 153
Cdd:COG4886  81 LLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTN 160

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636746 154 LEKLELAVNRdISDLPPELSKLLKLTHLDLSMNQFTTIPHAVLDMPALEWLDMGSNSLQQLPDSLDRMRSLHTLWLQRNE 233
Cdd:COG4886 161 LKSLDLSNNQ-LTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQ 239

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 33636746 234 ITCLPEtIKNMKNLGTLVLSNNKLQDIPGCMeEMTNLRFVNFRDNPL 280
Cdd:COG4886 240 LTDLPE-LGNLTNLEELDLSNNQLTDLPPLA-NLTNLKTLDLSNNQL 284
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 77-290 7.51e-23

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 99.54  E-value: 7.51e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636746   77 SSLLKLNQLQEWQLHRTGllKIPEFIGRFQHLIVLDLSRNTIS-EIPRGIGLLTRLQELILSYNKIKT-VPKELSNCTSL 154
Cdd:PLN00113 329 TSLPRLQVLQLWSNKFSG--EIPKNLGKHNNLTVLDLSTNNLTgEIPEGLCSSGNLFKLILFSNSLEGeIPKSLGACRSL 406

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636746  155 EKLELAVNRDISDLPPELSKLLKLTHLDLSMNQFT-TIPHAVLDMPALEWLDMGSNS-LQQLPDSLdRMRSLHTLWLQRN 232
Cdd:PLN00113 407 RRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQgRINSRKWDMPSLQMLSLARNKfFGGLPDSF-GSKRLENLDLSRN 485

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636746  233 EIT-CLPETIKNMKNLGTLVLSNNKLQ-DIPGCMEEMTNLRFVNFRDNPLRLEVTLPPSD 290
Cdd:PLN00113 486 QFSgAVPRKLGSLSELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQLSGQIPASFSE 545
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 90-280 2.75e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 59.41  E-value: 2.75e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636746  90 LHRTGLLKIPEFIgRFQHLIVLDLSRNTISEIPrGIGLLTRLQELILSYNKIKTVPkELSNCTSLEKLELAVNRdISDLp 169
Cdd:cd21340   9 LNDKNITKIDNLS-LCKNLKVLYLYDNKITKIE-NLEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGGNR-ISVV- 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636746 170 pE-LSKLLKLTHLDLSmNQfttiphavlDMPALEWLDMGSNSLQQLpdsldrMRSLHTLWLQRNEITCLpETIKNMKNLG 248
Cdd:cd21340  84 -EgLENLTNLEELHIE-NQ---------RLPPGEKLTFDPRSLAAL------SNSLRVLNISGNNIDSL-EPLAPLRNLE 145

                       170       180       190
                ....*....|....*....|....*....|....*
gi 33636746 249 TLVLSNNKLQDIP---GCMEEMTNLRFVNFRDNPL 280
Cdd:cd21340 146 QLDASNNQISDLEellDLLSSWPSLRELDLTGNPV 180
LRR_8 pfam13855
Leucine rich repeat;
152-211 1.86e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.74  E-value: 1.86e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 33636746   152 TSLEKLELAVNRdISDLPPE-LSKLLKLTHLDLSMNQFTTI-PHAVLDMPALEWLDMGSNSL 211
Cdd:pfam13855   1 PNLRSLDLSNNR-LTSLDDGaFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
74-280 1.98e-43

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 154.71  E-value: 1.98e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636746  74 TLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQHLIVLDLSRNTISEIPRGIGLLTRLQELILSYNKIKTVPKELSNCTS 153
Cdd:COG4886  81 LLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTN 160

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636746 154 LEKLELAVNRdISDLPPELSKLLKLTHLDLSMNQFTTIPHAVLDMPALEWLDMGSNSLQQLPDSLDRMRSLHTLWLQRNE 233
Cdd:COG4886 161 LKSLDLSNNQ-LTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQ 239

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 33636746 234 ITCLPEtIKNMKNLGTLVLSNNKLQDIPGCMeEMTNLRFVNFRDNPL 280
Cdd:COG4886 240 LTDLPE-LGNLTNLEELDLSNNQLTDLPPLA-NLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
73-313 2.40e-35

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 132.75  E-value: 2.40e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636746  73 KTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQHLIVLDLSRNTISEIPRGIGLLTRLQELILSYNKIKTVPKELSNCT 152
Cdd:COG4886 126 TDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLT 205

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636746 153 SLEKLELAVNRdISDLPPELSKLLKLTHLDLSMNQFTTIPhAVLDMPALEWLDMGSNSLQQLPDSLDrMRSLHTLWLQRN 232
Cdd:COG4886 206 NLEELDLSGNQ-LTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPLAN-LTNLKTLDLSNN 282

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636746 233 EITCLpetikNMKNLGTLVLSNNKLQDIPGCMEEMTNLRFvNFRDNPLRLEVTLPPSDNTDGEEEQELFGLQFMHAYIQE 312
Cdd:COG4886 283 QLTDL-----KLKELELLLGLNSLLLLLLLLNLLELLILL-LLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLL 356


                .
gi 33636746 313 S 313
Cdd:COG4886 357 N 357
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
75-281 1.65e-31

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 122.35  E-value: 1.65e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636746  75 LPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQHLIVLDLSRNTISEIPRGIGLLTRLQELILSYNKiktvpkELSNCTSL 154
Cdd:COG4886  42 LLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE------ELSNLTNL 115

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636746 155 EKLELAVNRdISDLPPELSKLLKLTHLDLSMNQFTTIPHAVLDMPALEWLDMGSNSLQQLPDSLDRMRSLHTLWLQRNEI 234
Cdd:COG4886 116 ESLDLSGNQ-LTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQI 194

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 33636746 235 TCLPETIKNMKNLGTLVLSNNKLQDIPGCMEEMTNLRFVNFRDNPLR 281
Cdd:COG4886 195 TDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLT 241
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 77-290 7.51e-23

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 99.54  E-value: 7.51e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636746   77 SSLLKLNQLQEWQLHRTGllKIPEFIGRFQHLIVLDLSRNTIS-EIPRGIGLLTRLQELILSYNKIKT-VPKELSNCTSL 154
Cdd:PLN00113 329 TSLPRLQVLQLWSNKFSG--EIPKNLGKHNNLTVLDLSTNNLTgEIPEGLCSSGNLFKLILFSNSLEGeIPKSLGACRSL 406

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636746  155 EKLELAVNRDISDLPPELSKLLKLTHLDLSMNQFT-TIPHAVLDMPALEWLDMGSNS-LQQLPDSLdRMRSLHTLWLQRN 232
Cdd:PLN00113 407 RRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQgRINSRKWDMPSLQMLSLARNKfFGGLPDSF-GSKRLENLDLSRN 485

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636746  233 EIT-CLPETIKNMKNLGTLVLSNNKLQ-DIPGCMEEMTNLRFVNFRDNPLRLEVTLPPSD 290
Cdd:PLN00113 486 QFSgAVPRKLGSLSELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQLSGQIPASFSE 545
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
73-293 1.01e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 92.30  E-value: 1.01e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636746  73 KTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQHLIVLDLSRNTISEIPRGIGLLTRLQELILSYNKIKTVPkELSNCT 152
Cdd:COG4886 172 TDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLT 250

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636746 153 SLEKLELAVNRdISDLPPeLSKLLKLTHLDLSMNQFTTIPHAVLDMPALEWLDMGSNSLQQLPDSLDRMRSLHTLWLQRN 232
Cdd:COG4886 251 NLEELDLSNNQ-LTDLPP-LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLL 328

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 33636746 233 EITCLPETIKNMKNLGTLVLSNNKLQDIPGCMEEMTNLRFVNFRDNPLRLEVTLPPSDNTD 293
Cdd:COG4886 329 LLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTL 389
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
108-280 5.54e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.21  E-value: 5.54e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636746 108 LIVLDLSRNTISEIPRGIGLLTRLQELILSYNKIKTVPKELSNCTSLEKLELAVNRDISDLPPELSKLLKLTH------- 180
Cdd:COG4886  28 LLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTEldlsgne 107

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636746 181 ----------LDLSMNQFTTIPHAVLDMPALEWLDMGSNSLQQLPDSLDRMRSLHTLWLQRNEITCLPETIKNMKNLGTL 250
Cdd:COG4886 108 elsnltnlesLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKEL 187

                       170       180       190
                ....*....|....*....|....*....|
gi 33636746 251 VLSNNKLQDIPGCMEEMTNLRFVNFRDNPL 280
Cdd:COG4886 188 DLSNNQITDLPEPLGNLTNLEELDLSGNQL 217
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 97-284 3.20e-17

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 82.59  E-value: 3.20e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636746   97 KIPEFIGRFQHLIVLDLSRNTIS-EIPRGIGLLTRLQELILSYNK-IKTVPKELSNCTSLEKLELAVNRDISDLPPELSK 174
Cdd:PLN00113 155 EIPNDIGSFSSLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQlVGQIPRELGQMKSLKWIYLGYNNLSGEIPYEIGG 234

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636746  175 LLKLTHLDLSMNQFT-TIPHAVLDMPALEWLDMGSNSLQ-QLPDSLDRMRSLHTLWLQRNEITC-LPETIKNMKNLGTLV 251
Cdd:PLN00113 235 LTSLNHLDLVYNNLTgPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSGeIPELVIQLQNLEILH 314

                        170       180       190
                 ....*....|....*....|....*....|....
gi 33636746  252 L-SNNKLQDIPGCMEEMTNLRFVNFRDNPLRLEV 284
Cdd:PLN00113 315 LfSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEI 348
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 97-280 3.68e-16

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 79.51  E-value: 3.68e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636746   97 KIPEFIGRFQHLIVLDLSRNT-ISEIPRGIGLLTRLQELILSYNKIK-TVPKELSNCTSLEKLELAVNRDISDLPPELSK 174
Cdd:PLN00113 179 KIPNSLTNLTSLEFLTLASNQlVGQIPRELGQMKSLKWIYLGYNNLSgEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGN 258

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636746  175 LLKLTHLDLSMNQFT-TIPHAVLDMPALEWLDMGSNSLQ-QLPDSLDRMRSLHTLWLQRNEITC-LPETIKNMKNLGTLV 251
Cdd:PLN00113 259 LKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSgEIPELVIQLQNLEILHLFSNNFTGkIPVALTSLPRLQVLQ 338

                        170       180       190
                 ....*....|....*....|....*....|
gi 33636746  252 LSNNKLQ-DIPGCMEEMTNLRFVNFRDNPL 280
Cdd:PLN00113 339 LWSNKFSgEIPKNLGKHNNLTVLDLSTNNL 368
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 108-284 6.86e-16

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 78.74  E-value: 6.86e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636746  108 LIVLDLSRNTIS-EIPRGigLLTRLQELILSYNKIK-TVPKELSNCTSLEKLELAVNRDISDLPPELSKLLKLTHLDLSM 185
Cdd:PLN00113 120 LRYLNLSNNNFTgSIPRG--SIPNLETLDLSNNMLSgEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLAS 197

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636746  186 NQFT-TIPHAVLDMPALEWLDMGSNSLQ-QLPDSLDRMRSLHTLWLQRNEIT-CLPETIKNMKNLGTLVLSNNKLQD-IP 261
Cdd:PLN00113 198 NQLVgQIPRELGQMKSLKWIYLGYNNLSgEIPYEIGGLTSLNHLDLVYNNLTgPIPSSLGNLKNLQYLFLYQNKLSGpIP 277

                        170       180
                 ....*....|....*....|...
gi 33636746  262 GCMEEMTNLRFVNFRDNPLRLEV 284
Cdd:PLN00113 278 PSIFSLQKLISLDLSDNSLSGEI 300
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 66-224 1.48e-11

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 65.64  E-value: 1.48e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636746   66 RIEKEEWKtlpssllkLNQLQEWQLHRTGLL-KIPEFIGRfQHLIVLDLSRNTISE-IPRGIGLLTRLQELILSYNKIK- 142
Cdd:PLN00113 443 RINSRKWD--------MPSLQMLSLARNKFFgGLPDSFGS-KRLENLDLSRNQFSGaVPRKLGSLSELMQLKLSENKLSg 513

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636746  143 TVPKELSNCTsleklelavnrdisdlppelskllKLTHLDLSMNQFT-TIPHAVLDMPALEWLDMGSNSLQ-QLPDSLDR 220
Cdd:PLN00113 514 EIPDELSSCK------------------------KLVSLDLSHNQLSgQIPASFSEMPVLSQLDLSQNQLSgEIPKNLGN 569


                 ....
gi 33636746  221 MRSL 224
Cdd:PLN00113 570 VESL 573
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
3-247 8.73e-11

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 63.18  E-value: 8.73e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636746    3 ESAVCTGAVSAVKE--VWEERIKKH--HEDVKREKEFQ-------HKLVRIWEDRVSLTKLKEKVTREDGRVILriEKEE 71
Cdd:PRK15370 133 QASSASGSKDAVNYelIWSEWVKEApaKEAANREEAVQrmrdclkNNKTELRLKILGLTTIPACIPEQITTLIL--DNNE 210

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636746   72 WKTLPSSLLklNQLQEWQLHRTGLLKIPEFIGrfQHLIVLDLSRNTISEIPRGigLLTRLQELILSYNKIKTVPKEL--- 148
Cdd:PRK15370 211 LKSLPENLQ--GNIKTLYANSNQLTSIPATLP--DTIQEMELSINRITELPER--LPSALQSLDLFHNKISCLPENLpee 284

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636746  149 --------SNCTSLEK------LELAV-NRDISDLPPELSKLLK-------------------LTHLDLSMNQFTTIP-- 192
Cdd:PRK15370 285 lrylsvydNSIRTLPAhlpsgiTHLNVqSNSLTALPETLPPGLKtleagenaltslpaslppeLQVLDVSKNQITVLPet 364

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 33636746  193 ------------HAVLDMP-----ALEWLDMGSNSLQQLPDSLDRMRS----LHTLWLQRNEITclPETIKNMKNL 247
Cdd:PRK15370 365 lpptittldvsrNALTNLPenlpaALQIMQASRNNLVRLPESLPHFRGegpqPTRIIVEYNPFS--ERTIQNMQRL 438
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 90-280 2.75e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 59.41  E-value: 2.75e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636746  90 LHRTGLLKIPEFIgRFQHLIVLDLSRNTISEIPrGIGLLTRLQELILSYNKIKTVPkELSNCTSLEKLELAVNRdISDLp 169
Cdd:cd21340   9 LNDKNITKIDNLS-LCKNLKVLYLYDNKITKIE-NLEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGGNR-ISVV- 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636746 170 pE-LSKLLKLTHLDLSmNQfttiphavlDMPALEWLDMGSNSLQQLpdsldrMRSLHTLWLQRNEITCLpETIKNMKNLG 248
Cdd:cd21340  84 -EgLENLTNLEELHIE-NQ---------RLPPGEKLTFDPRSLAAL------SNSLRVLNISGNNIDSL-EPLAPLRNLE 145

                       170       180       190
                ....*....|....*....|....*....|....*
gi 33636746 249 TLVLSNNKLQDIP---GCMEEMTNLRFVNFRDNPL 280
Cdd:cd21340 146 QLDASNNQISDLEellDLLSSWPSLRELDLTGNPV 180
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 100-250 4.93e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 55.56  E-value: 4.93e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636746 100 EFIGRFQHLIVLDLSRNTISEIPrGIGLLTRLQELILSYNKIKTVpKELSNCTSLEKLELAVNRdisdLPPE-------- 171
Cdd:cd21340  40 ENLEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGGNRISVV-EGLENLTNLEELHIENQR----LPPGekltfdpr 113

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636746 172 -LSKLLK-LTHLDLSMNQFTTI-PHAVLDmpALEWLDMGSN---SLQQLPDSLDRMRSLHTLWLQRNEITCLP----ETI 241
Cdd:cd21340 114 sLAALSNsLRVLNISGNNIDSLePLAPLR--NLEQLDASNNqisDLEELLDLLSSWPSLRELDLTGNPVCKKPkyrdKII 191


                ....*....
gi 33636746 242 KNMKNLGTL 250
Cdd:cd21340 192 LASKSLEVL 200
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 72-257 1.30e-08

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 55.44  E-value: 1.30e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636746  72 WKTLPSSLLKLNQLQEWQLHRTGLLkiPEFIGRFQHLI------VLDLSRNTISeiPRGIGLLT--------RLQELILS 137
Cdd:cd00116  70 LQSLLQGLTKGCGLQELDLSDNALG--PDGCGVLESLLrssslqELKLNNNGLG--DRGLRLLAkglkdlppALEKLVLG 145

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636746 138 YNKI-----KTVPKELSNCTSLEKLELAVNrDISD-----LPPELSKLLKLTHLDLSMNQFT-----TIPHAVLDMPALE 202
Cdd:cd00116 146 RNRLegascEALAKALRANRDLKELNLANN-GIGDagiraLAEGLKANCNLEVLDLNNNGLTdegasALAETLASLKSLE 224

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 33636746 203 WLDMGSNSLQQ------LPDSLDRMRSLHTLWLQRNEITC-----LPETIKNMKNLGTLVLSNNKL 257
Cdd:cd00116 225 VLNLGDNNLTDagaaalASALLSPNISLLTLSLSCNDITDdgakdLAEVLAEKESLLELDLRGNKF 290
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
133-289 1.61e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 52.78  E-value: 1.61e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636746  133 ELILSYNKIKTVPKELSNCTSLEKLElavNRDISDLPPELSKLLKltHLDLSMNQFTTIPHAVLDmpALEWLDMGSNSLQ 212
Cdd:PRK15370 182 ELRLKILGLTTIPACIPEQITTLILD---NNELKSLPENLQGNIK--TLYANSNQLTSIPATLPD--TIQEMELSINRIT 254

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 33636746  213 QLPDSLDRmrSLHTLWLQRNEITCLPETIKNmkNLGTLVLSNNKLQDIPGCMEemTNLRFVNFRDNPLR-LEVTLPPS 289
Cdd:PRK15370 255 ELPERLPS--ALQSLDLFHNKISCLPENLPE--ELRYLSVYDNSIRTLPAHLP--SGITHLNVQSNSLTaLPETLPPG 326
PLN03150 PLN03150
hypothetical protein; Provisional
 98-176 2.05e-07

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 52.51  E-value: 2.05e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636746   98 IPEFIGRFQHLIVLDLSRNTI-SEIPRGIGLLTRLQELILSYNKIK-TVPKELSNCTSLEKLELAVNRDISDLPPELSKL 175
Cdd:PLN03150 434 IPNDISKLRHLQSINLSGNSIrGNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSLSGRVPAALGGR 513


                 .
gi 33636746  176 L 176
Cdd:PLN03150 514 L 514
LRR_8 pfam13855
Leucine rich repeat;
152-211 1.86e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.74  E-value: 1.86e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 33636746   152 TSLEKLELAVNRdISDLPPE-LSKLLKLTHLDLSMNQFTTI-PHAVLDMPALEWLDMGSNSL 211
Cdd:pfam13855   1 PNLRSLDLSNNR-LTSLDDGaFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
222-280 2.14e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.74  E-value: 2.14e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 33636746   222 RSLHTLWLQRNEITCL-PETIKNMKNLGTLVLSNNKLQDI-PGCMEEMTNLRFVNFRDNPL 280
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 77-192 6.42e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 43.62  E-value: 6.42e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636746  77 SSLLKLNQLQewqLHRTGLLKIpEFIGRFQHLIVLDLSRNTISEI----------------------------PRGI-GL 127
Cdd:cd21340  43 EFLTNLTHLY---LQNNQIEKI-ENLENLVNLKKLYLGGNRISVVeglenltnleelhienqrlppgekltfdPRSLaAL 118

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 33636746 128 LTRLQELILSYNKIKTVpKELSNCTSLEKLELAVNR--DISDLPPELSKLLKLTHLDLSMNQFTTIP 192
Cdd:cd21340 119 SNSLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQisDLEELLDLLSSWPSLRELDLTGNPVCKKP 184
LRR_8 pfam13855
Leucine rich repeat;
177-234 6.68e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.20  E-value: 6.68e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636746   177 KLTHLDLSMNQFTTI-PHAVLDMPALEWLDMGSNSLQQL-PDSLDRMRSLHTLWLQRNEI 234
Cdd:pfam13855   2 NLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
84-141 7.30e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.20  E-value: 7.30e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636746    84 QLQEWQLHRTGLLKI-PEFIGRFQHLIVLDLSRNTISEI-PRGIGLLTRLQELILSYNKI 141
Cdd:pfam13855   2 NLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 100-283 7.41e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.88  E-value: 7.41e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636746 100 EFIGRFQHLIVLDLSRNTISEIpRGIGLLTRLQ------ELILSYNK-------IKTVPKELSNCTSLEKLELAVNRDIS 166
Cdd:cd00116  17 ELLPKLLCLQVLRLEGNTLGEE-AAKALASALRpqpslkELCLSLNEtgriprgLQSLLQGLTKGCGLQELDLSDNALGP 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636746 167 DLPPELSKLLK---LTHLDLSMNQF-----TTIPHAVLD-MPALEWLDMGSNSL-----QQLPDSLDRMRSLHTLWLQRN 232
Cdd:cd00116  96 DGCGVLESLLRsssLQELKLNNNGLgdrglRLLAKGLKDlPPALEKLVLGRNRLegascEALAKALRANRDLKELNLANN 175

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 33636746 233 E-----ITCLPETIKNMKNLGTLVLSNNKL-----QDIPGCMEEMTNLRFVNFRDNPLRLE 283
Cdd:cd00116 176 GigdagIRALAEGLKANCNLEVLDLNNNGLtdegaSALAETLASLKSLEVLNLGDNNLTDA 236
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 36-277 1.08e-04

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 44.10  E-value: 1.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636746    36 QHKLVRIWEDRVSLTKLKE------KVTREDGRVILRIEKEEWK--------TLPSSLLKLNQLQEWQLHR--------- 92
Cdd:PLN03210  620 GSKLEKLWDGVHSLTGLRNidlrgsKNLKEIPDLSMATNLETLKlsdcsslvELPSSIQYLNKLEDLDMSRcenleilpt 699

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636746    93 ------------TGLLKIPEFIGRFQHLIVLDLSRNTISEIPRGIGLlTRLQELILSYNKIKTVPKELSNCT-------- 152
Cdd:PLN03210  700 ginlkslyrlnlSGCSRLKSFPDISTNISWLDLDETAIEEFPSNLRL-ENLDELILCEMKSEKLWERVQPLTplmtmlsp 778

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636746   153 SLEKLELAVNRDISDLPPELSKLLKLTHLDLsMN--QFTTIPHAVlDMPALEWLDM-GSNSLQQLPDSldrMRSLHTLWL 229
Cdd:PLN03210  779 SLTRLFLSDIPSLVELPSSIQNLHKLEHLEI-ENciNLETLPTGI-NLESLESLDLsGCSRLRTFPDI---STNISDLNL 853

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 33636746   230 QRNEITCLPETIKNMKNLGTLVLSN-NKLQDIPGCMEEMTNLRFVNFRD 277
Cdd:PLN03210  854 SRTGIEEVPWWIEKFSNLSFLDMNGcNNLQRVSLNISKLKHLETVDFSD 902
LRR_8 pfam13855
Leucine rich repeat;
106-163 1.54e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.04  E-value: 1.54e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636746   106 QHLIVLDLSRNTISEIPRGIGL-LTRLQELILSYNKIKTV-PKELSNCTSLEKLELAVNR 163
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNR 60
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 70-259 1.54e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.11  E-value: 1.54e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636746  70 EEWKTLPSSLLKLNQLQEWQ--LHRTGLLKIPEFIGRFQHLIVLDLSRNTISEIPRGIGLL-------TRLQELILSYNK 140
Cdd:cd00116  13 ERATELLPKLLCLQVLRLEGntLGEEAAKALASALRPQPSLKELCLSLNETGRIPRGLQSLlqgltkgCGLQELDLSDNA 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636746 141 IK----TVPKELSNCTSLEKLELAVN-----------RDISDLPPELSKLLkLTHLDLSMNQFTTIPHAVLDMPALEWLD 205
Cdd:cd00116  93 LGpdgcGVLESLLRSSSLQELKLNNNglgdrglrllaKGLKDLPPALEKLV-LGRNRLEGASCEALAKALRANRDLKELN 171

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 33636746 206 MGSNSLQQ-----LPDSLDRMRSLHTLWLQRNEITC-----LPETIKNMKNLGTLVLSNNKLQD 259
Cdd:cd00116 172 LANNGIGDagiraLAEGLKANCNLEVLDLNNNGLTDegasaLAETLASLKSLEVLNLGDNNLTD 235
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 129-170 3.27e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 37.61  E-value: 3.27e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 33636746   129 TRLQELILSYNKIKTVPkELSNCTSLEKLELAVNRDISDLPP 170
Cdd:pfam12799   1 PNLEVLDLSNNQITDIP-PLAKLPNLETLDLSGNNKITDLSD 41
PLN03150 PLN03150
hypothetical protein; Provisional
 121-195 4.13e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 42.11  E-value: 4.13e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 33636746  121 IPRGIGLLTRLQELILSYNKIK-TVPKELSNCTSLEKLELAVNRDISDLPPELSKLLKLTHLDLSMNQFT-TIPHAV 195
Cdd:PLN03150 434 IPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSgRVPAAL 510
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
75-259 4.26e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 42.07  E-value: 4.26e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636746   75 LPSSLLKL----NQL----------QEWQLHRTGLLKIPEFIGRFQHLIVLDLSRNTISEIPRGiglltrLQELILSYNK 140
Cdd:PRK15387 280 LPSGLCKLwifgNQLtslpvlppglQELSVSDNQLASLPALPSELCKLWAYNNQLTSLPTLPSG------LQELSVSDNQ 353

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636746  141 IKTVPKELSNCTSLekleLAVNRDISDLPPELSKLLKLThldLSMNQFTTIPHavldMPA-LEWLDMGSNSLQQLPDSLD 219
Cdd:PRK15387 354 LASLPTLPSELYKL----WAYNNRLTSLPALPSGLKELI---VSGNRLTSLPV----LPSeLKELMVSGNRLTSLPMLPS 422

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 33636746  220 RMRSLHtlwLQRNEITCLPETIKNMKNLGTLVLSNNKLQD 259
Cdd:PRK15387 423 GLLSLS---VYRNQLTRLPESLIHLSSETTVNLEGNPLSE 459
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 175-271 5.43e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.54  E-value: 5.43e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636746 175 LLKLTHLDLSMNQFTTIPhaVLDM-PALEWLDMGSNSLQQLPDsLDRMRSLHTLWLQRNEITCLpETIKNMKNLGTLVLS 253
Cdd:cd21340   1 LKRITHLYLNDKNITKID--NLSLcKNLKVLYLYDNKITKIEN-LEFLTNLTHLYLQNNQIEKI-ENLENLVNLKKLYLG 76

                        90
                ....*....|....*...
gi 33636746 254 NNKLQDIPGcMEEMTNLR 271
Cdd:cd21340  77 GNRISVVEG-LENLTNLE 93
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
75-280 6.25e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 41.69  E-value: 6.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636746   75 LPSSLLKL----NQLQEWQLHRTGLLKIPEFIGRFQHLIVLD-------LSRNTISEIPRgigLLTRLQELILSYNKIKT 143
Cdd:PRK15387 240 LPPELRTLevsgNQLTSLPVLPPGLLELSIFSNPLTHLPALPsglcklwIFGNQLTSLPV---LPPGLQELSVSDNQLAS 316

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636746  144 VPKELSNCTSLekleLAVNRDISDLPPELSKLLKLTHLDLSMNQFTTIPHAVLDMPA----LEWLDMGSNSLQQLPDSLD 219
Cdd:PRK15387 317 LPALPSELCKL----WAYNNQLTSLPTLPSGLQELSVSDNQLASLPTLPSELYKLWAynnrLTSLPALPSGLKELIVSGN 392

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636746  220 RMRSL-------HTLWLQRNEITCLPetiknMKNLGTLVLS--NNKLQDIPGCMEEMTNLRFVNFRDNPL 280
Cdd:PRK15387 393 RLTSLpvlpselKELMVSGNRLTSLP-----MLPSGLLSLSvyRNQLTRLPESLIHLSSETTVNLEGNPL 457
PLN03150 PLN03150
hypothetical protein; Provisional
 168-235 9.18e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 40.95  E-value: 9.18e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636746  168 LPPELSKLLKLTHLDLSMNQFT-TIPHAVLDMPALEWLDMGSNSLQ-QLPDSLDRMRSLHTLWLQRNEIT 235
Cdd:PLN03150 434 IPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSLS 503
PLN03150 PLN03150
hypothetical protein; Provisional
 213-284 1.23e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 40.57  E-value: 1.23e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 33636746  213 QLPDSLDRMRSLHTLWLQRNEIT-CLPETIKNMKNLGTLVLSNNKLQ-DIPGCMEEMTNLRFVNFRDNPLRLEV 284
Cdd:PLN03150 433 FIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSLSGRV 506
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 126-259 1.61e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 40.16  E-value: 1.61e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636746 126 GLLTRLQELILSYNKI-----KTVPKELSNCTSLEKLELAVNrDISDLPPE-----LSKLLKLTHLDLSMNQfttiphav 195
Cdd:COG5238 177 LQNNSVETVYLGCNQIgdegiEELAEALTQNTTVTTLWLKRN-PIGDEGAEilaeaLKGNKSLTTLDLSNNQ-------- 247

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 33636746 196 ldmpalewldMGSNSLQQLPDSLDRMRSLHTLWLQRNEITC-----LPETIKNMKNLGTLVLSNNKLQD 259
Cdd:COG5238 248 ----------IGDEGVIALAEALKNNTTVETLYLSGNQIGAegaiaLAKALQGNTTLTSLDLSVNRIGD 306
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 201-271 5.90e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 38.23  E-value: 5.90e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33636746 201 LEWLDMGSNSLQQ-----LPDSLDRMRSLHTLWLQRNEIT-----CLPETIKNMKNLGTLVLSNNKLQDiPGCMEEMTNL 270
Cdd:COG5238 182 VETVYLGCNQIGDegieeLAEALTQNTTVTTLWLKRNPIGdegaeILAEALKGNKSLTTLDLSNNQIGD-EGVIALAEAL 260


                .
gi 33636746 271 R 271
Cdd:COG5238 261 K 261
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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